                               SEQUENCE LISTING

<110> BIOVELOCITA S.R.L.
 
<120> EXOSOME-ANCHORING FUSION PROTEINS AND VACCINES

<130> 33366-45725/WO

<140> PCT/EP2021/061730
<141> 2021-05-04

<150> IT 102020000009688
<151> 2020-05-04

<160> 91    

<170> PatentIn version 3.5

<210> 1
<211> 206
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(206)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 1
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys 
        195                 200                 205     


<210> 2
<211> 205
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(205)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 2
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn 
        195                 200                 205 


<210> 3
<211> 204
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(204)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 3
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys 
        195                 200                 


<210> 4
<211> 203
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(203)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 4
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe 
        195                 200             


<210> 5
<211> 202
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(202)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 5
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr 
        195                 200         


<210> 6
<211> 201
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(201)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 6
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu 
        195                 200     


<210> 7
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(200)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 7
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro 
        195                 200 


<210> 8
<211> 199
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(199)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 8
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His 
        195                 


<210> 9
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(198)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 9
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu 
        195             


<210> 10
<211> 197
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(197)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 10
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu 
        195         


<210> 11
<211> 196
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(196)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 11
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg 
        195     


<210> 12
<211> 195
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(195)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 12
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala 
        195 


<210> 13
<211> 194
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(194)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 13
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val 
        


<210> 14
<211> 193
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(193)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 14
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His 
    


<210> 15
<211> 192
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(192)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 15
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


<210> 16
<211> 191
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(191)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 16
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe 
            180                 185                 190     


<210> 17
<211> 190
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(190)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 17
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala 
            180                 185                 190 


<210> 18
<211> 189
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(189)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 18
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu 
            180                 185                 


<210> 19
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(188)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 19
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg 
            180                 185             


<210> 20
<211> 187
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(187)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 20
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser 
            180                 185         


<210> 21
<211> 186
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(186)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 21
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp 
            180                 185     


<210> 22
<211> 185
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(185)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 22
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe 
            180                 185 


<210> 23
<211> 184
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(184)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 23
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg 
            180                 


<210> 24
<211> 183
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(183)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 24
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp 
            180             


<210> 25
<211> 182
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(182)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 25
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu 
            180         


<210> 26
<211> 181
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(181)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 26
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu 
            180     


<210> 27
<211> 180
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(180)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 27
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val 
            180 


<210> 28
<211> 179
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(179)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 28
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu 
            


<210> 29
<211> 178
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(178)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 29
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg 
        


<210> 30
<211> 177
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(177)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 30
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly 
    


<210> 31
<211> 621
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(621)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 31
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgctg a                                                621


<210> 32
<211> 531
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(531)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 32
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg g               531


<210> 33
<211> 158
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Met His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg Pro 
1               5                   10                  15      


Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His Asp 
            20                  25                  30          


Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg Glu 
        35                  40                  45              


Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp Gly 
    50                  55                  60                  


Ser Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys Ile 
65                  70                  75                  80  


Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu Glu 
                85                  90                  95      


Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile Asn 
            100                 105                 110         


Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp Lys 
        115                 120                 125             


Lys Gln Arg Phe His Asn Ile Arg Val Arg Trp Thr Gly Arg Cys Met 
    130                 135                 140                 


Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
145                 150                 155             


<210> 34
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
atgcaccaaa agagaactgc aatgtttcag gacccacagg agcgacccag aaagttacca       60

cagttatgca cagagctgca aacaactata catgatataa tattagaatg tgtgtactgc      120

aagcaacagt tactgcgacg tgaggtatat gactttgctt ttcgggattt atgcatagta      180

tatagagatg ggaatccata tgctgtatgt gataaatgtt taaagtttta ttctaaaatt      240

agtgagtata gacattattg ttatagtttg tatggaacaa cattagaaca gcaatacaac      300

aaaccgttgt gtgatttgtt aattaggtgt attaactgtc aaaagccact gtgtcctgaa      360

gaaaagcaaa gacatctgga caaaaagcaa agattccata atataagggt gcggtggacc      420

ggtcgatgta tgtcttgttg cagatcatca agaacacgta gagaaaccca gctgtaa         477


<210> 35
<211> 477
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 35
atgcaccaga agcgcaccgc catgttccag gacccccagg agcgcccccg caagctgccc       60

cagctgtgca ccgagctgca gaccaccatc cacgacatca tcctggagtg cgtgtactgc      120

aagcagcagc tgctgcgccg cgaggtgtac gacttcgcct tccgcgacct gtgcatcgtg      180

taccgcgacg gcagccccta cgccgtgtgc gacaagtgcc tgaagttcta ctccaagatc      240

agcgagtacc gccactactg ctacagcctg tacggcacca ccctggagca gcagtacaac      300

aagcccctgt gcgacctgct gatccgctgc atcaactgcc agaagcccct gtgccccgag      360

gagaagcagc gccacctgga caagaagcag cgcttccaca acatccgggt gcggtggacc      420

gggcgctgca tgagctgctg ccgcagcagc cgcacccgcc gcgagaccca gctgtaa         477


<210> 36
<211> 98
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 36
Met His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu Gln 
1               5                   10                  15      


Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser Ser 
            20                  25                  30          


Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro Asp 
        35                  40                  45              


Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser Thr 
    50                  55                  60                  


Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu Glu 
65                  70                  75                  80  


Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser Gln 
                85                  90                  95      


Lys Pro 
        


<210> 37
<211> 297
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 37
atgcatggag atacacctac attgcatgaa tatatgttag atttgcaacc agagacaact       60

ggcctctacg gctatggcca attaaatgac agctcagagg aggaggatga aatagatggt      120

ccagctggac aagcagaacc ggacagagcc cattacaata ttgtaacctt ttgttgcaag      180

tgtgactcta cgcttcggtt gtgcgtacaa agcacacacg tagacattcg tactttggaa      240

gacctgttaa tgggcacact aggaattgtg tgccccatct gttctcagaa accataa         297


<210> 38
<211> 297
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
atgcacggcg acacccccac cttgcacgag tacatgttgg acttgcagcc cgagaccacc       60

ggcctgtacg gctacggcca gttgaacgac agctccgagg aggaggacga gatcgacggc      120

cccgccggcc aggccgagcc cgaccgcgcc cactacaaca tcgtgacctt ctgctgcaag      180

tgcgactcca ccctgcgcct gtgcgtgcag agcacccacg tggacatccg caccttggag      240

gacctgctga tgggcaccct gggcatcgtg tgccccatct gcagccagaa gccctaa         297


<210> 39
<211> 367
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(367)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 39
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro Gln Glu Arg 
    210                 215                 220                 


Pro Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr Thr Ile His 
225                 230                 235                 240 


Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu Leu Arg Arg 
                245                 250                 255     


Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val Tyr Arg Asp 
            260                 265                 270         


Gly Ser Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe Tyr Ser Lys 
        275                 280                 285             


Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly Thr Thr Leu 
    290                 295                 300                 


Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys Ile 
305                 310                 315                 320 


Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg His Leu Asp 
                325                 330                 335     


Lys Lys Gln Arg Phe His Asn Ile Arg Val Arg Trp Thr Gly Arg Cys 
            340                 345                 350         


Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr Gln Leu 
        355                 360                 365         


<210> 40
<211> 1104
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(1104)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 40
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc caccaaaaga gaactgcaat gtttcaggac      660

ccacaggagc gacccagaaa gttaccacag ttatgcacag agctgcaaac aactatacat      720

gatataatat tagaatgtgt gtactgcaag caacagttac tgcgacgtga ggtatatgac      780

tttgcttttc gggatttatg catagtatat agagatggga atccatatgc tgtatgtgat      840

aaatgtttaa agttttattc taaaattagt gagtatagac attattgtta tagtttgtat      900

ggaacaacat tagaacagca atacaacaaa ccgttgtgtg atttgttaat taggtgtatt      960

aactgtcaaa agccactgtg tcctgaagaa aagcaaagac atctggacaa aaagcaaaga     1020

ttccataata taagggtgcg gtggaccggt cgatgtatgt cttgttgcag atcatcaaga     1080

acacgtagag aaacccagct gtaa                                            1104


<210> 41
<211> 1104
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(399)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 41
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc caccagaagc gcaccgccat gttccaggac      660

ccccaggagc gcccccgcaa gctgccccag ctgtgcaccg agctgcagac caccatccac      720

gacatcatcc tggagtgcgt gtactgcaag cagcagctgc tgcgccgcga ggtgtacgac      780

ttcgccttcc gcgacctgtg catcgtgtac cgcgacggca gcccctacgc cgtgtgcgac      840

aagtgcctga agttctactc caagatcagc gagtaccgcc actactgcta cagcctgtac      900

ggcaccaccc tggagcagca gtacaacaag cccctgtgcg acctgctgat ccgctgcatc      960

aactgccaga agcccctgtg ccccgaggag aagcagcgcc acctggacaa gaagcagcgc     1020

ttccacaaca tccgggtgcg gtggaccggg cgctgcatga gctgctgccg cagcagccgc     1080

acccgccgcg agacccagct gtaa                                            1104


<210> 42
<211> 307
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(307)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 42
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro His Gly Asp Thr Pro Thr Leu His Glu Tyr Met Leu Asp Leu 
    210                 215                 220                 


Gln Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu Asn Asp Ser 
225                 230                 235                 240 


Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln Ala Glu Pro 
                245                 250                 255     


Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys Cys Asp Ser 
            260                 265                 270         


Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile Arg Thr Leu 
        275                 280                 285             


Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro Ile Cys Ser 
    290                 295                 300                 


Gln Lys Pro 
305         


<210> 43
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(924)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 43
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc catggagata cacctacatt gcatgaatat      660

atgttagatt tgcaaccaga gacaactggc ctctacggct atggccaatt aaatgacagc      720

tcagaggagg aggatgaaat agatggtcca gctggacaag cagaaccgga cagagcccat      780

tacaatattg taaccttttg ttgcaagtgt gactctacgc ttcggttgtg cgtacaaagc      840

acacacgtag acattcgtac tttggaagac ctgttaatgg gcacactagg aattgtgtgc      900

cccatctgtt ctcagaaacc ataa                                             924


<210> 44
<211> 924
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(924)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 44
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc cacggcgaca cccccacctt gcacgagtac      660

atgttggact tgcagcccga gaccaccggc ctgtacggct acggccagtt gaacgacagc      720

tccgaggagg aggacgagat cgacggcccc gccggccagg ccgagcccga ccgcgcccac      780

tacaacatcg tgaccttctg ctgcaagtgc gactccaccc tgcgcctgtg cgtgcagagc      840

acccacgtgg acatccgcac cttggaggac ctgctgatgg gcaccctggg catcgtgtgc      900

cccatctgca gccagaagcc ctaa                                             924


<210> 45
<211> 338
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(338)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 45
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro His Gln Lys Arg Thr Ala Met Phe Gln Asp Pro 
            180                 185                 190         


Gln Glu Arg Pro Arg Lys Leu Pro Gln Leu Cys Thr Glu Leu Gln Thr 
        195                 200                 205             


Thr Ile His Asp Ile Ile Leu Glu Cys Val Tyr Cys Lys Gln Gln Leu 
    210                 215                 220                 


Leu Arg Arg Glu Val Tyr Asp Phe Ala Phe Arg Asp Leu Cys Ile Val 
225                 230                 235                 240 


Tyr Arg Asp Gly Ser Pro Tyr Ala Val Cys Asp Lys Cys Leu Lys Phe 
                245                 250                 255     


Tyr Ser Lys Ile Ser Glu Tyr Arg His Tyr Cys Tyr Ser Leu Tyr Gly 
            260                 265                 270         


Thr Thr Leu Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile 
        275                 280                 285             


Arg Cys Ile Asn Cys Gln Lys Pro Leu Cys Pro Glu Glu Lys Gln Arg 
    290                 295                 300                 


His Leu Asp Lys Lys Gln Arg Phe His Asn Ile Arg Val Arg Trp Thr 
305                 310                 315                 320 


Gly Arg Cys Met Ser Cys Cys Arg Ser Ser Arg Thr Arg Arg Glu Thr 
                325                 330                 335     


Gln Leu 
        


<210> 46
<211> 1017
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(1017)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 46
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccccaccaaa agagaactgc aatgtttcag gacccacagg agcgacccag aaagttacca      600

cagttatgca cagagctgca aacaactata catgatataa tattagaatg tgtgtactgc      660

aagcaacagt tactgcgacg tgaggtatat gactttgctt ttcgggattt atgcatagta      720

tatagagatg ggaatccata tgctgtatgt gataaatgtt taaagtttta ttctaaaatt      780

agtgagtata gacattattg ttatagtttg tatggaacaa cattagaaca gcaatacaac      840

aaaccgttgt gtgatttgtt aattaggtgt attaactgtc aaaagccact gtgtcctgaa      900

gaaaagcaaa gacatctgga caaaaagcaa agattccata atataagggt gcggtggacc      960

ggtcgatgta tgtcttgttg cagatcatca agaacacgta gagaaaccca gctgtaa        1017


<210> 47
<211> 1017
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(1017)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 47
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccccaccaga agcgcaccgc catgttccag gacccccagg agcgcccccg caagctgccc      600

cagctgtgca ccgagctgca gaccaccatc cacgacatca tcctggagtg cgtgtactgc      660

aagcagcagc tgctgcgccg cgaggtgtac gacttcgcct tccgcgacct gtgcatcgtg      720

taccgcgacg gcagccccta cgccgtgtgc gacaagtgcc tgaagttcta ctccaagatc      780

agcgagtacc gccactactg ctacagcctg tacggcacca ccctggagca gcagtacaac      840

aagcccctgt gcgacctgct gatccgctgc atcaactgcc agaagcccct gtgccccgag      900

gagaagcagc gccacctgga caagaagcag cgcttccaca acatccgggt gcggtggacc      960

gggcgctgca tgagctgctg ccgcagcagc cgcacccgcc gcgagaccca gctgtaa        1017


<210> 48
<211> 278
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(278)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 48
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Gly Pro Gly Pro His Gly Asp Thr Pro Thr Leu His Glu Tyr Met 
            180                 185                 190         


Leu Asp Leu Gln Pro Glu Thr Thr Gly Leu Tyr Gly Tyr Gly Gln Leu 
        195                 200                 205             


Asn Asp Ser Ser Glu Glu Glu Asp Glu Ile Asp Gly Pro Ala Gly Gln 
    210                 215                 220                 


Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys Lys 
225                 230                 235                 240 


Cys Asp Ser Thr Leu Arg Leu Cys Val Gln Ser Thr His Val Asp Ile 
                245                 250                 255     


Arg Thr Leu Glu Asp Leu Leu Met Gly Thr Leu Gly Ile Val Cys Pro 
            260                 265                 270         


Ile Cys Ser Gln Lys Pro 
        275             


<210> 49
<211> 837
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(837)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 49
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccccatggag atacacctac attgcatgaa tatatgttag atttgcaacc agagacaact      600

ggcctctacg gctatggcca attaaatgac agctcagagg aggaggatga aatagatggt      660

ccagctggac aagcagaacc ggacagagcc cattacaata ttgtaacctt ttgttgcaag      720

tgtgactcta cgcttcggtt gtgcgtacaa agcacacacg tagacattcg tactttggaa      780

gacctgttaa tgggcacact aggaattgtg tgccccatct gttctcagaa accataa         837


<210> 50
<211> 837
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(837)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 50
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gggacctggg      540

ccccacggcg acacccccac cttgcacgag tacatgttgg acttgcagcc cgagaccacc      600

ggcctgtacg gctacggcca gttgaacgac agctccgagg aggaggacga gatcgacggc      660

cccgccggcc aggccgagcc cgaccgcgcc cactacaaca tcgtgacctt ctgctgcaag      720

tgcgactcca ccctgcgcct gtgcgtgcag agcacccacg tggacatccg caccttggag      780

gacctgctga tgggcaccct gggcatcgtg tgccccatct gcagccagaa gccctaa         837


<210> 51
<211> 325
<212> PRT
<213> Mycobacterium tuberculosis

<400> 51
Met Thr Asp Val Ser Arg Lys Ile Arg Ala Trp Gly Arg Arg Leu Met 
1               5                   10                  15      


Ile Gly Thr Ala Ala Ala Val Val Leu Pro Gly Leu Val Gly Leu Ala 
            20                  25                  30          


Gly Gly Ala Ala Thr Ala Gly Ala Phe Ser Arg Pro Gly Leu Pro Val 
        35                  40                  45              


Glu Tyr Leu Gln Val Pro Ser Pro Ser Met Gly Arg Asp Ile Lys Val 
    50                  55                  60                  


Gln Phe Gln Ser Gly Gly Asn Asn Ser Pro Ala Val Tyr Leu Leu Asp 
65                  70                  75                  80  


Gly Leu Arg Ala Gln Asp Asp Tyr Asn Gly Trp Asp Ile Asn Thr Pro 
                85                  90                  95      


Ala Phe Glu Trp Tyr Tyr Gln Ser Gly Leu Ser Ile Val Met Pro Val 
            100                 105                 110         


Gly Gly Gln Ser Ser Phe Tyr Ser Asp Trp Tyr Ser Pro Ala Cys Gly 
        115                 120                 125             


Lys Ala Gly Cys Gln Thr Tyr Lys Trp Glu Thr Phe Leu Thr Ser Glu 
    130                 135                 140                 


Leu Pro Gln Trp Leu Ser Ala Asn Arg Ala Val Lys Pro Thr Gly Ser 
145                 150                 155                 160 


Ala Ala Ile Gly Leu Ser Met Ala Gly Ser Ser Ala Met Ile Leu Ala 
                165                 170                 175     


Ala Tyr His Pro Gln Gln Phe Ile Tyr Ala Gly Ser Leu Ser Ala Leu 
            180                 185                 190         


Leu Asp Pro Ser Gln Gly Met Gly Pro Ser Leu Ile Gly Leu Ala Met 
        195                 200                 205             


Gly Asp Ala Gly Gly Tyr Lys Ala Ala Asp Met Trp Gly Pro Ser Ser 
    210                 215                 220                 


Asp Pro Ala Trp Glu Arg Asn Asp Pro Thr Gln Gln Ile Pro Lys Leu 
225                 230                 235                 240 


Val Ala Asn Asn Thr Arg Leu Trp Val Tyr Cys Gly Asn Gly Thr Pro 
                245                 250                 255     


Asn Glu Leu Gly Gly Ala Asn Ile Pro Ala Glu Phe Leu Glu Asn Phe 
            260                 265                 270         


Val Arg Ser Ser Asn Leu Lys Phe Gln Asp Ala Tyr Asn Ala Ala Gly 
        275                 280                 285             


Gly His Asn Ala Val Phe Asn Phe Pro Pro Asn Gly Thr His Ser Trp 
    290                 295                 300                 


Glu Tyr Trp Gly Ala Gln Leu Asn Ala Met Lys Gly Asp Leu Gln Ser 
305                 310                 315                 320 


Ser Leu Gly Ala Gly 
                325 


<210> 52
<211> 40
<212> PRT
<213> Mycobacterium tuberculosis

<400> 52
Met Thr Asp Val Ser Arg Lys Ile Arg Ala Trp Gly Arg Arg Leu Met 
1               5                   10                  15      


Ile Gly Thr Ala Ala Ala Val Val Leu Pro Gly Leu Val Gly Leu Ala 
            20                  25                  30          


Gly Gly Ala Ala Thr Ala Gly Ala 
        35                  40  


<210> 53
<211> 285
<212> PRT
<213> Mycobacterium tuberculosis

<400> 53
Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro Ser Pro 
1               5                   10                  15      


Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly Asn Asn 
            20                  25                  30          


Ser Pro Ala Val Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp Asp Tyr 
        35                  40                  45              


Asn Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Tyr Gln Ser 
    50                  55                  60                  


Gly Leu Ser Ile Val Met Pro Val Gly Gly Gln Ser Ser Phe Tyr Ser 
65                  70                  75                  80  


Asp Trp Tyr Ser Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr Tyr Lys 
                85                  90                  95      


Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gln Trp Leu Ser Ala Asn 
            100                 105                 110         


Arg Ala Val Lys Pro Thr Gly Ser Ala Ala Ile Gly Leu Ser Met Ala 
        115                 120                 125             


Gly Ser Ser Ala Met Ile Leu Ala Ala Tyr His Pro Gln Gln Phe Ile 
    130                 135                 140                 


Tyr Ala Gly Ser Leu Ser Ala Leu Leu Asp Pro Ser Gln Gly Met Gly 
145                 150                 155                 160 


Pro Ser Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr Lys Ala 
                165                 170                 175     


Ala Asp Met Trp Gly Pro Ser Ser Asp Pro Ala Trp Glu Arg Asn Asp 
            180                 185                 190         


Pro Thr Gln Gln Ile Pro Lys Leu Val Ala Asn Asn Thr Arg Leu Trp 
        195                 200                 205             


Val Tyr Cys Gly Asn Gly Thr Pro Asn Glu Leu Gly Gly Ala Asn Ile 
    210                 215                 220                 


Pro Ala Glu Phe Leu Glu Asn Phe Val Arg Ser Ser Asn Leu Lys Phe 
225                 230                 235                 240 


Gln Asp Ala Tyr Asn Ala Ala Gly Gly His Asn Ala Val Phe Asn Phe 
                245                 250                 255     


Pro Pro Asn Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln Leu Asn 
            260                 265                 270         


Ala Met Lys Gly Asp Leu Gln Ser Ser Leu Gly Ala Gly 
        275                 280                 285 


<210> 54
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro 
    210                 215                 220                 


Ser Pro Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Asn Asn Ser Pro Ala Val Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp 
                245                 250                 255     


Asp Tyr Asn Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Tyr 
            260                 265                 270         


Gln Ser Gly Leu Ser Ile Val Met Pro Val Gly Gly Gln Ser Ser Phe 
        275                 280                 285             


Tyr Ser Asp Trp Tyr Ser Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr 
    290                 295                 300                 


Tyr Lys Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gln Trp Leu Ser 
305                 310                 315                 320 


Ala Asn Arg Ala Val Lys Pro Thr Gly Ser Ala Ala Ile Gly Leu Ser 
                325                 330                 335     


Met Ala Gly Ser Ser Ala Met Ile Leu Ala Ala Tyr His Pro Gln Gln 
            340                 345                 350         


Phe Ile Tyr Ala Gly Ser Leu Ser Ala Leu Leu Asp Pro Ser Gln Gly 
        355                 360                 365             


Met Gly Pro Ser Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr 
    370                 375                 380                 


Lys Ala Ala Asp Met Trp Gly Pro Ser Ser Asp Pro Ala Trp Glu Arg 
385                 390                 395                 400 


Asn Asp Pro Thr Gln Gln Ile Pro Lys Leu Val Ala Asn Asn Thr Arg 
                405                 410                 415     


Leu Trp Val Tyr Cys Gly Asn Gly Thr Pro Asn Glu Leu Gly Gly Ala 
            420                 425                 430         


Asn Ile Pro Ala Glu Phe Leu Glu Asn Phe Val Arg Ser Ser Asn Leu 
        435                 440                 445             


Lys Phe Gln Asp Ala Tyr Asn Ala Ala Gly Gly His Asn Ala Val Phe 
    450                 455                 460                 


Asn Phe Pro Pro Asn Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln 
465                 470                 475                 480 


Leu Asn Ala Met Lys Gly Asp Leu Gln Ser Ser Leu Gly Ala Gly 
                485                 490                 495 


<210> 55
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 55
Gly Pro Gly Pro 
1               


<210> 56
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 56
tatagggccc catggagata cacc                                              24


<210> 57
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 57
tatcgtcgac ttatggttct gggaaca                                           27


<210> 58
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 58
caccatcacc atcaccat                                                     18


<210> 59
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 59
aatgtttcag gacccacagg                                                   20


<210> 60
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 60
ttgtttgcag ctctgtgcat                                                   20


<210> 61
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 61
caagtgtgac tctacgcttc gg                                                22


<210> 62
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 62
gtggcccatt aacaggtctt ccaa                                              24


<210> 63
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 63
Cys Ile Val Tyr Arg Asp Gly Asn Pro Tyr Ala Val Cys Asp Lys Cys 
1               5                   10                  15      


<210> 64
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 64
Glu Gln Gln Tyr Asn Lys Pro Leu Cys Asp Leu Leu Ile Arg Cys 
1               5                   10                  15  


<210> 65
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 65
Lys Leu Pro Gln Leu Cys Thr Glu Leu 
1               5                   


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Tyr Asp Phe Ala Phe Arg Asp Leu 
1               5               


<210> 67
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 67
Arg Cys Ile Asn Cys Gln Lys Pro Leu 
1               5                   


<210> 68
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 68
Asp Lys Lys Gln Arg Phe Met Asn Ile 
1               5                   


<210> 69
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 69
Gln Ala Glu Pro Asp Arg Ala His Tyr Asn Ile Val Thr Phe Cys Cys 
1               5                   10                  15      


Lys 
    


<210> 70
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 70
Asp Leu Tyr Cys Tyr Glu Gln Leu 
1               5               


<210> 71
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Arg Ala His Tyr Asn Ile Val Thr Phe 
1               5                   


<210> 72
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Leu Cys Val Gln Ser Thr His Val Asp 
1               5                   


<210> 73
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Ile Thr Gln Met Tyr Thr Asn Val 
1               5               


<210> 74
<211> 1488
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 74
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc tttagcaggc ctggcctgcc cgtggaatac      660

ctgcaagtgc cttcccctag catgggaaga gatattaagg tgcagttcca gagcggcgga      720

aacaacagcc ccgctgttta cctgctcgac ggcctgagag cccaggatga ctacaacggc      780

tgggacatca acacccctgc cttcgagtgg tactaccagt ctggcctgtc tatcgtgatg      840

ccagtgggcg gccagagcag cttctacagc gactggtata gccctgcctg cggcaaggcc      900

ggttgtcaga cctacaaatg ggagacattc ctgaccagcg agctgcctca gtggctgtcc      960

gccaatcggg cggtcaagcc aaccggcagc gccgctatcg gcctgagcat ggccggcagc     1020

agcgccatga tcctggccgc ttatcacccc caacaattta tctacgccgg ctccctgagc     1080

gccctgctgg accccagcca gggcatggga cctagcctga tcggacttgc tatgggcgat     1140

gctggaggct acaaggccgc cgacatgtgg ggaccttctt ctgatcctgc ctgggagaga     1200

aacgacccta cacagcagat ccccaagctg gtggccaaca ataccagact gtgggtgtac     1260

tgcggcaacg gaacacctaa cgagctgggc ggagccaaca tccctgccga gttcctggaa     1320

aacttcgtgc ggagctctaa tctgaagttc caggacgcct acaatgccgc cggcggccac     1380

aacgccgtgt tcaacttccc acctaacggc acccacagct gggaatactg gggcgctcag     1440

ctgaacgcca tgaaaggcga cctgcagtcc tctctgggag ccggatga                  1488


<210> 75
<211> 95
<212> PRT
<213> Mycobacterium tuberculosis

<400> 75
Met Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala Ser 
1               5                   10                  15      


Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Glu Gly 
            20                  25                  30          


Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp Gly Gly Ser Gly Ser 
        35                  40                  45              


Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu 
    50                  55                  60                  


Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala Gly 
65                  70                  75                  80  


Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr Gly Met Phe Ala 
                85                  90                  95  


<210> 76
<211> 33
<212> PRT
<213> Mycobacterium tuberculosis

<400> 76
Ile Glu Ala Ala Ala Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His 
1               5                   10                  15      


Ser Leu Leu Asp Glu Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala 
            20                  25                  30          


Trp 
    


<210> 77
<211> 37
<212> PRT
<213> Mycobacterium tuberculosis

<400> 77
Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr Glu 
1               5                   10                  15      


Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala Gly 
            20                  25                  30          


Gln Ala Met Ala Ser 
        35          


<210> 78
<211> 304
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 78
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Ile Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala 
    210                 215                 220                 


Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Glu 
225                 230                 235                 240 


Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp Gly Gly Ser Gly 
                245                 250                 255     


Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr 
            260                 265                 270         


Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala 
        275                 280                 285             


Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr Gly Met Phe Ala 
    290                 295                 300                 


<210> 79
<211> 915
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 79
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccagggatca gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc accgagcagc aatggaactt cgccggcatc      660

gaggccgctg cttccgccat ccagggcaac gtgaccagca tccacagcct gctggacgag      720

ggcaagcaga gcctgaccaa gctggccgcc gcttggggcg gatctggctc tgaagcctac      780

cagggcgtgc agcagaaatg ggatgccaca gccacagaac tgaacaacgc cctgcagaac      840

ctggctagaa ccatcagcga ggccggacag gccatggcca gcaccgaagg caatgtgaca      900

ggcatgttcg cctga                                                       915


<210> 80
<211> 35
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 80
taatacgact cactataggg cgccaccatg gtgag                                  35


<210> 81
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 81
tgcagtgaaa aaaatgcttt atttg                                             25


<210> 82
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 82
taatacgact cactataggg cgccaccatg cacggc                                 36


<210> 83
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 83
gtcgacttag ggcttctggc t                                                 21


<210> 84
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 84
tgacacctac tcagacaatg cgatg                                             25


<210> 85
<211> 495
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(495)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 85
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Phe Ser Arg Pro Gly Leu Pro Val Glu Tyr Leu Gln Val Pro 
    210                 215                 220                 


Ser Pro Ser Met Gly Arg Asp Ile Lys Val Gln Phe Gln Ser Gly Gly 
225                 230                 235                 240 


Asn Asn Ser Pro Ala Val Tyr Leu Leu Asp Gly Leu Arg Ala Gln Asp 
                245                 250                 255     


Asp Tyr Asn Gly Trp Asp Ile Asn Thr Pro Ala Phe Glu Trp Tyr Tyr 
            260                 265                 270         


Gln Ser Gly Leu Ser Ile Val Met Pro Val Gly Gly Gln Ser Ser Phe 
        275                 280                 285             


Tyr Ser Asp Trp Tyr Ser Pro Ala Cys Gly Lys Ala Gly Cys Gln Thr 
    290                 295                 300                 


Tyr Lys Trp Glu Thr Phe Leu Thr Ser Glu Leu Pro Gln Trp Leu Ser 
305                 310                 315                 320 


Ala Asn Arg Ala Val Lys Pro Thr Gly Ser Ala Ala Ile Gly Leu Ser 
                325                 330                 335     


Met Ala Gly Ser Ser Ala Met Ile Leu Ala Ala Tyr His Pro Gln Gln 
            340                 345                 350         


Phe Ile Tyr Ala Gly Ser Leu Ser Ala Leu Leu Asp Pro Ser Gln Gly 
        355                 360                 365             


Met Gly Pro Ser Leu Ile Gly Leu Ala Met Gly Asp Ala Gly Gly Tyr 
    370                 375                 380                 


Lys Ala Ala Asp Met Trp Gly Pro Ser Ser Asp Pro Ala Trp Glu Arg 
385                 390                 395                 400 


Asn Asp Pro Thr Gln Gln Ile Pro Lys Leu Val Ala Asn Asn Thr Arg 
                405                 410                 415     


Leu Trp Val Tyr Cys Gly Asn Gly Thr Pro Asn Glu Leu Gly Gly Ala 
            420                 425                 430         


Asn Ile Pro Ala Glu Phe Leu Glu Asn Phe Val Arg Ser Ser Asn Leu 
        435                 440                 445             


Lys Phe Gln Asp Ala Tyr Asn Ala Ala Gly Gly His Asn Ala Val Phe 
    450                 455                 460                 


Asn Phe Pro Pro Asn Gly Thr His Ser Trp Glu Tyr Trp Gly Ala Gln 
465                 470                 475                 480 


Leu Asn Ala Met Lys Gly Asp Leu Gln Ser Ser Leu Gly Ala Gly 
                485                 490                 495 


<210> 86
<211> 1488
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(1488)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 86
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc tttagcaggc ctggcctgcc cgtggaatac      660

ctgcaagtgc cttcccctag catgggaaga gatattaagg tgcagttcca gagcggcgga      720

aacaacagcc ccgctgttta cctgctcgac ggcctgagag cccaggatga ctacaacggc      780

tgggacatca acacccctgc cttcgagtgg tactaccagt ctggcctgtc tatcgtgatg      840

ccagtgggcg gccagagcag cttctacagc gactggtata gccctgcctg cggcaaggcc      900

ggttgtcaga cctacaaatg ggagacattc ctgaccagcg agctgcctca gtggctgtcc      960

gccaatcggg cggtcaagcc aaccggcagc gccgctatcg gcctgagcat ggccggcagc     1020

agcgccatga tcctggccgc ttatcacccc caacaattta tctacgccgg ctccctgagc     1080

gccctgctgg accccagcca gggcatggga cctagcctga tcggacttgc tatgggcgat     1140

gctggaggct acaaggccgc cgacatgtgg ggaccttctt ctgatcctgc ctgggagaga     1200

aacgacccta cacagcagat ccccaagctg gtggccaaca ataccagact gtgggtgtac     1260

tgcggcaacg gaacacctaa cgagctgggc ggagccaaca tccctgccga gttcctggaa     1320

aacttcgtgc ggagctctaa tctgaagttc caggacgcct acaatgccgc cggcggccac     1380

aacgccgtgt tcaacttccc acctaacggc acccacagct gggaatactg gggcgctcag     1440

ctgaacgcca tgaaaggcga cctgcagtcc tctctgggag ccggatga                  1488


<210> 87
<211> 304
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"


<220>
<221> VARIANT
<222> (133)..(133)
<223> /replace="Ile" or "Leu"

<220>
<221> SITE
<222> (1)..(304)
<223> /note="Variant residues given in the sequence have no
      preference with respect to those in the annotations
      for variant positions" 

<400> 87
Met Gly Cys Lys Trp Ser Lys Ser Ser Val Val Gly Trp Pro Ala Val 
1               5                   10                  15      


Arg Glu Arg Met Arg Arg Ala Glu Pro Ala Ala Asp Gly Val Gly Ala 
            20                  25                  30          


Ala Ser Arg Asp Leu Glu Lys His Gly Ala Ile Thr Ser Ser Asn Thr 
        35                  40                  45              


Ala Ala Thr Asn Ala Asp Cys Ala Trp Leu Glu Ala Gln Glu Glu Glu 
    50                  55                  60                  


Glu Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr 
65                  70                  75                  80  


Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly 
                85                  90                  95      


Leu Glu Gly Leu Ile His Ser Gln Arg Arg Gln Asp Ile Leu Asp Leu 
            100                 105                 110         


Trp Ile Tyr His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr 
        115                 120                 125             


Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Cys Tyr Lys 
    130                 135                 140                 


Leu Val Pro Val Glu Pro Glu Lys Leu Glu Glu Ala Asn Lys Gly Glu 
145                 150                 155                 160 


Asn Thr Ser Leu Leu His Pro Val Ser Leu His Gly Met Asp Asp Pro 
                165                 170                 175     


Gly Arg Glu Val Leu Glu Trp Arg Phe Asp Ser Arg Leu Ala Phe His 
            180                 185                 190         


His Val Ala Arg Glu Leu His Pro Glu Tyr Phe Lys Asn Cys Gly Pro 
        195                 200                 205             


Gly Pro Thr Glu Gln Gln Trp Asn Phe Ala Gly Ile Glu Ala Ala Ala 
    210                 215                 220                 


Ser Ala Ile Gln Gly Asn Val Thr Ser Ile His Ser Leu Leu Asp Glu 
225                 230                 235                 240 


Gly Lys Gln Ser Leu Thr Lys Leu Ala Ala Ala Trp Gly Gly Ser Gly 
                245                 250                 255     


Ser Glu Ala Tyr Gln Gly Val Gln Gln Lys Trp Asp Ala Thr Ala Thr 
            260                 265                 270         


Glu Leu Asn Asn Ala Leu Gln Asn Leu Ala Arg Thr Ile Ser Glu Ala 
        275                 280                 285             


Gly Gln Ala Met Ala Ser Thr Glu Gly Asn Val Thr Gly Met Phe Ala 
    290                 295                 300                 


<210> 88
<211> 915
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"


<220>
<221> variation
<222> (397)..(399)
<223> /replace="atc" or "ata" or "att" or "cta" or "ctc" or "ctg"
      or "ctt" or "gta" or "gtc" or "gtg" or "tta" or "ttg"

<220>
<221> misc_feature
<222> (1)..(915)
<223> /note="Variant nucleotides given in the sequence have no 
      preference with respect to those in the annotations 
      for variant positions"

<400> 88
atgggttgca agtggtcaaa aagtagtgtg gttggatggc ctgctgtaag ggaaagaatg       60

agacgagctg agccagcagc agatggggtg ggagcagcat ctcgagacct agaaaaacat      120

ggagcaatca caagtagcaa tacagcagct accaatgctg attgtgcctg gctagaagca      180

caagaggagg aggaggtggg ttttccagtc acacctcagg tacctttaag accaatgact      240

tacaaggcag ctgtagatct tagccacttt ttaaaagaaa aggggggact ggaagggcta      300

attcactccc aacgaagaca agatatcctt gatctgtgga tctaccacac acaaggctac      360

ttccctgatt ggcagaacta cacaccagga ccaggggtta gatatccact gacctttgga      420

tggtgctaca agctagtacc agttgagcca gagaagttag aagaagccaa caaaggagag      480

aacaccagct tgttacaccc tgtgagcctg catggaatgg atgacccggg gagagaagtg      540

ttagagtgga ggtttgacag ccgcctagca tttcatcacg tggcccgaga gctgcatccg      600

gagtacttca agaactgcgg acctgggccc accgagcagc aatggaactt cgccggcatc      660

gaggccgctg cttccgccat ccagggcaac gtgaccagca tccacagcct gctggacgag      720

ggcaagcaga gcctgaccaa gctggccgcc gcttggggcg gatctggctc tgaagcctac      780

cagggcgtgc agcagaaatg ggatgccaca gccacagaac tgaacaacgc cctgcagaac      840

ctggctagaa ccatcagcga ggccggacag gccatggcca gcaccgaagg caatgtgaca      900

ggcatgttcg cctga                                                       915


<210> 89
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 89
His His His His His His 
1               5       


<210> 90
<211> 80
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 90
tacttcaaga actgcggacc tgggcccggc caatctttcc cgggggtacc gtcgactgcg       60

gccgcgaatt ccaagctttg                                                   80


<210> 91
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 91
taatacgact cactataggg cgccaccatg                                        30


