               SEQUENCE LISTING

<110> MOLECULAR PARTNERS AG

<120> Novel Ankyrin Repeat Binding Proteins And Their Uses

<130> P028

<160> 95

<170> BiSSAP 1.3.6

<210> 1
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 1
Gly Ser Asp Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Trp Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser Gln 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 2
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 2
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Trp Thr Pro Leu His Leu Ala Ala His Gln Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Phe Gly Arg Thr Pro Leu His Leu Ala Ala Trp Val 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Pro Ala Ala Ile 
            100                 105                 110         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 3
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 3
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 4
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 4
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Lys Ile Gly Val Thr Pro Leu His Ile Ala Ala Glu Val Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Val Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Ile Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
Phe Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Val Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 5
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 5
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 6
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 6
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu 
            100                 105                 110         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 7
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 7
Gly Ser Asp Leu Gly Leu Lys Leu Leu Thr Ala Ala Lys Gln Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Arg Gly Leu Thr Pro Leu His Tyr Ala Ala Ala Ile Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Gln Tyr Gly Ala Thr Pro Leu His Val Ala Ala Tyr Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Phe Ser Gly Ser Thr Pro Ala Asp Leu Ala Ala Glu 
            100                 105                 110         
Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 8
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 8
Gly Ser Asp Leu Gly Trp Lys Leu Leu Trp Ala Ala Gln Val Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Asp Leu Gly Trp Thr Pro Leu His Ile Ala Ala Trp Val Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Thr Gly Arg Thr Pro Leu His His Ala Ala Thr Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Lys Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Asp Val Gly His Thr Pro Ala Asp Leu Ala Ala Leu 
            100                 105                 110         
Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 9
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 9
Gly Ser Asp Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Val Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe 
            100                 105                 110         
Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 10
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 10
Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Trp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala Glu 
            100                 105                 110         
Ser Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 11
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 11
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Glu Thr Gly Phe Thr Pro Leu His Val Ala Ala Glu Lys Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp His Phe Gly Phe Thr Pro Leu His Leu Val Ser Glu Trp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Ser Tyr Gly Trp Thr Pro Leu His Val Ala Ala Ile 
            100                 105                 110         
Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
145                 150                 155                 

<210> 12
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 12
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Trp 
            500                 505                 510         
Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 13
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 13
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Ile Gly Val Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Glu Val Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ser Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Val Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ile Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Phe Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Val Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Trp Thr Pro Leu His Leu Ala Ala His Gln Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Phe Gly Arg Thr Pro Leu His Leu Ala Ala Trp Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Ser Gly Ala Thr Pro Leu His Pro Ala Ala Ile Tyr Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val 
            660                 665                 670         
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Trp Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr 
    690                 695                 700                 
Lys Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Val Gly Tyr Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Ser Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Gln Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 14
<211> 817
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 14
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Ile Gly Val Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Glu Val Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ser Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Val Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ile Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Phe Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Val Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala 
            660                 665                 670         
Gly Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln 
    690                 695                 700                 
Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala 
                725                 730                 735     
Trp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala 
        755                 760                 765             
Ala Leu His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly 
    770                 775                 780                 
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
785                 790                 795                 800 
Ala Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
                805                 810                 815     
Ala 
    

<210> 15
<211> 817
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 15
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala 
            660                 665                 670         
Gly Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln 
    690                 695                 700                 
His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala 
                725                 730                 735     
Trp Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala 
        755                 760                 765             
Ala Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
    770                 775                 780                 
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
785                 790                 795                 800 
Ala Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
                805                 810                 815     
Ala 
    

<210> 16
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 16
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Leu Lys Leu 
    290                 295                 300                 
Leu Thr Ala Ala Lys Gln Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Arg Gly Leu Thr Pro 
                325                 330                 335     
Leu His Tyr Ala Ala Ala Ile Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Tyr Gly Ala Thr 
        355                 360                 365             
Pro Leu His Val Ala Ala Tyr Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Phe Ser Gly Ser 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Glu Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 17
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 17
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Trp Lys Leu 
    290                 295                 300                 
Leu Trp Ala Ala Gln Val Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Leu Gly Trp Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Trp Val Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Thr Gly Arg Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Thr Glu Gly His Leu Glu Ile Val Lys Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asp Val Gly His 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Leu Trp Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Ile 
465                 470                 475                 480 
Gly Val Thr Pro Leu His Ile Ala Ala Glu Val Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ser Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Val Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ile Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu Phe Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Val Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Trp Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Gln Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 18
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 18
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Leu Lys Leu Leu Thr Ala Ala Lys Gln 
            660                 665                 670         
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Tyr Arg Gly Leu Thr Pro Leu His Tyr Ala Ala Ala 
    690                 695                 700                 
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Gln Tyr Gly Ala Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Tyr Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Phe Ser Gly Ser Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Glu Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 19
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 19
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Ile Gly Val Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Glu Val Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ser Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Val Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ile Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Phe Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Val Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Trp 
            500                 505                 510         
Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Trp Lys Leu Leu Trp Ala Ala Gln Val Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Asp Leu Gly Trp Thr Pro Leu His Ile Ala Ala Trp Val 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Phe Thr Gly Arg Thr Pro Leu His His Ala Ala Thr 
    690                 695                 700                 
Glu Gly His Leu Glu Ile Val Lys Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asp Val Gly His Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Leu Trp Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 20
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 20
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala 
            660                 665                 670         
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Val Ala Ala Val 
    690                 695                 700                 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala 
                725                 730                 735     
Arg Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Phe Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 21
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 21
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly His Lys Leu 
    290                 295                 300                 
Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Trp Ile Gly Ile 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 22
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 22
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Asn Lys Leu 
    290                 295                 300                 
Leu Asp Ala Ala Trp Val Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Trp Gln Gly Glu Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Thr Lys Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Val Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Val Ala Ala Ser Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Val His Gly Tyr 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Gln Ala Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg 
    690                 695                 700                 
Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Phe Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 23
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 23
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly His Lys Leu 
    290                 295                 300                 
Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Trp Ile Gly Ile 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Trp Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Gln Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 24
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 24
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Glu Ser Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 25
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 25
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Glu Thr Gly Phe Thr Pro Leu His Val Ala Ala Glu Lys 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp His Phe Gly Phe Thr Pro Leu His Leu Val Ser Glu 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Ser Tyr Gly Trp Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Ile Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 26
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 26
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu 
    290                 295                 300                 
Leu His Ala Ala Gln Tyr Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly Gln 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe 
465                 470                 475                 480 
Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr 
                565                 570                 575     
Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
            580                 585                 590         
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
        595                 600                 605             
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
    610                 615                 620                 
Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly 
625                 630                 635                 640 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu 
    690                 695                 700                 
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 27
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 27
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Thr Gly Phe Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Glu Lys Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Phe Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Val Ser Glu Trp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Tyr Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Ile Leu Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 28
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 28
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala His Gln Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Arg Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Ser Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Asn Lys Leu Leu Asp Ala Ala Trp Val Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Trp 
            500                 505                 510         
Gln Gly Glu Thr Pro Leu His Leu Ala Ala Thr Lys Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Val Gly Tyr Thr Pro Leu His Val Ala Ala Ser Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Val His Gly Tyr Thr Pro Ala Asp Leu Ala Ala Gln Ala Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 29
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 29
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Asn Lys Leu 
    290                 295                 300                 
Leu Asp Ala Ala Trp Val Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Trp Gln Gly Glu Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Thr Lys Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Val Gly Tyr Thr 
        355                 360                 365             
Pro Leu His Val Ala Ala Ser Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Val His Gly Tyr 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Gln Ala Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Trp Thr Pro Leu His Leu Ala Ala His Gln Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Arg Thr Pro Leu His Leu Ala Ala Trp Val Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Ser Gly Ala Thr Pro Leu His Pro Ala Ala Ile Tyr Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 30
<211> 817
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 30
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln 
            500                 505                 510         
Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu Ser Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala 
            660                 665                 670         
Gly Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln 
    690                 695                 700                 
His Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala 
                725                 730                 735     
Trp Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala 
        755                 760                 765             
Ala Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
    770                 775                 780                 
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
785                 790                 795                 800 
Ala Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
                805                 810                 815     
Ala 
    

<210> 31
<211> 817
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 31
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala 
            660                 665                 670         
Gly Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala 
                725                 730                 735     
Trp Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala 
        755                 760                 765             
Ala Leu Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly 
    770                 775                 780                 
Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu 
785                 790                 795                 800 
Ala Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala 
                805                 810                 815     
Ala 
    

<210> 32
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 32
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Leu Lys Leu 
    290                 295                 300                 
Leu Thr Ala Ala Lys Gln Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Tyr Arg Gly Leu Thr Pro 
                325                 330                 335     
Leu His Tyr Ala Ala Ala Ile Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Tyr Gly Ala Thr 
        355                 360                 365             
Pro Leu His Val Ala Ala Tyr Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Phe Ser Gly Ser 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Glu Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 33
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 33
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Trp Lys Leu 
    290                 295                 300                 
Leu Trp Ala Ala Gln Val Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Asp Leu Gly Trp Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Trp Val Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Phe Thr Gly Arg Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Thr Glu Gly His Leu Glu Ile Val Lys Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asp Val Gly His 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Leu Trp Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Glu 
465                 470                 475                 480 
Gly Ile Thr Pro Leu His Val Ala Ala His Gln Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
His Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 34
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 34
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Lys 
            500                 505                 510         
Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Glu Thr Gly Phe Thr Pro Leu His Val Ala Ala Glu Lys 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp His Phe Gly Phe Thr Pro Leu His Leu Val Ser Glu 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Ser Tyr Gly Trp Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Ile Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 35
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 35
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Lys 
            500                 505                 510         
Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Glu Ser Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 36
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 36
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala His Gln Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Arg Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Ser Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg 
            500                 505                 510         
Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His 
            580                 585                 590         
Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
        595                 600                 605             
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
    610                 615                 620                 
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr 
625                 630                 635                 640 
Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
                645                 650                 655     
Pro Thr Gly Ser Asp Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala 
            660                 665                 670         
Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Val Ala Ala Val 
    690                 695                 700                 
Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala 
                725                 730                 735     
Arg Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Phe Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 37
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 37
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly His Lys Leu 
    290                 295                 300                 
Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Trp Ile Gly Ile 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 38
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 38
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly His Lys Leu 
    290                 295                 300                 
Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr 
        355                 360                 365             
Pro Leu His His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Trp Ile Gly Ile 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val 
    450                 455                 460                 
Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu 
465                 470                 475                 480 
Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Arg Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala 
                725                 730                 735     
Leu Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 39
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 39
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala His Gln Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Arg Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu Ser Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Tyr Gly 
625                 630                 635                 640 
Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Glu Ser Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 40
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 40
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Ile Thr Pro 
                325                 330                 335     
Leu His Leu Ala Ala Gln His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Gln Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Leu Ala Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Leu Tyr Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Glu Thr Gly Phe Thr Pro Leu His Val Ala Ala Glu Lys 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp His Phe Gly Phe Thr Pro Leu His Leu Val Ser Glu 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Ser Tyr Gly Trp Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Ile Leu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 41
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 41
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu 
    290                 295                 300                 
Leu His Ala Ala Gln Tyr Gly Gln Asp Asp Glu Val Arg Ile Leu Leu 
305                 310                 315                 320 
Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr Pro 
                325                 330                 335     
Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly Gln 
385                 390                 395                 400 
Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Glu Asp Ile Ala Glu 
                405                 410                 415     
Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro 
            420                 425                 430         
Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu 
        435                 440                 445             
Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu Val 
    450                 455                 460                 
Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val Phe 
465                 470                 475                 480 
Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu Ile 
                485                 490                 495     
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser 
            500                 505                 510         
Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp 
    530                 535                 540                 
Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His Glu 
545                 550                 555                 560 
Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr 
                565                 570                 575     
Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
            580                 585                 590         
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
        595                 600                 605             
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
    610                 615                 620                 
Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln Gly 
625                 630                 635                 640 
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
    690                 695                 700                 
Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 42
<211> 784
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 42
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Glu Thr Gly Phe Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Glu Lys Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Phe Gly Phe Thr 
        355                 360                 365             
Pro Leu His Leu Val Ser Glu Trp Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Ser Tyr Gly Trp 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala Ile Leu Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly His Lys Leu Leu Leu Ala Ala Gln Ala Gly Gln Asp Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp 
    690                 695                 700                 
Gln Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala 
                725                 730                 735     
Leu Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala 
            740                 745                 750         
Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala 
        755                 760                 765             
Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    770                 775                 780                 



<210> 43
<211> 703
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 43
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Gly Gly 
            660                 665                 670         
Gly Ser Gly Gly Gly Ser His His His His His His His His His His 
        675                 680                 685             
Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
    690                 695                 700             

<210> 44
<211> 1209
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 44
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         
Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             
Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 
Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 
Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     
Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         
Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             
Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 
Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 
Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     
Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         
Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             
Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 
Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 
Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     
Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         
Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             
Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 
Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 
Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     
Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         
Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
        995                 1000                1005            
Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg 
    1010                1015                1020                
Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser 
1025                1030                1035                1040
Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 
                1045                1050                1055    
Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala 
            1060                1065                1070        
His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe 
        1075                1080                1085            
Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn 
    1090                1095                1100                
Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn 
1105                1110                1115                1120
Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu 
                1125                1130                1135    
Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly 
            1140                1145                1150        
Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
        1155                1160                1165            
Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp 
    1170                1175                1180                
Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Ala His 
1185                1190                1195                1200
His His His His His His His His His 
                1205                

<210> 45
<211> 462
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 45
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 
Gly Gly Ser Gly Gly Gly Ser Pro Lys Ser Ser Asp Lys Thr His Thr 
225                 230                 235                 240 
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                245                 250                 255     
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            260                 265                 270         
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        275                 280                 285             
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    290                 295                 300                 
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
305                 310                 315                 320 
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                325                 330                 335     
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            340                 345                 350         
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        355                 360                 365             
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    370                 375                 380                 
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
385                 390                 395                 400 
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                405                 410                 415     
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            420                 425                 430         
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        435                 440                 445             
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460         

<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> His-tag

<400> 46
Met Arg Gly Ser His His His His His His 
1               5                   10  

<210> 47
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human serum albumin binding domain

<400> 47
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 48
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human serum albumin binding domain

<400> 48
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Ala Asp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 49
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Human serum albumin binding domain

<400> 49
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asp Ala 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 50
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus sequence

<220> 
<221> VARIANT
<222> 2,3,5,12,13,14,16,17,18,21,25,26,33
<223> x" denotes any amino acid

<400> 50
Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Xaa Xaa Xaa Gly Xaa 
1               5                   10                  15      
Xaa Xaa Leu Val Xaa Val Leu Leu Xaa Xaa Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Xaa 
    

<210> 51
<211> 33
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus sequence

<220> 
<221> VARIANT
<222> 2,3,5,13,14,26,33
<223> x" denotes any amino acid
      x" in position 26 is selected from the group consisting of
      asparagine, histidine, or tyrosine

<400> 51
Asp Xaa Xaa Gly Xaa Thr Pro Leu His Leu Ala Ala Xaa Xaa Gly His 
1               5                   10                  15      
Leu Glu Ile Val Glu Val Leu Leu Lys Xaa Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Xaa 
    

<210> 52
<211> 24
<212> PRT
<213> Artificial Sequence


<220> 
<223> PT-rich linker

<400> 52
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro Thr Gly Ser 
            20                  

<210> 53
<211> 22
<212> PRT
<213> Artificial Sequence


<220> 
<223> PT-rich linker

<400> 53
Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr 
1               5                   10                  15      
Pro Thr Pro Thr Pro Thr 
            20          

<210> 54
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Consensus GS linker

<220> 
<221> VARIANT
<222> 1..5
<223> [Gly-Gly-Gly-Gly-Ser]n, wherein n is 1, 2, 3, 4, 5, or 6

<400> 54
Gly Gly Gly Gly Ser 
1               5   

<210> 55
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 55
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          



<210> 56
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 56
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          



<210> 57
<211> 32
<212> PRT
<213> Artificial Sequence


<220> 
<223> N-cap

<400> 57
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Ala Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          



<210> 58
<211> 28
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-cap

<400> 58
Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly 
1               5                   10                  15      
His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            20                  25              

<210> 59
<211> 977
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 59
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      
His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  
Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 
Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 
Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         
Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             
Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 
Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 
Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     
Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         
Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             
Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 
Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 
Pro Val Ser Gly Gly Gly Ser Gly Gly Gly Ser Pro Lys Ser Ser Asp 
                725                 730                 735     
Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly 
            740                 745                 750         
Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
        755                 760                 765             
Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
    770                 775                 780                 
Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
785                 790                 795                 800 
Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
                805                 810                 815     
Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
            820                 825                 830         
Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
        835                 840                 845             
Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
    850                 855                 860                 
Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
865                 870                 875                 880 
Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
                885                 890                 895     
Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
            900                 905                 910         
Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
        915                 920                 925             
Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
    930                 935                 940                 
Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
945                 950                 955                 960 
Gly Lys Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His 
                965                 970                 975     
Glu 
    

<210> 60
<211> 756
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 60
Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe Asn 
1               5                   10                  15      
His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp Asn 
            20                  25                  30          
Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn Ala 
        35                  40                  45              
Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala Gln 
    50                  55                  60                  
Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln Leu 
65                  70                  75                  80  
Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys Ser 
                85                  90                  95      
Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser Thr 
            100                 105                 110         
Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu Glu 
        115                 120                 125             
Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu Arg 
    130                 135                 140                 
Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu Arg 
145                 150                 155                 160 
Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg Ala 
                165                 170                 175     
Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu Val 
            180                 185                 190         
Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu Asp 
        195                 200                 205             
Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu His 
    210                 215                 220                 
Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile Ser 
225                 230                 235                 240 
Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly Arg 
                245                 250                 255     
Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys Pro 
            260                 265                 270         
Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala Gln 
        275                 280                 285             
Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu Pro 
    290                 295                 300                 
Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro Gly 
305                 310                 315                 320 
Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly Lys 
                325                 330                 335     
Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp Phe 
            340                 345                 350         
Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala Tyr 
        355                 360                 365             
Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe His 
    370                 375                 380                 
Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys His 
385                 390                 395                 400 
Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn Glu 
                405                 410                 415     
Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly Thr 
            420                 425                 430         
Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe Lys 
        435                 440                 445             
Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met Lys 
    450                 455                 460                 
Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr Tyr 
465                 470                 475                 480 
Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe Ile 
                485                 490                 495     
Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala Leu 
            500                 505                 510         
Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile Ser 
        515                 520                 525             
Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu Gly 
    530                 535                 540                 
Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala Lys 
545                 550                 555                 560 
Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe Thr 
                565                 570                 575     
Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr Asp 
            580                 585                 590         
Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu Lys 
        595                 600                 605             
Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met Tyr 
    610                 615                 620                 
Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu Lys 
625                 630                 635                 640 
Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val Ala 
                645                 650                 655     
Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro Lys 
            660                 665                 670         
Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile Arg 
        675                 680                 685             
Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn Ser 
    690                 695                 700                 
Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln Pro 
705                 710                 715                 720 
Pro Val Ser Gly Gly Gly Ser Gly Gly Gly Ser His His His His His 
                725                 730                 735     
His His His His His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
            740                 745                 750         
Glu Trp His Glu 
        755     

<210> 61
<211> 1209
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 61
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
            660                 665                 670         
Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             
Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 
Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 
Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     
Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         
Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             
Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 
Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 
Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     
Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         
Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             
Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 
Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 
Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     
Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         
Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             
Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 
Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 
Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     
Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         
Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala Asn 
        995                 1000                1005            
Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys Arg 
    1010                1015                1020                
Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln Ser 
1025                1030                1035                1040
Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala Gln 
                1045                1050                1055    
Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys Ala 
            1060                1065                1070        
His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp Phe 
        1075                1080                1085            
Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp Asn 
    1090                1095                1100                
Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn Asn 
1105                1110                1115                1120
Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu Glu 
                1125                1130                1135    
Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu Gly 
            1140                1145                1150        
Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu Ile 
        1155                1160                1165            
Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile Asp 
    1170                1175                1180                
Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro Ala His 
1185                1190                1195                1200
His His His His His His His His His 
                1205                

<210> 62
<211> 256
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 62
Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      
Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          
Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              
Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  
Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  
Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      
Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         
Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             
Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 
Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 
Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     
Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         
Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             
Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Gly 
    210                 215                 220                 
Gly Gly Ser Gly Gly Gly Ser His His His His His His His His His 
225                 230                 235                 240 
His Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
                245                 250                 255     



<210> 63
<211> 908
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 63
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ala Asp 
            660                 665                 670         
Asp Asp Asp Lys Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro 
        675                 680                 685             
Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
    690                 695                 700                 
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
705                 710                 715                 720 
Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
                725                 730                 735     
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
            740                 745                 750         
Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
        755                 760                 765             
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
    770                 775                 780                 
Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
785                 790                 795                 800 
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
                805                 810                 815     
Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
            820                 825                 830         
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
        835                 840                 845             
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
    850                 855                 860                 
Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
865                 870                 875                 880 
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
                885                 890                 895     
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            900                 905             

<210> 64
<211> 681
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 64
Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      
Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          
Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              
Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  
Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  
Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      
Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         
Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             
Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 
Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 
Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     
Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         
Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             
Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 
Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 
Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     
Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         
Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             
Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 
Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 
Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     
Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         
Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             
Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 
Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 
Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     
Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         
Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             
Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 
Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 
Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     
Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         
Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             
Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 
Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 
Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     
Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         
Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             
Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 
Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 
Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     
Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ala His 
            660                 665                 670         
His His His His His His His His His 
        675                 680     

<210> 65
<211> 730
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 65
Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      
Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          
Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              
Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  
Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  
Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      
Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         
Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             
Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 
Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 
Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     
Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         
Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             
Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 
Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 
Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     
Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         
Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             
Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 
Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 
Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
                325                 330                 335     
Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         
Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             
Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
    370                 375                 380                 
Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 
Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     
Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
            420                 425                 430         
Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
        435                 440                 445             
Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
    450                 455                 460                 
Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
465                 470                 475                 480 
Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
                485                 490                 495     
Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys 
            500                 505                 510         
Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
        515                 520                 525             
Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
    530                 535                 540                 
Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
545                 550                 555                 560 
Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
                565                 570                 575     
Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
            580                 585                 590         
Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
        595                 600                 605             
Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
    610                 615                 620                 
Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
625                 630                 635                 640 
Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
                645                 650                 655     
Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Asp Pro Asp Tyr 
            660                 665                 670         
Lys Asp Asp Asp Asp Lys Ala Gly Pro Gly Trp Ser His Pro Gln Phe 
        675                 680                 685             
Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Ser 
    690                 695                 700                 
His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
705                 710                 715                 720 
Gly Ser Trp Ser His Pro Gln Phe Glu Lys 
                725                 730 

<210> 66
<211> 227
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 66
Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala 
1               5                   10                  15      
Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp 
            20                  25                  30          
Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr 
        35                  40                  45              
Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr 
    50                  55                  60                  
Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro 
65                  70                  75                  80  
Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp 
                85                  90                  95      
Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys 
            100                 105                 110         
Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn 
        115                 120                 125             
Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly 
    130                 135                 140                 
Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu 
145                 150                 155                 160 
Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr 
                165                 170                 175     
Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val 
            180                 185                 190         
Cys Gly Pro Gly Gly Gly Ser Trp Ser His Pro Gln Phe Glu Lys Gly 
        195                 200                 205             
Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Ser His Pro Gln 
    210                 215                 220                 
Phe Glu Lys 
225         

<210> 67
<211> 539
<212> PRT
<213> Artificial Sequence


<220> 
<223> Target domain of spike protein

<400> 67
Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
1               5                   10                  15      
Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            20                  25                  30          
Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        35                  40                  45              
Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    50                  55                  60                  
Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
65                  70                  75                  80  
Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                85                  90                  95      
Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            100                 105                 110         
Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        115                 120                 125             
Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    130                 135                 140                 
Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
145                 150                 155                 160 
Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                165                 170                 175     
Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            180                 185                 190         
Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        195                 200                 205             
Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    210                 215                 220                 
Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
225                 230                 235                 240 
Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                245                 250                 255     
Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            260                 265                 270         
Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        275                 280                 285             
Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala 
    290                 295                 300                 
Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
305                 310                 315                 320 
Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                325                 330                 335     
Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            340                 345                 350         
Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        355                 360                 365             
Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    370                 375                 380                 
Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
385                 390                 395                 400 
Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                405                 410                 415     
Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            420                 425                 430         
Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        435                 440                 445             
Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    450                 455                 460                 
Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
465                 470                 475                 480 
Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                485                 490                 495     
Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            500                 505                 510         
Ile Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln Tyr Ile Lys Trp Pro 
        515                 520                 525             
Ala His His His His His His His His His His 
    530                 535                 

<210> 68
<211> 521
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 68
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Ile Thr Pro Leu His Leu Ala Ala Gln His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Gln 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Leu Ala Gly Ala Thr Pro Leu His Val Ala Ala Leu 
            100                 105                 110         
Tyr Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val 
    210                 215                 220                 
Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu 
        275                 280                 285             
His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu Val Leu Leu 
    290                 295                 300                 
Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro 
305                 310                 315                 320 
Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu 
                325                 330                 335     
Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro 
            340                 345                 350         
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys 
        355                 360                 365             
Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Glu Gly Ile 
385                 390                 395                 400 
Thr Pro Leu His Val Ala Ala His Gln Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly 
            420                 425                 430         
Arg Thr Pro Leu His Leu Ala Ala Trp Arg Gly His Leu Glu Ile Val 
        435                 440                 445             
Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp His Ala 
    450                 455                 460                 
Gly Ala Thr Pro Leu His Ala Ala Ala Leu Ser Gly His Leu Glu Ile 
465                 470                 475                 480 
Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Lys 
                485                 490                 495     
Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp 
            500                 505                 510         
Ile Ala Glu Val Leu Gln Lys Ala Ala 
        515                 520     

<210> 69
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 69
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Gln Glu Gly Ile Thr Pro Leu His Val Ala Ala His Gln Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Arg 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp His Ala Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly His Lys Leu Leu Leu Ala 
            180                 185                 190         
Ala Gln Ala Gly Gln Asp Asp Glu Val Arg Ile Leu Leu Ala Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Val 
    210                 215                 220                 
Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His 
                245                 250                 255     
His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Gln Asp Trp Ile Gly Ile Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Phe Glu Gly His Glu Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys 
                325                 330                 335     
Leu Leu His Ala Ala Gln Tyr Gly Gln Asp Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Ala Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr 
        355                 360                 365             
Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly 
            420                 425                 430         
Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Glu Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala 
    450                 455 

<210> 70
<211> 477
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 70
ggcagcgatt tgggtaaaaa gctgctgcag gccgcgagag cgggccagtt ggacgaggtg      60

cgtgagctgt tgaaagcggg tgcagacgtt aatgctaaag accgcgaggg tatcactccg     120

ttgcatctgg cggcacagca cggtcatctt gagatcgtag aagtcttgtt gaaagctggt     180

gctgacgtca atgccaagga tgtttggggt cgtactccac tgcatctcgc ggcgtggcag     240

ggtcaccttg agattgtcga ggttttgctg aaagcgggcg ccgacgtcaa tgcgaaagat     300

ctggcaggcg cgacccctct gcatgttgcg gcgctgtacg gtcacctgga aatcgttgaa     360

gtcctcttga aggcgggtgc ggatgtaaac gcgcaggaca agagcggtaa aacgccggcc     420

gatctggcag cacgcgccgg tcaccaagat atcgcagaag tgctgcaaaa ggctgcg        477


<210> 71
<211> 477
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 71
ggtagcgacc tgggcaagaa actgctgcaa gccgcacgtg ccggtcagct ggacgaagtg      60

cgtgagttgt tgaaggctgg cgctgacgtg aacgcaaaag accgtgaggg taagacgccg     120

ttacacgtgg cagcgcaaga aggccacctg gagattgttg aagtgctgct caaagctggc     180

gcagacgtca acgctaaaga tgtgtggggt cgcactccgc tgcatctggc cgcgtggatt     240

ggtcatttgg aaattgtgga agttctgctc aaggccggcg ctgatgtcaa cgccaaagat     300

gtgagcggtg cgaccccgct gcacgcagcg gcgctgcacg gtcacttgga aatcgtggag     360

gttctgttga acgccggtgc tgatgttaac gcgcaagata aatcgggtaa gactccggcg     420

gatctggcgg ctcgtgcggg tcaccaggat attgccgaag ttttgcagaa agccgct        477


<210> 72
<211> 477
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 72
ggtagcgact tgggtaagaa actgttgcag gcagcgcgcg cgggtcaact ggacgaggtt      60

cgtgagcttt tgaaagccgg tgcggacgtt aacgcgaagg atcaagaagg cattacccca     120

ctgcacgtgg cggcacatca gggtcatctg gagatcgttg aggttctgct gaaggccgga     180

gcggatgtca acgcgaaaga cgtttggggc cgtaccccat tgcacctggc ggcgtggcgc     240

ggtcacctcg aaatcgtcga agtgttactg aaagctgggg cagatgtgaa cgccaaggac     300

cacgcgggtg cgacgccgct gcatgcggca gcgctgagcg gccatctgga aattgtcgaa     360

gtcctgctga aagccggcgc agatgttaat gcccaggata aatccggtaa gaccccggca     420

gacctggcag cgcgtgcggg ccaccaagac attgccgagg ttctgcaaaa agccgcg        477


<210> 73
<211> 1563
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 73
ggcagcgatt tgggtaaaaa gctgctgcag gccgcgagag cgggccagtt ggacgaggtg      60

cgtgagctgt tgaaagcggg tgcagacgtt aatgctaaag accgcgaggg tatcactccg     120

ttgcatctgg cggcacagca cggtcatctt gagatcgtag aagtcttgtt gaaagctggt     180

gctgacgtca atgccaagga tgtttggggt cgtactccac tgcatctcgc ggcgtggcag     240

ggtcaccttg agattgtcga ggttttgctg aaagcgggcg ccgacgtcaa tgcgaaagat     300

ctggcaggcg cgacccctct gcatgttgcg gcgctgtacg gtcacctgga aatcgttgaa     360

gtcctcttga aggcgggtgc ggatgtaaac gcgcaggaca agagcggtaa aacgccggcc     420

gatctggcag cacgcgccgg tcaccaagat atcgcagaag tgctgcaaaa ggctgcgggt     480

agcccaaccc caacgccgac cactcctacc cctaccccaa ccaccccaac tccaactccg     540

actggtagcg acctgggcaa gaaactgctg caagccgcac gtgccggtca gctggacgaa     600

gtgcgtgagt tgttgaaggc tggcgctgac gtgaacgcaa aagaccgtga gggtaagacg     660

ccgttacacg tggcagcgca agaaggccac ctggagattg ttgaagtgct gctcaaagct     720

ggcgcagacg tcaacgctaa agatgtgtgg ggtcgcactc cgctgcatct ggccgcgtgg     780

attggtcatt tggaaattgt ggaagttctg ctcaaggccg gcgctgatgt caacgccaaa     840

gatgtgagcg gtgcgacccc gctgcacgca gcggcgctgc acggtcactt ggaaatcgtg     900

gaggttctgt tgaacgccgg tgctgatgtt aacgcgcaag ataaatcggg taagactccg     960

gcggatctgg cggctcgtgc gggtcaccag gatattgccg aagttttgca gaaagccgct    1020

ggttctccta cgccgacccc gacgacgccg actccaaccc cgaccacgcc gacgcctacc    1080

ccgaccggta gcgacttggg taagaaactg ttgcaggcag cgcgcgcggg tcaactggac    1140

gaggttcgtg agcttttgaa agccggtgcg gacgttaacg cgaaggatca agaaggcatt    1200

accccactgc acgtggcggc acatcagggt catctggaga tcgttgaggt tctgctgaag    1260

gccggagcgg atgtcaacgc gaaagacgtt tggggccgta ccccattgca cctggcggcg    1320

tggcgcggtc acctcgaaat cgtcgaagtg ttactgaaag ctggggcaga tgtgaacgcc    1380

aaggaccacg cgggtgcgac gccgctgcat gcggcagcgc tgagcggcca tctggaaatt    1440

gtcgaagtcc tgctgaaagc cggcgcagat gttaatgccc aggataaatc cggtaagacc    1500

ccggcagacc tggcagcgcg tgcgggccac caagacattg ccgaggttct gcaaaaagcc    1560

gcg                                                                  1563


<210> 74
<211> 2451
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 74
ggatccgatc tgggcaaaaa gttgctggaa gcggcacgtg caggccagga cgatgaagtt      60

cgcgagctgt taaaagcagg cgcagatgtt aatgcgaagg actatttcag ccacacgccg     120

ttgcatttgg cggcacgtaa cggccacctg aaaatcgtgg aagtgctgtt aaaggctggt     180

gccgatgtga atgccaaaga ttttgcgggt aaaaccccgt tacacttggc ggcgaacgag     240

ggtcatttag agatcgtcga ggtcctgctt aaggctggcg cggacgtaaa tgcgcaagac     300

atcttcggca aaaccccggc tgacattgcg gcggatgcgg gccacgaaga tatcgccgaa     360

gtgttgcaaa aggcagcggg cagcccgacc ccaaccccta cgaccccgac tcctacgcct     420

acgactccga ctccgacccc tacgggtagc gatctgggta agaagctgct ggaagccgca     480

cgcgcaggcc aagacgacga agtccgtgag ctcctgaagg caggcgccga tgtcaatgca     540

aaagactact tttctcatac gccactgcac ctggcagccc gtaacggtca tctgaagatt     600

gtagaagtgt tgctgaaggc gggcgcagat gttaatgcaa aggactttgc gggcaagacc     660

ccgttgcacc ttgcggcgaa tgagggtcac ttagagattg tggaggtcct gttgaaggcc     720

ggtgccgacg tgaatgcaca agacattttc ggcaagacgc cggcagacat cgcagcggac     780

gcgggtcacg aggacatcgc tgaagttctg cagaaagctg cgggttcccc gacgccaacg     840

cctaccacgc ctacgccaac tcctaccacc ccgaccccga cgccgaccgg cagcgatttg     900

ggtaaaaagc tgctgcaggc cgcgagagcg ggccagttgg acgaggtgcg tgagctgttg     960

aaagcgggtg cagacgttaa tgctaaagac cgcgagggta tcactccgtt gcatctggcg    1020

gcacagcacg gtcatcttga gatcgtagaa gtcttgttga aagctggtgc tgacgtcaat    1080

gccaaggatg tttggggtcg tactccactg catctcgcgg cgtggcaggg tcaccttgag    1140

attgtcgagg ttttgctgaa agcgggcgcc gacgtcaatg cgaaagatct ggcaggcgcg    1200

acccctctgc atgttgcggc gctgtacggt cacctggaaa tcgttgaagt cctcttgaag    1260

gcgggtgcgg atgtaaacgc gcaggacaag agcggtaaaa cgccggccga tctggcagca    1320

cgcgccggtc accaagatat cgcagaagtg ctgcaaaagg ctgcgggtag cccaacccca    1380

acgccgacca ctcctacccc taccccaacc accccaactc caactccgac tggtagcgac    1440

ctgggcaaga aactgctgca agccgcacgt gccggtcagc tggacgaagt gcgtgagttg    1500

ttgaaggctg gcgctgacgt gaacgcaaaa gaccgtgagg gtaagacgcc gttacacgtg    1560

gcagcgcaag aaggccacct ggagattgtt gaagtgctgc tcaaagctgg cgcagacgtc    1620

aacgctaaag atgtgtgggg tcgcactccg ctgcatctgg ccgcgtggat tggtcatttg    1680

gaaattgtgg aagttctgct caaggccggc gctgatgtca acgccaaaga tgtgagcggt    1740

gcgaccccgc tgcacgcagc ggcgctgcac ggtcacttgg aaatcgtgga ggttctgttg    1800

aacgccggtg ctgatgttaa cgcgcaagat aaatcgggta agactccggc ggatctggcg    1860

gctcgtgcgg gtcaccagga tattgccgaa gttttgcaga aagccgctgg ttctcctacg    1920

ccgaccccga cgacgccgac tccaaccccg accacgccga cgcctacccc gaccggtagc    1980

gacttgggta agaaactgtt gcaggcagcg cgcgcgggtc aactggacga ggttcgtgag    2040

cttttgaaag ccggtgcgga cgttaacgcg aaggatcaag aaggcattac cccactgcac    2100

gtggcggcac atcagggtca tctggagatc gttgaggttc tgctgaaggc cggagcggat    2160

gtcaacgcga aagacgtttg gggccgtacc ccattgcacc tggcggcgtg gcgcggtcac    2220

ctcgaaatcg tcgaagtgtt actgaaagct ggggcagatg tgaacgccaa ggaccacgcg    2280

ggtgcgacgc cgctgcatgc ggcagcgctg agcggccatc tggaaattgt cgaagtcctg    2340

ctgaaagccg gcgcagatgt taatgcccag gataaatccg gtaagacccc ggcagacctg    2400

gcagcgcgtg cgggccacca agacattgcc gaggttctgc aaaaagccgc g             2451


<210> 75
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 75
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Glu Ser Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 76
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 76
Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Val Phe Gly Gln Thr Pro Leu His Val Ala Ala Val Ala Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His His Ala Ala Arg Val 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Trp Ile Gly Ile Thr Pro Ala Asp Leu Ala Ala Phe 
            100                 105                 110         
Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 77
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 77
Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Trp 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala Glu 
            100                 105                 110         
Ser Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 78
<211> 2253
<212> PRT
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 78
Gly Gly Ala Thr Cys Cys Gly Ala Cys Cys Thr Gly Gly Gly Thr Ala 
1               5                   10                  15      
Ala Ala Ala Ala Gly Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Cys 
            20                  25                  30          
Ala Gly Cys Gly Cys Gly Thr Gly Cys Cys Gly Gly Thr Cys Ala Ala 
        35                  40                  45              
Gly Ala Cys Gly Ala Cys Gly Ala Gly Gly Thr Thr Cys Gly Cys Gly 
    50                  55                  60                  
Ala Ala Thr Thr Gly Cys Thr Thr Ala Ala Ala Gly Cys Gly Gly Gly 
65                  70                  75                  80  
Thr Gly Cys Ala Gly Ala Cys Gly Thr Cys Ala Ala Cys Gly Cys Cys 
                85                  90                  95      
Ala Ala Ala Gly Ala Thr Thr Ala Thr Thr Thr Cys Thr Cys Thr Cys 
            100                 105                 110         
Ala Thr Ala Cys Cys Cys Cys Gly Thr Thr Gly Cys Ala Thr Thr Thr 
        115                 120                 125             
Ala Gly Cys Cys Gly Cys Gly Cys Gly Thr Ala Ala Thr Gly Gly Cys 
    130                 135                 140                 
Cys Ala Thr Cys Thr Gly Ala Ala Gly Ala Thr Cys Gly Thr Cys Gly 
145                 150                 155                 160 
Ala Gly Gly Thr Cys Cys Thr Cys Thr Thr Gly Ala Ala Gly Gly Cys 
                165                 170                 175     
Ala Gly Gly Cys Gly Cys Gly Gly Ala Thr Gly Thr Cys Ala Ala Thr 
            180                 185                 190         
Gly Cys Gly Ala Ala Gly Gly Ala Thr Thr Thr Thr Gly Cys Gly Gly 
        195                 200                 205             
Gly Cys Ala Ala Ala Ala Cys Gly Cys Cys Gly Cys Thr Gly Cys Ala 
    210                 215                 220                 
Cys Thr Thr Ala Gly Cys Gly Gly Cys Gly Ala Ala Cys Gly Ala Gly 
225                 230                 235                 240 
Gly Gly Thr Cys Ala Thr Thr Thr Ala Gly Ala Ala Ala Thr Cys Gly 
                245                 250                 255     
Thr Thr Gly Ala Ala Gly Thr Cys Cys Thr Gly Thr Thr Ala Ala Ala 
            260                 265                 270         
Ala Gly Cys Gly Gly Gly Cys Gly Cys Cys Gly Ala Thr Gly Thr Gly 
        275                 280                 285             
Ala Ala Thr Gly Cys Gly Cys Ala Gly Gly Ala Thr Ala Thr Thr Thr 
    290                 295                 300                 
Thr Cys Gly Gly Thr Ala Ala Ala Ala Cys Gly Cys Cys Gly Gly Cys 
305                 310                 315                 320 
Gly Gly Ala Cys Ala Thr Thr Gly Cys Gly Gly Cys Ala Gly Ala Thr 
                325                 330                 335     
Gly Cys Gly Gly Gly Thr Cys Ala Thr Gly Ala Ala Gly Ala Thr Ala 
            340                 345                 350         
Thr Cys Gly Cys Ala Gly Ala Ala Gly Thr Cys Cys Thr Gly Cys Ala 
        355                 360                 365             
Gly Ala Ala Gly Gly Cys Ala Gly Cys Ala Gly Gly Cys Ala Gly Cys 
    370                 375                 380                 
Cys Cys Thr Ala Cys Ala Cys Cys Thr Ala Cys Gly Cys Cys Gly Ala 
385                 390                 395                 400 
Cys Thr Ala Cys Gly Cys Cys Thr Ala Cys Gly Cys Cys Gly Ala Cys 
                405                 410                 415     
Thr Cys Cys Gly Ala Cys Thr Ala Cys Cys Cys Cys Gly Ala Cys Thr 
            420                 425                 430         
Cys Cys Gly Ala Cys Cys Cys Cys Gly Ala Cys Cys Gly Gly Ala Thr 
        435                 440                 445             
Cys Ala Gly Ala Cys Cys Thr Gly Gly Gly Thr Ala Ala Ala Ala Ala 
    450                 455                 460                 
Gly Cys Thr Gly Cys Thr Gly Gly Ala Gly Gly Cys Ala Gly Cys Gly 
465                 470                 475                 480 
Cys Gly Thr Gly Cys Cys Gly Gly Thr Cys Ala Ala Gly Ala Cys Gly 
                485                 490                 495     
Ala Cys Gly Ala Gly Gly Thr Thr Cys Gly Cys Gly Ala Ala Thr Thr 
            500                 505                 510         
Gly Cys Thr Thr Ala Ala Ala Gly Cys Gly Gly Gly Thr Gly Cys Ala 
        515                 520                 525             
Gly Ala Cys Gly Thr Cys Ala Ala Cys Gly Cys Cys Ala Ala Ala Gly 
    530                 535                 540                 
Ala Thr Thr Ala Thr Thr Thr Cys Thr Cys Thr Cys Ala Thr Ala Cys 
545                 550                 555                 560 
Cys Cys Cys Gly Thr Thr Gly Cys Ala Thr Thr Thr Ala Gly Cys Cys 
                565                 570                 575     
Gly Cys Gly Cys Gly Thr Ala Ala Thr Gly Gly Cys Cys Ala Thr Cys 
            580                 585                 590         
Thr Gly Ala Ala Gly Ala Thr Cys Gly Thr Cys Gly Ala Gly Gly Thr 
        595                 600                 605             
Cys Cys Thr Cys Thr Thr Gly Ala Ala Gly Gly Cys Ala Gly Gly Cys 
    610                 615                 620                 
Gly Cys Gly Gly Ala Thr Gly Thr Cys Ala Ala Thr Gly Cys Gly Ala 
625                 630                 635                 640 
Ala Gly Gly Ala Thr Thr Thr Thr Gly Cys Gly Gly Gly Cys Ala Ala 
                645                 650                 655     
Ala Ala Cys Gly Cys Cys Gly Cys Thr Gly Cys Ala Cys Thr Thr Ala 
            660                 665                 670         
Gly Cys Gly Gly Cys Gly Ala Ala Cys Gly Ala Gly Gly Gly Thr Cys 
        675                 680                 685             
Ala Thr Thr Thr Ala Gly Ala Ala Ala Thr Cys Gly Thr Thr Gly Ala 
    690                 695                 700                 
Ala Gly Thr Cys Cys Thr Gly Thr Thr Ala Ala Ala Ala Gly Cys Gly 
705                 710                 715                 720 
Gly Gly Cys Gly Cys Cys Gly Ala Thr Gly Thr Gly Ala Ala Thr Gly 
                725                 730                 735     
Cys Gly Cys Ala Gly Gly Ala Thr Ala Thr Thr Thr Thr Cys Gly Gly 
            740                 745                 750         
Thr Ala Ala Ala Ala Cys Gly Cys Cys Gly Gly Cys Gly Gly Ala Cys 
        755                 760                 765             
Ala Thr Thr Gly Cys Gly Gly Cys Ala Gly Ala Thr Gly Cys Gly Gly 
    770                 775                 780                 
Gly Thr Cys Ala Thr Gly Ala Ala Gly Ala Thr Ala Thr Cys Gly Cys 
785                 790                 795                 800 
Ala Gly Ala Ala Gly Thr Cys Cys Thr Gly Cys Ala Gly Ala Ala Gly 
                805                 810                 815     
Gly Cys Ala Gly Cys Ala Gly Gly Thr Thr Cys Cys Cys Cys Gly Ala 
            820                 825                 830         
Cys Cys Cys Cys Thr Ala Cys Gly Cys Cys Ala Ala Cys Gly Ala Cys 
        835                 840                 845             
Thr Cys Cys Gly Ala Cys Cys Cys Cys Ala Ala Cys Thr Cys Cys Ala 
    850                 855                 860                 
Ala Cys Gly Ala Cys Cys Cys Cys Thr Ala Cys Cys Cys Cys Gly Ala 
865                 870                 875                 880 
Cys Cys Cys Cys Gly Ala Cys Cys Gly Gly Ala Thr Cys Ala Gly Ala 
                885                 890                 895     
Cys Cys Thr Gly Gly Gly Thr Ala Ala Ala Ala Ala Ala Cys Thr Gly 
            900                 905                 910         
Cys Thr Gly Cys Ala Ala Gly Cys Ala Gly Cys Ala Cys Gly Thr Gly 
        915                 920                 925             
Cys Ala Gly Gly Thr Cys Ala Gly Cys Thr Gly Gly Ala Thr Gly Ala 
    930                 935                 940                 
Ala Gly Thr Thr Cys Gly Thr Gly Ala Ala Cys Thr Gly Cys Thr Gly 
945                 950                 955                 960 
Ala Ala Ala Gly Cys Ala Gly Gly Cys Gly Cys Cys Gly Ala Thr Gly 
                965                 970                 975     
Thr Thr Ala Ala Thr Gly Cys Ala Ala Ala Ala Gly Ala Thr Ala Gly 
            980                 985                 990         
Ala Gly Ala Gly Gly Gly Cys Ala Ala Gly Ala Cys Cys Cys Cys Gly 
        995                 1000                1005            
Cys Thr Gly Cys Ala Thr Gly Thr Gly Gly Cys Thr Gly Cys Thr Cys 
    1010                1015                1020                
Ala Ala Gly Ala Gly Gly Gly Thr Cys Ala Cys Cys Thr Gly Gly Ala 
1025                1030                1035                1040
Ala Ala Thr Thr Gly Thr Thr Gly Ala Ala Gly Thr Thr Cys Thr Gly 
                1045                1050                1055    
Cys Thr Gly Ala Ala Ala Gly Cys Cys Gly Gly Thr Gly Cys Ala Gly 
            1060                1065                1070        
Ala Thr Gly Thr Thr Ala Ala Thr Gly Cys Ala Ala Ala Ala Gly Ala 
        1075                1080                1085            
Thr Gly Thr Gly Thr Gly Gly Gly Gly Cys Ala Gly Ala Ala Cys Cys 
    1090                1095                1100                
Cys Cys Gly Cys Thr Gly Cys Ala Thr Cys Thr Gly Gly Cys Thr Gly 
1105                1110                1115                1120
Cys Thr Thr Gly Gly Ala Thr Cys Gly Gly Thr Cys Ala Cys Cys Thr 
                1125                1130                1135    
Gly Gly Ala Ala Ala Thr Thr Gly Thr Thr Gly Ala Ala Gly Thr Thr 
            1140                1145                1150        
Cys Thr Gly Cys Thr Gly Ala Ala Ala Gly Cys Cys Gly Gly Thr Gly 
        1155                1160                1165            
Cys Ala Gly Ala Thr Gly Thr Thr Ala Ala Thr Gly Cys Ala Ala Ala 
    1170                1175                1180                
Ala Gly Ala Thr Gly Thr Gly Thr Cys Thr Gly Gly Cys Gly Cys Thr 
1185                1190                1195                1200
Ala Cys Cys Cys Cys Gly Cys Thr Gly Cys Ala Thr Gly Cys Gly Gly 
                1205                1210                1215    
Cys Thr Gly Cys Thr Cys Thr Gly Cys Ala Cys Gly Gly Thr Cys Ala 
            1220                1225                1230        
Cys Cys Thr Gly Gly Ala Ala Ala Thr Thr Gly Thr Thr Gly Ala Ala 
        1235                1240                1245            
Gly Thr Thr Cys Thr Gly Cys Thr Gly Ala Ala Cys Gly Cys Cys Gly 
    1250                1255                1260                
Gly Thr Gly Cys Ala Gly Ala Thr Gly Thr Thr Ala Ala Cys Gly Cys 
1265                1270                1275                1280
Ala Cys Ala Gly Gly Ala Thr Ala Ala Ala Ala Gly Cys Gly Gly Thr 
                1285                1290                1295    
Ala Ala Ala Ala Cys Cys Cys Cys Thr Gly Cys Cys Gly Ala Thr Cys 
            1300                1305                1310        
Thr Gly Gly Cys Ala Gly Cys Thr Cys Gly Cys Gly Cys Cys Gly Gly 
        1315                1320                1325            
Thr Cys Ala Thr Cys Ala Gly Gly Ala Thr Ala Thr Thr Gly Cys Thr 
    1330                1335                1340                
Gly Ala Ala Gly Thr Gly Cys Thr Gly Cys Ala Gly Ala Ala Gly Gly 
1345                1350                1355                1360
Cys Ala Gly Cys Ala Gly Gly Cys Ala Gly Cys Cys Cys Cys Ala Cys 
                1365                1370                1375    
Gly Cys Cys Ala Ala Cys Thr Cys Cys Thr Ala Cys Ala Ala Cys Cys 
            1380                1385                1390        
Cys Cys Cys Ala Cys Ala Cys Cys Thr Ala Cys Ala Cys Cys Gly Ala 
        1395                1400                1405            
Cys Gly Ala Cys Gly Cys Cys Gly Ala Cys Ala Cys Cys Gly Ala Cys 
    1410                1415                1420                
Thr Cys Cys Ala Ala Cys Cys Gly Gly Ala Thr Cys Ala Gly Ala Cys 
1425                1430                1435                1440
Cys Thr Gly Gly Gly Thr Ala Ala Ala Ala Ala Ala Thr Thr Gly Thr 
                1445                1450                1455    
Thr Ala Thr Thr Gly Gly Cys Cys Gly Cys Thr Cys Gly Cys Gly Cys 
            1460                1465                1470        
Gly Gly Gly Cys Cys Ala Gly Cys Thr Gly Gly Ala Cys Gly Ala Gly 
        1475                1480                1485            
Gly Thr Ala Cys Gly Thr Ala Thr Cys Thr Thr Ala Thr Thr Gly Ala 
    1490                1495                1500                
Ala Gly Gly Cys Thr Gly Gly Gly Gly Cys Ala Gly Ala Cys Gly Thr 
1505                1510                1515                1520
Cys Ala Ala Thr Gly Cys Gly Ala Ala Gly Gly Ala Cys Gly Thr Thr 
                1525                1530                1535    
Thr Thr Thr Gly Gly Ala Cys Ala Gly Ala Cys Thr Cys Cys Thr Cys 
            1540                1545                1550        
Thr Thr Cys Ala Thr Gly Thr Gly Gly Cys Cys Gly Cys Cys Gly Thr 
        1555                1560                1565            
Gly Gly Cys Cys Gly Gly Thr Cys Ala Thr Cys Thr Gly Gly Ala Gly 
    1570                1575                1580                
Ala Thr Thr Gly Thr Cys Gly Ala Ala Gly Thr Ala Thr Thr Ala Thr 
1585                1590                1595                1600
Thr Ala Ala Ala Gly Gly Cys Thr Gly Gly Thr Gly Cys Ala Gly Ala 
                1605                1610                1615    
Thr Gly Thr Ala Ala Ala Thr Gly Cys Thr Ala Ala Ala Gly Ala Thr 
            1620                1625                1630        
Thr Cys Thr Ala Thr Cys Gly Gly Ala Thr Ala Cys Ala Cys Ala Cys 
        1635                1640                1645            
Cys Gly Thr Thr Gly Cys Ala Thr Cys Ala Thr Gly Cys Ala Gly Cys 
    1650                1655                1660                
Thr Cys Gly Cys Gly Thr Thr Gly Gly Ala Cys Ala Thr Thr Thr Ala 
1665                1670                1675                1680
Gly Ala Gly Ala Thr Cys Gly Thr Cys Gly Ala Gly Gly Thr Cys Thr 
                1685                1690                1695    
Thr Gly Cys Thr Gly Ala Ala Ala Gly Cys Ala Gly Gly Thr Gly Cys 
            1700                1705                1710        
Cys Gly Ala Cys Gly Thr Thr Ala Ala Thr Gly Cys Cys Ala Ala Gly 
        1715                1720                1725            
Gly Ala Thr Thr Gly Gly Ala Thr Cys Gly Gly Gly Ala Thr Cys Ala 
    1730                1735                1740                
Cys Cys Cys Cys Ala Gly Cys Gly Gly Ala Thr Cys Thr Thr Gly Cys 
1745                1750                1755                1760
Ala Gly Cys Ala Thr Thr Thr Gly Ala Gly Gly Gly Thr Cys Ala Cys 
                1765                1770                1775    
Cys Ala Gly Gly Ala Thr Ala Thr Thr Gly Cys Thr Gly Ala Ala Gly 
            1780                1785                1790        
Thr Thr Cys Thr Gly Cys Ala Gly Ala Ala Gly Gly Cys Ala Gly Cys 
        1795                1800                1805            
Ala Gly Gly Thr Thr Cys Gly Cys Cys Gly Ala Cys Cys Cys Cys Ala 
    1810                1815                1820                
Ala Cys Cys Cys Cys Thr Ala Cys Cys Ala Cys Thr Cys Cys Ala Ala 
1825                1830                1835                1840
Cys Gly Cys Cys Gly Ala Cys Gly Cys Cys Thr Ala Cys Cys Ala Cys 
                1845                1850                1855    
Thr Cys Cys Ala Ala Cys Ala Cys Cys Ala Ala Cys Ala Cys Cys Ala 
            1860                1865                1870        
Ala Cys Gly Gly Gly Ala Thr Cys Ala Gly Ala Cys Cys Thr Gly Gly 
        1875                1880                1885            
Gly Thr Cys Ala Ala Ala Ala Gly Thr Thr Gly Thr Thr Ala Cys Ala 
    1890                1895                1900                
Cys Gly Cys Gly Gly Cys Thr Cys Ala Ala Gly Cys Gly Gly Gly Ala 
1905                1910                1915                1920
Cys Ala Ala Thr Thr Ala Gly Ala Cys Gly Ala Gly Gly Thr Cys Cys 
                1925                1930                1935    
Gly Thr Ala Thr Thr Cys Thr Gly Cys Thr Thr Ala Ala Ala Gly Cys 
            1940                1945                1950        
Cys Gly Gly Gly Gly Cys Thr Gly Ala Thr Gly Thr Ala Ala Ala Thr 
        1955                1960                1965            
Gly Cys Ala Ala Ala Ala Gly Ala Cys Ala Ala Ala Cys Ala Gly Gly 
    1970                1975                1980                
Gly Cys Ala Ala Cys Ala Cys Ala Cys Cys Cys Thr Thr Ala Cys Ala 
1985                1990                1995                2000
Thr Ala Thr Cys Gly Cys Gly Gly Cys Ala Thr Thr Cys Cys Ala Thr 
                2005                2010                2015    
Gly Gly Ala Cys Ala Thr Cys Thr Gly Gly Ala Gly Ala Thr Thr Gly 
            2020                2025                2030        
Thr Gly Gly Ala Ala Gly Thr Ala Cys Thr Gly Cys Thr Gly Ala Ala 
        2035                2040                2045            
Ala Gly Cys Cys Gly Gly Gly Gly Cys Ala Gly Ala Thr Gly Thr Cys 
    2050                2055                2060                
Ala Ala Cys Gly Cys Thr Ala Ala Ala Gly Ala Cys Cys Ala Ala Thr 
2065                2070                2075                2080
Gly Gly Gly Gly Ala Thr Thr Gly Ala Cys Cys Cys Cys Cys Cys Thr 
                2085                2090                2095    
Thr Cys Ala Thr Thr Thr Gly Gly Cys Cys Gly Cys Thr Gly Cys Cys 
            2100                2105                2110        
Thr Gly Gly Gly Gly Cys Cys Ala Thr Thr Thr Gly Gly Ala Gly Ala 
        2115                2120                2125            
Thr Thr Gly Thr Ala Gly Ala Gly Gly Thr Ala Cys Thr Thr Cys Thr 
    2130                2135                2140                
Gly Ala Ala Gly Gly Cys Gly Gly Gly Gly Gly Cys Thr Gly Ala Thr 
2145                2150                2155                2160
Gly Thr Thr Ala Ala Thr Gly Cys Cys Cys Ala Gly Gly Ala Thr Ala 
                2165                2170                2175    
Ala Cys Thr Ala Thr Gly Gly Gly Cys Ala Ala Ala Cys Thr Cys Cys 
            2180                2185                2190        
Thr Gly Cys Gly Gly Ala Thr Cys Thr Gly Gly Cys Gly Gly Cys Thr 
        2195                2200                2205            
Gly Ala Ala Thr Cys Thr Gly Gly Gly Cys Ala Cys Cys Ala Ala Gly 
    2210                2215                2220                
Ala Thr Ala Thr Thr Gly Cys Thr Gly Ala Ala Gly Thr Thr Cys Thr 
2225                2230                2235                2240
Gly Cys Ala Gly Ala Ala Gly Gly Cys Gly Gly Cys Ala 
                2245                2250            

<210> 79
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 79
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Val 
    210                 215                 220                 
Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Ser Ile Gly Tyr Thr Pro Leu His 
                245                 250                 255     
His Ala Ala Arg Val Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Lys Asp Trp Ile Gly Ile Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Phe Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys 
                325                 330                 335     
Leu Leu His Ala Ala Gln Ala Gly Gln Leu Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr 
        355                 360                 365             
Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly 
            420                 425                 430         
Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala 
    450                 455 

<210> 80
<211> 477
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 80
ggatcagacc tgggtaaaaa actgctgcaa gcagcacgtg caggtcagct ggatgaagtt      60

cgtgaactgc tgaaagcagg cgccgatgtt aatgcaaaag atagagaggg caagaccccg     120

ctgcatgtgg ctgctcaaga gggtcacctg gaaattgttg aagttctgct gaaagccggt     180

gcagatgtta atgcaaaaga tgtgtggggc agaaccccgc tgcatctggc tgcttggatc     240

ggtcacctgg aaattgttga agttctgctg aaagccggtg cagatgttaa tgcaaaagat     300

gtgtctggcg ctaccccgct gcatgcggct gctctgcacg gtcacctgga aattgttgaa     360

gttctgctga acgccggtgc agatgttaac gcacaggata aaagcggtaa aacccctgcc     420

gatctggcag ctcgcgccgg tcatcaggat attgctgaag tgctgcagaa ggcagca        477


<210> 81
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 81
ggatcagacc tgggtaaaaa attgttattg gccgctcgcg cgggccagct ggacgaggta      60

cgtatcttat tgaaggctgg ggcagacgtc aatgcgaagg acgtttttgg acagactcct     120

cttcatgtgg ccgccgtggc cggtcatctg gagattgtcg aagtattatt aaaggctggt     180

gcagatgtaa atgctaaaga ttctatcgga tacacaccgt tgcatcatgc agctcgcgtt     240

ggacatttag agatcgtcga ggtcttgctg aaagcaggtg ccgacgttaa tgccaaggat     300

tggatcggga tcaccccagc ggatcttgca gcatttgagg gtcaccagga tattgctgaa     360

gttctgcaga aggcagca                                                   378


<210> 82
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 82
ggatcagacc tgggtcaaaa gttgttacac gcggctcaag cgggacaatt agacgaggtc      60

cgtattctgc ttaaagccgg ggctgatgta aatgcaaaag acaaacaggg caacacaccc     120

ttacatatcg cggcattcca tggacatctg gagattgtgg aagtactgct gaaagccggg     180

gcagatgtca acgctaaaga ccaatgggga ttgacccccc ttcatttggc cgctgcctgg     240

ggccatttgg agattgtaga ggtacttctg aaggcggggg ctgatgttaa tgcccaggat     300

aactatgggc aaactcctgc ggatctggcg gctgaatctg ggcaccaaga tattgctgaa     360

gttctgcaga aggcggca                                                   378


<210> 83
<211> 1365
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 83
ggatcagacc tgggtaaaaa actgctgcaa gcagcacgtg caggtcagct ggatgaagtt      60

cgtgaactgc tgaaagcagg cgccgatgtt aatgcaaaag atagagaggg caagaccccg     120

ctgcatgtgg ctgctcaaga gggtcacctg gaaattgttg aagttctgct gaaagccggt     180

gcagatgtta atgcaaaaga tgtgtggggc agaaccccgc tgcatctggc tgcttggatc     240

ggtcacctgg aaattgttga agttctgctg aaagccggtg cagatgttaa tgcaaaagat     300

gtgtctggcg ctaccccgct gcatgcggct gctctgcacg gtcacctgga aattgttgaa     360

gttctgctga acgccggtgc agatgttaac gcacaggata aaagcggtaa aacccctgcc     420

gatctggcag ctcgcgccgg tcatcaggat attgctgaag tgctgcagaa ggcagcaggc     480

agccccacgc caactcctac aacccccaca cctacaccga cgacgccgac accgactcca     540

accggatcag acctgggtaa aaaattgtta ttggccgctc gcgcgggcca gctggacgag     600

gtacgtatct tattgaaggc tggggcagac gtcaatgcga aggacgtttt tggacagact     660

cctcttcatg tggccgccgt ggccggtcat ctggagattg tcgaagtatt attaaaggct     720

ggtgcagatg taaatgctaa agattctatc ggatacacac cgttgcatca tgcagctcgc     780

gttggacatt tagagatcgt cgaggtcttg ctgaaagcag gtgccgacgt taatgccaag     840

gattggatcg ggatcacccc agcggatctt gcagcatttg agggtcacca ggatattgct     900

gaagttctgc agaaggcagc aggttcgccg accccaaccc ctaccactcc aacgccgacg     960

cctaccactc caacaccaac accaacggga tcagacctgg gtcaaaagtt gttacacgcg    1020

gctcaagcgg gacaattaga cgaggtccgt attctgctta aagccggggc tgatgtaaat    1080

gcaaaagaca aacagggcaa cacaccctta catatcgcgg cattccatgg acatctggag    1140

attgtggaag tactgctgaa agccggggca gatgtcaacg ctaaagacca atggggattg    1200

accccccttc atttggccgc tgcctggggc catttggaga ttgtagaggt acttctgaag    1260

gcgggggctg atgttaatgc ccaggataac tatgggcaaa ctcctgcgga tctggcggct    1320

gaatctgggc accaagatat tgctgaagtt ctgcagaagg cggca                    1365


<210> 84
<211> 766
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 84
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Thr Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Lys Val Gly Tyr Thr Pro Leu His Leu Ala Ala Gln Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Val Gly Val Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr 
625                 630                 635                 640 
Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Ala Gly Gln 
                645                 650                 655     
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            660                 665                 670         
Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His Gly 
        675                 680                 685             
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    690                 695                 700                 
Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala Trp 
705                 710                 715                 720 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                725                 730                 735     
Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala Glu 
            740                 745                 750         
Ser Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        755                 760                 765     

<210> 85
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Spike protein binding domain

<400> 85
Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Val Phe Gly Gln Thr Pro Leu His Thr Ala Ala Val Ala Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Lys Val Gly Tyr Thr Pro Leu His Leu Ala Ala Gln Ser 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Val Gly Val Thr Pro Ala Asp Leu Ala Ala Phe 
            100                 105                 110         
Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
        115                 120                 125     

<210> 86
<211> 2298
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 86
ggatccgacc tgggtaaaaa gctgctggag gcagcgcgtg ccggtcaaga cgacgaggtt      60

cgcgaattgc ttaaagcggg tgcagacgtc aacgccaaag attatttctc tcataccccg     120

ttgcatttag ccgcgcgtaa tggccatctg aagatcgtcg aggtcctctt gaaggcaggc     180

gcggatgtca atgcgaagga ttttgcgggc aaaacgccgc tgcacttagc ggcgaacgag     240

ggtcatttag aaatcgttga agtcctgtta aaagcgggcg ccgatgtgaa tgcgcaggat     300

attttcggta aaacgccggc ggacattgcg gcagatgcgg gtcatgaaga tatcgcagaa     360

gtcctgcaga aggcagcagg cagccctaca cctacgccga ctacgcctac gccgactccg     420

actaccccga ctccgacccc gaccggatca gacctgggta aaaagctgct ggaggcagcg     480

cgtgccggtc aagacgacga ggttcgcgaa ttgcttaaag cgggtgcaga cgtcaacgcc     540

aaagattatt tctctcatac cccgttgcat ttagccgcgc gtaatggcca tctgaagatc     600

gtcgaggtcc tcttgaaggc aggcgcggat gtcaatgcga aggattttgc gggcaaaacg     660

ccgctgcact tagcggcgaa cgagggtcat ttagaaatcg ttgaagtcct gttaaaagcg     720

ggcgccgatg tgaatgcgca ggatattttc ggtaaaacgc cggcggacat tgcggcagat     780

gcgggtcatg aagatatcgc agaagtcctg cagaaggcag caggttcccc gacccctacg     840

ccaacgactc cgaccccaac tccaacgacc cctaccccga ccccgaccgg atcagacctg     900

ggtaaaaaac tgctgcaagc agcacgtgca ggtcagctgg atgaagttcg tgaactgctg     960

aaagcaggcg ccgatgttaa tgcaaaagat agagagggca agaccccgct gcatgtggct    1020

gctcaagagg gtcacctgga aattgttgaa gttctgctga aagccggtgc agatgttaat    1080

gcaaaagatg tgtggggcag aaccccgctg catctggctg cttggatcgg tcacctggaa    1140

attgttgaag ttctgctgaa agccggtgca gatgttaatg caaaagatgt gtctggcgct    1200

accccgctgc atgcggctgc tctgcacggt cacctggaaa ttgttgaagt tctgctgaac    1260

gccggtgcag atgttaacgc acaggataaa agcggtaaaa cccctgccga tctggcagct    1320

cgcgccggtc atcaggatat tgctgaagtg ctgcagaagg cagcaggcag ccccacgcca    1380

actcctacaa cccccacacc tacaccgacg acgccgacac cgactccaac cggatcagac    1440

ctgggtaaaa agttgttact tgcagctcgc gccggccaat tggacgaagt ccgcatttta    1500

ctgaaggccg gtgcggatgt gaacgcgaaa gacgtgtttg ggcagacccc tcttcacacc    1560

gcagcagttg caggtcatct ggagatcgtg gaagtgcttt taaaagcggg tgcggacgtc    1620

aacgctaagg acaaagttgg gtacacgcca ctgcacttag ctgcacagtc aggacatctt    1680

gagattgtgg aggtcttgct gaaggcaggc gcagatgtga acgctaagga tgtcgttggg    1740

gttacgccgg cggatttggc agctttcgag ggacaccagg acattgctga agttctgcag    1800

aaggcagcag gttcgccgac cccaacccct accactccaa cgccgacgcc taccactcca    1860

acaccaacac caacgggatc accaactcca acaccgacca ccccgacccc taccccaaca    1920

ggatcagacc tgggtcaaaa gttgttacac gcggctcaag cgggacaatt agacgaggtc    1980

cgtattctgc ttaaagccgg ggctgatgta aatgcaaaag acaaacaggg caacacaccc    2040

ttacatatcg cggcattcca tggacatctg gagattgtgg aagtactgct gaaagccggg    2100

gcagatgtca acgctaaaga ccaatgggga ttgacccccc ttcatttggc cgctgcctgg    2160

ggccatttgg agattgtaga ggtacttctg aaggcggggg ctgatgttaa tgcccaggat    2220

aactatgggc aaactcctgc ggatctggcg gctgaatctg ggcaccaaga tattgctgaa    2280

gttctgcaga aggcggca                                                  2298


<210> 87
<211> 751
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 87
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Thr Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Lys Val Gly Tyr Thr Pro Leu His Leu Ala Ala Gln Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Val Gly Val Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Ala Gly 
625                 630                 635                 640 
Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
                645                 650                 655     
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
            660                 665                 670         
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
        675                 680                 685             
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
    690                 695                 700                 
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
705                 710                 715                 720 
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
                725                 730                 735     
Glu Ser Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
            740                 745                 750     

<210> 88
<211> 759
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 88
Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala Ala Arg Asn Gly 
        35                  40                  45              
His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu Ala Ala Asn Glu 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp Ile Ala Ala Asp 
            100                 105                 110         
Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser 
        115                 120                 125             
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr 
    130                 135                 140                 
Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Glu Ala Ala 
145                 150                 155                 160 
Arg Ala Gly Gln Asp Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala 
                165                 170                 175     
Asp Val Asn Ala Lys Asp Tyr Phe Ser His Thr Pro Leu His Leu Ala 
            180                 185                 190         
Ala Arg Asn Gly His Leu Lys Ile Val Glu Val Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Phe Ala Gly Lys Thr Pro Leu His Leu 
    210                 215                 220                 
Ala Ala Asn Glu Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Gln Asp Ile Phe Gly Lys Thr Pro Ala Asp 
                245                 250                 255     
Ile Ala Ala Asp Ala Gly His Glu Asp Ile Ala Glu Val Leu Gln Lys 
            260                 265                 270         
Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
        275                 280                 285             
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu 
    290                 295                 300                 
Leu Gln Ala Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Glu Leu Leu 
305                 310                 315                 320 
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Arg Glu Gly Lys Thr Pro 
                325                 330                 335     
Leu His Val Ala Ala Gln Glu Gly His Leu Glu Ile Val Glu Val Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Trp Gly Arg Thr 
        355                 360                 365             
Pro Leu His Leu Ala Ala Trp Ile Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val Ser Gly Ala 
385                 390                 395                 400 
Thr Pro Leu His Ala Ala Ala Leu His Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Asn Ala Gly Ala Asp Val Asn Ala Gln Asp Lys Ser Gly 
            420                 425                 430         
Lys Thr Pro Ala Asp Leu Ala Ala Arg Ala Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr 
    450                 455                 460                 
Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp 
465                 470                 475                 480 
Leu Gly Lys Lys Leu Leu Leu Ala Ala Arg Ala Gly Gln Leu Asp Glu 
                485                 490                 495     
Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Val 
            500                 505                 510         
Phe Gly Gln Thr Pro Leu His Thr Ala Ala Val Ala Gly His Leu Glu 
        515                 520                 525             
Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp 
    530                 535                 540                 
Lys Val Gly Tyr Thr Pro Leu His Leu Ala Ala Gln Ser Gly His Leu 
545                 550                 555                 560 
Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys 
                565                 570                 575     
Asp Val Val Gly Val Thr Pro Ala Asp Leu Ala Ala Phe Glu Gly His 
            580                 585                 590         
Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly Ser Pro Thr Pro 
        595                 600                 605             
Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro 
    610                 615                 620                 
Thr Gly Ser Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys 
625                 630                 635                 640 
Leu Leu His Ala Ala Gln Ala Gly Gln Leu Asp Glu Val Arg Ile Leu 
                645                 650                 655     
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr 
            660                 665                 670         
Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val 
        675                 680                 685             
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu 
    690                 695                 700                 
Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu 
705                 710                 715                 720 
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly 
                725                 730                 735     
Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Gln Asp Ile Ala 
            740                 745                 750         
Glu Val Leu Gln Lys Ala Ala 
        755                 

<210> 89
<211> 455
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 89
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Thr 
    210                 215                 220                 
Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Lys Val Gly Tyr Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Lys Asp Val Val Gly Val Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Phe Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys 
                325                 330                 335     
Leu Leu His Ala Ala Gln Ala Gly Gln Leu Asp Glu Val Arg Ile Leu 
            340                 345                 350         
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr 
        355                 360                 365             
Pro Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val 
    370                 375                 380                 
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu 
385                 390                 395                 400 
Thr Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu 
                405                 410                 415     
Val Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly 
            420                 425                 430         
Gln Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Gln Asp Ile Ala 
        435                 440                 445             
Glu Val Leu Gln Lys Ala Ala 
    450                 455 

<210> 90
<211> 463
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 90
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Thr 
    210                 215                 220                 
Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Lys Val Gly Tyr Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Lys Asp Val Val Gly Val Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Phe Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Pro Thr Pro Thr Pro 
                325                 330                 335     
Thr Gly Ser Asp Leu Gly Gln Lys Leu Leu His Ala Ala Gln Ala Gly 
            340                 345                 350         
Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly Ala Asp Val Asn 
        355                 360                 365             
Ala Lys Asp Lys Gln Gly Asn Thr Pro Leu His Ile Ala Ala Phe His 
    370                 375                 380                 
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
385                 390                 395                 400 
Asn Ala Lys Asp Gln Trp Gly Leu Thr Pro Leu His Leu Ala Ala Ala 
                405                 410                 415     
Trp Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp 
            420                 425                 430         
Val Asn Ala Gln Asp Asn Tyr Gly Gln Thr Pro Ala Asp Leu Ala Ala 
        435                 440                 445             
Glu Ser Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala 
    450                 455                 460             

<210> 91
<211> 470
<212> PRT
<213> Artificial Sequence


<220> 
<223> Multi-specific binding protein

<400> 91
Gly Ser Asp Leu Gly Lys Lys Leu Leu Gln Ala Ala Arg Ala Gly Gln 
1               5                   10                  15      
Leu Asp Glu Val Arg Glu Leu Leu Lys Ala Gly Ala Asp Val Asn Ala 
            20                  25                  30          
Lys Asp Arg Glu Gly Lys Thr Pro Leu His Val Ala Ala Gln Glu Gly 
        35                  40                  45              
His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val Asn 
    50                  55                  60                  
Ala Lys Asp Val Trp Gly Arg Thr Pro Leu His Leu Ala Ala Trp Ile 
65                  70                  75                  80  
Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala Gly Ala Asp Val 
                85                  90                  95      
Asn Ala Lys Asp Val Ser Gly Ala Thr Pro Leu His Ala Ala Ala Leu 
            100                 105                 110         
His Gly His Leu Glu Ile Val Glu Val Leu Leu Asn Ala Gly Ala Asp 
        115                 120                 125             
Val Asn Ala Gln Asp Lys Ser Gly Lys Thr Pro Ala Asp Leu Ala Ala 
    130                 135                 140                 
Arg Ala Gly His Gln Asp Ile Ala Glu Val Leu Gln Lys Ala Ala Gly 
145                 150                 155                 160 
Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr Pro Thr Thr Pro 
                165                 170                 175     
Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Lys Lys Leu Leu Leu Ala 
            180                 185                 190         
Ala Arg Ala Gly Gln Leu Asp Glu Val Arg Ile Leu Leu Lys Ala Gly 
        195                 200                 205             
Ala Asp Val Asn Ala Lys Asp Val Phe Gly Gln Thr Pro Leu His Thr 
    210                 215                 220                 
Ala Ala Val Ala Gly His Leu Glu Ile Val Glu Val Leu Leu Lys Ala 
225                 230                 235                 240 
Gly Ala Asp Val Asn Ala Lys Asp Lys Val Gly Tyr Thr Pro Leu His 
                245                 250                 255     
Leu Ala Ala Gln Ser Gly His Leu Glu Ile Val Glu Val Leu Leu Lys 
            260                 265                 270         
Ala Gly Ala Asp Val Asn Ala Lys Asp Val Val Gly Val Thr Pro Ala 
        275                 280                 285             
Asp Leu Ala Ala Phe Glu Gly His Gln Asp Ile Ala Glu Val Leu Gln 
    290                 295                 300                 
Lys Ala Ala Gly Ser Pro Thr Pro Thr Pro Thr Thr Pro Thr Pro Thr 
305                 310                 315                 320 
Pro Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Pro Thr Pro Thr Pro 
                325                 330                 335     
Thr Thr Pro Thr Pro Thr Pro Thr Gly Ser Asp Leu Gly Gln Lys Leu 
            340                 345                 350         
Leu His Ala Ala Gln Ala Gly Gln Leu Asp Glu Val Arg Ile Leu Leu 
        355                 360                 365             
Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Lys Gln Gly Asn Thr Pro 
    370                 375                 380                 
Leu His Ile Ala Ala Phe His Gly His Leu Glu Ile Val Glu Val Leu 
385                 390                 395                 400 
Leu Lys Ala Gly Ala Asp Val Asn Ala Lys Asp Gln Trp Gly Leu Thr 
                405                 410                 415     
Pro Leu His Leu Ala Ala Ala Trp Gly His Leu Glu Ile Val Glu Val 
            420                 425                 430         
Leu Leu Lys Ala Gly Ala Asp Val Asn Ala Gln Asp Asn Tyr Gly Gln 
        435                 440                 445             
Thr Pro Ala Asp Leu Ala Ala Glu Ser Gly His Gln Asp Ile Ala Glu 
    450                 455                 460                 
Val Leu Gln Lys Ala Ala 
465                 470 

<210> 92
<211> 378
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding spike protein binding domain

<400> 92
ggatcagacc tgggtaaaaa gttgttactt gcagctcgcg ccggccaatt ggacgaagtc      60

cgcattttac tgaaggccgg tgcggatgtg aacgcgaaag acgtgtttgg gcagacccct     120

cttcacaccg cagcagttgc aggtcatctg gagatcgtgg aagtgctttt aaaagcgggt     180

gcggacgtca acgctaagga caaagttggg tacacgccac tgcacttagc tgcacagtca     240

ggacatcttg agattgtgga ggtcttgctg aaggcaggcg cagatgtgaa cgctaaggat     300

gtcgttgggg ttacgccggc ggatttggca gctttcgagg gacaccagga cattgctgaa     360

gttctgcaga aggcagca                                                   378


<210> 93
<211> 2253
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 93
ggatccgacc tgggtaaaaa gctgctggag gcagcgcgtg ccggtcaaga cgacgaggtt      60

cgcgaattgc ttaaagcggg tgcagacgtc aacgccaaag attatttctc tcataccccg     120

ttgcatttag ccgcgcgtaa tggccatctg aagatcgtcg aggtcctctt gaaggcaggc     180

gcggatgtca atgcgaagga ttttgcgggc aaaacgccgc tgcacttagc ggcgaacgag     240

ggtcatttag aaatcgttga agtcctgtta aaagcgggcg ccgatgtgaa tgcgcaggat     300

attttcggta aaacgccggc ggacattgcg gcagatgcgg gtcatgaaga tatcgcagaa     360

gtcctgcaga aggcagcagg cagccctaca cctacgccga ctacgcctac gccgactccg     420

actaccccga ctccgacccc gaccggatca gacctgggta aaaagctgct ggaggcagcg     480

cgtgccggtc aagacgacga ggttcgcgaa ttgcttaaag cgggtgcaga cgtcaacgcc     540

aaagattatt tctctcatac cccgttgcat ttagccgcgc gtaatggcca tctgaagatc     600

gtcgaggtcc tcttgaaggc aggcgcggat gtcaatgcga aggattttgc gggcaaaacg     660

ccgctgcact tagcggcgaa cgagggtcat ttagaaatcg ttgaagtcct gttaaaagcg     720

ggcgccgatg tgaatgcgca ggatattttc ggtaaaacgc cggcggacat tgcggcagat     780

gcgggtcatg aagatatcgc agaagtcctg cagaaggcag caggttcccc gacccctacg     840

ccaacgactc cgaccccaac tccaacgacc cctaccccga ccccgaccgg atcagacctg     900

ggtaaaaaac tgctgcaagc agcacgtgca ggtcagctgg atgaagttcg tgaactgctg     960

aaagcaggcg ccgatgttaa tgcaaaagat agagagggca agaccccgct gcatgtggct    1020

gctcaagagg gtcacctgga aattgttgaa gttctgctga aagccggtgc agatgttaat    1080

gcaaaagatg tgtggggcag aaccccgctg catctggctg cttggatcgg tcacctggaa    1140

attgttgaag ttctgctgaa agccggtgca gatgttaatg caaaagatgt gtctggcgct    1200

accccgctgc atgcggctgc tctgcacggt cacctggaaa ttgttgaagt tctgctgaac    1260

gccggtgcag atgttaacgc acaggataaa agcggtaaaa cccctgccga tctggcagct    1320

cgcgccggtc atcaggatat tgctgaagtg ctgcagaagg cagcaggcag ccccacgcca    1380

actcctacaa cccccacacc tacaccgacg acgccgacac cgactccaac cggatcagac    1440

ctgggtaaaa agttgttact tgcagctcgc gccggccaat tggacgaagt ccgcatttta    1500

ctgaaggccg gtgcggatgt gaacgcgaaa gacgtgtttg ggcagacccc tcttcacacc    1560

gcagcagttg caggtcatct ggagatcgtg gaagtgcttt taaaagcggg tgcggacgtc    1620

aacgctaagg acaaagttgg gtacacgcca ctgcacttag ctgcacagtc aggacatctt    1680

gagattgtgg aggtcttgct gaaggcaggc gcagatgtga acgctaagga tgtcgttggg    1740

gttacgccgg cggatttggc agctttcgag ggacaccagg acattgctga agttctgcag    1800

aaggcagcag gttcgccgac cccaacccct accactccaa cgccgacgcc taccactcca    1860

acaccaacac caacgggatc agacctgggt caaaagttgt tacacgcggc tcaagcggga    1920

caattagacg aggtccgtat tctgcttaaa gccggggctg atgtaaatgc aaaagacaaa    1980

cagggcaaca cacccttaca tatcgcggca ttccatggac atctggagat tgtggaagta    2040

ctgctgaaag ccggggcaga tgtcaacgct aaagaccaat ggggattgac cccccttcat    2100

ttggccgctg cctggggcca tttggagatt gtagaggtac ttctgaaggc gggggctgat    2160

gttaatgccc aggataacta tgggcaaact cctgcggatc tggcggctga atctgggcac    2220

caagatattg ctgaagttct gcagaaggcg gca                                 2253


<210> 94
<211> 2277
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 94
ggatccgacc tgggtaaaaa gctgctggag gcagcgcgtg ccggtcaaga cgacgaggtt      60

cgcgaattgc ttaaagcggg tgcagacgtc aacgccaaag attatttctc tcataccccg     120

ttgcatttag ccgcgcgtaa tggccatctg aagatcgtcg aggtcctctt gaaggcaggc     180

gcggatgtca atgcgaagga ttttgcgggc aaaacgccgc tgcacttagc ggcgaacgag     240

ggtcatttag aaatcgttga agtcctgtta aaagcgggcg ccgatgtgaa tgcgcaggat     300

attttcggta aaacgccggc ggacattgcg gcagatgcgg gtcatgaaga tatcgcagaa     360

gtcctgcaga aggcagcagg cagccctaca cctacgccga ctacgcctac gccgactccg     420

actaccccga ctccgacccc gaccggatca gacctgggta aaaagctgct ggaggcagcg     480

cgtgccggtc aagacgacga ggttcgcgaa ttgcttaaag cgggtgcaga cgtcaacgcc     540

aaagattatt tctctcatac cccgttgcat ttagccgcgc gtaatggcca tctgaagatc     600

gtcgaggtcc tcttgaaggc aggcgcggat gtcaatgcga aggattttgc gggcaaaacg     660

ccgctgcact tagcggcgaa cgagggtcat ttagaaatcg ttgaagtcct gttaaaagcg     720

ggcgccgatg tgaatgcgca ggatattttc ggtaaaacgc cggcggacat tgcggcagat     780

gcgggtcatg aagatatcgc agaagtcctg cagaaggcag caggttcccc gacccctacg     840

ccaacgactc cgaccccaac tccaacgacc cctaccccga ccccgaccgg atcagacctg     900

ggtaaaaaac tgctgcaagc agcacgtgca ggtcagctgg atgaagttcg tgaactgctg     960

aaagcaggcg ccgatgttaa tgcaaaagat agagagggca agaccccgct gcatgtggct    1020

gctcaagagg gtcacctgga aattgttgaa gttctgctga aagccggtgc agatgttaat    1080

gcaaaagatg tgtggggcag aaccccgctg catctggctg cttggatcgg tcacctggaa    1140

attgttgaag ttctgctgaa agccggtgca gatgttaatg caaaagatgt gtctggcgct    1200

accccgctgc atgcggctgc tctgcacggt cacctggaaa ttgttgaagt tctgctgaac    1260

gccggtgcag atgttaacgc acaggataaa agcggtaaaa cccctgccga tctggcagct    1320

cgcgccggtc atcaggatat tgctgaagtg ctgcagaagg cagcaggcag ccccacgcca    1380

actcctacaa cccccacacc tacaccgacg acgccgacac cgactccaac cggatcagac    1440

ctgggtaaaa agttgttact tgcagctcgc gccggccaat tggacgaagt ccgcatttta    1500

ctgaaggccg gtgcggatgt gaacgcgaaa gacgtgtttg ggcagacccc tcttcacacc    1560

gcagcagttg caggtcatct ggagatcgtg gaagtgcttt taaaagcggg tgcggacgtc    1620

aacgctaagg acaaagttgg gtacacgcca ctgcacttag ctgcacagtc aggacatctt    1680

gagattgtgg aggtcttgct gaaggcaggc gcagatgtga acgctaagga tgtcgttggg    1740

gttacgccgg cggatttggc agctttcgag ggacaccagg acattgctga agttctgcag    1800

aaggcagcag gttcgccgac cccaacccct accactccaa cgccgacgcc taccactcca    1860

acaccaacac caacgggatc accgacccct accccaacag gatcagacct gggtcaaaag    1920

ttgttacacg cggctcaagc gggacaatta gacgaggtcc gtattctgct taaagccggg    1980

gctgatgtaa atgcaaaaga caaacagggc aacacaccct tacatatcgc ggcattccat    2040

ggacatctgg agattgtgga agtactgctg aaagccgggg cagatgtcaa cgctaaagac    2100

caatggggat tgacccccct tcatttggcc gctgcctggg gccatttgga gattgtagag    2160

gtacttctga aggcgggggc tgatgttaat gcccaggata actatgggca aactcctgcg    2220

gatctggcgg ctgaatctgg gcaccaagat attgctgaag ttctgcagaa ggcggca       2277


<210> 95
<211> 1365
<212> DNA
<213> Artificial Sequence


<220> 
<223> Nucleic acid encoding multi-specific binding protein

<400> 95
ggatcagacc tgggtaaaaa actgctgcaa gcagcacgtg caggtcagct ggatgaagtt      60

cgtgaactgc tgaaagcagg cgccgatgtt aatgcaaaag atagagaggg caagaccccg     120

ctgcatgtgg ctgctcaaga gggtcacctg gaaattgttg aagttctgct gaaagccggt     180

gcagatgtta atgcaaaaga tgtgtggggc agaaccccgc tgcatctggc tgcttggatc     240

ggtcacctgg aaattgttga agttctgctg aaagccggtg cagatgttaa tgcaaaagat     300

gtgtctggcg ctaccccgct gcatgcggct gctctgcacg gtcacctgga aattgttgaa     360

gttctgctga acgccggtgc agatgttaac gcacaggata aaagcggtaa aacccctgcc     420

gatctggcag ctcgcgccgg tcatcaggat attgctgaag tgctgcagaa ggcagcaggc     480

agccccacgc caactcctac aacccccaca cctacaccga cgacgccgac accgactcca     540

accggatcag acctgggtaa aaagttgtta cttgcagctc gcgccggcca attggacgaa     600

gtccgcattt tactgaaggc cggtgcggat gtgaacgcga aagacgtgtt tgggcagacc     660

cctcttcaca ccgcagcagt tgcaggtcat ctggagatcg tggaagtgct tttaaaagcg     720

ggtgcggacg tcaacgctaa ggacaaagtt gggtacacgc cactgcactt agctgcacag     780

tcaggacatc ttgagattgt ggaggtcttg ctgaaggcag gcgcagatgt gaacgctaag     840

gatgtcgttg gggttacgcc ggcggatttg gcagctttcg agggacacca ggacattgct     900

gaagttctgc agaaggcagc aggttcgccg accccaaccc ctaccactcc aacgccgacg     960

cctaccactc caacaccaac accaacggga tcagacctgg gtcaaaagtt gttacacgcg    1020

gctcaagcgg gacaattaga cgaggtccgt attctgctta aagccggggc tgatgtaaat    1080

gcaaaagaca aacagggcaa cacaccctta catatcgcgg cattccatgg acatctggag    1140

attgtggaag tactgctgaa agccggggca gatgtcaacg ctaaagacca atggggattg    1200

accccccttc atttggccgc tgcctggggc catttggaga ttgtagaggt acttctgaag    1260

gcgggggctg atgttaatgc ccaggataac tatgggcaaa ctcctgcgga tctggcggct    1320

gaatctgggc accaagatat tgctgaagtt ctgcagaagg cggca                    1365


