                         SEQUENCE LISTING

<110>  NAVICURE BIOPHARMACEUTICALS LIMITED
 
<120>  FUSION PROTEINS FOR IMMUNOTHERAPY AGAINST CANCER AND INFECTIOUS 
       DISEASES

<130>  10040-001PCT

<150>  63/020,545
<151>  2020-05-06

<160>  56    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable linker 1


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Arg Xaa Xaa Arg 
1               


<210>  2
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cleavable linker 2


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is K, F or R.

<400>  2

Arg Xaa Arg Xaa Xaa Arg 
1               5       


<210>  3
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid linker 1

<400>  3

Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala 
1               5                   10                  15      


Ala Lys 
        


<210>  4
<211>  613
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  4

Ala Glu Glu Ala Phe Asp Leu Trp Asn Glu Cys Ala Lys Ala Cys Val 
1               5                   10                  15      


Leu Asp Leu Lys Asp Gly Val Arg Ser Ser Arg Met Ser Val Asp Pro 
            20                  25                  30          


Ala Ile Ala Asp Thr Asn Gly Gln Gly Val Leu His Tyr Ser Met Val 
        35                  40                  45              


Leu Glu Gly Gly Asn Asp Ala Leu Lys Leu Ala Ile Asp Asn Ala Leu 
    50                  55                  60                  


Ser Ile Thr Ser Asp Gly Leu Thr Ile Arg Leu Glu Gly Gly Val Glu 
65                  70                  75                  80  


Pro Asn Lys Pro Val Arg Tyr Ser Tyr Thr Arg Gln Ala Arg Gly Ser 
                85                  90                  95      


Trp Ser Leu Asn Trp Leu Val Pro Ile Gly His Glu Lys Pro Ser Asn 
            100                 105                 110         


Ile Lys Val Phe Ile His Glu Leu Asn Ala Gly Asn Gln Leu Ser His 
        115                 120                 125             


Met Ser Pro Ile Tyr Thr Ile Glu Met Gly Asp Glu Leu Leu Ala Lys 
    130                 135                 140                 


Leu Ala Arg Asp Ala Thr Phe Phe Val Arg Ala His Glu Ser Asn Glu 
145                 150                 155                 160 


Met Gln Pro Thr Leu Ala Ile Ser His Ala Gly Val Ser Val Val Met 
                165                 170                 175     


Ala Gln Thr Gln Pro Arg Arg Glu Lys Arg Trp Ser Glu Trp Ala Ser 
            180                 185                 190         


Gly Lys Val Leu Cys Leu Leu Asp Pro Leu Asp Gly Val Tyr Asn Tyr 
        195                 200                 205             


Leu Ala Gln Gln Arg Cys Asn Leu Asp Asp Thr Trp Glu Gly Lys Ile 
    210                 215                 220                 


Tyr Arg Val Leu Ala Gly Asn Pro Ala Lys His Asp Leu Asp Ile Lys 
225                 230                 235                 240 


Pro Thr Val Ile Ser His Arg Leu His Phe Pro Glu Gly Gly Ser Leu 
                245                 250                 255     


Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro Leu Glu Thr Phe 
            260                 265                 270         


Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly 
        275                 280                 285             


Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser 
    290                 295                 300                 


Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu Ala Ser Pro Gly 
305                 310                 315                 320 


Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln Pro Glu Gln Ala 
                325                 330                 335     


Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu Arg Phe Val Arg 
            340                 345                 350         


Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn Ala Asp Val Val 
        355                 360                 365             


Ser Leu Thr Cys Pro Val Ala Ala Gly Glu Cys Ala Gly Pro Ala Asp 
    370                 375                 380                 


Ser Gly Asp Ala Leu Leu Glu Arg Asn Tyr Pro Thr Gly Ala Glu Phe 
385                 390                 395                 400 


Leu Gly Asp Gly Gly Asp Val Ser Phe Ser Thr Arg Gly Thr Gln Asn 
                405                 410                 415     


Trp Thr Val Glu Arg Leu Leu Gln Ala His Arg Gln Leu Glu Glu Arg 
            420                 425                 430         


Gly Tyr Val Phe Val Gly Tyr His Gly Thr Phe Leu Glu Ala Ala Gln 
        435                 440                 445             


Ser Ile Val Phe Gly Gly Val Arg Ala Arg Ser Gln Asp Leu Asp Ala 
    450                 455                 460                 


Ile Trp Arg Gly Phe Tyr Ile Ala Gly Asp Pro Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Tyr Ala Gln Asp Gln Glu Pro Asp Ala Arg Gly Arg Ile Arg Asn Gly 
                485                 490                 495     


Ala Leu Leu Arg Val Tyr Val Pro Arg Ser Ser Leu Pro Gly Phe Tyr 
            500                 505                 510         


Arg Thr Gly Leu Thr Leu Ala Ala Pro Glu Ala Ala Gly Glu Val Glu 
        515                 520                 525             


Arg Leu Ile Gly His Pro Leu Pro Leu Arg Leu Asp Ala Ile Thr Gly 
    530                 535                 540                 


Pro Glu Glu Glu Gly Gly Arg Leu Glu Thr Ile Leu Gly Trp Pro Leu 
545                 550                 555                 560 


Ala Glu Arg Thr Val Val Ile Pro Ser Ala Ile Pro Thr Asp Pro Arg 
                565                 570                 575     


Asn Val Gly Gly Asp Leu Ala Pro Ser Ser Ile Pro Asp Gln Glu Gln 
            580                 585                 590         


Ala Ile Ser Ala Leu Pro Asp Tyr Ala Ser Gln Pro Gly Lys Pro Ser 
        595                 600                 605             


Arg Glu Asp Leu Lys 
    610             


<210>  5
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE translocation peptide (PE280-305, minimal)

<400>  5

Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
1               5                   10                  15      


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp 
            20                  25      


<210>  6
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE translocation peptide (PE280-313)

<400>  6

Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val 
1               5                   10                  15      


Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val 
            20                  25                  30          


Ile Arg 
        


<210>  7
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE translocation peptide (PE268-313)

<400>  7

Pro Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln 
1               5                   10                  15      


Leu Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu 
            20                  25                  30          


Ala Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
        35                  40                  45      


<210>  8
<211>  61
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE translocation peptide (PE253-313)

<400>  8

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg 
    50                  55                  60      


<210>  9
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PE translocation peptide (PE253-364)

<400>  9

Gly Gly Ser Leu Ala Ala Leu Thr Ala His Gln Ala Cys His Leu Pro 
1               5                   10                  15      


Leu Glu Thr Phe Thr Arg His Arg Gln Pro Arg Gly Trp Glu Gln Leu 
            20                  25                  30          


Glu Gln Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala 
        35                  40                  45              


Ala Arg Leu Ser Trp Asn Gln Val Asp Gln Val Ile Arg Asn Ala Leu 
    50                  55                  60                  


Ala Ser Pro Gly Ser Gly Gly Asp Leu Gly Glu Ala Ile Arg Glu Gln 
65                  70                  75                  80  


Pro Glu Gln Ala Arg Leu Ala Leu Thr Leu Ala Ala Ala Glu Ser Glu 
                85                  90                  95      


Arg Phe Val Arg Gln Gly Thr Gly Asn Asp Glu Ala Gly Ala Ala Asn 
            100                 105                 110         


<210>  10
<211>  293
<212>  PRT
<213>  Shigella dysenteriae

<400>  10

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Thr Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  11
<211>  293
<212>  PRT
<213>  Escherichia coli

<400>  11

Lys Glu Phe Thr Leu Asp Phe Ser Thr Ala Lys Thr Tyr Val Asp Ser 
1               5                   10                  15      


Leu Asn Val Ile Arg Ser Ala Ile Gly Thr Pro Leu Gln Thr Ile Ser 
            20                  25                  30          


Ser Gly Gly Thr Ser Leu Leu Met Ile Asp Ser Gly Ser Gly Asp Asn 
        35                  40                  45              


Leu Phe Ala Val Asp Val Arg Gly Ile Asp Pro Glu Glu Gly Arg Phe 
    50                  55                  60                  


Asn Asn Leu Arg Leu Ile Val Glu Arg Asn Asn Leu Tyr Val Thr Gly 
65                  70                  75                  80  


Phe Val Asn Arg Thr Asn Asn Val Phe Tyr Arg Phe Ala Asp Phe Ser 
                85                  90                  95      


His Val Thr Phe Pro Gly Thr Thr Ala Val Thr Leu Ser Gly Asp Ser 
            100                 105                 110         


Ser Tyr Thr Thr Leu Gln Arg Val Ala Gly Ile Ser Arg Thr Gly Met 
        115                 120                 125             


Gln Ile Asn Arg His Ser Leu Thr Thr Ser Tyr Leu Asp Leu Met Ser 
    130                 135                 140                 


His Ser Gly Thr Ser Leu Thr Gln Ser Val Ala Arg Ala Met Leu Arg 
145                 150                 155                 160 


Phe Val Thr Val Thr Ala Glu Ala Leu Arg Phe Arg Gln Ile Gln Arg 
                165                 170                 175     


Gly Phe Arg Thr Thr Leu Asp Asp Leu Ser Gly Arg Ser Tyr Val Met 
            180                 185                 190         


Thr Ala Glu Asp Val Asp Leu Thr Leu Asn Trp Gly Arg Leu Ser Ser 
        195                 200                 205             


Val Leu Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
    210                 215                 220                 


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
225                 230                 235                 240 


Asn Cys His His His Ala Ser Arg Val Ala Arg Met Ala Ser Asp Glu 
                245                 250                 255     


Phe Pro Ser Met Cys Pro Ala Asp Gly Arg Val Arg Gly Ile Thr His 
            260                 265                 270         


Asn Lys Ile Leu Trp Asp Ser Ser Thr Leu Gly Ala Ile Leu Met Arg 
        275                 280                 285             


Arg Thr Ile Ser Ser 
    290             


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stx translocation peptide (Stx240-247, minimal)

<400>  12

Leu Asn Cys His His His Ala Ser 
1               5               


<210>  13
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stx translocation peptide (Stx240-251)

<400>  13

Leu Asn Cys His His His Ala Ser Arg Val Ala Arg 
1               5                   10          


<210>  14
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stx translocation peptide (Stx211-247)

<400>  14

Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
1               5                   10                  15      


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            20                  25                  30          


His His His Ala Ser 
        35          


<210>  15
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stx translocation peptide (Stx211-251)

<400>  15

Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe 
1               5                   10                  15      


Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys 
            20                  25                  30          


His His His Ala Ser Arg Val Ala Arg 
        35                  40      


<210>  16
<211>  84
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stx translocation peptide (Stx168-251)

<400>  16

Ala Leu Arg Phe Arg Gln Ile Gln Arg Gly Phe Arg Thr Thr Leu Asp 
1               5                   10                  15      


Asp Leu Ser Gly Arg Ser Tyr Val Met Thr Ala Glu Asp Val Asp Leu 
            20                  25                  30          


Thr Leu Asn Trp Gly Arg Leu Ser Ser Val Leu Pro Asp Tyr His Gly 
        35                  40                  45              


Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly Ser Ile Asn Ala 
    50                  55                  60                  


Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His His His Ala Ser 
65                  70                  75                  80  


Arg Val Ala Arg 
                


<210>  17
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     


<210>  18
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated CD40 ligand (CD40L47-261)

<400>  18

His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
1               5                   10                  15      


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            20                  25                  30          


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        35                  40                  45              


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    50                  55                  60                  


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
65                  70                  75                  80  


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                85                  90                  95      


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            100                 105                 110         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        115                 120                 125             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    130                 135                 140                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
145                 150                 155                 160 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                165                 170                 175     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            180                 185                 190         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        195                 200                 205             


Ser Phe Gly Leu Leu Lys Leu 
    210                 215 


<210>  19
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Truncated CD40 ligand (CD40L108-261, also referred to as 
       18sCD40L)

<400>  19

Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
1               5                   10                  15      


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
            20                  25                  30          


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
        35                  40                  45              


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
    50                  55                  60                  


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
65                  70                  75                  80  


Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg 
                85                  90                  95      


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
            100                 105                 110         


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
        115                 120                 125             


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
    130                 135                 140                 


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
145                 150                 


<210>  20
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD40 scFv (VH-L-VL)

<400>  20

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Val Trp Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Ser Gly Gly Ser Ser Tyr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala 
    130                 135                 140                 


Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Thr Gly Ser Ser 
145                 150                 155                 160 


Ser Asn Ile Gly Ala Gly Tyr Asn Val Tyr Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Ala Ala Trp Asp Lys Ser Ile Ser Gly Leu Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly 
                245     


<210>  21
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-CD40 scFv (VL-L-VH)

<400>  21

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Lys Ser 
                85                  90                  95      


Ile Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly 
145                 150                 155                 160 


Met His Val Trp Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu Ser 
                165                 170                 175     


Tyr Ile Ser Gly Gly Ser Ser Tyr Ile Phe Tyr Ala Asp Ser Val Arg 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Ala Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  22
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the anti-CD40 scFv

<400>  22

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Val Trp Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Ser Tyr Ile Ser Gly Gly Ser Ser Tyr Ile Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Ala Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  23
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the anti-CD40 scFv

<400>  23

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asn Val Tyr Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu 
65                  70                  75                  80  


Arg Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Lys Ser 
                85                  90                  95      


Ile Ser Gly Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1

<400>  24

Gly Phe Thr Phe Ser Thr Tyr Gly Met His 
1               5                   10  


<210>  25
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2

<400>  25

Gly Lys Gly Leu Glu Trp Leu Ser Tyr Ile Ser Gly Gly Ser Ser Tyr 
1               5                   10                  15      


Ile Phe Tyr Ala Asp Ser Val Arg Gly Arg 
            20                  25      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3

<400>  26

Cys Ala Arg Ile Leu Arg Gly Gly Ser Gly Met Asp Leu 
1               5                   10              


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1

<400>  27

Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly Tyr Asn Val Tyr 
1               5                   10                  15  


<210>  28
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2

<400>  28

Gly Asn Ile Asn Arg Pro Ser 
1               5           


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3

<400>  29

Cys Ala Ala Trp Asp Lys Ser Ile Ser Gly Leu Val 
1               5                   10          


<210>  30
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  30

Lys Asp Glu Leu 
1               


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  31

Lys Lys Asp Leu Arg Asp Glu Leu Lys Asp Glu Leu 
1               5                   10          


<210>  32
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  32

Lys Lys Asp Glu Leu Arg Asp Glu Leu Lys Asp Glu Leu 
1               5                   10              


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  33

Lys Lys Asp Glu Leu Arg Val Glu Leu Lys Asp Glu Leu 
1               5                   10              


<210>  34
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ER retention sequence

<400>  34

Lys Asp Glu Leu Lys Asp Glu Leu Lys Asp Glu Leu 
1               5                   10          


<210>  35
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is I or L

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is V, F or A

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is M or L

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa is L or I

<400>  35

Thr Asp Ile Tyr Phe Cys Lys Xaa Glu Xaa Xaa Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Xaa Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
            20                  25              


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-activating peptide (minimal)

<400>  36

Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val Met Tyr Pro Pro Pro Tyr 
1               5                   10                  15      


Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile Ile His 
            20                  25              


<210>  37
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28-activating peptide

<400>  37

Asn Cys Asp Gly Lys Leu Gly Asn Glu Ser Val Thr Phe Tyr Leu Gln 
1               5                   10                  15      


Asn Leu Tyr Val Asn Gln Thr Asp Ile Tyr Phe Cys Lys Ile Glu Val 
            20                  25                  30          


Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn Gly Thr Ile 
        35                  40                  45              


Ile His Val Lys Gly 
    50              


<210>  38
<211>  98
<212>  PRT
<213>  Human papillomavirus type 16

<400>  38

Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210>  39
<211>  104
<212>  PRT
<213>  Human papillomavirus type 18

<400>  39

His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu Pro 
1               5                   10                  15      


Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser Asp 
            20                  25                  30          


Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His Leu 
        35                  40                  45              


Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met Cys 
    50                  55                  60                  


Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala Asp 
65                  70                  75                  80  


Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe Val 
                85                  90                  95      


Cys Pro Trp Cys Ala Ser Gln Gln 
            100                 


<210>  40
<211>  154
<212>  PRT
<213>  Hepatitis B virus

<400>  40

Met Ala Ala Arg Met Cys Cys Gln Leu Asp Pro Ala Arg Asp Val Leu 
1               5                   10                  15      


Cys Leu Arg Pro Val Gly Ala Glu Ser Arg Gly Arg Pro Leu Pro Gly 
            20                  25                  30          


Pro Leu Gly Ala Leu Pro Pro Ser Ser Ala Ser Ala Val Pro Ala Asp 
        35                  40                  45              


His Gly Ser His Leu Ser Leu Arg Gly Leu Pro Val Cys Ser Phe Ser 
    50                  55                  60                  


Ser Ala Gly Pro Cys Ala Leu Arg Phe Thr Ser Ala Arg Arg Met Glu 
65                  70                  75                  80  


Thr Thr Val Asn Ala Pro Trp Ser Leu Pro Thr Val Leu His Lys Arg 
                85                  90                  95      


Thr Ile Gly Leu Ser Gly Arg Ser Met Thr Trp Ile Glu Glu Tyr Ile 
            100                 105                 110         


Lys Asp Cys Val Phe Lys Asp Trp Glu Glu Leu Gly Glu Glu Ile Arg 
        115                 120                 125             


Leu Lys Val Phe Val Leu Gly Gly Cys Arg His Lys Leu Val Cys Ser 
    130                 135                 140                 


Pro Ala Pro Cys Asn Phe Phe Thr Ser Ala 
145                 150                 


<210>  41
<211>  108
<212>  PRT
<213>  Hepatitis B virus

<400>  41

Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn Leu 
1               5                   10                  15      


Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp Pro 
            20                  25                  30          


Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro Asn 
        35                  40                  45              


Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe Gly 
    50                  55                  60                  


Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro Gln 
65                  70                  75                  80  


Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala Ser 
                85                  90                  95      


Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile 
            100                 105             


<210>  42
<211>  190
<212>  PRT
<213>  Hepatitis C virus

<400>  42

Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 
1               5                   10                  15      


Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 
            20                  25                  30          


Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 
        35                  40                  45              


Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 
    50                  55                  60                  


Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 
65                  70                  75                  80  


Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Met Gly Trp Ala Gly Trp 
                85                  90                  95      


Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Thr Asp Pro 
            100                 105                 110         


Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 
        115                 120                 125             


Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 
    130                 135                 140                 


Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 
145                 150                 155                 160 


Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 
                165                 170                 175     


Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser 
            180                 185                 190 


<210>  43
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigen SARS-CoV-2 spike protein

<400>  43

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  44
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Asn Gly Asp Asp Ala Phe Ala Arg Arg Pro Thr Val Gly Ala Gln 
1               5                   10                  15      


Ile Pro Glu Lys Ile Gln Lys Ala Phe Asp Asp Ile Ala Lys Tyr Phe 
            20                  25                  30          


Ser Lys Glu Glu Trp Glu Lys Met Lys Ala Ser Glu Lys Ile Phe Tyr 
        35                  40                  45              


Val Tyr Met Lys Arg Lys Tyr Glu Ala Met Thr Lys Leu Gly Phe Lys 
    50                  55                  60                  


Ala Thr Leu Pro Pro Phe Met Cys Asn Lys Arg Ala Glu Asp Phe Gln 
65                  70                  75                  80  


Gly Asn Asp Leu Asp Asn Asp Pro Asn Arg Gly Asn Gln Val Glu Arg 
                85                  90                  95      


Pro Gln Met Thr Phe Gly Arg Leu Gln Gly Ile Ser Pro Lys Ile Met 
            100                 105                 110         


Pro Lys Lys Pro Ala Glu Glu Gly Asn Asp Ser Glu Glu Val Pro Glu 
        115                 120                 125             


Ala Ser Gly Pro Gln Asn Asp Gly Lys Glu Leu Cys Pro Pro Gly Lys 
    130                 135                 140                 


Pro Thr Thr Ser Glu Lys Ile His Glu Arg Ser Gly Pro Lys Arg Gly 
145                 150                 155                 160 


Glu His Ala Trp Thr His Arg Leu Arg Glu Arg Lys Gln Leu Val Ile 
                165                 170                 175     


Tyr Glu Glu Ile Ser Asp Pro Glu Glu Asp Asp 
            180                 185         


<210>  45
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Pro Leu Glu Gln Arg Ser Gln His Cys Lys Pro Glu Glu Gly Leu 
1               5                   10                  15      


Glu Ala Arg Gly Glu Ala Leu Gly Leu Val Gly Ala Gln Ala Pro Ala 
            20                  25                  30          


Thr Glu Glu Gln Glu Ala Ala Ser Ser Ser Ser Thr Leu Val Glu Val 
        35                  40                  45              


Thr Leu Gly Glu Val Pro Ala Ala Glu Ser Pro Asp Pro Pro Gln Ser 
    50                  55                  60                  


Pro Gln Gly Ala Ser Ser Leu Pro Thr Thr Met Asn Tyr Pro Leu Trp 
65                  70                  75                  80  


Ser Gln Ser Tyr Glu Asp Ser Ser Asn Gln Glu Glu Glu Gly Pro Ser 
                85                  90                  95      


Thr Phe Pro Asp Leu Glu Ser Glu Phe Gln Ala Ala Leu Ser Arg Lys 
            100                 105                 110         


Val Ala Glu Leu Val His Phe Leu Leu Leu Lys Tyr Arg Ala Arg Glu 
        115                 120                 125             


Pro Val Thr Lys Ala Glu Met Leu Gly Ser Val Val Gly Asn Trp Gln 
    130                 135                 140                 


Tyr Phe Phe Pro Val Ile Phe Ser Lys Ala Ser Ser Ser Leu Gln Leu 
145                 150                 155                 160 


Val Phe Gly Ile Glu Leu Met Glu Val Asp Pro Ile Gly His Leu Tyr 
                165                 170                 175     


Ile Phe Ala Thr Cys Leu Gly Leu Ser Tyr Asp Gly Leu Leu Gly Asp 
            180                 185                 190         


Asn Gln Ile Met Pro Lys Ala Gly Leu Leu Ile Ile Val Leu Ala Ile 
        195                 200                 205             


Ile Ala Arg Glu Gly Asp Cys Ala Pro Glu Glu Lys Ile Trp Glu Glu 
    210                 215                 220                 


Leu Ser Val Leu Glu Val Phe Glu Gly Arg Glu Asp Ser Ile Leu Gly 
225                 230                 235                 240 


Asp Pro Lys Lys Leu Leu Thr Gln His Phe Val Gln Glu Asn Tyr Leu 
                245                 250                 255     


Glu Tyr Arg Gln Val Pro Gly Ser Asp Pro Ala Cys Tyr Glu Phe Leu 
            260                 265                 270         


Trp Gly Pro Arg Ala Leu Val Glu Thr Ser Tyr Val Lys Val Leu His 
        275                 280                 285             


His Met Val Lys Ile Ser Gly Gly Pro His Ile Ser Tyr Pro Pro Leu 
    290                 295                 300                 


His Glu Trp Val Leu Arg Glu Gly Glu Glu 
305                 310                 


<210>  46
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Gln Ala Glu Gly Arg Gly Thr Gly Gly Ser Thr Gly Asp Ala Asp 
1               5                   10                  15      


Gly Pro Gly Gly Pro Gly Ile Pro Asp Gly Pro Gly Gly Asn Ala Gly 
            20                  25                  30          


Gly Pro Gly Glu Ala Gly Ala Thr Gly Gly Arg Gly Pro Arg Gly Ala 
        35                  40                  45              


Gly Ala Ala Arg Ala Ser Gly Pro Gly Gly Gly Ala Pro Arg Gly Pro 
    50                  55                  60                  


His Gly Gly Ala Ala Ser Gly Leu Asn Gly Cys Cys Arg Cys Gly Ala 
65                  70                  75                  80  


Arg Gly Pro Glu Ser Arg Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe 
                85                  90                  95      


Ala Thr Pro Met Glu Ala Glu Leu Ala Arg Arg Ser Leu Ala Gln Asp 
            100                 105                 110         


Ala Pro Pro Leu Pro Val Pro Gly Val Leu Leu Lys Glu Phe Thr Val 
        115                 120                 125             


Ser Gly Asn Ile Leu Thr Ile Arg Leu Thr Ala Ala Asp His Arg Gln 
    130                 135                 140                 


Leu Gln Leu Ser Ile Ser Ser Cys Leu Gln Gln Leu Ser Leu Leu Met 
145                 150                 155                 160 


Trp Ile Thr Gln Cys Phe Leu Pro Val Phe Leu Ala Gln Pro Pro Ser 
                165                 170                 175     


Gly Gln Arg Arg 
            180 


<210>  47
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  47

Phe Ser Gly Ala Leu Asp Val Leu Gln Met Lys Glu Glu Asp Val Leu 
1               5                   10                  15      


Lys Phe Leu Ala Ala Gly Thr His Leu Gly Gly Thr Asn Leu Asp Phe 
            20                  25                  30          


Gln Met Glu Gln Tyr Ile Tyr Lys Arg Lys Ser Asp Gly Ile Tyr Ile 
        35                  40                  45              


Ile Asn Leu Lys Arg Thr Trp Glu Lys Leu Leu Leu Ala Ala Arg Ala 
    50                  55                  60                  


Ile Val Ala Ile Glu Asn Pro Ala Asp Val Ser Val Ile Ser Ser Arg 
65                  70                  75                  80  


Asn Thr Gly Gln Arg Ala Val Leu Lys Phe Ala Ala Ala Thr Gly Ala 
                85                  90                  95      


Thr Pro Ile Ala Gly Arg Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile 
            100                 105                 110         


Gln Ala Ala Phe Arg Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg 
        115                 120                 125             


Ala Asp His Gln Pro Leu Thr Glu Ala Ser Tyr Val Asn Leu Pro Thr 
    130                 135                 140                 


Ile Ala Leu Cys Asn Thr Asp Ser Pro Leu Arg Tyr Val Asp Ile Ala 
145                 150                 155                 160 


Ile Pro Cys Asn Asn Lys Gly Ala Ala His Ser Val Gly Leu Met Trp 
                165                 170                 175     


Trp Met Leu Ala Arg Glu Val Leu Arg Met Arg Gly Thr Ile Ser Arg 
            180                 185                 190         


Glu His Pro Trp Glu Val Met Pro Asp Leu Tyr Phe Tyr Arg Asp Pro 
        195                 200                 205             


Glu Glu Ile Glu Lys Glu Glu Gln Ala Ala Ala Glu Lys Ala Val Thr 
    210                 215                 220                 


Lys Glu Glu Phe Gln Gly Glu Trp Thr Ala Pro Ala Pro Glu Phe Thr 
225                 230                 235                 240 


Ala Thr Gln Pro Glu Val Ala Asp Trp Ser Glu Gly Val Gln Val Pro 
                245                 250                 255     


Ser Val Pro Ile Gln Gln Phe Pro Thr Glu Asp Trp Ser Ala Gln Pro 
            260                 265                 270         


Ala Thr Glu Asp Trp Ser Ala Ala Pro Thr Ala Gln Ala Thr Glu Trp 
        275                 280                 285             


Val Gly Ala Thr Thr Asp Trp Ser 
    290                 295     


<210>  48
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  48

Gly Ser Asp Val Arg Asp Leu Asn Ala Leu Leu Pro Ala Val Pro Ser 
1               5                   10                  15      


Leu Gly Gly Gly Gly Gly Cys Ala Leu Pro Val Ser Gly Ala Ala Gln 
            20                  25                  30          


Trp Ala Pro Val Leu Asp Phe Ala Pro Pro Gly Ala Ser Ala Tyr Gly 
        35                  40                  45              


Ser Leu Gly Gly Pro Ala Pro Pro Pro Ala Pro Pro Pro Pro Pro Pro 
    50                  55                  60                  


Pro Pro Pro His Ser Phe Ile Lys Gln Glu Pro Ser Trp Gly Gly Ala 
65                  70                  75                  80  


Glu Pro His Glu Glu Gln Cys Leu Ser Ala Phe Thr Val His Phe Ser 
                85                  90                  95      


Gly Gln Phe Thr Gly Thr Ala Gly Ala Cys Arg Tyr Gly Pro Phe Gly 
            100                 105                 110         


Pro Pro Pro Pro Ser Gln Ala Ser Ser Gly Gln Ala Arg Met Phe Pro 
        115                 120                 125             


Asn Ala Pro Tyr Leu Pro Ser Cys Leu Glu Ser Gln Pro Ala Ile Arg 
    130                 135                 140                 


Asn Gln Gly Tyr Ser Thr Val Thr Phe Asp Gly Thr Pro Ser Tyr Gly 
145                 150                 155                 160 


His Thr Pro Ser His His Ala Ala Gln Phe Pro Asn His Ser Phe Lys 
                165                 170                 175     


His Glu Asp Pro Met Gly Gln Gln Gly Ser Leu Gly Glu Gln Gln Tyr 
            180                 185                 190         


Ser Val Pro Pro Pro Val Tyr Gly Cys His Thr Pro Thr Asp Ser Cys 
        195                 200                 205             


Thr Gly Ser Gln Ala Leu Leu Leu Arg Thr Pro Tyr Ser Ser Asp Asn 
    210                 215                 220                 


Leu Tyr Gln Met Thr Ser Gln Leu Glu Cys Met Thr Trp Asn Gln Met 
225                 230                 235                 240 


Asn Leu Gly Ala Thr Leu Lys Gly Val Ala Ala Gly Ser Ser Ser Ser 
                245                 250                 255     


Val Lys Trp Thr Glu Gly Gln Ser Asn His Ser Thr Gly Tyr Glu Ser 
            260                 265                 270         


Asp Asn His Thr Thr Pro Ile 
        275                 


<210>  49
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Gly Gly His Gln Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu Leu 
1               5                   10                  15      


Met Ala Thr Leu Gln Ala Gly Phe Gly Arg Thr Gly Leu Val Leu Ala 
            20                  25                  30          


Ala Ala Val Glu Ser Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile Arg 
        35                  40                  45              


Val Ile Pro Leu Lys Met Asp Pro Thr Gly Lys Leu Asn Leu Thr Leu 
    50                  55                  60                  


Glu Gly Val Phe Ala Gly Val Ala Glu Ile Thr Pro Ala Glu Gly Lys 
65                  70                  75                  80  


Leu Met Gln Ser His Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp Asp 
                85                  90                  95      


Asn Leu Glu Pro Gly Phe Ile Ser Ile Val Lys Leu Glu Ser Pro Arg 
            100                 105                 110         


Arg Ala Pro Ala His Pro Leu Ile Cys Gly Pro Pro Gly Leu Asp Lys 
        115                 120                 125             


Arg Leu Leu Pro Glu Thr Pro Gly Pro Cys Tyr Ser Asn Ser Gln Pro 
    130                 135                 140                 


Val Trp Leu Cys Leu Thr Pro Arg Gln Pro Leu Glu Pro His Pro Pro 
145                 150                 155                 160 


Gly Glu Gly Pro Ser Glu Trp Ser Ser Asp Thr Ala Glu Gly Arg Pro 
                165                 170                 175     


Cys Pro Tyr Pro His Cys Gln Val Leu Ser Ala Gln Pro Gly Ser Glu 
            180                 185                 190         


Glu Glu Leu Glu Glu Leu Cys Glu Gln Ala Val Ser Gly Gly His Gln 
        195                 200                 205             


Leu Gln Leu Ala Ala Leu Trp Pro Trp Leu Leu Met Ala Thr Leu Gln 
    210                 215                 220                 


Ala Gly Phe Gly Arg Thr Gly Leu Val Leu Ala Ala Ala Val Glu Ser 
225                 230                 235                 240 


Glu Arg Ser Ala Glu Gln Lys Ala Ile Ile Arg Val Ile Pro Leu Lys 
                245                 250                 255     


Met Asp Pro Thr Gly Lys Leu Asn Leu Thr Leu Glu Gly Val Phe Ala 
            260                 265                 270         


Gly Val Ala Glu Ile Thr Pro Ala Glu Gly Lys Leu Met Gln Ser His 
        275                 280                 285             


Pro Leu Tyr Leu Cys Asn Ala Ser Asp Asp Asp Asn Leu Glu Pro Gly 
    290                 295                 300                 


Phe Ile Ser Ile Val Lys Leu Glu Ser Pro Arg Arg Ala Pro Ala His 
305                 310                 315                 320 


Pro Leu Ile Cys Gly Pro Pro Gly Leu Asp Lys Arg Leu Leu Pro Glu 
                325                 330                 335     


Thr Pro Gly Pro Cys Tyr Ser Asn Ser Gln Pro Val Trp Leu Cys Leu 
            340                 345                 350         


Thr Pro Arg Gln Pro Leu Glu Pro His Pro Pro Gly Glu Gly Pro Ser 
        355                 360                 365             


Glu Trp Ser Ser Asp Thr Ala Glu Gly Arg Pro Cys Pro Tyr Pro His 
    370                 375                 380                 


Cys Gln Val Leu Ser Ala Gln Pro Gly Ser Glu Glu Glu Leu Glu Glu 
385                 390                 395                 400 


Leu Cys Glu Gln Ala Val 
                405     


<210>  50
<211>  284
<212>  PRT
<213>  Homo sapiens

<400>  50

Lys Leu Thr Ile Glu Ser Thr Pro Phe Asn Val Ala Glu Gly Lys Glu 
1               5                   10                  15      


Val Leu Leu Leu Val His Asn Leu Pro Gln His Leu Phe Gly Tyr Ser 
            20                  25                  30          


Trp Tyr Lys Gly Glu Arg Val Asp Gly Asn Arg Gln Ile Ile Gly Tyr 
        35                  40                  45              


Val Ile Gly Thr Gln Gln Ala Thr Pro Gly Pro Ala Tyr Ser Gly Arg 
    50                  55                  60                  


Glu Ile Ile Tyr Pro Asn Ala Ser Leu Leu Ile Gln Asn Ile Ile Gln 
65                  70                  75                  80  


Asn Asp Thr Gly Phe Tyr Thr Leu His Val Ile Lys Ser Asp Leu Val 
                85                  90                  95      


Asn Glu Glu Ala Thr Gly Gln Phe Arg Val Tyr Pro Glu Leu Pro Lys 
            100                 105                 110         


Pro Ser Ile Ser Ser Asn Asn Ser Lys Pro Val Glu Asp Lys Asp Ala 
        115                 120                 125             


Val Ala Phe Thr Cys Glu Pro Glu Thr Gln Asp Ala Thr Tyr Leu Trp 
    130                 135                 140                 


Trp Val Asn Asn Gln Ser Leu Pro Val Ser Pro Arg Leu Gln Leu Ser 
145                 150                 155                 160 


Asn Gly Asn Arg Thr Leu Thr Leu Phe Asn Val Thr Arg Asn Asp Thr 
                165                 170                 175     


Ala Ser Tyr Lys Cys Glu Thr Gln Asn Pro Val Ser Ala Arg Arg Ser 
            180                 185                 190         


Asp Ser Val Ile Leu Asn Val Leu Tyr Gly Pro Asp Thr Pro Ile Ile 
        195                 200                 205             


Ser Pro Pro Asp Ser Ser Tyr Leu Ser Gly Ala Asn Leu Asn Leu Ser 
    210                 215                 220                 


Cys His Ser Ala Ser Asn Pro Ser Pro Gln Tyr Ser Trp Phe Val Asn 
225                 230                 235                 240 


Gly Thr Phe Gln Gln His Thr Gln Val Leu Leu Ile Ala Lys Ile Gln 
                245                 250                 255     


Pro Asn Asn Asn Gly Thr Tyr Ala Cys Phe Val Ser Asn Leu Ala Thr 
            260                 265                 270         


Gly Arg Asn Asn Ser Ile Val Lys Ser Ile Thr Val 
        275                 280                 


<210>  51
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein CD40L47-261-TPE-E7

<400>  51

Met His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu 
1               5                   10                  15      


Asp Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg 
            20                  25                  30          


Ser Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly 
        35                  40                  45              


Phe Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn 
    50                  55                  60                  


Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His 
65                  70                  75                  80  


Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala 
                85                  90                  95      


Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn 
            100                 105                 110         


Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala 
        115                 120                 125             


Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe 
    130                 135                 140                 


Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu 
145                 150                 155                 160 


Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln 
                165                 170                 175     


Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val 
            180                 185                 190         


Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe 
        195                 200                 205             


Thr Ser Phe Gly Leu Leu Lys Leu Glu Phe Gly Ser Glu Leu Glu Ala 
    210                 215                 220                 


Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys 
225                 230                 235                 240 


Arg Ala Arg Tyr Lys Arg Gly Trp Glu Gln Leu Glu Gln Cys Gly Tyr 
                245                 250                 255     


Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg Leu Ser Trp 
            260                 265                 270         


Thr Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val 
        275                 280                 285             


Pro Arg Gly Ser His Met His Gly Asp Thr Pro Thr Leu His Glu Tyr 
    290                 295                 300                 


Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys Tyr Glu Gln 
305                 310                 315                 320 


Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly 
                325                 330                 335     


Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
            340                 345                 350         


Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp 
        355                 360                 365             


Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys 
    370                 375                 380                 


Pro Ile Cys Ser Gln Lys Pro Ala Glu Ala Ala Ala Ala Lys Glu Ala 
385                 390                 395                 400 


Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys 
                405                 410                 415     


Ala His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu His Leu Glu 
            420                 425                 430         


Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu Gln Leu Ser 
        435                 440                 445             


Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn His Gln His 
    450                 455                 460                 


Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met Leu Cys Met 
465                 470                 475                 480 


Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu Ser Ser Ala 
                485                 490                 495     


Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr Leu Ser Phe 
            500                 505                 510         


Val Cys Pro Trp Cys Ala Ser Gln Gln Thr Arg Ala Lys Asp Glu Leu 
        515                 520                 525             


<210>  52
<211>  467
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein 18sCD40L-TPE-E7

<400>  52

Met Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile 
1               5                   10                  15      


Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu 
            20                  25                  30          


Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr 
        35                  40                  45              


Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr 
    50                  55                  60                  


Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln 
65                  70                  75                  80  


Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu 
                85                  90                  95      


Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys 
            100                 105                 110         


Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly 
        115                 120                 125             


Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly 
    130                 135                 140                 


Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu Glu Phe Gly Ser Glu 
145                 150                 155                 160 


Leu Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
                165                 170                 175     


Ala Ala Lys Arg Ala Arg Tyr Lys Arg Gly Trp Glu Gln Leu Glu Gln 
            180                 185                 190         


Cys Gly Tyr Pro Val Gln Arg Leu Val Ala Leu Tyr Leu Ala Ala Arg 
        195                 200                 205             


Leu Ser Trp Thr Met Gly Ser Ser His His His His His His Ser Ser 
    210                 215                 220                 


Gly Leu Val Pro Arg Gly Ser His Met His Gly Asp Thr Pro Thr Leu 
225                 230                 235                 240 


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
                245                 250                 255     


Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly 
            260                 265                 270         


Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr 
        275                 280                 285             


Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr 
    290                 295                 300                 


His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly 
305                 310                 315                 320 


Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala Glu Ala Ala Ala Ala 
                325                 330                 335     


Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
            340                 345                 350         


Ala Ala Lys Ala His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu 
        355                 360                 365             


His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu 
    370                 375                 380                 


Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn 
385                 390                 395                 400 


His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met 
                405                 410                 415     


Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu 
            420                 425                 430         


Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr 
        435                 440                 445             


Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln Thr Arg Ala Lys 
    450                 455                 460                 


Asp Glu Leu 
465         


<210>  53
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein E7-TStx-CD40L47-261

<400>  53

Met Lys Leu Thr Met Gly Ser Ser His His His His His His Ser Ser 
1               5                   10                  15      


Gly Leu Val Pro Arg Gly Ser His Met His Gly Asp Thr Pro Thr Leu 
            20                  25                  30          


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        35                  40                  45              


Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly 
    50                  55                  60                  


Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr 
65                  70                  75                  80  


Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr 
                85                  90                  95      


His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly 
            100                 105                 110         


Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
    130                 135                 140                 


Ala Ala Lys Ala His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu 
145                 150                 155                 160 


His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu 
                165                 170                 175     


Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn 
            180                 185                 190         


His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met 
        195                 200                 205             


Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu 
    210                 215                 220                 


Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr 
225                 230                 235                 240 


Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln Thr Arg Ala Pro 
                245                 250                 255     


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
            260                 265                 270         


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
        275                 280                 285             


His His Ala Ser Arg Val Ala Arg Glu Phe Gly Ser Glu Leu Glu Ala 
    290                 295                 300                 


Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys 
305                 310                 315                 320 


His Arg Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp 
                325                 330                 335     


Phe Val Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser 
            340                 345                 350         


Leu Ser Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe 
        355                 360                 365             


Val Lys Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser 
    370                 375                 380                 


Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val 
385                 390                 395                 400 


Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu 
                405                 410                 415     


Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly 
            420                 425                 430         


Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln 
        435                 440                 445             


Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile 
    450                 455                 460                 


Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu 
465                 470                 475                 480 


Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser 
                485                 490                 495     


Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe 
            500                 505                 510         


Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr 
        515                 520                 525             


Ser Phe Gly Leu Leu Lys Leu 
    530                 535 


<210>  54
<211>  474
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein E7-TStx-18sCD40L

<400>  54

Met Lys Leu Thr Met Gly Ser Ser His His His His His His Ser Ser 
1               5                   10                  15      


Gly Leu Val Pro Arg Gly Ser His Met His Gly Asp Thr Pro Thr Leu 
            20                  25                  30          


His Glu Tyr Met Leu Asp Leu Gln Pro Glu Thr Thr Asp Leu Tyr Cys 
        35                  40                  45              


Tyr Glu Gln Leu Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly 
    50                  55                  60                  


Pro Ala Gly Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr 
65                  70                  75                  80  


Phe Cys Cys Lys Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr 
                85                  90                  95      


His Val Asp Ile Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly 
            100                 105                 110         


Ile Val Cys Pro Ile Cys Ser Gln Lys Pro Ala Glu Ala Ala Ala Ala 
        115                 120                 125             


Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
    130                 135                 140                 


Ala Ala Lys Ala His Gly Pro Lys Ala Thr Leu Gln Asp Ile Val Leu 
145                 150                 155                 160 


His Leu Glu Pro Gln Asn Glu Ile Pro Val Asp Leu Leu Cys His Glu 
                165                 170                 175     


Gln Leu Ser Asp Ser Glu Glu Glu Asn Asp Glu Ile Asp Gly Val Asn 
            180                 185                 190         


His Gln His Leu Pro Ala Arg Arg Ala Glu Pro Gln Arg His Thr Met 
        195                 200                 205             


Leu Cys Met Cys Cys Lys Cys Glu Ala Arg Ile Lys Leu Val Val Glu 
    210                 215                 220                 


Ser Ser Ala Asp Asp Leu Arg Ala Phe Gln Gln Leu Phe Leu Asn Thr 
225                 230                 235                 240 


Leu Ser Phe Val Cys Pro Trp Cys Ala Ser Gln Gln Thr Arg Ala Pro 
                245                 250                 255     


Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile Ser Phe Gly 
            260                 265                 270         


Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu Asn Cys His 
        275                 280                 285             


His His Ala Ser Arg Val Ala Arg Glu Phe Gly Ser Glu Leu Glu Ala 
    290                 295                 300                 


Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys 
305                 310                 315                 320 


Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala 
                325                 330                 335     


Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln 
            340                 345                 350         


Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu 
        355                 360                 365             


Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile 
    370                 375                 380                 


Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala 
385                 390                 395                 400 


Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg 
                405                 410                 415     


Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly 
            420                 425                 430         


Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala 
        435                 440                 445             


Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser His Gly Thr 
    450                 455                 460                 


Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
465                 470                 


<210>  55
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein HBx-preS1-TStx-18sCD40L

<400>  55

Met Lys Leu Thr Met Gly Ser Ser His His His His His His Ser Ser 
1               5                   10                  15      


Gly Leu Val Pro Arg Gly Ser His Met Ala Ala Arg Met Cys Cys Gln 
            20                  25                  30          


Leu Asp Pro Ala Arg Asp Val Leu Cys Leu Arg Pro Val Gly Ala Glu 
        35                  40                  45              


Ser Arg Gly Arg Pro Leu Pro Gly Pro Leu Gly Ala Leu Pro Pro Ser 
    50                  55                  60                  


Ser Ala Ser Ala Val Pro Ala Asp His Gly Ser His Leu Ser Leu Arg 
65                  70                  75                  80  


Gly Leu Pro Val Cys Ser Phe Ser Ser Ala Gly Pro Cys Ala Leu Arg 
                85                  90                  95      


Phe Thr Ser Ala Arg Arg Met Glu Thr Thr Val Asn Ala Pro Trp Ser 
            100                 105                 110         


Leu Pro Thr Val Leu His Lys Arg Thr Ile Gly Leu Ser Gly Arg Ser 
        115                 120                 125             


Met Thr Trp Ile Glu Glu Tyr Ile Lys Asp Cys Val Phe Lys Asp Trp 
    130                 135                 140                 


Glu Glu Leu Gly Glu Glu Ile Arg Leu Lys Val Phe Val Leu Gly Gly 
145                 150                 155                 160 


Cys Arg His Lys Leu Val Cys Ser Pro Ala Pro Cys Asn Phe Phe Thr 
                165                 170                 175     


Ser Ala Arg Gly Arg Ala Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala 
            180                 185                 190         


Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Ala Glu 
        195                 200                 205             


Phe Met Gly Gly Trp Ser Ser Lys Pro Arg Gln Gly Met Gly Thr Asn 
    210                 215                 220                 


Leu Ser Val Pro Asn Pro Leu Gly Phe Phe Pro Asp His Gln Leu Asp 
225                 230                 235                 240 


Pro Ala Phe Gly Ala Asn Ser Asn Asn Pro Asp Trp Asp Phe Asn Pro 
                245                 250                 255     


Asn Lys Asp His Trp Pro Glu Ala Asn Gln Val Gly Ala Gly Ala Phe 
            260                 265                 270         


Gly Pro Gly Phe Thr Pro Pro His Gly Gly Leu Leu Gly Trp Ser Pro 
        275                 280                 285             


Gln Ala Gln Gly Ile Leu Thr Thr Val Pro Ala Ala Pro Pro Pro Ala 
    290                 295                 300                 


Ser Thr Asn Arg Gln Ser Gly Arg Gln Pro Thr Pro Ile Glu Leu Thr 
305                 310                 315                 320 


Arg Ala Pro Asp Tyr His Gly Gln Asp Ser Val Arg Val Gly Arg Ile 
                325                 330                 335     


Ser Phe Gly Ser Ile Asn Ala Ile Leu Gly Ser Val Ala Leu Ile Leu 
            340                 345                 350         


Asn Cys His His His Ala Ser Arg Val Ala Arg Glu Phe Gly Ser Glu 
        355                 360                 365             


Leu Glu Ala Ala Ala Ala Lys Glu Ala Ala Ala Ala Lys Glu Ala Ala 
    370                 375                 380                 


Ala Ala Lys Glu Asn Ser Phe Glu Met Gln Lys Gly Asp Gln Asn Pro 
385                 390                 395                 400 


Gln Ile Ala Ala His Val Ile Ser Glu Ala Ser Ser Lys Thr Thr Ser 
                405                 410                 415     


Val Leu Gln Trp Ala Glu Lys Gly Tyr Tyr Thr Met Ser Asn Asn Leu 
            420                 425                 430         


Val Thr Leu Glu Asn Gly Lys Gln Leu Thr Val Lys Arg Gln Gly Leu 
        435                 440                 445             


Tyr Tyr Ile Tyr Ala Gln Val Thr Phe Cys Ser Asn Arg Glu Ala Ser 
    450                 455                 460                 


Ser Gln Ala Pro Phe Ile Ala Ser Leu Cys Leu Lys Ser Pro Gly Arg 
465                 470                 475                 480 


Phe Glu Arg Ile Leu Leu Arg Ala Ala Asn Thr His Ser Ser Ala Lys 
                485                 490                 495     


Pro Cys Gly Gln Gln Ser Ile His Leu Gly Gly Val Phe Glu Leu Gln 
            500                 505                 510         


Pro Gly Ala Ser Val Phe Val Asn Val Thr Asp Pro Ser Gln Val Ser 
        515                 520                 525             


His Gly Thr Gly Phe Thr Ser Phe Gly Leu Leu Lys Leu 
    530                 535                 540     


<210>  56
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rigid linker 1 with n=1

<400>  56

Glu Ala Ala Ala Ala Lys 
1               5       


