SEQUENCE LISTING

<110> Cellectis S.A. 

<120> METHODS FOR TARGETED INSERTION OF EXOGENOUS SEQUENCES IN CELLULAR GENOMES

<130> P82001820PCT00

<150> US63020900
<151> 2020-05-06

<150> PA202070366
<151> 2020-06-10

<160> 246

<170> PatentIn version 3.5

<210>  1

<211>  1962
<212>  DNA
<213>  homo sapiens

<220>
<223>  IDUA polynucleote sequence

<400>  1
atgcgtcccc tgcgcccccg cgccgcgctg ctggcgctcc tggcctcgct cctggccgcg     60
cccccggtgg ccccggccga ggccccgcac ctggtgcatg tggacgcggc ccgcgcgctg    120
tggcccctgc ggcgcttctg gaggagcaca ggcttctgcc ccccgctgcc acacagccag    180
gctgaccagt acgtcctcag ctgggaccag cagctcaacc tcgcctatgt gggcgccgtc    240
cctcaccgcg gcatcaagca ggtccggacc cactggctgc tggagcttgt caccaccagg    300
gggtccactg gacggggcct gagctacaac ttcacccacc tggacgggta cctggacctt    360
ctcagggaga accagctcct cccagggttt gagctgatgg gcagcgcctc gggccacttc    420
actgactttg aggacaagca gcaggtgttt gagtggaagg acttggtctc cagcctggcc    480
aggagataca tcggtaggta cggactggcg catgtttcca agtggaactt cgagacgtgg    540
aatgagccag accaccacga ctttgacaac gtctccatga ccatgcaagg cttcctgaac    600
tactacgatg cctgctcgga gggtctgcgc gccgccagcc ccgccctgcg gctgggaggc    660
cccggcgact ccttccacac cccaccgcga tccccgctga gctggggcct cctgcgccac    720
tgccacgacg gtaccaactt cttcactggg gaggcgggcg tgcggctgga ctacatctcc    780
ctccacagga agggtgcgcg cagctccatc tccatcctgg agcaggagaa ggtcgtcgcg    840
cagcagatcc ggcagctctt ccccaagttc gcggacaccc ccatttacaa cgacgaggcg    900
gacccgctgg tgggctggtc cctgccacag ccgtggaggg cggacgtgac ctacgcggcc    960
atggtggtga aggtcatcgc gcagcatcag aacctgctac tggccaacac cacctccgcc   1020
ttcccctacg cgctcctgag caacgacaat gccttcctga gctaccaccc gcaccccttc   1080
gcgcagcgca cgctcaccgc gcgcttccag gtcaacaaca cccgcccgcc gcacgtgcag   1140
ctgttgcgca agccggtgct cacggccatg gggctgctgg cgctgctgga tgaggagcag   1200
ctctgggccg aagtgtcgca ggccgggacc gtcctggaca gcaaccacac ggtgggcgtc   1260
ctggccagcg cccaccgccc ccagggcccg gccgacgcct ggcgcgccgc ggtgctgatc   1320
tacgcgagcg acgacacccg cgcccacccc aaccgcagcg tcgcggtgac cctgcggctg   1380
cgcggggtgc cccccggccc gggcctggtc tacgtcacgc gctacctgga caacgggctc   1440
tgcagccccg acggcgagtg gcggcgcctg ggccggcccg tcttccccac ggcagagcag   1500
ttccggcgca tgcgcgcggc tgaggacccg gtggccgcgg cgccccgccc cttacccgcc   1560
ggcggccgcc tgaccctgcg ccccgcgctg cggctgccgt cgcttttgct ggtgcacgtg   1620
tgtgcgcgcc ccgagaagcc gcccgggcag gtcacgcggc tccgcgccct gcccctgacc   1680
caagggcagc tggttctggt ctggtcggat gaacacgtgg gctccaagtg cctgtggaca   1740
tacgagatcc agttctctca ggacggtaag gcgtacaccc cggtcagcag gaagccatcg   1800
accttcaacc tctttgtgtt cagcccagac acaggtgctg tctctggctc ctaccgagtt   1860
cgagccctgg actactgggc ccgaccaggc cccttctcgg accctgtgcc gtacctggag   1920
gtccctgtgc caagagggcc cccatccccg ggcaatccat ga                      1962


<210>  2

<211>  653
<212>  PRT
<213>  homo sapiens

<220>
<223>  IDUA polypeptide sequence

<400>  2
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             


<210>  3

<211>  1962
<212>  DNA
<213>  homo sapiens

<220>
<223>  IDS polynucleotide sequence

<400>  3
atgcgtcccc tgcgcccccg cgccgcgctg ctggcgctcc tggcctcgct cctggccgcg     60
cccccggtgg ccccggccga ggccccgcac ctggtgcatg tggacgcggc ccgcgcgctg    120
tggcccctgc ggcgcttctg gaggagcaca ggcttctgcc ccccgctgcc acacagccag    180
gctgaccagt acgtcctcag ctgggaccag cagctcaacc tcgcctatgt gggcgccgtc    240
cctcaccgcg gcatcaagca ggtccggacc cactggctgc tggagcttgt caccaccagg    300
gggtccactg gacggggcct gagctacaac ttcacccacc tggacgggta cctggacctt    360
ctcagggaga accagctcct cccagggttt gagctgatgg gcagcgcctc gggccacttc    420
actgactttg aggacaagca gcaggtgttt gagtggaagg acttggtctc cagcctggcc    480
aggagataca tcggtaggta cggactggcg catgtttcca agtggaactt cgagacgtgg    540
aatgagccag accaccacga ctttgacaac gtctccatga ccatgcaagg cttcctgaac    600
tactacgatg cctgctcgga gggtctgcgc gccgccagcc ccgccctgcg gctgggaggc    660
cccggcgact ccttccacac cccaccgcga tccccgctga gctggggcct cctgcgccac    720
tgccacgacg gtaccaactt cttcactggg gaggcgggcg tgcggctgga ctacatctcc    780
ctccacagga agggtgcgcg cagctccatc tccatcctgg agcaggagaa ggtcgtcgcg    840
cagcagatcc ggcagctctt ccccaagttc gcggacaccc ccatttacaa cgacgaggcg    900
gacccgctgg tgggctggtc cctgccacag ccgtggaggg cggacgtgac ctacgcggcc    960
atggtggtga aggtcatcgc gcagcatcag aacctgctac tggccaacac cacctccgcc   1020
ttcccctacg cgctcctgag caacgacaat gccttcctga gctaccaccc gcaccccttc   1080
gcgcagcgca cgctcaccgc gcgcttccag gtcaacaaca cccgcccgcc gcacgtgcag   1140
ctgttgcgca agccggtgct cacggccatg gggctgctgg cgctgctgga tgaggagcag   1200
ctctgggccg aagtgtcgca ggccgggacc gtcctggaca gcaaccacac ggtgggcgtc   1260
ctggccagcg cccaccgccc ccagggcccg gccgacgcct ggcgcgccgc ggtgctgatc   1320
tacgcgagcg acgacacccg cgcccacccc aaccgcagcg tcgcggtgac cctgcggctg   1380
cgcggggtgc cccccggccc gggcctggtc tacgtcacgc gctacctgga caacgggctc   1440
tgcagccccg acggcgagtg gcggcgcctg ggccggcccg tcttccccac ggcagagcag   1500
ttccggcgca tgcgcgcggc tgaggacccg gtggccgcgg cgccccgccc cttacccgcc   1560
ggcggccgcc tgaccctgcg ccccgcgctg cggctgccgt cgcttttgct ggtgcacgtg   1620
tgtgcgcgcc ccgagaagcc gcccgggcag gtcacgcggc tccgcgccct gcccctgacc   1680
caagggcagc tggttctggt ctggtcggat gaacacgtgg gctccaagtg cctgtggaca   1740
tacgagatcc agttctctca ggacggtaag gcgtacaccc cggtcagcag gaagccatcg   1800
accttcaacc tctttgtgtt cagcccagac acaggtgctg tctctggctc ctaccgagtt   1860
cgagccctgg actactgggc ccgaccaggc cccttctcgg accctgtgcc gtacctggag   1920
gtccctgtgc caagagggcc cccatccccg ggcaatccat ga                      1962

<210>  4

<211>  653
<212>  PRT
<213>  homo sapiens

<220>
<223>  IDS polypeptide sequence

<400>  4
Met Arg Pro Leu Arg Pro Arg Ala Ala Leu Leu Ala Leu Leu Ala Ser 
1               5                   10                  15      


Leu Leu Ala Ala Pro Pro Val Ala Pro Ala Glu Ala Pro His Leu Val 
            20                  25                  30          


His Val Asp Ala Ala Arg Ala Leu Trp Pro Leu Arg Arg Phe Trp Arg 
        35                  40                  45              


Ser Thr Gly Phe Cys Pro Pro Leu Pro His Ser Gln Ala Asp Gln Tyr 
    50                  55                  60                  


Val Leu Ser Trp Asp Gln Gln Leu Asn Leu Ala Tyr Val Gly Ala Val 
65                  70                  75                  80  


Pro His Arg Gly Ile Lys Gln Val Arg Thr His Trp Leu Leu Glu Leu 
                85                  90                  95      


Val Thr Thr Arg Gly Ser Thr Gly Arg Gly Leu Ser Tyr Asn Phe Thr 
            100                 105                 110         


His Leu Asp Gly Tyr Leu Asp Leu Leu Arg Glu Asn Gln Leu Leu Pro 
        115                 120                 125             


Gly Phe Glu Leu Met Gly Ser Ala Ser Gly His Phe Thr Asp Phe Glu 
    130                 135                 140                 


Asp Lys Gln Gln Val Phe Glu Trp Lys Asp Leu Val Ser Ser Leu Ala 
145                 150                 155                 160 


Arg Arg Tyr Ile Gly Arg Tyr Gly Leu Ala His Val Ser Lys Trp Asn 
                165                 170                 175     


Phe Glu Thr Trp Asn Glu Pro Asp His His Asp Phe Asp Asn Val Ser 
            180                 185                 190         


Met Thr Met Gln Gly Phe Leu Asn Tyr Tyr Asp Ala Cys Ser Glu Gly 
        195                 200                 205             


Leu Arg Ala Ala Ser Pro Ala Leu Arg Leu Gly Gly Pro Gly Asp Ser 
    210                 215                 220                 


Phe His Thr Pro Pro Arg Ser Pro Leu Ser Trp Gly Leu Leu Arg His 
225                 230                 235                 240 


Cys His Asp Gly Thr Asn Phe Phe Thr Gly Glu Ala Gly Val Arg Leu 
                245                 250                 255     


Asp Tyr Ile Ser Leu His Arg Lys Gly Ala Arg Ser Ser Ile Ser Ile 
            260                 265                 270         


Leu Glu Gln Glu Lys Val Val Ala Gln Gln Ile Arg Gln Leu Phe Pro 
        275                 280                 285             


Lys Phe Ala Asp Thr Pro Ile Tyr Asn Asp Glu Ala Asp Pro Leu Val 
    290                 295                 300                 


Gly Trp Ser Leu Pro Gln Pro Trp Arg Ala Asp Val Thr Tyr Ala Ala 
305                 310                 315                 320 


Met Val Val Lys Val Ile Ala Gln His Gln Asn Leu Leu Leu Ala Asn 
                325                 330                 335     


Thr Thr Ser Ala Phe Pro Tyr Ala Leu Leu Ser Asn Asp Asn Ala Phe 
            340                 345                 350         


Leu Ser Tyr His Pro His Pro Phe Ala Gln Arg Thr Leu Thr Ala Arg 
        355                 360                 365             


Phe Gln Val Asn Asn Thr Arg Pro Pro His Val Gln Leu Leu Arg Lys 
    370                 375                 380                 


Pro Val Leu Thr Ala Met Gly Leu Leu Ala Leu Leu Asp Glu Glu Gln 
385                 390                 395                 400 


Leu Trp Ala Glu Val Ser Gln Ala Gly Thr Val Leu Asp Ser Asn His 
                405                 410                 415     


Thr Val Gly Val Leu Ala Ser Ala His Arg Pro Gln Gly Pro Ala Asp 
            420                 425                 430         


Ala Trp Arg Ala Ala Val Leu Ile Tyr Ala Ser Asp Asp Thr Arg Ala 
        435                 440                 445             


His Pro Asn Arg Ser Val Ala Val Thr Leu Arg Leu Arg Gly Val Pro 
    450                 455                 460                 


Pro Gly Pro Gly Leu Val Tyr Val Thr Arg Tyr Leu Asp Asn Gly Leu 
465                 470                 475                 480 


Cys Ser Pro Asp Gly Glu Trp Arg Arg Leu Gly Arg Pro Val Phe Pro 
                485                 490                 495     


Thr Ala Glu Gln Phe Arg Arg Met Arg Ala Ala Glu Asp Pro Val Ala 
            500                 505                 510         


Ala Ala Pro Arg Pro Leu Pro Ala Gly Gly Arg Leu Thr Leu Arg Pro 
        515                 520                 525             


Ala Leu Arg Leu Pro Ser Leu Leu Leu Val His Val Cys Ala Arg Pro 
    530                 535                 540                 


Glu Lys Pro Pro Gly Gln Val Thr Arg Leu Arg Ala Leu Pro Leu Thr 
545                 550                 555                 560 


Gln Gly Gln Leu Val Leu Val Trp Ser Asp Glu His Val Gly Ser Lys 
                565                 570                 575     


Cys Leu Trp Thr Tyr Glu Ile Gln Phe Ser Gln Asp Gly Lys Ala Tyr 
            580                 585                 590         


Thr Pro Val Ser Arg Lys Pro Ser Thr Phe Asn Leu Phe Val Phe Ser 
        595                 600                 605             


Pro Asp Thr Gly Ala Val Ser Gly Ser Tyr Arg Val Arg Ala Leu Asp 
    610                 615                 620                 


Tyr Trp Ala Arg Pro Gly Pro Phe Ser Asp Pro Val Pro Tyr Leu Glu 
625                 630                 635                 640 


Val Pro Val Pro Arg Gly Pro Pro Ser Pro Gly Asn Pro 
                645                 650             

<210>  5

<211>  1956
<212>  DNA
<213>  homo sapiens

<220>
<223>  ARSB polynucleotide sequence

<400>  5
atggcccggg ggtcggcggt tgcctgggcg gcgctcgggc cgttgttgtg gggctgcgcg     60
ctggggctgc agggcgggat gctgtacccc caggagagcc cgtcgcggga gtgcaaggag    120
ctggacggcc tctggagctt ccgcgccgac ttctctgaca accgacgccg gggcttcgag    180
gagcagtggt accggcggcc gctgtgggag tcaggcccca ccgtggacat gccagttccc    240
tccagcttca atgacatcag ccaggactgg cgtctgcggc attttgtcgg ctgggtgtgg    300
tacgaacggg aggtgatcct gccggagcga tggacccagg acctgcgcac aagagtggtg    360
ctgaggattg gcagtgccca ttcctatgcc atcgtgtggg tgaatggggt cgacacgcta    420
gagcatgagg ggggctacct ccccttcgag gccgacatca gcaacctggt ccaggtgggg    480
cccctgccct cccggctccg aatcactatc gccatcaaca acacactcac ccccaccacc    540
ctgccaccag ggaccatcca atacctgact gacacctcca agtatcccaa gggttacttt    600
gtccagaaca catattttga ctttttcaac tacgctggac tgcagcggtc tgtacttctg    660
tacacgacac ccaccaccta catcgatgac atcaccgtca ccaccagcgt ggagcaagac    720
agtgggctgg tgaattacca gatctctgtc aagggcagta acctgttcaa gttggaagtg    780
cgtcttttgg atgcagaaaa caaagtcgtg gcgaatggga ctgggaccca gggccaactt    840
aaggtgccag gtgtcagcct ctggtggccg tacctgatgc acgaacgccc tgcctatctg    900
tattcattgg aggtgcagct gactgcacag acgtcactgg ggcctgtgtc tgacttctac    960
acactccctg tggggatccg cactgtggct gtcaccaaga gccagttcct catcaatggg   1020
aaacctttct atttccacgg tgtcaacaag catgaggatg cggacatccg agggaagggc   1080
ttcgactggc cgctgctggt gaaggacttc aacctgcttc gctggcttgg tgccaacgct   1140
ttccgtacca gccactaccc ctatgcagag gaagtgatgc agatgtgtga ccgctatggg   1200
attgtggtca tcgatgagtg tcccggcgtg ggcctggcgc tgccgcagtt cttcaacaac   1260
gtttctctgc atcaccacat gcaggtgatg gaagaagtgg tgcgtaggga caagaaccac   1320
cccgcggtcg tgatgtggtc tgtggccaac gagcctgcgt cccacctaga atctgctggc   1380
tactacttga agatggtgat cgctcacacc aaatccttgg acccctcccg gcctgtgacc   1440
tttgtgagca actctaacta tgcagcagac aagggggctc cgtatgtgga tgtgatctgt   1500
ttgaacagct actactcttg gtatcacgac tacgggcacc tggagttgat tcagctgcag   1560
ctggccaccc agtttgagaa ctggtataag aagtatcaga agcccattat tcagagcgag   1620
tatggagcag aaacgattgc agggtttcac caggatccac ctctgatgtt cactgaagag   1680
taccagaaaa gtctgctaga gcagtaccat ctgggtctgg atcaaaaacg cagaaaatac   1740
gtggttggag agctcatttg gaattttgcc gatttcatga ctgaacagtc accgacgaga   1800
gtgctgggga ataaaaaggg gatcttcact cggcagagac aaccaaaaag tgcagcgttc   1860
cttttgcgag agagatactg gaagattgcc aatgaaacca ggtatcccca ctcagtagcc   1920
aagtcacaat gtttggaaaa cagcctgttt acttga                             1956

<210>  6

<211>  533
<212>  PRT
<213>  homo sapiens

<220>
<223>  ARSB polypeptide sequence

<400>  6
Met Gly Pro Arg Gly Ala Ala Ser Leu Pro Arg Gly Pro Gly Pro Arg 
1               5                   10                  15      


Arg Leu Leu Leu Pro Val Val Leu Pro Leu Leu Leu Leu Leu Leu Leu 
            20                  25                  30          


Ala Pro Pro Gly Ser Gly Ala Gly Ala Ser Arg Pro Pro His Leu Val 
        35                  40                  45              


Phe Leu Leu Ala Asp Asp Leu Gly Trp Asn Asp Val Gly Phe His Gly 
    50                  55                  60                  


Ser Arg Ile Arg Thr Pro His Leu Asp Ala Leu Ala Ala Gly Gly Val 
65                  70                  75                  80  


Leu Leu Asp Asn Tyr Tyr Thr Gln Pro Leu Cys Thr Pro Ser Arg Ser 
                85                  90                  95      


Gln Leu Leu Thr Gly Arg Tyr Gln Ile Arg Thr Gly Leu Gln His Gln 
            100                 105                 110         


Ile Ile Trp Pro Cys Gln Pro Ser Cys Val Pro Leu Asp Glu Lys Leu 
        115                 120                 125             


Leu Pro Gln Leu Leu Lys Glu Ala Gly Tyr Thr Thr His Met Val Gly 
    130                 135                 140                 


Lys Trp His Leu Gly Met Tyr Arg Lys Glu Cys Leu Pro Thr Arg Arg 
145                 150                 155                 160 


Gly Phe Asp Thr Tyr Phe Gly Tyr Leu Leu Gly Ser Glu Asp Tyr Tyr 
                165                 170                 175     


Ser His Glu Arg Cys Thr Leu Ile Asp Ala Leu Asn Val Thr Arg Cys 
            180                 185                 190         


Ala Leu Asp Phe Arg Asp Gly Glu Glu Val Ala Thr Gly Tyr Lys Asn 
        195                 200                 205             


Met Tyr Ser Thr Asn Ile Phe Thr Lys Arg Ala Ile Ala Leu Ile Thr 
    210                 215                 220                 


Asn His Pro Pro Glu Lys Pro Leu Phe Leu Tyr Leu Ala Leu Gln Ser 
225                 230                 235                 240 


Val His Glu Pro Leu Gln Val Pro Glu Glu Tyr Leu Lys Pro Tyr Asp 
                245                 250                 255     


Phe Ile Gln Asp Lys Asn Arg His His Tyr Ala Gly Met Val Ser Leu 
            260                 265                 270         


Met Asp Glu Ala Val Gly Asn Val Thr Ala Ala Leu Lys Ser Ser Gly 
        275                 280                 285             


Leu Trp Asn Asn Thr Val Phe Ile Phe Ser Thr Asp Asn Gly Gly Gln 
    290                 295                 300                 


Thr Leu Ala Gly Gly Asn Asn Trp Pro Leu Arg Gly Arg Lys Trp Ser 
305                 310                 315                 320 


Leu Trp Glu Gly Gly Val Arg Gly Val Gly Phe Val Ala Ser Pro Leu 
                325                 330                 335     


Leu Lys Gln Lys Gly Val Lys Asn Arg Glu Leu Ile His Ile Ser Asp 
            340                 345                 350         


Trp Leu Pro Thr Leu Val Lys Leu Ala Arg Gly His Thr Asn Gly Thr 
        355                 360                 365             


Lys Pro Leu Asp Gly Phe Asp Val Trp Lys Thr Ile Ser Glu Gly Ser 
    370                 375                 380                 


Pro Ser Pro Arg Ile Glu Leu Leu His Asn Ile Asp Pro Asn Phe Val 
385                 390                 395                 400 


Asp Ser Ser Pro Cys Pro Arg Asn Ser Met Ala Pro Ala Lys Asp Asp 
                405                 410                 415     


Ser Ser Leu Pro Glu Tyr Ser Ala Phe Asn Thr Ser Val His Ala Ala 
            420                 425                 430         


Ile Arg His Gly Asn Trp Lys Leu Leu Thr Gly Tyr Pro Gly Cys Gly 
        435                 440                 445             


Tyr Trp Phe Pro Pro Pro Ser Gln Tyr Asn Val Ser Glu Ile Pro Ser 
    450                 455                 460                 


Ser Asp Pro Pro Thr Lys Thr Leu Trp Leu Phe Asp Ile Asp Arg Asp 
465                 470                 475                 480 


Pro Glu Glu Arg His Asp Leu Ser Arg Glu Tyr Pro His Ile Val Thr 
                485                 490                 495     


Lys Leu Leu Ser Arg Leu Gln Phe Tyr His Lys His Ser Val Pro Val 
            500                 505                 510         


Tyr Phe Pro Ala Gln Asp Pro Arg Cys Asp Pro Lys Ala Thr Gly Val 
        515                 520                 525             


Trp Gly Pro Trp Met 
    530             

<210>  7

<211>  1956
<212>  DNA
<213>  homo sapiens

<220>
<223>  GUSB polynucleotide sequence

<400>  7
atggcccggg ggtcggcggt tgcctgggcg gcgctcgggc cgttgttgtg gggctgcgcg     60
ctggggctgc agggcgggat gctgtacccc caggagagcc cgtcgcggga gtgcaaggag    120
ctggacggcc tctggagctt ccgcgccgac ttctctgaca accgacgccg gggcttcgag    180
gagcagtggt accggcggcc gctgtgggag tcaggcccca ccgtggacat gccagttccc    240
tccagcttca atgacatcag ccaggactgg cgtctgcggc attttgtcgg ctgggtgtgg    300
tacgaacggg aggtgatcct gccggagcga tggacccagg acctgcgcac aagagtggtg    360
ctgaggattg gcagtgccca ttcctatgcc atcgtgtggg tgaatggggt cgacacgcta    420
gagcatgagg ggggctacct ccccttcgag gccgacatca gcaacctggt ccaggtgggg    480
cccctgccct cccggctccg aatcactatc gccatcaaca acacactcac ccccaccacc    540
ctgccaccag ggaccatcca atacctgact gacacctcca agtatcccaa gggttacttt    600
gtccagaaca catattttga ctttttcaac tacgctggac tgcagcggtc tgtacttctg    660
tacacgacac ccaccaccta catcgatgac atcaccgtca ccaccagcgt ggagcaagac    720
agtgggctgg tgaattacca gatctctgtc aagggcagta acctgttcaa gttggaagtg    780
cgtcttttgg atgcagaaaa caaagtcgtg gcgaatggga ctgggaccca gggccaactt    840
aaggtgccag gtgtcagcct ctggtggccg tacctgatgc acgaacgccc tgcctatctg    900
tattcattgg aggtgcagct gactgcacag acgtcactgg ggcctgtgtc tgacttctac    960
acactccctg tggggatccg cactgtggct gtcaccaaga gccagttcct catcaatggg   1020
aaacctttct atttccacgg tgtcaacaag catgaggatg cggacatccg agggaagggc   1080
ttcgactggc cgctgctggt gaaggacttc aacctgcttc gctggcttgg tgccaacgct   1140
ttccgtacca gccactaccc ctatgcagag gaagtgatgc agatgtgtga ccgctatggg   1200
attgtggtca tcgatgagtg tcccggcgtg ggcctggcgc tgccgcagtt cttcaacaac   1260
gtttctctgc atcaccacat gcaggtgatg gaagaagtgg tgcgtaggga caagaaccac   1320
cccgcggtcg tgatgtggtc tgtggccaac gagcctgcgt cccacctaga atctgctggc   1380
tactacttga agatggtgat cgctcacacc aaatccttgg acccctcccg gcctgtgacc   1440
tttgtgagca actctaacta tgcagcagac aagggggctc cgtatgtgga tgtgatctgt   1500
ttgaacagct actactcttg gtatcacgac tacgggcacc tggagttgat tcagctgcag   1560
ctggccaccc agtttgagaa ctggtataag aagtatcaga agcccattat tcagagcgag   1620
tatggagcag aaacgattgc agggtttcac caggatccac ctctgatgtt cactgaagag   1680
taccagaaaa gtctgctaga gcagtaccat ctgggtctgg atcaaaaacg cagaaaatac   1740
gtggttggag agctcatttg gaattttgcc gatttcatga ctgaacagtc accgacgaga   1800
gtgctgggga ataaaaaggg gatcttcact cggcagagac aaccaaaaag tgcagcgttc   1860
cttttgcgag agagatactg gaagattgcc aatgaaacca ggtatcccca ctcagtagcc   1920
aagtcacaat gtttggaaaa cagcctgttt acttga                             1956

<210>  8

<211>  651
<212>  PRT
<213>  homo sapiens

<220>
<223>  GUSB polypeptide sequence

<400>  8
Met Ala Arg Gly Ser Ala Val Ala Trp Ala Ala Leu Gly Pro Leu Leu 
1               5                   10                  15      


Trp Gly Cys Ala Leu Gly Leu Gln Gly Gly Met Leu Tyr Pro Gln Glu 
            20                  25                  30          


Ser Pro Ser Arg Glu Cys Lys Glu Leu Asp Gly Leu Trp Ser Phe Arg 
        35                  40                  45              


Ala Asp Phe Ser Asp Asn Arg Arg Arg Gly Phe Glu Glu Gln Trp Tyr 
    50                  55                  60                  


Arg Arg Pro Leu Trp Glu Ser Gly Pro Thr Val Asp Met Pro Val Pro 
65                  70                  75                  80  


Ser Ser Phe Asn Asp Ile Ser Gln Asp Trp Arg Leu Arg His Phe Val 
                85                  90                  95      


Gly Trp Val Trp Tyr Glu Arg Glu Val Ile Leu Pro Glu Arg Trp Thr 
            100                 105                 110         


Gln Asp Leu Arg Thr Arg Val Val Leu Arg Ile Gly Ser Ala His Ser 
        115                 120                 125             


Tyr Ala Ile Val Trp Val Asn Gly Val Asp Thr Leu Glu His Glu Gly 
    130                 135                 140                 


Gly Tyr Leu Pro Phe Glu Ala Asp Ile Ser Asn Leu Val Gln Val Gly 
145                 150                 155                 160 


Pro Leu Pro Ser Arg Leu Arg Ile Thr Ile Ala Ile Asn Asn Thr Leu 
                165                 170                 175     


Thr Pro Thr Thr Leu Pro Pro Gly Thr Ile Gln Tyr Leu Thr Asp Thr 
            180                 185                 190         


Ser Lys Tyr Pro Lys Gly Tyr Phe Val Gln Asn Thr Tyr Phe Asp Phe 
        195                 200                 205             


Phe Asn Tyr Ala Gly Leu Gln Arg Ser Val Leu Leu Tyr Thr Thr Pro 
    210                 215                 220                 


Thr Thr Tyr Ile Asp Asp Ile Thr Val Thr Thr Ser Val Glu Gln Asp 
225                 230                 235                 240 


Ser Gly Leu Val Asn Tyr Gln Ile Ser Val Lys Gly Ser Asn Leu Phe 
                245                 250                 255     


Lys Leu Glu Val Arg Leu Leu Asp Ala Glu Asn Lys Val Val Ala Asn 
            260                 265                 270         


Gly Thr Gly Thr Gln Gly Gln Leu Lys Val Pro Gly Val Ser Leu Trp 
        275                 280                 285             


Trp Pro Tyr Leu Met His Glu Arg Pro Ala Tyr Leu Tyr Ser Leu Glu 
    290                 295                 300                 


Val Gln Leu Thr Ala Gln Thr Ser Leu Gly Pro Val Ser Asp Phe Tyr 
305                 310                 315                 320 


Thr Leu Pro Val Gly Ile Arg Thr Val Ala Val Thr Lys Ser Gln Phe 
                325                 330                 335     


Leu Ile Asn Gly Lys Pro Phe Tyr Phe His Gly Val Asn Lys His Glu 
            340                 345                 350         


Asp Ala Asp Ile Arg Gly Lys Gly Phe Asp Trp Pro Leu Leu Val Lys 
        355                 360                 365             


Asp Phe Asn Leu Leu Arg Trp Leu Gly Ala Asn Ala Phe Arg Thr Ser 
    370                 375                 380                 


His Tyr Pro Tyr Ala Glu Glu Val Met Gln Met Cys Asp Arg Tyr Gly 
385                 390                 395                 400 


Ile Val Val Ile Asp Glu Cys Pro Gly Val Gly Leu Ala Leu Pro Gln 
                405                 410                 415     


Phe Phe Asn Asn Val Ser Leu His His His Met Gln Val Met Glu Glu 
            420                 425                 430         


Val Val Arg Arg Asp Lys Asn His Pro Ala Val Val Met Trp Ser Val 
        435                 440                 445             


Ala Asn Glu Pro Ala Ser His Leu Glu Ser Ala Gly Tyr Tyr Leu Lys 
    450                 455                 460                 


Met Val Ile Ala His Thr Lys Ser Leu Asp Pro Ser Arg Pro Val Thr 
465                 470                 475                 480 


Phe Val Ser Asn Ser Asn Tyr Ala Ala Asp Lys Gly Ala Pro Tyr Val 
                485                 490                 495     


Asp Val Ile Cys Leu Asn Ser Tyr Tyr Ser Trp Tyr His Asp Tyr Gly 
            500                 505                 510         


His Leu Glu Leu Ile Gln Leu Gln Leu Ala Thr Gln Phe Glu Asn Trp 
        515                 520                 525             


Tyr Lys Lys Tyr Gln Lys Pro Ile Ile Gln Ser Glu Tyr Gly Ala Glu 
    530                 535                 540                 


Thr Ile Ala Gly Phe His Gln Asp Pro Pro Leu Met Phe Thr Glu Glu 
545                 550                 555                 560 


Tyr Gln Lys Ser Leu Leu Glu Gln Tyr His Leu Gly Leu Asp Gln Lys 
                565                 570                 575     


Arg Arg Lys Tyr Val Val Gly Glu Leu Ile Trp Asn Phe Ala Asp Phe 
            580                 585                 590         


Met Thr Glu Gln Ser Pro Thr Arg Val Leu Gly Asn Lys Lys Gly Ile 
        595                 600                 605             


Phe Thr Arg Gln Arg Gln Pro Lys Ser Ala Ala Phe Leu Leu Arg Glu 
    610                 615                 620                 


Arg Tyr Trp Lys Ile Ala Asn Glu Thr Arg Tyr Pro His Ser Val Ala 
625                 630                 635                 640 


Lys Ser Gln Cys Leu Glu Asn Ser Leu Phe Thr 
                645                 650     


<210>  9

<211>  2238
<212>  DNA
<213>  homo sapiens

<220>
<223>  ABCD1 polynucleotide sequence

<400>  9
atgccggtgc tctccaggcc ccggccctgg cgggggaaca cgctgaagcg cacggccgtg     60
ctcctggccc tcgcggccta tggagcccac aaagtctacc ccttggtgcg ccagtgcctg    120
gccccggcca ggggtcttca ggcgcccgcc ggggagccca cgcaggaggc ctccggggtc    180
gcggcggcca aagctggcat gaaccgggta ttcctgcagc ggctcctgtg gctcctgcgg    240
ctgctgttcc cccgggtcct gtgccgggag acggggctgc tggccctgca ctcggccgcc    300
ttggtgagcc gcaccttcct gtcggtgtat gtggcccgcc tggacggaag gctggcccgc    360
tgcatcgtcc gcaaggaccc gcgggctttt ggctggcagc tgctgcagtg gctcctcatc    420
gccctccctg ctaccttcgt caacagtgcc atccgttacc tggagggcca actggccctg    480
tcgttccgca gccgtctggt ggcccacgcc taccgcctct acttctccca gcagacctac    540
taccgggtca gcaacatgga cgggcggctt cgcaaccctg accagtctct gacggaggac    600
gtggtggcct ttgcggcctc tgtggcccac ctctactcca acctgaccaa gccactcctg    660
gacgtggctg tgacttccta caccctgctt cgggcggccc gctcccgtgg agccggcaca    720
gcctggccct cggccatcgc cggcctcgtg gtgttcctca cggccaacgt gctgcgggcc    780
ttctcgccca agttcgggga gctggtggca gaggaggcgc ggcggaaggg ggagctgcgc    840
tacatgcact cgcgtgtggt ggccaactcg gaggagatcg ccttctatgg gggccatgag    900
gtggagctgg ccctgctaca gcgctcctac caggacctgg cctcgcagat caacctcatc    960
cttctggaac gcctgtggta tgttatgctg gagcagttcc tcatgaagta tgtgtggagc   1020
gcctcgggcc tgctcatggt ggctgtcccc atcatcactg ccactggcta ctcagagtca   1080
gatgcagagg ccgtgaagaa ggcagccttg gaaaagaagg aggaggagct ggtgagcgag   1140
cgcacagaag ccttcactat tgcccgcaac ctcctgacag cggctgcaga tgccattgag   1200
cggatcatgt cgtcgtacaa ggaggtgacg gagctggctg gctacacagc ccgggtgcac   1260
gagatgttcc aggtatttga agatgttcag cgctgtcact tcaagaggcc cagggagcta   1320
gaggacgctc aggcggggtc tgggaccata ggccggtctg gtgtccgtgt ggagggcccc   1380
ctgaagatcc gaggccaggt ggtggatgtg gaacagggga tcatctgcga gaacatcccc   1440
atcgtcacgc cctcaggaga ggtggtggtg gccagcctca acatcagggt ggaggaaggc   1500
atgcatctgc tcatcacagg ccccaatggc tgcggcaaga gctccctgtt ccggatcctg   1560
ggtgggctct ggcccacgta cggtggtgtg ctctacaagc ccccacccca gcgcatgttc   1620
tacatcccgc agaggcccta catgtctgtg ggctccctgc gtgaccaggt gatctacccg   1680
gactcagtgg aggacatgca aaggaagggc tactcggagc aggacctgga agccatcctg   1740
gacgtcgtgc acctgcacca catcctgcag cgggagggag gttgggaggc tatgtgtgac   1800
tggaaggacg tcctgtcggg tggcgagaag cagagaatcg gcatggcccg catgttctac   1860
cacaggccca agtacgccct cctggatgaa tgcaccagcg ccgtgagcat cgacgtggaa   1920
ggcaagatct tccaggcggc caaggacgcg ggcattgccc tgctctccat cacccaccgg   1980
ccctccctgt ggaaatacca cacacacttg ctacagttcg atggggaggg cggctggaag   2040
ttcgagaagc tggactcagc tgcccgcctg agcctgacgg aggagaagca gcggctggag   2100
cagcagctgg cgggcattcc caagatgcag cggcgcctcc aggagctctg ccagatcctg   2160
ggcgaggccg tggccccagc gcatgtgccg gcacctagcc cgcaaggccc tggtggcctc   2220
cagggtgcct ccacctga                                                 2238


<210>  10

<211>  745
<212>  PRT
<213>  homo sapiens

<220>
<223>  ABCD1 polypeptide sequence

<400>  10
Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys 
1               5                   10                  15      


Arg Thr Ala Val Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val 
            20                  25                  30          


Tyr Pro Leu Val Arg Gln Cys Leu Ala Pro Ala Arg Gly Leu Gln Ala 
        35                  40                  45              


Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val Ala Ala Ala Lys 
    50                  55                  60                  


Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 
65                  70                  75                  80  


Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu 
                85                  90                  95      


His Ser Ala Ala Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala 
            100                 105                 110         


Arg Leu Asp Gly Arg Leu Ala Arg Cys Ile Val Arg Lys Asp Pro Arg 
        115                 120                 125             


Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile Ala Leu Pro Ala 
    130                 135                 140                 


Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 
145                 150                 155                 160 


Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser 
                165                 170                 175     


Gln Gln Thr Tyr Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn 
            180                 185                 190         


Pro Asp Gln Ser Leu Thr Glu Asp Val Val Ala Phe Ala Ala Ser Val 
        195                 200                 205             


Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu Asp Val Ala Val 
    210                 215                 220                 


Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 
225                 230                 235                 240 


Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn 
                245                 250                 255     


Val Leu Arg Ala Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu 
            260                 265                 270         


Ala Arg Arg Lys Gly Glu Leu Arg Tyr Met His Ser Arg Val Val Ala 
        275                 280                 285             


Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu Val Glu Leu Ala 
    290                 295                 300                 


Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 
305                 310                 315                 320 


Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys 
                325                 330                 335     


Tyr Val Trp Ser Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile 
            340                 345                 350         


Thr Ala Thr Gly Tyr Ser Glu Ser Asp Ala Glu Ala Val Lys Lys Ala 
        355                 360                 365             


Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu Arg Thr Glu Ala 
    370                 375                 380                 


Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 
385                 390                 395                 400 


Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr 
                405                 410                 415     


Ala Arg Val His Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys 
            420                 425                 430         


His Phe Lys Arg Pro Arg Glu Leu Glu Asp Ala Gln Ala Gly Ser Gly 
        435                 440                 445             


Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro Leu Lys Ile Arg 
    450                 455                 460                 


Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 
465                 470                 475                 480 


Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg 
                485                 490                 495     


Val Glu Glu Gly Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly 
            500                 505                 510         


Lys Ser Ser Leu Phe Arg Ile Leu Gly Gly Leu Trp Pro Thr Tyr Gly 
        515                 520                 525             


Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe Tyr Ile Pro Gln 
    530                 535                 540                 


Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 
545                 550                 555                 560 


Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu 
                565                 570                 575     


Glu Ala Ile Leu Asp Val Val His Leu His His Ile Leu Gln Arg Glu 
            580                 585                 590         


Gly Gly Trp Glu Ala Met Cys Asp Trp Lys Asp Val Leu Ser Gly Gly 
        595                 600                 605             


Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr His Arg Pro Lys 
    610                 615                 620                 


Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 
625                 630                 635                 640 


Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser 
                645                 650                 655     


Ile Thr His Arg Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln 
            660                 665                 670         


Phe Asp Gly Glu Gly Gly Trp Lys Phe Glu Lys Leu Asp Ser Ala Ala 
        675                 680                 685             


Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu Gln Gln Leu Ala 
    690                 695                 700                 


Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 
705                 710                 715                 720 


Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly 
                725                 730                 735     


Pro Gly Gly Leu Gln Gly Ala Ser Thr 
            740                 745 


<210>  11

<211>  2058
<212>  DNA
<213>  homo sapiens

<220>
<223>  GALC polynucleotide sequence

<400>  11
atggctgagt ggctactctc ggcttcctgg caacgccgag cgaaagctat gactgcggcc     60
gcgggttcgg cgggccgcgc cgcggtgccc ttgctgctgt gtgcgctgct ggcgcccggc    120
ggcgcgtacg tgctcgacga ctccgacggg ctgggccggg agttcgacgg catcggcgcg    180
gtcagcggcg gcggggcaac ctcccgactt ctagtaaatt acccagagcc ctatcgttct    240
cagatattgg attatctctt taagccgaat tttggtgcct ctttgcatat tttaaaagtg    300
gaaataggtg gtgatgggca gacaacagac ggcactgagc cctcccacat gcattatgca    360
ctagatgaga attatttccg aggatacgag tggtggttga tgaaagaagc taagaagagg    420
aatcccaata ttacactcat tgggttgcca tggtcattcc ctggatggct gggaaaaggt    480
ttcgactggc cttatgtcaa tcttcagctg actgcctatt atgtcgtgac ctggattgtg    540
ggcgccaagc gttaccatga tttggacatt gattatattg gaatttggaa tgagaggtca    600
tataatgcca attatattaa gatattaaga aaaatgctga attatcaagg tctccagcga    660
gtgaaaatca tagcaagtga taatctctgg gagtccatct ctgcatccat gctccttgat    720
gccgaactct tcaaggtggt tgatgttata ggggctcatt atcctggaac ccattcagca    780
aaagatgcaa agttgactgg gaagaagctt tggtcttctg aagactttag cactttaaat    840
agtgacatgg gtgcaggctg ctggggtcgc attttaaatc agaattatat caatggctat    900
atgacttcca caatcgcatg gaatttagtg gctagttact atgaacagtt gccttatggg    960
agatgcgggt tgatgacggc ccaggagcca tggagtgggc actacgtggt agaatctcct   1020
gtctgggtat cagctcatac cactcagttt actcaacctg gctggtatta cctgaagaca   1080
gttggccatt tagagaaagg aggaagctac gtagctctga ctgatggctt agggaacctc   1140
accatcatca ttgaaaccat gagtcataaa cattctaagt gcatacggcc atttcttcct   1200
tatttcaatg tgtcacaaca atttgccacc tttgttctta agggatcttt tagtgaaata   1260
ccagagctac aggtatggta taccaaactt ggaaaaacat ccgaaagatt tctttttaag   1320
cagctggatt ctctatggct ccttgacagc gatggcagtt tcacactgag cctgcatgaa   1380
gatgagctgt tcacactcac cactctcacc actggtcgca aaggcagcta cccgcttcct   1440
ccaaaatccc agcccttccc aagtacctat aaggatgatt tcaatgttga ttacccattt   1500
tttagtgaag ctccaaactt tgctgatcaa actggtgtat ttgaatattt tacaaatatt   1560
gaagaccctg gcgagcatca cttcacgcta cgccaagttc tcaaccagag acccattaca   1620
tgggctgccg atgcatccaa cacaatcagt attataggag actacaactg gaccaatctg   1680
actataaagt gtgatgtata catagagacc cctgacacag gaggtgtgtt cattgcagga   1740
agagtaaata aaggtggtat tttgattaga agtgccagag gaattttctt ctggattttt   1800
gcaaatggat cttacagggt tacaggtgat ttagctggat ggattatata tgctttagga   1860
cgtgttgaag ttacagcaaa aaaatggtat acactcacgt taactattaa gggtcatttc   1920
acctctggca tgctgaatga caagtctctg tggacagaca tccctgtgaa ttttccaaag   1980
aatggctggg ctgcaattgg aactcactcc tttgaatttg cacagtttga caactttctt   2040
gtggaagcca cacgctaa                                                 2058

<210>  12

<211>  685
<212>  PRT
<213>  homo sapiens

<220>
<223>  GALC  polypeptide sequence

<400>  12
Met Ala Glu Trp Leu Leu Ser Ala Ser Trp Gln Arg Arg Ala Lys Ala 
1               5                   10                  15      


Met Thr Ala Ala Ala Gly Ser Ala Gly Arg Ala Ala Val Pro Leu Leu 
            20                  25                  30          


Leu Cys Ala Leu Leu Ala Pro Gly Gly Ala Tyr Val Leu Asp Asp Ser 
        35                  40                  45              


Asp Gly Leu Gly Arg Glu Phe Asp Gly Ile Gly Ala Val Ser Gly Gly 
    50                  55                  60                  


Gly Ala Thr Ser Arg Leu Leu Val Asn Tyr Pro Glu Pro Tyr Arg Ser 
65                  70                  75                  80  


Gln Ile Leu Asp Tyr Leu Phe Lys Pro Asn Phe Gly Ala Ser Leu His 
                85                  90                  95      


Ile Leu Lys Val Glu Ile Gly Gly Asp Gly Gln Thr Thr Asp Gly Thr 
            100                 105                 110         


Glu Pro Ser His Met His Tyr Ala Leu Asp Glu Asn Tyr Phe Arg Gly 
        115                 120                 125             


Tyr Glu Trp Trp Leu Met Lys Glu Ala Lys Lys Arg Asn Pro Asn Ile 
    130                 135                 140                 


Thr Leu Ile Gly Leu Pro Trp Ser Phe Pro Gly Trp Leu Gly Lys Gly 
145                 150                 155                 160 


Phe Asp Trp Pro Tyr Val Asn Leu Gln Leu Thr Ala Tyr Tyr Val Val 
                165                 170                 175     


Thr Trp Ile Val Gly Ala Lys Arg Tyr His Asp Leu Asp Ile Asp Tyr 
            180                 185                 190         


Ile Gly Ile Trp Asn Glu Arg Ser Tyr Asn Ala Asn Tyr Ile Lys Ile 
        195                 200                 205             


Leu Arg Lys Met Leu Asn Tyr Gln Gly Leu Gln Arg Val Lys Ile Ile 
    210                 215                 220                 


Ala Ser Asp Asn Leu Trp Glu Ser Ile Ser Ala Ser Met Leu Leu Asp 
225                 230                 235                 240 


Ala Glu Leu Phe Lys Val Val Asp Val Ile Gly Ala His Tyr Pro Gly 
                245                 250                 255     


Thr His Ser Ala Lys Asp Ala Lys Leu Thr Gly Lys Lys Leu Trp Ser 
            260                 265                 270         


Ser Glu Asp Phe Ser Thr Leu Asn Ser Asp Met Gly Ala Gly Cys Trp 
        275                 280                 285             


Gly Arg Ile Leu Asn Gln Asn Tyr Ile Asn Gly Tyr Met Thr Ser Thr 
    290                 295                 300                 


Ile Ala Trp Asn Leu Val Ala Ser Tyr Tyr Glu Gln Leu Pro Tyr Gly 
305                 310                 315                 320 


Arg Cys Gly Leu Met Thr Ala Gln Glu Pro Trp Ser Gly His Tyr Val 
                325                 330                 335     


Val Glu Ser Pro Val Trp Val Ser Ala His Thr Thr Gln Phe Thr Gln 
            340                 345                 350         


Pro Gly Trp Tyr Tyr Leu Lys Thr Val Gly His Leu Glu Lys Gly Gly 
        355                 360                 365             


Ser Tyr Val Ala Leu Thr Asp Gly Leu Gly Asn Leu Thr Ile Ile Ile 
    370                 375                 380                 


Glu Thr Met Ser His Lys His Ser Lys Cys Ile Arg Pro Phe Leu Pro 
385                 390                 395                 400 


Tyr Phe Asn Val Ser Gln Gln Phe Ala Thr Phe Val Leu Lys Gly Ser 
                405                 410                 415     


Phe Ser Glu Ile Pro Glu Leu Gln Val Trp Tyr Thr Lys Leu Gly Lys 
            420                 425                 430         


Thr Ser Glu Arg Phe Leu Phe Lys Gln Leu Asp Ser Leu Trp Leu Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Thr Leu Ser Leu His Glu Asp Glu Leu Phe 
    450                 455                 460                 


Thr Leu Thr Thr Leu Thr Thr Gly Arg Lys Gly Ser Tyr Pro Leu Pro 
465                 470                 475                 480 


Pro Lys Ser Gln Pro Phe Pro Ser Thr Tyr Lys Asp Asp Phe Asn Val 
                485                 490                 495     


Asp Tyr Pro Phe Phe Ser Glu Ala Pro Asn Phe Ala Asp Gln Thr Gly 
            500                 505                 510         


Val Phe Glu Tyr Phe Thr Asn Ile Glu Asp Pro Gly Glu His His Phe 
        515                 520                 525             


Thr Leu Arg Gln Val Leu Asn Gln Arg Pro Ile Thr Trp Ala Ala Asp 
    530                 535                 540                 


Ala Ser Asn Thr Ile Ser Ile Ile Gly Asp Tyr Asn Trp Thr Asn Leu 
545                 550                 555                 560 


Thr Ile Lys Cys Asp Val Tyr Ile Glu Thr Pro Asp Thr Gly Gly Val 
                565                 570                 575     


Phe Ile Ala Gly Arg Val Asn Lys Gly Gly Ile Leu Ile Arg Ser Ala 
            580                 585                 590         


Arg Gly Ile Phe Phe Trp Ile Phe Ala Asn Gly Ser Tyr Arg Val Thr 
        595                 600                 605             


Gly Asp Leu Ala Gly Trp Ile Ile Tyr Ala Leu Gly Arg Val Glu Val 
    610                 615                 620                 


Thr Ala Lys Lys Trp Tyr Thr Leu Thr Leu Thr Ile Lys Gly His Phe 
625                 630                 635                 640 


Thr Ser Gly Met Leu Asn Asp Lys Ser Leu Trp Thr Asp Ile Pro Val 
                645                 650                 655     


Asn Phe Pro Lys Asn Gly Trp Ala Ala Ile Gly Thr His Ser Phe Glu 
            660                 665                 670         


Phe Ala Gln Phe Asp Asn Phe Leu Val Glu Ala Thr Arg 
        675                 680                 685 


<210>  13

<211>  1530
<212>  DNA
<213>  homo sapiens

<220>
<223>  ARSA polynucleotide sequence

<400>  13
atgtccatgg gggcaccgcg gtccctcctc ctggccctgg ctgctggcct ggccgttgcc     60
cgtccgccca acatcgtgct gatctttgcc gacgacctcg gctatgggga cctgggctgc    120
tatgggcacc ccagctctac cactcccaac ctggaccagc tggcggcggg agggctgcgg    180
ttcacagact tctacgtgcc tgtgtctctg tgcacaccct ctagggccgc cctcctgacc    240
ggccggctcc cggttcggat gggcatgtac cctggcgtcc tggtgcccag ctcccggggg    300
ggcctgcccc tggaggaggt gaccgtggcc gaagtcctgg ctgcccgagg ctacctcaca    360
ggaatggccg gcaagtggca ccttggggtg gggcctgagg gggccttcct gcccccccat    420
cagggcttcc atcgatttct aggcatcccg tactcccacg accagggccc ctgccagaac    480
ctgacctgct tcccgccggc cactccttgc gacggtggct gtgaccaggg cctggtcccc    540
atcccactgt tggccaacct gtccgtggag gcgcagcccc cctggctgcc cggactagag    600
gcccgctaca tggctttcgc ccatgacctc atggccgacg cccagcgcca ggatcgcccc    660
ttcttcctgt actatgcctc tcaccacacc cactaccctc agttcagtgg gcagagcttt    720
gcagagcgtt caggccgcgg gccatttggg gactccctga tggagctgga tgcagctgtg    780
gggaccctga tgacagccat aggggacctg gggctgcttg aagagacgct ggtcatcttc    840
actgcagaca atggacctga gaccatgcgt atgtcccgag gcggctgctc cggtctcttg    900
cggtgtggaa agggaacgac ctacgagggc ggtgtccgag agcctgcctt ggccttctgg    960
ccaggtcata tcgctcccgg cgtgacccac gagctggcca gctccctgga cctgctgcct   1020
accctggcag ccctggctgg ggccccactg cccaatgtca ccttggatgg ctttgacctc   1080
agccccctgc tgctgggcac aggcaagagc cctcggcagt ctctcttctt ctacccgtcc   1140
tacccagacg aggtccgtgg ggtttttgct gtgcggactg gaaagtacaa ggctcacttc   1200
ttcacccagg gctctgccca cagtgatacc actgcagacc ctgcctgcca cgcctccagc   1260
tctctgactg ctcatgagcc cccgctgctc tatgacctgt ccaaggaccc tggtgagaac   1320
tacaacctgc tggggggtgt ggccggggcc accccagagg tgctgcaagc cctgaaacag   1380
cttcagctgc tcaaggccca gttagacgca gctgtgacct tcggccccag ccaggtggcc   1440
cggggcgagg accccgccct gcagatctgc tgtcatcctg gctgcacccc ccgcccagct   1500
tgctgccatt gcccagatcc ccatgcctga                                    1530

<210>  14

<211>  509
<212>  PRT
<213>  homo sapiens

<220>
<223>  ARSA  polypeptide sequence

<400>  14
Met Ser Met Gly Ala Pro Arg Ser Leu Leu Leu Ala Leu Ala Ala Gly 
1               5                   10                  15      


Leu Ala Val Ala Arg Pro Pro Asn Ile Val Leu Ile Phe Ala Asp Asp 
            20                  25                  30          


Leu Gly Tyr Gly Asp Leu Gly Cys Tyr Gly His Pro Ser Ser Thr Thr 
        35                  40                  45              


Pro Asn Leu Asp Gln Leu Ala Ala Gly Gly Leu Arg Phe Thr Asp Phe 
    50                  55                  60                  


Tyr Val Pro Val Ser Leu Cys Thr Pro Ser Arg Ala Ala Leu Leu Thr 
65                  70                  75                  80  


Gly Arg Leu Pro Val Arg Met Gly Met Tyr Pro Gly Val Leu Val Pro 
                85                  90                  95      


Ser Ser Arg Gly Gly Leu Pro Leu Glu Glu Val Thr Val Ala Glu Val 
            100                 105                 110         


Leu Ala Ala Arg Gly Tyr Leu Thr Gly Met Ala Gly Lys Trp His Leu 
        115                 120                 125             


Gly Val Gly Pro Glu Gly Ala Phe Leu Pro Pro His Gln Gly Phe His 
    130                 135                 140                 


Arg Phe Leu Gly Ile Pro Tyr Ser His Asp Gln Gly Pro Cys Gln Asn 
145                 150                 155                 160 


Leu Thr Cys Phe Pro Pro Ala Thr Pro Cys Asp Gly Gly Cys Asp Gln 
                165                 170                 175     


Gly Leu Val Pro Ile Pro Leu Leu Ala Asn Leu Ser Val Glu Ala Gln 
            180                 185                 190         


Pro Pro Trp Leu Pro Gly Leu Glu Ala Arg Tyr Met Ala Phe Ala His 
        195                 200                 205             


Asp Leu Met Ala Asp Ala Gln Arg Gln Asp Arg Pro Phe Phe Leu Tyr 
    210                 215                 220                 


Tyr Ala Ser His His Thr His Tyr Pro Gln Phe Ser Gly Gln Ser Phe 
225                 230                 235                 240 


Ala Glu Arg Ser Gly Arg Gly Pro Phe Gly Asp Ser Leu Met Glu Leu 
                245                 250                 255     


Asp Ala Ala Val Gly Thr Leu Met Thr Ala Ile Gly Asp Leu Gly Leu 
            260                 265                 270         


Leu Glu Glu Thr Leu Val Ile Phe Thr Ala Asp Asn Gly Pro Glu Thr 
        275                 280                 285             


Met Arg Met Ser Arg Gly Gly Cys Ser Gly Leu Leu Arg Cys Gly Lys 
    290                 295                 300                 


Gly Thr Thr Tyr Glu Gly Gly Val Arg Glu Pro Ala Leu Ala Phe Trp 
305                 310                 315                 320 


Pro Gly His Ile Ala Pro Gly Val Thr His Glu Leu Ala Ser Ser Leu 
                325                 330                 335     


Asp Leu Leu Pro Thr Leu Ala Ala Leu Ala Gly Ala Pro Leu Pro Asn 
            340                 345                 350         


Val Thr Leu Asp Gly Phe Asp Leu Ser Pro Leu Leu Leu Gly Thr Gly 
        355                 360                 365             


Lys Ser Pro Arg Gln Ser Leu Phe Phe Tyr Pro Ser Tyr Pro Asp Glu 
    370                 375                 380                 


Val Arg Gly Val Phe Ala Val Arg Thr Gly Lys Tyr Lys Ala His Phe 
385                 390                 395                 400 


Phe Thr Gln Gly Ser Ala His Ser Asp Thr Thr Ala Asp Pro Ala Cys 
                405                 410                 415     


His Ala Ser Ser Ser Leu Thr Ala His Glu Pro Pro Leu Leu Tyr Asp 
            420                 425                 430         


Leu Ser Lys Asp Pro Gly Glu Asn Tyr Asn Leu Leu Gly Gly Val Ala 
        435                 440                 445             


Gly Ala Thr Pro Glu Val Leu Gln Ala Leu Lys Gln Leu Gln Leu Leu 
    450                 455                 460                 


Lys Ala Gln Leu Asp Ala Ala Val Thr Phe Gly Pro Ser Gln Val Ala 
465                 470                 475                 480 


Arg Gly Glu Asp Pro Ala Leu Gln Ile Cys Cys His Pro Gly Cys Thr 
                485                 490                 495     


Pro Arg Pro Ala Cys Cys His Cys Pro Asp Pro His Ala 
            500                 505                 


<210>  15

<211>  1584
<212>  DNA
<213>  homo sapiens

<220>
<223>  PSAP polynucleotide sequence

<400>  15
atgtacgccc tcttcctcct ggccagcctc ctgggcgcgg ctctagccgg cccggtcctt     60
ggactgaaag aatgcaccag gggctcggca gtgtggtgcc agaatgtgaa gacggcgtcc    120
gactgcgggg cagtgaagca ctgcctgcag accgtttgga acaagccaac agtgaaatcc    180
cttccctgcg acatatgcaa agacgttgtc accgcagctg gtgatatgct gaaggacaat    240
gccactgagg aggagatcct tgtttacttg gagaagacct gtgactggct tccgaaaccg    300
aacatgtctg cttcatgcaa ggagatagtg gactcctacc tccctgtcat cctggacatc    360
attaaaggag aaatgagccg tcctggggag gtgtgctctg ctctcaacct ctgcgagtct    420
ctccagaagc acctagcaga gctgaatcac cagaagcagc tggagtccaa taagatccca    480
gagctggaca tgactgaggt ggtggccccc ttcatggcca acatccctct cctcctctac    540
cctcaggacg gcccccgcag caagccccag ccaaaggata atggggacgt ttgccaggac    600
tgcattcaga tggtgactga catccagact gctgtacgga ccaactccac ctttgtccag    660
gccttggtgg aacatgtcaa ggaggagtgt gaccgcctgg gccctggcat ggccgacata    720
tgcaagaact atatcagcca gtattctgaa attgctatcc agatgatgat gcacatgcag    780
gatcagcaac ccaaggagat ctgtgcgctg gttgggttct gtgatgaggt gaaagagatg    840
cccatgcaga ctctggtccc cgccaaagtg gcctccaaga atgtcatccc tgccctggaa    900
ctggtggagc ccattaagaa gcacgaggtc ccagcaaagt ctgatgttta ctgtgaggtg    960
tgtgaattcc tggtgaagga ggtgaccaag ctgattgaca acaacaagac tgagaaagaa   1020
atactcgacg cttttgacaa aatgtgctcg aagctgccga agtccctgtc ggaagagtgc   1080
caggaggtgg tggacacgta cggcagctcc atcctgtcca tcctgctgga ggaggtcagc   1140
cctgagctgg tgtgcagcat gctgcacctc tgctctggca cgcggctgcc tgcactgacc   1200
gttcacgtga ctcagccaaa ggacggtggc ttctgcgaag tgtgcaagaa gctggtgggt   1260
tatttggatc gcaacctgga gaaaaacagc accaagcagg agatcctggc tgctcttgag   1320
aaaggctgca gcttcctgcc agacccttac cagaagcagt gtgatcagtt tgtggcagag   1380
tacgagcccg tgctgatcga gatcctggtg gaggtgatgg atccttcctt cgtgtgcttg   1440
aaaattggag cctgcccctc ggcccataag cccttgttgg gaactgagaa gtgtatatgg   1500
ggcccaagct actggtgcca gaacacagag acagcagccc agtgcaatgc tgtcgagcat   1560
tgcaaacgcc atgtgtggaa ctag                                          1584

<210>  16

<211>  527
<212>  PRT
<213>  homo sapiens

<220>
<223>  PSAP polypeptide sequence

<400>  16
Met Tyr Ala Leu Phe Leu Leu Ala Ser Leu Leu Gly Ala Ala Leu Ala 
1               5                   10                  15      


Gly Pro Val Leu Gly Leu Lys Glu Cys Thr Arg Gly Ser Ala Val Trp 
            20                  25                  30          


Cys Gln Asn Val Lys Thr Ala Ser Asp Cys Gly Ala Val Lys His Cys 
        35                  40                  45              


Leu Gln Thr Val Trp Asn Lys Pro Thr Val Lys Ser Leu Pro Cys Asp 
    50                  55                  60                  


Ile Cys Lys Asp Val Val Thr Ala Ala Gly Asp Met Leu Lys Asp Asn 
65                  70                  75                  80  


Ala Thr Glu Glu Glu Ile Leu Val Tyr Leu Glu Lys Thr Cys Asp Trp 
                85                  90                  95      


Leu Pro Lys Pro Asn Met Ser Ala Ser Cys Lys Glu Ile Val Asp Ser 
            100                 105                 110         


Tyr Leu Pro Val Ile Leu Asp Ile Ile Lys Gly Glu Met Ser Arg Pro 
        115                 120                 125             


Gly Glu Val Cys Ser Ala Leu Asn Leu Cys Glu Ser Leu Gln Lys His 
    130                 135                 140                 


Leu Ala Glu Leu Asn His Gln Lys Gln Leu Glu Ser Asn Lys Ile Pro 
145                 150                 155                 160 


Glu Leu Asp Met Thr Glu Val Val Ala Pro Phe Met Ala Asn Ile Pro 
                165                 170                 175     


Leu Leu Leu Tyr Pro Gln Asp Gly Pro Arg Ser Lys Pro Gln Pro Lys 
            180                 185                 190         


Asp Asn Gly Asp Val Cys Gln Asp Cys Ile Gln Met Val Thr Asp Ile 
        195                 200                 205             


Gln Thr Ala Val Arg Thr Asn Ser Thr Phe Val Gln Ala Leu Val Glu 
    210                 215                 220                 


His Val Lys Glu Glu Cys Asp Arg Leu Gly Pro Gly Met Ala Asp Ile 
225                 230                 235                 240 


Cys Lys Asn Tyr Ile Ser Gln Tyr Ser Glu Ile Ala Ile Gln Met Met 
                245                 250                 255     


Met His Met Gln Asp Gln Gln Pro Lys Glu Ile Cys Ala Leu Val Gly 
            260                 265                 270         


Phe Cys Asp Glu Val Lys Glu Met Pro Met Gln Thr Leu Val Pro Ala 
        275                 280                 285             


Lys Val Ala Ser Lys Asn Val Ile Pro Ala Leu Glu Leu Val Glu Pro 
    290                 295                 300                 


Ile Lys Lys His Glu Val Pro Ala Lys Ser Asp Val Tyr Cys Glu Val 
305                 310                 315                 320 


Cys Glu Phe Leu Val Lys Glu Val Thr Lys Leu Ile Asp Asn Asn Lys 
                325                 330                 335     


Thr Glu Lys Glu Ile Leu Asp Ala Phe Asp Lys Met Cys Ser Lys Leu 
            340                 345                 350         


Pro Lys Ser Leu Ser Glu Glu Cys Gln Glu Val Val Asp Thr Tyr Gly 
        355                 360                 365             


Ser Ser Ile Leu Ser Ile Leu Leu Glu Glu Val Ser Pro Glu Leu Val 
    370                 375                 380                 


Cys Ser Met Leu His Leu Cys Ser Gly Thr Arg Leu Pro Ala Leu Thr 
385                 390                 395                 400 


Val His Val Thr Gln Pro Lys Asp Gly Gly Phe Cys Glu Val Cys Lys 
                405                 410                 415     


Lys Leu Val Gly Tyr Leu Asp Arg Asn Leu Glu Lys Asn Ser Thr Lys 
            420                 425                 430         


Gln Glu Ile Leu Ala Ala Leu Glu Lys Gly Cys Ser Phe Leu Pro Asp 
        435                 440                 445             


Pro Tyr Gln Lys Gln Cys Asp Gln Phe Val Ala Glu Tyr Glu Pro Val 
    450                 455                 460                 


Leu Ile Glu Ile Leu Val Glu Val Met Asp Pro Ser Phe Val Cys Leu 
465                 470                 475                 480 


Lys Ile Gly Ala Cys Pro Ser Ala His Lys Pro Leu Leu Gly Thr Glu 
                485                 490                 495     


Lys Cys Ile Trp Gly Pro Ser Tyr Trp Cys Gln Asn Thr Glu Thr Ala 
            500                 505                 510         


Ala Gln Cys Asn Ala Val Glu His Cys Lys Arg His Val Trp Asn 
        515                 520                 525         


<210>  17

<211>  1611
<212>  DNA
<213>  homo sapiens

<220>
<223>  GBA polynucleotide sequence

<400>  17
atggagtttt caagtccttc cagagaggaa tgtcccaagc ctttgagtag ggtaagcatc     60
atggctggca gcctcacagg attgcttcta cttcaggcag tgtcgtgggc atcaggtgcc    120
cgcccctgca tccctaaaag cttcggctac agctcggtgg tgtgtgtctg caatgccaca    180
tactgtgact cctttgaccc cccgaccttt cctgcccttg gtaccttcag ccgctatgag    240
agtacacgca gtgggcgacg gatggagctg agtatggggc ccatccaggc taatcacacg    300
ggcacaggcc tgctactgac cctgcagcca gaacagaagt tccagaaagt gaagggattt    360
ggaggggcca tgacagatgc tgctgctctc aacatccttg ccctgtcacc ccctgcccaa    420
aatttgctac ttaaatcgta cttctctgaa gaaggaatcg gatataacat catccgggta    480
cccatggcca gctgtgactt ctccatccgc acctacacct atgcagacac ccctgatgat    540
ttccagttgc acaacttcag cctcccagag gaagatacca agctcaagat acccctgatt    600
caccgagccc tgcagttggc ccagcgtccc gtttcactcc ttgccagccc ctggacatca    660
cccacttggc tcaagaccaa tggagcggtg aatgggaagg ggtcactcaa gggacagccc    720
ggagacatct accaccagac ctgggccaga tactttgtga agttcctgga tgcctatgct    780
gagcacaagt tacagttctg ggcagtgaca gctgaaaatg agccttctgc tgggctgttg    840
agtggatacc ccttccagtg cctgggcttc acccctgaac atcagcgaga cttcattgcc    900
cgtgacctag gtcctaccct cgccaacagt actcaccaca atgtccgcct actcatgctg    960
gatgaccaac gcttgctgct gccccactgg gcaaaggtgg tactgacaga cccagaagca   1020
gctaaatatg ttcatggcat tgctgtacat tggtacctgg actttctggc tccagccaaa   1080
gccaccctag gggagacaca ccgcctgttc cccaacacca tgctctttgc ctcagaggcc   1140
tgtgtgggct ccaagttctg ggagcagagt gtgcggctag gctcctggga tcgagggatg   1200
cagtacagcc acagcatcat cacgaacctc ctgtaccatg tggtcggctg gaccgactgg   1260
aaccttgccc tgaaccccga aggaggaccc aattgggtgc gtaactttgt cgacagtccc   1320
atcattgtag acatcaccaa ggacacgttt tacaaacagc ccatgttcta ccaccttggc   1380
cacttcagca agttcattcc tgagggctcc cagagagtgg ggctggttgc cagtcagaag   1440
aacgacctgg acgcagtggc actgatgcat cccgatggct ctgctgttgt ggtcgtgcta   1500
aaccgctcct ctaaggatgt gcctcttacc atcaaggatc ctgctgtggg cttcctggag   1560
acaatctcac ctggctactc cattcacacc tacctgtggc gtcgccagtg a            1611

<210>  18

<211>  536
<212>  PRT
<213>  homo sapiens

<220>
<223>  GBA polypeptide sequence

<400>  18
Met Glu Phe Ser Ser Pro Ser Arg Glu Glu Cys Pro Lys Pro Leu Ser 
1               5                   10                  15      


Arg Val Ser Ile Met Ala Gly Ser Leu Thr Gly Leu Leu Leu Leu Gln 
            20                  25                  30          


Ala Val Ser Trp Ala Ser Gly Ala Arg Pro Cys Ile Pro Lys Ser Phe 
        35                  40                  45              


Gly Tyr Ser Ser Val Val Cys Val Cys Asn Ala Thr Tyr Cys Asp Ser 
    50                  55                  60                  


Phe Asp Pro Pro Thr Phe Pro Ala Leu Gly Thr Phe Ser Arg Tyr Glu 
65                  70                  75                  80  


Ser Thr Arg Ser Gly Arg Arg Met Glu Leu Ser Met Gly Pro Ile Gln 
                85                  90                  95      


Ala Asn His Thr Gly Thr Gly Leu Leu Leu Thr Leu Gln Pro Glu Gln 
            100                 105                 110         


Lys Phe Gln Lys Val Lys Gly Phe Gly Gly Ala Met Thr Asp Ala Ala 
        115                 120                 125             


Ala Leu Asn Ile Leu Ala Leu Ser Pro Pro Ala Gln Asn Leu Leu Leu 
    130                 135                 140                 


Lys Ser Tyr Phe Ser Glu Glu Gly Ile Gly Tyr Asn Ile Ile Arg Val 
145                 150                 155                 160 


Pro Met Ala Ser Cys Asp Phe Ser Ile Arg Thr Tyr Thr Tyr Ala Asp 
                165                 170                 175     


Thr Pro Asp Asp Phe Gln Leu His Asn Phe Ser Leu Pro Glu Glu Asp 
            180                 185                 190         


Thr Lys Leu Lys Ile Pro Leu Ile His Arg Ala Leu Gln Leu Ala Gln 
        195                 200                 205             


Arg Pro Val Ser Leu Leu Ala Ser Pro Trp Thr Ser Pro Thr Trp Leu 
    210                 215                 220                 


Lys Thr Asn Gly Ala Val Asn Gly Lys Gly Ser Leu Lys Gly Gln Pro 
225                 230                 235                 240 


Gly Asp Ile Tyr His Gln Thr Trp Ala Arg Tyr Phe Val Lys Phe Leu 
                245                 250                 255     


Asp Ala Tyr Ala Glu His Lys Leu Gln Phe Trp Ala Val Thr Ala Glu 
            260                 265                 270         


Asn Glu Pro Ser Ala Gly Leu Leu Ser Gly Tyr Pro Phe Gln Cys Leu 
        275                 280                 285             


Gly Phe Thr Pro Glu His Gln Arg Asp Phe Ile Ala Arg Asp Leu Gly 
    290                 295                 300                 


Pro Thr Leu Ala Asn Ser Thr His His Asn Val Arg Leu Leu Met Leu 
305                 310                 315                 320 


Asp Asp Gln Arg Leu Leu Leu Pro His Trp Ala Lys Val Val Leu Thr 
                325                 330                 335     


Asp Pro Glu Ala Ala Lys Tyr Val His Gly Ile Ala Val His Trp Tyr 
            340                 345                 350         


Leu Asp Phe Leu Ala Pro Ala Lys Ala Thr Leu Gly Glu Thr His Arg 
        355                 360                 365             


Leu Phe Pro Asn Thr Met Leu Phe Ala Ser Glu Ala Cys Val Gly Ser 
    370                 375                 380                 


Lys Phe Trp Glu Gln Ser Val Arg Leu Gly Ser Trp Asp Arg Gly Met 
385                 390                 395                 400 


Gln Tyr Ser His Ser Ile Ile Thr Asn Leu Leu Tyr His Val Val Gly 
                405                 410                 415     


Trp Thr Asp Trp Asn Leu Ala Leu Asn Pro Glu Gly Gly Pro Asn Trp 
            420                 425                 430         


Val Arg Asn Phe Val Asp Ser Pro Ile Ile Val Asp Ile Thr Lys Asp 
        435                 440                 445             


Thr Phe Tyr Lys Gln Pro Met Phe Tyr His Leu Gly His Phe Ser Lys 
    450                 455                 460                 


Phe Ile Pro Glu Gly Ser Gln Arg Val Gly Leu Val Ala Ser Gln Lys 
465                 470                 475                 480 


Asn Asp Leu Asp Ala Val Ala Leu Met His Pro Asp Gly Ser Ala Val 
                485                 490                 495     


Val Val Val Leu Asn Arg Ser Ser Lys Asp Val Pro Leu Thr Ile Lys 
            500                 505                 510         


Asp Pro Ala Val Gly Phe Leu Glu Thr Ile Ser Pro Gly Tyr Ser Ile 
        515                 520                 525             


His Thr Tyr Leu Trp Arg Arg Gln 
    530                 535     

<210>  19

<211>  1401
<212>  DNA
<213>  homo sapiens

<220>
<223>  FUCA1 polynucleotide sequence

<400>  19
atgcgggctc cggggatgag gtcgcggccg gcgggtcccg cgctgttgct gctgctgctc     60
ttcctcggag cggccgagtc ggtgcgtcgg gcccagcctc cgcgccgcta caccccagac    120
tggccgagcc tggattctcg gccgctgccg gcctggttcg acgaagccaa gttcggggtg    180
ttcatccact ggggcgtgtt ctcggtgccc gcctggggca gcgagtggtt ctggtggcac    240
tggcagggcg aggggcggcc gcagtaccag cgcttcatgc gcgacaacta cccgcccggc    300
ttcagctacg ccgacttcgg accgcagttc actgcgcgct tcttccaccc ggaggagtgg    360
gccgacctct tccaggccgc gggcgccaag tatgtagttt tgacgacaaa gcatcacgaa    420
ggcttcacaa actggccgag tcctgtgtct tggaactgga actccaaaga cgtggggcct    480
catcgggatt tggttggtga attgggaaca gctctccgga agaggaacat ccgctatgga    540
ctataccact cactcttaga gtggttccat ccactctatc tacttgataa gaaaaatggc    600
ttcaaaacac agcattttgt cagtgcaaaa acaatgccag agctgtacga ccttgttaac    660
agctataaac ctgatctgat ctggtctgat ggggagtggg aatgtcctga tacttactgg    720
aactccacaa attttctttc atggctctac aatgacagcc ctgtcaagga tgaggtggta    780
gtaaatgacc gatggggtca gaactgttcc tgtcaccatg gaggatacta taactgtgaa    840
gataaattca agccacagag cttgccagat cacaagtggg agatgtgcac cagcattgac    900
aagttttcct ggggctatcg tcgtgacatg gcattgtctg atgttacaga agaatctgaa    960
atcatttcgg aactggttca gacagtaagt ttgggaggca actatcttct gaacattgga   1020
ccaactaaag atggactgat tgttcccatc ttccaagaaa ggcttcttgc tgttgggaaa   1080
tggctgagca tcaatgggga ggctatctat gcctccaaac catggcgggt gcaatgggaa   1140
aagaacacaa catctgtatg gtatacctca aagggatcgg ctgtttatgc catttttctg   1200
cactggccag aaaatggagt cttaaacctt gaatccccca taactacctc aactacaaag   1260
ataacaatgc tgggaattca aggagatctg aagtggtcca cagatccaga taaaggtctc   1320
ttcatctctc taccccagtt gccaccctct gctgtccccg cagagtttgc ttggactata   1380
aagctgacag gagtgaagta a                                             1401


<210>  20

<211>  466
<212>  PRT
<213>  homo sapiens

<220>
<223>  FUCA1 polypeptide sequence

<400>  20
Met Arg Ala Pro Gly Met Arg Ser Arg Pro Ala Gly Pro Ala Leu Leu 
1               5                   10                  15      


Leu Leu Leu Leu Phe Leu Gly Ala Ala Glu Ser Val Arg Arg Ala Gln 
            20                  25                  30          


Pro Pro Arg Arg Tyr Thr Pro Asp Trp Pro Ser Leu Asp Ser Arg Pro 
        35                  40                  45              


Leu Pro Ala Trp Phe Asp Glu Ala Lys Phe Gly Val Phe Ile His Trp 
    50                  55                  60                  


Gly Val Phe Ser Val Pro Ala Trp Gly Ser Glu Trp Phe Trp Trp His 
65                  70                  75                  80  


Trp Gln Gly Glu Gly Arg Pro Gln Tyr Gln Arg Phe Met Arg Asp Asn 
                85                  90                  95      


Tyr Pro Pro Gly Phe Ser Tyr Ala Asp Phe Gly Pro Gln Phe Thr Ala 
            100                 105                 110         


Arg Phe Phe His Pro Glu Glu Trp Ala Asp Leu Phe Gln Ala Ala Gly 
        115                 120                 125             


Ala Lys Tyr Val Val Leu Thr Thr Lys His His Glu Gly Phe Thr Asn 
    130                 135                 140                 


Trp Pro Ser Pro Val Ser Trp Asn Trp Asn Ser Lys Asp Val Gly Pro 
145                 150                 155                 160 


His Arg Asp Leu Val Gly Glu Leu Gly Thr Ala Leu Arg Lys Arg Asn 
                165                 170                 175     


Ile Arg Tyr Gly Leu Tyr His Ser Leu Leu Glu Trp Phe His Pro Leu 
            180                 185                 190         


Tyr Leu Leu Asp Lys Lys Asn Gly Phe Lys Thr Gln His Phe Val Ser 
        195                 200                 205             


Ala Lys Thr Met Pro Glu Leu Tyr Asp Leu Val Asn Ser Tyr Lys Pro 
    210                 215                 220                 


Asp Leu Ile Trp Ser Asp Gly Glu Trp Glu Cys Pro Asp Thr Tyr Trp 
225                 230                 235                 240 


Asn Ser Thr Asn Phe Leu Ser Trp Leu Tyr Asn Asp Ser Pro Val Lys 
                245                 250                 255     


Asp Glu Val Val Val Asn Asp Arg Trp Gly Gln Asn Cys Ser Cys His 
            260                 265                 270         


His Gly Gly Tyr Tyr Asn Cys Glu Asp Lys Phe Lys Pro Gln Ser Leu 
        275                 280                 285             


Pro Asp His Lys Trp Glu Met Cys Thr Ser Ile Asp Lys Phe Ser Trp 
    290                 295                 300                 


Gly Tyr Arg Arg Asp Met Ala Leu Ser Asp Val Thr Glu Glu Ser Glu 
305                 310                 315                 320 


Ile Ile Ser Glu Leu Val Gln Thr Val Ser Leu Gly Gly Asn Tyr Leu 
                325                 330                 335     


Leu Asn Ile Gly Pro Thr Lys Asp Gly Leu Ile Val Pro Ile Phe Gln 
            340                 345                 350         


Glu Arg Leu Leu Ala Val Gly Lys Trp Leu Ser Ile Asn Gly Glu Ala 
        355                 360                 365             


Ile Tyr Ala Ser Lys Pro Trp Arg Val Gln Trp Glu Lys Asn Thr Thr 
    370                 375                 380                 


Ser Val Trp Tyr Thr Ser Lys Gly Ser Ala Val Tyr Ala Ile Phe Leu 
385                 390                 395                 400 


His Trp Pro Glu Asn Gly Val Leu Asn Leu Glu Ser Pro Ile Thr Thr 
                405                 410                 415     


Ser Thr Thr Lys Ile Thr Met Leu Gly Ile Gln Gly Asp Leu Lys Trp 
            420                 425                 430         


Ser Thr Asp Pro Asp Lys Gly Leu Phe Ile Ser Leu Pro Gln Leu Pro 
        435                 440                 445             


Pro Ser Ala Val Pro Ala Glu Phe Ala Trp Thr Ile Lys Leu Thr Gly 
    450                 455                 460                 


Val Lys 
465     

<210>  21

<211>  3036
<212>  DNA
<213>  homo sapiens

<220>
<223>  MAN2B1 polynucleotide sequence

<400>  21
atgggcgcct acgcgcgggc ttcgggggtc tgcgctcgcg gctgcctgga ctcagcaggc     60
ccctggacca tgtcccgcgc cctgcggcca ccgctcccgc ctctctgctt tttccttttg    120
ttgctggcgg ctgccggtgc tcgggccggg ggatacgaga catgccccac agtgcagccg    180
aacatgctga acgtgcacct gctgcctcac acacatgatg acgtgggctg gctcaaaacc    240
gtggaccagt acttttatgg aatcaagaat gacatccagc acgccggtgt gcagtacatc    300
ctggactcgg tcatctctgc cttgctggca gatcccaccc gtcgcttcat ttacgtggag    360
attgccttct tctcccgttg gtggcaccag cagacaaatg ccacacagga agtcgtgcga    420
gaccttgtgc gccaggggcg cctggagttc gccaatggtg gctgggtgat gaacgatgag    480
gcagccaccc actacggtgc catcgtggac cagatgacac ttgggctgcg ctttctggag    540
gacacatttg gcaatgatgg gcgaccccgt gtggcctggc acattgaccc cttcggccac    600
tctcgggagc aggcctcgct gtttgcgcag atgggcttcg acggcttctt ctttgggcgc    660
cttgattatc aagataagtg ggtacggatg cagaagctgg agatggagca ggtgtggcgg    720
gccagcacca gcctgaagcc cccgaccgcg gacctcttca ctggtgtgct tcccaatggt    780
tacaacccgc caaggaatct gtgctgggat gtgctgtgtg tcgatcagcc gctggtggag    840
gaccctcgca gccccgagta caacgccaag gagctggtcg attacttcct aaatgtggcc    900
actgcccagg gccggtatta ccgcaccaac cacactgtga tgaccatggg ctcggacttc    960
caatatgaga atgccaacat gtggttcaag aaccttgaca agctcatccg gctggtaaat   1020
gcgcagcagg caaaaggaag cagtgtccat gttctctact ccacccccgc ttgttacctc   1080
tgggagctga acaaggccaa cctcacctgg tcagtgaaac atgacgactt cttcccttac   1140
gcggatggcc cccaccagtt ctggaccggt tacttttcca gtcggccggc cctcaaacgc   1200
tacgagcgcc tcagctacaa cttcctgcag gtgtgcaacc agctggaggc gctggtgggc   1260
ctggcggcca acgtgggacc ctatggctcc ggagacagtg cacccctcaa tgaggcgatg   1320
gctgtgctcc agcatcacga cgccgtcagc ggcacctccc gccagcacgt ggccaacgac   1380
tacgcgcgcc agcttgcggc aggctggggg ccttgcgagg ttcttctgag caacgcgctg   1440
gcgcggctca gaggcttcaa agatcacttc accttttgcc aacagctaaa catcagcatc   1500
tgcccgctca gccagacggc ggcgcgcttc caggtcatcg tttataatcc cctggggcgg   1560
aaggtgaatt ggatggtacg gctgccggtc agcgaaggcg ttttcgttgt gaaggacccc   1620
aatggcagga cagtgcccag cgatgtggta atatttccca gctcagacag ccaggcgcac   1680
cctccggagc tgctgttctc agcctcactg cccgccctgg gcttcagcac ctattcagta   1740
gcccaggtgc ctcgctggaa gccccaggcc cgcgcaccac agcccatccc cagaagatcc   1800
tggtcccctg ctttaaccat cgaaaatgag cacatccggg caacgtttga tcctgacaca   1860
gggctgttga tggagattat gaacatgaat cagcaactcc tgctgcctgt tcgccagacc   1920
ttcttctggt acaacgccag tataggtgac aacgaaagtg accaggcctc aggtgcctac   1980
atcttcagac ccaaccaaca gaaaccgctg cctgtgagcc gctgggctca gatccacctg   2040
gtgaagacac ccttggtgca ggaggtgcac cagaacttct cagcttggtg ttcccaggtg   2100
gttcgcctgt acccaggaca gcggcacctg gagctagagt ggtcggtggg gccgatacct   2160
gtgggcgaca cctgggggaa ggaggtcatc agccgttttg acacaccgct ggagacaaag   2220
ggacgcttct acacagacag caatggccgg gagatcctgg agaggaggcg ggattatcga   2280
cccacctgga aactgaacca gacggagccc gtggcaggaa actactatcc agtcaacacc   2340
cggatttaca tcacggatgg aaacatgcag ctgactgtgc tgactgaccg ctcccagggg   2400
ggcagcagcc tgagagatgg ctcgctggag ctcatggtgc accgaaggct gctgaaggac   2460
gatggacgcg gagtatcgga gccactaatg gagaacgggt cgggggcgtg ggtgcgaggg   2520
cgccacctgg tgctgctgga cacagcccag gctgcagccg ccggacaccg gctcctggcg   2580
gagcaggagg tcctggcccc tcaggtggtg ctggccccgg gtggcggcgc cgcctacaat   2640
ctcggggctc ctccgcgcac gcagttctca gggctgcgca gggacctgcc gccctcggtg   2700
cacctgctca cgctggccag ctggggcccc gaaatggtgc tgctgcgctt ggagcaccag   2760
tttgccgtag gagaggattc cggacgtaac ctgagcgccc ccgttacctt gaacttgagg   2820
gacctgttct ccaccttcac catcacccgc ctgcaggaga ccacgctggt ggccaaccag   2880
ctccgcgagg cagcctccag gctcaagtgg acaacaaaca caggccccac accccaccaa   2940
actccgtacc agctggaccc ggccaacatc acgctggaac ccatggaaat ccgcactttc   3000
ctggcctcag ttcaatggaa ggaggtggat ggttag                             3036


<210>  22

<211>  1011
<212>  PRT
<213>  homo sapiens

<220>
<223>  MAN2B1 polypeptide sequence

<400>  22
Met Gly Ala Tyr Ala Arg Ala Ser Gly Val Cys Ala Arg Gly Cys Leu 
1               5                   10                  15      


Asp Ser Ala Gly Pro Trp Thr Met Ser Arg Ala Leu Arg Pro Pro Leu 
            20                  25                  30          


Pro Pro Leu Cys Phe Phe Leu Leu Leu Leu Ala Ala Ala Gly Ala Arg 
        35                  40                  45              


Ala Gly Gly Tyr Glu Thr Cys Pro Thr Val Gln Pro Asn Met Leu Asn 
    50                  55                  60                  


Val His Leu Leu Pro His Thr His Asp Asp Val Gly Trp Leu Lys Thr 
65                  70                  75                  80  


Val Asp Gln Tyr Phe Tyr Gly Ile Lys Asn Asp Ile Gln His Ala Gly 
                85                  90                  95      


Val Gln Tyr Ile Leu Asp Ser Val Ile Ser Ala Leu Leu Ala Asp Pro 
            100                 105                 110         


Thr Arg Arg Phe Ile Tyr Val Glu Ile Ala Phe Phe Ser Arg Trp Trp 
        115                 120                 125             


His Gln Gln Thr Asn Ala Thr Gln Glu Val Val Arg Asp Leu Val Arg 
    130                 135                 140                 


Gln Gly Arg Leu Glu Phe Ala Asn Gly Gly Trp Val Met Asn Asp Glu 
145                 150                 155                 160 


Ala Ala Thr His Tyr Gly Ala Ile Val Asp Gln Met Thr Leu Gly Leu 
                165                 170                 175     


Arg Phe Leu Glu Asp Thr Phe Gly Asn Asp Gly Arg Pro Arg Val Ala 
            180                 185                 190         


Trp His Ile Asp Pro Phe Gly His Ser Arg Glu Gln Ala Ser Leu Phe 
        195                 200                 205             


Ala Gln Met Gly Phe Asp Gly Phe Phe Phe Gly Arg Leu Asp Tyr Gln 
    210                 215                 220                 


Asp Lys Trp Val Arg Met Gln Lys Leu Glu Met Glu Gln Val Trp Arg 
225                 230                 235                 240 


Ala Ser Thr Ser Leu Lys Pro Pro Thr Ala Asp Leu Phe Thr Gly Val 
                245                 250                 255     


Leu Pro Asn Gly Tyr Asn Pro Pro Arg Asn Leu Cys Trp Asp Val Leu 
            260                 265                 270         


Cys Val Asp Gln Pro Leu Val Glu Asp Pro Arg Ser Pro Glu Tyr Asn 
        275                 280                 285             


Ala Lys Glu Leu Val Asp Tyr Phe Leu Asn Val Ala Thr Ala Gln Gly 
    290                 295                 300                 


Arg Tyr Tyr Arg Thr Asn His Thr Val Met Thr Met Gly Ser Asp Phe 
305                 310                 315                 320 


Gln Tyr Glu Asn Ala Asn Met Trp Phe Lys Asn Leu Asp Lys Leu Ile 
                325                 330                 335     


Arg Leu Val Asn Ala Gln Gln Ala Lys Gly Ser Ser Val His Val Leu 
            340                 345                 350         


Tyr Ser Thr Pro Ala Cys Tyr Leu Trp Glu Leu Asn Lys Ala Asn Leu 
        355                 360                 365             


Thr Trp Ser Val Lys His Asp Asp Phe Phe Pro Tyr Ala Asp Gly Pro 
    370                 375                 380                 


His Gln Phe Trp Thr Gly Tyr Phe Ser Ser Arg Pro Ala Leu Lys Arg 
385                 390                 395                 400 


Tyr Glu Arg Leu Ser Tyr Asn Phe Leu Gln Val Cys Asn Gln Leu Glu 
                405                 410                 415     


Ala Leu Val Gly Leu Ala Ala Asn Val Gly Pro Tyr Gly Ser Gly Asp 
            420                 425                 430         


Ser Ala Pro Leu Asn Glu Ala Met Ala Val Leu Gln His His Asp Ala 
        435                 440                 445             


Val Ser Gly Thr Ser Arg Gln His Val Ala Asn Asp Tyr Ala Arg Gln 
    450                 455                 460                 


Leu Ala Ala Gly Trp Gly Pro Cys Glu Val Leu Leu Ser Asn Ala Leu 
465                 470                 475                 480 


Ala Arg Leu Arg Gly Phe Lys Asp His Phe Thr Phe Cys Gln Gln Leu 
                485                 490                 495     


Asn Ile Ser Ile Cys Pro Leu Ser Gln Thr Ala Ala Arg Phe Gln Val 
            500                 505                 510         


Ile Val Tyr Asn Pro Leu Gly Arg Lys Val Asn Trp Met Val Arg Leu 
        515                 520                 525             


Pro Val Ser Glu Gly Val Phe Val Val Lys Asp Pro Asn Gly Arg Thr 
    530                 535                 540                 


Val Pro Ser Asp Val Val Ile Phe Pro Ser Ser Asp Ser Gln Ala His 
545                 550                 555                 560 


Pro Pro Glu Leu Leu Phe Ser Ala Ser Leu Pro Ala Leu Gly Phe Ser 
                565                 570                 575     


Thr Tyr Ser Val Ala Gln Val Pro Arg Trp Lys Pro Gln Ala Arg Ala 
            580                 585                 590         


Pro Gln Pro Ile Pro Arg Arg Ser Trp Ser Pro Ala Leu Thr Ile Glu 
        595                 600                 605             


Asn Glu His Ile Arg Ala Thr Phe Asp Pro Asp Thr Gly Leu Leu Met 
    610                 615                 620                 


Glu Ile Met Asn Met Asn Gln Gln Leu Leu Leu Pro Val Arg Gln Thr 
625                 630                 635                 640 


Phe Phe Trp Tyr Asn Ala Ser Ile Gly Asp Asn Glu Ser Asp Gln Ala 
                645                 650                 655     


Ser Gly Ala Tyr Ile Phe Arg Pro Asn Gln Gln Lys Pro Leu Pro Val 
            660                 665                 670         


Ser Arg Trp Ala Gln Ile His Leu Val Lys Thr Pro Leu Val Gln Glu 
        675                 680                 685             


Val His Gln Asn Phe Ser Ala Trp Cys Ser Gln Val Val Arg Leu Tyr 
    690                 695                 700                 


Pro Gly Gln Arg His Leu Glu Leu Glu Trp Ser Val Gly Pro Ile Pro 
705                 710                 715                 720 


Val Gly Asp Thr Trp Gly Lys Glu Val Ile Ser Arg Phe Asp Thr Pro 
                725                 730                 735     


Leu Glu Thr Lys Gly Arg Phe Tyr Thr Asp Ser Asn Gly Arg Glu Ile 
            740                 745                 750         


Leu Glu Arg Arg Arg Asp Tyr Arg Pro Thr Trp Lys Leu Asn Gln Thr 
        755                 760                 765             


Glu Pro Val Ala Gly Asn Tyr Tyr Pro Val Asn Thr Arg Ile Tyr Ile 
    770                 775                 780                 


Thr Asp Gly Asn Met Gln Leu Thr Val Leu Thr Asp Arg Ser Gln Gly 
785                 790                 795                 800 


Gly Ser Ser Leu Arg Asp Gly Ser Leu Glu Leu Met Val His Arg Arg 
                805                 810                 815     


Leu Leu Lys Asp Asp Gly Arg Gly Val Ser Glu Pro Leu Met Glu Asn 
            820                 825                 830         


Gly Ser Gly Ala Trp Val Arg Gly Arg His Leu Val Leu Leu Asp Thr 
        835                 840                 845             


Ala Gln Ala Ala Ala Ala Gly His Arg Leu Leu Ala Glu Gln Glu Val 
    850                 855                 860                 


Leu Ala Pro Gln Val Val Leu Ala Pro Gly Gly Gly Ala Ala Tyr Asn 
865                 870                 875                 880 


Leu Gly Ala Pro Pro Arg Thr Gln Phe Ser Gly Leu Arg Arg Asp Leu 
                885                 890                 895     


Pro Pro Ser Val His Leu Leu Thr Leu Ala Ser Trp Gly Pro Glu Met 
            900                 905                 910         


Val Leu Leu Arg Leu Glu His Gln Phe Ala Val Gly Glu Asp Ser Gly 
        915                 920                 925             


Arg Asn Leu Ser Ala Pro Val Thr Leu Asn Leu Arg Asp Leu Phe Ser 
    930                 935                 940                 


Thr Phe Thr Ile Thr Arg Leu Gln Glu Thr Thr Leu Val Ala Asn Gln 
945                 950                 955                 960 


Leu Arg Glu Ala Ala Ser Arg Leu Lys Trp Thr Thr Asn Thr Gly Pro 
                965                 970                 975     


Thr Pro His Gln Thr Pro Tyr Gln Leu Asp Pro Ala Asn Ile Thr Leu 
            980                 985                 990         


Glu Pro Met Glu Ile Arg Thr Phe Leu Ala Ser Val Gln Trp Lys Glu 
        995                 1000                1005            


Val Asp Gly 
    1010    

<210>  23

<211>  1041
<212>  DNA
<213>  homo sapiens

<220>
<223>  AGA polynucleotide sequence

<400>  23
atggcgcgga agtcgaactt gcctgtgctt ctcgtgccgt ttctgctctg ccaggcccta     60
gtgcgctgct ccagccctct gcccctggtc gtcaacactt ggccctttaa gaatgcaacc    120
gaagcagcgt ggagggcatt agcatctgga ggctctgccc tggatgcagt ggagagcggc    180
tgtgccatgt gtgagagaga gcagtgtgac ggctctgtag gctttggagg aagtcctgat    240
gaacttggag aaaccacact agatgccatg atcatggatg gcactactat ggatgtagga    300
gcagtaggag atctcagacg aattaaaaat gctattggtg tggcacggaa agtactggaa    360
catacaacac acacactttt agtaggagag tcagccacca catttgctca aagtatgggg    420
tttatcaatg aagacttatc taccactgct tctcaagctc ttcattcaga ttggcttgct    480
cggaattgcc agccaaatta ttggaggaat gttataccag atccctcaaa atactgcgga    540
ccctacaaac cacctggtat cttaaagcag gatattccta tccataaaga aacagaagat    600
gatcgtggtc atgacactat tggcatggtt gtaatccata agacaggaca tattgctgct    660
ggtacatcta caaatggtat aaaattcaaa atacatggcc gtgtaggaga ctcaccaata    720
cctggagctg gagcctatgc tgacgatact gcaggggcag ccgcagccac tgggaatggt    780
gatatattga tgcgcttcct gccaagctac caagctgtag aatacatgag aagaggagaa    840
gatccaacca tagcttgcca aaaagtgatt tcaagaatcc agaagcattt tccagaattc    900
tttggggctg ttatatgtgc caatgtgact ggaagttacg gtgctgcttg caataaactt    960
tcaacattta ctcagtttag tttcatggtt tataattccg aaaaaaatca gccaactgag   1020
gaaaaagtgg actgcatcta a                                             1041

<210>  24

<211>  346
<212>  PRT
<213>  homo sapiens

<220>
<223>  AGA polypeptide sequence

<400>  24
Met Ala Arg Lys Ser Asn Leu Pro Val Leu Leu Val Pro Phe Leu Leu 
1               5                   10                  15      


Cys Gln Ala Leu Val Arg Cys Ser Ser Pro Leu Pro Leu Val Val Asn 
            20                  25                  30          


Thr Trp Pro Phe Lys Asn Ala Thr Glu Ala Ala Trp Arg Ala Leu Ala 
        35                  40                  45              


Ser Gly Gly Ser Ala Leu Asp Ala Val Glu Ser Gly Cys Ala Met Cys 
    50                  55                  60                  


Glu Arg Glu Gln Cys Asp Gly Ser Val Gly Phe Gly Gly Ser Pro Asp 
65                  70                  75                  80  


Glu Leu Gly Glu Thr Thr Leu Asp Ala Met Ile Met Asp Gly Thr Thr 
                85                  90                  95      


Met Asp Val Gly Ala Val Gly Asp Leu Arg Arg Ile Lys Asn Ala Ile 
            100                 105                 110         


Gly Val Ala Arg Lys Val Leu Glu His Thr Thr His Thr Leu Leu Val 
        115                 120                 125             


Gly Glu Ser Ala Thr Thr Phe Ala Gln Ser Met Gly Phe Ile Asn Glu 
    130                 135                 140                 


Asp Leu Ser Thr Thr Ala Ser Gln Ala Leu His Ser Asp Trp Leu Ala 
145                 150                 155                 160 


Arg Asn Cys Gln Pro Asn Tyr Trp Arg Asn Val Ile Pro Asp Pro Ser 
                165                 170                 175     


Lys Tyr Cys Gly Pro Tyr Lys Pro Pro Gly Ile Leu Lys Gln Asp Ile 
            180                 185                 190         


Pro Ile His Lys Glu Thr Glu Asp Asp Arg Gly His Asp Thr Ile Gly 
        195                 200                 205             


Met Val Val Ile His Lys Thr Gly His Ile Ala Ala Gly Thr Ser Thr 
    210                 215                 220                 


Asn Gly Ile Lys Phe Lys Ile His Gly Arg Val Gly Asp Ser Pro Ile 
225                 230                 235                 240 


Pro Gly Ala Gly Ala Tyr Ala Asp Asp Thr Ala Gly Ala Ala Ala Ala 
                245                 250                 255     


Thr Gly Asn Gly Asp Ile Leu Met Arg Phe Leu Pro Ser Tyr Gln Ala 
            260                 265                 270         


Val Glu Tyr Met Arg Arg Gly Glu Asp Pro Thr Ile Ala Cys Gln Lys 
        275                 280                 285             


Val Ile Ser Arg Ile Gln Lys His Phe Pro Glu Phe Phe Gly Ala Val 
    290                 295                 300                 


Ile Cys Ala Asn Val Thr Gly Ser Tyr Gly Ala Ala Cys Asn Lys Leu 
305                 310                 315                 320 


Ser Thr Phe Thr Gln Phe Ser Phe Met Val Tyr Asn Ser Glu Lys Asn 
                325                 330                 335     


Gln Pro Thr Glu Glu Lys Val Asp Cys Ile 
            340                 345     


<210>  25

<211>  1236
<212>  DNA
<213>  homo sapiens

<220>
<223>  ASAH1 polynucleotide sequence

<400>  25
atgaactgct gcatcgggct gggagagaaa gctcgcgggt cccaccgggc ctcctaccca     60
agtctcagcg cgcttttcac cgaggcctca attctgggat ttggcagctt tgctgtgaaa    120
gcccaatgga cagaggactg cagaaaatca acctatcctc cttcaggacc aacgtacaga    180
ggtgcagttc catggtacac cataaatctt gacttaccac cctacaaaag atggcatgaa    240
ttgatgcttg acaaggcacc agtgctaaag gttatagtga attctctgaa gaatatgata    300
aatacattcg tgccaagtgg aaaaattatg caggtggtgg atgaaaaatt gcctggccta    360
cttggcaact ttcctggccc ttttgaagag gaaatgaagg gtattgccgc tgttactgat    420
atacctttag gagagattat ttcattcaat attttttatg aattatttac catttgtact    480
tcaatagtag cagaagacaa aaaaggtcat ctaatacatg ggagaaacat ggattttgga    540
gtatttcttg ggtggaacat aaataatgat acctgggtca taactgagca actaaaacct    600
ttaacagtga atttggattt ccaaagaaac aacaaaactg tcttcaaggc ttcaagcttt    660
gctggctatg tgggcatgtt aacaggattc aaaccaggac tgttcagtct tacactgaat    720
gaacgtttca gtataaatgg tggttatctg ggtattctag aatggattct gggaaagaaa    780
gatgtcatgt ggatagggtt cctcactaga acagttctgg aaaatagcac aagttatgaa    840
gaagccaaga atttattgac caagaccaag atattggccc cagcctactt tatcctggga    900
ggcaaccagt ctggggaagg ttgtgtgatt acacgagaca gaaaggaatc attggatgta    960
tatgaactcg atgctaagca gggtagatgg tatgtggtac aaacaaatta tgaccgttgg   1020
aaacatccct tcttccttga tgatcgcaga acgcctgcaa agatgtgtct gaaccgcacc   1080
agccaagaga atatctcatt tgaaaccatg tatgatgtcc tgtcaacaaa acctgtcctc   1140
aacaagctga ccgtatacac aaccttgata gatgttacca aaggtcaatt cgaaacttac   1200
ctgcgggact gccctgaccc ttgtataggt tggtga                             1236

<210>  26

<211>  411
<212>  PRT
<213>  homo sapiens

<220>
<223>  ASAH1 polypeptide sequence

<400>  26
Met Asn Cys Cys Ile Gly Leu Gly Glu Lys Ala Arg Gly Ser His Arg 
1               5                   10                  15      


Ala Ser Tyr Pro Ser Leu Ser Ala Leu Phe Thr Glu Ala Ser Ile Leu 
            20                  25                  30          


Gly Phe Gly Ser Phe Ala Val Lys Ala Gln Trp Thr Glu Asp Cys Arg 
        35                  40                  45              


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
    50                  55                  60                  


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
65                  70                  75                  80  


Leu Met Leu Asp Lys Ala Pro Val Leu Lys Val Ile Val Asn Ser Leu 
                85                  90                  95      


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Ile Met Gln Val 
            100                 105                 110         


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
        115                 120                 125             


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
    130                 135                 140                 


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
145                 150                 155                 160 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
                165                 170                 175     


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
            180                 185                 190         


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
        195                 200                 205             


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
    210                 215                 220                 


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
225                 230                 235                 240 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
                245                 250                 255     


Leu Gly Lys Lys Asp Val Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
            260                 265                 270         


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
        275                 280                 285             


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
    290                 295                 300                 


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
305                 310                 315                 320 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
                325                 330                 335     


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
            340                 345                 350         


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
        355                 360                 365             


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
    370                 375                 380                 


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
385                 390                 395                 400 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
                405                 410     

<210>  27

<211>  1590
<212>  DNA
<213>  homo sapiens

<220>
<223>  HEXA polynucleotide sequence

<400>  27
atgacaagct ccaggctttg gttttcgctg ctgctggcgg cagcgttcgc aggacgggcg     60
acggccctct ggccctggcc tcagaacttc caaacctccg accagcgcta cgtcctttac    120
ccgaacaact ttcaattcca gtacgatgtc agctcggccg cgcagcccgg ctgctcagtc    180
ctcgacgagg ccttccagcg ctatcgtgac ctgcttttcg gttccgggtc ttggccccgt    240
ccttacctca cagggaaacg gcatacactg gagaagaatg tgttggttgt ctctgtagtc    300
acacctggat gtaaccagct tcctactttg gagtcagtgg agaattatac cctgaccata    360
aatgatgacc agtgtttact cctctctgag actgtctggg gagctctccg aggtctggag    420
acttttagcc agcttgtttg gaaatctgct gagggcacat tctttatcaa caagactgag    480
attgaggact ttccccgctt tcctcaccgg ggcttgctgt tggatacatc tcgccattac    540
ctgccactct ctagcatcct ggacactctg gatgtcatgg cgtacaataa attgaacgtg    600
ttccactggc atctggtaga tgatccttcc ttcccatatg agagcttcac ttttccagag    660
ctcatgagaa aggggtccta caaccctgtc acccacatct acacagcaca ggatgtgaag    720
gaggtcattg aatacgcacg gctccggggt atccgtgtgc ttgcagagtt tgacactcct    780
ggccacactt tgtcctgggg accaggtatc cctggattac tgactccttg ctactctggg    840
tctgagccct ctggcacctt tggaccagtg aatcccagtc tcaataatac ctatgagttc    900
atgagcacat tcttcttaga agtcagctct gtcttcccag atttttatct tcatcttgga    960
ggagatgagg ttgatttcac ctgctggaag tccaacccag agatccagga ctttatgagg   1020
aagaaaggct tcggtgagga cttcaagcag ctggagtcct tctacatcca gacgctgctg   1080
gacatcgtct cttcttatgg caagggctat gtggtgtggc aggaggtgtt tgataataaa   1140
gtaaagattc agccagacac aatcatacag gtgtggcgag aggatattcc agtgaactat   1200
atgaaggagc tggaactggt caccaaggcc ggcttccggg cccttctctc tgccccctgg   1260
tacctgaacc gtatatccta tggccctgac tggaaggatt tctacatagt ggaacccctg   1320
gcatttgaag gtacccctga gcagaaggct ctggtgattg gtggagaggc ttgtatgtgg   1380
ggagaatatg tggacaacac aaacctggtc cccaggctct ggcccagagc aggggctgtt   1440
gccgaaaggc tgtggagcaa caagttgaca tctgacctga catttgccta tgaacgtttg   1500
tcacacttcc gctgtgaatt gctgaggcga ggtgtccagg cccaacccct caatgtaggc   1560
ttctgtgagc aggagtttga acagacctga                                    1590

<210>  28

<211>  529
<212>  PRT
<213>  homo sapiens

<220>
<223>  HEXA polypeptide sequence

<400>  28
Met Thr Ser Ser Arg Leu Trp Phe Ser Leu Leu Leu Ala Ala Ala Phe 
1               5                   10                  15      


Ala Gly Arg Ala Thr Ala Leu Trp Pro Trp Pro Gln Asn Phe Gln Thr 
            20                  25                  30          


Ser Asp Gln Arg Tyr Val Leu Tyr Pro Asn Asn Phe Gln Phe Gln Tyr 
        35                  40                  45              


Asp Val Ser Ser Ala Ala Gln Pro Gly Cys Ser Val Leu Asp Glu Ala 
    50                  55                  60                  


Phe Gln Arg Tyr Arg Asp Leu Leu Phe Gly Ser Gly Ser Trp Pro Arg 
65                  70                  75                  80  


Pro Tyr Leu Thr Gly Lys Arg His Thr Leu Glu Lys Asn Val Leu Val 
                85                  90                  95      


Val Ser Val Val Thr Pro Gly Cys Asn Gln Leu Pro Thr Leu Glu Ser 
            100                 105                 110         


Val Glu Asn Tyr Thr Leu Thr Ile Asn Asp Asp Gln Cys Leu Leu Leu 
        115                 120                 125             


Ser Glu Thr Val Trp Gly Ala Leu Arg Gly Leu Glu Thr Phe Ser Gln 
    130                 135                 140                 


Leu Val Trp Lys Ser Ala Glu Gly Thr Phe Phe Ile Asn Lys Thr Glu 
145                 150                 155                 160 


Ile Glu Asp Phe Pro Arg Phe Pro His Arg Gly Leu Leu Leu Asp Thr 
                165                 170                 175     


Ser Arg His Tyr Leu Pro Leu Ser Ser Ile Leu Asp Thr Leu Asp Val 
            180                 185                 190         


Met Ala Tyr Asn Lys Leu Asn Val Phe His Trp His Leu Val Asp Asp 
        195                 200                 205             


Pro Ser Phe Pro Tyr Glu Ser Phe Thr Phe Pro Glu Leu Met Arg Lys 
    210                 215                 220                 


Gly Ser Tyr Asn Pro Val Thr His Ile Tyr Thr Ala Gln Asp Val Lys 
225                 230                 235                 240 


Glu Val Ile Glu Tyr Ala Arg Leu Arg Gly Ile Arg Val Leu Ala Glu 
                245                 250                 255     


Phe Asp Thr Pro Gly His Thr Leu Ser Trp Gly Pro Gly Ile Pro Gly 
            260                 265                 270         


Leu Leu Thr Pro Cys Tyr Ser Gly Ser Glu Pro Ser Gly Thr Phe Gly 
        275                 280                 285             


Pro Val Asn Pro Ser Leu Asn Asn Thr Tyr Glu Phe Met Ser Thr Phe 
    290                 295                 300                 


Phe Leu Glu Val Ser Ser Val Phe Pro Asp Phe Tyr Leu His Leu Gly 
305                 310                 315                 320 


Gly Asp Glu Val Asp Phe Thr Cys Trp Lys Ser Asn Pro Glu Ile Gln 
                325                 330                 335     


Asp Phe Met Arg Lys Lys Gly Phe Gly Glu Asp Phe Lys Gln Leu Glu 
            340                 345                 350         


Ser Phe Tyr Ile Gln Thr Leu Leu Asp Ile Val Ser Ser Tyr Gly Lys 
        355                 360                 365             


Gly Tyr Val Val Trp Gln Glu Val Phe Asp Asn Lys Val Lys Ile Gln 
    370                 375                 380                 


Pro Asp Thr Ile Ile Gln Val Trp Arg Glu Asp Ile Pro Val Asn Tyr 
385                 390                 395                 400 


Met Lys Glu Leu Glu Leu Val Thr Lys Ala Gly Phe Arg Ala Leu Leu 
                405                 410                 415     


Ser Ala Pro Trp Tyr Leu Asn Arg Ile Ser Tyr Gly Pro Asp Trp Lys 
            420                 425                 430         


Asp Phe Tyr Ile Val Glu Pro Leu Ala Phe Glu Gly Thr Pro Glu Gln 
        435                 440                 445             


Lys Ala Leu Val Ile Gly Gly Glu Ala Cys Met Trp Gly Glu Tyr Val 
    450                 455                 460                 


Asp Asn Thr Asn Leu Val Pro Arg Leu Trp Pro Arg Ala Gly Ala Val 
465                 470                 475                 480 


Ala Glu Arg Leu Trp Ser Asn Lys Leu Thr Ser Asp Leu Thr Phe Ala 
                485                 490                 495     


Tyr Glu Arg Leu Ser His Phe Arg Cys Glu Leu Leu Arg Arg Gly Val 
            500                 505                 510         


Gln Ala Gln Pro Leu Asn Val Gly Phe Cys Glu Gln Glu Phe Glu Gln 
        515                 520                 525             


Thr 
    

<210>  29

<211>  2859
<212>  DNA
<213>  homo sapiens

<220>
<223>  GAA polynucleotide sequence

<400>  29
atgggagtga ggcacccgcc ctgctcccac cggctcctgg ccgtctgcgc cctcgtgtcc     60
ttggcaaccg ctgcactcct ggggcacatc ctactccatg atttcctgct ggttccccga    120
gagctgagtg gctcctcccc agtcctggag gagactcacc cagctcacca gcagggagcc    180
agcagaccag ggccccggga tgcccaggca caccccggcc gtcccagagc agtgcccaca    240
cagtgcgacg tcccccccaa cagccgcttc gattgcgccc ctgacaaggc catcacccag    300
gaacagtgcg aggcccgcgg ctgttgctac atccctgcaa agcaggggct gcagggagcc    360
cagatggggc agccctggtg cttcttccca cccagctacc ccagctacaa gctggagaac    420
ctgagctcct ctgaaatggg ctacacggcc accctgaccc gtaccacccc caccttcttc    480
cccaaggaca tcctgaccct gcggctggac gtgatgatgg agactgagaa ccgcctccac    540
ttcacgatca aagatccagc taacaggcgc tacgaggtgc ccttggagac cccgcatgtc    600
cacagccggg caccgtcccc actctacagc gtggagttct ccgaggagcc cttcggggtg    660
atcgtgcgcc ggcagctgga cggccgcgtg ctgctgaaca cgacggtggc gcccctgttc    720
tttgcggacc agttccttca gctgtccacc tcgctgccct cgcagtatat cacaggcctc    780
gccgagcacc tcagtcccct gatgctcagc accagctgga ccaggatcac cctgtggaac    840
cgggaccttg cgcccacgcc cggtgcgaac ctctacgggt ctcacccttt ctacctggcg    900
ctggaggacg gcgggtcggc acacggggtg ttcctgctaa acagcaatgc catggatgtg    960
gtcctgcagc cgagccctgc ccttagctgg aggtcgacag gtgggatcct ggatgtctac   1020
atcttcctgg gcccagagcc caagagcgtg gtgcagcagt acctggacgt tgtgggatac   1080
ccgttcatgc cgccatactg gggcctgggc ttccacctgt gccgctgggg ctactcctcc   1140
accgctatca cccgccaggt ggtggagaac atgaccaggg cccacttccc cctggacgtc   1200
cagtggaacg acctggacta catggactcc cggagggact tcacgttcaa caaggatggc   1260
ttccgggact tcccggccat ggtgcaggag ctgcaccagg gcggccggcg ctacatgatg   1320
atcgtggatc ctgccatcag cagctcgggc cctgccggga gctacaggcc ctacgacgag   1380
ggtctgcgga ggggggtttt catcaccaac gagaccggcc agccgctgat tgggaaggta   1440
tggcccgggt ccactgcctt ccccgacttc accaacccca cagccctggc ctggtgggag   1500
gacatggtgg ctgagttcca tgaccaggtg cccttcgacg gcatgtggat tgacatgaac   1560
gagccttcca acttcatcag gggctctgag gacggctgcc ccaacaatga gctggagaac   1620
ccaccctacg tgcctggggt ggttgggggg accctccagg cggccaccat ctgtgcctcc   1680
agccaccagt ttctctccac acactacaac ctgcacaacc tctacggcct gaccgaagcc   1740
atcgcctccc acagggcgct ggtgaaggct cgggggacac gcccatttgt gatctcccgc   1800
tcgacctttg ctggccacgg ccgatacgcc ggccactgga cgggggacgt gtggagctcc   1860
tgggagcagc tcgcctcctc cgtgccagaa atcctgcagt ttaacctgct gggggtgcct   1920
ctggtcgggg ccgacgtctg cggcttcctg ggcaacacct cagaggagct gtgtgtgcgc   1980
tggacccagc tgggggcctt ctaccccttc atgcggaacc acaacagcct gctcagtctg   2040
ccccaggagc cgtacagctt cagcgagccg gcccagcagg ccatgaggaa ggccctcacc   2100
ctgcgctacg cactcctccc ccacctctac acactgttcc accaggccca cgtcgcgggg   2160
gagaccgtgg cccggcccct cttcctggag ttccccaagg actctagcac ctggactgtg   2220
gaccaccagc tcctgtgggg ggaggccctg ctcatcaccc cagtgctcca ggccgggaag   2280
gccgaagtga ctggctactt ccccttgggc acatggtacg acctgcagac ggtgccagta   2340
gaggcccttg gcagcctccc acccccacct gcagctcccc gtgagccagc catccacagc   2400
gaggggcagt gggtgacgct gccggccccc ctggacacca tcaacgtcca cctccgggct   2460
gggtacatca tccccctgca gggccctggc ctcacaacca cagagtcccg ccagcagccc   2520
atggccctgg ctgtggccct gaccaagggt ggggaggccc gaggggagct gttctgggac   2580
gatggagaga gcctggaagt gctggagcga ggggcctaca cacaggtcat cttcctggcc   2640
aggaataaca cgatcgtgaa tgagctggta cgtgtgacca gtgagggagc tggcctgcag   2700
ctgcagaagg tgactgtcct gggcgtggcc acggcgcccc agcaggtcct ctccaacggt   2760
gtccctgtct ccaacttcac ctacagcccc gacaccaagg tcctggacat ctgtgtctcg   2820
ctgttgatgg gagagcagtt tctcgtcagc tggtgttag                          2859


<210>  30

<211>  952
<212>  PRT
<213>  homo sapiens

<220>
<223>  GAA polypeptide sequence

<400>  30
Met Gly Val Arg His Pro Pro Cys Ser His Arg Leu Leu Ala Val Cys 
1               5                   10                  15      


Ala Leu Val Ser Leu Ala Thr Ala Ala Leu Leu Gly His Ile Leu Leu 
            20                  25                  30          


His Asp Phe Leu Leu Val Pro Arg Glu Leu Ser Gly Ser Ser Pro Val 
        35                  40                  45              


Leu Glu Glu Thr His Pro Ala His Gln Gln Gly Ala Ser Arg Pro Gly 
    50                  55                  60                  


Pro Arg Asp Ala Gln Ala His Pro Gly Arg Pro Arg Ala Val Pro Thr 
65                  70                  75                  80  


Gln Cys Asp Val Pro Pro Asn Ser Arg Phe Asp Cys Ala Pro Asp Lys 
                85                  90                  95      


Ala Ile Thr Gln Glu Gln Cys Glu Ala Arg Gly Cys Cys Tyr Ile Pro 
            100                 105                 110         


Ala Lys Gln Gly Leu Gln Gly Ala Gln Met Gly Gln Pro Trp Cys Phe 
        115                 120                 125             


Phe Pro Pro Ser Tyr Pro Ser Tyr Lys Leu Glu Asn Leu Ser Ser Ser 
    130                 135                 140                 


Glu Met Gly Tyr Thr Ala Thr Leu Thr Arg Thr Thr Pro Thr Phe Phe 
145                 150                 155                 160 


Pro Lys Asp Ile Leu Thr Leu Arg Leu Asp Val Met Met Glu Thr Glu 
                165                 170                 175     


Asn Arg Leu His Phe Thr Ile Lys Asp Pro Ala Asn Arg Arg Tyr Glu 
            180                 185                 190         


Val Pro Leu Glu Thr Pro His Val His Ser Arg Ala Pro Ser Pro Leu 
        195                 200                 205             


Tyr Ser Val Glu Phe Ser Glu Glu Pro Phe Gly Val Ile Val Arg Arg 
    210                 215                 220                 


Gln Leu Asp Gly Arg Val Leu Leu Asn Thr Thr Val Ala Pro Leu Phe 
225                 230                 235                 240 


Phe Ala Asp Gln Phe Leu Gln Leu Ser Thr Ser Leu Pro Ser Gln Tyr 
                245                 250                 255     


Ile Thr Gly Leu Ala Glu His Leu Ser Pro Leu Met Leu Ser Thr Ser 
            260                 265                 270         


Trp Thr Arg Ile Thr Leu Trp Asn Arg Asp Leu Ala Pro Thr Pro Gly 
        275                 280                 285             


Ala Asn Leu Tyr Gly Ser His Pro Phe Tyr Leu Ala Leu Glu Asp Gly 
    290                 295                 300                 


Gly Ser Ala His Gly Val Phe Leu Leu Asn Ser Asn Ala Met Asp Val 
305                 310                 315                 320 


Val Leu Gln Pro Ser Pro Ala Leu Ser Trp Arg Ser Thr Gly Gly Ile 
                325                 330                 335     


Leu Asp Val Tyr Ile Phe Leu Gly Pro Glu Pro Lys Ser Val Val Gln 
            340                 345                 350         


Gln Tyr Leu Asp Val Val Gly Tyr Pro Phe Met Pro Pro Tyr Trp Gly 
        355                 360                 365             


Leu Gly Phe His Leu Cys Arg Trp Gly Tyr Ser Ser Thr Ala Ile Thr 
    370                 375                 380                 


Arg Gln Val Val Glu Asn Met Thr Arg Ala His Phe Pro Leu Asp Val 
385                 390                 395                 400 


Gln Trp Asn Asp Leu Asp Tyr Met Asp Ser Arg Arg Asp Phe Thr Phe 
                405                 410                 415     


Asn Lys Asp Gly Phe Arg Asp Phe Pro Ala Met Val Gln Glu Leu His 
            420                 425                 430         


Gln Gly Gly Arg Arg Tyr Met Met Ile Val Asp Pro Ala Ile Ser Ser 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Tyr Arg Pro Tyr Asp Glu Gly Leu Arg Arg 
    450                 455                 460                 


Gly Val Phe Ile Thr Asn Glu Thr Gly Gln Pro Leu Ile Gly Lys Val 
465                 470                 475                 480 


Trp Pro Gly Ser Thr Ala Phe Pro Asp Phe Thr Asn Pro Thr Ala Leu 
                485                 490                 495     


Ala Trp Trp Glu Asp Met Val Ala Glu Phe His Asp Gln Val Pro Phe 
            500                 505                 510         


Asp Gly Met Trp Ile Asp Met Asn Glu Pro Ser Asn Phe Ile Arg Gly 
        515                 520                 525             


Ser Glu Asp Gly Cys Pro Asn Asn Glu Leu Glu Asn Pro Pro Tyr Val 
    530                 535                 540                 


Pro Gly Val Val Gly Gly Thr Leu Gln Ala Ala Thr Ile Cys Ala Ser 
545                 550                 555                 560 


Ser His Gln Phe Leu Ser Thr His Tyr Asn Leu His Asn Leu Tyr Gly 
                565                 570                 575     


Leu Thr Glu Ala Ile Ala Ser His Arg Ala Leu Val Lys Ala Arg Gly 
            580                 585                 590         


Thr Arg Pro Phe Val Ile Ser Arg Ser Thr Phe Ala Gly His Gly Arg 
        595                 600                 605             


Tyr Ala Gly His Trp Thr Gly Asp Val Trp Ser Ser Trp Glu Gln Leu 
    610                 615                 620                 


Ala Ser Ser Val Pro Glu Ile Leu Gln Phe Asn Leu Leu Gly Val Pro 
625                 630                 635                 640 


Leu Val Gly Ala Asp Val Cys Gly Phe Leu Gly Asn Thr Ser Glu Glu 
                645                 650                 655     


Leu Cys Val Arg Trp Thr Gln Leu Gly Ala Phe Tyr Pro Phe Met Arg 
            660                 665                 670         


Asn His Asn Ser Leu Leu Ser Leu Pro Gln Glu Pro Tyr Ser Phe Ser 
        675                 680                 685             


Glu Pro Ala Gln Gln Ala Met Arg Lys Ala Leu Thr Leu Arg Tyr Ala 
    690                 695                 700                 


Leu Leu Pro His Leu Tyr Thr Leu Phe His Gln Ala His Val Ala Gly 
705                 710                 715                 720 


Glu Thr Val Ala Arg Pro Leu Phe Leu Glu Phe Pro Lys Asp Ser Ser 
                725                 730                 735     


Thr Trp Thr Val Asp His Gln Leu Leu Trp Gly Glu Ala Leu Leu Ile 
            740                 745                 750         


Thr Pro Val Leu Gln Ala Gly Lys Ala Glu Val Thr Gly Tyr Phe Pro 
        755                 760                 765             


Leu Gly Thr Trp Tyr Asp Leu Gln Thr Val Pro Val Glu Ala Leu Gly 
    770                 775                 780                 


Ser Leu Pro Pro Pro Pro Ala Ala Pro Arg Glu Pro Ala Ile His Ser 
785                 790                 795                 800 


Glu Gly Gln Trp Val Thr Leu Pro Ala Pro Leu Asp Thr Ile Asn Val 
                805                 810                 815     


His Leu Arg Ala Gly Tyr Ile Ile Pro Leu Gln Gly Pro Gly Leu Thr 
            820                 825                 830         


Thr Thr Glu Ser Arg Gln Gln Pro Met Ala Leu Ala Val Ala Leu Thr 
        835                 840                 845             


Lys Gly Gly Glu Ala Arg Gly Glu Leu Phe Trp Asp Asp Gly Glu Ser 
    850                 855                 860                 


Leu Glu Val Leu Glu Arg Gly Ala Tyr Thr Gln Val Ile Phe Leu Ala 
865                 870                 875                 880 


Arg Asn Asn Thr Ile Val Asn Glu Leu Val Arg Val Thr Ser Glu Gly 
                885                 890                 895     


Ala Gly Leu Gln Leu Gln Lys Val Thr Val Leu Gly Val Ala Thr Ala 
            900                 905                 910         


Pro Gln Gln Val Leu Ser Asn Gly Val Pro Val Ser Asn Phe Thr Tyr 
        915                 920                 925             


Ser Pro Asp Thr Lys Val Leu Asp Ile Cys Val Ser Leu Leu Met Gly 
    930                 935                 940                 


Glu Gln Phe Leu Val Ser Trp Cys 
945                 950         


<210>  31

<211>  1896
<212>  DNA
<213>  homo sapiens

<220>
<223>  SMPD1 polynucleotide sequence

<400>  31
atgccccgct acggagcgtc actccgccag agctgcccca ggtccggccg ggagcaggga     60
caagacggga ccgccggagc ccccggactc ctttggatgg gcctggtgct ggcgctggcg    120
ctggcgctgg cgctggcgct ggctctgtct gactctcggg ttctctgggc tccggcagag    180
gctcaccctc tttctcccca aggccatcct gccaggttac atcgcatagt gccccggctc    240
cgagatgtct ttgggtgggg gaacctcacc tgcccaatct gcaaaggtct attcaccgcc    300
atcaacctcg ggctgaagaa ggaacccaat gtggctcgcg tgggctccgt ggccatcaag    360
ctgtgcaatc tgctgaagat agcaccacct gccgtgtgcc aatccattgt ccacctcttt    420
gaggatgaca tggtggaggt gtggagacgc tcagtgctga gcccatctga ggcctgtggc    480
ctgctcctgg gctccacctg tgggcactgg gacattttct catcttggaa catctctttg    540
cctactgtgc cgaagccgcc ccccaaaccc cctagccccc cagccccagg tgcccctgtc    600
agccgcatcc tcttcctcac tgacctgcac tgggatcatg actacctgga gggcacggac    660
cctgactgtg cagacccact gtgctgccgc cggggttctg gcctgccgcc cgcatcccgg    720
ccaggtgccg gatactgggg cgaatacagc aagtgtgacc tgcccctgag gaccctggag    780
agcctgttga gtgggctggg cccagccggc ccttttgata tggtgtactg gacaggagac    840
atccccgcac atgatgtctg gcaccagact cgtcaggacc aactgcgggc cctgaccacc    900
gtcacagcac ttgtgaggaa gttcctgggg ccagtgccag tgtaccctgc tgtgggtaac    960
catgaaagca cacctgtcaa tagcttccct ccccccttca ttgagggcaa ccactcctcc   1020
cgctggctct atgaagcgat ggccaaggct tgggagccct ggctgcctgc cgaagccctg   1080
cgcaccctca gaattggggg gttctatgct ctttccccat accccggtct ccgcctcatc   1140
tctctcaata tgaatttttg ttcccgtgag aacttctggc tcttgatcaa ctccacggat   1200
cccgcaggac agctccagtg gctggtgggg gagcttcagg ctgctgagga tcgaggagac   1260
aaagtgcata taattggcca cattccccca gggcactgtc tgaagagctg gagctggaat   1320
tattaccgaa ttgtagccag gtatgagaac accctggctg ctcagttctt tggccacact   1380
catgtggatg aatttgaggt cttctatgat gaagagactc tgagccggcc gctggctgta   1440
gccttcctgg cacccagtgc aactacctac atcggcctta atcctggtta ccgtgtgtac   1500
caaatagatg gaaactactc cgggagctct cacgtggtcc tggaccatga gacctacatc   1560
ctgaatctga cccaggcaaa cataccggga gccataccgc actggcagct tctctacagg   1620
gctcgagaaa cctatgggct gcccaacaca ctgcctaccg cctggcacaa cctggtatat   1680
cgcatgcggg gcgacatgca acttttccag accttctggt ttctctacca taagggccac   1740
ccaccctcgg agccctgtgg cacgccctgc cgtctggcta ctctttgtgc ccagctctct   1800
gcccgtgctg acagccctgc tctgtgccgc cacctgatgc cagatgggag cctcccagag   1860
gcccagagcc tgtggccaag gccactgttt tgctag                             1896

<210>  32

<211>  631
<212>  PRT
<213>  homo sapiens

<220>
<223>  SMPD1 polypeptide sequence

<400>  32
Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  33

<211>  1200
<212>  DNA
<213>  homo sapiens

<220>
<223>  LIPA polynucleotide sequence

<400>  33
atgaaaatgc ggttcttggg gttggtggtc tgtttggttc tctggaccct gcattctgag     60
gggtctggag ggaaactgac agctgtggat cctgaaacaa acatgaatgt gagtgaaatt    120
atctcttact ggggattccc tagtgaggaa tacctagttg agacagaaga tggatatatt    180
ctgtgcctta accgaattcc tcatgggagg aagaaccatt ctgacaaagg tcccaaacca    240
gttgtcttcc tgcaacatgg cttgctggca gattctagta actgggtcac aaaccttgcc    300
aacagcagcc tgggcttcat tcttgctgat gctggttttg acgtgtggat gggcaacagc    360
agaggaaata cctggtctcg gaaacataag acactctcag tttctcagga tgaattctgg    420
gctttcagtt atgatgagat ggcaaaatat gacctaccag cttccattaa cttcattctg    480
aataaaactg gccaagaaca agtgtattat gtgggtcatt ctcaaggcac cactataggt    540
tttatagcat tttcacagat ccctgagctg gctaaaagga ttaaaatgtt ttttgccctg    600
ggtcctgtgg cttccgtcgc cttctgtact agccctatgg ccaaattagg acgattacca    660
gatcatctca ttaaggactt atttggagac aaagaatttc ttccccagag tgcgtttttg    720
aagtggctgg gtacccacgt ttgcactcat gtcatactga aggagctctg tggaaatctc    780
tgttttcttc tgtgtggatt taatgagaga aatttaaata tgtctagagt ggatgtatat    840
acaacacatt ctcctgctgg aacttctgtg caaaacatgt tacactggag ccaggctgtt    900
aaattccaaa agtttcaagc ctttgactgg ggaagcagtg ccaagaatta ttttcattac    960
aaccagagtt atcctcccac atacaatgtg aaggacatgc ttgtgccgac tgcagtctgg   1020
agcgggggtc acgactggct tgcagatgtc tacgacgtca atatcttact gactcagatc   1080
accaacttgg tgttccatga gagcattccg gaatgggagc atcttgactt catttggggc   1140
ctggatgccc cttggaggct ttataataaa attattaatc taatgaggaa atatcagtga   1200

<210>  34

<211>  399
<212>  PRT
<213>  homo sapiens

<220>
<223>  LIPA polypeptide sequence

<400>  34
Met Lys Met Arg Phe Leu Gly Leu Val Val Cys Leu Val Leu Trp Thr 
1               5                   10                  15      


Leu His Ser Glu Gly Ser Gly Gly Lys Leu Thr Ala Val Asp Pro Glu 
            20                  25                  30          


Thr Asn Met Asn Val Ser Glu Ile Ile Ser Tyr Trp Gly Phe Pro Ser 
        35                  40                  45              


Glu Glu Tyr Leu Val Glu Thr Glu Asp Gly Tyr Ile Leu Cys Leu Asn 
    50                  55                  60                  


Arg Ile Pro His Gly Arg Lys Asn His Ser Asp Lys Gly Pro Lys Pro 
65                  70                  75                  80  


Val Val Phe Leu Gln His Gly Leu Leu Ala Asp Ser Ser Asn Trp Val 
                85                  90                  95      


Thr Asn Leu Ala Asn Ser Ser Leu Gly Phe Ile Leu Ala Asp Ala Gly 
            100                 105                 110         


Phe Asp Val Trp Met Gly Asn Ser Arg Gly Asn Thr Trp Ser Arg Lys 
        115                 120                 125             


His Lys Thr Leu Ser Val Ser Gln Asp Glu Phe Trp Ala Phe Ser Tyr 
    130                 135                 140                 


Asp Glu Met Ala Lys Tyr Asp Leu Pro Ala Ser Ile Asn Phe Ile Leu 
145                 150                 155                 160 


Asn Lys Thr Gly Gln Glu Gln Val Tyr Tyr Val Gly His Ser Gln Gly 
                165                 170                 175     


Thr Thr Ile Gly Phe Ile Ala Phe Ser Gln Ile Pro Glu Leu Ala Lys 
            180                 185                 190         


Arg Ile Lys Met Phe Phe Ala Leu Gly Pro Val Ala Ser Val Ala Phe 
        195                 200                 205             


Cys Thr Ser Pro Met Ala Lys Leu Gly Arg Leu Pro Asp His Leu Ile 
    210                 215                 220                 


Lys Asp Leu Phe Gly Asp Lys Glu Phe Leu Pro Gln Ser Ala Phe Leu 
225                 230                 235                 240 


Lys Trp Leu Gly Thr His Val Cys Thr His Val Ile Leu Lys Glu Leu 
                245                 250                 255     


Cys Gly Asn Leu Cys Phe Leu Leu Cys Gly Phe Asn Glu Arg Asn Leu 
            260                 265                 270         


Asn Met Ser Arg Val Asp Val Tyr Thr Thr His Ser Pro Ala Gly Thr 
        275                 280                 285             


Ser Val Gln Asn Met Leu His Trp Ser Gln Ala Val Lys Phe Gln Lys 
    290                 295                 300                 


Phe Gln Ala Phe Asp Trp Gly Ser Ser Ala Lys Asn Tyr Phe His Tyr 
305                 310                 315                 320 


Asn Gln Ser Tyr Pro Pro Thr Tyr Asn Val Lys Asp Met Leu Val Pro 
                325                 330                 335     


Thr Ala Val Trp Ser Gly Gly His Asp Trp Leu Ala Asp Val Tyr Asp 
            340                 345                 350         


Val Asn Ile Leu Leu Thr Gln Ile Thr Asn Leu Val Phe His Glu Ser 
        355                 360                 365             


Ile Pro Glu Trp Glu His Leu Asp Phe Ile Trp Gly Leu Asp Ala Pro 
    370                 375                 380                 


Trp Arg Leu Tyr Asn Lys Ile Ile Asn Leu Met Arg Lys Tyr Gln 
385                 390                 395                 


<210>  35

<211>  3093
<212>  DNA
<213>  homo sapiens

<220>
<223>  CDKL5 polynucleotide sequence

<400>  35
atgaagattc ctaacattgg taatgtgatg aataaatttg agatccttgg ggttgtaggt     60
gaaggagcct atggagttgt acttaaatgc agacacaagg aaacacatga aattgtggcg    120
atcaagaaat tcaaggacag tgaagaaaat gaagaagtca aagaaacgac tttacgagag    180
cttaaaatgc ttcggactct caagcaggaa aacattgtgg agttgaagga agcatttcgt    240
cggaggggaa agttgtactt ggtgtttgag tatgttgaaa aaaatatgct cgaattgctg    300
gaagaaatgc caaatggagt tccacctgag aaagtaaaaa gctacatcta tcagctaatc    360
aaggctattc actggtgcca taagaatgat attgtccatc gagatataaa accagaaaat    420
ctcttaatca gccacaatga tgtcctaaaa ctgtgtgact ttggttttgc tcgtaatctg    480
tcagaaggca ataatgctaa ttacacagag tacgttgcca ccagatggta tcggtcccca    540
gaactcttac ttggcgctcc ctatggaaag tccgtggaca tgtggtcggt gggctgtatt    600
cttggggagc ttagcgatgg acagccttta tttcctggag aaagtgaaat tgaccaactt    660
tttactattc agaaggtgct aggaccactt ccatctgagc agatgaagct tttctacagt    720
aatcctcgct tccatgggct ccggtttcca gctgttaacc atcctcagtc cttggaaaga    780
agataccttg gaattttgaa tagtgttcta cttgacctaa tgaagaattt actgaagttg    840
gacccagctg acagatactt gacagaacag tgtttgaatc accctacatt tcaaacccag    900
agacttctgg atcgttctcc ttcaaggtca gcaaaaagaa aaccttacca tgtggaaagc    960
agcacattgt ctaatagaaa ccaagccggc aaaagtactg ctttgcagtc tcaccacaga   1020
tctaacagca aggacatcca gaacctgagt gtaggcctgc cccgggctga cgaaggtctc   1080
cctgccaatg aaagcttcct aaatggaaac cttgctggag ctagtcttag tccactgcac   1140
accaaaacct accaagcaag cagccagcct gggtctacca gcaaagatct caccaacaac   1200
aacataccac accttcttag cccaaaagaa gccaagtcaa aaacagagtt tgattttaat   1260
attgacccaa agccttcaga aggcccaggg acaaagtacc tcaagtcaaa cagcagatct   1320
cagcagaacc gccactcatt catggaaagc tctcaaagca aagctgggac actgcagccc   1380
aatgaaaagc agagtcggca tagctatatt gacacaattc cccagtcctc taggagtccc   1440
tcctacagga ccaaggccaa aagccatggg gcactgagtg actccaagtc tgtgagcaac   1500
ctttctgaag ccagggccca aattgcggag cccagtacca gtaggtactt cccatctagc   1560
tgcttagact tgaattctcc caccagccca acccccacca gacacagtga cacgagaact   1620
ttgctcagcc cttctggaag aaataaccga aatgagggaa cgctggactc acgtcgaacc   1680
acaaccagac attctaagac gatggaggaa ttgaagctgc cggagcacat ggacagtagc   1740
cattcccatt cactgtctgc acctcacgaa tctttttctt atggactggg ctacaccagc   1800
cccttttctt cccagcaacg tcctcatagg cattctatgt atgtgacccg tgacaaagtg   1860
agagccaagg gcttggatgg aagcttgagc atagggcaag ggatggcagc tagagccaac   1920
agcctgcaac tcttgtcacc ccagcctgga gaacagctcc ctccagagat gactgtggca   1980
agatcttcgg tcaaagagac ctccagagaa ggcacctctt ccttccatac acgccagaag   2040
tctgagggtg gagtgtatca tgacccacac tctgatgatg gcacagcccc caaagaaaat   2100
agacacctat acaatgatcc tgtgccaagg agagttggta gcttttacag agtgccatct   2160
ccacgtccag acaattcttt ccatgaaaat aatgtgtcaa ctagagtttc ttctctacca   2220
tcagagagca gttctggaac caaccactca aaaagacaac cagcattcga tccatggaaa   2280
agtcctgaaa atattagtca ttcagagcaa ctcaaggaaa aagagaagca aggatttttc   2340
aggtcaatga aaaagaaaaa gaagaaatct caaacagtac ccaattccga cagccctgat   2400
cttctgacgt tgcagaaatc cattcattct gctagcactc caagcagcag accaaaggag   2460
tggcgccccg agaagatctc agatctgcag acccaaagcc agccattaaa atcactgcgc   2520
aagttgttac atctctcttc ggcctcaaat cacccggctt cctcagatcc ccgcttccag   2580
cccttaacag ctcaacaaac caaaaattcc ttctcagaaa ttcggattca ccccctgagc   2640
caggcctctg gcgggagcag caacatccgg caggaacccg caccgaaggg caggccagcc   2700
ctccagctgc cagacggtgg atgtgatggc agaagacaga gacaccattc tggaccccaa   2760
gatagacgct tcatgttaag gacgacagaa caacaaggag aatacttctg ctgtggtgac   2820
ccaaagaagc ctcacactcc gtgcgtccca aaccgagccc ttcatcgtcc aatctccagt   2880
cctgctccct atccagtact ccaggtccga ggcacttcca tgtgcccgac actccaggtc   2940
cgaggcactg atgctttcag ctgcccaacc cagcaatccg ggttctcttt cttcgtgaga   3000
cacgttatga gggaagccct gattcacagg gcccaggtaa accaagctgc gctcctgaca   3060
taccatgaga atgcggcact gacgggcaag tga                                3093

<210>  36

<211>  1030
<212>  PRT
<213>  homo sapiens

<220>
<223>  CDKL5 polypeptide sequence

<400>  36
Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
            900                 905                 910         


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
        915                 920                 925             


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
    930                 935                 940                 


His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser 
945                 950                 955                 960 


Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro 
                965                 970                 975     


Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln 
            980                 985                 990         


Ser Gly Phe Ser Phe Phe Val Arg His Val Met Arg Glu Ala Leu Ile 
        995                 1000                1005            


His Arg Ala Gln Val Asn Gln Ala Ala Leu Leu Thr Tyr His Glu Asn 
    1010                1015                1020                


Ala Ala Leu Thr Gly Lys 
1025                1030


<210>  37

<211>  18
<212>  PRT
<213>  homo sapiens

<220>
<223>  Albumin peptide

<400>  37
Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser 
        


<210>  38

<211>  18
<212>  PRT
<213>  homo sapiens

<220>
<223>  chymotrypsinogen peptide

<400>  38
Met Ala Phe Leu Trp Leu Leu Ser Cys Trp Ala Leu Leu Gly Thr Thr 
1               5                   10                  15      


Phe Gly 
        


<210>  39

<211>  14
<212>  PRT
<213>  homo sapiens

<220>
<223>  interleukin-2 peptide

<400>  39
Met Gln Leu Leu Ser Cys Ile Ala Leu Ile Leu Ala Leu Val 
1               5                   10                  


<210>  40

<211>  15
<212>  PRT
<213>  homo sapiens

<220>
<223>  trypsinogen-2 peptide

<400>  40
Met Asn Leu Leu Leu Ile Leu Thr Phe Val Ala Ala Ala Val Ala 
1               5                   10                  15  


<210>  41

<211>  17
<212>  PRT
<213>  homo sapiens

<220>
<223>  BM40 peptide

<400>  41
Met Arg Ala Trp Ile Phe Phe Leu Leu Cys Leu Ala Gly Arg Ala Leu 
1               5                   10                  15      


Ala 
    


<210>  42

<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Secrecon

<400>  42
Met Trp Trp Arg Leu Trp Trp Leu Leu Leu Leu Leu Leu Leu Leu Trp 
1               5                   10                  15      


Pro Met Val Trp Ala 
            20      


<210>  43

<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  Mouse IgKVIII

<400>  43
Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  44

<211>  22
<212>  PRT
<213>  artificial

<220>
<223>  Human IgKVIII

<400>  44
Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  45

<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  CD33

<400>  45
Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 
1               5                   10                  15      






<210>  46

<211>  23
<212>  PRT
<213>  artificial

<220>
<223>  tPA

<400>  46
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Ser 
            20              


<210>  47

<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Consensus

<400>  47
Met Leu Leu Leu Leu Leu Leu Leu Leu Leu Leu Ala Leu Ala Leu Ala 
1               5                   10                  15      






<210>  48

<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Native

<400>  48
Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu Ser Leu 
1               5                   10                  15      


Gly 
    


<210>  49

<211>  16
<212>  PRT
<213>  artificial

<220>
<223>  Penetratin

<400>  49
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      






<210>  50

<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  TAT

<400>  50
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210>  51

<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  SynB1

<400>  51
Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr 
1               5                   10                  15      


Gly Arg 
        


<210>  52

<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  SynB3

<400>  52
Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe 
1               5                   10  


<210>  53

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PTD-4

<400>  53
Pro Ile Arg Arg Arg Lys Lys Leu Arg Arg Leu Lys 
1               5                   10          


<210>  54

<211>  12
<212>  PRT
<213>  artificial

<220>
<223>  PTD-5

<400>  54
Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 
1               5                   10          


<210>  55

<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  FHV Coat

<400>  55
Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  


<210>  56

<211>  19
<212>  PRT
<213>  artificial

<220>
<223>  BMV Gag

<400>  56
Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      


Thr Ala Arg 
            


<210>  57

<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  HTLV-II Rex

<400>  57
Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              


<210>  58

<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  D-Tat

<400>  58
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  59

<211>  13
<212>  PRT
<213>  artificial

<220>
<223>  R9-Tat

<400>  59
Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  60

<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  Transportan

<400>  60
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  61

<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  MAP

<400>  61
Lys Leu Ala Leu Lys Leu Ala Leu Lys Leu Ala Leu Ala Leu Lys Leu 
1               5                   10                  15      


Ala 
    


<210>  62

<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  SBP

<400>  62
Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  63

<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  FBP

<400>  63
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  64

<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  MPG ac

<400>  64
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val 
            20                  25          


<210>  65

<211>  27
<212>  PRT
<213>  artificial

<220>
<223>  MPG(&#916;NLS)

<400>  65
Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val 
            20                  25          


<210>  66

<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-1

<400>  66
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  67

<211>  21
<212>  PRT
<213>  artificial

<220>
<223>  Pep-2

<400>  67
Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  68

<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p1

<400>  68
Leu Arg Lys Leu Arg Lys Arg Leu Leu Leu Arg Lys Leu Arg Lys Arg 
1               5                   10                  15      


Leu Leu 
        


<210>  69

<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p2

<400>  69
Leu Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu Leu 
1               5                   10                  15      


Arg Lys Leu Arg Lys Arg Leu Leu Arg Asp Ala Asp Asp Leu 
            20                  25                  30  


<210>  70

<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p3

<400>  70
Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu 
    


<210>  71

<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p4

<400>  71
Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg 
1               5                   10                  15      


Lys Arg Leu Leu 
            20  


<210>  72

<211>  34
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p5

<400>  72
Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg Leu 
1               5                   10                  15      


Leu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg Lys Arg 
            20                  25                  30          


Leu Leu 
        


<210>  73

<211>  40
<212>  PRT
<213>  artificial

<220>
<223>  ApoE p6

<400>  73
Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu Arg Lys Leu Arg 
1               5                   10                  15      


Lys Arg Leu Leu Thr Glu Glu Leu Arg Val Arg Leu Ala Ser His Leu 
            20                  25                  30          


Arg Lys Leu Arg Lys Arg Leu Leu 
        35                  40  


<210>  74

<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Myc Peptide

<400>  74
Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  75

<211>  39
<212>  PRT
<213>  artificial

<220>
<223>  ApoB Peptide

<400>  75
Ser Ser Val Ile Asp Ala Leu Gln Tyr Lys Leu Glu Gly Thr Thr Arg 
1               5                   10                  15      


Leu Thr Arg Lys Arg Gly Leu Lys Leu Ala Thr Ala Leu Ser Leu Ser 
            20                  25                  30          


Asn Lys Phe Val Glu Gly Ser 
        35                  

<210>  76

<211>  18242
<212>  DNA
<213>  homo sapiens

<220>
<223>  CX3CR1_loci

<400>  76
ggggcgggcc gtgcttacca ggccgtggac ttaaaccagg atgagagaac ccctggaggc     60
gtttaagttg gcagacttgg atttcaggaa gagctctctg gcttctgggt ggagaatggc    120
cagtggggta agtggtgaga ggaaagacag agaacggaga aggttagatg ggcttgggaa    180
attatccagg ccctggatgg aggtagagat gtgtgctcat gaacacggag gggattactg    240
atgtggggtg gatgagactg tcgtcaagag tgtgggacag gaagagaggg agagtcttgg    300
ccagatccaa gaaaggagcc ctcagaagag gaggggagtc agaggcaagg aaggggctga    360
ggcagccagc ccagctgagt ggaccccagg agaggtatca aggggtggtg tggggtgggg    420
aggggccagt gtcagaaagt ggatggggag cggcctgact ctgcttttgt cctgtggcct    480
tctggccaaa ggcagggaaa ggtggccaaa cactgagacc aagaacaaag aaagaaaact    540
gctggtggac ttcttccacc atgagcaggc caccaagccc gcagcactgc actgcagccc    600
ccagctctgt cctggggttg ggggaggtga ggaggggcaa ggtggggagc acacagagca    660
cccgctgtcc tcggaacacc acagcgacta gaggtaaggg agcaccggat gtggctggga    720
tgtgggcagc aaggggccag aggggccttg aaggggtcac agaccattta atgaaggtgt    780
attgaaggcc accatgggcc aggccctagt tagggatgga tcagaattat atagcatatg    840
ccaggggtca ggcaggtaat gaagtgatcg gaaggtgatg aggcagtggc agttgagatt    900
cacgttgcag tcgccccaag ctggccaggc cagggagcag aagcatggct ggatgccgga    960
gcccaccagg ctccccactg cagggcaaga gtggcagggg gagagactgt gaaaggagca   1020
taggccaggt cctgggtgaa agctgtgtcc tcagccttga ctgatgggta tagggagcca   1080
ctaaatgcct tggggcagag aggtgaggaa aaaaatattt accgagcatc tacaaggtgc   1140
aaggtactca ctagatgcct tcagtaccaa agcttctcaa acttagtatg catatcactc   1200
ttctaagaat ttcattaaaa tgcagattct aattcagcag atatagggca gggcttgagg   1260
tgctgtcttt aataagctcc cagtgcctgg gactgcactt tgaggagaag agctgtgtgt   1320
gccccagtgt ggtccagtga gtactctggg ctccctctcg tgggcaggga agctgagggc   1380
cccatgagct ctcccagctt cctgaaggct ccccattaat gagagctgac tgtgctgtgc   1440
tttgctgact gcagggcctg ctccctgccc cccacctcca ggttggggta agtggcacct   1500
ctctccctcc agctccgcag tcttccctga ggtttagatc ttccaggttt ataaagtcag   1560
gccctcctgt tggcagctgg cctccaccct ggagtatctg agcttgcctg tggcagcatc   1620
taaagatagt ctcccttaca ggaaacaaga tactattggc taactctgca aataaaatgc   1680
tcttagaggg aaggaaaggg aaatactcgt ctctggtaaa gtctgagcag gacagggtgg   1740
ctgactggca gatccagagg ttcccttggc agtccacgcc aggtaggtgc acaggactag   1800
ttgggtacct gtgggtgggg tggagcagtg gacagctaat aggttaataa tgcctgtttg   1860
cttacgtgca gacaatggaa accattttcc tggggatgtt gtagcctaaa tatgtccaag   1920
gggatggaag agtgggaggc aaggggtgat cagatcattt ataatacact caacctggtg   1980
gaatagtatt agaagcatta gtaattacat tttagagaca tggagaaaag ctcatgattt   2040
taaactaact gaaaaaagca tgaaaaattg catctggatg ctgttgagga attattgcta   2100
attttttgag atgagaaatt gtattaaagt ctttttcaaa aaagagtcct taacttttag   2160
agatgcacac aagtgtttat gggtgaaatt aaataattca gtagagacat taagtgggaa   2220
atagaggaaa tattgaccat gggttgctaa tagttgaagc caggtgttgg gtataaggag   2280
gttctcgctg cttttatttg aaaagttgct ttttatttga aaatttaata ataaagagtt   2340
tttaaatttg tatctgtatt ttaatataaa tataaatgca cttaatataa atataaaata   2400
tgtataacat ttagatagag aaaagctaaa agattactgt ggttgattct aggaaactgc   2460
attgcagata gtttcatggg tttttttttc ctttttcttc cactttttgt accatctatg   2520
ggtttttgtt tgttttttgt tttttgggtt ttctttcttg tttgtgtttt gttttttgag   2580
acggagtttt gctcttgttg cctaagctgg agtgcaatgg cacagtctcg gctcactgca   2640
acctctgcct cctgggttca agtgattctc ctgcctcagc ctcccaagta gctgggatta   2700
taggcatgta ccaccgcccg gctaattttg tatttttagt agaggcgggg tttctccatt   2760
aataaattcc tggcacaaat ttagtgttca attttgatat atgttgttat aaccattgtg   2820
aggatactca ggctcaggtt tgtgtgggtg gaaaacatgg tcttcagaaa gaaattatga   2880
gtgcaagaca ggaggaaatc catcagaggc cccagctgag gactgaccac ggcttgttat   2940
ttctcttgcc ttgcctctgg caatcacagc ctcacagagc ctgcaatcct tgctttgtga   3000
gtttatagct cagtccagag aatggctaag aaagtttagg attctttcaa cacccactcc   3060
acaaaaaaaa aaaaaaaaaa gaaaagaaaa aaaaattaat ttttgaaata cttgaggtag   3120
aaaacttgag gcagaaaaaa attgagccaa aaaaaaagga aaattgaacc acgtgaaagc   3180
aggcaagaaa gcttgcattg ctcagggcat cccaggccca gagggcgctt tggagggagc   3240
tgggtttcct gagaggaggc agggtgggtg acggacctgt gctggagagc cttgaggacc   3300
actgtgggtt gggaatgggg gcagtggatt ggggttcaaa acccctggga atgagaaatg   3360
ggctcaggaa ggctagggtg gattctttca tcttcctctt tgcttggctt tattttcaca   3420
aaggaaggca gggcaggaaa tagtctcagc ccaacttcag tgtggttctt cttagtgctc   3480
aggcttacct ggcacttgcc acacctctgg gatgggagca cctactatcc atcagccacg   3540
tgccagtctc cacaaagtct gctcctgaac cctgctcctc agctggcccc acttcacaga   3600
tggggacata ggcagcttgg ctttggaatg aaggaatgaa gtcaggaatg aagtcctggc   3660
tctgcacttg gtgactgtgc actgggcttg ctaagtctgt ttcctgcttt taaaatggag   3720
attgtccatc agcctttgaa gccatgtaat gggtatgtgt caactttctg caaggattaa   3780
aggcatggta taggaagtcc caaacacact gcctgaccca tctttgatgc tcaagaaacg   3840
atatatgttg ttgtcatgag gaaactgagc ctcagaaagt ttggatacct gaaaaacact   3900
gactactatt gaatgaggtt gtgaagaatc cagagctgta ggggcaggaa agcaaagaac   3960
gtattagagc tgacccagtc aggacgatcg tctatcccct tcctcacccc accccatccc   4020
aggaggaagc ctgcccggcc ctaggcagct atggcacagt ggcaatgtca ggtatggttc   4080
tccctagcca gagaccctag cctcaaaaaa cctccttctt gggatccagg catccaactg   4140
ctcctcccca gccccagcct ctgacccagt atcctgagtc cagagacgtt tggaaccagc   4200
acctgtaatg gaggagctga acaaggaggg gaacttctgc tgctccacag caggtcacgg   4260
tcataggagg gagtggaacc agaatggcag aatccagatc ttggctgcct ttcccaagga   4320
cttgttctga ttcctagcag cacagcccag gcattccgag aagttgggct ctctggcatc   4380
actcactctg cccagaagag ccaggggaaa gttggggctt ctagctgaac cttgatccca   4440
cctgccctct tgaggggctc agaatctgct ggctgcttca caggtgggat tctcacggca   4500
cgctggccac agctgatgct tcgaccccct catcttgttt ggccaaagtg cagcttttta   4560
gcttgtgagt aaggaagaaa agctgtatca tatgtcttta aacatcttcc tagaccacct   4620
ttgttttccc cttaaagtgt gcttaaggag aaaatggaaa gtctcttttc agtgtgttgt   4680
attttgttta ttgcaaaata caacacactg aaagaacaat gtctgggtta gcaaagtatt   4740
agatttaatt tcccacatta ctaccatcca ggctgagaaa gagaacccca gaagcctctc   4800
tcatgtccct tcctgaccac agcctcttcc tctcccacaa agaaccacaa gtctgacttc   4860
tatggtgatc acttccttgc ttttccctat agtttgactg aatctaaata tcatccctaa   4920
acaatatagc ttagctttgc ctatttttga tcttcatatt tggattcata ctttttggtt   4980
tggctcaaga ctaaactttt aaaatgcatc cacgttgtag gagatgtaca tgcacaaaaa   5040
ttttcacggc aacattgtcc aaactagcaa caaactgaaa gccacctatg tgtgcattag   5100
cagtagaaat ggcaataaat catggactag tcacacagtg gaatcctacg cagcaaggag   5160
aattagcagt ctacagccaa accaacagca tgggtgagat gcttccagaa atactgagat   5220
gaatttagag ataaaggcac aattggtcca tatctacagg gcacttaatc cagtgcatct   5280
ccactagaca aaatttgtat ttccatgagc aagagtcatt tgcactgcta tctgctataa   5340
cctacggtgc tgtaaaatta gctcaggcaa taaaaggggg aggtagcccc aaagagtatg   5400
ccagaaagga ctcccagtaa tcttcagtgt gtgtctattt caaagtcttt catcattttt   5460
ccttgtagtt acttagtgtg gaatttcaga cccctctcta tgtccctctt ctcccttttc   5520
agccttggct ttctctgcat ccttccccga agccctgcac tcagcctaaa ctgactttcc   5580
tgaacactct gggagcatgt gggctcctcc caactccacc atcttcactg ccttctgttc   5640
ctatttccct ctgcctggcc ttggccccag gaaaccttcc tatgctcaga ccctctgtgc   5700
ctttgtcttc aaagcccacc cactattcac tgccacctcc atcttggtca acctggaaga   5760
ctttccccat ccttaaaaca tcagctcaaa cggcagattt tttttttttt ttttgtgata   5820
tcctcttgat caccctcccc cagtttttaa ggagacagat atagaggttc aatccttggg   5880
cttcccatga cttttcttat attctgttac tgagcaataa taaacacttc taggaactgt   5940
atcttaaaca cttttgcctc tacagaatct agcacagtgc ctagtattgg tgaaatataa   6000
ttaacaaagt cttctttcaa cacagagatt ctctccacaa aaggagtaga gaaagaacag   6060
ttttattatg gaataagcag taaaccaaaa tatgcagagc attataggcc atctactaag   6120
aggttgcaag aacagaaaga aatctccccc ttttgtatag ccaagtagat acaacctgtt   6180
acatacatgt tatcaaggca aacaataact gttcctcaag taagaggtct tgccagcacc   6240
gtttgccgta catggttcac tctaaattta cctggtaatt agggtaacca cttgtgttag   6300
ctaactggct ctacccagag gaaaatcaaa tttatcttta agacaagggg taattttgca   6360
gcactgagca aggctcttca gttaggctca taccttccca cagaaactaa gagatagaag   6420
cactatctcc cttaggtttg tttacatttc aaagagatga cgcccaggtc cttgggaaag   6480
actagcttag ctcataaagc tgacaaaaag cctatctagt ttcaaaagga tttacacatg   6540
ttcaaagaga ggagaaagta tgtaaaagtt ttctaggtgg gcacggtggc tcacacctgt   6600
attcccagca ctttgagagg ctgaggcggg tggatcacct gaagtcagga atttgagatc   6660
agcctggcca acatggtgaa accttgtctc tactaaaaat acaaaaatta gctgggcatg   6720
gtggtgggcg cctgtaatcc cagctacttg ggaggctgag gcaggagaat cacttgaacc   6780
caggaggtgg aggtggcagt gagccaagat ggcaccattg cactccagcc tgggcgatga   6840
gagtgaaact ccatgtcaaa aaaaaaaaaa gttttctaaa gtaaatgctc tgagaaaaaa   6900
acagaaggtg aggagatctc tgtccttatt tttaacaaga ataattaaat gtttttattt   6960
ttaatttcta cttagactag aatatggtac agatgctcaa aaatattgac ttaattaata   7020
attaaacaat taacaagtct atctctttcc taattattaa aaaaattatg aagtatttcc   7080
cttcaaaatt tcacagttta ctttgacata aataaataaa taccataaag tattttgaag   7140
aggaaaggga agggtggggc ttcaaacaca aaataatggc aggttttgta aaggggcaat   7200
tcactaaacc caataggatt ctcctgttgc tatttttttt tttttttttt ttttggtggt   7260
ggttggaggg aagggttggg tgtgcatttg gcctgtgtga aaaactggtg ggtagacaat   7320
gccatgctgt tctagatggg ctcattgcta taggaataga tagtcactga atttacttgc   7380
ataggggatg gggtataaaa tgtttcctta tagctcctta acatggaatt cagcacccct   7440
ctccccatca gccttagctc tctctgaatc ccaagggata tgtgttataa aaatagctgc   7500
catcataaat gagaaaacca tcaggacctg gtaaaacttg gcttcccaaa cagtcagggg   7560
tctgggcatg gcagccgact gagaaccttt ctatctagta caaggtaaac aagatttgcc   7620
aagacttgat caactgatcc agctccctat ctccaaacag aacctcatct gaatgctcac   7680
aggctgtgcc ccagaagtgt agaagtgtca tgttccctgg gcaggctgct gggcagcctc   7740
tctgttgaca atagaccaca cttttgctga cctaggactc atgttgctct ttaagactgc   7800
ttccttggcc aggcatgatg gctcacacct gtaatcctgg cactttgaga ggcccaggca   7860
ggaggatctc ttgaggccag atgttcaaga ccagcctggt caacatagta agaccccata   7920
tctaccaaaa atagctgggc atggtggtgc acacctatac tcccagctac ttaggagact   7980
gaggtgggag gattgctaca tcccaggagt tcaaggctgt agtgagctat gatcatgcca   8040
ctgcactcca gcctgggcaa cagagcgaga tcctgtctca aacaaacagt ttccttctgt   8100
ttgattcttg ctgaaaaatt gagcatgcca gagctagcaa ggctcttaga ggtggtctgg   8160
tccaatgctt taatttcata catcaagaaa ctgaagcaga gcagagtgac ctgcccaggg   8220
tctctcagcc attcatgctc agaaatgtat gggctcctgt gaaacatgtg gctcttaaaa   8280
gcactatcat atatttgaag gcagaaaata ggctaaacct tcagccttca gacttttcct   8340
ctccagagaa aatgacccca gtttcctcac tatggttgct gggagctaga ttcctgggga   8400
tctggcagtg tggaccacct agtggtggct agaggagcaa ataatatccc gcattccatt   8460
ttccactcac caatccctga ggggcagcct gctgggttat gagcccacag ggggagaacc   8520
ccaacgaatt cagagatgca tcatggacca gtttctctta aggggcctgg gtctactatt   8580
ttcagttcta cttcgagaga agtggcctgc aatatcctgc agatttcccc tccagggaga   8640
aaagcattgt gcggtgcaag gagcacaggc tttgtggaaa gaggcatctg gggttgagat   8700
cctggctctt ttgcttcctt gaacaagtta accaaatctc tgggcctctg ctggttaatt   8760
tataccatgg ggatcatcat ttctccagtg gggttgtgaa gagaatgtgg tgggatcttg   8820
tgtgtggagc atgacactta gcaggcatcc gggaatggca gcctcctccc tttctaaact   8880
ggggctttct gagggtgact tcagattcca caatgtcaac agcacaatgg catcctcata   8940
aggaaagttt gggttggggc tcctcaagca attctctact ctcatttggt acaaagaaaa   9000
aaattaagcc tcacaatttt cttggcacca gactgaacct caaacccagt cttcactttt   9060
actaaaaagc cataaacaga gaccaggagg gtaaaaacta ccagaagata cactggattt   9120
agaaaacagt aagctggatg tgaagccaaa agagagggag aaagcaacat aaaagaatgt   9180
cagattgaag aagaaatgga ttctggccac ctaaagaaga agggaagtat agaaaaggga   9240
agctgattgg aaacaatggg taatgatgag tgtccctccc ctaaaaagtt aaaaaataaa   9300
tgagcaggca tgagaaaagg aagtaggcca gaggaagtag accaggatca gccacggatg   9360
tgagtgggga attttacaaa tttctacttg ggtgtgaaac atgtgtacac tcaaagctct   9420
gtctaggttc accgaaactc tcccagctca aggccattta gtaaaacctt ggcttaactg   9480
aatagtgggt aaggaggcct gaggatggcc cagagaaggt ttaaattctt actggctgct   9540
gcactaagtt gtaaagtgca gccttagttg atgatgcctt tattagtgca acatcccaga   9600
atgcatgcgt cttacaaccc ttgtggatat gaaacccagc tgggtagaca ctgcaaagtc   9660
ttctcatttg attcttccac ttggtttcta gtgtccctca gggacaaagg aaagccatgg   9720
tccagtctaa gatgaaaacc aattagacct ctggcaggcc tttgaccacc ctgagggcca   9780
cccccaaggc acggccacac tcgcatctgc tgccaggagg ccctatctta ggctcagctc   9840
ccaaaccttg aacatcttgg aggatccaca aataggaggt acactcagct caggctcagt   9900
cttccttaaa aagcgccttg ctaaagctat caagttcact ggaatacttc tgcgaaggac   9960
acagcttcag cgatgtcaga ttttttatgt aaatggtgcc ttcacatgct ctggggcatt  10020
tggctaccaa gggcggtttg aactagctcc agcacacaga atacaagtct cttcagaacc  10080
aggcaaaacc ctatgttgcc caatgactcc tgctgtttct tgagatttgc acagaagaca  10140
gagctgcaat tacccacgct gatatctatt tcatgaccac atatgttcaa aagccacatg  10200
tgagaggtat ggttgaaatg agaggttgtg tttgccaagt tgtcttctga ctgtggagag  10260
ctggtgagcc tcttctcatc tcctggggct ccatattata gagctgacga atctcttttc  10320
ttgctccttg aagtctttca ttcacttatt tattaattca tttaacacat caggcaccta  10380
ctaacttctc agagttcaag gcttcctagc ctatgatcag aaaggacacc tgtgtgctca  10440
tgagcacccc tgggatcagg gtgactgata gggtgctgtc atcactacta gatgaaactc  10500
tttggaacaa aggtctagga tataatattt atccttctgc aaatattcat atggcattcg  10560
ctgtgtacca ggccttctgt tgaacattgg cctgcagagc tgaagaggac gtgggtcttc  10620
tcttaggaac tcctagtctt gggaaaaagg aatggggaag ggctgtaatg tgaagttaaa  10680
aaaaagtgct gaggccgaac acatctgggc cctcactgca gccctattgc acacacactg  10740
catcacctcg aacaagttat tcaccctctc tgaattcatc tatttgccca taaaaataga  10800
gatgatcctt ttatatgttg gctaccactt attatgtgca gcatgcttgt tattgtacta  10860
agttactcat tttttagttt ttcatataac tcatattttt gttgattttt attttaaaat  10920
tccaaacgaa ttaattaaac tattttccaa aatacgtagt atgtgtacat ggtaaaaaac  10980
atttccaaaa gtttaccata aaaactgtct cctttcccat atcctcaatc cttcagaatc  11040
cctctccagg gataattacc accaccagtg tattccttaa gagatattta aactttatac  11100
aaaatacgca cacatcattc ttttccacaa atgacagcat actatgtaca tggtacctca  11160
cctagctttt ttcacttacc agtatatctt agagattgtt gcatgacaga atatacagat  11220
ctgcctgttt ttgttgtttt tcccaagttt ccaagagcta gaaactgttt ggtttttaag  11280
cagctgcttg gtattccatt aattggactt atcgtgcttt gatctgtccc tagtgatgga  11340
cattggggtt gtttcccttc atttatattt gaagcttgtt gcagtgacag tgtacacact  11400
tgcttgagca tgtgtgtgtc tacgataaat cccaataagc aatttaaagt aatttaattc  11460
ttatgctctc aacaaaccta agaggttatt tttttagagg aggaagctaa ggctgttgtt  11520
ttgatgcctt tttaccactg gacttgggac tcaactgttt gatagtcatc gagtccttga  11580
ctcttctccc ctgccaggat ttggccccta agcccagggc ccgagtctcc tccatcttca  11640
agggagagtg ggaacagcac aggccttggc ctcagtcctg ctccccctgc ttctagctgt  11700
gggatgggcc aggtgcttca cccagctgtg cctcctgtga ggcacagtgt gtgcaaaatg  11760
gaaatgtgaa catgaagatc aaaaatgtcc ctcaatgacc agtgctgttc ctcagagtca  11820
cgtgggaact catagaaagc gatattggta ctgctctttc ctctgtagca tggtccagat  11880
ggctcatagc agggaccatg atatgctggg tgagcaccca ctgcatgcac ccactgtgcc  11940
agcactgaga gactcctgtg ggagccacag caattctagg gtcttcactg gggactctga  12000
gacagcaggg agctaggatg agggctgcag agtgttcgtc tgccctcact gagcagaccc  12060
cctggatggc agggagcagt cccaagccag atggatgccc ataaccagcc atttggctct  12120
caatacataa tatcaccacg tatcaggcaa aaccatcctg cccagagcat tatctgaatt  12180
tgcatcccat ctgcagaaga tacattcacc cacttcttcc attctgtctt aatcaaagtc  12240
tttatgtgaa ttttccccat tgagaagaca agccccttcc tggcttagac tgtacctgac  12300
tgatcttttc atgagctcct tgccaagcca gaccaccccc agcttatatg gagacttggt  12360
gcaaattaga gatgcccctg tgcacgtggc agccctgagc ccaagcaccc agtaaggcaa  12420
agggcctgat ttgggacccc tctgccactc caccaggcaa tcagttgctt atttctaact  12480
ttcccttcct tctccacatt tgtcccattc cttcctctca tcatgaatat ccccagaggc  12540
attcagcagt gcagtgaatt aaatatagaa cttttttttt tcagaattgc agaacggatt  12600
agatcaatat taatccaaac agagcaatga gcctgacagt ttagtaaaag ctcaataaag  12660
ggtggcttac ctcccccaaa ataatctgaa aagaaagcat gtcttatttc agggggaaaa  12720
aaaaataaag tgacctttaa agaccaaatt cccaggatac ccagggtgga ggtggaacat  12780
gggagtccac aggcagcctg gatgtttcca aagatccaaa gggcttttgc ttcctcacat  12840
aatgcaggaa acaaattgaa catgtattaa gtgcttgctg tatgtgacac actgtgccag  12900
gtgctcccct taaaacagtt ctgtgggcag gcatgagaat gaatcccgat cttacagaca  12960
aggaatgtta ggctcagagg tttcaagctc acccatcact cagccagaga ggacagatgc  13020
aggattcaat ctcgggagtg cccgagtcca cagaagttcc tgtgctgaag gaccgaccac  13080
aggcacataa agagatgcga gacaattttt actggatttg gccacctctc gaggtcggct  13140
ttgccagctc ttctcactgg gggaagggga gggagaaagt agctagctcc agggtcccta  13200
acatagaacc accaaggact tgactatttt tactcataca gcagcttgtc tgggaagatc  13260
atgctctgtg acaagctgca ggcactaagt agcaatttct gtttcccaca tattagcttg  13320
agtcatataa aactgacatg gatgtggctc aaaaatagct gtatgtcagc cattttatac  13380
catttgactt aaatgttatt aattaacgtc acagccagag attattctct gagaaaaggg  13440
cattgtagcc tgaagcagag aaagcataca cgttccctgg ggttgagaac tcatcacagc  13500
ctgagacagc ttaggttgta aagccccggc ccacttatcc caggagagtc tgggtgagat  13560
gcaggcccca aagcagaggc tgggaagcga gaagtgacac accctggctg ggtgggccct  13620
catcttggtg agacaccacc tgggtaaaac catcatggaa agggtgtagt ggggcgtgga  13680
aactccctcg gttaaagcgt gagctttgct gtaagttgtg gtaaggaggg aggcagtgac  13740
aaccaggagg cctgttttga gggtttctga gggacccatc tgtggtatca cgaggagacg  13800
cccagaggag ccgtgtgaaa gggctgcctc ccagccggct ctggagtgaa tgagcagcaa  13860
gtcctggctg cgaaaagaag gggagtgcag cctgcagaag tgtcttcttt tttcaattcc  13920
tgctcagaag gaaacaggag ataagaatag tggggaagtc caaaccaaag tgaactatag  13980
ggctggtaat cgtaggggga attagtcacc cggagactag cccagcagac taacggagcc  14040
ccatcctcca tcttgaatca gtcagcccct ctatgactgc agagtcctga atgatggcaa  14100
caccttctct tcacttagcg ttgtaggatg accaacagtc ctgatttgcc tgggactgag  14160
gggttcccaa tagatgggac tttcagggct aaaaccagga aagtcctggg cagcccaaaa  14220
caaggtagtc actctagagt gtatgactct gtctgatacc tgctaagaaa gagaaggact  14280
tgttgattat aaggagaaga ggaggtgaaa tggttctcaa aaaacaaaga tgagggcttc  14340
cgggtgctgt tctgcccaag gctctgggtc tgaggcttct ctctccaggc ctagcttcat  14400
ggaaaagtaa ggggccagag ggtggaaaag gtggaaacaa aggaagagga tggagaattg  14460
ctttggggaa gtttggactg gaagtgtgaa ttacagctgc acccccaatt caccccatct  14520
cacccccctc cccctcctgc tcatggttct ccctttctca tccacacatt ggtcaaacta  14580
gctagctttt ggagagattt tgggcagtaa aagtaaaaca gatctgtctc aagcttcaaa  14640
aagcctagag ctggctgggc gctgtggctc acgcctgtaa tcctagcatt ttgggaggct  14700
gaggcggaag gataatctga ggtcaggagt ttgagaccag cctggctaac atgatgaaac  14760
cccatctcta ctaaaaatac aaaaattagc caggcgtggt agtgcacgcc tataatccca  14820
gctatttggg aggctgaggc aggagaatcg cttgaacccc aggggacaga ggttgcagtg  14880
agctgagatc gcaccactgc actccagcct gggtgacaca gcgagactcc atttaaaaaa  14940
aaaaaaatgc ctagagccaa atgctcacag agccatttac tgcatggctt tgggcaagtc  15000
aaaggagtcc gcctctcctg tcagaagagt ctgttgcagt cttcatcaca agactgttgt  15060
ggggattaaa caagatggca agtgggaagt tgggaaatgt agtgtgcacc caaccaatat  15120
ttgtttcttc ctgcctgcct acatatgagg ccacacagaa ttccaacttt gtttctctga  15180
taactaacac agttacttgt ttttctttct gatccaggcc ttcaccatgg atcagttccc  15240
tgaatcagtg acagaaaact ttgagtacga tgatttggct gaggcctgtt atattgggga  15300
catcgtggtc tttgggactg tgttcctgtc catattctac tccgtcatct ttgccattgg  15360
cctggtggga aatttgttgg tagtgtttgc cctcaccaac agcaagaagc ccaagagtgt  15420
caccgacatt tacctcctga acctggcctt gtctgatctg ctgtttgtag ccactttgcc  15480
cttctggact cactatttga taaatgaaaa gggcctccac aatgccatgt gcaaattcac  15540
taccgccttc ttcttcatcg gcttttttgg aagcatattc ttcatcaccg tcatcagcat  15600
tgataggtac ctggccatcg tcctggccgc caactccatg aacaaccgga ccgtgcagca  15660
tggcgtcacc atcagcctag gcgtctgggc agcagccatt ttggtggcag caccccagtt  15720
catgttcaca aagcagaaag aaaatgaatg ccttggtgac taccccgagg tcctccagga  15780
aatctggccc gtgctccgca atgtggaaac aaattttctt ggcttcctac tccccctgct  15840
cattatgagt tattgctact tcagaatcat ccagacgctg ttttcctgca agaaccacaa  15900
gaaagccaaa gccattaaac tgatccttct ggtggtcatc gtgtttttcc tcttctggac  15960
accctacaac gttatgattt tcctggagac gcttaagctc tatgacttct ttcccagttg  16020
tgacatgagg aaggatctga ggctggccct cagtgtgact gagacggttg catttagcca  16080
ttgttgcctg aatcctctca tctatgcatt tgctggggag aagttcagaa gataccttta  16140
ccacctgtat gggaaatgcc tggctgtcct gtgtgggcgc tcagtccacg ttgatttctc  16200
ctcatctgaa tcacaaagga gcaggcatgg aagtgttctg agcagcaatt ttacttacca  16260
cacgagtgat ggagatgcat tgctccttct ctgaagggaa tcccaaagcc ttgtgtctac  16320
agagaacctg gagttcctga acctgatgct gactagtgag gaaagatttt tgttgttatt  16380
tcttacaggc acaaaatgat ggacccaatg cacacaaaac aaccctagag tgttgttgag  16440
aattgtgctc aaaatttgaa gaatgaacaa attgaactct ttgaatgaca aagagtagac  16500
atttctctta ctgcaaatgt catcagaact ttttggtttg cagatgacaa aaattcaact  16560
cagactagtt tagttaaatg agggtggtga atattgttca tattgtggca caagcaaaag  16620
ggtgtctgag ccctcaaagt gaggggaaac cagggcctga gccaagctag aattccctct  16680
ctctgactct caaatctttt agtcattata gatcccccag actttacatg acacagcttt  16740
atcaccagag agggactgac acccatgttt ctctggcccc aagggcaaaa ttcccaggga  16800
agtgctctga taggccaagt ttgtatcagg tgcccatccc tggaaggtgc tgttatccat  16860
ggggaaggga tatataagat ggaagcttcc agtccaatct catggagaag cagaaataca  16920
tatttccaag aagttggatg ggtgggtact attctgatta cacaaaacaa atgccacaca  16980
tcacccttac catgtgcctg atccagcctc tcccctgatt acaccagcct cgtcttcatt  17040
aagccctctt ccatcatgtc cccaaacctg caagggctcc ccactgccta ctgcatcgag  17100
tcaaaactca aatgcttggc ttctcatacg tccaccatgg ggtcctacca atagattccc  17160
cattgcctcc tccttcccaa aggactccac ccatcctatc agcctgtctc ttccatatga  17220
cctcatgcat ctccacctgc tcccaggcca gtaagggaaa tagaaaaacc ctgcccccaa  17280
ataagaaggg atggattcca accccaactc cagtagcttg ggacaaatca agcttcagtt  17340
tcctggtctg tagaagaggg ataaggtacc tttcacatag agatcatcct ttccagcatg  17400
aggaactagc caccaactct tgcaggtctc aacccttttg tctgcctctt agacttctgc  17460
tttccacacc tggcactgct gtgctgtgcc caagttgtgg tgctgacaaa gcttggaaga  17520
gcctgcaggt gctgctgcgt ggcatagccc agacacagaa gaggctggtt cttacgatgg  17580
cacccagtga gcactcccaa gtctacagag tgatagcctt ccgtaaccca actctcctgg  17640
actgccttga atatcccctc ccagtcacct tgtggcaagc ccctgcccat ctgggaaaat  17700
accccatcat tcatgctact gccaacctgg ggagccaggg ctatgggagc agcttttttt  17760
tcccccctag aaacgtttgg aacaatctaa aagtttaaag ctcgaaaaca attgtaataa  17820
tgctaaagaa aaagtcatcc aatctaacca catcaatatt gtcattcctg tattcacccg  17880
tccagacctt gttcacactc tcacatgttt agagttgcaa tcgtaatgta cagatggttt  17940
tataatctga tttgttttcc tcttaacgtt agaccacaaa tagtgctcgc tttctatgta  18000
gtttggtaat tatcatttta gaagactcta ccagactgtg tattcattga agtcagatgt  18060
ggtaactgtt aaattgctgt gtatctgata gctctttggc agtctatatg tttgtataat  18120
gaatgagaga ataagtcatg ttccttcaag atcatgtacc ccaatttact tgccattact  18180
caattgataa acatttaact tgtttccaat gtttagcaaa tacatatttt atagaacttc  18240
ca                                                                 18242


<210>  77

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T01

<400>  77
tctttcctct gtagcatggt ccagatggct catagcaggg accatgata                 49


<210>  78

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T02

<400>  78
tatgctgggt gagcacccac tgcatgcacc cactgtgcca gcactgaga                 49


<210>  79

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T03

<400>  79
tgctgggtga gcacccactg catgcaccca ctgtgccagc actgagaga                 49


<210>  80

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T04

<400>  80
tgagagactc ctgtgggagc cacagcaatt ctagggtctt cactgggga                 49


<210>  81

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T05

<400>  81
tcctgtggga gccacagcaa ttctagggtc ttcactgggg actctgaga                 49


<210>  82

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T06

<400>  82
tgggagccac agcaattcta gggtcttcac tggggactct gagacagca                 49


<210>  83

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T07

<400>  83
tcgtctgccc tcactgagca gaccccctgg atggcaggga gcagtccca                 49


<210>  84

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T08

<400>  84
tgccctcact gagcagaccc cctggatggc agggagcagt cccaagcca                 49


<210>  85

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T09

<400>  85
tggatggcag ggagcagtcc caagccagat ggatgcccat aaccagcca                 49


<210>  86

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T10

<400>  86
tctcaataca taatatcacc acgtatcagg caaaaccatc ctgcccaga                 49


<210>  87

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T11

<400>  87
tatcaggcaa aaccatcctg cccagagcat tatctgaatt tgcatccca                 49


<210>  88

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T12

<400>  88
tcctgcccag agcattatct gaatttgcat cccatctgca gaagataca                 49


<210>  89

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T13

<400>  89
tctgaatttg catcccatct gcagaagata cattcaccca cttcttcca                 49


<210>  90

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T14

<400>  90
ttccattctg tcttaatcaa agtctttatg tgaattttcc ccattgaga                 49


<210>  91

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T15

<400>  91
tccattctgt cttaatcaaa gtctttatgt gaattttccc cattgagaa                 49


<210>  92

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T16

<400>  92
ttctgtctta atcaaagtct ttatgtgaat tttccccatt gagaagaca                 49


<210>  93

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T17

<400>  93
tctgtcttaa tcaaagtctt tatgtgaatt ttccccattg agaagacaa                 49


<210>  94

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T18

<400>  94
tttatgtgaa ttttccccat tgagaagaca agccccttcc tggcttaga                 49


<210>  95

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T19

<400>  95
ttcctggctt agactgtacc tgactgatct tttcatgagc tccttgcca                 49


<210>  96

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_T20

<400>  96
tcctggctta gactgtacct gactgatctt ttcatgagct ccttgccaa                 49


<210>  97

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA1

<400>  97
gtacagtcta agccaggaag ggg                                             23


<210>  98

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA2

<400>  98
gggagcagtc ccaagccaga tgg                                             23


<210>  99

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA3

<400>  99
gactgctccc tgccatccag ggg                                             23


<210>  100

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA4

<400>  100
gtgaatgtat cttctgcaga tgg                                             23


<210>  101

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA5

<400>  101
gtctctcagt gctggcacag tgg                                             23


<210>  102

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA6

<400>  102
gacagcaggg agctaggatg agg                                             23


<210>  103

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA7

<400>  103
gaaggggctt gtcttctcaa tgg                                             23


<210>  104

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA8

<400>  104
gcaaattcag ataatgctct ggg                                             23


<210>  105

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA9

<400>  105
gagcagaccc cctggatggc agg                                             23


<210>  106

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CX3CR1_gRNA10

<400>  106
gaactcatag aaagcgatat tgg                                             23


<210>  107

<211>  1599
<212>  DNA
<213>  homo sapiens

<220>
<223>  CD11b_loci

<400>  107
gtgcatgggg gtggggtggg ggactctggg tggggaggag ggtaactttt gggtctgtca     60
taaatagagg gcccagaata tgtaggagtc agtctgggga gaggcaaagg ggatttgggg    120
aaggagaaag ggttcaagaa gaagcaggga gaacagctag acccagacag gctggccagg    180
gaagcctgga tgaatgacca cattcatgga ctgtgcaagg ctgcttgccg gtccccttgc    240
ttcacacatg aggagacgga ggcccaggga ggagaagtga catggctcag ggtgcgcagc    300
aggtgtgaga cccctttcct gagtgcttcc tcctggatcc cctctcacca tctccacttt    360
gcctccggtt ctattttcca aggtcccggg tgcaaatgtt tgttgaatga ctgatgaatg    420
aaaatgattt gagtttgtta ccttttatgc ttatatgttg tggaaaatga aattctcctc    480
aaaagggaag gaaatacttg agagctgcat aggaaggaaa ttatctaatt aagaatgtat    540
agaaacttca ctgttgggca aatcatcgtt gtgacaccgg gggaagaagc catttaggtg    600
ctcagaaggg aggctggaat tcagagcagg actggacgtg ccccacgacg gtggttctta    660
ggtcaggagt cagcaaacag tggcctgggg gcccgatatg gcccacgacc tgtttttgca    720
caacctgcca gctagagatt gaagatgaac actgataatc gatttgatga tagggagcac    780
cacccccaaa gaattctatt tgtctcattt gtaaacccgt attacaaaca aattgtactc    840
aatcattatg tttgaaattt ccctaatgac aaatttgtgg aaaagtattt tctgtcttgt    900
tatataagta cttgtacaac atattctatc agcctcttgg tctgcaaaac ctaaaattta    960
ctatctggct gtttacagaa taagtgtgct aatccccgcc ccaggctaac agagctggac   1020
ctgggaggca gacatctgga tgctgggtta gttagggtga ccgaatggat gggaaaggga   1080
atggagcagg aagacatgct gctatctttt tttttttttt ttttttttga tacagggtct   1140
ttctctgttg cccaggctgt agtgcagtgg catgatcatg gttcactgca gccttgacct   1200
cctgggttca agcaatcctc ccacctcagc ctcctgagta ccactacacc cggctaattt   1260
tttatttttt gtagagatgg ggtctcactg tgttgcctag gctggtctta aactcctgag   1320
cccaggtgat cctcccacgt cagcctctta aattattggg ataacaggcc tgagccacca   1380
cacccagcca ttgctttctt ttaaattatt attagttttt gttttttttt tgtatttaat   1440
tttgagatag gatctctctc tgttgctcag gctggagtgc agtggcacaa tcagggctca   1500
agtgatcctc ctgcctcagc cctccaaagt gctaggacta cagcccctaa ctggcatgct   1560
actttcctct gcttgatcct tcccccattc tccctttag                          1599


<210>  108

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T01

<400>  108
ttcagagcag gactggacgt gccccacgac ggtggttctt aggtcagga                 49


<210>  109

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T02

<400>  109
tatggcccac gacctgtttt tgcacaacct gccagctaga gattgaaga                 49


<210>  110

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T03

<400>  110
tgatgatagg gagcaccacc cccaaagaat tctatttgtc tcatttgta                 49


<210>  111

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T04

<400>  111
ttctatttgt ctcatttgta aacccgtatt acaaacaaat tgtactcaa                 49


<210>  112

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T05

<400>  112
tatttgtctc atttgtaaac ccgtattaca aacaaattgt actcaatca                 49


<210>  113

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T06

<400>  113
tttgtaaacc cgtattacaa acaaattgta ctcaatcatt atgtttgaa                 49


<210>  114

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T07

<400>  114
ttgtaaaccc gtattacaaa caaattgtac tcaatcatta tgtttgaaa                 49


<210>  115

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T08

<400>  115
tacaaacaaa ttgtactcaa tcattatgtt tgaaatttcc ctaatgaca                 49


<210>  116

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T09

<400>  116
ttgtactcaa tcattatgtt tgaaatttcc ctaatgacaa atttgtgga                 49


<210>  117

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T10

<400>  117
tgtactcaat cattatgttt gaaatttccc taatgacaaa tttgtggaa                 49


<210>  118

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T11

<400>  118
tactcaatca ttatgtttga aatttcccta atgacaaatt tgtggaaaa                 49


<210>  119

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T12

<400>  119
tttccctaat gacaaatttg tggaaaagta ttttctgtct tgttatata                 49


<210>  120

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T13

<400>  120
ttccctaatg acaaatttgt ggaaaagtat tttctgtctt gttatataa                 49


<210>  121

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T14

<400>  121
ttgtggaaaa gtattttctg tcttgttata taagtacttg tacaacata                 49


<210>  122

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T15

<400>  122
tgttatataa gtacttgtac aacatattct atcagcctct tggtctgca                 49


<210>  123

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T16

<400>  123
ttatataagt acttgtacaa catattctat cagcctcttg gtctgcaaa                 49


<210>  124

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T17

<400>  124
tatataagta cttgtacaac atattctatc agcctcttgg tctgcaaaa                 49


<210>  125

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T18

<400>  125
tacaacatat tctatcagcc tcttggtctg caaaacctaa aatttacta                 49


<210>  126

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T19

<400>  126
tcttggtctg caaaacctaa aatttactat ctggctgttt acagaataa                 49


<210>  127

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T20

<400>  127
tgcaaaacct aaaatttact atctggctgt ttacagaata agtgtgcta                 49


<210>  128

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T21

<400>  128
tgaaaatgat ttgagtttgt taccttttat gcttatatgt tgtggaaaa                 49


<210>  129

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T22

<400>  129
tttgttacct tttatgctta tatgttgtgg aaaatgaaat tctcctcaa                 49


<210>  130

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T23

<400>  130
ttgttacctt ttatgcttat atgttgtgga aaatgaaatt ctcctcaaa                 49


<210>  131

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T24

<400>  131
tgttaccttt tatgcttata tgttgtggaa aatgaaattc tcctcaaaa                 49


<210>  132

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T25

<400>  132
tttatgctta tatgttgtgg aaaatgaaat tctcctcaaa agggaagga                 49


<210>  133

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T26

<400>  133
ttatgcttat atgttgtgga aaatgaaatt ctcctcaaaa gggaaggaa                 49


<210>  134

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T27

<400>  134
tatgcttata tgttgtggaa aatgaaattc tcctcaaaag ggaaggaaa                 49


<210>  135

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T28

<400>  135
tgcttatatg ttgtggaaaa tgaaattctc ctcaaaaggg aaggaaata                 49


<210>  136

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T29

<400>  136
tggaaaatga aattctcctc aaaagggaag gaaatacttg agagctgca                 49


<210>  137

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_T30

<400>  137
tacttgagag ctgcatagga aggaaattat ctaattaaga atgtataga                 49


<210>  138

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA1

<400>  138
ggttgtgcaa aaacaggtcg tgg                                             23


<210>  139

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA2

<400>  139
gggaggctgg aattcagagc agg                                             23


<210>  140

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA3

<400>  140
ggagtcagca aacagtggcc tgg                                             23


<210>  141

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA4

<400>  141
gagtcagcaa acagtggcct ggg                                             23


<210>  142

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA5

<400>  142
gacctaagaa ccaccgtcgt ggg                                             23


<210>  143

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA6

<400>  143
gcaaatcatc gttgtgacac cgg                                             23


<210>  144

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA7

<400>  144
gagacaaata gaattctttg ggg                                             23


<210>  145

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA8

<400>  145
gccccacgac ggtggttctt agg                                             23


<210>  146

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA9

<400>  146
gaaatacttg agagctgcat agg                                             23


<210>  147

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  CD11b_gRNA10

<400>  147
ggtcaggagt cagcaaacag tgg                                             23


<210>  148

<211>  387
<212>  DNA
<213>  homo sapiens

<220>
<223>  S100A9_loci

<400>  148
gtaagtgagc tgccagcttc cccaggcaga agcctgcctg ccgattcctt ctttccttcc     60
ctgacccaac ttccttccaa atcctcctcc tagaagccct ccttggttgg ccctgcctac    120
tttaaagctt ctttcacatt ttcttaggtc atgttcccct ggggcctcct gccctcaaat    180
gctttgcttt ttggcactct gtagatattc taaaaaatca ttttgtacat gtgtgtgaca    240
ggccatctcc cagttaagtt gcagcctgtg ctttcttttt attttgcact tcccccacta    300
tttctgtgag tgcttagtag gaagtgtcaa agaagcttga cagcattttc ttctaagtgt    360
cccaactctt ggttttccat tacacag                                        387


<210>  149

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T01

<400>  149
tttccccgtt gtattggttg aaataagttt cactaattgg taacctcca                 49


<210>  150

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T02

<400>  150
tattggttga aataagtttc actaattggt aacctccaga gggaaggga                 49


<210>  151

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T03

<400>  151
tttcactaat tggtaacctc cagagggaag ggaagggagg gcaggggaa                 49


<210>  152

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T04

<400>  152
tggaactggc ctctaagtca gatctgaatt tgcatgccct caatagtca                 49


<210>  153

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T05

<400>  153
tctaagtcag atctgaattt gcatgccctc aatagtcaag ctgtgaaaa                 49


<210>  154

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T06

<400>  154
tgcatgccct caatagtcaa gctgtgaaaa ctaatgaccc tctctagga                 49


<210>  155

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T07

<400>  155
tgaaaactaa tgaccctctc taggactggt ttcaagtctt cctccagga                 49


<210>  156

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T08

<400>  156
tcttcctcca ggaagatacc attcctagct gttaaagttg ttataagga                 49


<210>  157

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T09

<400>  157
tcctccagga agataccatt cctagctgtt aaagttgtta taaggacca                 49


<210>  158

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T10

<400>  158
ttcctagctg ttaaagttgt tataaggacc aaatgaggtg acatttcca                 49


<210>  159

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T11

<400>  159
ttaaagttgt tataaggacc aaatgaggtg acatttccag gcttactca                 49


<210>  160

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T12

<400>  160
tgaccagggc aagaccctgg aactcagctt cctcttctat aaatagaga                 49


<210>  161

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T13

<400>  161
ttcctcttct ataaatagag aatcagcacc caagtcacag ggtcatgga                 49


<210>  162

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T14

<400>  162
tcttctataa atagagaatc agcacccaag tcacagggtc atggaggga                 49


<210>  163

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T15

<400>  163
tctataaata gagaatcagc acccaagtca cagggtcatg gagggaata                 49


<210>  164

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T16

<400>  164
tataaataga gaatcagcac ccaagtcaca gggtcatgga gggaataaa                 49


<210>  165

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T17

<400>  165
tggagagcgt ttggtatgtg ctcagtgtct gctccattgt gcgcactca                 49


<210>  166

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T18

<400>  166
tggtatgtgc tcagtgtctg ctccattgtg cgcactcagc ctatggtca                 49


<210>  167

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T19

<400>  167
ttgtgcgcac tcagcctatg gtcattttta atttttaaat ccagcccca                 49


<210>  168

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T20

<400>  168
ttcccttgta catttgccag ctggtcattt actgtgctcc cagtcccca                 49


<210>  169

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T21

<400>  169
ttttgttttc ttttcaaatt tggggaaagt cgggaaacag aggcctgca                 49


<210>  170

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T22

<400>  170
tttcttttca aatttgggga aagtcgggaa acagaggcct gcattaaga                 49


<210>  171

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T23

<400>  171
ttcttttcaa atttggggaa agtcgggaaa cagaggcctg cattaagaa                 49


<210>  172

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T24

<400>  172
ttggggaaag tcgggaaaca gaggcctgca ttaagaaggg tggaacaca                 49


<210>  173

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T25

<400>  173
taggtcccca gccctcccag tgcccctccc tccgccttgg taaggtgga                 49


<210>  174

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T26

<400>  174
ttcagagtta ggggccctga cagctctcca taggtggagg cctcaggca                 49


<210>  175

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T27

<400>  175
ttaggggccc tgacagctct ccataggtgg aggcctcagg caggcagga                 49


<210>  176

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T28

<400>  176
tccataggtg gaggcctcag gcaggcagga tgctgggtgg ggtaggcaa                 49


<210>  177

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T29

<400>  177
taggtggagg cctcaggcag gcaggatgct gggtggggta ggcaagaaa                 49


<210>  178

<211>  49
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_T30

<400>  178
tgggtggggt aggcaagaaa gggcccagca gagaggccgc atggcaaaa                 49


<210>  179

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA1

<400>  179
gcacaggaga gtgctcgcat tgg                                             23


<210>  180

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA2

<400>  180
ggtaccccac aggttctggg agg                                             23


<210>  181

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA3

<400>  181
ggagccagac atcctggggt agg                                             23


<210>  182

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA4

<400>  182
ggagagtgct cgcattggct ggg                                             23


<210>  183

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA5

<400>  183
ggaagcagag cctcatggat ggg                                             23


<210>  184

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA6

<400>  184
ggcttactca tgccatgacc agg                                             23


<210>  185

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA7

<400>  185
gggaaacacc tagaaaaact agg                                             23


<210>  186

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA8

<400>  186
gtggggggtg aagcgggcat agg                                             23


<210>  187

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA9

<400>  187
ggggggtgaa gcgggcatag ggg                                             23


<210>  188

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  S100A9_gRNA10

<400>  188
gagggctggg gacctacccc agg                                             23


<210>  189

<211>  3424
<212>  DNA
<213>  homo sapiens

<220>
<223>  TMEM119

<400>  189
gtgagtcctg gggtcccctc ctctgtcctg agagcctgga gctatcttgg agcttaggga     60
ctggggactg ttggagcact ctggggggcc tctctaagtg tgtgtgggct ttgagtgtgt    120
gtttggtgtt gtgtgcatga gtgtggtgga atctgagtcc cgtgtgcggt gctggggtgg    180
gccagggtgg gccggagtgt tgtgtgtgtg cggctggggc cttggtgtag ggggtgtgtt    240
gcttccactt ttctgcaagt ggatgccagg ctgttgcttc caggatctgt gtgagggtga    300
tgtggacggt attgtcctgt gtgcagggat cggctgtgtg tcagggggtt gtgtatgtat    360
atgtgttgtg tgtccgtgtg tgttctctgt gtattgtgtg catgggccat gagagtgctg    420
ttgggtgtct cagtgctgtg tgagtcggtg tgcctgtgtt gtgtgtcttt atattgtgtg    480
tccatgctgc tctgtgtgtg tgtgtgtgtg tggaggggga ttgtgccccc aggacccccc    540
tccccatcca gacctccagg gcccaggtcc ctgtccttgg ctggccctgg ggtcgggggc    600
atgtgcagtg ctccaaccag aacacccctc ccccacaagg ccactgattg aagccaggtt    660
tccgtgggcc gcccctcccc caaaggccac cagtctctgg gtgggggtgg ggcagccccc    720
ggtcccctag cttcaagtct tggggccccc aggcctcagg ggtgcatctg cactcctcca    780
cagactcagg accatcttag ggcatttgcc acacttacac acggccagcc ctgcctgaca    840
tgtccccagg cagggagtcc tgggcaatca cgtggtacct gctaattggc acccactgtg    900
caccaggcat ggccgcatct tgtcctaaca gcagtccagg gaggtggctc ttatccccat    960
tgtacagata tggaaaccga ggctcagaga ggtgacatgc ccagcccaag gacacatagc   1020
cgggaagtga cctcctctgg gatataccaa gacaggcttc tctgtccagg gctctgctgg   1080
gctcacccct gactttctgt gtgacctggg caggctgttt ccagtctctg gacctgagtt   1140
acctctaagg tgaagcaaga ggcgttgggc ctgaccccag ctcctaatgg cctgttagat   1200
tctgagtcct tgaaaaaatt agggtccggg gggaggtagg cagaataatg acttcagagc   1260
tgcccagaac agtgcttcat tccacagatg ggaaactgag gcccagagag ggcaggggcc   1320
gtccagggcc acacaaccat cttttttgag gctctgctga ctgcaggtgg ggctgggtcc   1380
tccatacgtt gcccccacct ttccctggaa gccaggaggg gttgtggggt gcaggggact   1440
ctgagagtca gggtctcagc cttaaagagc cagtggcagt ttgtgtgttc tcctttcttg   1500
ccctctgcct ctgacttcgt gtgtgtgtgt gtgtgtgtgt tgtatgtata tgtgtgtgta   1560
ggtgtatgtg tgcatgtgtg tgtatgtgta tgtgtgtgca tgtgtgtgtt tggttctgca   1620
ttccttggcg gccagagcta aagaggtttc actgaacggg gtgaaaaggt tggtctttca   1680
ctgggtggcg gccggaccag acagtgagcg catgttccca tccggcgatg gtgctcattt   1740
gtcgactcag ggtgggaaat tgctggctga acctggagtt cggctaggga aggaattcag   1800
ctaccccaga ccctatcttt cctcggggct cagctacttc gcaccaggca ctctctgaaa   1860
gttgtctcat ttggccctaa cagctctgag aggtgctacc tgtggtcacc ctgtcccaac   1920
ttacggatgg ggaaagtgag gcccacagga gccagaccac agagctggat gcgatggagc   1980
cgggattctt gacccagcca gaacttgagt gggtctccag ccacccatgg tcccagctgc   2040
cctctgcagt gagaagtggt agttgttgcc acaaaagctc tctcctaggc ttgactgggg   2100
gtgggaggca gggaggtgac tggcaggtca cagaccccaa agctcaaggt tgtctgtagg   2160
aacctttgct aacaggtgcc agagaggtga gggggtcctt tcctcattta gcatctgaca   2220
ggtgatgtcc accagcggga acaagccatt cctggctcag agtgtgtggt gtgtgcatgt   2280
gtgtgtggtt gtgtaggtga gtgtgtgtgg tgtatgtgta tggttgtgtg tatgtggagt   2340
gtatgcatat atgtgtggtg tgtgcatgtg tgtatgattg tgtgtagtat gtgaatgtgt   2400
gtataggggt gtgtgtgggg catgtgtgta cgtggttgtg tgtggggtgt atatgggtat   2460
gtgtggcgtg tgtgcatgtt tgtgtgtggg gtgtgtgtgc atgtgtgtag atgattgtgt   2520
gtgtagtatg tgcatgtgtg tatatgggtg tgtgagtgtg tgtgtggtat gtgtgtgcat   2580
ggttgtgtgt ggtgtgtgtg catgtgtgta tgattgtgta gtctgtgcat gtgtgtatat   2640
gggtgtgtgt gtgtgtggcg tgtgtgcatg attatgtgtg gggtgtgtat ggggatgtgt   2700
gtgtgagtgt gtggcgtgta tgaatggttg tgtgtgtggt gagtgtgcat gtgtatgtat   2760
ggctgtgtat gagtgtgagt gtggtttgtg tgaatgtgcg tgtaaactcc tgggatcaga   2820
cagaggaagg ttcagatccc agctcagcta cttatcatct gtgtgtcctt ggggaagtca   2880
ctgtctgtct ctgaacctct gtttcctcat ctgtaaaatg gggataatga agctgcctca   2940
gggctcctgt aggattaaag gcatgaaaag ggcttagatg agtacccgcg aggaaagcac   3000
aggtgaccag ctcatttaaa atgagcccct gagaagcttt gtctcttttt taaaaaattg   3060
aaatatttta atatatttca tagagatgga ggtttcctta tgttgcccag gctggtcttg   3120
aactcctggg ctcaagcgat cctcccaagt agctgggact acaggcatac accaccaggc   3180
ctggctactt ttttattttt ttgtagaggt ggggtcttac tatgttgctc aaactcctgc   3240
cctcaatcaa tcctccggcc tcggcctccc aaagtgctgg gattacaagt gtgagccacc   3300
acacctggcc aattttgcct ctttttatgt cctggaatta tttttttatt ttttccatct   3360
aagccagttt gttcacattt aatttctttt ttttcttttc tttctttctt tttttttttg   3420
acag                                                                3424


<210>  190

<211>  6273
<212>  DNA
<213>  homo sapiens

<220>
<223>  MERTK

<400>  190
gtgagtgcgc ccggctgggg gccaggcgag ggggtggggg ctcccaggag gaagcagggg     60
cctctgggga gggagcgcgt ccacaggggc gcgcctggct gctggacaag tttgcaaaca    120
ccctccaccc actgcggtgc cagaggaggg ggcgtaggcg aacctaccgt ccactgaccg    180
cggcgcctca agcgtcccga gggcacccag cctggcttgc gggtgcgcat cgtggtgaag    240
ccgggtcggg gtcggcgttg caggctcccc tcttcaccgc agaggaggaa atcgagctcg    300
gccgggcgcg ctgcaagtcc tgaagttccg acgagtggaa cgtaggtagc aggtctggtc    360
tgggatgcga cgagaacttt ccactagagt tgcatggtgg ggccccgctc tggccggagt    420
cccgggggcc acagatccgg tctcccgagg gaccggcgcg gggcgaacga acgggctgcg    480
ggagtcggag ccgcagtccg ggagccgcga tagactgagg ccgagcgacg ggccaggggg    540
ggacggcagt cctggctgct cccaatgggc ccttacgggc attattagta tcccttttta    600
ggggcaccca gagagtgtgg gaaaagggga gcgttctttt cactcctgtt atggcagaac    660
agaacttaca gtgctcggca gcgtttacgt ttatctggat tcagcgaagt gttgttacag    720
gctttttttt ttttaatttg agaccgagtc tcgccctgtc gcccaggctg gagtgccgcg    780
gcgcgatctc ggctcactgc aggctccgcc tcccgggttc aagcgattct cctgcctcag    840
cctcccgagt agctgagact atagacgcgc gctaccacgt ccggctaatt tttgtatttt    900
tagtagagac ggggtttcac catgttggcc aggatggtct cgatctcttg acctcgtgat    960
ctgctctcct tggcctccca aagttctggg attacagtcg tgagccaccg cgcccggctt   1020
gttccaggca ttttaataca agatgctgga ctgatacgtg gaggcaagga aggccggttt   1080
cattctgctt gaacagctta tttggggagt gagtgatgaa cagatttcaa gtttgatcgc   1140
tgatgcactt cttgaggagg ctggaataaa cttaccaggc tttacccaaa agaaaaagaa   1200
aggggaaaaa tgctaaataa acacattcca agtattttct ctcagctaaa aggtttctat   1260
ttccattcag catgtagatt ttctctcttt tgatcgagaa tgcacttgac tagccttcac   1320
ctattacagt caaagatgtt ttttaggaat acctggaaag ctcagtttat agtcaagtaa   1380
gttacttaaa agtttttcct ttgagatttt cctttgaaag ctcatttact caaatgaaaa   1440
attcttaaac agtgcaccca ctttttgcac gttaaattac ataagcaatt tataatttgg   1500
ggcaacatag caatttgaaa caaactttaa gagccaggca aagaactaaa gcagttctgt   1560
tctccactgc ccctccctcc accaaacctt caaaaattcc tcagcatttc tgccagcccc   1620
atttttcata atctgctgca aatctgttat ttgttgctac tagtgaggac tggccgtgaa   1680
tagtcttgga ggtagtgaat gtggtgagaa ctatggagaa agtaatggga acaatagttt   1740
tgtgttaaat acttaaaaat tggagtgctt ttgtttttct aaaattttaa aaggctgtaa   1800
taacaaattt ttgtagctga caatcaactt taatcagaca atcataaaaa ggccttttaa   1860
aatccaccca gctggaagaa tgaaaagttt caccaatcgt tcttgcactt tttgcttttg   1920
gttttgaact ttacctatga gatgtgtgac agttttacat ctcaccttgt gaaaagctta   1980
aagaatggga ttctcactgg cagaattaca gcacaaagga gtgctgtatg aagaaattaa   2040
acatggaaat tagactcttc atctaatttt aagattttcc tattacacat tgtgggtctg   2100
agtgctttgc tgaccacaca ggggagacag agagagagac aatgagaata tgtgtgtaga   2160
ttctacactg ttagcagtat agaagaatgg gtaaataaaa tttaagcatc actttaaccc   2220
aggaaatccc ctctgccccc caacacacat acacactaca cgtctcacaa agacatgcac   2280
acacagaact ggaactgcca aaccaggagc atttcgaggc tttccagtct ttcctttctg   2340
ctcagtctct gatgggggtg ccattgagca gcaaaatgag gcaagcggtg gctctctgaa   2400
gggccaggga gaggatggag caagataaat ataaatgtgg ataaaaatga atgcattatg   2460
aggacttagc tcatgacgag gctgtgtgtg cagctaaact caacccttag agtaaattag   2520
gcttttaaga ttctttaatg ttaatatttc ttttccaaac tgatattgta acatgtattc   2580
cagtatattg taaacatctt cccagaggga acttttaagt tgttctgttg cttgtgggct   2640
ttattccaaa ggcttcaaat gctttttgaa agtacatcgt gcatatttta aaaatgaata   2700
cttttagaaa attattctga cccattaaag tgctgagtgg aattcttttc ttttctttct   2760
ttcttttttt tttttttttg gcaggttctc attctgccac ccaggctaga gtgcagtggc   2820
accatcacgg ctcactgcaa cctcaacctt ccgggctcaa gtgatcctcc cacctcagcc   2880
tcccaagtag ctatgaccac aggcacatac caccatgcct ggctaatttt ttattttttg   2940
tagagacagg atctcactat gttgcccagg ctggtcttga actcctgggc tcaagcgatc   3000
ttcccacctt agcctctcag agtgtgggga ttataggcat gagccaccat gcacagctga   3060
atacaatttt taaaaaatta acaataatta tgtttttttg tttttgagat agagtttcac   3120
tcttgctgtc caggctagag tgcaatggca caatctcggc tcaccgcaac ttcccgcctc   3180
ccgggttcaa gcagttctcc tgcctcagcc tcctgagtag ctgggattac aggcatgcac   3240
caccacgcct ggctaatttt gtatttttgg tagagacagg gtttctccgt gttggttagg   3300
ttggtctcga actcccaacc tcaggtgatc tgcctgcctt ggcctcccaa agtgctggga   3360
ttacaggcat gagccaccac acccagccaa taattatatt tttaaatctt aatttttgaa   3420
ataatttcca gataattgta gaagggccag tgagttacta gtcagcattg gtcaagaaga   3480
ggttcaatct ttttatgcct gtgaattggg aacatgctgc tgggtagaaa aactgagctg   3540
ggaccttgaa cacacatgtg aaacagtcgc tttccatata atagccagaa tgagattttg   3600
gaaacgaatc tgattgtatt ttccatttga aaatcttcca gtggcttcct gttccctact   3660
agaatttgca gagactcaca gcgaacctct ttgacccatt tccattcact tccctcttgt   3720
tcctaccact ccagccacct gtgtcttctt tctagggcct gagcagcctt tgcagtgact   3780
cttccctctg gctggaacct ttttcccaag atctcggcat gctggcttct tctcatcctt   3840
tgggtttcag ttcagaggtt ctccttgaga agccttcccc aataaccacc ccctgccaaa   3900
gtatcatatg catacacccc actatccctt aaatttaatt tcctgataat gcttctcaca   3960
acctgatcag ttccttcctt ccttccttcc ttcctccctc cctccctccc tctatttctt   4020
tattgacaga gtcttgcaat ggcaaattct ctgctcactg caacctccgc ctcccaggtt   4080
caagcaattc tcctgcctca gccttcccag tagctgggat tacaggcacc tgccaccaca   4140
gctggctaat ttttgtattt ttagtagaga cagggtttca ccatgttggc caggctggtc   4200
tcgaactcct gacctcaggt gatccgccta cctcagcctc ccaaagtgca gagattacag   4260
gcgtgagcta tggcacccag ccttacctct ttgtttactc cttttcctcc actgtccccc   4320
caccacaagg taagctcctg gtggcagggc tgctgtcttt ttcactgcta acacagcatg   4380
gagctcatac gggtgctcag tgagtatcag agcacagcat gaaggaacca agcccctgca   4440
tgtcttacca ggtgctcttc acccttatct tttcctactg gcttttccag aaacagaatt   4500
gctggagctc ccatgccctc acattcgggg cttggttaat agaaaacaat cttttatttt   4560
gctgtgatgc caatgtgatt tcattgctgg aggagctagt caattaaaac cagacagatt   4620
tttgggctgt attaacccca aacatatttt acattgtcct aactattcca actagaaaaa   4680
aaaatgtcag aaggtaattt ttcatgttaa acacagttct aacaactcct tgctcagggg   4740
caggtagccc tgggtgcctt gactttggcc cttgccgtta gtttaatctt aacccaaagc   4800
acatggctct gaattggtat gtttctcagc aggagattaa ttattataaa aactgaaagg   4860
ggtctcacac tgtgtgaggc acactatgcc tctggggact ggaatgaaag tgttaaccgg   4920
gactggcttc tggggctttg ggggtggtga ttaactttca ggacctctgt tcctttttgg   4980
gtacagtggg aggctctttt catagaattg ttaggaggac gtaatgagct aatggcaggt   5040
gatatgtgct taaaatatat ttgccattat taccaatggt tctcctccat tcttctgaac   5100
tcaagtatgg gggaaatgtt tttcctagac aaaaggtgtt gggaggaggg ttcttttctt   5160
attgaagtgt atcctgaatg gtccaccctc cattgttcag aatgctttgg tgaaggggcc   5220
ctccggtgtc gccctagagt gcccaagtcc tttgctgcag ctctttaggt ttttgtttcc   5280
tagtagtttg agcaaaaccc acccaggacc aagcagttct ccagagaagc agggcccgcc   5340
ctgactgcca ttcccctcct actcctgccc ccataccttc ccttatggag ttcaaacttg   5400
acatagtaca ggaatagctt cttgtcatgt gcctctcagg aaggtataaa aatgaagtcc   5460
agttcctgtt caacttttcc cacataactc ttttccaaac tgggtgtggt ttaaattttt   5520
ttatttttat tttttgtgtt tgttttgttt tagggttttt gagtgtgaac atccagaaaa   5580
ttcttttttt tttttttgag atggaatctt gctctgtcgc ccaggctgga gtgcatgtgg   5640
cgcgatctcg gctcactgca acctccgcct cctggcttca agcaattctc tgcctcagcc   5700
tcccaagtag ctgggattac aggtgccctc caccagacct ggctaatttt tgtattttaa   5760
gtagagacgg ggtttcaccg tgttgggcag gctggtcttg aactcctgac ctcgcgatcc   5820
acccacctcg gcctctcaaa gtgctgggat tacaggagtg aaccacctca cccagctcag   5880
aaaattcttt tcctttttac cacatcgagc taggttttcc caatgaggtc agttggctgc   5940
aacatagaga aaatgaggct ttggttctta gagtagattc cgtgtacagg cgtgagtatg   6000
tgtccgcagg tggtcttgta ggaaatgcaa agggcgccag gtgcactcct ggcttctggt   6060
acttcctgct taatggcatg ggtgagccaa ccctcaggtg cccgggaggg agccctgatt   6120
actctccctc tggcactctg ggcattggct aacccgtgac cggagttaaa ccagttccct   6180
ctcttttcat tctatgtctc ccactcctgc ctccagccga agtgctaaaa atgcagcctg   6240
gcaggggcag agaattccat taggatcagc agg                                6273


<210>  191

<211>  2541
<212>  DNA
<213>  homo sapiens

<220>
<223>  CD164

<400>  191
gtgggcgcgg gccctgtggg cttcccgccc tcccctgccc agccgagccg cactgcctcc     60
tcgccgtgcg ggcggggccc gggttcgggc cacggtcggg cgggcgggcc gcgctcgggg    120
tgcggcggcg actccggcaa catggcggcc agcctggagt ccactcgtgg ccgggccggg    180
tggggagcgc gctgggggga agcggacgcg cggttcccag tggctgcggg gctggggccc    240
ccctcgaagt gttgcaagtc gaggtgcctt ttaaaagtgc atcgtaattc ctagcctcac    300
ttggggtcgg aaatggggac gtggcttcct tccgcggggg cagcggtggg gttgaggatg    360
gggccgggcg tcgcgcctct gaggttggcg gtggggccga gctgcctctc cctgccactg    420
gttgttcacc ctcccggcgc ctctctccgg aggtagcctt ctccggaagt ccgggaaaga    480
gaaacttaaa gacggtaatg ctcgttcgtg tctcagactt gagtctgaga aggtcgcttg    540
agatttaatt acattggttt tgcagatagg aatagaatgt agctgacgtt tgagcacgta    600
gttagtgaaa acttcacact tcaaagtatg cgaaaaggaa gaaaagtacc catgtatgta    660
ccgggtgttt tgcgtacgta tcctaaggct aaactggaag gtaggtagtg aaacctagga    720
ggtagatgca gagacggaga tgagtaaact ctcctgacat tgtatgttta ttcttttttc    780
aattgttttt aaaattttct taactatgtc ctgtgctcag atagcgtatg tttagtaggt    840
cgtggaacgg gggtttgtgc ccaggtctgt gggttttcta aaacccgatc aggagcgtgt    900
cttttgttat gtgcagtcgc atagggctgg ttaaggcata catacatttt aaagcagaaa    960
ttgccatata ccgtgacaac acaaaagaga gaaggaagat aagtttgagg taataagcgg   1020
gagaaacact agaggtttaa aacctgcagt ctcgtatgat tggttattct agttaacatt   1080
agttaaggag taatgtttac gtagttaaca ttggcttctt gaccgaagaa tgccgaagtg   1140
taatgatttt tatcacggca ttcatattct acaaattctc ctctagtttt agtattttat   1200
aaaagtttaa taaagtatat agtaaactta atgttttgtt tttagtttaa ggaagatgta   1260
atggtaacat ttcaaaacga gggaagtaaa ttgcagtata atactgggaa ttctaaccgc   1320
actattttaa gatgatagag cagaatatgt ttgtctcagt cttaatttga cagtttcctt   1380
tcagaattgt agtgtgtgtg taagagaagg ttggaagtat caaattaatt tgtctttgtg   1440
taattgaagt gcgtgcaaag gaggtatgta ttttctggaa atcataagtg gatgtagtgt   1500
ggtctgaaag gtagcaagtt tagttcattg taaagaacat ttcagacatt tcactttgct   1560
acacccgtca agcacaaagg tttttaaaca gcatgtttta tctatacaaa cttcagaaaa   1620
tttattttta ctttatgaac ccttccccac cccaccgtac atgtcccagt ctttaataag   1680
tactaatgat gaagtattga aagcagtgcc tctgcagaac tattttttag gcaggagcaa   1740
agcaaacgag aatgtttgga ggcatctagt ttctaggaaa atgaatggag cccaattctt   1800
ttttttcttt tattttgctg ctttttctca ctggaaaata gagcccaatt ttatagtccg   1860
ttcttctcca gaaattgaat tatggtgatg agtacttgtt tctggattgt ttggcctagg   1920
atgaactatt gacaaatacc ttgttaacct gaattgtatg cacttgaata tgggctttta   1980
gatgttgtct ccagttgtgg aggatcctgt cgagagtgga tcatttatga atcgagaatc   2040
cctgggaaat tatctttgtt tgcagcagaa tgggcatcat cagtgcttgg gttcaacctg   2100
ttaaactact actgttacta ctaaaaatct cagggtttta tctgatgttt gggggtagtg   2160
gttttcctat gtgtagtgtt ggtattatat caaagccttt ttctcgatat ttttatgtat   2220
taaggatgct ttgaaatgcc taaatcctta gtggctgtgg gtgtcttcca atagttgtcc   2280
tgtgaaaaag gattggttag acagatacca tcaggcactg tactgagagt gaccactagc   2340
ttgtttttct aatgcgttta cttacagctt tgtaatgatt ggaatttctt agtaaaccag   2400
tataaagttt tatcatttat ctgaattagt aattttgatg ctgtatgtaa tgcttattgt   2460
tcaaaaagat aagtaataca gattcaaata agatactaat aaaatcattg atttcatgca   2520
tctctccccc caactcccca g                                             2541


<210>  192

<211>  357
<212>  DNA
<213>  homo sapiens

<220>
<223>  TLR7

<400>  192
gtattttaaa cattggaaca catatagata atttaagtag gtagatgtat gtgctgttat     60
aaggaagtgg ggaggagaga agagggaacc gaaatcatat gcacaaaaat tttttttaga    120
atataaataa aaaatgtggt agtctaaaat gtcaattctt caaagataaa gttaggcttt    180
cagtaacgtt agaaatggtt ttctggaata tgtctccagt ctacctaact ttgaggaagt    240
aaatactgta aatagatgtt tcaaacgcat tttaaagcaa tgatcctagc atgtctttaa    300
gctacagtat tgtgctgtct ttgaaatgta aactttgatg tcttctcttt ctcttag       357


<210>  193

<211>  359
<212>  DNA
<213>  homo sapiens

<220>
<223>  CD14

<400>  193
gtagattctc tgggatataa ggtaggggga ttggggggtt ggatagtgca gagtatggta     60
ctggcctaag gcactgagga tcatcctttt cccacaccca ccagagaagg cttaggctcc    120
cgagtcaaca gggcattcac cgcctggggc gcctgagtca tcaggacact gccaggagac    180
acagaaccct agatgccctg cagaatcctt cctgttacgg tccccctccc tgaaacatcc    240
ttcattgcaa tatttccagg aaaggaaggg ggctggctcg gaggaagaga ggtggggagg    300
tgatcagggt tcacagagga gggaactgaa tgacatccca ggattacata aactgtcag     359


<210>  194

<211>  855
<212>  DNA
<213>  homo sapiens

<220>
<223>  FCGR3A (CD16)

<400>  194
gtaaggagcc ctggagcccc ggctcctagg ctgacagacc agcccagatc cagtggcccg     60
gaggggcctg agctaaatcc gcaggacctg ggtaacacga ggaaggtaaa gagttcctgt    120
cctcgcccct ccccaccccc accttttctg tgatcttttc agcctttcgc tggtgacttg    180
ttcttccagg gcccatttct ctaccctacc tgggtttctt ctaacctgga aatctaatga    240
tcaaatcaca ctaaaaagtc agtagctcct gtggattaca tatcccagga gcatatagat    300
tttgaatttt gaattttgaa agaaattctg cgtggagata atattgaggc agagacactg    360
ctagtggtct gaagatttga aaggaccact ttctgtgtgc aggcagggcc tcagctggag    420
atagatgggt ctgggcgagg caggagagtg acaagttctg aggtgaaatg aaggaagccc    480
tcagagaatg ctcctcccac cttgaatctc atccccaggg tctcactgtc ccattcttgg    540
tgctgggtgg atccaaatcc aggagatggg gcaagcatcc tgggatggct gagggcacac    600
tctggcagat tctgtgtgtg tcctcagatg ctcagccaca gacctttgag ggagtaaagg    660
gggcagaccc acccaccttg cctccaggct ctttccttcc tggtcctgtt ctatggtggg    720
gctcccttgc cagacttcag actgagaagt cagatgaagt ttcaagaaaa ggaaattggt    780
gggtgacaga gatgggtgga ggggctgggg aaaggctgtt tacttcctcc tgtctagtcg    840
gtttggtccc tttag                                                     855


<210>  195

<211>  2268
<212>  DNA
<213>  homo sapiens

<220>
<223>  TBXAS1

<400>  195
gtaggagtgg aatgaatgaa tgaaggagtg ggcgcgcgcc gtgctccgga ggagggcggg     60
tgagtggagg agcttcggaa agccacacga ggtcagaggc accgaagccc tgccgtgcac    120
gccgcggaaa tgcagccccc ggggtggtcg ctgggttcct gccggagtct ggcttccacg    180
ccaccctgat cttctcctcc tcgcgtctac actgtcccga gggccgccac tccatcactt    240
gaatgggagc tcacaactct ctgggtcctc gcttttctca gcgctctctc ctatcagggc    300
ttccgctaaa cactctccag actctcccca gccgggagcc tctccaggtt tgcttctcca    360
gctgcctccc ggatgcttgg ataggatgcc ctgccatccc ctccaactta ggaagacttg    420
ttgagtctcc tcttaggcac tgtttttaaa actgtgggtc gtgacacagt aatagatcat    480
aaaataaatg cagcggaagg caaccagctt tcaaaaagaa cgaaatggaa tccaatagaa    540
aatattagag tccattgccc ttagtaaggg caactattgt ttcataaacc ttttgtttcg    600
attataggta ctggacaagt gtactggacc atgatgtcaa ttttatttcc gtctgtgaat    660
cgtgggttta aaaaagttga aaagctatct gtgtaaaata atgatctcta acactgtata    720
actttcttaa aaacaacctc gtgattttct cactacttct tatcctttcc ggtctccatc    780
ctccgttccc atccttcagt ccttcccaaa aaaggcaagc tctttcacac ttttttagtg    840
gtacatcacg acaccttcct ctgtgtgatc ttgtactctg cggtcttcct tgcccccata    900
atcaatgcta cacttcctat cccttctctt aacctaatgc cattcacgtt tgcagaatcc    960
tagactactg ttgctaaaag gacctcagag gtcatctggg ccagccctgc ccttttagag   1020
ttgaagaaat ggagtccaga gaagtaaaat ctgttgccca atgtcacaca gtattgaagc   1080
ttaggaatag gtctcgtggc tcccactcta gtgttttttg ctccacaccg gtcatttatc   1140
tccttccctt ctatcctccc tgcaatcttt aactttagtc ttggcccagg tcatcctaaa   1200
tattgccatc ttcataatac gtggttctgg ccatgccacg ctcctggcta acatcctcta   1260
aggactcaac ctctgcaggt ggggctgagt gccttggctt ttcatcaagg caggcgagtc   1320
ctgacttagc tttctaagga catgagttca gcaagtcact gcttctctag ccaaactggt   1380
ttacttgtag cccagtgcca gcttcaccca tctctgtcac tgtgcctttg cccaagcggt   1440
cactttccca cccactttcc cagaggggta ccttctccat cttctctctt taagcagatt   1500
ctacctgtgc ctggctcacc tcctccacaa aacagcccga gatagcgtgg gagtaagtca   1560
gacctaggtt caaatcctag ctcttccact taactatgtg atcttggtca aaatgcttaa   1620
cctctctgag cctcagtgtc tgtattttga ttatgagaag gagaacaata gtaatgttct   1680
ccttttgcat ctgtaaatct ctatcatagc cttcaccaca caggtatgta actccctgtt   1740
aatacatacc ctacatgcat gtctctctgc ccctttctag tgctggccat tagaacttgc   1800
tgccataatg gcagtgtagc tacttatgtc tgtggagcac atgaaatgtg gctagtatga   1860
ctgaggaact gaatttttaa ttttaataac catgggtggt tagtggctac cattttggac   1920
aaggtgtctc tagactgtaa gctcagtaag gacagaaacc atgtttttct tgttttggat   1980
tgtatgtcca ataactgcat tgcctaacgc atggtgagta ctgcacacat atttgttgaa   2040
tggatgatag ctgcaatttg ttgcatgctc ccttgtgtcc agcacaacac tacaaactcg   2100
ataaaaggca tttcatatag tcctcatcac agcctctgag gctgggttag attagagaga   2160
gagttttata tagagggcag acacatagta ggggttcaat aaaagttatt attattctaa   2220
ctcctccctc tgaccagccc cactgacttt tgtctcatct ttccttag                2268


<210>  196

<211>  602
<212>  DNA
<213>  homo sapiens

<220>
<223>  DOK3

<400>  196
gtgagggggc cctggagggg ctggcctggg ggagatgcag gccagaacac acaggtccct     60
gagtgttggg ctgaggagcc tgggctgcac cccaggaagg ggagagacag gttggtcttg    120
ggttgtggag agtgctgcat ggaggcccag tggggcagtg gcccctgggg ggatgccaaa    180
ggctggtgat gttcagtggc tcgtgaggtg gagaggagca ggtgaacacg agagagattt    240
cagggagaaa gaaaagcagc aagatggggt gaggcgctca aaccaggacg ccgagtggga    300
aagccaggag ttggctagag aagggtcctg ggtggaggca gggccaggga gtgtcaggcc    360
cagggtgcgc agctgcccgg ggcgggacgg gggaggggcg ggaactcatg actcggggag    420
ccagactgcg atcagacgcg cgtgcccagc tgaaccaggt gcgtgagaag gctgccttca    480
ggtggccggg ggctccctcc aggtaggtgt gggcaccttg ggcagccaga accccaggga    540
ggaaatacat gctgccccca gcccctgagc tgaagacagg ctcccctccc cccggcctgc    600
ag                                                                   602


<210>  197

<211>  14420
<212>  DNA
<213>  homo sapiens

<220>
<223>  ABCA1

<400>  197
agtaagcttg ggtttttcag cagcgggggg ttctctcatt ttttctttgt ggttttgagt     60
tggggattgg aggagggagg gagggaagga agctgtgttg gttttcacac agggattgat    120
ggaatctggc tcttatggac acaggactgt gtggtccgga tatggcatgt ggcttatcat    180
agagggcaga tttgcagcca ggtagaaata gtagctttgg tttgtgctac tgcccaggca    240
tgagttctga tccctaggac ctggctccga atcgcccctg agcaccccac tttttccttt    300
tgctgcagcc ctgggagcca cctggctctc caaaagcccc taatgggccc ctgtatttct    360
ggaagctgtg ggtgaagtga gttagtggcc ccactcttag agatcaatac tgggtatctt    420
ggtgtcaatc tggattcttt ccttcaggcc tggaggaata taataactga gacttgtttt    480
atttctgcag agggttctaa gccattcact tcccagatgg gccaataatg ctttgagtaa    540
tctggagatc atctttaatg cgcaggtgaa tggaactctt ccacagaggg atgtgagggc    600
tgtagagcag agtgaactcc ctgaaactca gacgtcagct ctttgtctct ctatctctga    660
acacccttcc ttagagatcc catctctagg atgcatttct ctgtagttag tttctaagtc    720
tcttgttcct gttctgcctt tatttttttt tcctggattc taagccagta tccccacttg    780
gctgtcttaa tgtagcttaa catgtctgta atcaaaatga tcatctttct gagattcaaa    840
gggctataag ggactttgga gagaatttca ttcagttttc ctcaaactag aataatgctt    900
gcactgtctg taaaagaaca aaagtgtcaa agcatccttt tgttcactaa atttcctttt    960
ttattatagt gttacttaaa tattaggaag taaaagtagg tataaacttc ttataggctg   1020
ttattataca actatatgac ccatacatat ttacaaatta agtgcagcca aaattgcaaa   1080
atcaatacca ttcaaattaa taccttaaat gtggtgaggc agctgttgtt caactgaaac   1140
caaattataa gttgcatggc agtaaatgct atcatgctga tcattttgag tttggccagt   1200
ctatattatc atgtgctaat gattgaattc tccacccatt tttctacttg tatgacctta   1260
atttgatggc acctgttcca tcctcatgag tttgctacaa ttatactggt gccaacacaa   1320
tcataaacac aaatataaac ttgggctttg aaatcttgtg ccagaacttg gctttaaagt   1380
aagcatttaa aaaatccata tgtgtttatt agactttgtt tagatgactg ttgaaatgaa   1440
aacaaagtgt ttaaaatcct cttagagaac ttaaatataa tccctcagca atatgtatac   1500
agatcttcct ttgagaaaaa ctgattgtgt tcagcctctc atgttacaaa tggggaacct   1560
gaattctgag gtctctagtg agagaacagg gactggaatc tgtggatcct atctgtttta   1620
ataataattg taaagtataa tagataatat tatattaata aaataaaagc aaacacttag   1680
aatgagcttc catgtgtgag gcactaactg attaggcatt attaactaga tttattcctt   1740
ttaaggcccc gcgatgtact gttatttcca catgttgtag ctggggaacg tgctactcag   1800
agaggttaag taacttgtct gaggtccaca ccactaacaa ggagcacagg tagggttcaa   1860
atccagataa tctgactttg gagctggcac tctaactcaa tgtgcctaat cgcttttcag   1920
tggtgtcatt attttgccta ttctccatct gagaatattg aagtttctga ctccttcctt   1980
gcctttctcc ctgcctcccg tggttatccc caggtcttgg tgttccagtc ctctatgtcc   2040
gtccttactc ttattccttt gctacagtgt gatccagggc tcctgcccct tcttatcctg   2100
gtagaggggg cccacttgct gggaaattgt ctccgccatg gtttatccat gttgtgtgtc   2160
cattagtgag tagtgggaag aatcatatca tgttggcaat gaaagggggg ctatggctct   2220
ggggtagtct agtctgaacc tcttatttta cggatgagaa agctgaggta caaagcaggg   2280
aagggatttc ttgaggtcac ccagccagca actgagctgc aaccagaagc tgagatcccc   2340
aggactaggg ccgagcctca ttctgtccca tcacagtgac ttttcttccc tcctccaaac   2400
tatttttatt ttttattttt ttgcagctgc ttagcagctt gaagttagaa gaaagggcag   2460
ggaaaaggtt ttccgtgctt agccagggaa ggaatcctgc aacaggatgt ggggttgggt   2520
cattcaaatt gggccagact ccactggtct tgttgcttct tgcttggtat tgcagatggg   2580
tttaaaagtg ttaggattag agagataggc aggtttagcc aaaggcagtt tgtagccttg   2640
tggcagagtt ctttttaaag aaggaagtgg gatgcaacac cctgacacaa aggggcttaa   2700
gttgttatac cactgcctgc taacctgttt tccttaactc tcttcctgat ttctaaagga   2760
agtatatttt gctgaatcag aaagaaaagt gatttatttc aggttgctga tgcttagatt   2820
gttagagttg gaaagatctg gcttgcatct tgtacagctg acagaactgg ggctcagggg   2880
ggcacaggtg cccagagttg gtcagtcagg aaagtagcac cagaaccagt ctcctggtgg   2940
ccctacagtt gcagaccctt ttttgctttg ctctctgtgt atactaaagc ttctatgtct   3000
ctgaatctca agttctgact ggtagctact ttccaatcca cctggcttag atttctagat   3060
tatattgttt agacgtcaga acctcttaag ggttttgggg ccacttgtta gctcacatag   3120
tgagaaccag ccctgcccat taggtagggg aagaagttag cagtccatga tagctgttgc   3180
ctgcagcgta tggatgttca ttgcacagtt cctgtctcct gagatcctgg agtgtatacg   3240
cttggcctca gagcccagca cagagcctgg cccttgggac atgcttagta agtatttact   3300
gaatgagtgg gaaatgtctt aaggcccatt agtttgcagg tcttgaggag gctcccttgc   3360
actaggaaga atagaaagca tacataaagc ctgtgtgctg ccgccaggaa gactagaaac   3420
gctatgttca gcctggagct gaatggtata ccccagagca accctgttga aaggcagtgc   3480
ttgccttttc attctgtgtc ctggtttgct ggtaactcct gggtcccctg cctctcctgt   3540
acccccattg tgcagactga ggggggacca tcagccaggg ttagttttcc gctgtttctg   3600
ttaggcaaag aataaattga attgagttgt gaaagttggg tgcaaagctc agtttgggtc   3660
caaagtaaca gttaacttgt gtgggtggca ggtattcagt acaaacaggg ctggggacag   3720
gaaggggaag agaacttcag agctttcacg atcctcatct ggttttaggc tgatccagag   3780
gccaaggtcc ccatggaaca aactggacaa agtgagggtg gccacatggc ctcttttctt   3840
ttgcctttat tattaatttt ctcaaataga tctgactagt catgtggctg ggaaaatagt   3900
taattgtgat tttttttttt ttaaactgag tctcactcta ttgcccaggc tggagtgcag   3960
tggtatgatc tcagctcgcc gcaacctctg cctcccggga tcaagcaatt gtcatgcctc   4020
agcctcccgg gtagctggga ttatgggcac acagcaccac gcctggctaa tttttgtatt   4080
tttagtagag acatggtttt agcatgttgg ccaggctggt cttgaactcc tgacctcaag   4140
tgatccaccc acctcagcct tccaatctgc tgggattaca ggcatgagcc actgcaccca   4200
gccagagtac cactatttgg gcattcttta atgaaaaaga atgaactatc caaaaattaa   4260
aactcctcat ttatgagctt ttagagaatt ttacagagta gatggaaact ctctgcatcc   4320
tttccccact tctagtttca cctgacacat ttcttccctg tccttactcc tgggccggca   4380
gcagtggtca tgattccaat cccagcttgg ccaccatctg cctcagtggc ctaggaaaac   4440
tcctttctcc agagctttag ttttctcttc tacggaatga agaaagttaa aacaaataga   4500
catttattgt ttcatttgga taaatatcta ttaagcatct attacttgtg gtatggttag   4560
ctgggtatat agtggtgaag cagctgggca tgagtactgc tttcgtagag cttacagttc   4620
agtgaggcca gcagatgtga aacatatcat cacacaaata aaaatataac tatcaactgt   4680
gatgaggatt atgaaggaaa aaatccggca aactatggta ctggtgttag atactagcag   4740
gtgtgggtag ggatttcatt tagattgaca ggttgtcaca ttaaagctga gagccctgaa   4800
gttcaagcaa tggttagcca ggcaaagatc agaggcttag agatagggaa atccattcca   4860
ggcagagaga ctgggggtgc ctgtccccta ggtcagggaa cagaagaaag ccagtggcac   4920
tggtggagtg aataagactg gcgggggatg agttggtagt agacatgacc agatcattta   4980
gggccaattc tcctggggaa ggagaattta atttaatatt tatttattta tttatttatt   5040
tatttattta tttatttatt tatttttcaa gacggagtct agttctgtcg cccaggctgg   5100
agtgcagtgg agcaatctcg gctcactgca acttttgcct cctggtttca agcgattctc   5160
ctgcctcagc ctcctagtag ctgggattac agacgcccac caccatgccc agctaatttt   5220
tgtattttta tagagatgcg gtttcaccat attggccagg ctggtctgaa actcctgacc   5280
ttgtgatcct cctacctcgg cttcccaaag tgctgggatt acaggcgtga cccacagtgc   5340
cccctgagaa tttaatttta ttttatgtgc aagaggattc cctgaggtag tcaggccaca   5400
ttgtctggtg actcttggga tagagggaac ttgaatgaca aaggcccaag aaagcaattg   5460
taatcattac atatacatgg accattttat gctgttttct tctttcattt aacattattt   5520
agtgtgcgtg ttcacatatt tctaaatcat cttctgattt agaataatga tttctgatgt   5580
gtaggctgtg ttttatagtt ttgaaagtaa tactttgata tccattactt tcttgattct   5640
cacagcaatt ctgaggtgta tgcgttgcaa tttctgtttc acagatgaag agagtattgt   5700
taataagtta atggccgggc atggtggctc acacctataa ttccagcact ttgggagacc   5760
aaggtgggcg gatcacttga ggccaggaat ttgagaccag cctggtcaat gtggtgacac   5820
ccatctctac taaaaataca aaaattagcc aggcgtggta gcacttgcct gtaatcccag   5880
ctatttggga gggtgaggca ggagaatttg cttgaacctg gcaggtggaa gttgcagtga   5940
gccaagattg caccactgta ctcctgcctg ggtgacagag cgagactctg tctcaaaaaa   6000
taaaaagttg ctaagaggag ggctgggatc ttttggctcc aaatctactg tgggatgatg   6060
cctttgacat tcctgatagc tgtgcagtaa tccattaaca cagtttttat aagttcaaac   6120
cctgttgcca acatttagat tgttccatgt gtgctgttac aaataaatta ctataaagat   6180
tctatacatt taatctttta ttatttttgt attatttctg taggccaaaa tctgaggaac   6240
aggattacta ggttgaaggg aaatggccct tgaagtgtct gatcagatgt ctttccagag   6300
gatccaacca atttaaatag ccaccatcaa tgcatgagac tttgtagttc agggaaggca   6360
ggcctggttt taaaaatcat ttcccctctc tagcattttt ctgatgtgat ccttaagatt   6420
tcactttagt tttcccaggt ctcattggca tgtatgctgt tagggatggg tctaaaatta   6480
atttttcttc acattcatat catgtcatcc cagtgattat ttaataaata atcacttgat   6540
taaatagtga ttccttttct agttattttt gggacattta ttaaaacctg gatatggtgg   6600
ctcatgcctg tattcccagc actttgggag gctgaggtgg ggggattgct tgagactagg   6660
agttcaacac cagcctgggc agcatagcaa gactccatct ctataaaaat aaggaaatta   6720
gtcaggcatg gtggtacttg cctggagtcc cagctacttg gaaggctgag gtaggagaat   6780
tgcttgagtc caggtggtca aggctgcagt gagctatgac catactactg tactccagcc   6840
tgggcaacag agtgaaactc tgtctgaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   6900
aaagatgtgt agggagcaat tttggagtta ttcatttggt catttgatat gtagttttag   6960
ttttggtgct gatagagccc agaatgtacc ctgaatttga tgaacattct gatatatggg   7020
ggagctcatt gtcccccact tacctttttg cctctcagaa tatcttttga tatttttatc   7080
tgttttttcc ccattgaatg ttattacctt atcaagctca aaaaagtacc ctatcgctat   7140
tttaagttca gttgtgttaa atctataaat tagcttggga aatttggata ttaaatgaac   7200
tcatgaagaa gcagagttta gctctcctta attctcatct tcctttattt atcctactac   7260
agttctgtgg ttttctttta tgtaagaagc acatgtttgg ctaagttaat gcctaggttt   7320
ttttgtttat gtgtccattc tcactgtgga tagtattctc ttttccccac attatattaa   7380
tttaactggt tttcagagac taatagcaat gctattattt aggagaattt accttggttc   7440
tgattaactt acccatactt gcaaatcatt tgcagctttt tagttaactt tgtgagttct   7500
cttagattta cgaccatgcc agaaacagaa aggatatttt catctcttcc tttctgatgt   7560
ttattcttct tgtttccttt ttttatcccc cattatattc tcaagaatct ctcaatacta   7620
agaaatagcg acttcatttt tcagcgcgga gtgcattatt ttggctacca tgattcagaa   7680
gcctcttgcc taaggcccaa ttttattctg ctagttttct ctgttctttg tacatggccc   7740
ttgcgctgcc ctaaccttga attaacgtgg ctaaatctca agaatttaag agcaccgtga   7800
ctgtgtcctc aggctaggga gggaaatggg ttcacagagt gactggattg tggtctatga   7860
acttcggcag ccagcagcaa aagtcaggca tgaataatca agtggacagt gaacatctgt   7920
agtgtgggag atgttggcat aactatgaat gatgattcaa gagtggtttg atgcatattg   7980
aataacatga tgataagtac tagactctgt gctaagcctt ctatgtgaaa tacatttaat   8040
tctcataata actctagagc agtggttctc gaccggggcc ggttatcccc ctaccccacc   8100
ccaccctcac ccttccacca gggacataac atctggagat atttttggtt gtcacaatcc   8160
tgggaatgta tgtgctgata tttagaggtt gaggtcaggg atgctgctga acttcgtaga   8220
attcatagga gagtctctca caacacctat ctggccccaa atgtcagtag ggtcactatc   8280
aagaaaatct gctctagcag tgcctgctca tattatcccc atgttgaaat agcaagatgg   8340
gaagtgcaaa gtggtgcttc ggtactcttg gagcagcttt gactttggtg agaaacgcct   8400
tttaaaaaca atgtttcttc ccatcttccc accccatggg gaggtgtggg gttgggtggg   8460
taggcaccaa agcaagattt agaagagttt tctgtaggaa tttataatgg taaaggatca   8520
acttcatttc caagctattt atgagggttt atgtttagga aaagtgctaa gcttagagaa   8580
ggaggagaaa tctgatttta ttaatgagtg tagccataat ggcatatcct ggcagaagtc   8640
aactttggtt tctagaggga ggctattatg aaaagaaata cctggaacat tcccctgggt   8700
ttggaaggtg agttctaggt tcaatgatgg gaagaatttt agaggtccaa gataaaaggg   8760
caaagattaa attttgtctc tcatgagttc tctggctcag gtggtgtgaa ctttgcagac   8820
agtctcttta attcactcat acatgctagt ctcccagctc agcaagggct ttgagagagc   8880
aggtgtctgt atgctctggt aagtgaaggc aaagtgcata aggaggttgg ggtccataat   8940
ggcgaagaga aggagccctt cagtcagagt ggctttgaat cttggctctg ccatttgcca   9000
atcttggacc attgggcagt gtattaactc tttgaatctc agcttcctct tctgtaaaat   9060
gtgtataaca agagtactaa ttggattgtt tgatgattaa atgagttaat gtgtataaag   9120
cactcacaac cctggtacat agtaagacct ttcattatta ttatcatcat caattttttt   9180
taacctcttt tcctgatctg cttacactca ccagcttcag ctgctccaaa tggcttgtaa   9240
gattttttgt ttgccctttg ctgtcagttg ccatggggaa gatccattca tttttttcag   9300
tcaaccaaca tattttgagc atctgctgcc ctacaggatc ctagatatgg gggctgcaga   9360
gatatccagg aacataagcc ttgattaatt gggtcagatc agtgctcagc agggctggca   9420
agtgctaggt ttcttttaag tggcatatct taaaaggtat atgtcctaaa catagctttg   9480
tgatggcagc atgatgggta caaaagcaca cacttaagtg tcagtagatc tgggttcaaa   9540
cattggtgca gtttcttatg gctcgtaact tgttcaaacc tcagtttctt cacttctaaa   9600
acggtaatga tacaacctac ctcacagggt tattatgaat taaatactgg agatgagata   9660
cacaaaacgt cttgagtaca cagtagctgc ccaatattgg ctgtaagtat tataaatcta   9720
caagctgtga attaatttta cctctctgga tcctgttgat atttctagac cattccacct   9780
agtggggcca tttcctacct gagtcacccg tggtgtcaaa tagaatgtca tgtggcctcc   9840
tgagttgggt agaattggct gctcatctca accccgctac tgactatctc tgtgatttac   9900
ccttcctcca gccttagcct tgctacatat aaaatcaaga caataatgtt tcctatctca   9960
cagggttgtc ctgaggatta aattaagtaa ttaatataaa atgtgccttg tacatattgg  10020
gccctaaata aacagtagct actatttatc cttaaagtac aaatggtagt ttcagagctt  10080
caaggctgat ggctatttat cttactcata ctctttgttt agcttcattt ttttccccta  10140
atttcattag tattttcttt tctttttttt tttttttttt tttttttttt tttgaggtga  10200
agtctcactc tgttgcccag gctggagtgc aatggagcga tcttggctca ccccaacctc  10260
tgtctcctgg gttcaaacag ttctcctgcc tcagcctccc gagtagctgg gattacaggc  10320
tcccgccacc atgcccagct atttttttgt attttcagta gagatggggt ttcacccttt  10380
tgaccaggct ggtcttgaac tcctgacctc atgatcaacc cacctcagcc tcccaaagtg  10440
ctgggattac aggtgtgagc caccacgccc ggcctcataa gtattttcta aatttattta  10500
cagtcatgcc atttaaaagg aaagttgtat tcctgtcttt gttaatattt ataagtgatt  10560
ttattcagct acaagcttgg aatggcatat aattttgtat tctgcttttt tcacttaata  10620
ttacatggct aatgatttct gtgtttcata aacattattc tgatgatggc atgatatatt  10680
gttgagtaca tgtaccataa ttgaatcatt tccctattgc tatgcaatta agttgtttcc  10740
aatattttgc aattataatg tttcaatgaa tgaataactt tatgcatata gctttttgat  10800
atcttaagtt cagtttccta ggatgaattt ccaggaatag taattgggca aatgggataa  10860
acatgactct tgaatacgta ttgttaacat tgctttccca aagggctcaa ctgatttata  10920
tttccgtgtt cattatcttt taaaccagct catttactca ccaaacattt ttaaagccat  10980
tatcatgtgg taggcttagt aagaagaaag tgaccctaag ggagaagctt atatataaat  11040
agggtccctg gtgtaccaag tgctgataca gacacaaagt acctggggaa attgagatga  11100
gggagtcctg gctcagctgg gagaaaagtt cattttcata gagtcatggt tttgttcttt  11160
ggcagaaaga aaattgcttt cttccccacc cccaccccca gctttattga ggtataattg  11220
acaaataaaa attgtatatc tttaagatat gcaatgtgat atatatgtat atctcaactt  11280
aaaaaataag ctacagaata aaaaggtgtt tgctattaaa aaaaaagaaa aggctgaatg  11340
tcattcccaa gcttggaaat ttgagtatgt tgcctctttg ggattattta cagaaatatt  11400
agcaagacca gccccatctt tggtcttgag tactccactg tcagcatgct ttcttccaga  11460
gagggatcca tttgccttta tttttcattc tgttgtgccg tctatgcaaa ctattcttga  11520
tagttttatg gtaacagtgt ttttttgttc catgagataa tttatacatg ctcattgtgg  11580
aaaatttaga aaagacagga aagtattaaa aacatcactt tttttttttt tttttttttt  11640
ttttttttaa gagacagagt cttgctctgt cgcccaggcc ggagtgcagt ggcgtgatct  11700
cagctcacag caacctccgc ttcccaggtt taagtgattc tcctgcctca gcctcccaag  11760
tagctgggag tacaggcatg caccaccacg cccggctaat tttgtatttt tagtagagat  11820
ggggtttcac catgttggcc aggctggtct caaactcctg acctcaggtg atccgcctgc  11880
cttggcctcg caaagttctg ggattatagg caggagccac tgcgccagcc acacctacgt  11940
tcttatcatc ctagtacatc cactgtcatt atcttgctgt atttccttct gcccagtctc  12000
actctgatca tgcagtggcg tgatcatgca gtgatctcgg ctcactgcaa cctaggcctt  12060
ctgggttcga gtgattctcc tgccttagcc tcctgggttc aagtgattct cttgccttgg  12120
cctcccaagt agctgggatt acaggcatac acccccatgc ccatctaatt tttgtatttt  12180
tagtagacac agcgtttcac taaaattttg tatttttagt agagatgggg tttcaccatg  12240
ttggccaggc tggtctccaa ctcctgacct caggtgatcc gcctgccttg gcctcacaaa  12300
gtgattacag gcatgagcca ctgcatccat cgccaaaaag attttttaaa agagtttaat  12360
gtagaaccat atcaaaggtc tttggaaata aaaaacagtt ttttaaaaat atcagaaata  12420
aaacaacaaa taaataaata aataaaaaca cccaaaacaa tctgaagcac gagcacctag  12480
cagaaaggtt caattatgat ctattcatag agtggaatat caagtagaca ttacaggaca  12540
tgttttaaga ttatatttta tgtcatggga aatgctctcc cagtatgatg ttaaatgaaa  12600
aaacagaata caaaagtata tatgctgcat agtctcaata ttgtagagaa aaaatattat  12660
ttatgtatgc atgaaaaaag acaaaagatg ttaacagaga tccattgtta cttcagttta  12720
ctagggattg tctctgggag gtaggattaa ggtgatttat atttaccttt ttaaactttt  12780
ctgtattttt ttattttcaa attttccata aaaatataag gacttgaaga tcaagaaaaa  12840
atttctgctt tggctcagtg cagtggctca cgcctgtaat cccagcagtt tgggagccct  12900
aggggagagg atcacttgaa cccaagagtt tgacgttcca gtgagctatg atctccggat  12960
cgtaccgcct ggacgatgga gcaagaccct gtctcaaaaa aaaaaatctt tgcttttttt  13020
ttttgtttgt ttttgagacg gagtctctct ctgttgcccc agctggagta cagtggcaca  13080
atctcagctc accgcaacct ctgcctcctg ggttcaagcg attctcttgc ctcagcctcc  13140
caagtacctg ggattccatg cacccaccac tatgcccagc tacttttttg tattttcagt  13200
agagacaggg tttcaccatg ttggccaggc tggtctcgaa ttcctgacct cagctgatcc  13260
accggccttg gcctcccaaa gtgctgggat tacaggcatg agccactgtg cccagcccaa  13320
tcttttgctt tttttaaaaa aagaagacaa aaagggattt tataccagta ttatcttggc  13380
tgtgtgactc tgaagccaca gttgtaagtt ataattactc tgaaacacaa ggccctgtga  13440
ctcttttggg ctctttggtg tttatcttga ttacaacgtt ggaatataga aatgaaagga  13500
atgggagagg tgatagactt caggcagtgt aactagttgt ctgaacacta ctggctcaat  13560
tatattgtgt ctagtgattt ccatcttgtc cgtctgctaa tttatcgcct ggtaactcac  13620
tgaggcaggg ttttcctttg gagaaacctc attgttttaa ccagtgtatc atgcttgttt  13680
agaagttcaa tgatcttttt aactcatcgg agaagatgat gaccagacct ggacagatgg  13740
ggaaggactt tgcactctct ctttacagtc ctgagtgcac acaggtcaat atggaactat  13800
gtgtgaattt tcattgtctt tgagagccct cttctctgcc ccatagggag cagctttgtg  13860
tgcaattaga ggagcaaggg ttgtgtgtat ttagcacagc aggttggcct ggtcctctcc  13920
tctcaacata gtcaccacat acctggcact atgctaaggc tgggaatgca gacagatggg  13980
tgcctgcttt cagagtgctc aatgtgctga ggaagccagc aacagaaaca gatgatttca  14040
ggagctccag gaaaatgcta caggaggagt gtgcctgggt tactggagta gcacaggagg  14100
agggcttcta gctcaggctg agattttagt aaaggaaatt atgccacgat gaatcctgaa  14160
gaatgaatag aagtgaacca gataaagcac gataggaagc atcttccctt acctaaggga  14220
agacacagag gtatatggaa tggtatgtta aaaggttggg actccaaaca gttctgttaa  14280
agcttagaga gtggtgggag agactggaga agttgattaa ttagtaaatg aagttgtctg  14340
tggatttccc agatcccagt ggcattggat atccatatta tttttaaatt tacagtgttc  14400
tatcttattt cccactcagt                                              14420


<210>  198

<211>  1448
<212>  DNA
<213>  homo sapiens

<220>
<223>  TMEM195

<400>  198
gtgagacttt attggaagag gctactctta ttcttgctgc tttcttaata aatggtaagg     60
tcaatctcct tagggttttg ttcactttca ttattcaaat gattacattc taataataat    120
aattcagttt cttaaaggcg tgaagcaaaa gtagaatttc cacttgaatt ttcttacaat    180
ccatagccat cttcacctgt aaattccctc ttttatatgt cactccagaa tatgacaaaa    240
acaaaagttt aaagttttcc tggactccat ggcattgtaa atgtagctat tggaagctca    300
atgacaaata gttacaccac atcagtaaac tttgtaacaa tttcattttt aaatctttca    360
cttgtccacc ccttccaggg aaactatttc ctctttcatt tggtagagta gttcagcaga    420
atgaaggata tgcagcttga ccaggtccag ctctgacttc ctaagtttga atttgaccca    480
agttttcttt gaaactctga agtgctcaga ggcacatttc acttctggtt cctggctatg    540
attggaagtg gaaatatcca gaattagaac ttgaatactg aagttcccca ccctatcaaa    600
gttattccta caacactcac tagttcatgg cagaaataga aaaaaaatga catcatagaa    660
tatgttattg agagttcagt ttagaaagct tcaaaactca tgattagctt ccaaatgagt    720
aaaatccgta tctttttcaa gattagatat tacactttct ttctgagttt ttaagttaaa    780
aaaagtggca ctgatatctt cataaattat tattgtttat actgcaatat caaaccaaat    840
tcaatgctcc atcaccaata gtggagcttt caaaacatct cttattatgt gaaacaaaaa    900
tcaaaaccaa atgaataaaa tctgaatcat gttttaagca aacatgtaaa attaccatat    960
tctctaaaat tctaagcaga aaattgtctc tactctttga atttcatcat tagaaatagt   1020
tctggtaagt ctaatatgaa aaattagaat tatgtgcatc tttaaggaaa gcctcttgaa   1080
gtgggtctaa attatacatg tagagacaat agacctctaa ttatctacct tattctaaat   1140
gtatttttta aactaatttg gaagatgttc ctcttaatct tataatatta taattatcgt   1200
ggttatatct atgattacat ttcatattca aattggatga tagaatttga gcacatgttt   1260
agtgtatgtc taaaataatt agacttcttt accactgtgt aggaagtaat cctctaaaat   1320
gagtgtctac catctcctgc agggcttccc aaatctgggc ctttcaattc tgaaatgact   1380
aatcaggaaa tgtaaaataa tttcatatgg aacataatag catctctttt ctgcaacttc   1440
ctttccag                                                            1448


<210>  199

<211>  3633
<212>  DNA
<213>  homo sapiens

<220>
<223>  TLR4

<400>  199
gtatgtggct ggagtcagct cctctgaact ttccctcact tctgcccaga acttctcact     60
gtgtgccctg gtttgtttat ttttgcaaaa aaaaaaaaga gttaaattac cttaaagact    120
caagaagcca cagagatcaa ataattcatt gttacagggc actagaggca gccattgggg    180
gtttgttcca tttggaaatt ttgagtgcta acaggggcat gagataacat agatctgctt    240
aaggtccctg ctctgctacc ttgtggctct gtgaagaaat tatcaaacct gtctgagact    300
agttttcgca tctgtaagag aattataata ccttcttcac tagagagtaa gcagactgct    360
tcagtgtcat ttcttcccac tggtggtctt tacactcagc ttcaagcagt caccctgctc    420
ctttcaatct caggaaaaag atggcttttg tgtgtgtgtc tctagagaaa gaactttcta    480
agtgggtgtc agacttctgt atgcagtaat atagtttagt ccagaggatg aaaaaaataa    540
gagaatgaaa aaggaaaaga gagagagaga gaagaaaaaa gcaagaggga aatatgtata    600
atgtcagcta atgcaacagt ttctttctta gtgaaatacc aatcagctgg ttggtaatct    660
tattcatgat ggatctcttt tgtttttccc ctgcgcagac ttcacagttg ctttagaaac    720
ccatagtaga gccgaacagc taagaaaatg atttacagtg aggcagggtc agaaactcaa    780
gagagaaaaa gccagctgca gtcctgaagt tgaggatata ggagaaaatc aagtaatatt    840
tagcaaagac taattcatta tcttgaagcc atcccttccc tcaattccct gcccatagtc    900
ctcctccttg tcctcttctc tgtatccctc tgctgttagg ttaatggaga tagattttct    960
aattaggctc actgcgagat aaaaccacag ccaaacttga cttcttttcc ccatgtacct   1020
tttcctgtca gtccctgaag cctgtccatc cctgcccatc cccttagttc cactgtaagg   1080
caggccctca tttcccctgg cattgactct tacacactaa ctgctttcct gattccagtc   1140
ttcttccttt aattcattct gcacgttctt gtttgttatg tacttgcatt tgttgttatt   1200
atttttcctt aggcttcaat ctaacaaatt actctcctta aaaactttta ataactctcc   1260
attgccatta gaacagcttt ctaccacagg gcctttgcac tggctatttc ttctacctag   1320
aatgctagat cagtgctatc cattggcaat attatgtgag ccacatatgt acttttaaag   1380
tttttagtag cctcattaaa aaaagaaaca agtgaattta atttcgataa tagttttatt   1440
taacttagcg tatttaaaat aatgtttaaa attttaatat atatttacct attattgata   1500
tttttacatt ccttgtttgg tactaagtct ggaatttagt atatgtttta catttaccac   1560
acttctcaat ttacactatt cacatttctt gtgtttgata actgtgtatg gctagtgact   1620
accgtattgg tcagtgcagc ccaagtcctt ttcatgcttt aatcactcca ttcagatctc   1680
tgattaaatg tcccctcctc agggcagtct tccttgattg ccccatgtag agctctccag   1740
cctcacttat ttgcctcaaa tccccttata ctgcttaata tttttttttc tagagcacaa   1800
cattttatat ttttgtttgt ttattttctc tctctccctt tgtaatggaa tcggtaagga   1860
ggcaggatca ttgctggttt tatttaccac tatatttcca gtggccagca cacagtagcc   1920
gctagatgtg taagtgataa atgattgaaa taattgctgc aggacaaagt ctgaggccct   1980
cctgatctgg cttgccctct tacttagatt tcaccactcc caccactcac cagctaatct   2040
gagtttgttt tccactcttt acgtgctcac gttgtcctct ccttaggaca tgtttttctt   2100
cccctttcca catatctaaa ccttactcat cttccaagac ccactttaaa atcttccttt   2160
tctgggaagc ctttcctgaa tccagacttg atctctgctt tctctgaacc acagggcata   2220
ttttctaagc ctattttatg gccccttgag atagtgttag ctttgctcct atctaaactc   2280
ttactctaga ctgtgagtcc attgaagtct ggagctgcat catatttttc tttgtaatgc   2340
ccacagcact tggcaggaaa tgcctacaat ttggacttaa gtaaaccttc atttaatcag   2400
ttattcaatc agttagtgat tcagcaaata tttattgagc accaaccatt tgccagacac   2460
cattctgagt gctggagaca aagcagtggg caaacccatc aaacttgcaa tggaatacag   2520
gagatgaaca atacgatgag aacaatcaga tagacaacat aatgttagat ggttgtgctt   2580
cccgtgaaag ggaataaaag agggcaaaga aagagtgcct ggcactgttt ctattagaca   2640
atattgtctt tgaggctcca tggcttgcaa catttaagca gacatacgaa tgaagatctg   2700
catgtttgaa ctctgacttt gcgcatatta cttcatttct ttgaatttcc attttcctca   2760
tctttaaatg cttatttgaa gattaagtga aagtatataa caaacaagaa ctatgcaggc   2820
atatggtaag ggattaatga tagatgataa taattaatgt tgacatctat tgatcactta   2880
tactgtagcg ggcttttaaa taaactcttt aaacacctta tctcatttaa tccttcaaac   2940
attctattgg tttcaaacaa cagaaaacta caattagctg gcttctgcaa ggaattttgt   3000
tggaggaaat gagagcattc agaaattaga tgggagcgtt agagaattag gcttacaaag   3060
aatgtgggaa agtaggctag aaagcagtgt aaaaacaaag acagcataaa gcacttgacc   3120
ttatttacta ggttccacca tgggaatcca tgcactctaa agatttcccc ctatttctac   3180
atcactttgc tcaagggtca atgagccaag aaaaagaatg cagttgtcaa aatctgggcc   3240
atgactaagg aaggtctgga catcttgact gccagacagt ctccccaatg atatggagta   3300
tttaaaatga tactggatat tttatttatt ttttgtattt tcaactttta agttcagagg   3360
cacatgtgca gagcatgcag gtttattaca taagtaaatg tgtgccatgg tgatttgctg   3420
catagatcat gaaaatatgg aacgcatcat ggatttgtgt gtcatccttg tgcaggggcc   3480
atgctcatct tctctgtatc cttccaattt tagtgtatgt gctactgcag caagcacgat   3540
attggatatt ttattaccta cattttacat atgataaaat gaggctcact gaggtttttc   3600
ttttgttcgt tttattttgt tttgttttta aag                                3633


<210>  200

<211>  422
<212>  DNA
<213>  homo sapiens

<220>
<223>  MR1

<400>  200
gtaagtgttt tgagcttatt gtgctgggtg ctagagtagc agggaggaca gacctaagtt     60
gaagattacg ggacaatcta agtgacacct gctatctcag acagagactt cagcatcata    120
gggagccaga gcagggagtt ccaagccgtg ggaactgtga ctctttctta ctgaccctta    180
agcaaaattc taagctccag ggaagcagag gcagcagctt gagctccctg attgaccaga    240
tatgattaat ctttgtttct ctgtgctttg aacatgacta tgctccataa atatttaaaa    300
attgggaata gggtgaagat agatacacca aaaggagcaa gcagtgtctg aaaccagcaa    360
agacttaaaa gttaccgaag aaggtgttca tgctttcatt ttatcttttt tttttaacct    420
ag                                                                   422


<210>  201

<211>  393
<212>  DNA
<213>  homo sapiens

<220>
<223>  FCGR1A (CD64)

<400>  201
gtaagttgga ctcagagggg acagttagaa gggtacaggc tgtggctgtt gtgagtcaag     60
agttttgtct tcctgtggta actctgggta gaactcatga gtatgaagca acttgtatct    120
gtgcttccat ggtttattag agcttatttt atgaaaagga tgggaagggc aaccctgagg    180
tagcattaag cctggacgca ccgcagtgaa gtttccttga taaccacctg tagcttgttc    240
agttctgtta gtactggatt ttgagaaaga gaaatagaaa ctcaagagat ctgagttgat    300
ccctcagagt ctacattaat tctgtctccc caattctctc ttcctcatta ttttccttgg    360
accaactgat atctttattc tctgatctct tgc                                 393


<210>  202

<211>  1273
<212>  DNA
<213>  homo sapiens

<220>
<223>  CSF3R

<400>  202
gtgagtaggg gatccctaga gaggggctga gccttgggct tgatggagag ctggaatcct     60
ggggccactc cccacagctc tgccaagtgt tcatgtccgg ggtcctaggc ctggggcccg    120
ggattcgtcc tttggaaccc cagccctgga cactgagtct cttttcacag gatgccccta    180
cttttggggg tattgcacca gggaagtcac tcacagccaa gtatctcctt ggggacactg    240
agctgggctg gggacaggca taatcattct cccctcccca tgcctctgtc tctcaggacg    300
tgtgtgtctg tgagttccag ccgcgcaacc cctccccgtc tgggtctcta tttcactctc    360
tgtttccatc tttcctcctc agcttctctc tggcttgcta tctctctgag tttctctgtc    420
tcgcatattt cctgctatct cttgaatctt aaactctcgg taacagacgc ttcccgggct    480
ccaggcctcc gagtgccccc cccccgccca ctctctgggt cggcgtacat tgggcccttt    540
ttctctgtct ctcgatatct ctctggcctc aatcgtcctc ttggcgagtc tctctgtcgt    600
ttcagtctgt gtggatttca gtcaccgcct cactctgtca ctcttcctgt tgctctctct    660
ttttctttat ctgcagcata tctggaaatg cctctcccct ctgtttattc ccagccccct    720
cctccctccc cacccttccc acagaaagaa tctcgaggtg agagtagaaa cagcaaggga    780
gcgaggggtg tgaagtgggg aagagagtgt gaggggagag ggctgagcgt gatgagggag    840
aaacagaaag agggaatgtg aaggcagcca gcccaggaga catcgagctg tgctgggcca    900
caggagtgag cacctgcaga gcccagcaga gatggccgca gtgacaggag ggccaggggg    960
cccaggagtt aggaggagag gatccagaaa gggggctttg gaactgcgca gtgtggcaca   1020
gacaaaagca aggtggcagt cctgggaggt gtgaccacac aggctgtgag ggaggcaggg   1080
gtgaggggaa aactgaactg tgctggattc tgtgagctgc tgacctgcta tttatggctc   1140
gtgaaaataa cctatggttg ctgagtgcca actccatgca aggcacaggg ctaaatgcct   1200
ttaccaaaat aatctcattt catcctcaca acaacgctga ggagtgagtg ctaatgttat   1260
ttctttccca cag                                                      1273


<210>  203

<211>  29639
<212>  DNA
<213>  homo sapiens

<220>
<223>  FGD4

<400>  203
gtaagtggtt tcattttcta gtagatatat ttttttcttc cccagcgtgg gtcactttat     60
aacactgcat gccgagggat gtaaaagtgg cagagtttgg ttttctttta aagttaataa    120
agctcacatt ggttttcaag ttcaagatta aaatatgtgc tattgatggg ttttggctct    180
ccaggaggct tcttctgggc taaccagata caaatgagtt tgatagttaa gtttctctgg    240
cttattttta ttatcataag taaagtttgg aaatttggtc attgagggga gaaatataga    300
gaaagaaagg aacagttttc tctttttcct cccatttctg gtgtgaacaa atgttaagaa    360
atatttacca ctaatcattt ttctagtgct actgcacgga gcattgttct gttaaaacaa    420
acaaaaattc ccaccatccc agtcttgttt tggtgaagtt caggggagta agtattattt    480
gtttttctgt aaaagacaac attgtagaga taggcatgag tttgtttttt aaaaattgtt    540
agtggtagta gtattaagcc actgtggtct ctttgagtgt tgtagagagc atattaatga    600
gaaattgagt ctttgaaata gaaatgtaat tcaactgtgt gatagaaatg taatcatgtg    660
acgggaaatg tctgctaaaa atatttttaa tcactgaaat gggttcattt tgtttatttt    720
cccattcgtt tttgactgga tataagcctc actgaaaaat gtccacactg ctgaacaaga    780
taaactacaa cttagaaccg gcagccttca cagttaccag tattctttct gatggtggtg    840
tggctctttc cttccttaag tgtcaggggc atacgctgag tgtggaagcc caaggttggg    900
gttggtgaca gcactgcctc aggagagctg aggcgccact cctgcagctg cacagctggc    960
tccgttccca ggttctagta gctgcgggag ggttaagcag cccagtccat gcctgcccct   1020
gctccctcca tcactcaggc agaagcctga attcttttgc aggcgttcca ccactcttgc   1080
ataaagtttg gaggtcttgt gatctctcca aaatttacca tcatactcta aatatgaaat   1140
taaaaaaaaa aaaagaaatg cagcaaaagg gaagtgtttt ctcaccccaa gcagtgaagt   1200
tttaggttct ctttttcctg aaatagcttc tgtccattct catttatctt caaacagtta   1260
gagatgattg gagagacagt attccctcct ggaaggcagc tcttaattag agaggaaaat   1320
atttctagaa caggaagatg aagcttgaga ggtgaatgtt gataaacata gagaacttgt   1380
tggctcttgt tttctgcttt aatggacagc accctttaga gagtggccac tacaacaata   1440
tggactttat aagttccttt ttaggttttt aaactgagaa gacagtaata tagcacttcc   1500
tgcctacact actggataat tttgttaaat catctaagaa aaattgtaaa tatgcatatt   1560
tagtgcacat gttattttat aacagttttt tttttttaat gacctgaaaa aacttctctt   1620
tctaaagctt acgctttcag gcaaactcct ttcacatgaa agaaatgaaa tatgatagag   1680
tatgatgaat gactcaatag gaaatattat gcagttcttt ggaagaatga taacttggtg   1740
ttcctttaat aaacatccaa atgtacatgt aacctaaact gcaaactagg attaagattt   1800
aaatttaatc agttcttctt agatactaga atagacttga ggaggtcaag agtagatagg   1860
agactcctgg aataatccag ggaaaagttg aagtcattta tttcaaaaat aaaaaggtat   1920
tttcttagat gttttgtgga ccatccctgc ccacttcctg agccaccttc tgataacctt   1980
tactgtaggc acctgttttc tttataaaat aacaagctaa tttttattgg ctaaagtaca   2040
tttgtaaatg tcttcaccct ggtttgtgtg tgttctctga tttatctccc accacagcac   2100
ctgctaagct ctggctagaa cagatccttc catttttatt ccctggcgaa ttgacacaag   2160
ttagttggtt atacgttgaa gcaggcagaa ggaaaacact taggagaaga aaaatagtgt   2220
taatcgtaga atttggtcat tctacatggt ggttattata ataaaacttg gcctggggaa   2280
aatgagtctt tcaccctctt agagaataag tacacacaaa tacattttta aaacatttaa   2340
acaaacaaac aaaaaagact gtgtcactgt ggtcttgtct tttccatgcc attataaagc   2400
agttatttct tttttttctc tctctctttt cttttttttt tttgagacag agtctcgctc   2460
tgtcacccag gctggagtgc agtggcgcta agctccacct ccggggttca caccattctc   2520
ctgcctcagc ctcccgagta gctgggacta caggcacccg ccaccatgcc cggctaattt   2580
tttgcatttt tagtagagac agggtttcac cgtgttagcc aggatggtct caatctcctg   2640
atctcattat ccgcccacct cggcctccca aagtgctggg attacaggcg tgagccacca   2700
cgcctggcca taaagcagtt attatttctt atgcttagtc ccaaaaacct agtcttcctt   2760
gagtcatttt tctcttatgt acaatctggc aacaaatctt gcttcaagat atatcaaact   2820
gactatgtct tattgcctct actgttactt gccctgcttt aggttacaca cagctttccc   2880
ctggattgct tctactagcc tcctatctac ccttgacctc ctggagtcca ttgtctacct   2940
aacagcctgt gtgcacctct aaaaacggag ggcagataat tgccacttct ctgctcgcag   3000
tccttcagtg aattcccatc tctttcaaag gaaatcccct gttctttcaa tgatgtgcaa   3060
ggccctacct tctctagccc ctatccctat ccctacccct taactttctg acctcagcat   3120
caaatatgct ccctagtcta tccatgttgt cttccttatt tctctttgaa catatcaact   3180
gtgcttctac cttaggattt ttgtagtttt acactttgct tggaatgcta atcctcaaaa   3240
tatgttatgc cttattccct tcatgtctac tcagctagca gagtattagt gagacctcct   3300
tgtcctccct gtatatagga tataataata gcctctcacc taatagcacg cctgttcctt   3360
cacccagctt tactttcgtt atagcagttt ttttgtttgt ttgttttgtt ttgttttgag   3420
acagagtctt tctgtcatcc aggctggagt gcagtggcgc agtcttggct cactgcaacc   3480
tctgcctctc aggctgaaac gatcctccca cctcagcctc cacagtagcc aggacttaca   3540
ggcacacacc accatgcctg gctacttttt atatttttag tagagacatg ggttttgtca   3600
tgttgcccag gcaggtctcg aactcctgag ctcaagcaat tcacctgcct tggtttccca   3660
aaatgctggg attacaggtg tgagccactg tgcctggccc atcatagcac ttttaccatt   3720
tagcatgtta tacaggttat ttttttgttg tggtgttcac tgctatgttc ctagggtcta   3780
gaaaggtaac taatagatac tgggtgcttt gttaatattt gttgattgaa tacatttcta   3840
atattcagtg cctttttctg ttgggaaatg taaaatgagc aggaatataa gaagtttaat   3900
aaattataaa tatttgtagt gttctccatt tcttcccttc agttctcttt taagaataaa   3960
tatccttgct tgctaacctc tggtgtccct tgttgagcag catgtcaata atgagttcct   4020
gctattggaa gcctcacagg ccaagttgat ataaagaagt atgaagaaag tatggagggg   4080
ttagtgggtt agtgagattg gaatctgtgg ctgagcccgt acatgatttt ggatgattaa   4140
ttaatgggct gtgtcgtaag acagaaaaga gatgagggag aagctttggg gtgtgaaacc   4200
aagaaatctg gagcgatact gtctgtgtgg agaaaattgt ggccaagatt ttttgctatt   4260
aaagatgtac ttaggccagg cgcagtggct cacacctgta atcccagcac tttgggaggc   4320
caaggaggga agatcatgag gtcagaagat ccgagaccat cctggctaac accgtgaaac   4380
tccgtctcta gtaaagatac aaaaaatcag ctgggcgtgg tggcacgcac ctgtagtccc   4440
atctactcag taggttgagg caggagaatt gcttgaaccc aggaggtgga ggttgcagtg   4500
agctgagatc gtgctattgc acttcagcct aggtgacaga gggagactct gtctcaataa   4560
ataaaaagat aaaaataaat aagaaaaaga ggtccttaat attttatatt aatgatatac   4620
ttgccccact ttttgttttt tctcttccta catttaagtc atttcactct ttgaagcact   4680
cttgtaggag ggtgatagga aaagtaaaac gattgaataa aaaataatct agaaatattt   4740
ccttagtagt tcctgtaagg cttgatgtgg aatagaaaac caatacacgg gccaggtgcg   4800
gtggctcaca tccgtaatcc cagcacattg ggaggctgag gtgggtggat catctgaggt   4860
tgggagttca agaccagcct gaccaacatg gagaaaccgc atctctacta aaaatatcaa   4920
attagctggg cgtagtggca catgcctata atcccagcta cttgggaggc tgaggcagga   4980
caatcgcttg aacctgagag gcggaggttg cagtgagctg agatcgcgcc attgcactcc   5040
agcctgggca acaagagcga aactctgtct caggggggaa aaaaaaaaaa gccagtacat   5100
gaattaaagt gtaagaatta tttgtgttta cacttcatgt aatttatttc caaatttatc   5160
tagataattg gaaattgacc tgcattttaa aatctgtagc caacagttaa tgttaaaaaa   5220
aaaagttccc ttccccaaat gcagttaaaa tctatgaact gctgtttgct atttgataat   5280
atacttgatc tgaatagtaa ttatacatta ttagattaca tgacttctta gaaatatgga   5340
atcaattttg actatagcaa aaagaaatta tacaaagctt gaaaataatt ttgttatttt   5400
ataaatgtgt aagcccctta atgtctatca gtagttactg atttattaga aatatcatgt   5460
ttttctctaa tattgcccag taaatttttt ttaaatttat ttccatcaga gttactaatt   5520
tagagtgtaa aatagcaaaa taagaaatat caaggaaaaa aggtatttct ggtaactttt   5580
tatctaaaat tgaccatttt gatacagaat ggtaacaagt catgcttagg gttaggaaat   5640
gtaactgtat tcactatact caatcctaaa aattgtgtaa tacctctatg ttcaaggagg   5700
tttaagttcg cctccctcat agacctctaa atgcagtgac tatgagaaat gtcataggag   5760
aggtacaaaa tatgtttgga gaatagaaaa ggaggaacaa ctgtttcatt gattcaagga   5820
aatttcctca aaaaaggtaa cattggagct agatattgat aaatttgttt aaacaaagac   5880
tttctgtttt ttaagctaaa agaaccaacg tatgcaaaag cagagagaaa catatgaaaa   5940
gagaactgtg ttttccagga atggagaaga tgagaatgtg gctagagtgt taggggtgca   6000
tagttctgag tagatggata ttaggccctt caggagattg acgccttttt ttttctttct   6060
ttcttttctt tttttttttt ttgtgagaca gagtttcact cttgtcgctc aagctggagt   6120
gtgatggtgt gatctcagct caccgcaacc tccacctccc aggttcaagc aattctcctg   6180
cctcagcctc ccgagtagct gggattacag gcatgtgcca ccacccccag ctaattttgt   6240
atttttagta gagatgggat ttctccatgt cggtcaggct ggtctcgaac tcctgacttc   6300
aggtgattcg cccgcctctg cctcccaaag cgctgggatt acaggcaaga ttgatgtctt   6360
aatgtgaagg gtcctttatg caagctagag gttttgaggt tccccctccc catcgagcct   6420
tgcagttcca ttaaaggatt ttaagcaagg gagtaataaa attcgttata tcattgaatg   6480
aataaaatag tcagactttt tatttgtagg agaaaaattg tattagatgt agccaaatat   6540
ggcttaagta atgcagtttt aaaattcaga attggaaaat tggtttatct ttgattaact   6600
ggttcatttt ttttcttcct aacttctttc ttctgtcagc caaaaaaaaa taggaaataa   6660
tggataagct agaagcagta tttgcttttt aagttttgca tgactgaaac aatcccctac   6720
actgttagaa gcctaacaca caatgctatt gtgctctggg tctagaaaaa atgtgaggcc   6780
tgctagtctg attttgcagc agggagtaag gaaagccaat acttaacttt gtaagctgct   6840
aaatattaaa tgtttagtaa aatggggttt atagtaatgt tttttttgag acagagtctc   6900
actctgttgc caggctggag tacagtggct cagtctcggc tcactgcaac ctctgcctcc   6960
gggttcaagc ggttctcctt cctcagcctc ctgagtagct gggattagag gcgcctgcca   7020
ccacacccag ctaatttttg tatttttagt agagacgggg tttcaccacg ttggccaggc   7080
tggtgtcaat ctcctgacct ggtgatccgc ccgcctcagc ctcccaaagt gctgggaata   7140
caggcgttag ccaccgtgcc cggccagtaa tattttttct taaaaagaga atatcaaaat   7200
aaagaggaga gtcaggagta gagggtatca ccaagccttt tttagagtca cctaatttgt   7260
tacatgtttt tcttaaaatt accaaccatc aaaaagaaga attttgatct atatctatgc   7320
ctaagagatg tcagtagagc agtaaaaata tttctctaat ttataaggaa gttaagtaac   7380
tttcccacag tcaaaataat catgtcaaaa atttgacctt tcaaccacta gttttagtaa   7440
tccaccctgc ttttttcctc agggaaaaaa aaaaatgtac ttcccagata aacatcacct   7500
tgcgtttcac cgcaggtctg ggtgatcctt accttggaac aaatgatagt gttggtgcat   7560
ttaaagtagc agcttttggg tgactggctg gtcctgagga gtttttccta cttagcagtg   7620
ttcattttat ctattaatgc cgtgaagcaa aatacaggtt gaatgagcag tgttggtaac   7680
tgcaaaacaa agtgttgcaa cacagtaggc tgaggtagtt ttaagcagat aaagtctaca   7740
gaaattagtt tacagaaata gtgttaggct gggatgtttt agctgctaga tttcagattt   7800
agagaaatca agtttagaaa aataaaccag caaagtagta caaaattaat agcaacaatg   7860
tcaggaagaa tttgcttatg aaaaggatct attttccctt ttgtgaagag aaacatttgt   7920
tcacccttgg ttacttgtga ttgagataat taaaaacaat tttatttggt tttagcagcc   7980
tccttgtgaa aacttatgaa atattaggca gtttgatttt cttctcctct ctggacctgc   8040
agataaattt gttgtgaata aatggaaaat agtttggcag tgggcagaag caagggaaaa   8100
gccaagaatc tggtcgattt ataaaccaga cattgtgaat aaatgagttg gctacagctc   8160
ttagaaaaag gcttttgcct ttcgagttct tttcctacat ctgcttttat ttctttcaca   8220
ctttatgaag tcaataaaaa ttttgatttc attgttacag aagtttctcc ttgtatagga   8280
gcttttcatg ccctctgttg gccataaata atttactttt gatttctcaa ggctcctaac   8340
tggtgacttt tcatataagg ggatgtctag gttgtttttg gtagtgatat tatctctttg   8400
tacccagaga acacttctga caccaaatgg ggggttttct tcacagcaac aaccagttct   8460
tcagctctac ctggagttag cgtcagatcc cataggtgaa acgctgagtc ccacaagact   8520
atccccactt tagatgccag tcacaagtcc caggcatccc gtagttctga ctgactcacc   8580
gtaaatcaga ggttcccatg aactcctcat cagatttaat aatttgctag attgggtcac   8640
agaactcagg aaagcacttt actgacattt gcttgtttat tataaaggat actatgaaga   8700
atatagatga acagccagat aaagagagat taatacataa ggtgaggtcc agaagattcc   8760
tgaacatggg tgctcctgtc ccatggggtt agggtaggcc accctccctg cacatggatg   8820
tattcaccaa cttggaagct ctctgatcct tgtcacttag aggtttcatc atgtagacgt   8880
gatcaattat taactcagtc tccaggcact ctccctctcc agaagttggg aggaataggt   8940
ctgaaagttc catgcttctg atcattactt ggtctttctg gcagccacct ccatcctgag   9000
gctacctagg gttacgccaa gagtcatttc atcaaaagag gcttctacca cccaggaagt   9060
gtcaagagat ttaagaactc tccgttagga acaaaagatg ctcctattat ccccaccact   9120
taggaaatta caagagtttt gtttttgaga cagggtctca ctgtgttgcc caggctggag   9180
tgcagtggtg caatctcagc tcactgcaag ctccgcctcc tgggttcatg ccattctcct   9240
gcctcagcct cccaagtagc tgggactaca gatgcccgcc accacgccca gctaattttt   9300
ttgtattttt agtagagacg gggtttcacc atcttagcca ggatggtctt gatctcctga   9360
cctcatgatc cgcccgcctc ggcctcccaa agtgctggga ttacaggtgt gagccaccgc   9420
acccagccgg aaattacaag agatttaagt gctgtccttt gtcagaaacc agagatcaag   9480
tatatatatt tttattatgt cacaaatgga ttctaaaatc agataatctt actattactt   9540
atctgtgaag aggacttcat actttgcaca gaagtatttg ctgtgactta aacaagagtc   9600
acatggtgct atgagcttaa ataattacta gtaaaatttg gccagagcca gcagccatgg   9660
cttatgtctg taatcccagc actttgggag tccgagatgg gtggatctcc tgaggtcagg   9720
atttcgagac cagcctggcc aacatggtga aacaaaaaat gtctctacaa aaaatgcaaa   9780
aatgagctgg gcgtggtggt gggtacctgt aatcccagct acttgggagc ctgaggcagg   9840
agaatcactt gaacctggga gggagaggtt gcagtgagcc gagatggtgc cactgcactc   9900
cagcctgggt gacaaagcaa gactctctca aaacaaagaa aattgttttt ggctgggtgc   9960
agtggctcat gcctgtaatc ccagcactct gggaggctga ggcaggtgga tcactttgaa  10020
ctcagtcgtt tgagaccagc ctggtcagta tggtgaaatc ccgtctctac aaaaaaatac  10080
aaaaatgagc cgggcgtggt ggctcacacc tgtggttcca gctactcagg aggctgaggc  10140
tagaggactg cttgagccag gaagtggagg ttgcagtgag ttgagatcgc accattgcac  10200
tccagcctgg tgacagaagg atactctgtc tccaaaaaaa aaaaattact attaaaatta  10260
gtcttcatgg tgttttggtg aactttagct taccagctga aaattatgga attcatttca  10320
tatagcttcc actataaata ctattttgat ccaagcctgt taataacact aagcatggtg  10380
actctcaacc atgactgcac agtgggattg cctgggaagc tttaacatac actgatacct  10440
gggtctcata tcccagagat tgacttaagt ggtttggggt gcaacccagg tattgcagtt  10500
ttctttctta aagttccaca ggtgattcta atgtagtcat ggttgagagc tactgacctt  10560
gagaagcatg attttttaga ggtggctaac ccgttctggt ctactggttt acatgcagta  10620
gagatagttg gggaagataa tttttgctta aaataggaaa gcaactgaca caatcgcatg  10680
gtaggcatgc agggtttaga acagtaagaa actgaagatt ataccatata acactgtgaa  10740
tttattaaat acattccaga gtgggttatc agccaagatg tgctagatca actgtgtatg  10800
gtgctgctaa tgagttcaca gaaacctaga ggtttttact tgcccaaggt cacaccacta  10860
gctggggaca caaccaaaac tggaaaatta tagtggtaat tcatagtttg ttgccttgat  10920
tatttaggtc aagttctgta aactttttct gtgaagggcc agattgtaaa cattttaggc  10980
tttgcaggcc atatggtccc tgttgcaact actcaactct actaacatag taaaaagcat  11040
catacacatt atgtaaatga atgaatgtgt attctagtaa aactttattg acagaagctg  11100
gatttggcct gtgacctgta ggctgcagat ccctgattga ggattgtttt aatcttccca  11160
ttggaaagtt ggctccttaa gagtaggctg aagatgttac tggtcccacg tggtgcctta  11220
cttcctggta ctgttacagt ggcctctgtt gcaaggtgtt agatgagtgc ttgttgaatt  11280
catatctatg cagctcttaa cgtttttctg ttgcttctaa cccttccagt aggggaaaca  11340
gttggcacat attccagctt tggagaggaa atgcttgaag tctgtagcag ggtataattg  11400
ctgaattctt caagcgaatt aaagatctga atttgctcta gggcattcat aattatttta  11460
atttcctgga acagattcta agaattcatt ttaaatctga aagtttttct taaaatctgt  11520
tttatgatac actgtcttta tttttgtgaa tattgttagt ttctcacaac aatatttatt  11580
tcagttcatt tggatctaag atctttgttg tacttatgtg tggccagtag actctttagc  11640
aaaattaaac aaatgctaat gggttcccac agccacccaa atattagaag tacagctcca  11700
gattatgagc ctgtttctct ttttcttttc ttcttctcat tattttaaag agatggagtc  11760
tcagtatgtt gcttaggctg gtctcaaact cctgggctga agccattctc ccgcctcagc  11820
cttccaagta gctgggatta caggcaggag ccaccacccc agacatgaac ccacttctaa  11880
tgcaaaacac atattgacct gacaacaggg ccctcagttg tggtggaaag agcagtgacc  11940
ttggaattaa aagccctgtt gtgactcgtg gctttgccac ttttaaccaa ccctactttt  12000
atttacctat aatgtgcagg tatctgtctc actctttagg gatgccaaag gtgaaatgag  12060
gtgtgctgtc tatgtgacag tgccttgtga gcacttttct gacttctccc tgaggaggtt  12120
tgggtcaggc ctagcagaaa ctgcagccat agagcatgga gggaagtagg acttgactag  12180
cataaagtga gtctatgaga gtgtgcccac tggtttccaa agagaatgtc gaagagtcta  12240
caatggtgag gcctcatcag cctcgatttg agaagcaaat gtaggtcaga aatggggagc  12300
agaacaagag gaaaagaaga aggtcaggag tgtgcagagc tgaagaggtg gtgagaagtg  12360
gttcaaagct ggaaacaggc aaggtaatct ggaattctgt cttgatgtct attgagttat  12420
cctaaatcaa gactcatgtt cctcttacct tatatttctt aaattgattt gtttgatgcc  12480
ctgggtattt tgaagctcct agctgcataa tcttgcctaa taaaggcaca gaattagggc  12540
aaatagctgc agtgacttgt gtacctgctc agtgaaagcc aaagaatcaa tagctagaat  12600
ctgtgtccac aaattgctta caaaccacat gtagatatga cattcaacat caggcaaggc  12660
tgggcacggt ggctcagatc tgtaattcca gcactttggg aggccaaggc aggaggatca  12720
ctagagttca ggagtttgag accagcctgg gcaagatgat gagactcagt ctctacaaaa  12780
atgaaaaaaa aaatagctga gtgtggtggc atacacctgt agtcccacct ccttgggagg  12840
ctgaggtgag aggatcactt gagcccagga gtttgaggtt gcagtgagat atggtcatgc  12900
cactatattc cagcctgtct gcatgtaaaa acaaaaaata cacacacata cacacacacc  12960
ccagcctaac cacttaccac ctcttaatca tctgtataat ggacataaaa atgcctgcta  13020
tactttacat catagtattc ttgagtggag taaatgaaat aatgcatata aggtgctttg  13080
cacaatgtgt gcttgcctca caataaacac tcaatattat tagatatgat ttctaccatt  13140
attactaaca gtagtaagaa tagcagtagt atttaaaagc aagtttgcat tagttttaaa  13200
gcactatgaa atcccaagtc ttttttaaga cggagtctca ctttgttgcc caggctggag  13260
tgcagtggtg cagtctctgc tcactacaat ctccgcctcc cgggttcaag cgattctcct  13320
gcttcagcct cctgagtagc tctgattata ggtacccgcc accacaccca gctaattttt  13380
attttttagt agagacgggg ttttaccatg ttggccagac tggtctcaaa ctgctgacct  13440
caagtgatcc acctgcctcg gcctcccaaa gtgctaggat tacagggatg agccactgca  13500
cccggcctca agttatgatt gttaatattt ttgtgacatt caggataaat attttttagt  13560
atgctactga aggacatgtc tcagcatcgg tgtatccctt cctgaagcta tatgttacct  13620
tgcatttaca gagttgactt ggtgtccaga gaacaaatca gttgagaaaa ggccattttg  13680
aaaacgattt tttccaggga gcatacgcta gtaccctgtt gcggcatcca tgtgtgaggg  13740
ggtggttgga ttatagatct tcaatgtgaa gtcaagtttc ttatcaaatg aagtgttttg  13800
tccgatctta gagtttaaac ccacaaggag gtaacaaagc aaagggctaa tatatctttt  13860
cgctacttag aactacaggc cagaaatttg cttttgtatt ctgagatctt atgatacttg  13920
tctcaatgaa ataaaactgc atgcattatt ctgcatttcc atattactat tctctgtatt  13980
ggtaattatt atgatacttg cttcctgtac ttaaagcagc atgcagattt attttataat  14040
cacttcaagg aaagaaccag ttcctttgga gatttcctgt ggttccaaag ttgcatgcct  14100
ccaagtctgt taggttgtgg gattttgcat ttgagagaaa tgagggaggt ggagagaatg  14160
aagagaaagt ggactggcag aattacagaa tgtggtttca tctgatcttt taggctgagg  14220
gctactccat ttgtagactc catgcataaa actcaggcat cctgggtcct gccctactgc  14280
tgctttgtgg tcagaacatc gtgagatcat gcagcctcaa ggctgggaac atacgggatc  14340
aggtccaaca gcaggttgga gtttgggttc atgatttcaa agtcagggtc gtgagggcac  14400
ccaagatgat taccgagaag tcaaaagcac gtgccagtaa tggcaatgtg aaggtctggg  14460
aaacagccaa aacgtagctg tcaggaatgt gggacagagt ccctagggca gcttttccca  14520
aaacatgttc caagatatac tagctctatg ggatgttgac ttacaataat atgtggtgaa  14580
aaggttttcc agacaaacac tgagttcaga gttaagcagg tttttttcta ttgcagagct  14640
tgtcagagcc tctgatatgc ccactagtat tgtaagtgta caagatgaag ctttaaaatt  14700
gggcaaataa cagatatttc atacagaatc ctggatgtgg ccaggagtga tgggagatga  14760
aggatcctct tgtcagagta gcactccaca gaacacactt ggggaaaagt tgtcccaggg  14820
cctgtggcat gtgctctgaa ttcattttcg cctggctctt aattctgggg ttcggaagga  14880
actggcaaac acccacagaa gttatctagg atcttattga gtgcttcccc ctcgtccttc  14940
catccgaatc acttggctga tatttgttgc tgctattaac agaattcagg aaatcagccc  15000
ttcttagagg aagaaggaca agtgagacca caaacaacaa aacataatga atggatcaga  15060
gcctgtgtat aattggccct gaattaggca aataggcttt ccccactccc ttaaaatgaa  15120
aacaaaatgg tagtttaaag aaagtaccaa agggactata tctaataata acaatgagat  15180
tgaaaatgag ggcacatggt gtgtttaggg acggctgagg ccagtgaatg tcaaggcaga  15240
ctgcatcttt gacagcctcg cctcactggc tcctgaaatc ctcacacaca aaacagcatt  15300
cttcttgtgt tcttaaagtg aaaggcactg tttccctgtc acactagcaa tgttgcgaag  15360
taaatgtcat cctttcctcc tccttggccc tgccttctac agctagtgcc cctgccagtt  15420
gtttcctcag cacgtctcca gcgttcctct tctcttcccc ctcggcacgg ccttacttct  15480
ggtctcatca tcctatgcct gggctgatgc ctttgcttcc cagctgcagt cggctgggga  15540
tgaatgtggg gttaaggcag gcattccaga tatttataga attgttcatg gttcttttcc  15600
cattagccat gagttacttg agggtgaaga tagtgtctta tttgtctctc tgtctctagt  15660
aattagccaa gtacctggca cttttaatta aggagttatc actcagtaca tttaaatagg  15720
gagaaaaaga aaaaaacaaa gaatggaata aagtaaaagc atgataggtt ttgttactct  15780
ttttgcagtt gatcattggc tattcttaat tcttatagac cagttagtac tttagcagca  15840
tacagataag atatattaaa atcatacact gagtttttaa aaagtagatg ggcatgagtg  15900
gtggctcatg cctgtaatcc catcactttg ggagggcgag gcagtaggat cgcttgagcc  15960
caagagttcg agaccagcct gggcaaaata gtgggacccc gtctctacaa aatatttttt  16020
aaaaattagc cgggtgtgat ggtgcacctg ccgtcctagc tgcttgtgag gctgaagtga  16080
gaggatcact tgagcctgta aggtcagagc tgcagtgagc catgacagtg ccactgcact  16140
ccagcctggg cgacagagca agacactgtc tcaaaaaaaa aaaaaaaaaa aaagaaagag  16200
acaaaaagtt cattagcact taaacatgct tttcagaaaa tgactaatta tcaaaaacta  16260
gcaattgtga tactagcaaa tgaagaaacg tcaaatggag aagaaatgaa aaacgttttt  16320
agaatccagg acacacattt acaagaatgt aaaatattgt gaaaataatt tggaggagaa  16380
ttatgattaa attatttgag acttgaatta cctgcagtaa attcagctgc gtatcggttg  16440
ttaggcattt tatcattact aatcctgtta ccatctttgt tgaataagag attcatactt  16500
gatatacaag gtccatacat ttgtaaataa ttcattatta tattagtttg caagagtcat  16560
gattttgcca gaatttatcc aaaatggtct attggtaatc ccagagagta gcagaggcat  16620
tgggcagtga agctaacagg cggtgctaaa gccagcatga gcaagtgctg ggtggtagga  16680
aaatagaact caggcagtag tgagggcaaa taggagcaga cagggcagac ctagaaggag  16740
acagcaagta agaggcttag gaggctggag gagcagagac taaggaacgc tcccctggca  16800
tcatgcagca ttattacata agtgttagta atttcaaata gttataacta ttttagatat  16860
accatgtgct agctactgtt gtagtatgct cactagaatt taatacttga atcctcacag  16920
caacctaggt ggatactatt atgaatccta tgaattttca tttatagatg acaaaattga  16980
agtacaggga aagtaagtca ttcacccagc tgatcatcag taaatggaaa agccatgatt  17040
tgacctcagg aaaatgaggg ttatttgaca gggctgactt gaagaatgtt tagattgctg  17100
tagaactgta tttagtgctt aacgatatat aataactgat acaattggta tccaaacagc  17160
cgaatgtcat gcttttaggg atcaaggaaa gttgcctaag tgtgcatgtg cctagcattt  17220
gagttttgat acggatgatc ataccagaaa aatataccat cagttttcag gcctatctgc  17280
acagtaatat gcgtggagtt cttcatgatg tattcactga tattaaagct caaaactatt  17340
atgaatctta ggctctggcg aaaaaatgtg atcgtttaaa aattcggcat ttatcttatc  17400
ctgtggaatg ggcaacttct caggcccatt tgtcaccacc aacaaagcag taacacgagg  17460
tgttttaata aatctgttgc ccagtctctt ccatattgct atgcttagct gtaaaagaag  17520
ggaccaagaa atgggtgtta agctgaattg gaaacaattt tcagataaag cacagcagtc  17580
tgcgaacctc ctccagctca agatggtgtc aactagaatt gccttttgta agcaggcaga  17640
aagagacaca tgtacttgat tgtggtttct ctttactccc actttccact ctggtcatcc  17700
ctgtagacac agagtaattt gtgtactgta aatagctaga tctttctgta atctttattt  17760
gtttctttgt ttgttttttg agatggagtc tcacactgtc gcccaggctg gagtgcagtg  17820
gctcaatctc ggctcactgc aacctccacc tcctaggttc aagcgattct cctgcttcag  17880
cctcctgagt agctgggatt acaggcgccc gccgccatgc ccgactaatt tttgcatttt  17940
tttttttttt tttttttttt tgtagtagag acaatgtttc accatgttgg ctaggcttct  18000
ctcgaactcc tgacctcagg tgatccgcct gccttggcct ctcaaagtgc tgggattaca  18060
ggcgtgaacc accactctcg gctttaacca acattcttag ttgaacacag cagaaaggga  18120
aacctccatt agtacatgga actcgggcag tagtgagggc aaatatgagg gagagctgcc  18180
ttcctgttgc agtggtaagt tcagtctcta cctaagaaaa cagcatgcca aggtacagca  18240
gagcacactg gccagctcca atgcaagagt catcatggag tgtacctttt ttttttttga  18300
cagagtttcg ctcttgttgc ctaggctgga gtgcaatggc gcgatcttgg ctcaccgcaa  18360
cctccacctc ctgggttcaa gcgattctcc tacctcagcc tcttgagtag ctgggattac  18420
aggcatgcgc caccacgcct ggctaatttt tttttttttt tttttttgta tttttagtag  18480
agacagggtt tctccatgtt ggtcaggctg gtctcaaact ccctacctca ggtgatccac  18540
ccgcctcggc ctcccaaagt gctgggatta caagcatgag ccactgcacc tggccggagt  18600
atgcactttt aacatgtcta tgcagggaca catgtcctct aacaacaaat ggccatcccg  18660
agagtggtgg agcagagtgt tggacctctg gagcccaaat ttttattgta gcaatacaca  18720
gtcttcttat aacaggcact gtggccatgg gtcttatcag ctcctattca aaattggaat  18780
taggacaagt atagcaggtt gtgttctaac agaattctaa cttttaaggt gccacagaca  18840
ataatattct ttagaaatct tagtgttatc ctttttatcc tttcagggta gcaaacaaaa  18900
ggcactcagt aaataattat ggagtataat ttggggaaaa caaaatattt ctagtctgaa  18960
aattattgtt ttaaaaatta tttttgtctt gagaggctgt acatttctgt caactgcgtg  19020
gccacattgt tgatatgctt aagaaagata acagtcaaag ttgccttttt acactttgta  19080
tttgtgctca tccaaccatg agacctttaa aaatattgaa tatctgtagt tatctccctt  19140
caagtcttat tttgagttta tattaccttt gaactcaaaa gatctcaagc catttgcttt  19200
acctgacagt atgacattct ttaattttag gtagcattgt atgatgagtc tcaaatattg  19260
gcagcctata atgcatataa gttagtgatc ctagtaaatg taaataaaat aataaacaga  19320
aacatgctgg gcatggtggc ttatgcctgt aattccgtaa ctttgggagg ctgaggcagg  19380
aggattgctt cacaccagga gttagagacc agcttgggca acagaaaccc caatttttaa  19440
aaaatcagct gaacgtggtg gtgcatgcct gtagtcacag ctactcagga ggctgaggtg  19500
ggaggatcac ttgagctcag attgaggctg cagtgagttg tgagtgcacc tcagtctagg  19560
tggcagagtg aggtcctgtc tcaaaaacat aatgataaat gaaaataata acagaaacat  19620
tcagtcaata actgggattt ttttttactg ttactatttt ttatcaagac aaacatctgg  19680
agagttctac aattccagat gcttaccaat ctgcttctgg gttgtgaaaa aattatttgg  19740
gtatgtatag cttttaactt tttttttgtt tgttttaact gaatattgag gattttggta  19800
gaataacttt gaatgttttg gattttagat ttaaatggaa atatcaaatt ttatataggt  19860
tgggctctag atatttccat attgtcagaa tttagaaaac atcttttatg aaatagaaac  19920
taagaatttt ggcaaacaga gaaagttgcc caaggtctcc agaattcatt tgtttgacaa  19980
atacatattg agcatctacc ctgtgacagg tggtattcct gggatttgtc aggagcacaa  20040
ttgctgcctt cctggagctt acattctaac cagggaaaac tgacaataaa caataaaaaa  20100
agtaagtaaa taatgtagtt tgttagaaag ccataggtgc tacagaaaaa aataaactat  20160
aaagtagggg tcggactagc aataaaacta aatagtgtgg tcagggtagt ccatgtggac  20220
aagatgcaat ttgagccaag atttaaaaaa gataaagcaa ttagcctcaa aataatcggg  20280
gggaagaact ttccagcacc aagtagtttg ctcggcctgt tggaggaata gcaaggagcc  20340
agtgtgcctg gaatggaatg cccaaggggc aatagtggcc ataaggtaaa agtggtaatg  20400
gggctaaggc cagatcctat agagcttaca aactactgca aagaacttga gattttactc  20460
tcagtagaat gtggatccat tggagaattt taagcacagg atctgacttg ggttttaaaa  20520
gggtctctct ggtcctggtt tgacaatatg gactgcactg ggaacaaggg aaggagcagg  20580
ggtcttactg ctgtaattca gttaaaaatt atggtagttt aggctggaat agtagcacca  20640
gagatagtgc tagatggtaa aatctggaaa tattttgaaa gtagagccac caggatttcc  20700
tggtgaatag gatgtagagt atgagagaaa aagaggattt ggggtgtttc caaggtttta  20760
gcctgtgcat aaatggagtt attactattg attcagagaa aaccttaagg cagctacttt  20820
tagataagag ttgggtgatg aggggttcag atatgaatct gttgatagtg agatggctct  20880
tagacatact ggggaagatg ctggtaggca actgcatgtg taaatctgga gacgggtgag  20940
gtctgcagta gagatttaag tgtaggataa tctcaacatg tggaaggcat ggaagtgtgg  21000
gtgcaagtgg gagacgagaa ccaagcacta atccaagtgc acttcaatat ttaattttaa  21060
gagacaaggt cttttttttt tttttttttt cgagatggag tctcgctctg tcacccaggc  21120
tgaagtgcag tggcgccatc tcggctcact gcaagctccg cctcccggtt tcacgccatt  21180
ctcctgcctc agcctcccga gtagctggga ccacaggcgc ccaccaccac gcccggctaa  21240
tttttgtatt tttggtagag acggggtttc accgtgttag ccaggatggt ctcgatctcc  21300
tgacctcatg attcacctgc ctcagcctcc caaagtgcta ggattacagg cgtgagccac  21360
tgcgcccagc cgagacaagg tctttcactc tgttacagct ggagcacagt ggtgcaatca  21420
caggtcactg caatctcaaa ctcctgggct caagtaatct tcccaagtag ctaagactat  21480
aggtgtgcac caccatgccc agctaatttt tttttttact ttttgtagag atagtgtctt  21540
gctgtgttgc cgaagctagt ctcaaactct tatcttaagc agtcctctct ccgtggcgtc  21600
cctaagtgct gggattacag gcatgagcca tcatgcctgg ccaggcactt taattttaaa  21660
gagcctttaa tatggtttct tgccatgtca gagataagaa cagcttaata tttcttgact  21720
tttccttggt taaacaaggg gtatgcttta aaattttttt taattttaat tgtggtaaaa  21780
ggtacttaaa atttgccatc atagccattt ttaaatgtac atttcactgt cattaaatac  21840
attcaccact atcatccaca gaactcttca tcttgcaaaa ctgaattctg cacccactaa  21900
acaataactc ccttttcttc ttcctcccag gtcctcaaaa ccttcattcc attttctgtt  21960
tctatgattt taaagtggaa ttatacagta tttctctttt tgtaactggc ttatttcact  22020
tagcattatg tatgtcctca agattcatcc atgctgtagc atatgataga atttcctgct  22080
gggcgcagtg gctcacacct gtaatcccag cactttggga ggccaaggtg ggtggatcac  22140
ctgaagtcag gagttcgaga ccagcctggc cgacgtggtg aaaccctgtc tctactaaaa  22200
aatacaaaaa ttagctgcac atggtggtgg gcgacacagc ctcccaaagt gttgggatta  22260
caggtgtgag ctgctgcgcc aggcctgctt ctactctttg actattgtga attaatgctg  22320
ctgtgaacat ggatgtacaa atgtaaggga tatgtttttg ttttttgttt ttaagatgga  22380
gtctcactct gtcacctagg ctggtgtgca gtggcacagt cttggctcac tgcaacctcc  22440
gcctcccgga ttcaagcaat tctcccacct cagtctcctg agtagctgag attacaggta  22500
cccaccatca tgaccagcta ctttttgtat ttttagtaga aactgggttt caccatgttt  22560
cccaggctgg tcttgaactc ctgacctcag gtgatctgcc cgcctcaccc tcccaaagtg  22620
ttgggattac aggcctgcgc cacgatgccc agcagggata tgctttttta aaagtctctg  22680
tgatatgtat acttggtgac tttcatagat ttttaaaaat ataagtgata tataaataca  22740
tttttattat aaaagattta aatgatatag ctgttaacag accaaaatat gaaaattctc  22800
attcattctc tcacctcacc tccatctgca attcccaaag ttacatttgg tgtgctatct  22860
tccctctctt tcagtacatt tctatacatt tgtctataac ttattctttt taaaaactga  22920
gatattatac atattctaca gtttaataat gtcttggaga cctctcaatt atttatattt  22980
tggaaatatt cccagtctgc tgcatatgtt ctatagtgtt atatttacct ttacatgtac  23040
agggctatta ctgtagatta gagtcctaga agtgcatgca gttcctaggt ccaaggaact  23100
ttctttaact cttcatcaga ttttcttttt gaagaacctt tgtggcttga taattatgtt  23160
tctagaaaat ttattattca ggtttagaag tttggggagc tgtttgaaat aacactcaaa  23220
taaatttcct ggctatggat ttgttcccca tagcaagaga gttgtaaact atgagtttta  23280
taaccttaat gtcttttttt taaaaaaggc aattgatctc ttaatctagg tgttttagct  23340
agcatatggg agatgtaatc tgcaatctat gggacaaatg ggggagtttt gggagttatg  23400
atagaagact gttgaaaaat gttttataat aatgttttac agtagagaaa cctggtagat  23460
gccacctcat cagccgacca gggttaacat cacatgataa tcatattgct atcatgcagt  23520
gatattaata taataaagtg agatgggtgc attgcctctg tgatattctt accccaaacc  23580
cataaccaca gtctcataat gagaaaataa cagaaaccca atttgaggga cattccacaa  23640
aatacctgac catgttcttc aaaagtgcta tggtgccaaa agtcatgcaa gacaaatcta  23700
agtaattctc acaggttgta gtacactaag gagacagtga aaactaaatg caaataaagt  23760
ggtttttggt tttttaaagt atgtttatcc ttatggacaa tatgctccca taaagatcgt  23820
ctaccctaga aaactgtgtc ttccctctta aatccaagag atgcttgtcc caaagggtgg  23880
accccattga gatctcctgg gctagagacc cagtgcatgg atggatgaga cagtataagc  23940
aagaccgtat aaagctgtga tctgagctca tggacactgt ggtaagaggt caggctcgaa  24000
gaatcagaga actgagtgga ttttgcaatg gatagccaaa gagagggtcc aaacttaaaa  24060
tgcgaaacaa taattcaaga atgatttggt aaaatgtaat ataacagcct ataacagagt  24120
ctagcaaata gtagccaaaa gtcaccctaa ccaatcgtag ggcatatcta ccacacaaaa  24180
gtgtgactta gcgcatgact gtttaaatgc caaaaaagac agataaagga aagttaagcc  24240
atagtggcaa cctctgcagt tggaacgagg gagctatatc agtcaacagt gaggctaatt  24300
gagaatattt gaggttggcg tatgtctagg gattcctata ggagatacaa cccagcaagc  24360
ataggtcagc aacccaaggt cagagtacaa aatgggttaa tactaaaaag tggttaaaaa  24420
gatgaccagt cctcaagagg agatagtatt taaatcggat acctctcctt ccccatgcta  24480
actaacatac tgtaatttgt tatggctgtt tctaaggtaa ctgtttataa ttataaatca  24540
gccctactgg ttcttcttga tattgtaatt tgcaatcaaa gaacctctag agttaatgta  24600
aaacttcttg aatgagagac catctggtta caattttggt ttcaattccc tgttaggcaa  24660
ctgacaccca aataaggact gtttccaaat atgagtaggc taagtcagtc ataaacaaac  24720
aaaaagtttc agtttttgtt gctattatcc aagatgttag cagatgaagt gtttaatgaa  24780
agggtgcttc ttttaggcaa acttctttta ccatgatttg tttaacctat accagtggtc  24840
cgtacatttt tttcctgtaa agggccaaat aattattaat agtattttta gccttgcagc  24900
cacgtatgat ctctatgtat ttgtcattgc ctttttgttt ttttaaacaa atgtttaaaa  24960
atgtaaatgt tctctgtgtc cttcaccatg ttttcatgct ttgtgatagt ggctgaaatt  25020
tagagacttg ttttaataaa caatgttctg aaatgttgat ctaattgcct ctggcaaaag  25080
atgtgtaatc atgactttga tgaacttatt ttaaaaatag atgcacagtt gatctcttat  25140
tgcacgcatt ttggcacatt cgtgggagat attctctgta aacatgacac ttgcgaaacc  25200
taccataccc tgaaagtttg ctgtctagaa attaagtgcc tagttttcat tcaaattaat  25260
atttaggtaa gacatgtttt atttctaaat agactgtcaa acatttttca tattttaatg  25320
tgtaatggtg atgacctttt taaaaagact caacgtaatt tgttttctca tttaacccat  25380
taactgcccc ctttgtgtag tattgttgct gctttctctt ataaattgat gatgtctcag  25440
ggtctcaatt tacaattaca ttagtttctt cctctagttt gtagttgagc tgtggctctg  25500
cactgttggg gcctgtacag ccatccttca ctagaccccg ggaggtggcc tttagtaggc  25560
tcaaaggtgg cctttaagcc attcttagta tcactgtgaa aaagcatcca gattttcccc  25620
ctgaaaggcc aagtggttgc atgatgtgtt gtggatttta gggatatact ttgcctattt  25680
cacatacttt tttccaagaa gatagataag cttacacatg taaaggtttc aactgtattt  25740
cttctgttta taattttatt tattttgaga tggtgtctcg ctctgtcact cattttggag  25800
tgcagcgcaa tggtgtgatc acggctcact gtggcctcaa actcccaggt ttaagccatc  25860
ctcgcacctc ggccttctaa gtagctggga ctacagatgt atgccaccac acccagttaa  25920
tgttttttgt atttttttga agagacagga ttttgccatg gctgcctacc tggtctcaaa  25980
ctcctgggct taagtgatct gcctgcctca gcctcgcaaa gtgttgagat tacgtgagcc  26040
actgcaccca gcctttttat aattttaata ataatctgtc aatctttcat tacttttgcc  26100
ttctaaattc ttgttatatt ttactaaaca atgcttaatc tcgctgataa accattttag  26160
cagaagtatg tctgatgagg accacccctg cctttttttt tcttttctca gagttgcaag  26220
gtctccctct gttgaccagg ctggagtgca gtggtgtgat tatagctcac tgcttcctca  26280
acctcctggg ctcaagagat cctctcacct caacctcccc agtagctggg accacaagcg  26340
cgcaccacca tgcccagcta atttttattt tttttaagta aaggcagggt cttatgttgc  26400
ccaggctggt ctcaaattcc tagcgtcatt taatttctgt tttggtattg gctctgaaag  26460
aactgttgag acaatacttg gaactcttga tattttccaa aatctgtttt accaagataa  26520
attttaagga gagcaacaga aaataaagca gaaatgtggt ttctttgttg ggttttgttt  26580
tttttttttt tttttttttt tttgagatgg agtttcactc ttgttgccca ggctggagtg  26640
caatggtgcg atctcagctc actgcaacct ccccccatcc tgggttcagg tgattctcct  26700
gtctcaccct cctgagtagc taggattaca ggcgcccacc accacatctg gctaattttt  26760
gtatttttag tagagacggg gttttaccat gttggccagg ctggtcttga actcctgacc  26820
tcaggtgatc cacccgcctt ggcctcccag agtgctggga ttacaggcat gagccaccgc  26880
acctggccca aatgtggttt ctaatcaata ttatttaata atgaattgga ttaagaattt  26940
tttgggtttt ttttactcaa tagaaagttg attgggtttt ttaaaaatag cttgttttca  27000
ataattaagg cttaaaaaaa tctctgagtt ctctttgaga tatttggatt ctataaaaaa  27060
tgaaactctt tgtttcttaa ccaaatgata attccttaaa ttgcattctt tgattcaatt  27120
atactgaatt tcctggtaga aattttattt tctctgaagc agagtcagtg gtcttaatat  27180
caccatgtca accagaagag aaggaaatct aatatgcata atagagaaca ctgacacatg  27240
acttctttaa aagtctctga aattcaacat ataacttttt ataccagaaa gtgaacaaac  27300
atttaatcct tcctcttcat ctatgtctca tgatgtattt gtgtgatttt aaagaacatt  27360
ttggagtttt tgagttctat ataaatgtga ccatgttatc tgtataatct tgccatcctt  27420
tctttggaaa acatgggtca ccgttagcgt atgtcatgga tgttgatgtg gagtctgagt  27480
aagctagtgg gcgagagggt gtgtgtgtgg acgtgggcgc atgtgtgtat ttgttagttt  27540
caaatcgagc cattcttcta gagtctttag gtcagctgtc acgttgggct ttcctccttt  27600
gttcttttga gttgctctgt gactagccac agacccaaca ctaaaaagga aggcttttaa  27660
cggattaatt ccgtcctttc cttcgcctac attgtagcag ctgcgttctg ccctttctgt  27720
ggccctgcaa ggagaggagg cctgtgtata acagtcttct gtcaacatcc attataagat  27780
tcctaaagca catggaatga gatagttccc aggaaaactc tttgtcaagg ccagcccatg  27840
tgggaaaagt gtttctatgc ttagtcttgt aactatgact gtttttgttt tatggggtca  27900
ggggaaattt aacttatttt atttttcttt tttattgatc attcttgggt gtttctcgca  27960
gagggggatt tggcagggtc ataggacaat agtggaggga aggtcagcag ataaacaagt  28020
gaacaaaggt ctctggtttt cctaggcaga ggaccctgcg gccttccgca gtgtttgtgt  28080
ccctgggtac ttgagattag ggagtggtga tgattcttaa cgagcatgct gccttcaagc  28140
tctgtttaac aaagcacatc ctgcaccgcc cttaatccat ttaaccctga gtggacacag  28200
cacatgtttc agagagcaca gggttggggg taaaaggtca ccgatcaaca ggatcccaag  28260
gcagaagaat ttttcttagt acagaacaaa atgaaaagtc tcccatgtct acttctttct  28320
acacagacac ggcaaccatc cgacttctca atcttttccc cacctttccc ccctttctat  28380
tccacaaaac cgccattgtc atcccggccc gttctcaatg agctgttggg tacacctccc  28440
agacggggtg gtggccgggc agaggggctt ctcacatccc agtaggggcg gccgggcaga  28500
ggtgcccctc acctcccgga cggggcggct ggccgggcgg ggggctgaca cccccacctc  28560
cctcccggac ggggcggctg gccgggcggg gggctgaccc cccccacctc cctcccggac  28620
gggacggctg gcctggcggg ggctgacccc cacctccctc ccggatgggg tggctgccgg  28680
gcggagacgc tcctcacttc ccagaggggg tggctgccgg gcagaggggc tcctcacttc  28740
tcagacgggg cggttgccag gcggagggtc tcctcacttc tcagacgggg cggccgggca  28800
gagacgctcc tcacctccca gacggggtcg cggccgggca ggggcgctcc tcacatccca  28860
gacggggtgg cggggcagag gtgctcccca catctcagac gatgggcggc cgggcagaga  28920
cgctcctcag ttcctagatg ggatggcggc cgggaagagg cactcctcac ttcctagatg  28980
agatggcggc caggcagaga cactcctcac tttccagact gggcagccag gcagaggggc  29040
tcctcacgtc ccagacgatg ggcagccggg cagagacgct cctcacttcc cagacggggt  29100
ggcggccggg cagaggctgc aatctcggca ctttgggagg ccaaggcagg cggctgggag  29160
gtggaggttg tagcgagccg cgatcacgcc actgcactcc agcctgggca ccattgagca  29220
ctgagtgaac cagactccat ctgcaatccc ggcacctcgg gaggccgagg ctggcggatc  29280
actcgcggtt aggagctgga gaccagccca gccaacccag cgaaaccccg tctccaccaa  29340
aaaagtacga aaaccaatca ggcatggcgg cgcgggcatg taatcgcagg cactcggcag  29400
gctgaggcag gagaatcagg cagggaggtt gcagtgagcc gagatggcag cagtacagtc  29460
cagcttcggc tcggcatcag agggagaccg tggaaagaga gggagaccgt ggaaagggga  29520
gagggagagg gagggggagg gggagggaga gggagtggga gaggggaaat ttaacttata  29580
aggcagtatt gtgatatgcc tccatactta cctgcccttt ctttctgaac tcttgcagg   29639


<210>  204

<211>  8716
<212>  DNA
<213>  homo sapiens

<220>
<223>  TSPAN14 

<400>  204
gtgagtagag cgcggagacc tggctggggc gtcgggccct gcccctttct ttgtctgagg     60
ccgacttccc cgagcgttct ccgggggcga gggctgctcc ttaggtccct gtttggcccc    120
tcagcctccc tccccgcctg cccaggagcg gccccgcggg cggcgctggc tttgtctgcc    180
aggattgctc gctagaggtt ggaggcctcc gccgggaccc cgctgagccg aactccggcg    240
ccgcgcggac gagagccgcg gcgggcccgg ggccggcact cctggttcgg tagccctcgc    300
cccatcagcg cgccccggcg agtgcgcgcc cgtgccgggc ggggtgaggg cgacgggagc    360
ctggacggcc gctgctgctc ggggctctgc ttctcgtccc cagcagcgag ctcggggatg    420
ggccaccctt tcggctcagt cacccaccct cggctcccag gagatcgggt ccggggtggg    480
ggtgggcgta ggccggggcg ggccgcccct tcctcctgcc ccgccgtggt tgtgctcagt    540
ctcccacgcc gccgtgggtc ccactctgcc cggcttgggt ttgggacggc cggagtttga    600
gtaggcggtg acccagcttc tccgcgttag tcgtgtgggg ttgtgtttgg gagcaaagcc    660
tgacccctga cctagccgga gttctggtag agtgaggttt gtggctgcgg actgtgcttg    720
tcccgggccg ctgctgcttc tcctccaccc ccaggggtgg ggtgcgggtg ggtaggaagt    780
gcctgtgtga gggtgtgtgg agggactttg gccctgggac cgcaggagca cttgtcttgg    840
ggacttaaag ttgatctccg gcgagaaaca gtccgtgcta gggggagtcg ggggaagtcg    900
tgggcccggg tactggcctg gggctgggcg cagagcggtg gtgagtgcgg cggtgtcaca    960
cactcgttgg ctgtgctggc gctgctatcc gggaggtcag gcggtgctgg gcggctgtgc   1020
agagcattgt attggagcct ctgcaggtgt gctcttggca gtggtctgct ctccagggga   1080
tcttcctccc ttccgagagg gagttgctct tgggctagtg agagagtggc ctgccaaatc   1140
ctcaaaagta gccttcccct tgccccttga ccttgaagtc cagaagcagt tagtgcctgc   1200
tgagtgctcc ggccaccctt ctctatttgt gaagggaaac ctggggacag gccatcggag   1260
cacccctatg tccttgccac atttcagcta gccgagtggt tggtgggggc ggccgtcttt   1320
ccagggatct tcctgggccc tggcaccccc agaatgaagc ccagactcca ccataatggc   1380
cctgtatgcc cttctatccc cttagctgct ggtgtgatca tagcctcaaa ttgctgggct   1440
caagtgatcc tcccacctca gcctcccaaa gcacagggat tacaggtgtg agccaccacg   1500
cgcagtctga tcccactccg atccctaacg ttatagtgac aggccctgga aacccagggc   1560
caccagatgt attttccctt tccttctcat tgtgttgcac cccaacttca gttggagact   1620
ctggatatat ccatccccac atctctgaac tccactgctt gggccaccta atgtcatcct   1680
cagtttagtt aacaaagcat ggttgagatt tctgtggggt gcgaggcatt gttgcaggca   1740
ctattccaag tctggaaagt ccctcaccag ctatgaactt ggtgtggtct tagaacccag   1800
gctggacatg gcataggtgc tcagtagtgt ttattgatct gagcttgatc tcagcgtagc   1860
aggatcattt agggagacgg ggttgtgggg ggggtctgag cccatgggtg cttctgaagg   1920
tttgtggctg ccccaggaag aaagggcatg gagctgcaga atggttggct gcccagggaa   1980
ttgtcccctt caccagctgg gcagctgtgc tagtctctga ggactggtga aggtccttct   2040
catgtaggaa gtggcagtat gaagtgggag aggagatggc tctgccctga aggttgtggc   2100
ggcagtgaag tgaagttccc atggaggccg gggagcagga aagccctggg ttctggaact   2160
atttcctgag gcctcactct atgccaccat gtgctcagga atttgaccca tttaacttca   2220
actgaggtag aattcctttt agcagtgcct gcaaagtggc attgtgccag gcctgggaaa   2280
cctttgctgg cttaaaattt agtgaaggac aagattattt catagtgata ctaatgtgag   2340
tttattgaga cttacaccct agaagtttga cttgtaataa ctcatttaat ccttgaaaac   2400
agctgtgatg gctgggcgtg atggctcatg cctgtaatcc cagcactttg ggaggccgag   2460
gtgggtggat cacctgaggt caggagttca agaccagcct gaccaacacg gtgaaaccct   2520
gtctctacga aaaatacaaa attagctggg cgtggtggca catgcctata atcccagcta   2580
cttgggaggc tgaggcagga gaattgcttc aatctgggag gtggaggttg cagtgagctg   2640
agatcgcgcc gttgcactcc agcctgggca acaagaatga aactccatct caaaaaacaa   2700
aaaacaaaaa gcaaaacaac cgtgatgtca acagctccat tttacagatg aggaaactgt   2760
ggtcccgaga ggtcacagag taacttgctt gaagtctcaa tatgagctgg gttttctcat   2820
ttcttttttt ttgatactga gtctcactct attgcccagg ctggagtgca gtggcgtgat   2880
ctcggctcac tgcaacctcc gcctcctggg ttcaagtgat tcttctcctg cctcagcctc   2940
ccaagtagct tggactacag gtgtgcacca ccacacccag ctaatttttg tatttttagt   3000
agagatgggg tttcaccatg ttggccaggc tggtcttgaa ctcctgacct caagtgatcc   3060
gcccgcctcg gcctcccaaa gtgctgggat tacaggcgtg agccactgtg ccggaccagg   3120
ttttctcatt tctaatttag acaatatgtt cctctcagag gtgattaaaa tggattcata   3180
taccaaacaa gcctggccca cagtggaact aatgaatgtt ttcagtgaag gtgcccttgt   3240
atccctgcct ctgaacacat ctcatctgtc cagcacagcc tgggcacata gcaggtaccc   3300
cggaaccccc gctgattggt gatggagctt ctgtctccct aaggccaggg aatgggaaga   3360
ccagcactac cacatgcaga agattgggga gtcactgctt gtgtctgtct ggacagatca   3420
cggtttgctg tggtaacagc aatccccagg tctcagaggc ttaaagcaac agaggtttat   3480
ttcttgttca cactgcatgt tcatcactta tctgctttat gttgtcctca ctggggggac   3540
ccatagtgat tagtgggaac acccctggtg gcttggacag agggacagag aacatgatga   3600
tccctgtgtc ctgccactga gtcctggtgg cctttaagat gcctatggga aggggattag   3660
gttcctgctg cctgtctctg ccctgccgtg tcagtccttg gatatcttgc atgttccatc   3720
cgctacctgg atgtggcctg taggggcagc cacctttcct agaagcagga gcaggtagcg   3780
atacccaggc aggcctggtc ctccccactt ttgtgggact cggggattga gcttgcaggc   3840
ataggggtgt agaaagcagt ggtagcgagg tgactgaagg tggactccca ctggggatgg   3900
gattgagtgt ggggctagat ccctggtctg tagaagggag taggaaccct gttagttaaa   3960
ttttccccct caggccacgt tagtaggatt ttgaagagtc agccacactg tggctcttga   4020
ttttgtgcct ggtcacctgc ttggtctctg gtgatttccc tcggggccag cagacactgt   4080
tggaggtggt gaggcctcag gttcttctgc ttcatggtta actcactctg cttaggcata   4140
tttccacctt ttccagggcc tccgtttttc tgccagtgga ttgagaggtg gtggtggtct   4200
ccagcagtgg tctcactctt ggcaggctat cagagtaccc agggagctgc gtagaatgaa   4260
gttttgagag tctttggtct aggtgaatgc cagcgtttca gtttgcttat cttccattat   4320
agtagtgtcc tctgtaactg tgaatcaggg aggttattca taatatctcc acatccattt   4380
tctcccttaa ttgcgtatgc ttttgattta gacagggcaa gtagccattt tggtggagcg   4440
caggccctgg caggggggca gtgtccagtg ccgctctcaa ttaaacgtga agatgtgaag   4500
atgaataaca ctgtccagct tgcagagtgg acggtggtga ggcaagcttt caagttgcac   4560
ctactttcta gttgagtgac ctacacaagt ctttgatttt tttttttttt cttcctggaa   4620
aaaaaaagtt gtctactttt ctcatctgta aagtgagaag aatcaagtct gccttttctg   4680
tctcacgggg ttgcagtgaa gcattagtac cctgagaagc aagatccaaa gcccctgagt   4740
taggcctgac actggtgtga gacagctgcc atctctggcg gcactcagca agtgttcacc   4800
agcagctgat tctgggaacc tcacttcctc cgcccttggg cttggtgggg ttgggtaggg   4860
ttgggtgggg ctgtggtttt cttttaggag gcagcaggcc aggcctggag accagagctt   4920
aagtgggcct gggcaggctg gggttgaaac tcttcacccc ttgcggtctg tactgcctcc   4980
caactgagca gccagggaga aggcctagag cctgtgcctt tcagctagat agctggagga   5040
actggctcct ccctccttag gctgtgctgg cctgagctgg gagcctgaga gctggggcag   5100
ttgtctctaa agtggcttct gggattctgg taagaggtga gctcctggtg ctgcctcaga   5160
gtctttgtgt ttcctggcat ttgggagagc tggagttggg ctgtcctgca tgggtaaggt   5220
ttggggaggg actggaacaa ggggctagtg aaccttctct gggtttttcc tgcctgacta   5280
tgcgttgaca gtcccagctg ttgggcctgt gctcctgtac actgcacggc cttgagagga   5340
gttcggagcc ctaacatcca ggagagaggc cccacagcag tggaaggaaa tgggcctctc   5400
ccgaatctct tgtttgtacc ccgaggtctg agtggtgatc ctggggatgc tatgggactc   5460
tcagcagtag gagtgtgtct gtccccagtc tgggtgccca ccagctgtgc tgagggtcct   5520
ctcctgtgtc cctgggccag gcagacaggg tctttttctg gggcttgtta ggggaggtca   5580
gccacagccc cagaccaagt aatttacaca ccctgagtga ggggtgggag cagtgggtcc   5640
aggaagactt agggagctgg tgaaagaaaa acttaattct gacacttgtt aaactggtaa   5700
ggtagactgt atcaggacta ttacgataga tgtaggaatt atcgcaatgg attttgcagt   5760
agaggggaga gagtgggcca actccaaata caacaaagaa aagtgggaac ttatagccaa   5820
ggagcggagt gtgggggctc ctgaaaattt ctaagagggt agggaaattt ttactaaact   5880
tagctaactg aattcttgct gcaggcaggc cagggtgatc aggttttacc tgggagatag   5940
tacaggatga gaaatacgtt cagatatcca gggtgattag atattgaggt tgggggattc   6000
tggttaacag gagttttgct aaaactaggc tcttagagag aatggagtta ggaaccctag   6060
gtcaggacca gatgagtaga gggctcagag gaataaagtt tggtgaggga cagaatctct   6120
gtcagtatcc cgtggttggc agtgtcctgt ccattcttct tgcactggcc tgtccctcag   6180
gagacaggtg tgagtggtcc tgagcttggg ccagtgtaag agtaggggac aggtttctct   6240
ccttgtaggt gtcccttctt gtaagtgtca ctctcttttt ttccagaaac cttggtcctt   6300
ttcagcatct gctggcccct tgtcccttgg ctcccttgct cttggcctgc tggatttccc   6360
ctctgcaccc aggaaatcgc atggacctgg gtccttgttt ccctacagcc caccaatttt   6420
gctgcttttt tctgccccct gaagctgagc tcctgctgca atttgtgttc cctgctctcc   6480
ctgtcctggg caaaccagtc tgacaacttt gtggttctcg ctcccgcctc catcagcctg   6540
gggattgact gtcccatttg tctgagctgg gcagagggag gtgctgtggg ggatctcttc   6600
ctcttgcctg gactgcacac tcctgctgcc ttctagccgg agctcctggg cattttgcct   6660
atgggagctt caccagcttc cttctgtctg aggcctacaa gtccctgcct ccagcctacc   6720
ttgttcctcc tccatgagtg aggctcctcc ttttctctct ggccctcctg tctacttgat   6780
cagactctgc ctctcttgag ggccggctcc ctccagccta ccctgcacag gtgaccctgt   6840
ttggcctgcc tccttttctt gaggctgatc ttgtctcaac agtcagcttt tcaggaacca   6900
ggcccttgct gttgtaagga aaacctgtcg gctgtggatg gggccttccc tccttcctaa   6960
aggctctgta gccagcttcc acccttgcag tggaacagtg gtggtgccag aaccctgctc   7020
tctgcagcca tcctgcctac cacagtcatt gtgttttgta actctagtag cttcttgtga   7080
aatacaagtg atggtataaa cgtggatagg tttttgaggg gggcatgcca aaatcagagt   7140
tggtggtagt ggtgggggat tcattcccaa gggctctggg gtgctaagtg tgtgagcaaa   7200
gaggaacaag tggcatgtgc ccaggatggg gtggggcggg caggtttagt tgagggctcc   7260
tctggtgtag ggtagccctg acgctcccct ccatggcatg actgatgagg tggcaaaggc   7320
aggtgccagg atttggtgtg ttgaagatta gtgcctgggt tgggctctgc tcactcctgc   7380
agaaagacgg ttggagaggg gctggtcttg gtttcacaga ggattgtggg attacaggca   7440
agacctgctg agggcttgca ctgagccacc gagaggagca gaaagagata cgagggcttc   7500
aggtgccagt atggttctca ctgttgtgag atctcatttg tgcctttttt ttttttcctt   7560
cagacagggt ctcactctgt tgcccaggct ggagtgcagt ggccctatca cagctcactg   7620
aggcctccac cttcctggct caagtgatcc tcccgcctca gcctcctgag tagcagggac   7680
cacaggcatg cagcaccaca cccagctaat ttaaagaatt ttttgtagag attggatctt   7740
gctatgttgc ctaggctggt gtcaaactcc tgggcacttg atttgtgctt cttaattcag   7800
gggctactta ttgaacatat ttagcagtct tcagaaagca tcttattctg taaggggaac   7860
caaatatacc cattccccct ctctggcctt ctttccctgt ggtctgggcg gtctttgagc   7920
ttgaggtcat taggaggtgt ttatttctgt ccgccctggt ggcctagggc gtaggaatgg   7980
ggtgggatgg gatgggatgg ggtggggtgg ggtggaggag ttattctaca tagatagagt   8040
tctgtttatg cagcactccc tgccatacac atctctcact caaatggtct ggccagtcct   8100
ggttctaatg gtcattgtgt cattcccctc agcagcagga aaggctggaa tggtttttgt   8160
attgttcctt agggggaaaa atcacttgga ggaagtatat cagtgcttct gagtgcagag   8220
tatttattga cacgtcagtt aaaggaagct tttaaacaac atatatgtat ctctttagtg   8280
aggaataaat ctacaagtgc atctcacagc tccattttgc agcttccatt tcctggaagg   8340
tacatggagt ttagtggtta gggaatgggg ttttgagctg ggattttgga gaaactgttt   8400
ttagcctgtc cttggaattg ggccaggcct agaaatctgt tgaaatagct ttctttagtt   8460
gctgaaactg ggatgtgttc atagcactag gacctcgagc tccactgatg actgagtggg   8520
gagggctcag agaagggtcc ctgtggatgc ccgggatgcc tgggtttcag tcccgtctcc   8580
tgcatcgcct acattgcctg aatcttaggg tcttacagat ttatcatgaa gtgggcttgg   8640
cagcagatgg tctggtttct tttgtgcctt tgtcagaatc tgttcttgct cttcttagga   8700
aaactttcta tttcag                                                   8716


<210>  205

<211>  3812
<212>  DNA
<213>  homo sapiens

<220>
<223>  B2M

<400>  205
gcgtgagtct ctcctaccct cccgctctgg tccttcctct cccgctctgc accctctgtg     60
gccctcgctg tgctctctcg ctccgtgact tcccttctcc aagttctcct tggtggcccg    120
ccgtggggct agtccagggc tggatctcgg ggaagcggcg gggtggcctg ggagtgggga    180
agggggtgcg cacccgggac gcgcgctact tgcccctttc ggcggggagc aggggagacc    240
tttggcctac ggcgacggga gggtcgggac aaagtttagg gcgtcgataa gcgtcagagc    300
gccgaggttg ggggagggtt tctcttccgc tctttcgcgg ggcctctggc tcccccagcg    360
cagctggagt gggggacggg taggctcgtc ccaaaggcgc ggcgctgagg tttgtgaacg    420
cgtggagggg cgcttggggt ctgggggagg cgtcgcccgg gtaagcctgt ctgctgcggc    480
tctgcttccc ttagactgga gagctgtgga cttcgtctag gcgcccgcta agttcgcatg    540
tcctagcacc tctgggtcta tgtggggcca caccgtgggg aggaaacagc acgcgacgtt    600
tgtagaatgc ttggctgtga tacaaagcgg tttcgaataa ttaacttatt tgttcccatc    660
acatgtcact tttaaaaaat tataagaact acccgttatt gacatctttc tgtgtgccaa    720
ggactttatg tgctttgcgt catttaattt tgaaaacagt tatcttccgc catagataac    780
tactatggtt atcttctgcc tctcacagat gaagaaacta aggcaccgag attttaagaa    840
acttaattac acaggggata aatggcagca atcgagattg aagtcaagcc taaccagggc    900
ttttgcggga gcgcatgcct tttggctgta attcgtgcat ttttttttaa gaaaaacgcc    960
tgccttctgc gtgagattct ccagagcaaa ctgggcggca tgggccctgt ggtcttttcg   1020
tacagagggc ttcctctttg gctctttgcc tggttgtttc caagatgtac tgtgcctctt   1080
actttcggtt ttgaaaacat gagggggttg ggcgtggtag cttacgcctg taatcccagc   1140
acttagggag gccgaggcgg gaggatggct tgaggtccgt agttgagacc agcctggcca   1200
acatggtgaa gcctggtctc tacaaaaaat aataacaaaa attagccggg tgtggtggct   1260
cgtgcctgtg gtcccagctg ctccggtggc tgaggcggga ggatctcttg agcttaggct   1320
tttgagctat catggcgcca gtgcactcca gcgtgggcaa cagagcgaga ccctgtctct   1380
caaaaaagaa aaaaaaaaaa aaagaaagag aaaagaaaag aaagaaagaa gtgaaggttt   1440
gtcagtcagg ggagctgtaa aaccattaat aaagataatc caagatggtt accaagactg   1500
ttgaggacgc cagagatctt gagcactttc taagtacctg gcaatacact aagcgcgctc   1560
accttttcct ctggcaaaac atgatcgaaa gcagaatgtt ttgatcatga gaaaattgca   1620
tttaatttga atacaattta tttacaacat aaaggataat gtatatatca ccaccattac   1680
tggtatttgc tggttatgtt agatgtcatt ttaaaaaata acaatctgat atttaaaaaa   1740
aaatcttatt ttgaaaattt ccaaagtaat acatgccatg catagaccat ttctggaaga   1800
taccacaaga aacatgtaat gatgattgcc tctgaaggtc tattttcctc ctctgacctg   1860
tgtgtgggtt ttgtttttgt tttactgtgg gcataaatta atttttcagt taagttttgg   1920
aagcttaaat aactctccaa aagtcataaa gccagtaact ggttgagccc aaattcaaac   1980
ccagcctgtc tgatacttgt cctcttctta gaaaagatta cagtgatgct ctcacaaaat   2040
cttgccgcct tccctcaaac agagagttcc aggcaggatg aatctgtgct ctgatccctg   2100
aggcatttaa tatgttctta ttattagaag ctcagatgca aagagctctc ttagctttta   2160
atgttatgaa aaaaatcagg tcttcattag attccccaat ccacctcttg atggggctag   2220
tagcctttcc ttaatgatag ggtgtttcta gagagatata tctggtcaag gtggcctggt   2280
actcctcctt ctccccacag cctcccagac aaggaggagt agctgccttt tagtgatcat   2340
gtaccctgaa tataagtgta tttaaaagaa ttttatacac atatatttag tgtcaatctg   2400
tatatttagt agcactaaca cttctcttca ttttcaatga aaaatataga gtttataata   2460
ttttcttccc acttccccat ggatggtcta gtcatgcctc tcattttgga aagtactgtt   2520
tctgaaacat taggcaatat attcccaacc tggctagttt acagcaatca cctgtggatg   2580
ctaattaaaa cgcaaatccc actgtcacat gcattactcc atttgatcat aatggaaagt   2640
atgttctgtc ccatttgcca tagtcctcac ctatccctgt tgtattttat cgggtccaac   2700
tcaaccattt aaggtatttg ccagctcttg tatgcattta ggttttgttt ctttgttttt   2760
tagctcatga aattaggtac aaagtcagag aggggtctgg catataaaac ctcagcagaa   2820
ataaagaggt tttgttgttt ggtaagaaca taccttgggt tggttgggca cggtggctcg   2880
tgcctgtaat cccaacactt tgggaggcca aggcaggctg atcacttgaa gttgggagtt   2940
caagaccagc ctggccaaca tggtgaaatc ccgtctctac tgaaaataca aaaattaacc   3000
aggcatggtg gtgtgtgcct gtagtcccag gaatcacttg aacccaggag gcggaggttg   3060
cagtgagctg agatctcacc actgcacact gcactccagc ctgggcaatg gaatgagatt   3120
ccatcccaaa aaataaaaaa ataaaaaaat aaagaacata ccttgggttg atccacttag   3180
gaacctcaga taataacatc tgccacgtat agagcaattg ctatgtccca ggcactctac   3240
tagacacttc atacagttta gaaaatcaga tgggtgtaga tcaaggcagg agcaggaacc   3300
aaaaagaaag gcataaacat aagaaaaaaa atggaagggg tggaaacaga gtacaataac   3360
atgagtaatt tgatgggggc tattatgaac tgagaaatga actttgaaaa gtatcttggg   3420
gccaaatcat gtagactctt gagtgatgtg ttaaggaatg ctatgagtgc tgagagggca   3480
tcagaagtcc ttgagagcct ccagagaaag gctcttaaaa atgcagcgca atctccagtg   3540
acagaagata ctgctagaaa tctgctagaa aaaaaacaaa aaaggcatgt atagaggaat   3600
tatgagggaa agataccaag tcacggttta ttcttcaaaa tggaggtggc ttgttgggaa   3660
ggtggaagct catttggcca gagtggaaat ggaattggga gaaatcgatg accaaatgta   3720
aacacttggt gcctgatata gcttgacacc aagttagccc caagtgaaat accctggcaa   3780
tattaatgtg tcttttcccg atattcctca gg                                 3812


<210>  206

<211>  2052
<212>  DNA
<213>  homo sapiens

<220>
<223>  HBB

<400>  206
ccctgtggag ccacacccta gggttggcca atctactccc aggagcaggg agggcaggag     60
ccagggctgg gcataaaagt cagggcagag ccatctattg cttacatttg cttctgacac    120
aactgtgttc actagcaacc tcaaacagac accatggtgc acctgactcc tgaggagaag    180
tctgccgtta ctgccctgtg gggcaaggtg aacgtggatg aagttggtgg tgaggccctg    240
ggcaggttgg tatcaaggtt acaagacagg tttaaggaga ccaatagaaa ctgggcatgt    300
ggagacagag aagactcttg ggtttctgat aggcactgac tctctctgcc tattggtcta    360
ttttcccacc cttaggctgc tggtggtcta cccttggacc cagaggttct ttgagtcctt    420
tggggatctg tccactcctg atgctgttat gggcaaccct aaggtgaagg ctcatggcaa    480
gaaagtgctc ggtgccttta gtgatggcct ggctcacctg gacaacctca agggcacctt    540
tgccacactg agtgagctgc actgtgacaa gctgcacgtg gatcctgaga acttcagggt    600
gagtctatgg gacccttgat gttttctttc cccttctttt ctatggttaa gttcatgtca    660
taggaagggg agaagtaaca gggtacagtt tagaatggga aacagacgaa tgattgcatc    720
agtgtggaag tctcaggatc gttttagttt cttttatttg ctgttcataa caattgtttt    780
cttttgttta attcttgctt tctttttttt tcttctccgc aatttttact attatactta    840
atgccttaac attgtgtata acaaaaggaa atatctctga gatacattaa gtaacttaaa    900
aaaaaacttt acacagtctg cctagtacat tactatttgg aatatatgtg tgcttatttg    960
catattcata atctccctac tttattttct tttattttta attgatacat aatcattata   1020
catatttatg ggttaaagtg taatgtttta atatgtgtac acatattgac caaatcaggg   1080
taattttgca tttgtaattt taaaaaatgc tttcttcttt taatatactt ttttgtttat   1140
cttatttcta atactttccc taatctcttt ctttcagggc aataatgata caatgtatca   1200
tgcctctttg caccattcta aagaataaca gtgataattt ctgggttaag gcaatagcaa   1260
tatttctgca tataaatatt tctgcatata aattgtaact gatgtaagag gtttcatatt   1320
gctaatagca gctacaatcc agctaccatt ctgcttttat tttatggttg ggataaggct   1380
ggattattct gagtccaagc taggcccttt tgctaatcat gttcatacct cttatcttcc   1440
tcccacagct cctgggcaac gtgctggtct gtgtgctggc ccatcacttt ggcaaagaat   1500
tcaccccacc agtgcaggct gcctatcaga aagtggtggc tggtgtggct aatgccctgg   1560
cccacaagta tcactaagct cgctttcttg ctgtccaatt tctattaaag gttcctttgt   1620
tccctaagtc caactactaa actgggggat attatgaagg gccttgagca tctggattct   1680
gcctaataaa aaacatttat tttcattgca atgatgtatt taaattattt ctgaatattt   1740
tactaaaaag ggaatgtggg aggtcagtgc atttaaaaca taaagaaatg atgagctgtt   1800
caaaccttgg gaaaatacac tatatcttaa actccatgaa agaaggtgag gctgcaacca   1860
gctaatgcac attggcaaca gcccctgatg cctatgcctt attcatccct cagaaaagga   1920
ttcttgtaga ggcttgattt gcaggttaaa gttttgctat gctgtatttt acattactta   1980
ttgttttagc tgtcctcatg aatgtctttt cactacccat ttgcttatcc tgcatctctc   2040
tcagccttga ct                                                       2052

<210>  207

<211>  147
<212>  PRT
<213>  homo sapiens

<220>
<223>  HBB

<400>  207
Met Val His Leu Thr Pro Glu Glu Lys Ser Ala Val Thr Ala Leu Trp 
1               5                   10                  15      


Gly Lys Val Asn Val Asp Glu Val Gly Gly Glu Ala Leu Gly Arg Leu 
            20                  25                  30          


Leu Val Val Tyr Pro Trp Thr Gln Arg Phe Phe Glu Ser Phe Gly Asp 
        35                  40                  45              


Leu Ser Thr Pro Asp Ala Val Met Gly Asn Pro Lys Val Lys Ala His 
    50                  55                  60                  


Gly Lys Lys Val Leu Gly Ala Phe Ser Asp Gly Leu Ala His Leu Asp 
65                  70                  75                  80  


Asn Leu Lys Gly Thr Phe Ala Thr Leu Ser Glu Leu His Cys Asp Lys 
                85                  90                  95      


Leu His Val Asp Pro Glu Asn Phe Arg Leu Leu Gly Asn Val Leu Val 
            100                 105                 110         


Cys Val Leu Ala His His Phe Gly Lys Glu Phe Thr Pro Pro Val Gln 
        115                 120                 125             


Ala Ala Tyr Gln Lys Val Val Ala Gly Val Ala Asn Ala Leu Ala His 
    130                 135                 140                 


Lys Tyr His 
145         


<210>  208

<211>  1000
<212>  DNA
<213>  homo sapiens

<220>
<223>  CD40L

<400>  208
gaattcactg gggagagcat tcaggaagat gacaacagga taataggtca acagagtaat     60
agagaggtcg ctaaaaataa actctaagaa gtattcagcc aaaactatta ttgagctaat    120
aatggtggga tcaatttcag gggaatattg tgggcagaag tcagactgta ggaggctggg    180
gatcaagaag ttgaggcaag gaggttggac aacaactgtt ttttcaagtt ggtcacgtga    240
acaaatctgt gaccttcagc ctcccctccc tcgggtcttg gctgagctga ttgcagggcc    300
cctgcagctc tggcactctc aagttgtata aaactgacag tgcagaagtc cttgagccca    360
ttttggctct catgataatt ttccttcagt ggaactaagg ttacttgtct aagaaccaaa    420
gcctctgact tgactgatca aagttcatca cgtgcatcga agccacctac ttggcagatg    480
tagtgaaaag ctacatagat ctgggcccag gacaggatgc tggggcgtgg gaggggaaga    540
aagcaggtgc taactatata gatagcatgc ctatcagagc agtttttacg tttcctattt    600
gtctctcaaa acaattttat aggaatcatc aaagcaattt tatcatggtt tctagaccag    660
gtttggatgt gaggtaggga tttccacagc tgcttttagt ttgaaggaaa tctgataaga    720
tgatgcaaaa gcccttcaga aatgtgtaat cctacacact tcagtgattc aattcattgt    780
caaaacttaa ggtgttttta atattgttat tgttcatttg gtttttacca acatgtaagg    840
agttggcaat tatttgttaa actcatgtct taggctaaat aaattccaaa aaattcagga    900
tgagaattgt ttattgctta acgtgtgtca aatttcttcc atgcacatct ttattagatc    960
ttcacagcaa cctacaggat aagcaagaca ggtgcaagtg                         1000


<210>  209

<211>  261
<212>  PRT
<213>  homo sapiens

<220>
<223>  CD40L

<400>  209
Met Ile Glu Thr Tyr Asn Gln Thr Ser Pro Arg Ser Ala Ala Thr Gly 
1               5                   10                  15      


Leu Pro Ile Ser Met Lys Ile Phe Met Tyr Leu Leu Thr Val Phe Leu 
            20                  25                  30          


Ile Thr Gln Met Ile Gly Ser Ala Leu Phe Ala Val Tyr Leu His Arg 
        35                  40                  45              


Arg Leu Asp Lys Ile Glu Asp Glu Arg Asn Leu His Glu Asp Phe Val 
    50                  55                  60                  


Phe Met Lys Thr Ile Gln Arg Cys Asn Thr Gly Glu Arg Ser Leu Ser 
65                  70                  75                  80  


Leu Leu Asn Cys Glu Glu Ile Lys Ser Gln Phe Glu Gly Phe Val Lys 
                85                  90                  95      


Asp Ile Met Leu Asn Lys Glu Glu Thr Lys Lys Glu Asn Ser Phe Glu 
            100                 105                 110         


Met Gln Lys Gly Asp Gln Asn Pro Gln Ile Ala Ala His Val Ile Ser 
        115                 120                 125             


Glu Ala Ser Ser Lys Thr Thr Ser Val Leu Gln Trp Ala Glu Lys Gly 
    130                 135                 140                 


Tyr Tyr Thr Met Ser Asn Asn Leu Val Thr Leu Glu Asn Gly Lys Gln 
145                 150                 155                 160 


Leu Thr Val Lys Arg Gln Gly Leu Tyr Tyr Ile Tyr Ala Gln Val Thr 
                165                 170                 175     


Phe Cys Ser Asn Arg Glu Ala Ser Ser Gln Ala Pro Phe Ile Ala Ser 
            180                 185                 190         


Leu Cys Leu Lys Ser Pro Gly Arg Phe Glu Arg Ile Leu Leu Arg Ala 
        195                 200                 205             


Ala Asn Thr His Ser Ser Ala Lys Pro Cys Gly Gln Gln Ser Ile His 
    210                 215                 220                 


Leu Gly Gly Val Phe Glu Leu Gln Pro Gly Ala Ser Val Phe Val Asn 
225                 230                 235                 240 


Val Thr Asp Pro Ser Gln Val Ser His Gly Thr Gly Phe Thr Ser Phe 
                245                 250                 255     


Gly Leu Leu Lys Leu 
            260     

<210>  210

<211>  3435
<212>  DNA
<213>  homo sapiens

<220>
<223>  ADCY3

<400>  210
atgccgagga accagggctt ctccgagccc gaatactcgg ccgagtactc agccgagtac     60
tccgtcagcc tgccctccga ccctgaccgc ggggtgggcc ggacccatga aatctcggtc    120
cggaactcgg gctcctgcct gtgcctgcct cgcttcatgc ggctgacttt cgtgccggag    180
tccttggaga acctctacca gacctacttc aaaaggcagc gccacgagac cctgctggtg    240
ctggtggtct ttgcagccct ctttgactgc tacgtggtgg tcatgtgtgc tgtggtcttc    300
tccagcgaca agctggcttc cctcgccgtg gctggaattg gactggtgtt ggacatcatc    360
ctcttcgtgc tctgcaaaaa ggggctgctc ccggaccggg tcacccgcag agtgctgccc    420
tacgtgctgt ggctgctcat aaccgcccag atcttctcct acctgggcct gaacttcgcg    480
cgtgcccacg cggctagtga cacggtgggc tggcaggtct tctttgtctt ctccttcttc    540
atcacgctgc ccctcagcct cagccccatc gtgatcatct ccgtggtctc ctgtgtggtg    600
cacacgttgg tcctgggggt caccgtggcc cagcagcagc aggaggagct caaggggatg    660
cagctgctgc gggagatcct ggccaacgtc ttcctctacc tgtgcgccat cgctgtgggc    720
atcatgtcct actacatggc tgaccgcaag caccgcaagg ccttcctgga ggcccgccag    780
tcgctggagg tgaagatgaa cctggaagag cagagccagc agcaggagaa cctcatgctt    840
tccatcctgc ccaagcacgt ggctgacgag atgctgaaag acatgaagaa agacgagagc    900
cagaaggacc agcagcagtt caacaccatg tacatgtacc gtcacgagaa cgtcagcatc    960
ctctttgccg acatcgtggg ctttacccag ctgtcttctg cctgcagtgc ccaggagctt   1020
gtgaagctgc tcaacgagct ctttgcccgc tttgacaagc tggcagctaa ataccaccag   1080
ctgcggatta agatcctggg cgactgctac tactgcatct gcggcttgcc cgactaccgg   1140
gaggaccacg ccgtctgctc catcctcatg gggctggcca tggtggaggc catctcgtat   1200
gtgcgggaga agaccaagac tggggtggac atgcgtgtgg gggtgcacac gggcaccgtg   1260
ctggggggcg tcctgggcca gaagcgctgg cagtacgacg tgtggtcgac tgatgtcact   1320
gtagccaaca agatggaggc cggcggcatc cctgggcgcg tgcacatctc ccagagcacc   1380
atggactgcc tgaaagggga gtttgatgtg gagccaggcg atgggggcag ccgctgtgat   1440
tacctagaag agaagggtat tgaaacctac ctcatcattg cctccaagcc agaggtgaag   1500
aaaacagcca cccagaatgg cctcaatggc tcggccctgc ccaatggagc accagcttcc   1560
tcaaagtcca gctcccctgc cctcattgag accaaggagc ccaacgggag tgcccacagc   1620
agtgggtcca cgtcggagaa gcccgaggag caggatgccc aggccgacaa cccctcattc   1680
cccaacccac gccggaggct gcgcctgcag gacctggctg accgagtggt ggatgcctct   1740
gaagatgagc acgagctcaa ccagctgctc aacgaggccc tgcttgagcg agagtccgcc   1800
caagtagtaa agaagagaaa caccttcctc ttgtccatgc ggttcatgga ccccgagatg   1860
gaaacccgct actcggtgga gaaggagaag cagagtgggg ctgccttcag ctgctcctgc   1920
gtcgtcctgc tctgcacggc cctggtcgag atactcatcg acccctggct aatgacaaac   1980
tatgtgacct tcatggtggg ggagattctg ctcctcatcc tgaccatctg ctccctggct   2040
gccatctttc cccgggcctt tcctaagaag cttgtggcct tctcaacttg gattgaccgg   2100
acccgctggg ccaggaacac ctgggccatg ctcgccatct tcatcctggt gatggcaaat   2160
gtcgtggaca tgctcagctg tctccagtac tacacgggac ccagcaatgc aacggcaggg   2220
atggaaacgg agggcagctg cctggagaac cccaagtatt acaactatgt ggccgtgctg   2280
tccctcatcg ccaccatcat gctggtgcag gtcagccaca tggtgaagct cacgctcatg   2340
ctgctcgtcg caggcgccgt ggccaccatc aacctctatg cctggcgtcc cgtctttgat   2400
gaatacgacc acaagcgttt tcgggagcac gacttaccta tggtggcctt agagcagatg   2460
caaggattca accctgggct caatggcact gacaggctgc ccctggtgcc ttccaagtac   2520
tctatgacgg tgatggtgtt cctcatgatg ctcagcttct actacttctc ccgccacgta   2580
gaaaaactgg cacggacact tttcttgtgg aagattgagg tccacgacca gaaggaacgt   2640
gtctatgaga tgcgacgctg gaacgaggcc ttggtcacca acatgttgcc tgagcacgtg   2700
gcacgccatt tcctggggtc caagaagaga gatgaggagc tgtatagcca gacgtatgat   2760
gagattggag tcatgtttgc ctccctgccc aactttgctg acttctacac agaggagagc   2820
atcaacaatg gtggtattga gtgtctgcgt ttcctcaatg aaatcatctc agattttgac   2880
tctctcctgg acaatcccaa gttccgggtg atcaccaaga tcaaaaccat tggcagcacg   2940
tatatggcgg cttcaggagt cacccccgat gtcaacacca atggctttgc cagctccaac   3000
aaggaagaca agtccgagag agagcgctgg cagcacctgg ctgacctggc cgacttcgcg   3060
ctggccatga aggatacgct caccaacatc aacaaccagt ccttcaataa cttcatgctg   3120
cgcataggca tgaacaaagg cggggttctg gctggggtca tcggagcccg gaaaccacac   3180
tacgacatct ggggcaatac agtcaatgta gccagcagga tggagtccac gggggtcatg   3240
ggcaacattc aggtggtaga agaaacccaa gtcatcctcc gagagtacgg cttccgcttt   3300
gtgaggcgag gccccatctt tgtgaagggg aagggggagc tgctgacctt cttcttgaag   3360
gggcgggata agctagccac cttccccaat ggcccctctg tcacactgcc ccaccaggtg   3420
gtggacaact cctga                                                    3435


<210>  211

<211>  1144
<212>  PRT
<213>  homo sapiens

<220>
<223>  ADCY3

<400>  211
Met Pro Arg Asn Gln Gly Phe Ser Glu Pro Glu Tyr Ser Ala Glu Tyr 
1               5                   10                  15      


Ser Ala Glu Tyr Ser Val Ser Leu Pro Ser Asp Pro Asp Arg Gly Val 
            20                  25                  30          


Gly Arg Thr His Glu Ile Ser Val Arg Asn Ser Gly Ser Cys Leu Cys 
        35                  40                  45              


Leu Pro Arg Phe Met Arg Leu Thr Phe Val Pro Glu Ser Leu Glu Asn 
    50                  55                  60                  


Leu Tyr Gln Thr Tyr Phe Lys Arg Gln Arg His Glu Thr Leu Leu Val 
65                  70                  75                  80  


Leu Val Val Phe Ala Ala Leu Phe Asp Cys Tyr Val Val Val Met Cys 
                85                  90                  95      


Ala Val Val Phe Ser Ser Asp Lys Leu Ala Ser Leu Ala Val Ala Gly 
            100                 105                 110         


Ile Gly Leu Val Leu Asp Ile Ile Leu Phe Val Leu Cys Lys Lys Gly 
        115                 120                 125             


Leu Leu Pro Asp Arg Val Thr Arg Arg Val Leu Pro Tyr Val Leu Trp 
    130                 135                 140                 


Leu Leu Ile Thr Ala Gln Ile Phe Ser Tyr Leu Gly Leu Asn Phe Ala 
145                 150                 155                 160 


Arg Ala His Ala Ala Ser Asp Thr Val Gly Trp Gln Val Phe Phe Val 
                165                 170                 175     


Phe Ser Phe Phe Ile Thr Leu Pro Leu Ser Leu Ser Pro Ile Val Ile 
            180                 185                 190         


Ile Ser Val Val Ser Cys Val Val His Thr Leu Val Leu Gly Val Thr 
        195                 200                 205             


Val Ala Gln Gln Gln Gln Glu Glu Leu Lys Gly Met Gln Leu Leu Arg 
    210                 215                 220                 


Glu Ile Leu Ala Asn Val Phe Leu Tyr Leu Cys Ala Ile Ala Val Gly 
225                 230                 235                 240 


Ile Met Ser Tyr Tyr Met Ala Asp Arg Lys His Arg Lys Ala Phe Leu 
                245                 250                 255     


Glu Ala Arg Gln Ser Leu Glu Val Lys Met Asn Leu Glu Glu Gln Ser 
            260                 265                 270         


Gln Gln Gln Glu Asn Leu Met Leu Ser Ile Leu Pro Lys His Val Ala 
        275                 280                 285             


Asp Glu Met Leu Lys Asp Met Lys Lys Asp Glu Ser Gln Lys Asp Gln 
    290                 295                 300                 


Gln Gln Phe Asn Thr Met Tyr Met Tyr Arg His Glu Asn Val Ser Ile 
305                 310                 315                 320 


Leu Phe Ala Asp Ile Val Gly Phe Thr Gln Leu Ser Ser Ala Cys Ser 
                325                 330                 335     


Ala Gln Glu Leu Val Lys Leu Leu Asn Glu Leu Phe Ala Arg Phe Asp 
            340                 345                 350         


Lys Leu Ala Ala Lys Tyr His Gln Leu Arg Ile Lys Ile Leu Gly Asp 
        355                 360                 365             


Cys Tyr Tyr Cys Ile Cys Gly Leu Pro Asp Tyr Arg Glu Asp His Ala 
    370                 375                 380                 


Val Cys Ser Ile Leu Met Gly Leu Ala Met Val Glu Ala Ile Ser Tyr 
385                 390                 395                 400 


Val Arg Glu Lys Thr Lys Thr Gly Val Asp Met Arg Val Gly Val His 
                405                 410                 415     


Thr Gly Thr Val Leu Gly Gly Val Leu Gly Gln Lys Arg Trp Gln Tyr 
            420                 425                 430         


Asp Val Trp Ser Thr Asp Val Thr Val Ala Asn Lys Met Glu Ala Gly 
        435                 440                 445             


Gly Ile Pro Gly Arg Val His Ile Ser Gln Ser Thr Met Asp Cys Leu 
    450                 455                 460                 


Lys Gly Glu Phe Asp Val Glu Pro Gly Asp Gly Gly Ser Arg Cys Asp 
465                 470                 475                 480 


Tyr Leu Glu Glu Lys Gly Ile Glu Thr Tyr Leu Ile Ile Ala Ser Lys 
                485                 490                 495     


Pro Glu Val Lys Lys Thr Ala Thr Gln Asn Gly Leu Asn Gly Ser Ala 
            500                 505                 510         


Leu Pro Asn Gly Ala Pro Ala Ser Ser Lys Ser Ser Ser Pro Ala Leu 
        515                 520                 525             


Ile Glu Thr Lys Glu Pro Asn Gly Ser Ala His Ser Ser Gly Ser Thr 
    530                 535                 540                 


Ser Glu Lys Pro Glu Glu Gln Asp Ala Gln Ala Asp Asn Pro Ser Phe 
545                 550                 555                 560 


Pro Asn Pro Arg Arg Arg Leu Arg Leu Gln Asp Leu Ala Asp Arg Val 
                565                 570                 575     


Val Asp Ala Ser Glu Asp Glu His Glu Leu Asn Gln Leu Leu Asn Glu 
            580                 585                 590         


Ala Leu Leu Glu Arg Glu Ser Ala Gln Val Val Lys Lys Arg Asn Thr 
        595                 600                 605             


Phe Leu Leu Ser Met Arg Phe Met Asp Pro Glu Met Glu Thr Arg Tyr 
    610                 615                 620                 


Ser Val Glu Lys Glu Lys Gln Ser Gly Ala Ala Phe Ser Cys Ser Cys 
625                 630                 635                 640 


Val Val Leu Leu Cys Thr Ala Leu Val Glu Ile Leu Ile Asp Pro Trp 
                645                 650                 655     


Leu Met Thr Asn Tyr Val Thr Phe Met Val Gly Glu Ile Leu Leu Leu 
            660                 665                 670         


Ile Leu Thr Ile Cys Ser Leu Ala Ala Ile Phe Pro Arg Ala Phe Pro 
        675                 680                 685             


Lys Lys Leu Val Ala Phe Ser Thr Trp Ile Asp Arg Thr Arg Trp Ala 
    690                 695                 700                 


Arg Asn Thr Trp Ala Met Leu Ala Ile Phe Ile Leu Val Met Ala Asn 
705                 710                 715                 720 


Val Val Asp Met Leu Ser Cys Leu Gln Tyr Tyr Thr Gly Pro Ser Asn 
                725                 730                 735     


Ala Thr Ala Gly Met Glu Thr Glu Gly Ser Cys Leu Glu Asn Pro Lys 
            740                 745                 750         


Tyr Tyr Asn Tyr Val Ala Val Leu Ser Leu Ile Ala Thr Ile Met Leu 
        755                 760                 765             


Val Gln Val Ser His Met Val Lys Leu Thr Leu Met Leu Leu Val Ala 
    770                 775                 780                 


Gly Ala Val Ala Thr Ile Asn Leu Tyr Ala Trp Arg Pro Val Phe Asp 
785                 790                 795                 800 


Glu Tyr Asp His Lys Arg Phe Arg Glu His Asp Leu Pro Met Val Ala 
                805                 810                 815     


Leu Glu Gln Met Gln Gly Phe Asn Pro Gly Leu Asn Gly Thr Asp Arg 
            820                 825                 830         


Leu Pro Leu Val Pro Ser Lys Tyr Ser Met Thr Val Met Val Phe Leu 
        835                 840                 845             


Met Met Leu Ser Phe Tyr Tyr Phe Ser Arg His Val Glu Lys Leu Ala 
    850                 855                 860                 


Arg Thr Leu Phe Leu Trp Lys Ile Glu Val His Asp Gln Lys Glu Arg 
865                 870                 875                 880 


Val Tyr Glu Met Arg Arg Trp Asn Glu Ala Leu Val Thr Asn Met Leu 
                885                 890                 895     


Pro Glu His Val Ala Arg His Phe Leu Gly Ser Lys Lys Arg Asp Glu 
            900                 905                 910         


Glu Leu Tyr Ser Gln Thr Tyr Asp Glu Ile Gly Val Met Phe Ala Ser 
        915                 920                 925             


Leu Pro Asn Phe Ala Asp Phe Tyr Thr Glu Glu Ser Ile Asn Asn Gly 
    930                 935                 940                 


Gly Ile Glu Cys Leu Arg Phe Leu Asn Glu Ile Ile Ser Asp Phe Asp 
945                 950                 955                 960 


Ser Leu Leu Asp Asn Pro Lys Phe Arg Val Ile Thr Lys Ile Lys Thr 
                965                 970                 975     


Ile Gly Ser Thr Tyr Met Ala Ala Ser Gly Val Thr Pro Asp Val Asn 
            980                 985                 990         


Thr Asn Gly Phe Ala Ser Ser Asn Lys Glu Asp Lys Ser Glu Arg Glu 
        995                 1000                1005            


Arg Trp Gln His Leu Ala Asp Leu Ala Asp Phe Ala Leu Ala Met Lys 
    1010                1015                1020                


Asp Thr Leu Thr Asn Ile Asn Asn Gln Ser Phe Asn Asn Phe Met Leu 
1025                1030                1035                1040


Arg Ile Gly Met Asn Lys Gly Gly Val Leu Ala Gly Val Ile Gly Ala 
                1045                1050                1055    


Arg Lys Pro His Tyr Asp Ile Trp Gly Asn Thr Val Asn Val Ala Ser 
            1060                1065                1070        


Arg Met Glu Ser Thr Gly Val Met Gly Asn Ile Gln Val Val Glu Glu 
        1075                1080                1085            


Thr Gln Val Ile Leu Arg Glu Tyr Gly Phe Arg Phe Val Arg Arg Gly 
    1090                1095                1100                


Pro Ile Phe Val Lys Gly Lys Gly Glu Leu Leu Thr Phe Phe Leu Lys 
1105                1110                1115                1120


Gly Arg Asp Lys Leu Ala Thr Phe Pro Asn Gly Pro Ser Val Thr Leu 
                1125                1130                1135    


Pro His Gln Val Val Asp Asn Ser 
            1140                

<210>  212

<211>  744
<212>  DNA
<213>  homo sapiens

<220>
<223>  BDNF

<400>  212
atgaccatcc ttttccttac tatggttatt tcatactttg gttgcatgaa ggctgccccc     60
atgaaagaag caaacatccg aggacaaggt ggcttggcct acccaggtgt gcggacccat    120
gggactctgg agagcgtgaa tgggcccaag gcaggttcaa gaggcttgac atcattggct    180
gacactttcg aacacatgat agaagagctg ttggatgagg accagaaagt tcggcccaat    240
gaagaaaaca ataaggacgc agacttgtac acgtccaggg tgatgctcag tagtcaagtg    300
cctttggagc ctcctcttct ctttctgctg gaggaataca aaaattacct agatgctgca    360
aacatgtcca tgagggtccg gcgccactct gaccctgccc gccgagggga gctgagcgtg    420
tgtgacagta ttagtgagtg ggtaacggcg gcagacaaaa agactgcagt ggacatgtcg    480
ggcgggacgg tcacagtcct tgaaaaggtc cctgtatcaa aaggccaact gaagcaatac    540
ttctacgaga ccaagtgcaa tcccatgggt tacacaaaag aaggctgcag gggcatagac    600
aaaaggcatt ggaactccca gtgccgaact acccagtcgt acgtgcgggc ccttaccatg    660
gatagcaaaa agagaattgg ctggcgattc ataaggatag acacttcttg tgtatgtaca    720
ttgaccatta aaaggggaag atag                                           744


<210>  213

<211>  247
<212>  PRT
<213>  homo sapiens

<220>
<223>  BDNF

<400>  213
Met Thr Ile Leu Phe Leu Thr Met Val Ile Ser Tyr Phe Gly Cys Met 
1               5                   10                  15      


Lys Ala Ala Pro Met Lys Glu Ala Asn Ile Arg Gly Gln Gly Gly Leu 
            20                  25                  30          


Ala Tyr Pro Gly Val Arg Thr His Gly Thr Leu Glu Ser Val Asn Gly 
        35                  40                  45              


Pro Lys Ala Gly Ser Arg Gly Leu Thr Ser Leu Ala Asp Thr Phe Glu 
    50                  55                  60                  


His Val Ile Glu Glu Leu Leu Asp Glu Asp Gln Lys Val Arg Pro Asn 
65                  70                  75                  80  


Glu Glu Asn Asn Lys Asp Ala Asp Leu Tyr Thr Ser Arg Val Met Leu 
                85                  90                  95      


Ser Ser Gln Val Pro Leu Glu Pro Pro Leu Leu Phe Leu Leu Glu Glu 
            100                 105                 110         


Tyr Lys Asn Tyr Leu Asp Ala Ala Asn Met Ser Met Arg Val Arg Arg 
        115                 120                 125             


His Ser Asp Pro Ala Arg Arg Gly Glu Leu Ser Val Cys Asp Ser Ile 
    130                 135                 140                 


Ser Glu Trp Val Thr Ala Ala Asp Lys Lys Thr Ala Val Asp Met Ser 
145                 150                 155                 160 


Gly Gly Thr Val Thr Val Leu Glu Lys Val Pro Val Ser Lys Gly Gln 
                165                 170                 175     


Leu Lys Gln Tyr Phe Tyr Glu Thr Lys Cys Asn Pro Met Gly Tyr Thr 
            180                 185                 190         


Lys Glu Gly Cys Arg Gly Ile Asp Lys Arg His Trp Asn Ser Gln Cys 
        195                 200                 205             


Arg Thr Thr Gln Ser Tyr Val Arg Ala Leu Thr Met Asp Ser Lys Lys 
    210                 215                 220                 


Arg Ile Gly Trp Arg Phe Ile Arg Ile Asp Thr Ser Cys Val Cys Thr 
225                 230                 235                 240 


Leu Thr Ile Lys Arg Gly Arg 
                245         


<210>  214

<211>  1512
<212>  DNA
<213>  homo sapiens

<220>
<223>  KSR2

<400>  214
aggacttcaa cataggaact tgagggggac aaaattcagc ccataacatg cattgatgta     60
taacaaaaaa gcaaaaatgg aaccaaatgc aagtgagtct gcgattccag cgaggaggca    120
gcggcagccc agagccaaga agaagagcaa acccttgaac ctcaagatcc acagcagcgt    180
aggcagctgc gagaacatcc cctctcagca gcgctccccg ctgctgtccg agcgctccct    240
ccgctccttc tttgtgggac acgcaccttt cctgccttcc acccctcctg ttcacactga    300
ggccaacttc tctgcaaaca cactgtcagt gccacgctgg tccccgcaga tccctcgcag    360
agatcttggc aactccatca agcacaggtt ttccaccaag tactggatgt ctcagacgtg    420
cacagtctgt gggaaaggga tgctttttgg cctcaagtgt aaaaactgca agttaaagtg    480
ccacaacaaa tgcaccaaag aagccccacc ctgtcatctt ctgatcatcc accgaggaga    540
tccagcaagg ttagtccgga cagagtccgt tccgtgtgac atcaacaacc ctctacggaa    600
gccacctcgc tattcagacc tgcacatcag tcagacgctc cccaaaacca acaaaatcaa    660
caaggaccac atccctgtcc cttaccagcc agactccagc agcaacccct cctccacgac    720
gtcctccacg ccctcctcgc cagcaccccc cctccctcct agtgccacgc cgccttctcc    780
cctacaccct tccccacagt gcacacggca gcagaagaac ttcaacctgc cagcatccca    840
ctactacaaa tacaagcagc agttcatctt cccagatgtg gtgccggtgc cggagacgcc    900
gacccgggcg ccccaggtca tcctgcatcc ggtgacctcg aatccaatct tggaaggaaa    960
tccattactt caaattgaag tggagccaac gtcggagaat gaagaggtcc atgatgaggc   1020
cgaagagtca gaggatgact tcgaggagat gaacctgtcc ctcctctcgg cccggagctt   1080
cccacgcaag gccagccaga ccagcatctt ccttcaggag tgggacatcc cctttgagca   1140
gctggagatt ggcgagctca ttggaaaggg ccgctttggg caagtgtacc acggccgctg   1200
gcatggcgag gtggccatcc ggctgattga cattgagagg gacaacgagg accagctcaa   1260
ggccttcaag cgggaggtga tggcctacag gcagacacgg catgagaacg tggtgctttt   1320
catgggtgcc tgcatgagcc cgcctcacct ggccatcatc accaggccag tttgattgtc   1380
ctaaatataa cgtacaggag ttggggggcc tgagcacatg aagattccgt ccccatcatc   1440
gagtggaagc ggcttccttt tatgttcaaa aagctgaatc gctttccctt tataaagcac   1500
agctgaaaag gt                                                       1512


<210>  215

<211>  950
<212>  PRT
<213>  homo sapiens

<220>
<223>  KSR2

<400>  215
Met Asp Glu Glu Asn Met Thr Lys Ser Glu Glu Gln Gln Pro Leu Ser 
1               5                   10                  15      


Leu Gln Lys Ala Leu Gln Gln Cys Glu Leu Val Gln Asn Met Ile Asp 
            20                  25                  30          


Leu Ser Ile Ser Asn Leu Glu Gly Leu Arg Thr Lys Cys Ala Thr Ser 
        35                  40                  45              


Asn Asp Leu Thr Gln Lys Glu Ile Arg Thr Leu Glu Ser Lys Leu Val 
    50                  55                  60                  


Lys Tyr Phe Ser Arg Gln Leu Ser Cys Lys Lys Lys Val Ala Leu Gln 
65                  70                  75                  80  


Glu Arg Asn Ala Glu Leu Asp Gly Phe Pro Gln Leu Arg His Trp Phe 
                85                  90                  95      


Arg Ile Val Asp Val Arg Lys Glu Val Leu Glu Glu Ile Ser Pro Gly 
            100                 105                 110         


Gln Leu Ser Leu Glu Asp Leu Leu Glu Met Thr Asp Glu Gln Val Cys 
        115                 120                 125             


Glu Thr Val Glu Lys Tyr Gly Ala Asn Arg Glu Glu Cys Ala Arg Leu 
    130                 135                 140                 


Asn Ala Ser Leu Ser Cys Leu Arg Asn Val His Met Ser Gly Gly Asn 
145                 150                 155                 160 


Leu Ser Lys Gln Asp Trp Thr Ile Gln Trp Pro Thr Thr Glu Thr Gly 
                165                 170                 175     


Lys Glu Asn Asn Pro Val Cys Pro Pro Glu Pro Thr Pro Trp Ile Arg 
            180                 185                 190         


Thr His Leu Ser Gln Ser Pro Arg Val Pro Ser Lys Cys Val Gln His 
        195                 200                 205             


Tyr Cys His Thr Ser Pro Thr Pro Gly Ala Pro Val Tyr Thr His Val 
    210                 215                 220                 


Asp Arg Leu Thr Val Asp Ala Tyr Pro Gly Leu Cys Pro Pro Pro Pro 
225                 230                 235                 240 


Leu Glu Ser Gly His Arg Ser Leu Pro Pro Ser Pro Arg Gln Arg His 
                245                 250                 255     


Ala Val Arg Thr Pro Pro Arg Thr Pro Asn Ile Val Thr Thr Val Thr 
            260                 265                 270         


Pro Pro Gly Thr Pro Pro Met Arg Lys Lys Asn Lys Leu Lys Pro Pro 
        275                 280                 285             


Gly Thr Pro Pro Pro Ser Ser Arg Lys Leu Ile His Leu Ile Pro Gly 
    290                 295                 300                 


Phe Thr Ala Leu His Arg Ser Lys Ser His Glu Phe Gln Leu Gly His 
305                 310                 315                 320 


Arg Val Asp Glu Ala His Thr Pro Lys Ala Lys Lys Lys Ser Lys Pro 
                325                 330                 335     


Leu Asn Leu Lys Ile His Ser Ser Val Gly Ser Cys Glu Asn Ile Pro 
            340                 345                 350         


Ser Gln Gln Arg Ser Pro Leu Leu Ser Glu Arg Ser Leu Arg Ser Phe 
        355                 360                 365             


Phe Val Gly His Ala Pro Phe Leu Pro Ser Thr Pro Pro Val His Thr 
    370                 375                 380                 


Glu Ala Asn Phe Ser Ala Asn Thr Leu Ser Val Pro Arg Trp Ser Pro 
385                 390                 395                 400 


Gln Ile Pro Arg Arg Asp Leu Gly Asn Ser Ile Lys His Arg Phe Ser 
                405                 410                 415     


Thr Lys Tyr Trp Met Ser Gln Thr Cys Thr Val Cys Gly Lys Gly Met 
            420                 425                 430         


Leu Phe Gly Leu Lys Cys Lys Asn Cys Lys Leu Lys Cys His Asn Lys 
        435                 440                 445             


Cys Thr Lys Glu Ala Pro Pro Cys His Leu Leu Ile Ile His Arg Gly 
    450                 455                 460                 


Asp Pro Ala Arg Leu Val Arg Thr Glu Ser Val Pro Cys Asp Ile Asn 
465                 470                 475                 480 


Asn Pro Leu Arg Lys Pro Pro Arg Tyr Ser Asp Leu His Ile Ser Gln 
                485                 490                 495     


Thr Leu Pro Lys Thr Asn Lys Ile Asn Lys Asp His Ile Pro Val Pro 
            500                 505                 510         


Tyr Gln Pro Asp Ser Ser Ser Asn Pro Ser Ser Thr Thr Ser Ser Thr 
        515                 520                 525             


Pro Ser Ser Pro Ala Pro Pro Leu Pro Pro Ser Ala Thr Pro Pro Ser 
    530                 535                 540                 


Pro Leu His Pro Ser Pro Gln Cys Thr Arg Gln Gln Lys Asn Phe Asn 
545                 550                 555                 560 


Leu Pro Ala Ser His Tyr Tyr Lys Tyr Lys Gln Gln Phe Ile Phe Pro 
                565                 570                 575     


Asp Val Val Pro Val Pro Glu Thr Pro Thr Arg Ala Pro Gln Val Ile 
            580                 585                 590         


Leu His Pro Val Thr Ser Asn Pro Ile Leu Glu Gly Asn Pro Leu Leu 
        595                 600                 605             


Gln Ile Glu Val Glu Pro Thr Ser Glu Asn Glu Glu Val His Asp Glu 
    610                 615                 620                 


Ala Glu Glu Ser Glu Asp Asp Phe Glu Glu Met Asn Leu Ser Leu Leu 
625                 630                 635                 640 


Ser Ala Arg Ser Phe Pro Arg Lys Ala Ser Gln Thr Ser Ile Phe Leu 
                645                 650                 655     


Gln Glu Trp Asp Ile Pro Phe Glu Gln Leu Glu Ile Gly Glu Leu Ile 
            660                 665                 670         


Gly Lys Gly Arg Phe Gly Gln Val Tyr His Gly Arg Trp His Gly Glu 
        675                 680                 685             


Val Ala Ile Arg Leu Ile Asp Ile Glu Arg Asp Asn Glu Asp Gln Leu 
    690                 695                 700                 


Lys Ala Phe Lys Arg Glu Val Met Ala Tyr Arg Gln Thr Arg His Glu 
705                 710                 715                 720 


Asn Val Val Leu Phe Met Gly Ala Cys Met Ser Pro Pro His Leu Ala 
                725                 730                 735     


Ile Ile Thr Ser Leu Cys Lys Gly Arg Thr Leu Tyr Ser Val Val Arg 
            740                 745                 750         


Asp Ala Lys Ile Val Leu Asp Val Asn Lys Thr Arg Gln Ile Ala Gln 
        755                 760                 765             


Glu Ile Val Lys Gly Met Gly Tyr Leu His Ala Lys Gly Ile Leu His 
    770                 775                 780                 


Lys Asp Leu Lys Ser Lys Asn Val Phe Tyr Asp Asn Gly Lys Val Val 
785                 790                 795                 800 


Ile Thr Asp Phe Gly Leu Phe Ser Ile Ser Gly Val Leu Gln Ala Gly 
                805                 810                 815     


Arg Arg Glu Asp Lys Leu Arg Ile Gln Asn Gly Trp Leu Cys His Leu 
            820                 825                 830         


Ala Pro Glu Ile Ile Arg Gln Leu Ser Pro Asp Thr Glu Glu Asp Lys 
        835                 840                 845             


Leu Pro Phe Ser Lys His Ser Asp Val Phe Ala Leu Gly Thr Ile Trp 
    850                 855                 860                 


Tyr Glu Leu His Ala Arg Glu Trp Pro Phe Lys Thr Gln Pro Ala Glu 
865                 870                 875                 880 


Ala Ile Ile Trp Gln Met Gly Thr Gly Met Lys Pro Asn Leu Ser Gln 
                885                 890                 895     


Ile Gly Met Gly Lys Glu Ile Ser Asp Ile Leu Leu Phe Cys Trp Ala 
            900                 905                 910         


Phe Glu Gln Glu Glu Arg Pro Thr Phe Thr Lys Leu Met Asp Met Leu 
        915                 920                 925             


Glu Lys Leu Pro Lys Arg Asn Arg Arg Leu Ser His Pro Gly His Phe 
    930                 935                 940                 


Trp Lys Ser Ala Glu Leu 
945                 950 


<210>  216

<211>  501
<212>  DNA
<213>  homo sapiens

<220>
<223>  LEP

<400>  216
atgcattggg gaaccctgtg cggattcttg tggctttggc cctatctttt ctatgtccaa     60
gctgtgccca tccaaaaagt ccaagatgac accaaaaccc tcatcaagac aattgtcacc    120
aggatcaatg acatttcaca cacgtcagtc tcctccaaac agaaagtcac cggtttggac    180
ttcattcctg ggctccaccc catcctgacc ttatccaaga tggaccagac actggcagtc    240
taccaacaga tcctcaccag tatgccttcc agaaacgtga tccaaatatc caacgacctg    300
gagaacctcc gggatcttct tcacgtgctg gccttctcta agagctgcca cttgccctgg    360
gccagtggcc tggagacctt ggacagcctg gggggtgtcc tggaagcttc aggctactcc    420
acagaggtgg tggccctgag caggctgcag gggtctctgc aggacatgct gtggcagctg    480
gacctcagcc ctgggtgctg a                                              501


<210>  217

<211>  167
<212>  PRT
<213>  homo sapiens

<220>
<223>  LEP

<400>  217
Met His Trp Gly Thr Leu Cys Gly Phe Leu Trp Leu Trp Pro Tyr Leu 
1               5                   10                  15      


Phe Tyr Val Gln Ala Val Pro Ile Gln Lys Val Gln Asp Asp Thr Lys 
            20                  25                  30          


Thr Leu Ile Lys Thr Ile Val Thr Arg Ile Asn Asp Ile Ser His Thr 
        35                  40                  45              


Gln Ser Val Ser Ser Lys Gln Lys Val Thr Gly Leu Asp Phe Ile Pro 
    50                  55                  60                  


Gly Leu His Pro Ile Leu Thr Leu Ser Lys Met Asp Gln Thr Leu Ala 
65                  70                  75                  80  


Val Tyr Gln Gln Ile Leu Thr Ser Met Pro Ser Arg Asn Val Ile Gln 
                85                  90                  95      


Ile Ser Asn Asp Leu Glu Asn Leu Arg Asp Leu Leu His Val Leu Ala 
            100                 105                 110         


Phe Ser Lys Ser Cys His Leu Pro Trp Ala Ser Gly Leu Glu Thr Leu 
        115                 120                 125             


Asp Ser Leu Gly Gly Val Leu Glu Ala Ser Gly Tyr Ser Thr Glu Val 
    130                 135                 140                 


Val Ala Leu Ser Arg Leu Gln Gly Ser Leu Gln Asp Met Leu Trp Gln 
145                 150                 155                 160 


Leu Asp Leu Ser Pro Gly Cys 
                165         


<210>  218

<211>  49
<212>  DNA
<213>  homo sapiens

<220>
<223>  TRAC TALEN target s

<400>  218
ttcctcctac tcaccatcag cctcctggtt atggtacagg taagagcaa                 49


<210>  219

<211>  47
<212>  DNA
<213>  homo sapiens

<220>
<223>  B2M TALEN target

<400>  219
tccgtggcct tagctgtgct cgcgctactc tctctttctg gcctgga                   47


<210>  220

<211>  2550
<212>  DNA
<213>  artificial

<220>
<223>  CD22CAR repair template

<400>  220
ggttttccca gtcacgacgt tgtaaaacga cggccagtga attcgagctc ggtacctcgc     60
gaatgcatct agatgcggcc gcaagtagcc ctgcatttca ggtttccttg agtggcaggc    120
caggcctggc cgtgaacgtt cactgaaatc atggcctctt ggccaagatt gatagcttgt    180
gcctgtccct gagtcccagt ccatcacgag cagctggttt ctaagatgct atttcccgta    240
taaagcatga gaccgtgact tgccagcccc acagagcccc gcccttgtcc atcactggca    300
tctggactcc agcctgggtt ggggcaaaga gggaaatgag atcatgtcct aaccctgatc    360
ctcttgtccc acagatatcc agtccggtga gggcagagga agtcttctaa catgcggtga    420
cgtggaggag aatccgggcc ccggatccgc tctgcccgtc accgctctgc tgctgccact    480
ggcactgctg ctgcacgctg ctaggcccca ggtgcagctg cagcagagcg gccctggcct    540
ggtgaagcca agccagacac tgtccctgac ctgcgccatc agcggcgatt ccgtgagctc    600
caactccgcc gcctggaatt ggatcaggca gtccccttct cggggcctgg agtggctggg    660
aaggacatac tatcggtcta agtggtacaa cgattatgcc gtgtctgtga agagcagaat    720
cacaatcaac cctgacacct ccaagaatca gttctctctg cagctgaata gcgtgacacc    780
agaggacacc gccgtgtact attgcgccag ggaggtgacc ggcgacctgg aggatgcctt    840
tgacatctgg ggccagggca caatggtgac cgtgtctagc ggaggcggag gctccggagg    900
cggaggatct ggcggaggcg gaagcgatat ccagatgaca cagtccccat cctctctgag    960
cgcctccgtg ggcgacagag tgacaatcac ctgtagggcc tcccagacca tctggtctta   1020
cctgaactgg tatcagcaga ggcccggcaa ggcccctaat ctgctgatct acgcagcaag   1080
ctccctgcag agcggagtgc catccagatt ctctggcagg ggctccggca cagacttcac   1140
cctgaccatc tctagcctcc aggccgagga cttcgccacc tactattgcc agcagtctta   1200
tagcatcccc cagacatttg gccagggcac caagctggag atcaaggctc ccaccacaac   1260
ccccgctcca aggcccccta cccccgcacc aactattgcc tcccagccac tctcactgcg   1320
gcctgaggcc tgtcggcccg ctgctggagg cgcagtgcat acaaggggcc tcgatttcgc   1380
ctgcgatatt tacatctggg cacccctcgc cggcacctgc ggggtgcttc tcctctccct   1440
ggtgattacc ctgtattgca gacggggccg gaagaagctc ctctacattt ttaagcagcc   1500
tttcatgcgg ccagtgcaga caacccaaga ggaggatggg tgttcctgca gattccctga   1560
ggaagaggaa ggcgggtgcg agctgagagt gaagttctcc aggagcgcag atgcccccgc   1620
ctatcaacag ggccagaacc agctctacaa cgagcttaac ctcgggaggc gcgaagaata   1680
cgacgtgttg gataagagaa gggggcggga ccccgagatg ggaggaaagc cccggaggaa   1740
gaaccctcag gagggcctgt acaacgagct gcagaaggat aagatggccg aggcctactc   1800
agagatcggg atgaaggggg agcggcgccg cgggaagggg cacgatgggc tctaccaggg   1860
gctgagcaca gccacaaagg acacatacga cgccttgcac atgcaggccc ttccaccccg   1920
gtgaagatac attgatgagt ttggacaaac cacaactaga atgcagtgaa aaaaatgctt   1980
tatttgtgaa atttgtgatg ctattgcttt atttgtaacc attataagct gcaataaaca   2040
agttaacaac aacaattgca ttcattttat gtttcaggtt cagggggagg tgtgggaggt   2100
tttttaaagc aagtaaaacc tctacaaatg tggtacggaa ttcagtcaat atgttcaccg   2160
tgtaccagct gagagactct aaatccagtg acaagtctgt ctgcctattc accgattttg   2220
attctcaaac aaatgtgtca caaagtaagg attctgatgt gtatatcaca gacaaaactg   2280
tgctagacat gaggtctatg gacttcaaga gcaacagtgc tgtggcctgg agcaacaaat   2340
ctgactttgc atgtgcaaac gccttcaaca acagcattat tccagaagac accttcttcc   2400
ccagcccagg taagggcagc tttggtgcct tcgcaggctg tttccttgct tcaggaactc   2460
gagtatcgga tcccgggccc gtcgactgca gaggcctgca tgcaagcttg gcgtaatcat   2520
ggtcatagct gtttcctgtg tgaaattgtt                                    2550


<210>  221

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  M13F

<400>  221
cccagtcacg acgttgtaaa acg                                             23


<210>  222

<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  M13R

<400>  222
cctgtgtgaa attgttatcc gct                                             23


<210>  223

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  B2M cross_L

<400>  223
cattcctgaa gctgacagca ttcggg                                          26


<210>  224

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  B2M cross_R

<400>  224
gggtaggaga gactcacgct ggatag                                          26


<210>  225

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  B2M up_L

<400>  225
cgtgacttcc cttctccaag ttctcc                                          26


<210>  226

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  B2M up_R

<400>  226
acgcttatcg acgccctaaa ctttgt                                          26


<210>  227

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  TRAC cross_L

<400>  227
gcatttcagg tttccttgag tggcag                                          26


<210>  228

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  TRAC cross_R

<400>  228
tggcaagtca cggtctcatg ctttat                                          26


<210>  229

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  TRAC up_L

<400>  229
cttgtccatc actggcatct ggactc                                          26


<210>  230

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  TRAC up_R

<400>  230
atcggtgaat aggcagacag acttgt                                          26


<210>  231

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  CD22CAR_F

<400>  231
aagatgtaca gtttgctttg ctgggc                                          26


<210>  232

<211>  26
<212>  DNA
<213>  artificial

<220>
<223>  CD22CAR_R

<400>  232
acgtcaccgc atgttagaag acttcc                                          26


<210>  233

<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  B2M_NGS_L

<400>  233
ctacacgacg ctcttccgat ctgtccctct ctctaacctg gc                        42


<210>  234

<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  B2M_NGS_R

<400>  234
gtgactggag ttcagacgtg tgctcttccg atctgaaggg aagtcacgga gcga           54


<210>  235

<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  TRAC_NGS_L

<400>  235
gtcgactagg gataacaggg taattatcca gaaccctgac cctgccgtgt acca           54


<210>  236

<211>  54
<212>  DNA
<213>  artificial

<220>
<223>  TRAC_NGS_R

<400>  236
aaactgtatt ataagtaaat gcattggatt tagagtctct cagctggtac acgg           54


<210>  237

<211>  203
<212>  DNA
<213>  artificial

<220>
<223>  HSC ssODN1

<400>  237
acttcatcca cgttcacctt gccccacagg gcagtaacgg cagacttctc ctccctagga     60
gtcagatgca ccatggtgtc ggcttgaggt tgacagtgaa cacagttgtg tcagaagcaa    120
atgtaagcaa tagatggctc tgccctgact tttatgccca gccctggctc ctgccctccc    180
tgctcctggg agtagattgg cca                                            203


<210>  238

<211>  203
<212>  DNA
<213>  artificial

<220>
<223>  HSC ssODN2

<400>  238
gataccaacc tgcccagggc ctcaccacca acttcatcca cgttcacctt gccccacagg     60
gcagtaacgg cagacttctc ctccctagga gtcagatgca ccatggtgtc ggcttgaggt    120
tgacagtgaa cacagttgtg tcagaagcaa atgtaagcaa tagatggctc tgccctgact    180
tttatgccca gccctggctc ctg                                            203


<210>  239

<211>  50
<212>  DNA
<213>  homo sapiens

<220>
<223>  HBB Target

<400>  239
ttgcttacat ttgcttctga cacaactgtg ttcactagca acctcaaaca                50


<210>  240

<211>  170
<212>  DNA
<213>  artificial

<220>
<223>  TRAC ssODN

<400>  240
cctgggttgg ggcaaagagg gaaatgagat catgtcctaa ccctgatcct cttgtcccac     60
agatatccag aaccctaggt gaaagcttag actagtgacc ctgccgtgta ccagctgaga    120
gactctaaat ccagtgacaa gtctgtctgc ctattcaccg attttgattc               170


<210>  241

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  HBB TALEN LEFT

<400>  241
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccccagc aggtggtggc catcgccagc    480
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcaa tattggtggc    900
aagcaggcgc tggagacggt gcaggcgctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc cacgatggcg gcaagcaggc gctggagacg   1020
gtccagcggc tgttgccggt gctgtgccag gcccacggct tgaccccgga gcaggtggtg   1080
gccatcgcca gcaatattgg tggcaagcag gcgctggaga cggtgcaggc gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaatggc   1200
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaatg gcggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccccagc aggtggtggc catcgccagc   1500
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc   1800
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccggagcag gtggtggcca tcgccagcca cgatggcggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  242

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  HBB TALEN LEFT PRT

<400>  242
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Glu Gln Val Val Ala Ile Ala Ser His Asp Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 



<210>  243

<211>  2781
<212>  DNA
<213>  artificial

<220>
<223>  HBB TALEN RIGHT

<400>  243
atgggcgatc ctaaaaagaa acgtaaggtc atcgatatcg ccgatctacg cacgctcggc     60
tacagccagc agcaacagga gaagatcaaa ccgaaggttc gttcgacagt ggcgcagcac    120
cacgaggcac tggtcggcca cgggtttaca cacgcgcaca tcgttgcgtt aagccaacac    180
ccggcagcgt tagggaccgt cgctgtcaag tatcaggaca tgatcgcagc gttgccagag    240
gcgacacacg aagcgatcgt tggcgtcggc aaacagtggt ccggcgcacg cgctctggag    300
gccttgctca cggtggcggg agagttgaga ggtccaccgt tacagttgga cacaggccaa    360
cttctcaaga ttgcaaaacg tggcggcgtg accgcagtgg aggcagtgca tgcatggcgc    420
aatgcactga cgggtgcccc gctcaacttg accccccagc aggtggtggc catcgccagc    480
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag    540
gcccacggct tgacccccca gcaggtggtg gccatcgcca gcaatggcgg tggcaagcag    600
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc    660
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag    720
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cccagcaggt ggtggccatc    780
gccagcaatg gcggtggcaa gcaggcgctg gagacggtcc agcggctgtt gccggtgctg    840
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc    900
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg    960
accccggagc aggtggtggc catcgccagc aatattggtg gcaagcaggc gctggagacg   1020
gtgcaggcgc tgttgccggt gctgtgccag gcccacggct tgacccccca gcaggtggtg   1080
gccatcgcca gcaataatgg tggcaagcag gcgctggaga cggtccagcg gctgttgccg   1140
gtgctgtgcc aggcccacgg cttgaccccc cagcaggtgg tggccatcgc cagcaataat   1200
ggtggcaagc aggcgctgga gacggtccag cggctgttgc cggtgctgtg ccaggcccac   1260
ggcttgaccc cccagcaggt ggtggccatc gccagcaatg gcggtggcaa gcaggcgctg   1320
gagacggtcc agcggctgtt gccggtgctg tgccaggccc acggcttgac cccccagcag   1380
gtggtggcca tcgccagcaa tggcggtggc aagcaggcgc tggagacggt ccagcggctg   1440
ttgccggtgc tgtgccaggc ccacggcttg accccccagc aggtggtggc catcgccagc   1500
aataatggtg gcaagcaggc gctggagacg gtccagcggc tgttgccggt gctgtgccag   1560
gcccacggct tgaccccgga gcaggtggtg gccatcgcca gccacgatgg cggcaagcag   1620
gcgctggaga cggtccagcg gctgttgccg gtgctgtgcc aggcccacgg cttgaccccc   1680
cagcaggtgg tggccatcgc cagcaatggc ggtggcaagc aggcgctgga gacggtccag   1740
cggctgttgc cggtgctgtg ccaggcccac ggcttgaccc cggagcaggt ggtggccatc   1800
gccagcaata ttggtggcaa gcaggcgctg gagacggtgc aggcgctgtt gccggtgctg   1860
tgccaggccc acggcttgac cccccagcag gtggtggcca tcgccagcaa taatggtggc   1920
aagcaggcgc tggagacggt ccagcggctg ttgccggtgc tgtgccaggc ccacggcttg   1980
acccctcagc aggtggtggc catcgccagc aatggcggcg gcaggccggc gctggagagc   2040
attgttgccc agttatctcg ccctgatccg gcgttggccg cgttgaccaa cgaccacctc   2100
gtcgccttgg cctgcctcgg cgggcgtcct gcgctggatg cagtgaaaaa gggattgggg   2160
gatcctatca gccgttccca gctggtgaag tccgagctgg aggagaagaa atccgagttg   2220
aggcacaagc tgaagtacgt gccccacgag tacatcgagc tgatcgagat cgcccggaac   2280
agcacccagg accgtatcct ggagatgaag gtgatggagt tcttcatgaa ggtgtacggc   2340
tacaggggca agcacctggg cggctccagg aagcccgacg gcgccatcta caccgtgggc   2400
tcccccatcg actacggcgt gatcgtggac accaaggcct actccggcgg ctacaacctg   2460
cccatcggcc aggccgacga aatgcagagg tacgtggagg agaaccagac caggaacaag   2520
cacatcaacc ccaacgagtg gtggaaggtg tacccctcca gcgtgaccga gttcaagttc   2580
ctgttcgtgt ccggccactt caagggcaac tacaaggccc agctgaccag gctgaaccac   2640
atcaccaact gcaacggcgc cgtgctgtcc gtggaggagc tcctgatcgg cggcgagatg   2700
atcaaggccg gcaccctgac cctggaggag gtgaggagga agttcaacaa cggcgagatc   2760
aacttcgcgg ccgactgata a                                             2781


<210>  244

<211>  925
<212>  PRT
<213>  artificial

<220>
<223>  HBB TALEN RIGHT PRT

<400>  244
Met Gly Asp Pro Lys Lys Lys Arg Lys Val Ile Asp Ile Ala Asp Leu 
1               5                   10                  15      


Arg Thr Leu Gly Tyr Ser Gln Gln Gln Gln Glu Lys Ile Lys Pro Lys 
            20                  25                  30          


Val Arg Ser Thr Val Ala Gln His His Glu Ala Leu Val Gly His Gly 
        35                  40                  45              


Phe Thr His Ala His Ile Val Ala Leu Ser Gln His Pro Ala Ala Leu 
    50                  55                  60                  


Gly Thr Val Ala Val Lys Tyr Gln Asp Met Ile Ala Ala Leu Pro Glu 
65                  70                  75                  80  


Ala Thr His Glu Ala Ile Val Gly Val Gly Lys Gln Trp Ser Gly Ala 
                85                  90                  95      


Arg Ala Leu Glu Ala Leu Leu Thr Val Ala Gly Glu Leu Arg Gly Pro 
            100                 105                 110         


Pro Leu Gln Leu Asp Thr Gly Gln Leu Leu Lys Ile Ala Lys Arg Gly 
        115                 120                 125             


Gly Val Thr Ala Val Glu Ala Val His Ala Trp Arg Asn Ala Leu Thr 
    130                 135                 140                 


Gly Ala Pro Leu Asn Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
145                 150                 155                 160 


Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
                165                 170                 175     


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
            180                 185                 190         


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
        195                 200                 205             


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
    210                 215                 220                 


Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
225                 230                 235                 240 


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln 
                245                 250                 255     


Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr 
            260                 265                 270         


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
        275                 280                 285             


Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu 
    290                 295                 300                 


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
305                 310                 315                 320 


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
                325                 330                 335     


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
            340                 345                 350         


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
        355                 360                 365             


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
    370                 375                 380                 


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn 
385                 390                 395                 400 


Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu 
                405                 410                 415     


Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser 
            420                 425                 430         


Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro 
        435                 440                 445             


Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile 
    450                 455                 460                 


Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu Glu Thr Val Gln Arg Leu 
465                 470                 475                 480 


Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Gln Gln Val Val 
                485                 490                 495     


Ala Ile Ala Ser Asn Asn Gly Gly Lys Gln Ala Leu Glu Thr Val Gln 
            500                 505                 510         


Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro Glu Gln 
        515                 520                 525             


Val Val Ala Ile Ala Ser His Asp Gly Gly Lys Gln Ala Leu Glu Thr 
    530                 535                 540                 


Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu Thr Pro 
545                 550                 555                 560 


Gln Gln Val Val Ala Ile Ala Ser Asn Gly Gly Gly Lys Gln Ala Leu 
                565                 570                 575     


Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln Ala His Gly Leu 
            580                 585                 590         


Thr Pro Glu Gln Val Val Ala Ile Ala Ser Asn Ile Gly Gly Lys Gln 
        595                 600                 605             


Ala Leu Glu Thr Val Gln Ala Leu Leu Pro Val Leu Cys Gln Ala His 
    610                 615                 620                 


Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Asn Gly Gly 
625                 630                 635                 640 


Lys Gln Ala Leu Glu Thr Val Gln Arg Leu Leu Pro Val Leu Cys Gln 
                645                 650                 655     


Ala His Gly Leu Thr Pro Gln Gln Val Val Ala Ile Ala Ser Asn Gly 
            660                 665                 670         


Gly Gly Arg Pro Ala Leu Glu Ser Ile Val Ala Gln Leu Ser Arg Pro 
        675                 680                 685             


Asp Pro Ala Leu Ala Ala Leu Thr Asn Asp His Leu Val Ala Leu Ala 
    690                 695                 700                 


Cys Leu Gly Gly Arg Pro Ala Leu Asp Ala Val Lys Lys Gly Leu Gly 
705                 710                 715                 720 


Asp Pro Ile Ser Arg Ser Gln Leu Val Lys Ser Glu Leu Glu Glu Lys 
                725                 730                 735     


Lys Ser Glu Leu Arg His Lys Leu Lys Tyr Val Pro His Glu Tyr Ile 
            740                 745                 750         


Glu Leu Ile Glu Ile Ala Arg Asn Ser Thr Gln Asp Arg Ile Leu Glu 
        755                 760                 765             


Met Lys Val Met Glu Phe Phe Met Lys Val Tyr Gly Tyr Arg Gly Lys 
    770                 775                 780                 


His Leu Gly Gly Ser Arg Lys Pro Asp Gly Ala Ile Tyr Thr Val Gly 
785                 790                 795                 800 


Ser Pro Ile Asp Tyr Gly Val Ile Val Asp Thr Lys Ala Tyr Ser Gly 
                805                 810                 815     


Gly Tyr Asn Leu Pro Ile Gly Gln Ala Asp Glu Met Gln Arg Tyr Val 
            820                 825                 830         


Glu Glu Asn Gln Thr Arg Asn Lys His Ile Asn Pro Asn Glu Trp Trp 
        835                 840                 845             


Lys Val Tyr Pro Ser Ser Val Thr Glu Phe Lys Phe Leu Phe Val Ser 
    850                 855                 860                 


Gly His Phe Lys Gly Asn Tyr Lys Ala Gln Leu Thr Arg Leu Asn His 
865                 870                 875                 880 


Ile Thr Asn Cys Asn Gly Ala Val Leu Ser Val Glu Glu Leu Leu Ile 
                885                 890                 895     


Gly Gly Glu Met Ile Lys Ala Gly Thr Leu Thr Leu Glu Glu Val Arg 
            900                 905                 910         


Arg Lys Phe Asn Asn Gly Glu Ile Asn Phe Ala Ala Asp 
        915                 920                 925 


<210>  245

<211>  1423
<212>  PRT
<213>  artificial

<220>
<223>  Cas9 protein sequence

<400>  245
Met Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile Asp 
1               5                   10                  15      


Tyr Lys Asp Asp Asp Asp Lys Met Ala Pro Lys Lys Lys Arg Lys Val 
            20                  25                  30          


Gly Ile His Gly Val Pro Ala Ala Asp Lys Lys Tyr Ser Ile Gly Leu 
        35                  40                  45              


Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr 
    50                  55                  60                  


Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His 
65                  70                  75                  80  


Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu 
                85                  90                  95      


Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr 
            100                 105                 110         


Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu 
        115                 120                 125             


Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe 
    130                 135                 140                 


Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn 
145                 150                 155                 160 


Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His 
                165                 170                 175     


Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu 
            180                 185                 190         


Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu 
        195                 200                 205             


Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe 
    210                 215                 220                 


Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile 
225                 230                 235                 240 


Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser 
                245                 250                 255     


Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys 
            260                 265                 270         


Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr 
        275                 280                 285             


Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln 
    290                 295                 300                 


Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln 
305                 310                 315                 320 


Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser 
                325                 330                 335     


Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr 
            340                 345                 350         


Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His 
        355                 360                 365             


Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu 
    370                 375                 380                 


Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly 
385                 390                 395                 400 


Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys 
                405                 410                 415     


Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu 
            420                 425                 430         


Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser 
        435                 440                 445             


Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg 
    450                 455                 460                 


Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg 
                485                 490                 495     


Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile 
            500                 505                 510         


Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln 
        515                 520                 525             


Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu 
    530                 535                 540                 


Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr 
545                 550                 555                 560 


Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro 
                565                 570                 575     


Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe 
            580                 585                 590         


Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe 
        595                 600                 605             


Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp 
    610                 615                 620                 


Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu 
                645                 650                 655     


Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu 
            660                 665                 670         


Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys 
        675                 680                 685             


Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys 
    690                 695                 700                 


Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp 
705                 710                 715                 720 


Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile 
                725                 730                 735     


His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val 
            740                 745                 750         


Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly 
        755                 760                 765             


Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp 
    770                 775                 780                 


Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile 
785                 790                 795                 800 


Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser 
                805                 810                 815     


Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser 
            820                 825                 830         


Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu 
        835                 840                 845             


Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp 
    850                 855                 860                 


Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile 
865                 870                 875                 880 


Val Pro Gln Ser Phe Leu Ala Asp Asp Ser Ile Asp Asn Lys Val Leu 
                885                 890                 895     


Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu 
            900                 905                 910         


Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala 
        915                 920                 925             


Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg 
    930                 935                 940                 


Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu 
945                 950                 955                 960 


Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser 
                965                 970                 975     


Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val 
            980                 985                 990         


Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp 
        995                 1000                1005            


Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala His 
    1010                1015                1020                


Asp Ala Tyr Leu Asn Ala Val Val Gly Thr Ala Leu Ile Lys Lys Tyr 
1025                1030                1035                1040


Pro Ala Leu Glu Ser Glu Phe Val Tyr Gly Asp Tyr Lys Val Tyr Asp 
                1045                1050                1055    


Val Arg Lys Met Ile Ala Lys Ser Glu Gln Glu Ile Gly Lys Ala Thr 
            1060                1065                1070        


Ala Lys Tyr Phe Phe Tyr Ser Asn Ile Met Asn Phe Phe Lys Thr Glu 
        1075                1080                1085            


Ile Thr Leu Ala Asn Gly Glu Ile Arg Lys Ala Pro Leu Ile Glu Thr 
    1090                1095                1100                


Asn Gly Glu Thr Gly Glu Ile Val Trp Asp Lys Gly Arg Asp Phe Ala 
1105                1110                1115                1120


Thr Val Arg Lys Val Leu Ser Met Pro Gln Val Asn Ile Val Lys Lys 
                1125                1130                1135    


Thr Glu Val Gln Thr Gly Gly Phe Ser Lys Glu Ser Ile Leu Pro Lys 
            1140                1145                1150        


Arg Asn Ser Asp Lys Leu Ile Ala Arg Lys Lys Asp Trp Asp Pro Lys 
        1155                1160                1165            


Lys Tyr Gly Gly Phe Asp Ser Pro Thr Val Ala Tyr Ser Val Leu Val 
    1170                1175                1180                


Val Ala Lys Val Glu Lys Gly Lys Ser Lys Lys Leu Lys Ser Val Lys 
1185                1190                1195                1200


Glu Leu Leu Gly Ile Thr Ile Met Glu Arg Ser Ser Phe Glu Lys Asn 
                1205                1210                1215    


Pro Ile Asp Phe Leu Glu Ala Lys Gly Tyr Lys Glu Val Lys Lys Asp 
            1220                1225                1230        


Leu Ile Ile Lys Leu Pro Lys Tyr Ser Leu Phe Glu Leu Glu Asn Gly 
        1235                1240                1245            


Arg Lys Arg Met Leu Ala Ser Ala Gly Glu Leu Gln Lys Gly Asn Glu 
    1250                1255                1260                


Leu Ala Leu Pro Ser Lys Tyr Val Asn Phe Leu Tyr Leu Ala Ser His 
1265                1270                1275                1280


Tyr Glu Lys Leu Lys Gly Ser Pro Glu Asp Asn Glu Gln Lys Gln Leu 
                1285                1290                1295    


Phe Val Glu Gln His Lys His Tyr Leu Asp Glu Ile Ile Glu Gln Ile 
            1300                1305                1310        


Ser Glu Phe Ser Lys Arg Val Ile Leu Ala Asp Ala Asn Leu Asp Lys 
        1315                1320                1325            


Val Leu Ser Ala Tyr Asn Lys His Arg Asp Lys Pro Ile Arg Glu Gln 
    1330                1335                1340                


Ala Glu Asn Ile Ile His Leu Phe Thr Leu Thr Asn Leu Gly Ala Pro 
1345                1350                1355                1360


Ala Ala Phe Lys Tyr Phe Asp Thr Thr Ile Asp Arg Lys Arg Tyr Thr 
                1365                1370                1375    


Ser Thr Lys Glu Val Leu Asp Ala Thr Leu Ile His Gln Ser Ile Thr 
            1380                1385                1390        


Gly Leu Tyr Glu Thr Arg Ile Asp Leu Ser Gln Leu Gly Gly Asp Lys 
        1395                1400                1405            


Arg Pro Ala Ala Thr Lys Lys Ala Gly Gln Ala Lys Lys Lys Lys 
    1410                1415                1420            


<210>  246

<211>  99
<212>  DNA
<213>  artificial

<220>
<223>  TRAC guideRNA sequence

<400>  246
cagggttctg gatatctgtg ttttagagct agaaatagca agttaaaata aggctagtcc     60
gttatcaact tgaaaaagtg gcaccgagtc ggtgctttt                            99





















