                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  ABERRANT POST-TRANSLATIONAL MODIFICATIONS (PTMS) IN METHYL- AND 
       PROPIONIC ACIDEMIA AND A MUTANT SIRTUIN (SIRT) TO METABOLIZE PTMS

<130>  4239-103809-02

<150>  US 63/021,179
<151>  2020-05-07

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  3393
<212>  DNA
<213>  Homo sapiens

<400>  1
attcgggggc gcgagctgcc ccagtaaatg gaaatgtttt ctaacatata aaaacctaca       60

gaagaagaaa ataattttct ggatcaaatt agaagtctgt attatattga tgtctccaga      120

ttcaaatata ttagaaagca gccgtggaga caaccatctt cattttggga gaaataacta      180

aagcccgcct caagcattag aactacagac aaaccctgat gcgacctctc cagattgtcc      240

caagtcgatt gatttcccag ctatattgtg gcctgaagcc tccagcgtcc acacgaaacc      300

agatttgcct gaaaatggct cggccaagtt caagtatggc agattttcga aagttttttg      360

caaaagcaaa gcacatagtc atcatctcag gagctggtgt tagtgcagaa agtggtgttc      420

cgaccttcag aggagctgga ggttattgga gaaaatggca agcccaggac ctggcgactc      480

ccctggcctt tgcccacaac ccgtcccggg tgtgggagtt ctaccactac cggcgggagg      540

tcatggggag caaggagccc aacgccgggc accgcgccat agccgagtgt gagacccggc      600

tgggcaagca gggccggcga gtcgtggtca tcacccagaa catcgatgag ctgcaccgca      660

aggctggcac caagaacctt ctggagatcc atggtagctt atttaaaact cgatgtacct      720

cttgtggagt tgtggctgag aattacaaga gtccaatttg tccagcttta tcaggaaaag      780

gtgctccaga acctggaact caagatgcca gcatcccagt tgagaaactt ccccggtgtg      840

aagaggcagg ctgcgggggc ttgctgcgac ctcacgtcgt gtggtttgga gaaaacctgg      900

atcctgccat tctggaggag gttgacagag agctcgccca ctgtgattta tgtctagtgg      960

tgggcacttc ctctgtggtg tacccagcag ccatgtttgc cccccaggtg gctgccaggg     1020

gcgtgccagt ggctgaattt aacacggaga ccaccccagc tacgaacaga ttcaggtttc     1080

atttccaggg accctgtgga acgactcttc ctgaagccct tgcctgtcat gaaaatgaaa     1140

ctgtttctta agtgtcctgg ggaagaaaga aattacagta tatctaagaa ctaggccaca     1200

cgcagaggag aaatggtctt atgggtggtg agctgagtac tgaacaatct aaaaatagcc     1260

tctgattccc tcgctggaat ccaacctgtt gataagtgat gggggtttag aagtagcaaa     1320

gagcacccac attcaaaagt cacagaactg gaaagttaat tcatattatt tggtttgaac     1380

tgaaacgtga ggtatctttg atgtgtatgg ttggttattg ggagggaaaa attttgtaaa     1440

ttagattgtc taaaaaaaat agttattctg attatatttt tgttatctgg gcaaagtaga     1500

agtcaagggg taaaaaccct actattctga tttttgcaca agttttagtg gaaaataaaa     1560

tcacactcta cagtaggtaa tttattgtat aaagacatta ccccacgata tggctttatt     1620

agggactttt tttttttttt tttgagacag agtttcactc ttgttgccca ggctggagtg     1680

cagtggtgcg atctcagctc acagcaacct ccgcctcccg ggttcaagag attctcctgc     1740

ctcagcctca tgagtagctg ggattacagg tatgtaccac cacacccagc taattttgta     1800

tttttagtag agacggggtt tctccatgtt ggtcaggctg gtcttaaact ctcgacctca     1860

ggtgatctgc ccgcctcggc ctcccaaagt gctgagatta cgggcatgag ccaccgcacc     1920

cggcttactg ggggcttttt aaccttgttt ggctacatta cctcagtgaa caaggggaag     1980

ctcacaacag gaactcacac aaagaaggaa gagaacagta ccaacaaggt agaacatcac     2040

gatgagaaga aagaatgatg caaatatgtg gacccccagg ataaacacag ctgcccaaaa     2100

tttagctctg gcccccttag atgggggaag tcaacagtga agtgtttctc agcatcataa     2160

aggcagaagc tgtggttcct gtggggcctg ccaaccgttc ccagatgctg aactctgctg     2220

ggagtttttt ccatgggact ttaaaaaatg atgcccttag gttgggccag acctctgtta     2280

acttcagtag ggatggcacc aggttcaaga ggccaaagaa gagacctgga gctagtgaag     2340

gaaacatagg gtttatttgg ggaaccttac agggtggtcc agtggccgcg ggctggacag     2400

aactgcaacc acttataaaa agcatgcagt ttacatagca ctttcactca gcaccctccc     2460

ctcagcagcc tccacgtggc aaccctcact tcttaagtta ttgctgtcag atgcatctgc     2520

catacagggt cattctcagg ggatgcttaa gttatttctg tcaggtacat cttccataca     2580

ctttactacc ttggagtaaa gtagtaagaa tacagctttt tccttaacct ttaccagcta     2640

actcagtgct taggggcctt ggaatgcctg ctgtccagca ggtgtcacag gcctgactgg     2700

gaggcatggc cattatcaac agtgtatgaa ggtcacatat ggctccctga agtgattaca     2760

tacttggacc acatcacctc agccccttgc aaaattgcat ttaatgttac acccttggct     2820

tttgtagaaa caggcaacaa gacactatca tataaaactt tgtactgcat tgcaaggcat     2880

aacctttaat aaatcccagt ggtcctttgt gtagggaacg gggatgctca tagcctatgg     2940

ggcggctgga gaaccagtca gggaccctga gggctcgatg tacactttac atgggtgggc     3000

caaggagttt acactgaggg cactggtaat acctgtaata gtcttatagt acttataaag     3060

cagttttgca cataaaatac catcatgcac ttataagttt gttcttgggc tgctccaagt     3120

taactttatt cattttccta gtgttagtgt ctcagggagt ctgattatat ttttgatttg     3180

taatttctat ctgactaagg cctagagatt tcaaaactgt tctttgcaat tcctctcata     3240

ctgaacctct ggttcagcag ctttttttgt tgttgttgtt ttcaagtttt atcatttttg     3300

ttcctatttg gttttgtcgt ttttaaattg agaattgctt ctaaaacaga agacatgaaa     3360

agagaattaa aaatacaata tatgtgtaag ata                                  3393


<210>  2
<211>  310
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser 
305                 310 


<210>  3
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  3
atgcgacctc tccagattgt cccaagtcga ttgatttccc agctatattg tggcctgaag       60

cctccagcgt ccacacgaaa ccagatttgc ctgaaaatgg ctcggccaag ttcaagtatg      120

gcagattttc gaaagttttt tgcaaaagca aagcacatag tcatcatctc aggagctggt      180

gttagtgcag aaagtggtgt tccgaccttc agaggagctg gaggttattg gagaagatgg      240

caagcccagg acctggcgac tcccctggcc tttgcccaca acccgtcccg ggtgtgggag      300

ttctaccact accggcggga ggtcatgggg agcagggagc ccaacgccgg gcaccgcgcc      360

atagccgagt gtgagacccg gctgggcaag cagggccggc gagtcgtggt catcacccag      420

aacatcgatg agctgcatcg cagggctggc accaggaacc ttctggagat ccatggtagc      480

ttatttaaaa ctcgatgtac ctcttgtgga gttgtggctg agaattacaa gagtccaatt      540

tgtccagctt tatcaggaaa aggtgctcca gaacctggaa ctcaagatgc cagcatccca      600

gttgagaaac ttccccggtg tgaagaggca ggctgcgggg gcttgctgcg acctcacgtc      660

gtgtggtttg gagaaaacct ggatcctgcc attctggagg aggttgacag agagctcgcc      720

cactgtgatt tatgtctagt ggtgggcact tcctctgtgg tgtacccagc agccatgttt      780

gccccccagg tggctgccag gggcgtgcca gtggctgaat ttaacacgga gaccacccca      840

gctacgaaca gattcaggtt tcatttccag ggaccctgtg gaacgactct tcctgaagcc      900

cttgcctgtc atgaaaatga aactgtttct                                       930


<210>  4
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein

<400>  4

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Arg Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Arg 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Arg Ala Gly Thr Arg Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser 
305                 310 


<210>  5
<211>  4503
<212>  DNA
<213>  Homo sapiens

<400>  5
atgacgagga ttttgacagc tttcaaagtg gtgaggacac tgaagactgg ttttggcttt       60

accaatgtga ctgcacacca aaaatggaaa ttttcaagac ctggcatcag gctcctttct      120

gtcaaggcac agacagcaca cattgtcctg gaagatggaa ctaagatgaa aggttactcc      180

tttggccatc catcctctgt tgctggtgaa gtggttttta atactggcct gggagggtac      240

ccagaagcta ttactgaccc tgcctacaaa ggacagattc tcacaatggc caaccctatt      300

attgggaatg gtggagctcc tgatactact gctctggatg aactgggact tagcaaatat      360

ttggagtcta atggaatcaa ggtttcaggt ttgctggtgc tggattatag taaagactac      420

aaccactggc tggctaccaa gagtttaggg caatggctac aggaagaaaa ggttcctgca      480

atttatggag tggacacaag aatgctgact aaaataattc gggataaggg taccatgctt      540

gggaagattg aatttgaagg tcagcctgtg gattttgtgg atccaaataa acagaatttg      600

attgctgagg tttcaaccaa ggatgtcaaa gtgtacggca aaggaaaccc cacaaaagtg      660

gtagctgtag actgtgggat taaaaacaat gtaatccgcc tgctagtaaa gcgaggagct      720

gaagtgcact tagttccctg gaaccatgat ttcaccaaga tggagtatga tgggattttg      780

atcgcgggag gaccggggaa cccagctctt gcagaaccac taattcagaa tgtcagaaag      840

attttggaga gtgatcgcaa ggagccattg tttggaatca gtacaggaaa cttaataaca      900

ggattggctg ctggtgccaa aacctacaag atgtccatgg ccaacagagg gcagaatcag      960

cctgttttga atatcacaaa caaacaggct ttcattactg ctcagaatca tggctatgcc     1020

ttggacaaca ccctccctgc tggctggaaa ccactttttg tgaatgtcaa cgatcaaaca     1080

aatgagggga ttatgcatga gagcaaaccc ttcttcgctg tgcagttcca cccagaggtc     1140

accccggggc caatagacac tgagtacctg tttgattcct ttttctcact gataaagaaa     1200

ggaaaagcta ccaccattac atcagtctta ccgaagccag cactagttgc atctcgggtt     1260

gaggtttcca aagtccttat tctaggatca ggaggtctgt ccattggtca ggctggagaa     1320

tttgattact caggatctca agctgtaaaa gccatgaagg aagaaaatgt caaaactgtt     1380

ctgatgaacc caaacattgc atcagtccag accaatgagg tgggcttaaa gcaagcggat     1440

actgtctact ttcttcccat cacccctcag tttgtcacag aggtcatcaa ggcagaacag     1500

ccagatgggt taattctggg catgggtggc cagacagctc tgaactgtgg agtggaacta     1560

ttcaagagag gtgtgctcaa ggaatatggt gtgaaagtcc tgggaacttc agttgagtcc     1620

attatggcta cggaagacag gcagctgttt tcagataaac taaatgagat caatgaaaag     1680

attgctccaa gttttgcagt ggaatcgatt gaggatgcac tgaaggcagc agacaccatt     1740

ggctacccag tgatgatccg ttccgcctat gcactgggtg ggttaggctc aggcatctgt     1800

cccaacagag agactttgat ggacctcagc acaaaggcct ttgctatgac caaccaaatt     1860

ctggtggaga agtcagtgac aggttggaaa gaaatagaat atgaagtggt tcgagatgct     1920

gatgacaatt gtgtcactgt ctgtaacatg gaaaatgttg atgccatggg tgttcacaca     1980

ggtgactcag ttgttgtggc tcctgcccag acactctcca atgccgagtt tcagatgttg     2040

agacgtactt caatcaatgt tgttcgccac ttgggcattg tgggtgaatg caacattcag     2100

tttgcccttc atcctacctc aatggaatac tgcatcattg aagtgaatgc cagactgtcc     2160

cgaagctctg ctctggcctc aaaagccact ggctacccat tggcattcat tgctgcaaag     2220

attgccctag gaatcccact tccagaaatt aagaacgtcg tatccgggaa gacatcagcc     2280

tgttttgaac ctagcctgga ttacatggtc accaagattc cccgctggga tcttgaccgt     2340

tttcatggaa catctagccg aattggtagc tctatgaaaa gtgtaggaga ggtcatggct     2400

attggtcgta cctttgagga gagtttccag aaagctttac ggatgtgcca cccatctata     2460

gaaggtttca ctccccgtct cccaatgaac aaagaatggc catctaattt agatcttaga     2520

aaagagttgt ctgaaccaag cagcacgcgt atctatgcca ttgccaaggc cattgatgac     2580

aacatgtccc ttgatgagat tgagaagctc acatacattg acaagtggtt tttgtataag     2640

atgcgtgata ttttaaacat ggaaaagaca ctgaaaggcc tcaacagtga gtccatgaca     2700

gaagaaaccc tgaaaagggc aaaggagatt gggttctcag ataagcagat ttcaaaatgc     2760

cttgggctca ctgaggccca gacaagggag ctgaggttaa agaaaaacat ccacccttgg     2820

gttaaacaga ttgatacact ggctgcagaa tacccatcag taacaaacta tctctatgtt     2880

acctacaatg gtcaggagca tgatgtcaat tttgatgacc atggaatgat ggtgctaggc     2940

tgtggtccat atcacattgg cagcagtgtg gaatttgatt ggtgtgctgt ctctagtatc     3000

cgcacactgc gtcaacttgg caagaagacg gtggtggtga attgcaatcc tgagactgtg     3060

agcacagact ttgatgagtg tgacaaactg tactttgaag agttgtcctt ggagagaatc     3120

ctagacatct accatcagga ggcatgtggt ggctgcatca tatcagttgg aggccagatt     3180

ccaaacaacc tggcagttcc tctatacaag aatggtgtca agatcatggg cacaagcccc     3240

ctgcagatcg acagggctga ggatcgctcc atcttctcag ctgtcttgga tgagctgaag     3300

gtggctcagg caccttggaa agctgttaat actttgaatg aagcactgga atttgcaaag     3360

tctgtggact acccctgctt gttgaggcct tcctatgttt tgagtgggtc tgctatgaat     3420

gtggtattct ctgaggatga gatgaaaaaa ttcctagaag aggcgactag agtttctcag     3480

gagcacccag tggtgctgac aaaatttgtt gaaggggccc gagaagtaga aatggacgct     3540

gttggcaaag atggaagggt tatctctcat gccatctctg aacatgttga agatgcaggt     3600

gtccactcgg gagatgccac tctgatgctg cccacacaaa ccatcagcca aggggccatt     3660

gaaaaggtga aggatgctac ccggaagatt gcaaaggctt ttgccatctc tggtccattc     3720

aacgtccaat ttcttgtcaa aggaaatgat gtcttggtga ttgagtgtaa cttgagagct     3780

tctcgatcct tcccctttgt ttccaagact cttggggttg acttcattga tgtggccacc     3840

aaggtgatga ttggagagaa tgttgatgag aaacatcttc caacattgga ccatcccata     3900

attcctgctg actatgttgc aattaaggct cccatgtttt cctggccccg gttgagggat     3960

gctgacccca ttctgagatg tgagatggct tccactggag aggtggcttg ctttggtgaa     4020

ggtattcata cagccttcct aaaggcaatg ctttccacag gatttaagat accccagaaa     4080

ggcatcctga taggcatcca gcaatcattc cggccaagat tccttggtgt ggctgaacaa     4140

ttacacaatg aaggtttcaa gctgtttgcc acggaagcca catcagactg gctcaacgcc     4200

aacaatgtcc ctgccacccc agtggcatgg ccgtctcaag aaggacagaa tcccagcctc     4260

tcttccatca gaaaattgat tagagatggc agcattgacc tagtgattaa ccttcccaac     4320

aacaacacta aatttgtcca tgataattat gtgattcgga ggacagctgt tgatagtgga     4380

atccctctcc tcactaattt tcaggtgacc aaactttttg ctgaagctgt gcagaaatct     4440

cgcaaggtgg actccaagag tcttttccac tacaggcagt acagtgctgg aaaagcagca     4500

tag                                                                   4503


<210>  6
<211>  1500
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu Leu Ser Val Lys Ala Gln Thr Ala His Ile 
        35                  40                  45              


Val Leu Glu Asp Gly Thr Lys Met Lys Gly Tyr Ser Phe Gly His Pro 
    50                  55                  60                  


Ser Ser Val Ala Gly Glu Val Val Phe Asn Thr Gly Leu Gly Gly Tyr 
65                  70                  75                  80  


Pro Glu Ala Ile Thr Asp Pro Ala Tyr Lys Gly Gln Ile Leu Thr Met 
                85                  90                  95      


Ala Asn Pro Ile Ile Gly Asn Gly Gly Ala Pro Asp Thr Thr Ala Leu 
            100                 105                 110         


Asp Glu Leu Gly Leu Ser Lys Tyr Leu Glu Ser Asn Gly Ile Lys Val 
        115                 120                 125             


Ser Gly Leu Leu Val Leu Asp Tyr Ser Lys Asp Tyr Asn His Trp Leu 
    130                 135                 140                 


Ala Thr Lys Ser Leu Gly Gln Trp Leu Gln Glu Glu Lys Val Pro Ala 
145                 150                 155                 160 


Ile Tyr Gly Val Asp Thr Arg Met Leu Thr Lys Ile Ile Arg Asp Lys 
                165                 170                 175     


Gly Thr Met Leu Gly Lys Ile Glu Phe Glu Gly Gln Pro Val Asp Phe 
            180                 185                 190         


Val Asp Pro Asn Lys Gln Asn Leu Ile Ala Glu Val Ser Thr Lys Asp 
        195                 200                 205             


Val Lys Val Tyr Gly Lys Gly Asn Pro Thr Lys Val Val Ala Val Asp 
    210                 215                 220                 


Cys Gly Ile Lys Asn Asn Val Ile Arg Leu Leu Val Lys Arg Gly Ala 
225                 230                 235                 240 


Glu Val His Leu Val Pro Trp Asn His Asp Phe Thr Lys Met Glu Tyr 
                245                 250                 255     


Asp Gly Ile Leu Ile Ala Gly Gly Pro Gly Asn Pro Ala Leu Ala Glu 
            260                 265                 270         


Pro Leu Ile Gln Asn Val Arg Lys Ile Leu Glu Ser Asp Arg Lys Glu 
        275                 280                 285             


Pro Leu Phe Gly Ile Ser Thr Gly Asn Leu Ile Thr Gly Leu Ala Ala 
    290                 295                 300                 


Gly Ala Lys Thr Tyr Lys Met Ser Met Ala Asn Arg Gly Gln Asn Gln 
305                 310                 315                 320 


Pro Val Leu Asn Ile Thr Asn Lys Gln Ala Phe Ile Thr Ala Gln Asn 
                325                 330                 335     


His Gly Tyr Ala Leu Asp Asn Thr Leu Pro Ala Gly Trp Lys Pro Leu 
            340                 345                 350         


Phe Val Asn Val Asn Asp Gln Thr Asn Glu Gly Ile Met His Glu Ser 
        355                 360                 365             


Lys Pro Phe Phe Ala Val Gln Phe His Pro Glu Val Thr Pro Gly Pro 
    370                 375                 380                 


Ile Asp Thr Glu Tyr Leu Phe Asp Ser Phe Phe Ser Leu Ile Lys Lys 
385                 390                 395                 400 


Gly Lys Ala Thr Thr Ile Thr Ser Val Leu Pro Lys Pro Ala Leu Val 
                405                 410                 415     


Ala Ser Arg Val Glu Val Ser Lys Val Leu Ile Leu Gly Ser Gly Gly 
            420                 425                 430         


Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly Ser Gln Ala 
        435                 440                 445             


Val Lys Ala Met Lys Glu Glu Asn Val Lys Thr Val Leu Met Asn Pro 
    450                 455                 460                 


Asn Ile Ala Ser Val Gln Thr Asn Glu Val Gly Leu Lys Gln Ala Asp 
465                 470                 475                 480 


Thr Val Tyr Phe Leu Pro Ile Thr Pro Gln Phe Val Thr Glu Val Ile 
                485                 490                 495     


Lys Ala Glu Gln Pro Asp Gly Leu Ile Leu Gly Met Gly Gly Gln Thr 
            500                 505                 510         


Ala Leu Asn Cys Gly Val Glu Leu Phe Lys Arg Gly Val Leu Lys Glu 
        515                 520                 525             


Tyr Gly Val Lys Val Leu Gly Thr Ser Val Glu Ser Ile Met Ala Thr 
    530                 535                 540                 


Glu Asp Arg Gln Leu Phe Ser Asp Lys Leu Asn Glu Ile Asn Glu Lys 
545                 550                 555                 560 


Ile Ala Pro Ser Phe Ala Val Glu Ser Ile Glu Asp Ala Leu Lys Ala 
                565                 570                 575     


Ala Asp Thr Ile Gly Tyr Pro Val Met Ile Arg Ser Ala Tyr Ala Leu 
            580                 585                 590         


Gly Gly Leu Gly Ser Gly Ile Cys Pro Asn Arg Glu Thr Leu Met Asp 
        595                 600                 605             


Leu Ser Thr Lys Ala Phe Ala Met Thr Asn Gln Ile Leu Val Glu Lys 
    610                 615                 620                 


Ser Val Thr Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
625                 630                 635                 640 


Asp Asp Asn Cys Val Thr Val Cys Asn Met Glu Asn Val Asp Ala Met 
                645                 650                 655     


Gly Val His Thr Gly Asp Ser Val Val Val Ala Pro Ala Gln Thr Leu 
            660                 665                 670         


Ser Asn Ala Glu Phe Gln Met Leu Arg Arg Thr Ser Ile Asn Val Val 
        675                 680                 685             


Arg His Leu Gly Ile Val Gly Glu Cys Asn Ile Gln Phe Ala Leu His 
    690                 695                 700                 


Pro Thr Ser Met Glu Tyr Cys Ile Ile Glu Val Asn Ala Arg Leu Ser 
705                 710                 715                 720 


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Phe 
                725                 730                 735     


Ile Ala Ala Lys Ile Ala Leu Gly Ile Pro Leu Pro Glu Ile Lys Asn 
            740                 745                 750         


Val Val Ser Gly Lys Thr Ser Ala Cys Phe Glu Pro Ser Leu Asp Tyr 
        755                 760                 765             


Met Val Thr Lys Ile Pro Arg Trp Asp Leu Asp Arg Phe His Gly Thr 
    770                 775                 780                 


Ser Ser Arg Ile Gly Ser Ser Met Lys Ser Val Gly Glu Val Met Ala 
785                 790                 795                 800 


Ile Gly Arg Thr Phe Glu Glu Ser Phe Gln Lys Ala Leu Arg Met Cys 
                805                 810                 815     


His Pro Ser Ile Glu Gly Phe Thr Pro Arg Leu Pro Met Asn Lys Glu 
            820                 825                 830         


Trp Pro Ser Asn Leu Asp Leu Arg Lys Glu Leu Ser Glu Pro Ser Ser 
        835                 840                 845             


Thr Arg Ile Tyr Ala Ile Ala Lys Ala Ile Asp Asp Asn Met Ser Leu 
    850                 855                 860                 


Asp Glu Ile Glu Lys Leu Thr Tyr Ile Asp Lys Trp Phe Leu Tyr Lys 
865                 870                 875                 880 


Met Arg Asp Ile Leu Asn Met Glu Lys Thr Leu Lys Gly Leu Asn Ser 
                885                 890                 895     


Glu Ser Met Thr Glu Glu Thr Leu Lys Arg Ala Lys Glu Ile Gly Phe 
            900                 905                 910         


Ser Asp Lys Gln Ile Ser Lys Cys Leu Gly Leu Thr Glu Ala Gln Thr 
        915                 920                 925             


Arg Glu Leu Arg Leu Lys Lys Asn Ile His Pro Trp Val Lys Gln Ile 
    930                 935                 940                 


Asp Thr Leu Ala Ala Glu Tyr Pro Ser Val Thr Asn Tyr Leu Tyr Val 
945                 950                 955                 960 


Thr Tyr Asn Gly Gln Glu His Asp Val Asn Phe Asp Asp His Gly Met 
                965                 970                 975     


Met Val Leu Gly Cys Gly Pro Tyr His Ile Gly Ser Ser Val Glu Phe 
            980                 985                 990         


Asp Trp Cys Ala Val Ser Ser Ile  Arg Thr Leu Arg Gln  Leu Gly Lys 
        995                 1000                 1005             


Lys Thr  Val Val Val Asn Cys  Asn Pro Glu Thr Val  Ser Thr Asp 
    1010                 1015                 1020             


Phe Asp  Glu Cys Asp Lys Leu  Tyr Phe Glu Glu Leu  Ser Leu Glu 
    1025                 1030                 1035             


Arg Ile  Leu Asp Ile Tyr His  Gln Glu Ala Cys Gly  Gly Cys Ile 
    1040                 1045                 1050             


Ile Ser  Val Gly Gly Gln Ile  Pro Asn Asn Leu Ala  Val Pro Leu 
    1055                 1060                 1065             


Tyr Lys  Asn Gly Val Lys Ile  Met Gly Thr Ser Pro  Leu Gln Ile 
    1070                 1075                 1080             


Asp Arg  Ala Glu Asp Arg Ser  Ile Phe Ser Ala Val  Leu Asp Glu 
    1085                 1090                 1095             


Leu Lys  Val Ala Gln Ala Pro  Trp Lys Ala Val Asn  Thr Leu Asn 
    1100                 1105                 1110             


Glu Ala  Leu Glu Phe Ala Lys  Ser Val Asp Tyr Pro  Cys Leu Leu 
    1115                 1120                 1125             


Arg Pro  Ser Tyr Val Leu Ser  Gly Ser Ala Met Asn  Val Val Phe 
    1130                 1135                 1140             


Ser Glu  Asp Glu Met Lys Lys  Phe Leu Glu Glu Ala  Thr Arg Val 
    1145                 1150                 1155             


Ser Gln  Glu His Pro Val Val  Leu Thr Lys Phe Val  Glu Gly Ala 
    1160                 1165                 1170             


Arg Glu  Val Glu Met Asp Ala  Val Gly Lys Asp Gly  Arg Val Ile 
    1175                 1180                 1185             


Ser His  Ala Ile Ser Glu His  Val Glu Asp Ala Gly  Val His Ser 
    1190                 1195                 1200             


Gly Asp  Ala Thr Leu Met Leu  Pro Thr Gln Thr Ile  Ser Gln Gly 
    1205                 1210                 1215             


Ala Ile  Glu Lys Val Lys Asp  Ala Thr Arg Lys Ile  Ala Lys Ala 
    1220                 1225                 1230             


Phe Ala  Ile Ser Gly Pro Phe  Asn Val Gln Phe Leu  Val Lys Gly 
    1235                 1240                 1245             


Asn Asp  Val Leu Val Ile Glu  Cys Asn Leu Arg Ala  Ser Arg Ser 
    1250                 1255                 1260             


Phe Pro  Phe Val Ser Lys Thr  Leu Gly Val Asp Phe  Ile Asp Val 
    1265                 1270                 1275             


Ala Thr  Lys Val Met Ile Gly  Glu Asn Val Asp Glu  Lys His Leu 
    1280                 1285                 1290             


Pro Thr  Leu Asp His Pro Ile  Ile Pro Ala Asp Tyr  Val Ala Ile 
    1295                 1300                 1305             


Lys Ala  Pro Met Phe Ser Trp  Pro Arg Leu Arg Asp  Ala Asp Pro 
    1310                 1315                 1320             


Ile Leu  Arg Cys Glu Met Ala  Ser Thr Gly Glu Val  Ala Cys Phe 
    1325                 1330                 1335             


Gly Glu  Gly Ile His Thr Ala  Phe Leu Lys Ala Met  Leu Ser Thr 
    1340                 1345                 1350             


Gly Phe  Lys Ile Pro Gln Lys  Gly Ile Leu Ile Gly  Ile Gln Gln 
    1355                 1360                 1365             


Ser Phe  Arg Pro Arg Phe Leu  Gly Val Ala Glu Gln  Leu His Asn 
    1370                 1375                 1380             


Glu Gly  Phe Lys Leu Phe Ala  Thr Glu Ala Thr Ser  Asp Trp Leu 
    1385                 1390                 1395             


Asn Ala  Asn Asn Val Pro Ala  Thr Pro Val Ala Trp  Pro Ser Gln 
    1400                 1405                 1410             


Glu Gly  Gln Asn Pro Ser Leu  Ser Ser Ile Arg Lys  Leu Ile Arg 
    1415                 1420                 1425             


Asp Gly  Ser Ile Asp Leu Val  Ile Asn Leu Pro Asn  Asn Asn Thr 
    1430                 1435                 1440             


Lys Phe  Val His Asp Asn Tyr  Val Ile Arg Arg Thr  Ala Val Asp 
    1445                 1450                 1455             


Ser Gly  Ile Pro Leu Leu Thr  Asn Phe Gln Val Thr  Lys Leu Phe 
    1460                 1465                 1470             


Ala Glu  Ala Val Gln Lys Ser  Arg Lys Val Asp Ser  Lys Ser Leu 
    1475                 1480                 1485             


Phe His  Tyr Arg Gln Tyr Ser  Ala Gly Lys Ala Ala  
    1490                 1495                 1500 


<210>  7
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  7
atgcgacctc tccagattgt cccaagtcga ttgatttccc agctatattg tggcctgaag       60

cctccagcgt ccacacgaaa ccagatttgc ctgaaaatgg ctcggccaag ttcaagtatg      120

gcagattttc gaaagttttt tgcaaaagca aagcacatag tcatcatctc aggagctggt      180

gttagtgcag aaagtggtgt tccgaccttc agaggagctg gaggttattg gagaaaatgg      240

caagcccagg acctggcgac tcccctggcc tttgcccaca acccgtcccg ggtgtgggag      300

ttctaccact accggcggga ggtcatgggg agcaaggagc ccaacgccgg gcaccgcgcc      360

atagccgagt gtgagacccg gctgggcaag cagggccggc gagtcgtggt catcacccag      420

aacatcgatg agctgcaccg caaggctggc accaagaacc ttctggagat ccatggtagc      480

ttatttaaaa ctcgatgtac ctcttgtgga gttgtggctg agaattacaa gagtccaatt      540

tgtccagctt tatcaggaaa aggtgctcca gaacctggaa ctcaagatgc cagcatccca      600

gttgagaaac ttccccggtg tgaagaggca ggctgcgggg gcttgctgcg acctcacgtc      660

gtgtggtttg gagaaaacct ggatcctgcc attctggagg aggttgacag agagctcgcc      720

cactgtgatt tatgtctagt ggtgggcact tcctctgtgg tgtacccagc agccatgttt      780

gccccccagg tggctgccag gggcgtgcca gtggctgaat ttaacacgga gaccacccca      840

gctacgaaca gattcaggtt tcatttccag ggaccctgtg gaacgactct tcctgaagcc      900

cttgcctgtc atgaaaatga aactgtttct gaattcggag gagactacaa ggacgacgat      960

gacaagtaa                                                              969


<210>  8
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein

<400>  8

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Lys Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Lys 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Lys Ala Gly Thr Lys Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser Glu Phe Gly Gly Asp Tyr Lys Asp Asp Asp 
305                 310                 315                 320 


Asp Lys 
        


<210>  9
<211>  969
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  9
atgcgacctc tccagattgt cccaagtcga ttgatttccc agctatattg tggcctgaag       60

cctccagcgt ccacacgaaa ccagatttgc ctgaaaatgg ctcggccaag ttcaagtatg      120

gcagattttc gaaagttttt tgcaaaagca aagcacatag tcatcatctc aggagctggt      180

gttagtgcag aaagtggtgt tccgaccttc agaggagctg gaggttattg gagaagatgg      240

caagcccagg acctggcgac tcccctggcc tttgcccaca acccgtcccg ggtgtgggag      300

ttctaccact accggcggga ggtcatgggg agcagggagc ccaacgccgg gcaccgcgcc      360

atagccgagt gtgagacccg gctgggcaag cagggccggc gagtcgtggt catcacccag      420

aacatcgatg agctgcatcg cagggctggc accaggaacc ttctggagat ccatggtagc      480

ttatttaaaa ctcgatgtac ctcttgtgga gttgtggctg agaattacaa gagtccaatt      540

tgtccagctt tatcaggaaa aggtgctcca gaacctggaa ctcaagatgc cagcatccca      600

gttgagaaac ttccccggtg tgaagaggca ggctgcgggg gcttgctgcg acctcacgtc      660

gtgtggtttg gagaaaacct ggatcctgcc attctggagg aggttgacag agagctcgcc      720

cactgtgatt tatgtctagt ggtgggcact tcctctgtgg tgtacccagc agccatgttt      780

gccccccagg tggctgccag gggcgtgcca gtggctgaat ttaacacgga gaccacccca      840

gctacgaaca gattcaggtt tcatttccag ggaccctgtg gaacgactct tcctgaagcc      900

cttgcctgtc atgaaaatga aactgtttct gaattcggag gagactacaa ggacgacgat      960

gacaagtaa                                                              969


<210>  10
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Recombinant protein

<400>  10

Met Arg Pro Leu Gln Ile Val Pro Ser Arg Leu Ile Ser Gln Leu Tyr 
1               5                   10                  15      


Cys Gly Leu Lys Pro Pro Ala Ser Thr Arg Asn Gln Ile Cys Leu Lys 
            20                  25                  30          


Met Ala Arg Pro Ser Ser Ser Met Ala Asp Phe Arg Lys Phe Phe Ala 
        35                  40                  45              


Lys Ala Lys His Ile Val Ile Ile Ser Gly Ala Gly Val Ser Ala Glu 
    50                  55                  60                  


Ser Gly Val Pro Thr Phe Arg Gly Ala Gly Gly Tyr Trp Arg Arg Trp 
65                  70                  75                  80  


Gln Ala Gln Asp Leu Ala Thr Pro Leu Ala Phe Ala His Asn Pro Ser 
                85                  90                  95      


Arg Val Trp Glu Phe Tyr His Tyr Arg Arg Glu Val Met Gly Ser Arg 
            100                 105                 110         


Glu Pro Asn Ala Gly His Arg Ala Ile Ala Glu Cys Glu Thr Arg Leu 
        115                 120                 125             


Gly Lys Gln Gly Arg Arg Val Val Val Ile Thr Gln Asn Ile Asp Glu 
    130                 135                 140                 


Leu His Arg Arg Ala Gly Thr Arg Asn Leu Leu Glu Ile His Gly Ser 
145                 150                 155                 160 


Leu Phe Lys Thr Arg Cys Thr Ser Cys Gly Val Val Ala Glu Asn Tyr 
                165                 170                 175     


Lys Ser Pro Ile Cys Pro Ala Leu Ser Gly Lys Gly Ala Pro Glu Pro 
            180                 185                 190         


Gly Thr Gln Asp Ala Ser Ile Pro Val Glu Lys Leu Pro Arg Cys Glu 
        195                 200                 205             


Glu Ala Gly Cys Gly Gly Leu Leu Arg Pro His Val Val Trp Phe Gly 
    210                 215                 220                 


Glu Asn Leu Asp Pro Ala Ile Leu Glu Glu Val Asp Arg Glu Leu Ala 
225                 230                 235                 240 


His Cys Asp Leu Cys Leu Val Val Gly Thr Ser Ser Val Val Tyr Pro 
                245                 250                 255     


Ala Ala Met Phe Ala Pro Gln Val Ala Ala Arg Gly Val Pro Val Ala 
            260                 265                 270         


Glu Phe Asn Thr Glu Thr Thr Pro Ala Thr Asn Arg Phe Arg Phe His 
        275                 280                 285             


Phe Gln Gly Pro Cys Gly Thr Thr Leu Pro Glu Ala Leu Ala Cys His 
    290                 295                 300                 


Glu Asn Glu Thr Val Ser Glu Phe Gly Gly Asp Tyr Lys Asp Asp Asp 
305                 310                 315                 320 


Asp Lys 
        


<210>  11
<211>  5186
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  11
ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta agagaattat       60

gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg acaacgatcg      120

gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta actcgccttg      180

atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac accacgatgc      240

ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt actctagctt      300

cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca cttctgcgct      360

cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag cgtggaagcc      420

gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta gttatctaca      480

cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag ataggtgcct      540

cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt tagattgatt      600

taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat aatctcatga      660

ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta gaaaagatca      720

aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa acaaaaaaac      780

caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt tttccgaagg      840

taactggctt cagcagagcg cagataccaa atactgttct tctagtgtag ccgtagttag      900

gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta atcctgttac      960

cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca agacgatagt     1020

taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag cccagcttgg     1080

agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa agcgccacgc     1140

ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga acaggagagc     1200

gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc gggtttcgcc     1260

acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc ctatggaaaa     1320

acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt gctcacatgt     1380

cctgcaggca gctgcgcgct cgctcgctca ctgaggccgc ccgggcaaag cccgggcgtc     1440

gggcgacctt tggtcgcccg gcctcagtga gcgagcgagc gcgcagagag ggagtggcca     1500

actccatcac taggggttcc ttctagacaa ctttgtatag aaaagttggg gctggaagct     1560

acctttgaca tcatttcctc tgcgaatgca tgtataattt ctacagaacc tattagaaag     1620

gatcacccag cctctgcttt tgtacaactt tcccttaaaa aactgccaat tccactgctg     1680

tttggcccaa tagtgagaac tttttcctgc tgcctcttgg tgcttttgcc tatggcccct     1740

attctgcctg ctgaagacac tcttgccagc atggacttaa acccctccag ctctgacaat     1800

cctctttctc ttttgtttta catgaagggt ctggcagcca aagcaatcac tcaaagttca     1860

aaccttatca ttttttgctt tgttcctctt ggccttggtt ttgtacatca gctttgaaaa     1920

taccatccca gggttaatgc tggggttaat ttataactaa gagtgctcta gttttgcaat     1980

acaggacatg ctataaaaat ggaaagatca agtttgtaca aaaaagcagg ctgccaccat     2040

gcgacctctc cagattgtcc caagtcgatt gatttcccag ctatattgtg gcctgaagcc     2100

tccagcgtcc acacgaaacc agatttgcct gaaaatggct cggccaagtt caagtatggc     2160

agattttcga aagttttttg caaaagcaaa gcacatagtc atcatctcag gagctggtgt     2220

tagtgcagaa agtggtgttc cgaccttcag aggagctgga ggttattgga gaagatggca     2280

agcccaggac ctggcgactc ccctggcctt tgcccacaac ccgtcccggg tgtgggagtt     2340

ctaccactac cggcgggagg tcatggggag cagggagccc aacgccgggc accgcgccat     2400

agccgagtgt gagacccggc tgggcaagca gggccggcga gtcgtggtca tcacccagaa     2460

catcgatgag ctgcatcgca gggctggcac caggaacctt ctggagatcc atggtagctt     2520

atttaaaact cgatgtacct cttgtggagt tgtggctgag aattacaaga gtccaatttg     2580

tccagcttta tcaggaaaag gtgctccaga acctggaact caagatgcca gcatcccagt     2640

tgagaaactt ccccggtgtg aagaggcagg ctgcgggggc ttgctgcgac ctcacgtcgt     2700

gtggtttgga gaaaacctgg atcctgccat tctggaggag gttgacagag agctcgccca     2760

ctgtgattta tgtctagtgg tgggcacttc ctctgtggtg tacccagcag ccatgtttgc     2820

cccccaggtg gctgccaggg gcgtgccagt ggctgaattt aacacggaga ccaccccagc     2880

tacgaacaga ttcaggtttc atttccaggg accctgtgga acgactcttc ctgaagccct     2940

tgcctgtcat gaaaatgaaa ctgtttctga attcggagga gactacaagg acgacgatga     3000

caagtaaacc cagctttctt gtacaaagtg ggaattccga taatcaacct ctggattaca     3060

aaatttgtga aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat     3120

acgctgcttt aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct     3180

ccttgtataa atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac     3240

gtggcgtggt gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca     3300

cctgtcagct cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca     3360

tcgccgcctg ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg     3420

tggtgttgtc ggggaagctg acgtcctttc catggctgct cgcctgtgtt gccacctgga     3480

ttctgcgcgg gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt     3540

cccgcggcct gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga     3600

gtcggatctc cctttgggcc gcctccccgc atcgggaatt cctagagctc gctgatcagc     3660

ctcgactgtg ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt     3720

gaccctggaa ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca     3780

ttgtctgagt aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga     3840

ggattgggaa gagaatagca ggcatgctgg ggagggccgc aggaacccct agtgatggag     3900

ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc     3960

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag ctgcctgcag     4020

gggcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatacgt     4080

caaagcaacc atagtacgcg ccctgtagcg gcgcattaag cgcggcgggt gtggtggtta     4140

cgcgcagcgt gaccgctaca cttgccagcg ccttagcgcc cgctcctttc gctttcttcc     4200

cttcctttct cgccacgttc gccggctttc cccgtcaagc tctaaatcgg gggctccctt     4260

tagggttccg atttagtgct ttacggcacc tcgaccccaa aaaacttgat ttgggtgatg     4320

gttcacgtag tgggccatcg ccctgataga cggtttttcg ccctttgacg ttggagtcca     4380

cgttctttaa tagtggactc ttgttccaaa ctggaacaac actcaactct atctcgggct     4440

attcttttga tttataaggg attttgccga tttcggtcta ttggttaaaa aatgagctga     4500

tttaacaaaa atttaacgcg aattttaaca aaatattaac gtttacaatt ttatggtgca     4560

ctctcagtac aatctgctct gatgccgcat agttaagcca gccccgacac ccgccaacac     4620

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     4680

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgagac     4740

gaaagggcct cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt     4800

agacgtcagg tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct     4860

aaatacattc aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat     4920

attgaaaaag gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg     4980

cggcattttg ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg     5040

aagatcagtt gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc     5100

ttgagagttt tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat     5160

gtggcgcggt attatcccgt attgac                                          5186


<210>  12
<211>  6122
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Recombinant nucleic acid

<400>  12
tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc gcaacgcaat taatgtgagt       60

tagctcactc attaggcacc ccaggcttta cactttatgc ttccggctcg tatgttgtgt      120

ggaattgtga gcggataaca atttcacaca ggaaacagct atgaccatga ttacgccaga      180

tttaattaag gccttaatta ggctgcgcgc tcgctcgctc actgaggccg cccgggcaaa      240

gcccgggcgt cgggcgacct ttggtcgccc ggcctcagtg agcgagcgag cgcgcagaga      300

gggagtggcc aactccatca ctaggggttc cttgtagtta atgattaacc cgccatgcta      360

cttatctacc agggtaatgg ggatcctcta gaactatagc tagtcgacat tgattattga      420

ctagttatta atagtaatca attacggggt cattagttca tagcccatat atggagttcc      480

gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac ccccgcccat      540

tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc cattgacgtc      600

aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg tatcatatgc      660

caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat tatgcccagt      720

acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc atcgctatta      780

ccatggtcga ggtgagcccc acgttctgct tcactctccc catctccccc ccctccccac      840

ccccaatttt gtatttattt attttttaat tattttgtgc agcgatgggg gcgggggggg      900

ggggggggcg cgcgccaggc ggggcggggc ggggcgaggg gcggggcggg gcgaggcgga      960

gaggtgcggc ggcagccaat cagagcggcg cgctccgaaa gtttcctttt atggcgaggc     1020

ggcggcggcg gcggccctat aaaaagcgaa gcgcgcggcg ggcgggagtc gctgcgcgct     1080

gccttcgccc cgtgccccgc tccgccgccg cctcgcgccg cccgccccgg ctctgactga     1140

ccgcgttact cccacaggtg agcgggcggg acggcccttc tcctccgggc tgtaattagc     1200

gcttggttta atgacggctt gtttcttttc tgtggctgcg tgaaagcctt gaggggctcc     1260

gggagggccc tttgtgcggg gggagcggct cggggggtgc gtgcgtgtgt gtgtgcgtgg     1320

ggagcgccgc gtgcggctcc gcgctgcccg gcggctgtga gcgctgcggg cgcggcgcgg     1380

ggctttgtgc gctccgcagt gtgcgcgagg ggagcgcggc cgggggcggt gccccgcggt     1440

gcgggggggg ctgcgagggg aacaaaggct gcgtgcgggg tgtgtgcgtg ggggggtgag     1500

cagggggtgt gggcgcgtcg gtcgggctgc aaccccccct gcacccccct ccccgagttg     1560

ctgagcacgg cccggcttcg ggtgcggggc tccgtacggg gcgtggcgcg gggctcgccg     1620

tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg ggcggggccg cctcgggccg     1680

gggagggctc gggggagggg cgcggcggcc cccggagcgc cggcggctgt cgaggcgcgg     1740

cgagccgcag ccattgcctt ttatggtaat cgtgcgagag ggcgcaggga cttcctttgt     1800

cccaaatctg tgcggagccg aaatctggga ggcgccgccg caccccctct agcgggcgcg     1860

gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg ggagggcctt cgtgcgtcgc     1920

cgcgccgccg tccccttctc cctctccagc ctcggggctg tccgcggggg gacggctgcc     1980

ttcggggggg acggggcagg gcggggttcg gcttctggcg tgtgaccggc ggctctagag     2040

cctctgctaa ccatgttcat gccttcttct ttttcctaca gctcctgggc aacgtgctgg     2100

ttattgtgct gtctcatcat tttggcaaag aattcgatat cgccgccacc atgcgacctc     2160

tccagattgt cccaagtcga ttgatttccc agctatattg tggcctgaag cctccagcgt     2220

ccacacgaaa ccagatttgc ctgaaaatgg ctcggccaag ttcaagtatg gcagattttc     2280

gaaagttttt tgcaaaagca aagcacatag tcatcatctc aggagctggt gttagtgcag     2340

aaagtggtgt tccgaccttc agaggagctg gaggttattg gagaagatgg caagcccagg     2400

acctggcgac tcccctggcc tttgcccaca acccgtcccg ggtgtgggag ttctaccact     2460

accggcggga ggtcatgggg agcagggagc ccaacgccgg gcaccgcgcc atagccgagt     2520

gtgagacccg gctgggcaag cagggccggc gagtcgtggt catcacccag aacatcgatg     2580

agctgcatcg cagggctggc accaggaacc ttctggagat ccatggtagc ttatttaaaa     2640

ctcgatgtac ctcttgtgga gttgtggctg agaattacaa gagtccaatt tgtccagctt     2700

tatcaggaaa aggtgctcca gaacctggaa ctcaagatgc cagcatccca gttgagaaac     2760

ttccccggtg tgaagaggca ggctgcgggg gcttgctgcg acctcacgtc gtgtggtttg     2820

gagaaaacct ggatcctgcc attctggagg aggttgacag agagctcgcc cactgtgatt     2880

tatgtctagt ggtgggcact tcctctgtgg tgtacccagc agccatgttt gccccccagg     2940

tggctgccag gggcgtgcca gtggctgaat ttaacacgga gaccacccca gctacgaaca     3000

gattcaggtt tcatttccag ggaccctgtg gaacgactct tcctgaagcc cttgcctgtc     3060

atgaaaatga aactgtttct gaattcggag gagactacaa ggacgacgat gacaagtaaa     3120

agcttctcga ggacggggtg aactacgcct gaggatccga tctttttccc tctgccaaaa     3180

attatgggga catcatgaag ccccttgagc atctgacttc tggctaataa aggaaattta     3240

ttttcattgc aatagtgtgt tggaattttt tgtgtctctc actcggaagc aattcgttga     3300

tctgaatttc gaccacccat aatacccatt accctggtag ataagtagca tggcgggtta     3360

atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc     3420

tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc     3480

tcagtgagcg agcgagcgcg cagccttaat taacctaatt cactggccgt cgttttacaa     3540

cgtcgtgact gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct     3600

ttcgccagct ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc     3660

agcctgaatg gcgaatggga cgcgccctgt agcggcgcat taagcgcggc gggtgtggtg     3720

gttacgcgca gcgtgaccgc tacacttgcc agcgccctag cgcccgctcc tttcgctttc     3780

ttcccttcct ttctcgccac gttcgccggc tttccccgtc aagctctaaa tcgggggctc     3840

cctttagggt tccgatttag tgctttacgg cacctcgacc ccaaaaaact tgattagggt     3900

gatggttcac gtagtgggcc atcgccctga tagacggttt ttcgcccttt gacgttggag     3960

tccacgttct ttaatagtgg actcttgttc caaactggaa caacactcaa ccctatctcg     4020

gtctattctt ttgatttata agggattttg ccgatttcgg cctattggtt aaaaaatgag     4080

ctgatttaac aaaaatttaa cgcgaatttt aacaaaatat taacgcttac aatttaggtg     4140

gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa atacattcaa     4200

atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat tgaaaaagga     4260

agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg gcattttgcc     4320

ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa gatcagttgg     4380

gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc     4440

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat     4500

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg     4560

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag     4620

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa     4680

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc     4740

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca     4800

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc     4860

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc     4920

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg     4980

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta     5040

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag     5100

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga     5160

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc     5220

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa     5280

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa     5340

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     5400

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     5460

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     5520

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     5580

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     5640

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     5700

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     5760

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     5820

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     5880

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     5940

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     6000

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     6060

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     6120

gc                                                                    6122


<210>  13
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  13
gttattggag aagatggcaa gcc                                               23


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  14
ggcttgccat cttctccaat aac                                               23


<210>  15
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  15
catggggagc agggagccca acg                                               23


<210>  16
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  16
cgttgggctc cctgctcccc atg                                               23


<210>  17
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  17
ctgcaccgca gggctggcac caggaacctt ctg                                    33


<210>  18
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  18
cagaaggttc ctggtgccag ccctgcggtg cag                                    33


<210>  19
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  20

Asn Ala Asn Asn Pro Asp Trp Asp Phe 
1               5                   


<210>  21
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21

Cys Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10      


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  22

Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  23

Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  24

Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  25

Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  26
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  26

Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  27
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  27

Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  28
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  29
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  30
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  30

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  31
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  31

Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  32
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  32

Arg Gln Ile Lys Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  33

Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  34
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  34

Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  35
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  35

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  36
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  36

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  37
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  37

Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  38
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  38

Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  39
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  39

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  40
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  40

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  41

Pro Phe Val Tyr Leu Ile 
1               5       


<210>  42
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  42

Lys Lys Ala Lys Asn Lys Gln Leu Gly His Glu Glu Asp Tyr Ala Leu 
1               5                   10                  15      


Gly Lys Asp 
            


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  43

Lys Lys Lys Glu Lys Glu Val Lys Lys 
1               5                   


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  44

Lys Thr Ala His Ile Val Leu Glu Asp Gly Thr Lys Met Lys Gly 
1               5                   10                  15  


<210>  45
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  45

Lys Ile Ser Leu Pro His Pro Met Glu Ile Gly Glu Asn Leu Asp Gly 
1               5                   10                  15      


Thr Leu Lys Ser Arg Lys Arg Arg Lys 
            20                  25  


<210>  46
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  46

Lys Lys Lys Asn Asp Phe Glu Gln Gly Glu Leu Tyr Leu Lys Glu 
1               5                   10                  15  


<210>  47
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  47

Lys Asp Lys Tyr Lys Gln Ile Phe Leu Gly Gly Val Asp Lys Arg 
1               5                   10                  15  


<210>  48
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Lys Gly Lys Lys Leu Val Lys Lys Lys Ile Gly Lys Lys Asp Ala Gly 
1               5                   10                  15      


Lys Lys Glu Gly Lys Cys 
            20          


<210>  49
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  49

Lys Lys Asn Ser Glu Gly Leu Leu Lys Asn Lys Glu Lys Asn Gln Lys 
1               5                   10                  15      


Leu 
    


<210>  50
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  50

Lys Asp Ala Tyr Ile Lys Lys Gln Asn Leu Glu Lys Ala 
1               5                   10              


<210>  51
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  51

Lys Ala Phe Lys Asn Lys Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn 
1               5                   10                  15      


<210>  52
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  52

Lys Asp Val Glu Lys Lys Leu Asn Lys Val Thr Lys Phe 
1               5                   10              


<210>  53
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  53

Lys Glu Leu Gly Glu Lys Ile Ser Gln Leu Lys Asp Glu Leu Lys Thr 
1               5                   10                  15      


<210>  54
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  54

Lys Lys Ile Val Ala Glu Asn His Leu Lys Lys Ile 
1               5                   10          


<210>  55
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  55

Arg Lys Lys Val Glu Thr Glu Ala Lys Ile Lys Gln Lys Leu 
1               5                   10                  


<210>  56
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  56

Lys Lys Glu Thr Lys Gly Pro Ala Ala Glu Asn Leu Glu Ala Lys Pro 
1               5                   10                  15      


Val Gln Ala Pro Thr Val Lys Lys Ala Glu Lys Asp 
            20                  25              


<210>  57
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  57

Lys Lys Phe Gly Gly Gln Asp Ile Phe Met Thr Glu Glu Gln Lys Lys 
1               5                   10                  15      


Tyr Tyr Asn Ala Met Lys Lys Leu 
            20                  


<210>  58
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  58

Lys Lys Asp Thr Gln Thr Lys Ser Ile Ile Ser Glu Thr Ser Asn Lys 
1               5                   10                  15      


Ile Asp Thr Glu Ile Ala Ser Leu Lys Thr Leu Met Glu Ser Ser Lys 
            20                  25                  30          


Leu 
    


<210>  59
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  59

Lys Leu Gly Lys Met Asp Arg Val Val Leu Gly Trp Thr Ala Val Phe 
1               5                   10                  15      


Trp Leu Thr Ala Met Val Glu Gly Leu Gln Val Thr Val Pro Asp Lys 
            20                  25                  30          


Lys Lys 
        


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  60

Lys Tyr Lys Ile Lys Thr Ile Gln Asp Leu Val Ser Leu Lys Glu 
1               5                   10                  15  


<210>  61
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  61

Lys Arg Lys Met Arg Lys Gly Gln His Leu Asp Leu Lys Ala 
1               5                   10                  


