                               SEQUENCE LISTING

<110> LARIMAR THERAPEUTICS, INC.
 
<120> METHODS FOR TREATING MYELIN ASSOCIATED DISEASES AND MITOCHONDRIA 
      ASSOCIATED DISEASES

<130> 130197-01120

<140>
<141>

<150> 63/018,451
<151> 2020-04-30

<160> 57    

<170> PatentIn version 3.5

<210> 1
<211> 210
<212> PRT
<213> Homo sapiens

<400> 1
Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro 
1               5                   10                  15      


Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu 
            20                  25                  30          


Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala 
        35                  40                  45              


Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln 
    50                  55                  60                  


Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys 
65                  70                  75                  80  


Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
                85                  90                  95      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            100                 105                 110         


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        115                 120                 125             


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    130                 135                 140                 


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
145                 150                 155                 160 


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                165                 170                 175     


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            180                 185                 190         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        195                 200                 205             


Asp Ala 
    210 


<210> 2
<211> 130
<212> PRT
<213> Homo sapiens

<400> 2
Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu 
1               5                   10                  15      


Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp 
            20                  25                  30          


Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly 
        35                  40                  45              


Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val 
    50                  55                  60                  


Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser 
65                  70                  75                  80  


Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser 
                85                  90                  95      


His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys 
            100                 105                 110         


Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys 
        115                 120                 125             


Asp Ala 
    130 


<210> 3
<211> 11
<212> PRT
<213> Human immunodeficiency virus

<400> 3
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10      


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 4
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10          


<210> 5
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Pro His Ala Val 
1               5                   10                  15      


Gly Asn His Arg Ser Phe Ser Asp Lys Asn Gly Leu Thr Ser 
            20                  25                  30  


<210> 6
<211> 14
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 6
Ile Asn Leu Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
1               5                   10                  


<210> 7
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210> 8
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 
1               5                   10                  15      


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210> 10
<211> 34
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Gly Gly Ser Leu Val Pro Arg Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 12
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 13
Gly Ser Gly Ser Gly Ser Gly Ser 
1               5               


<210> 14
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 14
Gly Gly Ser Gly Gly His Met Gly Ser Gly Gly 
1               5                   10      


<210> 15
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly 
1               5                   10      


<210> 16
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Gly Gly Ser Gly Gly 
1               5   


<210> 17
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 17
Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
1               5                   10                  15      


Gly Gly 
        


<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 18
Ala Ala Gly Ala Ala Thr Ala Ala 
1               5               


<210> 19
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 19
Gly Gly Gly Gly Gly 
1               5   


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 20
Gly Gly Ser Ser Gly 
1               5   


<210> 21
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 21
Gly Ser Gly Gly Gly Thr Gly Gly Gly Ser Gly 
1               5                   10      


<210> 22
<211> 224
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 22
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Met Trp 
1               5                   10                  15      


Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro 
            20                  25                  30          


Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala 
        35                  40                  45              


Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys 
    50                  55                  60                  


Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp 
65                  70                  75                  80  


Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly 
                85                  90                  95      


Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu 
            100                 105                 110         


Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala 
        115                 120                 125             


Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly 
    130                 135                 140                 


Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn 
145                 150                 155                 160 


Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly 
                165                 170                 175     


Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp 
            180                 185                 190         


Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu 
        195                 200                 205             


Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 220                 


<210> 23
<211> 76
<212> PRT
<213> Homo sapiens

<400> 23
Met Gln Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu 
1               5                   10                  15      


Val Glu Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp 
            20                  25                  30          


Lys Glu Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys 
        35                  40                  45              


Gln Leu Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu 
    50                  55                  60                  


Ser Thr Leu His Leu Val Leu Arg Leu Arg Gly Gly 
65                  70                  75      


<210> 24
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Caspase cleavage domain sequence"

<400> 24
Asp Glu Val Asp 
1               


<210> 25
<211> 8
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Calpain cleavage domain sequence"

<400> 25
Glu Pro Leu Phe Ala Glu Arg Lys 
1               5               


<210> 26
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Calpain cleavage domain sequence"

<400> 26
Leu Leu Val Tyr 
1               


<210> 27
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Enterokinase (light chain)/Enteropeptidase cleavage site 
      sequence"

<400> 27
Asp Asp Asp Asp Lys 
1               5   


<210> 28
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      PreScission Protease/human Rhinovirus protease (HRV 3C) 
      cleavage site sequence"

<400> 28
Leu Glu Val Leu Phe Gln Pro 
1               5           


<210> 29
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      TEV protease cleavage site sequence"

<400> 29
Leu Glu Val Leu Phe Gly Pro 
1               5           


<210> 30
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      TEV protease cleavage site sequence"

<400> 30
Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 31
Glu Xaa Xaa Tyr Xaa Gln Gly 
1               5           


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> MOD_RES
<222> (2)..(3)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (5)..(5)
<223> Any amino acid

<400> 32
Glu Xaa Xaa Tyr Xaa Gln Ser 
1               5           


<210> 33
<211> 7
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      TVMV protease cleavage site sequence"

<400> 33
Glu Thr Val Arg Phe Gln Ser 
1               5           


<210> 34
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Factor Xa protease cleavage site sequence"

<400> 34
Ile Glu Gly Arg 
1               


<210> 35
<211> 4
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Factor Xa protease cleavage site sequence"

<400> 35
Ile Asp Gly Arg 
1               


<210> 36
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Thrombin cleavage site sequence"

<400> 36
Leu Val Pro Arg Ser 
1               5   


<210> 37
<211> 5
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      Thrombin cleavage site sequence"

<400> 37
Leu Val Pro Gly Ser 
1               5   


<210> 38
<211> 97
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      SUMO1 sequence"

<400> 38
Met Ser Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys 
1               5                   10                  15      


Lys Glu Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser 
            20                  25                  30          


Glu Ile His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys 
        35                  40                  45              


Glu Ser Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe 
    50                  55                  60                  


Leu Phe Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu 
65                  70                  75                  80  


Gly Met Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly 
                85                  90                  95      


Gly 
    


<210> 39
<211> 95
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      SUMO2 sequence"

<400> 39
Met Ala Asp Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asn Asp 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly 
    50                  55                  60                  


Gln Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Tyr 
                85                  90                  95  


<210> 40
<211> 103
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      SUMO3 sequence"

<400> 40
Met Ser Glu Glu Lys Pro Lys Glu Gly Val Lys Thr Glu Asn Asp His 
1               5                   10                  15      


Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe Lys 
            20                  25                  30          


Ile Lys Arg His Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys Glu 
        35                  40                  45              


Arg Gln Gly Leu Ser Met Arg Gln Ile Arg Phe Arg Phe Asp Gly Gln 
    50                  55                  60                  


Pro Ile Asn Glu Thr Asp Thr Pro Ala Gln Leu Glu Met Glu Asp Glu 
65                  70                  75                  80  


Asp Thr Ile Asp Val Phe Gln Gln Gln Thr Gly Gly Val Pro Glu Ser 
                85                  90                  95      


Ser Leu Ala Gly His Ser Phe 
            100             


<210> 41
<211> 95
<212> PRT
<213> Unknown

<220>
<221> source
<223> /note="Description of Unknown: 
      SUMO4 sequence"

<400> 41
Met Ala Asn Glu Lys Pro Thr Glu Glu Val Lys Thr Glu Asn Asn Asn 
1               5                   10                  15      


His Ile Asn Leu Lys Val Ala Gly Gln Asp Gly Ser Val Val Gln Phe 
            20                  25                  30          


Lys Ile Lys Arg Gln Thr Pro Leu Ser Lys Leu Met Lys Ala Tyr Cys 
        35                  40                  45              


Glu Pro Arg Gly Leu Ser Met Lys Gln Ile Arg Phe Arg Phe Gly Gly 
    50                  55                  60                  


Gln Pro Ile Ser Gly Thr Asp Lys Pro Ala Gln Leu Glu Met Glu Asp 
65                  70                  75                  80  


Glu Asp Thr Ile Asp Val Phe Gln Gln Pro Thr Gly Gly Val Tyr 
                85                  90                  95  


<210> 42
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Leu Ala Leu Lys Leu Ala Gly Leu Asp Leu 
1               5                   10  


<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu 
1               5                   10  


<210> 44
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Met Gln Glu Leu Ser Asn Ile Leu Asn Leu 
1               5                   10  


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Leu Pro Pro Leu Glu Arg Leu Thr Leu 
1               5                   


<210> 46
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 46
Leu Cys Gln Ala Phe Ser Asp Val Ile Leu 
1               5                   10  


<210> 47
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 47
Arg Thr Phe Asp Met His Ser Leu Glu Ser Ser Leu Ile Asp Ile Met 
1               5                   10                  15      


Arg 
    


<210> 48
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 48
Thr Asn Leu Glu Ala Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu Asp 
1               5                   10                  15      


Glu 
    


<210> 49
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 49
Arg Ser Phe Glu Met Thr Glu Phe Asn Gln Ala Leu Glu Glu Ile Lys 
1               5                   10                  15      


Gly 
    


<210> 50
<211> 321
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 50
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Met Ser 
1               5                   10                  15      


Asp Gln Glu Ala Lys Pro Ser Thr Glu Asp Leu Gly Asp Lys Lys Glu 
            20                  25                  30          


Gly Glu Tyr Ile Lys Leu Lys Val Ile Gly Gln Asp Ser Ser Glu Ile 
        35                  40                  45              


His Phe Lys Val Lys Met Thr Thr His Leu Lys Lys Leu Lys Glu Ser 
    50                  55                  60                  


Tyr Cys Gln Arg Gln Gly Val Pro Met Asn Ser Leu Arg Phe Leu Phe 
65                  70                  75                  80  


Glu Gly Gln Arg Ile Ala Asp Asn His Thr Pro Lys Glu Leu Gly Met 
                85                  90                  95      


Glu Glu Glu Asp Val Ile Glu Val Tyr Gln Glu Gln Thr Gly Gly Met 
            100                 105                 110         


Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser 
        115                 120                 125             


Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu 
    130                 135                 140                 


Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr 
145                 150                 155                 160 


Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile 
                165                 170                 175     


Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser 
            180                 185                 190         


Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg 
        195                 200                 205             


Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu 
    210                 215                 220                 


Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser 
225                 230                 235                 240 


Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile 
                245                 250                 255     


Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser 
            260                 265                 270         


Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His 
        275                 280                 285             


Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala 
    290                 295                 300                 


Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp 
305                 310                 315                 320 


Ala 
    


<210> 51
<211> 321
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Ser Asp 
1               5                   10                  15      


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
            20                  25                  30          


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
        35                  40                  45              


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
    50                  55                  60                  


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr 
65                  70                  75                  80  


Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
                85                  90                  95      


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Met 
            100                 105                 110         


Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser 
        115                 120                 125             


Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu 
    130                 135                 140                 


Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr 
145                 150                 155                 160 


Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile 
                165                 170                 175     


Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser 
            180                 185                 190         


Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg 
        195                 200                 205             


Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu 
    210                 215                 220                 


Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser 
225                 230                 235                 240 


Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile 
                245                 250                 255     


Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser 
            260                 265                 270         


Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His 
        275                 280                 285             


Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala 
    290                 295                 300                 


Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp 
305                 310                 315                 320 


Ala 
    


<210> 52
<211> 300
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 52
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Met Gln 
1               5                   10                  15      


Ile Phe Val Lys Thr Leu Thr Gly Lys Thr Ile Thr Leu Glu Val Glu 
            20                  25                  30          


Pro Ser Asp Thr Ile Glu Asn Val Lys Ala Lys Ile Gln Asp Lys Glu 
        35                  40                  45              


Gly Ile Pro Pro Asp Gln Gln Arg Leu Ile Phe Ala Gly Lys Gln Leu 
    50                  55                  60                  


Glu Asp Gly Arg Thr Leu Ser Asp Tyr Asn Ile Gln Lys Glu Ser Thr 
65                  70                  75                  80  


Leu His Leu Val Leu Arg Leu Arg Gly Gly Met Trp Thr Leu Gly Arg 
                85                  90                  95      


Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro Ala Gln Ala Gln 
            100                 105                 110         


Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala Pro Leu Cys Gly 
        115                 120                 125             


Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys Thr Pro Arg Arg 
    130                 135                 140                 


Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp Asn Val Lys Lys 
145                 150                 155                 160 


Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His 
                165                 170                 175     


Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr 
            180                 185                 190         


Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr 
        195                 200                 205             


Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val 
    210                 215                 220                 


Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro 
225                 230                 235                 240 


Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr 
                245                 250                 255     


Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu 
            260                 265                 270         


His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu 
        275                 280                 285             


Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    290                 295                 300 


<210> 53
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Asp Glu 
1               5                   10                  15      


Val Asp Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala 
            20                  25                  30          


Ser Pro Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro 
        35                  40                  45              


Ala Glu Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile 
    50                  55                  60                  


Asp Ala Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu 
65                  70                  75                  80  


Asn Gln Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu 
                85                  90                  95      


Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr 
            100                 105                 110         


Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe 
        115                 120                 125             


Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser 
    130                 135                 140                 


Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr 
145                 150                 155                 160 


Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser 
                165                 170                 175     


Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val 
            180                 185                 190         


Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu 
        195                 200                 205             


Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser 
    210                 215                 220                 


Gly Lys Asp Ala 
225             


<210> 54
<211> 232
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 54
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Glu Pro 
1               5                   10                  15      


Leu Phe Ala Glu Arg Lys Met Trp Thr Leu Gly Arg Arg Ala Val Ala 
            20                  25                  30          


Gly Leu Leu Ala Ser Pro Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg 
        35                  40                  45              


Val Pro Arg Pro Ala Glu Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu 
    50                  55                  60                  


Arg Thr Asp Ile Asp Ala Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn 
65                  70                  75                  80  


Gln Arg Gly Leu Asn Gln Ile Trp Asn Val Lys Lys Gln Ser Val Tyr 
                85                  90                  95      


Leu Met Asn Leu Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu 
            100                 105                 110         


Asp Glu Thr Thr Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu 
        115                 120                 125             


Ala Glu Phe Phe Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp 
    130                 135                 140                 


Tyr Asp Val Ser Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly 
145                 150                 155                 160 


Asp Leu Gly Thr Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile 
                165                 170                 175     


Trp Leu Ser Ser Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly 
            180                 185                 190         


Lys Asn Trp Val Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu 
        195                 200                 205             


Ala Ala Glu Leu Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser 
    210                 215                 220                 


Leu Ala Tyr Ser Gly Lys Asp Ala 
225                 230         


<210> 55
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Leu Leu 
1               5                   10                  15      


Val Tyr Met Trp Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala 
            20                  25                  30          


Ser Pro Ser Pro Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro 
        35                  40                  45              


Ala Glu Leu Ala Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile 
    50                  55                  60                  


Asp Ala Thr Cys Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu 
65                  70                  75                  80  


Asn Gln Ile Trp Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu 
                85                  90                  95      


Arg Lys Ser Gly Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr 
            100                 105                 110         


Tyr Glu Arg Leu Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe 
        115                 120                 125             


Glu Asp Leu Ala Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser 
    130                 135                 140                 


Phe Gly Ser Gly Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr 
145                 150                 155                 160 


Tyr Val Ile Asn Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser 
                165                 170                 175     


Pro Ser Ser Gly Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val 
            180                 185                 190         


Tyr Ser His Asp Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu 
        195                 200                 205             


Thr Lys Ala Leu Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser 
    210                 215                 220                 


Gly Lys Asp Ala 
225             


<210> 56
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 56
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Met Trp 
1               5                   10                  15      


Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro 
            20                  25                  30          


Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala 
        35                  40                  45              


Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys 
    50                  55                  60                  


Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp 
65                  70                  75                  80  


Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly 
                85                  90                  95      


Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu 
            100                 105                 110         


Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala 
        115                 120                 125             


Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly 
    130                 135                 140                 


Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn 
145                 150                 155                 160 


Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly 
                165                 170                 175     


Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp 
            180                 185                 190         


Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu 
        195                 200                 205             


Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 220                 


Leu Ala Leu Lys Leu Ala Gly Leu Asp Leu 
225                 230                 


<210> 57
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Met Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Gly Gly Met Trp 
1               5                   10                  15      


Thr Leu Gly Arg Arg Ala Val Ala Gly Leu Leu Ala Ser Pro Ser Pro 
            20                  25                  30          


Ala Gln Ala Gln Thr Leu Thr Arg Val Pro Arg Pro Ala Glu Leu Ala 
        35                  40                  45              


Pro Leu Cys Gly Arg Arg Gly Leu Arg Thr Asp Ile Asp Ala Thr Cys 
    50                  55                  60                  


Thr Pro Arg Arg Ala Ser Ser Asn Gln Arg Gly Leu Asn Gln Ile Trp 
65                  70                  75                  80  


Asn Val Lys Lys Gln Ser Val Tyr Leu Met Asn Leu Arg Lys Ser Gly 
                85                  90                  95      


Thr Leu Gly His Pro Gly Ser Leu Asp Glu Thr Thr Tyr Glu Arg Leu 
            100                 105                 110         


Ala Glu Glu Thr Leu Asp Ser Leu Ala Glu Phe Phe Glu Asp Leu Ala 
        115                 120                 125             


Asp Lys Pro Tyr Thr Phe Glu Asp Tyr Asp Val Ser Phe Gly Ser Gly 
    130                 135                 140                 


Val Leu Thr Val Lys Leu Gly Gly Asp Leu Gly Thr Tyr Val Ile Asn 
145                 150                 155                 160 


Lys Gln Thr Pro Asn Lys Gln Ile Trp Leu Ser Ser Pro Ser Ser Gly 
                165                 170                 175     


Pro Lys Arg Tyr Asp Trp Thr Gly Lys Asn Trp Val Tyr Ser His Asp 
            180                 185                 190         


Gly Val Ser Leu His Glu Leu Leu Ala Ala Glu Leu Thr Lys Ala Leu 
        195                 200                 205             


Lys Thr Lys Leu Asp Leu Ser Ser Leu Ala Tyr Ser Gly Lys Asp Ala 
    210                 215                 220                 


Leu Gln Lys Lys Leu Glu Glu Leu Glu Leu 
225                 230                 


