                         SEQUENCE LISTING

<110>  Saliogen Therapeutics, Inc.
       HIGGINS, Joseph J.
       MCMILLAN, Scott
       TABIBIAZAR, Ray
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF FAMILIAL 
       HYPERCHOLESTEROLEMIA AND ELEVATED LOW-DENSITY LIPOPROTEIN 
       CHOLESTEROL

<130>  SAL-001PC/126933-5001

<150>  US 63/017,424
<151>  2020-04-29

<160>  15    

<170>  PatentIn version 3.5

<210>  1
<211>  5173
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  1
gtgcaatcgc gggaagccag ggtttccagc taggacacag caggtcgtga tccgggtcgg       60

gacactgcct ggcagaggct gcgagcatgg ggccctgggg ctggaaattg cgctggaccg      120

tcgccttgct cctcgccgcg gcggggactg cagtgggcga cagatgcgaa agaaacgagt      180

tccagtgcca agacgggaaa tgcatctcct acaagtgggt ctgcgatggc agcgctgagt      240

gccaggatgg ctctgatgag tcccaggaga cgtgcttgtc tgtcacctgc aaatccgggg      300

acttcagctg tgggggccgt gtcaaccgct gcattcctca gttctggagg tgcgatggcc      360

aagtggactg cgacaacggc tcagacgagc aaggctgtcc ccccaagacg tgctcccagg      420

acgagtttcg ctgccacgat gggaagtgca tctctcggca gttcgtctgt gactcagacc      480

gggactgctt ggacggctca gacgaggcct cctgcccggt gctcacctgt ggtcccgcca      540

gcttccagtg caacagctcc acctgcatcc cccagctgtg ggcctgcgac aacgaccccg      600

actgcgaaga tggctcggat gagtggccgc agcgctgtag gggtctttac gtgttccaag      660

gggacagtag cccctgctcg gccttcgagt tccactgcct aagtggcgag tgcatccact      720

ccagctggcg ctgtgatggt ggccccgact gcaaggacaa atctgacgag gaaaactgcg      780

ctgtggccac ctgtcgccct gacgaattcc agtgctctga tggaaactgc atccatggca      840

gccggcagtg tgaccgggaa tatgactgca aggacatgag cgatgaagtt ggctgcgtta      900

atgtgacact ctgcgaggga cccaacaagt tcaagtgtca cagcggcgaa tgcatcaccc      960

tggacaaagt ctgcaacatg gctagagact gccgggactg gtcagatgaa cccatcaaag     1020

agtgcgggac caacgaatgc ttggacaaca acggcggctg ttcccacgtc tgcaatgacc     1080

ttaagatcgg ctacgagtgc ctgtgccccg acggcttcca gctggtggcc cagcgaagat     1140

gcgaagatat cgatgagtgt caggatcccg acacctgcag ccagctctgc gtgaacctgg     1200

agggtggcta caagtgccag tgtgaggaag gcttccagct ggacccccac acgaaggcct     1260

gcaaggctgt gggctccatc gcctacctct tcttcaccaa ccggcacgag gtcaggaaga     1320

tgacgctgga ccggagcgag tacaccagcc tcatccccaa cctgaggaac gtggtcgctc     1380

tggacacgga ggtggccagc aatagaatct actggtctga cctgtcccag agaatgatct     1440

gcagcaccca gcttgacaga gcccacggcg tctcttccta tgacaccgtc atcagcagag     1500

acatccaggc ccccgacggg ctggctgtgg actggatcca cagcaacatc tactggaccg     1560

actctgtcct gggcactgtc tctgttgcgg ataccaaggg cgtgaagagg aaaacgttat     1620

tcagggagaa cggctccaag ccaagggcca tcgtggtgga tcctgttcat ggcttcatgt     1680

actggactga ctggggaact cccgccaaga tcaagaaagg gggcctgaat ggtgtggaca     1740

tctactcgct ggtgactgaa aacattcagt ggcccaatgg catcacccta gatctcctca     1800

gtggccgcct ctactgggtt gactccaaac ttcactccat ctcaagcatc gatgtcaacg     1860

ggggcaaccg gaagaccatc ttggaggatg aaaagaggct ggcccacccc ttctccttgg     1920

ccgtctttga ggacaaagta ttttggacag atatcatcaa cgaagccatt ttcagtgcca     1980

accgcctcac aggttccgat gtcaacttgt tggctgaaaa cctactgtcc ccagaggata     2040

tggttctctt ccacaacctc acccagccaa gaggagtgaa ctggtgtgag aggaccaccc     2100

tgagcaatgg cggctgccag tatctgtgcc tccctgcccc gcagatcaac ccccactcgc     2160

ccaagtttac ctgcgcctgc ccggacggca tgctgctggc cagggacatg aggagctgcc     2220

tcacagaggc tgaggctgca gtggccaccc aggagacatc caccgtcagg ctaaaggtca     2280

gctccacagc cgtaaggaca cagcacacaa ccacccgacc tgttcccgac acctcccggc     2340

tgcctggggc cacccctggg ctcaccacgg tggagatagt gacaatgtct caccaagctc     2400

tgggcgacgt tgctggcaga ggaaatgaga agaagcccag tagcgtgagg gctctgtcca     2460

ttgtcctccc catcgtgctc ctcgtcttcc tttgcctggg ggtcttcctt ctatggaaga     2520

actggcggct taagaacatc aacagcatca actttgacaa ccccgtctat cagaagacca     2580

cagaggatga ggtccacatt tgccacaacc aggacggcta cagctacccc tcgagacaga     2640

tggtcagtct ggaggatgac gtggcgtgaa catctgcctg gagtcccgtc cctgcccaga     2700

acccttcctg agacctcgcc ggccttgttt tattcaaaga cagagaagac caaagcattg     2760

cctgccagag ctttgtttta tatatttatt catctgggag gcagaacagg cttcggacag     2820

tgcccatgca atggcttggg ttgggatttt ggtttcttcc tttcctcgtg aaggataaga     2880

gaaacaggcc cggggggacc aggatgacac ctccatttct ctccaggaag ttttgagttt     2940

ctctccaccg tgacacaatc ctcaaacatg gaagatgaaa ggggagggga tgtcaggccc     3000

agagaagcaa gtggctttca acacacaaca gcagatggca ccaacgggac cccctggccc     3060

tgcctcatcc accaatctct aagccaaacc cctaaactca ggagtcaacg tgtttacctc     3120

ttctatgcaa gccttgctag acagccaggt tagcctttgc cctgtcaccc ccgaatcatg     3180

acccacccag tgtctttcga ggtgggtttg taccttcctt aagccaggaa agggattcat     3240

ggcgtcggaa atgatctggc tgaatccgtg gtggcaccga gaccaaactc attcaccaaa     3300

tgatgccact tcccagaggc agagcctgag tcactggtca cccttaatat ttattaagtg     3360

cctgagacac ccggttacct tggccgtgag gacacgtggc ctgcacccag gtgtggctgt     3420

caggacacca gcctggtgcc catcctcccg acccctaccc acttccattc ccgtggtctc     3480

cttgcacttt ctcagttcag agttgtacac tgtgtacatt tggcatttgt gttattattt     3540

tgcactgttt tctgtcgtgt gtgttgggat gggatcccag gccagggaaa gcccgtgtca     3600

atgaatgccg gggacagaga ggggcaggtt gaccgggact tcaaagccgt gatcgtgaat     3660

atcgagaact gccattgtcg tctttatgtc cgcccaccta gtgcttccac ttctatgcaa     3720

atgcctccaa gccattcact tccccaatct tgtcgttgat gggtatgtgt ttaaaacatg     3780

cacggtgagg ccgggcgcag tggctcacgc ctgtaatccc agcactttgg gaggccgagg     3840

cgggtggatc atgaggtcag gagatcgaga ccatcctggc taacacgtga aaccccgtct     3900

ctactaaaaa tacaaaaaat tagccgggcg tggtggcggg cacctgtagt cccagctact     3960

cgggaggctg aggcaggaga atggtgtgaa cccgggaagc ggagcttgca gtgagccgag     4020

attgcgccac tgcagtccgc agtctggcct gggcgacaga gcgagactcc gtctcaaaaa     4080

aaaaaaacaa aaaaaaacca tgcatggtgc atcagcagcc catggcctct ggccaggcat     4140

ggcgaggctg aggtgggagg atggtttgag ctcaggcatt tgaggctgtc gtgagctatg     4200

attatgccac tgctttccag cctgggcaac atagtaagac cccatctctt aaaaaatgaa     4260

tttggccaga cacaggtgcc tcacgcctgt aatcccagca ctttgggagg ctgagctgga     4320

tcacttgagt tcaggagttg gagaccaggc ctgagcaaca aagcgagatc ccatctctac     4380

aaaaaccaaa aagttaaaaa tcagctgggt acggtggcac gtgcctgtga tcccagctac     4440

ttgggaggct gaggcaggag gatcgcctga gcccaggagg tggaggttgc agtgagccat     4500

gatcgagcca ctgcactcca gcctgggcaa cagatgaaga ccctatttca gaaatacaac     4560

tataaaaaaa taaataaatc ctccagtctg gatcgtttga cgggacttca ggttctttct     4620

gaaatcgccg tgttactgtt gcactgatgt ccggagagac agtgacagcc tccgtcagac     4680

tcccgcgtga agatgtcaca agggattggc aattgtcccc agggacaaaa cactgtgtcc     4740

cccccagtgc agggaaccgt gataagcctt tctggtttcg gagcacgtaa atgcgtccct     4800

gtacagatag tggggatttt ttgttatgtt tgcactttgt atattggttg aaactgttat     4860

cacttatata tatatatata cacacatata tataaaatct atttattttt gcaaaccctg     4920

gttgctgtat ttgttcagtg actattctcg gggccctgtg tagggggtta ttgcctctga     4980

aatgcctctt ctttatgtac aaagattatt tgcacgaact ggactgtgtg caacgctttt     5040

tgggagaatg atgtccccgt tgtatgtatg agtggcttct gggagatggg tgtcactttt     5100

taaaccactg tatagaaggt ttttgtagcc tgaatgtctt actgtgatca attaaatttc     5160

ttaaatgaac caa                                                        5173


<210>  2
<211>  2583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  2
atggggccct ggggctggaa attgcgctgg accgtcgcct tgctcctcgc cgcggcgggg       60

actgcagtgg gcgacagatg cgaaagaaac gagttccagt gccaagacgg gaaatgcatc      120

tcctacaagt gggtctgcga tggcagcgct gagtgccagg atggctctga tgagtcccag      180

gagacgtgct tgtctgtcac ctgcaaatcc ggggacttca gctgtggggg ccgtgtcaac      240

cgctgcattc ctcagttctg gaggtgcgat ggccaagtgg actgcgacaa cggctcagac      300

gagcaaggct gtccccccaa gacgtgctcc caggacgagt ttcgctgcca cgatgggaag      360

tgcatctctc ggcagttcgt ctgtgactca gaccgggact gcttggacgg ctcagacgag      420

gcctcctgcc cggtgctcac ctgtggtccc gccagcttcc agtgcaacag ctccacctgc      480

atcccccagc tgtgggcctg cgacaacgac cccgactgcg aagatggctc ggatgagtgg      540

ccgcagcgct gtaggggtct ttacgtgttc caaggggaca gtagcccctg ctcggccttc      600

gagttccact gcctaagtgg cgagtgcatc cactccagct ggcgctgtga tggtggcccc      660

gactgcaagg acaaatctga cgaggaaaac tgcgctgtgg ccacctgtcg ccctgacgaa      720

ttccagtgct ctgatggaaa ctgcatccat ggcagccggc agtgtgaccg ggaatatgac      780

tgcaaggaca tgagcgatga agttggctgc gttaatgtga cactctgcga gggacccaac      840

aagttcaagt gtcacagcgg cgaatgcatc accctggaca aagtctgcaa catggctaga      900

gactgccggg actggtcaga tgaacccatc aaagagtgcg ggaccaacga atgcttggac      960

aacaacggcg gctgttccca cgtctgcaat gaccttaaga tcggctacga gtgcctgtgc     1020

cccgacggct tccagctggt ggcccagcga agatgcgaag atatcgatga gtgtcaggat     1080

cccgacacct gcagccagct ctgcgtgaac ctggagggtg gctacaagtg ccagtgtgag     1140

gaaggcttcc agctggaccc ccacacgaag gcctgcaagg ctgtgggctc catcgcctac     1200

ctcttcttca ccaaccggca cgaggtcagg aagatgacgc tggaccggag cgagtacacc     1260

agcctcatcc ccaacctgag gaacgtggtc gctctggaca cggaggtggc cagcaataga     1320

atctactggt ctgacctgtc ccagagaatg atctgcagca cccagcttga cagagcccac     1380

ggcgtctctt cctatgacac cgtcatcagc agagacatcc aggcccccga cgggctggct     1440

gtggactgga tccacagcaa catctactgg accgactctg tcctgggcac tgtctctgtt     1500

gcggatacca agggcgtgaa gaggaaaacg ttattcaggg agaacggctc caagccaagg     1560

gccatcgtgg tggatcctgt tcatggcttc atgtactgga ctgactgggg aactcccgcc     1620

aagatcaaga aagggggcct gaatggtgtg gacatctact cgctggtgac tgaaaacatt     1680

cagtggccca atggcatcac cctagatctc ctcagtggcc gcctctactg ggttgactcc     1740

aaacttcact ccatctcaag catcgatgtc aacgggggca accggaagac catcttggag     1800

gatgaaaaga ggctggccca ccccttctcc ttggccgtct ttgaggacaa agtattttgg     1860

acagatatca tcaacgaagc cattttcagt gccaaccgcc tcacaggttc cgatgtcaac     1920

ttgttggctg aaaacctact gtccccagag gatatggttc tcttccacaa cctcacccag     1980

ccaagaggag tgaactggtg tgagaggacc accctgagca atggcggctg ccagtatctg     2040

tgcctccctg ccccgcagat caacccccac tcgcccaagt ttacctgcgc ctgcccggac     2100

ggcatgctgc tggccaggga catgaggagc tgcctcacag aggctgaggc tgcagtggcc     2160

acccaggaga catccaccgt caggctaaag gtcagctcca cagccgtaag gacacagcac     2220

acaaccaccc gacctgttcc cgacacctcc cggctgcctg gggccacccc tgggctcacc     2280

acggtggaga tagtgacaat gtctcaccaa gctctgggcg acgttgctgg cagaggaaat     2340

gagaagaagc ccagtagcgt gagggctctg tccattgtcc tccccatcgt gctcctcgtc     2400

ttcctttgcc tgggggtctt ccttctatgg aagaactggc ggcttaagaa catcaacagc     2460

atcaactttg acaaccccgt ctatcagaag accacagagg atgaggtcca catttgccac     2520

aaccaggacg gctacagcta cccctcgaga cagatggtca gtctggagga tgacgtggcg     2580

tga                                                                   2583


<210>  3
<211>  860
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  3

Met Gly Pro Trp Gly Trp Lys Leu Arg Trp Thr Val Ala Leu Leu Leu 
1               5                   10                  15      


Ala Ala Ala Gly Thr Ala Val Gly Asp Arg Cys Glu Arg Asn Glu Phe 
            20                  25                  30          


Gln Cys Gln Asp Gly Lys Cys Ile Ser Tyr Lys Trp Val Cys Asp Gly 
        35                  40                  45              


Ser Ala Glu Cys Gln Asp Gly Ser Asp Glu Ser Gln Glu Thr Cys Leu 
    50                  55                  60                  


Ser Val Thr Cys Lys Ser Gly Asp Phe Ser Cys Gly Gly Arg Val Asn 
65                  70                  75                  80  


Arg Cys Ile Pro Gln Phe Trp Arg Cys Asp Gly Gln Val Asp Cys Asp 
                85                  90                  95      


Asn Gly Ser Asp Glu Gln Gly Cys Pro Pro Lys Thr Cys Ser Gln Asp 
            100                 105                 110         


Glu Phe Arg Cys His Asp Gly Lys Cys Ile Ser Arg Gln Phe Val Cys 
        115                 120                 125             


Asp Ser Asp Arg Asp Cys Leu Asp Gly Ser Asp Glu Ala Ser Cys Pro 
    130                 135                 140                 


Val Leu Thr Cys Gly Pro Ala Ser Phe Gln Cys Asn Ser Ser Thr Cys 
145                 150                 155                 160 


Ile Pro Gln Leu Trp Ala Cys Asp Asn Asp Pro Asp Cys Glu Asp Gly 
                165                 170                 175     


Ser Asp Glu Trp Pro Gln Arg Cys Arg Gly Leu Tyr Val Phe Gln Gly 
            180                 185                 190         


Asp Ser Ser Pro Cys Ser Ala Phe Glu Phe His Cys Leu Ser Gly Glu 
        195                 200                 205             


Cys Ile His Ser Ser Trp Arg Cys Asp Gly Gly Pro Asp Cys Lys Asp 
    210                 215                 220                 


Lys Ser Asp Glu Glu Asn Cys Ala Val Ala Thr Cys Arg Pro Asp Glu 
225                 230                 235                 240 


Phe Gln Cys Ser Asp Gly Asn Cys Ile His Gly Ser Arg Gln Cys Asp 
                245                 250                 255     


Arg Glu Tyr Asp Cys Lys Asp Met Ser Asp Glu Val Gly Cys Val Asn 
            260                 265                 270         


Val Thr Leu Cys Glu Gly Pro Asn Lys Phe Lys Cys His Ser Gly Glu 
        275                 280                 285             


Cys Ile Thr Leu Asp Lys Val Cys Asn Met Ala Arg Asp Cys Arg Asp 
    290                 295                 300                 


Trp Ser Asp Glu Pro Ile Lys Glu Cys Gly Thr Asn Glu Cys Leu Asp 
305                 310                 315                 320 


Asn Asn Gly Gly Cys Ser His Val Cys Asn Asp Leu Lys Ile Gly Tyr 
                325                 330                 335     


Glu Cys Leu Cys Pro Asp Gly Phe Gln Leu Val Ala Gln Arg Arg Cys 
            340                 345                 350         


Glu Asp Ile Asp Glu Cys Gln Asp Pro Asp Thr Cys Ser Gln Leu Cys 
        355                 360                 365             


Val Asn Leu Glu Gly Gly Tyr Lys Cys Gln Cys Glu Glu Gly Phe Gln 
    370                 375                 380                 


Leu Asp Pro His Thr Lys Ala Cys Lys Ala Val Gly Ser Ile Ala Tyr 
385                 390                 395                 400 


Leu Phe Phe Thr Asn Arg His Glu Val Arg Lys Met Thr Leu Asp Arg 
                405                 410                 415     


Ser Glu Tyr Thr Ser Leu Ile Pro Asn Leu Arg Asn Val Val Ala Leu 
            420                 425                 430         


Asp Thr Glu Val Ala Ser Asn Arg Ile Tyr Trp Ser Asp Leu Ser Gln 
        435                 440                 445             


Arg Met Ile Cys Ser Thr Gln Leu Asp Arg Ala His Gly Val Ser Ser 
    450                 455                 460                 


Tyr Asp Thr Val Ile Ser Arg Asp Ile Gln Ala Pro Asp Gly Leu Ala 
465                 470                 475                 480 


Val Asp Trp Ile His Ser Asn Ile Tyr Trp Thr Asp Ser Val Leu Gly 
                485                 490                 495     


Thr Val Ser Val Ala Asp Thr Lys Gly Val Lys Arg Lys Thr Leu Phe 
            500                 505                 510         


Arg Glu Asn Gly Ser Lys Pro Arg Ala Ile Val Val Asp Pro Val His 
        515                 520                 525             


Gly Phe Met Tyr Trp Thr Asp Trp Gly Thr Pro Ala Lys Ile Lys Lys 
    530                 535                 540                 


Gly Gly Leu Asn Gly Val Asp Ile Tyr Ser Leu Val Thr Glu Asn Ile 
545                 550                 555                 560 


Gln Trp Pro Asn Gly Ile Thr Leu Asp Leu Leu Ser Gly Arg Leu Tyr 
                565                 570                 575     


Trp Val Asp Ser Lys Leu His Ser Ile Ser Ser Ile Asp Val Asn Gly 
            580                 585                 590         


Gly Asn Arg Lys Thr Ile Leu Glu Asp Glu Lys Arg Leu Ala His Pro 
        595                 600                 605             


Phe Ser Leu Ala Val Phe Glu Asp Lys Val Phe Trp Thr Asp Ile Ile 
    610                 615                 620                 


Asn Glu Ala Ile Phe Ser Ala Asn Arg Leu Thr Gly Ser Asp Val Asn 
625                 630                 635                 640 


Leu Leu Ala Glu Asn Leu Leu Ser Pro Glu Asp Met Val Leu Phe His 
                645                 650                 655     


Asn Leu Thr Gln Pro Arg Gly Val Asn Trp Cys Glu Arg Thr Thr Leu 
            660                 665                 670         


Ser Asn Gly Gly Cys Gln Tyr Leu Cys Leu Pro Ala Pro Gln Ile Asn 
        675                 680                 685             


Pro His Ser Pro Lys Phe Thr Cys Ala Cys Pro Asp Gly Met Leu Leu 
    690                 695                 700                 


Ala Arg Asp Met Arg Ser Cys Leu Thr Glu Ala Glu Ala Ala Val Ala 
705                 710                 715                 720 


Thr Gln Glu Thr Ser Thr Val Arg Leu Lys Val Ser Ser Thr Ala Val 
                725                 730                 735     


Arg Thr Gln His Thr Thr Thr Arg Pro Val Pro Asp Thr Ser Arg Leu 
            740                 745                 750         


Pro Gly Ala Thr Pro Gly Leu Thr Thr Val Glu Ile Val Thr Met Ser 
        755                 760                 765             


His Gln Ala Leu Gly Asp Val Ala Gly Arg Gly Asn Glu Lys Lys Pro 
    770                 775                 780                 


Ser Ser Val Arg Ala Leu Ser Ile Val Leu Pro Ile Val Leu Leu Val 
785                 790                 795                 800 


Phe Leu Cys Leu Gly Val Phe Leu Leu Trp Lys Asn Trp Arg Leu Lys 
                805                 810                 815     


Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro Val Tyr Gln Lys Thr Thr 
            820                 825                 830         


Glu Asp Glu Val His Ile Cys His Asn Gln Asp Gly Tyr Ser Tyr Pro 
        835                 840                 845             


Ser Arg Gln Met Val Ser Leu Glu Asp Asp Val Ala 
    850                 855                 860 


<210>  4
<211>  9213
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  4
accccgctct ccggccgccg ccggtgcggg tgctccgcta ccggctcctc tccgttctgt       60

gctctcttct gctctcggct ccccaccccc tctcccttcc ctcctctccc cttgcctccc      120

ctcctctgca gcgcctgcat tattttctgc ccgcaggctc ggcttgcact gctgctgcag      180

cccggggagg tggctgggtg ggtggggagg agactgtgca agttgtaggg gagggggtgc      240

cctcttcttc cccgctccct tcccccgcca actccttccc ctccttctcc ccctttcccc      300

tccccgcccc caccttcttc ctcctttcgg aaggactggt aacttgtcgt gcggagcgaa      360

cggcggcggc ggcggcggcg gcggcaccat ccaggcgggc accatgggca cgtccgcgct      420

ctgggcgctc tggctgctgc tcgcgctgtg ctgggcgccc cgggagagcg gcgccaccgg      480

aaccgggaga aaagccaaat gtgaaccctc ccaattccag tgcacaaatg gtcgctgtat      540

tacgctgttg tggaaatgtg atggggatga agactgtgtt gacggcagtg atgaaaagaa      600

ctgtgtaaag aagacgtgtg ctgaatctga cttcgtgtgc aacaatggcc agtgtgttcc      660

cagccgatgg aagtgtgatg gagatcctga ctgcgaagat ggttcagatg aaagcccaga      720

acagtgccat atgagaacat gccgcataca tgaaatcagc tgtggcgccc attctactca      780

gtgtatccca gtgtcctgga gatgtgatgg tgaaaatgat tgtgacagtg gagaagatga      840

agaaaactgt ggcaatataa catgtagtcc cgacgagttc acctgctcca gtggccgctg      900

catctccagg aactttgtat gcaatggcca ggatgactgc agcgatggca gtgatgagct      960

ggactgtgcc ccgccaacct gtggcgccca tgagttccag tgcagcacct cctcctgcat     1020

ccccatcagc tgggtatgcg acgatgatgc agactgctcc gaccaatctg atgagtccct     1080

ggagcagtgt ggccgtcagc cagtcataca caccaagtgt ccagccagcg aaatccagtg     1140

cggctctggc gagtgcatcc ataagaagtg gcgatgtgat ggggaccctg actgcaagga     1200

tggcagtgat gaggtcaact gtccctctcg aacttgccga cctgaccaat ttgaatgtga     1260

ggatggcagc tgcatccatg gcagcaggca gtgtaatggt atccgagact gtgtcgatgg     1320

ttccgatgaa gtcaactgca aaaatgtcaa tcagtgcttg ggccctggaa aattcaagtg     1380

cagaagtgga gaatgcatag atatcagcaa agtatgtaac caggagcagg actgcaggga     1440

ctggagtgat gagcccctga aagagtgtca tataaacgaa tgcttggtaa ataatggtgg     1500

atgttctcat atctgcaaag acctagttat aggctacgag tgtgactgtg cagctgggtt     1560

tgaactgata gataggaaaa cctgtggaga tattgatgaa tgccaaaatc caggaatctg     1620

cagtcaaatt tgtatcaact taaaaggcgg ttacaagtgt gaatgtagtc gtggctatca     1680

aatggatctt gctactggcg tgtgcaaggc agtaggcaaa gagccaagtc tgatcttcac     1740

taatcgaaga gacatcagga agattggctt agagaggaaa gaatatatcc aactagttga     1800

acagctaaga aacactgtgg ctctcgatgc tgacattgct gcccagaaac tattctgggc     1860

cgatctaagc caaaaggcta tcttcagtgc ctcaattgat gacaaggttg gtagacatgt     1920

taaaatgatc gacaatgtct ataatcctgc agccattgct gttgattggg tgtacaagac     1980

catctactgg actgatgcgg cttctaagac tatttcagta gctaccctag atggaaccaa     2040

gaggaagttc ctgtttaact ctgacttgcg agagcctgcc tccatagctg tggacccact     2100

gtctggcttt gtttactggt cagactgggg tgaaccagct aaaatagaaa aagcaggaat     2160

gaatggattc gatagacgtc cactggtgac agcggatatc cagtggccta acggaattac     2220

acttgacctt ataaaaagtc gcctctattg gcttgattct aagttgcaca tgttatccag     2280

cgtggacttg aatggccaag atcgtaggat agtactaaag tctctggagt tcctagctca     2340

tcctcttgca ctaacaatat ttgaggatcg tgtctactgg atagatgggg aaaatgaagc     2400

agtctatggt gccaataaat tcactggatc agagctagcc actctagtca acaacctgaa     2460

tgatgcccaa gacatcattg tctatcatga acttgtacag ccatcaggta aaaattggtg     2520

tgaagaagac atggagaatg gaggatgtga atacctatgc ctgccagcac cacagattaa     2580

tgatcactct ccaaaatata cctgttcctg tcccagtggg tacaatgtag aggaaaatgg     2640

ccgagactgt caaagtactg caactactgt gacttacagt gagacaaaag atacgaacac     2700

aacagaaatt tcagcaacta gtggactagt tcctggaggg atcaatgtga ccacagcagt     2760

atcagaggtc agtgttcccc caaaagggac ttctgccgca tgggccattc ttcctctctt     2820

gctcttagtg atggcagcag taggtggcta cttgatgtgg cggaattggc aacacaagaa     2880

catgaaaagc atgaactttg acaatcctgt gtacttgaaa accactgaag aggacctctc     2940

catagacatt ggtagacaca gtgcttctgt tggacacacg tacccagcaa tatcagttgt     3000

aagcacagat gatgatctag cttgacttct gtgacaaatg ttgacctttg aggtctaaac     3060

aaataatacc cccgtcggaa tggtaaccga gccagcagct gaagtctctt tttcttcctc     3120

tcggctggaa gaacatcaag atacctttgc gtggatcaag cttgtgtact tgaccgtttt     3180

tatattactt ttgtaaatat tcttgtccac attctacttc agctttggat gtggttaccg     3240

agtatctgta acccttgaat ttctagacag tattgccacc tctggccaaa tatgcacttt     3300

ccctagaaag ccatattcca gcagtgaaac ttgtgctata gtgtatacca cctgtacata     3360

cattgtatag gccatctgta aatatcccag agaacaatca ctattcttaa gcactttgaa     3420

aatatttcta tgtaaattat tgtaaacttt ttcaatggtt gggacaatgg caataggaca     3480

aaacgggtta ctaagatgaa attgccaaaa aaatttataa actaattttg tacgtatgaa     3540

tgatatcttt gacctcaatg gaggtttgca aagactgagt gttcaaacta ctgtacattt     3600

tttttcaagt gctaaaaaat taaaccaagc agcttaacca tggtttgtgc ctgttcctct     3660

aggatgaact cctatcctga gtagtaccaa gtgttctaac taaatgtgtg agctgtagtt     3720

cttgatgttg tataactaag cctgtaattg ggctggtttc tcttacaccc tagcacagtt     3780

aaaaaatgaa gtactgttta acatttgctc ccgaaatatt tcttactgtg taaaagaagc     3840

tagcttagtc tgtacctaga attcctcttg gttagaggag tgagtttctt ttttttccat     3900

taacttgttt cctgatcgag aaacacgtgc taagatttct atgaattctg cttctttata     3960

gttaagtctc tgttttccat gttctgtcat ttatataggt caaggacaag tgccttctaa     4020

ggcatggata agggctttct tcttatgaaa gtctagactg tcttactgtg aagatggcca     4080

gggaggatag caagcaatgg cattcttgaa cagtctaagg caggtttctc agtgtggtcc     4140

tgagaacaga agcatctgca tcacctggga atgtattaga aatgcaagtt cccagcccca     4200

tcccagacct actgaatcag aaactctggg ggcgagggct gaaacctgct ttcataagcc     4260

cttcaggcga tactgatgta aactaaagct taaaaaccac cgttttactg tgacttcatg     4320

aagaatataa ttgcaatatc acctaaattt ttatcctggc tgggatgggg cagattctta     4380

ctatggacaa tttctggaac ttacagtatg aagagcagat gaggagtttg agacaaagaa     4440

aaaattgtac agggagttta gtgaattttc catcaggttg gccattactt tctttctcta     4500

aagtctcagg atgtctggaa gcaaggaaag acaaaagact tgaagcaccg ggtgcatgct     4560

gtgtgtcaca agtgaggtgg agagttggct gtggaaggta cagcaattcc tctggaatta     4620

aatgaccgac caacacagta ccaagaggat gaagagaaga tgttttgcgt tgctacgtga     4680

atcagtggat gactcatatt tcacttgcat atgaaatata aggcagttaa catcttgttt     4740

gtggcttaag caaggacatt aatcctacta gatgaagggg aagttggttc tgttgtctta     4800

agggatgccc ccttgtgatt ttggtcaact gaatgaaaaa gaaaagatag ccttggactt     4860

ttttttcatg ggaggtttgg aggtcaagca tgtagaagga aaaggctgta gtcatgaata     4920

tagaactgtc tgctctccac cttttcctca ctctacattt agtcatcaca ctgaacagga     4980

tgtggcctgc tgacagtgag tagctgaagt gcctgtttgg taagtaggtt agcattcatc     5040

atgaactctg aaagccattt cagagtttgg ctgctgctct gaccctgctg tggtacaaaa     5100

aacatggatt tttttttttt taactggagt aataccaaat tccctttaga agcttgaagt     5160

ttgatactat tgctttcccc attataagga ttatacagta ttaattaatt ataaggccca     5220

aagtttgttt tggcaaataa agtattattc tctatcatca tcttttgaat tcctgtccct     5280

agtatgttct ttcatgttct gggtaaaatt tccaaccctc aaagagtcta aaacgtctca     5340

ttttttttta ccacgtcctc cccagtaaga agccaaggta caactcattg tacctacgag     5400

gtacaaactc atttgtagaa acaaagtaac tagatattcc tattgaaata agaatagata     5460

tattggtggg ccaggcatgg tggctcacgc ctataatccc agcactttgg aaggccaagg     5520

caggaggatc acttgaggcc aggagttcga gaccagcctg agcaacatgg tgagaccctg     5580

tctctacaaa aaaaaaattt ataaaaataa aagaaaaaaa tagttatatg actaaactac     5640

tagtcaatac agcttgcaat aatagtgcat gaatgataac aggcctcggc tttatcaccc     5700

aaaaaataac ttgaattcta tgtgaaatgt gttaggataa gtttgctctg tctctagagt     5760

tcaatgtaga agataattaa gaggtaaaat atgaagctta tcatacacta aaggagaata     5820

tttggagtta gatgagcctg tcacacaaag tgaaagtgga ccctccagaa attttaggaa     5880

ttgccacaaa gattgatgat agatgaataa acagatttgt ggcctctggt aaagaaatcc     5940

agccaagttc ctctgtccaa atttttaagt gccctttgca agctaatcta tttggcaaaa     6000

aaatagtccc agttgttcaa ctagctccct taaaacattc tagtaggtgt tttaaagcct     6060

aggtatcgct gcctctttag ttcttgatga atacaaggca aaaaaaaaaa aaaaaaaaaa     6120

aaaaaaattg aggctttcac tttggcattt gcttctgttc cttgtatctg tggaagtcaa     6180

gtagcccttc tcaaaaatga gaagccaagc tttaaatagc aaactacagg gtattaaaag     6240

actaactctt cagttaagaa cactgtagaa atggtagacc aacttaaagt ctacctttta     6300

acaatcttta ccccaaacct aaagattcta ggggtcactt atctctatta cgtaatctaa     6360

ctggaataat ttcctagaat tcttactagt gaaatcttac ccaagtaaaa caatttatta     6420

ttttgaatcc aaatgaaagc tatactgttt gctttcaatg gtggcaaaaa cttgcaaaaa     6480

gcagatatac ttttgctaat ttaagttgaa gtactatgaa tacaacctgc taatcttgat     6540

ccccaaatct gagcccttca gtttcataat tgttttatcc tgaacgtagt tgtgacatag     6600

acatttctca aaagggtctg atacatcaaa ctcctaacaa gtaggagcag caactagcta     6660

aagagtagaa agaagcttcc cttattgtgg gtgatgaggc ggtgcctaaa aaccacatat     6720

atataatccc ctgggtatta catattctgc aagccctgtt agtggggaga tggtagtggc     6780

aatagcagcg atagttgcgt cagtgctaac tgctgctgct gcccgttctg ttggcggctg     6840

ctggccaagt gtgcacactt agccctggtt gaggtgcatt gtctgctgtc gtctgttaag     6900

catctaaccg gagtgggagg gcacatcaag cgatttcact ctcttaaaga aaaggttttt     6960

aggtattttt ggtattatat agtctctaag gccagaaggg gcttataatg acttctcttc     7020

tagaattgta atactaaaaa actactcgag taaatatcct aacaagtatg atttttcttg     7080

ggaaaactaa aaattgtaca tccatgcttc agccatatca tgggcctaaa ctatgagagt     7140

tcagaaatat ataaaagtac aaaaatcttc aaaggtactt atttccaaat atggagggaa     7200

tgaatctgaa gagggaacaa tggcgttttt cgaacttatt tctctctaat ccagcctgga     7260

ggatttttag ccgaaacagt tgcatgtgaa ggattatcag ccatctttgc atatcccttt     7320

cacatctacc ttcacacagg aaagctgaat gcattttacc agtgaggctc tagatatgaa     7380

acttagggat ccatagataa ataagctact aacaaactga taacagtggt gttccatctc     7440

tctatcatgt ctcctgagtc cgtttcacgt ttttgagcct ggctaatgag aaaaagaaca     7500

aagtaggacc atgacccagt gttctcctgt aaatctcact gtaaaaatct caatgcaaaa     7560

acactgagac aggagtgaga ccagctgcgg gtggggagtt tgtgctccgc aggttacctc     7620

atggcatatc aaaaatggct tttttcttca ctgcgctcaa ggaaaaagtc agatgggtga     7680

caaggtggtt ctgtttagaa gcagcaggca atgtagttaa cagcatagac ttccgtgtct     7740

tgtgtgtggt accttgggca agttactaac tccctctgta aagtagagac gatggggact     7800

gtctcactgt gacaaggtaa gatttaagtg agatgcacac aaaaagctca gcacagtgtc     7860

tggcatctaa tatgtgcagg gcagatgtca ctactgaata tcacatcaat gctagggctg     7920

tatttactgt cacacacagg caccggtaag tgactttacc ggtgaaagtc acaggtacct     7980

ttatctatga tgaatgtaat gtgttagatg gtgaccgaag tgttctccac tacacctgtc     8040

tgaagagatc taagtctgat atttaaggag tgatagcatc ttgcatactt aagaaggctt     8100

aaaagactgc atggtttaaa ccctagaaac ataaatggaa tgtttctgcc tcagttcttt     8160

tgactacctc ctaggacatg gaaacaaata tttgggagcc tgcatagtct ttagatggct     8220

gccaaagcac ttaaaatctc ctttaaattc ttaccatatg cttacttttg tactaagtaa     8280

gtgctcccaa gtcttttact tgctcttcac agcaacccta ataggtatct ccattttaca     8340

taggtaaaaa ctgaggctac aaacaatcta tggttccaaa tcctatgtgc ttactgccgt     8400

cttctcttag aaggggatgc agtactgtac aaagattgag ctggatgtcg cattgcatgt     8460

ttgctgagtc ctcctcattg ctgatgttag gatccttcaa cagtttctca gatgccagct     8520

atggctggca tccagtatgg tggtgtaatg gaagtgtact actagcacta ctacatcagg     8580

tcagcacaga ttaactcagt tacgtgttat accttcaaga cgctagacat tccagaatta     8640

ttttccttgg ccatccaagt gaagtagaag tagattgttg gattgcaaag aaaatgataa     8700

agattcccta aaggaattta taagcaggca acttcattcc tatgtataag atattgggag     8760

aaaacaaact gtaccacaac aaatcttaag tttcaaggct ctcctatagg gagaaacatg     8820

gccaaaaaga caggaagaac tgtggcttgt aactcaatga tgctataact ccagcactgg     8880

atcttaagta ttctggaata taccagattg gtagaactac cagacttggg tatttctcag     8940

ttaacacaca tgcaaggagg aagagagttt ttttgaacaa aatgactggc tttgacaaaa     9000

ctatcttgct ctttttaaat gtcacttgat actagaatgc gatttaaaag catgtaatgc     9060

ctcaggagtc cggcatatac aaccaaatta tcatgctcag gatcttcaga attctaaagg     9120

cacatgttag aatgcagagt cctgatgacc tgtcaataaa ctttttttta ctaatgaact     9180

gtacatttaa ataaaagttt atttttggga taa                                  9213


<210>  5
<211>  2622
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  5
atgggaactt ctgcactctg ggcattgtgg cttctgttgg ctctgtgctg ggcgccacga       60

gaaagcggag ctacaggtac tggaaggaag gccaagtgtg aacccagtca attccagtgc      120

acaaacggca ggtgtattac tctgctctgg aagtgcgacg gtgacgagga ttgtgtggac      180

ggttcagatg agaagaattg cgtcaagaag acctgcgctg aatccgattt cgtctgcaac      240

aacggccagt gtgtgccaag ccggtggaaa tgtgacggcg atcccgattg cgaagatggc      300

agcgacgagt ccccagaaca gtgccacatg aggacctgca gaattcatga gatcagctgc      360

ggagcccact ctactcagtg cattcctgtc agctggcgat gcgatggcga aaatgactgc      420

gacagcggcg aagacgaaga gaactgcggg aacatcacct gttccccgga cgaattcaca      480

tgttcctccg gacgctgtat ttccagaaac ttcgtttgca acggccagga tgactgcagc      540

gatgggtctg acgagctgga ttgcgctcct cctacatgtg gtgcacacga atttcagtgc      600

tctaccagta gctgtatacc tattagttgg gtctgtgacg atgatgccga ctgtagtgat      660

cagagtgacg agtctctgga acagtgcggc aggcaaccgg tcattcatac taaatgtccc      720

gcgagtgaga ttcagtgcgg gtcaggcgag tgcattcata agaagtggag atgcgatggc      780

gatcctgact gcaaagacgg atcagacgaa gtgaattgtc cttcccggac atgtagaccc      840

gaccagtttg aatgtgaaga tggaagctgt atacacggga gccgccagtg taacggaatc      900

agagactgcg tggatggatc tgatgaagtc aattgtaaga acgtgaatca atgccttggc      960

cccggaaaat tcaaatgcag aagtggggaa tgtattgaca tatcaaaggt ttgcaaccag     1020

gaacaagatt gccgggattg gtcagatgag ccacttaagg aatgccatat caacgaatgt     1080

ttggtgaaca acgggggctg ttcccatatc tgtaaagacc tggtaatagg ttacgagtgt     1140

gattgcgctg ccggatttga attgatcgac aggaagacct gcggtgacat tgatgagtgt     1200

cagaatccag gcatctgttc ccagatctgt attaacctca aaggaggata taaatgtgag     1260

tgctctaggg gatatcagat ggacctggca acaggagtgt gcaaggctgt tgggaaagag     1320

ccctctctga tttttaccaa cagacgagac atacgcaaga tcggactgga acggaaggag     1380

tacatccagc tcgtagagca gcttcgaaac actgtcgcgc tggacgctga catagcagcc     1440

cagaagctgt tttgggctga tctgtcccag aaggcaatct tcagcgctag catcgacgac     1500

aaagtggggc gccacgtaaa gatgattgat aacgtgtata acccagccgc gatcgcggtt     1560

gactgggtgt ataagacaat ctactggacc gatgccgcct caaaaactat ctccgtggct     1620

accttggatg gaacgaaacg caagttcttg ttcaacagtg atctcagaga acccgcatcc     1680

atagccgttg accccctctc cggctttgtg tattggtcag attggggcga gcctgcaaag     1740

atagagaagg caggcatgaa cggattcgac cggcgacctt tggttaccgc agacattcag     1800

tggccaaacg gcattacact ggacctgatc aagagcaggc tgtactggct ggactctaaa     1860

ctccacatgc tttcttccgt agacttgaat ggccaggaca ggaggatcgt gctgaaaagc     1920

ctcgagtttc tggcacaccc gctggcactg accatctttg aagatcgggt ctactggatt     1980

gatggcgaaa acgaagcggt gtacggggcc aataagttca caggctcaga gctggccacc     2040

ctggtcaata acctgaacga cgcacaggat atcatagttt atcacgagct cgtgcagcca     2100

agtgggaaga attggtgtga ggaggacatg gaaaatggcg gatgtgagta cctctgtctc     2160

ccagcaccac agatcaacga tcattcacca aagtacacgt gctcctgtcc ttccggatat     2220

aatgtggagg agaatggtag agactgccag tccacagcta ctaccgtaac gtactctgag     2280

acaaaggaca ccaacaccac cgaaatttct gctacctccg gtttggtgcc agggggcatc     2340

aacgttacca ctgccgtgtc tgaagtgtcc gtcccaccca agggaacatc agcggcatgg     2400

gctattctgc cgctgctgct gcttgttatg gcagctgttg gcggatattt gatgtggcgg     2460

aattggcagc acaaaaatat gaagtcaatg aacttcgata accctgtcta cctcaaaacc     2520

acggaggagg atctctctat tgatattggt aggcatagcg cttccgtggg tcatacttac     2580

cccgccatca gcgtggtgtc aaccgatgat gacctcgctt ga                        2622


<210>  6
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  6

Met Gly Thr Ser Ala Leu Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Glu Ser Gly Ala Thr Gly Thr Gly Arg Lys Ala Lys 
            20                  25                  30          


Cys Glu Pro Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Val Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Asn 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Ser Arg Trp Lys Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile His Glu Ile Ser Cys Gly Ala His Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Ser Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Pro Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Ile Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Ser Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Ile 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Ala Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Ile Ser Lys 
                325                 330                 335     


Val Cys Asn Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Val Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Thr Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Ala Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Ile Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Glu Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Ser Gly Tyr Asn Val Glu Glu Asn Gly Arg Asp Cys Gln Ser Thr 
            740                 745                 750         


Ala Thr Thr Val Thr Tyr Ser Glu Thr Lys Asp Thr Asn Thr Thr Glu 
        755                 760                 765             


Ile Ser Ala Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210>  7
<211>  2622
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  7
atgggtactt cagcaagatg ggcactctgg ttgctcttgg cattgtgttg ggcaccaaga       60

gatagtggag ccacagcttc cggcaaaaag gcaaagtgtg acagctcaca atttcagtgc      120

actaacggcc ggtgcataac cctcctgtgg aagtgtgatg gggacgaaga ttgcgctgat      180

ggctcagatg agaagaattg tgtgaagaag acctgtgctg agtctgattt cgtgtgtaaa      240

aacggccaat gtgtgccgaa taggtggcag tgcgacggag accccgattg cgaggatgga      300

tctgacgaga gtccggaaca gtgccatatg cgcacctgcc ggatcaacga gatctcttgt      360

ggcgctaggt ccacccaatg tatacctgta tcttggcgct gcgatgggga aaatgactgc      420

gacaatggag aggacgagga gaactgcggg aatataacat gtagcgccga tgagttcaca      480

tgctctagcg gaaggtgtgt gagccgcaat tttgtctgta acgggcaaga tgactgtgat      540

gacggatcag acgaattgga ttgtgctcca ccgacttgtg gggctcacga attccagtgt      600

agcacaagct cctgtattcc actgagctgg gtgtgcgacg acgatgctga ctgctctgat      660

cagagcgacg agtcattgga acagtgtggg cgccagccag tgattcacac taagtgcccc      720

acatctgaaa ttcaatgtgg gagtggagaa tgcattcata agaagtggag atgcgacggg      780

gacccagact gtaaagacgg gtcagatgag gtgaattgcc caagccgaac atgtcgacca      840

gaccagttcg agtgtgagga tggctcttgc atccacggga gtaggcagtg caatggaatc      900

cgggattgtg tggacggcag cgacgaagtc aactgcaaaa acgtcaatca gtgtctgggc      960

cctggaaagt tcaaatgccg gtccggagag tgtattgaca tgtccaaagt gtgcgatcag     1020

gagcaggatt gtagggattg gtccgacgaa cctctgaaag agtgtcacat caatgaatgt     1080

ctcgtaaaca acggaggctg ttcccacatt tgcaaagatc tcgtaattgg ttatgaatgc     1140

gattgtgctg ctggattcga gttgatcgat cggaagacct gcggggatat tgatgaatgt     1200

cagaatcccg gtatctgctc ccagatttgc attaatctta aaggcgggta caaatgcgag     1260

tgttcacggg ggtaccagat ggatctggct acaggggtgt gcaaggccgt tggcaaggaa     1320

cccagtttga tcttcaccaa ccgcagagat attaggaaga tcggcttgga acgcaaagag     1380

tacattcaac tggtggagca actcaggaac accgtggccc tggacgcaga tattgccgct     1440

cagaagctgt tctgggctga cttgtcccag aaggccatct tctctgccag catcgacgac     1500

aaggtaggca ggcattttaa gatgattgac aatgtgtaca acccagctgc catcgctgtg     1560

gactgggtgt acaagaccat ctattggacc gacgctgcta gcaaaacaat tagtgtggca     1620

actctggacg gagccaaacg gaagttcctc tttaactctg atttgcggga gccagcctcc     1680

atcgcagtgg atccactgtc agggttcgtt tattggtccg attggggcga gcctgctaag     1740

atagaaaagg ctggcatgaa cggttttgac cggcggccac tcgtcactga ggacatccaa     1800

tggcccaacg gtatcacact ggatctcgtg aagagccgcc tgtactggct cgatagcaag     1860

ctccacatgc tgtcctccgt ggaccttaac ggccaggacc gaaggatagt tctcaagtcc     1920

ctggagtttc tggcacatcc acttgccctt acgatatttg aagatagggt gtactggatc     1980

gatggagaaa atgaagccgt ctacggagct aacaaattta ctgggtcaga gttggctact     2040

cttgttaata acctgaacga cgcccaagac attatcgtgt accacgagct ggtgcagcca     2100

tccggcaaaa attggtgtga agatgatatg gaaaacggag gctgtgaata cctctgtctg     2160

cctgcccccc agatcaatga tcattcacca aagtatacat gcagttgccc taacggctat     2220

aacctcgagg aaaacgggag ggagtgccag agcacctcca ctccagtgac ttattcagag     2280

acaaaagata ttaatacaac ggatatattg aggacatccg gcttggttcc aggcggaatc     2340

aatgttacaa ctgcagtttc agaggttagt gtaccaccaa agggcacctc tgctgcctgg     2400

gcaatcctgc ctcttttgct ccttgttatg gccgcagtgg gaggttacct gatgtggcgc     2460

aattggcaac acaagaatat gaagtccatg aatttcgaca accctgtgta tttgaagaca     2520

acagaggagg acctgagtat tgatatcgga cgccattccg ctagtgtcgg ccatacctac     2580

ccggctataa gtgtggtgtc cactgacgac gacctggcct ga                        2622


<210>  8
<211>  873
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  8

Met Gly Thr Ser Ala Arg Trp Ala Leu Trp Leu Leu Leu Ala Leu Cys 
1               5                   10                  15      


Trp Ala Pro Arg Asp Ser Gly Ala Thr Ala Ser Gly Lys Lys Ala Lys 
            20                  25                  30          


Cys Asp Ser Ser Gln Phe Gln Cys Thr Asn Gly Arg Cys Ile Thr Leu 
        35                  40                  45              


Leu Trp Lys Cys Asp Gly Asp Glu Asp Cys Ala Asp Gly Ser Asp Glu 
    50                  55                  60                  


Lys Asn Cys Val Lys Lys Thr Cys Ala Glu Ser Asp Phe Val Cys Lys 
65                  70                  75                  80  


Asn Gly Gln Cys Val Pro Asn Arg Trp Gln Cys Asp Gly Asp Pro Asp 
                85                  90                  95      


Cys Glu Asp Gly Ser Asp Glu Ser Pro Glu Gln Cys His Met Arg Thr 
            100                 105                 110         


Cys Arg Ile Asn Glu Ile Ser Cys Gly Ala Arg Ser Thr Gln Cys Ile 
        115                 120                 125             


Pro Val Ser Trp Arg Cys Asp Gly Glu Asn Asp Cys Asp Asn Gly Glu 
    130                 135                 140                 


Asp Glu Glu Asn Cys Gly Asn Ile Thr Cys Ser Ala Asp Glu Phe Thr 
145                 150                 155                 160 


Cys Ser Ser Gly Arg Cys Val Ser Arg Asn Phe Val Cys Asn Gly Gln 
                165                 170                 175     


Asp Asp Cys Asp Asp Gly Ser Asp Glu Leu Asp Cys Ala Pro Pro Thr 
            180                 185                 190         


Cys Gly Ala His Glu Phe Gln Cys Ser Thr Ser Ser Cys Ile Pro Leu 
        195                 200                 205             


Ser Trp Val Cys Asp Asp Asp Ala Asp Cys Ser Asp Gln Ser Asp Glu 
    210                 215                 220                 


Ser Leu Glu Gln Cys Gly Arg Gln Pro Val Ile His Thr Lys Cys Pro 
225                 230                 235                 240 


Thr Ser Glu Ile Gln Cys Gly Ser Gly Glu Cys Ile His Lys Lys Trp 
                245                 250                 255     


Arg Cys Asp Gly Asp Pro Asp Cys Lys Asp Gly Ser Asp Glu Val Asn 
            260                 265                 270         


Cys Pro Ser Arg Thr Cys Arg Pro Asp Gln Phe Glu Cys Glu Asp Gly 
        275                 280                 285             


Ser Cys Ile His Gly Ser Arg Gln Cys Asn Gly Ile Arg Asp Cys Val 
    290                 295                 300                 


Asp Gly Ser Asp Glu Val Asn Cys Lys Asn Val Asn Gln Cys Leu Gly 
305                 310                 315                 320 


Pro Gly Lys Phe Lys Cys Arg Ser Gly Glu Cys Ile Asp Met Ser Lys 
                325                 330                 335     


Val Cys Asp Gln Glu Gln Asp Cys Arg Asp Trp Ser Asp Glu Pro Leu 
            340                 345                 350         


Lys Glu Cys His Ile Asn Glu Cys Leu Val Asn Asn Gly Gly Cys Ser 
        355                 360                 365             


His Ile Cys Lys Asp Leu Val Ile Gly Tyr Glu Cys Asp Cys Ala Ala 
    370                 375                 380                 


Gly Phe Glu Leu Ile Asp Arg Lys Thr Cys Gly Asp Ile Asp Glu Cys 
385                 390                 395                 400 


Gln Asn Pro Gly Ile Cys Ser Gln Ile Cys Ile Asn Leu Lys Gly Gly 
                405                 410                 415     


Tyr Lys Cys Glu Cys Ser Arg Gly Tyr Gln Met Asp Leu Ala Thr Gly 
            420                 425                 430         


Val Cys Lys Ala Val Gly Lys Glu Pro Ser Leu Ile Phe Thr Asn Arg 
        435                 440                 445             


Arg Asp Ile Arg Lys Ile Gly Leu Glu Arg Lys Glu Tyr Ile Gln Leu 
    450                 455                 460                 


Val Glu Gln Leu Arg Asn Thr Val Ala Leu Asp Ala Asp Ile Ala Ala 
465                 470                 475                 480 


Gln Lys Leu Phe Trp Ala Asp Leu Ser Gln Lys Ala Ile Phe Ser Ala 
                485                 490                 495     


Ser Ile Asp Asp Lys Val Gly Arg His Phe Lys Met Ile Asp Asn Val 
            500                 505                 510         


Tyr Asn Pro Ala Ala Ile Ala Val Asp Trp Val Tyr Lys Thr Ile Tyr 
        515                 520                 525             


Trp Thr Asp Ala Ala Ser Lys Thr Ile Ser Val Ala Thr Leu Asp Gly 
    530                 535                 540                 


Ala Lys Arg Lys Phe Leu Phe Asn Ser Asp Leu Arg Glu Pro Ala Ser 
545                 550                 555                 560 


Ile Ala Val Asp Pro Leu Ser Gly Phe Val Tyr Trp Ser Asp Trp Gly 
                565                 570                 575     


Glu Pro Ala Lys Ile Glu Lys Ala Gly Met Asn Gly Phe Asp Arg Arg 
            580                 585                 590         


Pro Leu Val Thr Glu Asp Ile Gln Trp Pro Asn Gly Ile Thr Leu Asp 
        595                 600                 605             


Leu Val Lys Ser Arg Leu Tyr Trp Leu Asp Ser Lys Leu His Met Leu 
    610                 615                 620                 


Ser Ser Val Asp Leu Asn Gly Gln Asp Arg Arg Ile Val Leu Lys Ser 
625                 630                 635                 640 


Leu Glu Phe Leu Ala His Pro Leu Ala Leu Thr Ile Phe Glu Asp Arg 
                645                 650                 655     


Val Tyr Trp Ile Asp Gly Glu Asn Glu Ala Val Tyr Gly Ala Asn Lys 
            660                 665                 670         


Phe Thr Gly Ser Glu Leu Ala Thr Leu Val Asn Asn Leu Asn Asp Ala 
        675                 680                 685             


Gln Asp Ile Ile Val Tyr His Glu Leu Val Gln Pro Ser Gly Lys Asn 
    690                 695                 700                 


Trp Cys Glu Asp Asp Met Glu Asn Gly Gly Cys Glu Tyr Leu Cys Leu 
705                 710                 715                 720 


Pro Ala Pro Gln Ile Asn Asp His Ser Pro Lys Tyr Thr Cys Ser Cys 
                725                 730                 735     


Pro Asn Gly Tyr Asn Leu Glu Glu Asn Gly Arg Glu Cys Gln Ser Thr 
            740                 745                 750         


Ser Thr Pro Val Thr Tyr Ser Glu Thr Lys Asp Ile Asn Thr Thr Asp 
        755                 760                 765             


Ile Leu Arg Thr Ser Gly Leu Val Pro Gly Gly Ile Asn Val Thr Thr 
    770                 775                 780                 


Ala Val Ser Glu Val Ser Val Pro Pro Lys Gly Thr Ser Ala Ala Trp 
785                 790                 795                 800 


Ala Ile Leu Pro Leu Leu Leu Leu Val Met Ala Ala Val Gly Gly Tyr 
                805                 810                 815     


Leu Met Trp Arg Asn Trp Gln His Lys Asn Met Lys Ser Met Asn Phe 
            820                 825                 830         


Asp Asn Pro Val Tyr Leu Lys Thr Thr Glu Glu Asp Leu Ser Ile Asp 
        835                 840                 845             


Ile Gly Arg His Ser Ala Ser Val Gly His Thr Tyr Pro Ala Ile Ser 
    850                 855                 860                 


Val Val Ser Thr Asp Asp Asp Leu Ala 
865                 870             


<210>  9
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  9

Met Ala Gln His Ser Asp Tyr Ser Asp Asp Glu Phe Cys Ala Asp Lys 
1               5                   10                  15      


Leu Ser Asn Tyr Ser Cys Asp Ser Asp Leu Glu Asn Ala Ser Thr Ser 
            20                  25                  30          


Asp Glu Asp Ser Ser Asp Asp Glu Val Met Val Arg Pro Arg Thr Leu 
        35                  40                  45              


Arg Arg Arg Arg Ile Ser Ser Ser Ser Ser Asp Ser Glu Ser Asp Ile 
    50                  55                  60                  


Glu Gly Gly Arg Glu Glu Trp Ser His Val Asp Asn Pro Pro Val Leu 
65                  70                  75                  80  


Glu Asp Phe Leu Gly His Gln Gly Leu Asn Thr Asp Ala Val Ile Asn 
                85                  90                  95      


Asn Ile Glu Asp Ala Val Lys Leu Phe Ile Gly Asp Asp Phe Phe Glu 
            100                 105                 110         


Phe Leu Val Glu Glu Ser Asn Arg Tyr Tyr Asn Gln Asn Arg Asn Asn 
        115                 120                 125             


Phe Lys Leu Ser Lys Lys Ser Leu Lys Trp Lys Asp Ile Thr Pro Gln 
    130                 135                 140                 


Glu Met Lys Lys Phe Leu Gly Leu Ile Val Leu Met Gly Gln Val Arg 
145                 150                 155                 160 


Lys Asp Arg Arg Asp Asp Tyr Trp Thr Thr Glu Pro Trp Thr Glu Thr 
                165                 170                 175     


Pro Tyr Phe Gly Lys Thr Met Thr Arg Asp Arg Phe Arg Gln Ile Trp 
            180                 185                 190         


Lys Ala Trp His Phe Asn Asn Asn Ala Asp Ile Val Asn Glu Ser Asp 
        195                 200                 205             


Arg Leu Cys Lys Val Arg Pro Val Leu Asp Tyr Phe Val Pro Lys Phe 
    210                 215                 220                 


Ile Asn Ile Tyr Lys Pro His Gln Gln Leu Ser Leu Asp Glu Gly Ile 
225                 230                 235                 240 


Val Pro Trp Arg Gly Arg Leu Phe Phe Arg Val Tyr Asn Ala Gly Lys 
                245                 250                 255     


Ile Val Lys Tyr Gly Ile Leu Val Arg Leu Leu Cys Glu Ser Asp Thr 
            260                 265                 270         


Gly Tyr Ile Cys Asn Met Glu Ile Tyr Cys Gly Glu Gly Lys Arg Leu 
        275                 280                 285             


Leu Glu Thr Ile Gln Thr Val Val Ser Pro Tyr Thr Asp Ser Trp Tyr 
    290                 295                 300                 


His Ile Tyr Met Asp Asn Tyr Tyr Asn Ser Val Ala Asn Cys Glu Ala 
305                 310                 315                 320 


Leu Met Lys Asn Lys Phe Arg Ile Cys Gly Thr Ile Arg Lys Asn Arg 
                325                 330                 335     


Gly Ile Pro Lys Asp Phe Gln Thr Ile Ser Leu Lys Lys Gly Glu Thr 
            340                 345                 350         


Lys Phe Ile Arg Lys Asn Asp Ile Leu Leu Gln Val Trp Gln Ser Lys 
        355                 360                 365             


Lys Pro Val Tyr Leu Ile Ser Ser Ile His Ser Ala Glu Met Glu Glu 
    370                 375                 380                 


Ser Gln Asn Ile Asp Arg Thr Ser Lys Lys Lys Ile Val Lys Pro Asn 
385                 390                 395                 400 


Ala Leu Ile Asp Tyr Asn Lys His Met Lys Gly Val Asp Arg Ala Asp 
                405                 410                 415     


Gln Tyr Leu Ser Tyr Tyr Ser Ile Leu Arg Arg Thr Val Lys Trp Thr 
            420                 425                 430         


Lys Arg Leu Ala Met Tyr Met Ile Asn Cys Ala Leu Phe Asn Ser Tyr 
        435                 440                 445             


Ala Val Tyr Lys Ser Val Arg Gln Arg Lys Met Gly Phe Lys Met Phe 
    450                 455                 460                 


Leu Lys Gln Thr Ala Ile His Trp Leu Thr Asp Asp Ile Pro Glu Asp 
465                 470                 475                 480 


Met Asp Ile Val Pro Asp Leu Gln Pro Val Pro Ser Thr Ser Gly Met 
                485                 490                 495     


Arg Ala Lys Pro Pro Thr Ser Asp Pro Pro Cys Arg Leu Ser Met Asp 
            500                 505                 510         


Met Arg Lys His Thr Leu Gln Ala Ile Val Gly Ser Gly Lys Lys Lys 
        515                 520                 525             


Asn Ile Leu Arg Arg Cys Arg Val Cys Ser Val His Lys Leu Arg Ser 
    530                 535                 540                 


Glu Thr Arg Tyr Met Cys Lys Phe Cys Asn Ile Pro Leu His Lys Gly 
545                 550                 555                 560 


Ala Cys Phe Glu Lys Tyr His Thr Leu Lys Asn Tyr 
                565                 570         


<210>  10
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  10
atggcccagc acagcgacta cagcgacgac gagttctgtg ccgataagct gagtaactac       60

agctgcgaca gcgacctgga aaacgccagc acatccgacg aggacagctc tgacgacgag      120

gtgatggtgc ggcccagaac cctgagacgg agaagaatca gcagctctag cagcgactct      180

gaatccgaca tcgagggcgg ccgggaagag tggagccacg tggacaaccc tcctgttctg      240

gaagattttc tgggccatca gggcctgaac accgacgccg tgatcaacaa catcgaggat      300

gccgtgaagc tgttcatagg agatgatttc tttgagttcc tggtcgagga atccaaccgc      360

tattacaacc agaatagaaa caacttcaag ctgagcaaga aaagcctgaa gtggaaggac      420

atcacccctc aggagatgaa aaagttcctg ggactgatcg ttctgatggg acaggtgcgg      480

aaggacagaa gggatgatta ctggacaacc gaaccttgga ccgagacccc ttactttggc      540

aagaccatga ccagagacag attcagacag atctggaaag cctggcactt caacaacaat      600

gctgatatcg tgaacgagtc tgatagactg tgtaaagtgc ggccagtgtt ggattacttc      660

gtgcctaagt tcatcaacat ctataagcct caccagcagc tgagcctgga tgaaggcatc      720

gtgccctggc ggggcagact gttcttcaga gtgtacaatg ctggcaagat cgtcaaatac      780

ggcatcctgg tgcgccttct gtgcgagagc gatacaggct acatctgtaa tatggaaatc      840

tactgcggcg agggcaaaag actgctggaa accatccaga ccgtcgtttc cccttatacc      900

gacagctggt accacatcta catggacaac tactacaatt ctgtggccaa ctgcgaggcc      960

ctgatgaaga acaagtttag aatctgcggc acaatcagaa aaaacagagg catccctaag     1020

gacttccaga ccatctctct gaagaagggc gaaaccaagt tcatcagaaa gaacgacatc     1080

ctgctccaag tgtggcagtc caagaaaccc gtgtacctga tcagcagcat ccatagcgcc     1140

gagatggaag aaagccagaa catcgacaga acaagcaaga agaagatcgt gaagcccaat     1200

gctctgatcg actacaacaa gcacatgaaa ggcgtggacc gggccgacca gtacctgtct     1260

tattactcta tcctgagaag aacagtgaaa tggaccaaga gactggccat gtacatgatc     1320

aattgcgccc tgttcaacag ctacgccgtg tacaagtccg tgcgacaaag aaaaatggga     1380

ttcaagatgt tcctgaagca gacagccatc cactggctga cagacgacat tcctgaggac     1440

atggacattg tgccagatct gcaacctgtg cccagcacct ctggtatgag agctaagcct     1500

cccaccagcg atcctccatg tagactgagc atggacatgc ggaagcacac cctgcaggcc     1560

atcgtcggca gcggcaagaa gaagaacatc cttagacggt gcagggtgtg cagcgtgcac     1620

aagctgcgga gcgagactcg gtacatgtgc aagttttgca acattcccct gcacaaggga     1680

gcctgcttcg agaagtacca caccctgaag aattactag                            1719


<210>  11
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  11
atggcccagc acagcgacta cagcgacgac gagttctgtg ccgataagct gagtaactac       60

agctgcgaca gcgacctgga aaacgccagc acatccgacg aggacagctc tgacgacgag      120

gtgatggtgc ggcccagaac cctgagacgg agaagaatca gcagctctag cagcgactct      180

gaatccgaca tcgagggcgg ccgggaagag tggagccacg tggacaaccc tcctgttctg      240

gaagattttc tgggccatca gggcctgaac accgacgccg tgatcaacaa catcgaggat      300

gccgtgaagc tgttcatagg agatgatttc tttgagttcc tggtcgagga atccaaccgc      360

tattacaacc agaagagaaa caacttcaag ctgagcaaga aaagcctgaa gtggaaggac      420

atcacccctc aggagatgaa aaagttcctg ggactgatcg ttctgatggg acaggtgcgg      480

aaggacagaa gggatgatta ctggacaacc gaaccttgga ccgagacccc ttactttggc      540

aagaccatga ccagagacag attcagacag atctggaaag cctggcactt caacaacaat      600

gctgatatcg tgaacgagtc tgatagactg tgtaaagtgc ggccagtgtt ggattacttc      660

gtgcctaagt tcatcaacat ctataagcct caccagcagc tgagcctgga tgaaggcatc      720

gtgccctggc ggggcagact gttcttcaga gtgtacaatg ctggcaagat cgtcaaatac      780

ggcatcctgg tgcgccttct gtgcgagagc gatacaggct acatctgtaa tatggaaatc      840

tactgcggcg agggcaaaag actgctggaa accatccaga ccgtcgtttc cccttatacc      900

gacagctggt accacatcta catggacaac tactacaatt ctgtggccaa ctgcgaggcc      960

ctgatgaaga acaagtttag aatctgcggc acaatcagaa aaaacagagg catccctaag     1020

gacttccaga ccatctctct gaagaagggc gaaaccaagt tcatcagaaa gaacgacatc     1080

ctgctccaag tgtggcagtc caagaaaccc gtgtacctga tcagcagcat ccatagcgcc     1140

gagatggaag aaagccagaa catcgacaga acaagcaaga agaagatcgt gaagcccaat     1200

gctctgatcg actacaacaa gcacatgaaa ggcgtggacc gggccgacca gtacctgtct     1260

tattactcta tcctgagaag aacagtgaaa tggaccaaga gactggccat gtacatgatc     1320

aattgcgccc tgttcaacag ctacgccgtg tacaagtccg tgcgacaaag aaaaatggga     1380

ttcaagatgt tcctgaagca gacagccatc cactggctga cagacgacat tcctgaggac     1440

atggacattg tgccagatct gcaacctgtg cccagcacct ctggtatgag agctaagcct     1500

cccaccagcg atcctccatg tagactgagc atggacatgc ggaagcacac cctgcaggcc     1560

atcgtcggca gcggcaagaa gaagaacatc cttagacggt gcagggtgtg cagcgtgcac     1620

aagctgcgga gcgagactcg gtacatgtgc aagttttgca acattcccct gcacaaggga     1680

gcctgcttcg agaagtacca caccctgaag aattactag                            1719


<210>  12
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  12

Met Ala Gln His Ser Asp Tyr Ser Asp Asp Glu Phe Cys Ala Asp Lys 
1               5                   10                  15      


Leu Ser Asn Tyr Ser Cys Asp Ser Asp Leu Glu Asn Ala Ser Thr Ser 
            20                  25                  30          


Asp Glu Asp Ser Ser Asp Asp Glu Val Met Val Arg Pro Arg Thr Leu 
        35                  40                  45              


Arg Arg Arg Arg Ile Ser Ser Ser Ser Ser Asp Ser Glu Ser Asp Ile 
    50                  55                  60                  


Glu Gly Gly Arg Glu Glu Trp Ser His Val Asp Asn Pro Pro Val Leu 
65                  70                  75                  80  


Glu Asp Phe Leu Gly His Gln Gly Leu Asn Thr Asp Ala Val Ile Asn 
                85                  90                  95      


Asn Ile Glu Asp Ala Val Lys Leu Phe Ile Gly Asp Asp Phe Phe Glu 
            100                 105                 110         


Phe Leu Val Glu Glu Ser Asn Arg Tyr Tyr Asn Gln Lys Arg Asn Asn 
        115                 120                 125             


Phe Lys Leu Ser Lys Lys Ser Leu Lys Trp Lys Asp Ile Thr Pro Gln 
    130                 135                 140                 


Glu Met Lys Lys Phe Leu Gly Leu Ile Val Leu Met Gly Gln Val Arg 
145                 150                 155                 160 


Lys Asp Arg Arg Asp Asp Tyr Trp Thr Thr Glu Pro Trp Thr Glu Thr 
                165                 170                 175     


Pro Tyr Phe Gly Lys Thr Met Thr Arg Asp Arg Phe Arg Gln Ile Trp 
            180                 185                 190         


Lys Ala Trp His Phe Asn Asn Asn Ala Asp Ile Val Asn Glu Ser Asp 
        195                 200                 205             


Arg Leu Cys Lys Val Arg Pro Val Leu Asp Tyr Phe Val Pro Lys Phe 
    210                 215                 220                 


Ile Asn Ile Tyr Lys Pro His Gln Gln Leu Ser Leu Asp Glu Gly Ile 
225                 230                 235                 240 


Val Pro Trp Arg Gly Arg Leu Phe Phe Arg Val Tyr Asn Ala Gly Lys 
                245                 250                 255     


Ile Val Lys Tyr Gly Ile Leu Val Arg Leu Leu Cys Glu Ser Asp Thr 
            260                 265                 270         


Gly Tyr Ile Cys Asn Met Glu Ile Tyr Cys Gly Glu Gly Lys Arg Leu 
        275                 280                 285             


Leu Glu Thr Ile Gln Thr Val Val Ser Pro Tyr Thr Asp Ser Trp Tyr 
    290                 295                 300                 


His Ile Tyr Met Asp Asn Tyr Tyr Asn Ser Val Ala Asn Cys Glu Ala 
305                 310                 315                 320 


Leu Met Lys Asn Lys Phe Arg Ile Cys Gly Thr Ile Arg Lys Asn Arg 
                325                 330                 335     


Gly Ile Pro Lys Asp Phe Gln Thr Ile Ser Leu Lys Lys Gly Glu Thr 
            340                 345                 350         


Lys Phe Ile Arg Lys Asn Asp Ile Leu Leu Gln Val Trp Gln Ser Lys 
        355                 360                 365             


Lys Pro Val Tyr Leu Ile Ser Ser Ile His Ser Ala Glu Met Glu Glu 
    370                 375                 380                 


Ser Gln Asn Ile Asp Arg Thr Ser Lys Lys Lys Ile Val Lys Pro Asn 
385                 390                 395                 400 


Ala Leu Ile Asp Tyr Asn Lys His Met Lys Gly Val Asp Arg Ala Asp 
                405                 410                 415     


Gln Tyr Leu Ser Tyr Tyr Ser Ile Leu Arg Arg Thr Val Lys Trp Thr 
            420                 425                 430         


Lys Arg Leu Ala Met Tyr Met Ile Asn Cys Ala Leu Phe Asn Ser Tyr 
        435                 440                 445             


Ala Val Tyr Lys Ser Val Arg Gln Arg Lys Met Gly Phe Lys Met Phe 
    450                 455                 460                 


Leu Lys Gln Thr Ala Ile His Trp Leu Thr Asp Asp Ile Pro Glu Asp 
465                 470                 475                 480 


Met Asp Ile Val Pro Asp Leu Gln Pro Val Pro Ser Thr Ser Gly Met 
                485                 490                 495     


Arg Ala Lys Pro Pro Thr Ser Asp Pro Pro Cys Arg Leu Ser Met Asp 
            500                 505                 510         


Met Arg Lys His Thr Leu Gln Ala Ile Val Gly Ser Gly Lys Lys Lys 
        515                 520                 525             


Asn Ile Leu Arg Arg Cys Arg Val Cys Ser Val His Lys Leu Arg Ser 
    530                 535                 540                 


Glu Thr Arg Tyr Met Cys Lys Phe Cys Asn Ile Pro Leu His Lys Gly 
545                 550                 555                 560 


Ala Cys Phe Glu Lys Tyr His Thr Leu Lys Asn Tyr 
                565                 570         


<210>  13
<211>  1719
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  13
atggcccagc acagcgacta ccccgacgac gagttcagag ccgataagct gagtaactac       60

agctgcgaca gcgacctgga aaacgccagc acatccgacg aggacagctc tgacgacgag      120

gtgatggtgc ggcccagaac cctgagacgg agaagaatca gcagctctag cagcgactct      180

gaatccgaca tcgagggcgg ccgggaagag tggagccacg tggacaaccc tcctgttctg      240

gaagattttc tgggccatca gggcctgaac accgacgccg tgatcaacaa catcgaggat      300

gccgtgaagc tgttcatagg agatgatttc tttgagttcc tggtcgagga atccaaccgc      360

tattacaacc agaatagaaa caacttcaag ctgagcaaga aaagcctgaa gtggaaggac      420

atcacccctc aggagatgaa aaagttcctg ggactgatcg ttctgatggg acaggtgcgg      480

aaggacagaa gggatgatta ctggacaacc gaaccttgga ccgagacccc ttactttggc      540

aagaccatga ccagagacag attcagacag atctggaaag cctggcactt caacaacaat      600

gctgatatcg tgaacgagtc tgatagactg tgtaaagtgc ggccagtgtt ggattacttc      660

gtgcctaagt tcatcaacat ctataagcct caccagcagc tgagcctgga tgaaggcatc      720

gtgccctggc ggggcagact gttcttcaga gtgtacaatg ctggcaagat cgtcaaatac      780

ggcatcctgg tgcgccttct gtgcgagagc gatacaggct acatctgtaa tatggaaatc      840

tactgcggcg agggcaaaag actgctggaa accatccaga ccgtcgtttc cccttatacc      900

gacagctggt accacatcta catggacaac tactacaatt ctgtggccaa ctgcgaggcc      960

ctgatgaaga acaagtttag aatctgcggc acaatcagaa aaaacagagg catccctaag     1020

gacttccaga ccatctctct gaagaagggc gaaaccaagt tcatcagaaa gaacgacatc     1080

ctgctccaag tgtggcagtc caagaaaccc gtgtacctga tcagcagcat ccatagcgcc     1140

gagatggaag aaagccagaa catcgacaga acaagcaaga agaagatcgt gaagcccaat     1200

gctctgatcg actacaacaa gcacatgaaa ggcgtggacc gggccgacca gtacctgtct     1260

tattactcta tcctgagaag aacagtgaaa tggaccaaga gactggccat gtacatgatc     1320

aattgcgccc tgttcaacag ctacgccgtg tacaagtccg tgcgacaaag aaaaatggga     1380

ttcaagatgt tcctgaagca gacagccatc cactggctga cagacgacat tcctgaggac     1440

atggacattg tgccagatct gcaacctgtg cccagcacct ctggtatgag agctaagcct     1500

cccaccagcg atcctccatg tagactgagc atggacatgc ggaagcacac cctgcaggcc     1560

atcgtcggca gcggcaagaa gaagaacatc cttagacggt gcagggtgtg cagcgtgcac     1620

aagctgcgga gcgagactcg gtacatgtgc aagttttgca acattcccct gcacaaggga     1680

gcctgcttcg agaagtacca caccctgaag aattactag                            1719


<210>  14
<211>  572
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  14

Met Ala Gln His Ser Asp Tyr Pro Asp Asp Glu Phe Arg Ala Asp Lys 
1               5                   10                  15      


Leu Ser Asn Tyr Ser Cys Asp Ser Asp Leu Glu Asn Ala Ser Thr Ser 
            20                  25                  30          


Asp Glu Asp Ser Ser Asp Asp Glu Val Met Val Arg Pro Arg Thr Leu 
        35                  40                  45              


Arg Arg Arg Arg Ile Ser Ser Ser Ser Ser Asp Ser Glu Ser Asp Ile 
    50                  55                  60                  


Glu Gly Gly Arg Glu Glu Trp Ser His Val Asp Asn Pro Pro Val Leu 
65                  70                  75                  80  


Glu Asp Phe Leu Gly His Gln Gly Leu Asn Thr Asp Ala Val Ile Asn 
                85                  90                  95      


Asn Ile Glu Asp Ala Val Lys Leu Phe Ile Gly Asp Asp Phe Phe Glu 
            100                 105                 110         


Phe Leu Val Glu Glu Ser Asn Arg Tyr Tyr Asn Gln Asn Arg Asn Asn 
        115                 120                 125             


Phe Lys Leu Ser Lys Lys Ser Leu Lys Trp Lys Asp Ile Thr Pro Gln 
    130                 135                 140                 


Glu Met Lys Lys Phe Leu Gly Leu Ile Val Leu Met Gly Gln Val Arg 
145                 150                 155                 160 


Lys Asp Arg Arg Asp Asp Tyr Trp Thr Thr Glu Pro Trp Thr Glu Thr 
                165                 170                 175     


Pro Tyr Phe Gly Lys Thr Met Thr Arg Asp Arg Phe Arg Gln Ile Trp 
            180                 185                 190         


Lys Ala Trp His Phe Asn Asn Asn Ala Asp Ile Val Asn Glu Ser Asp 
        195                 200                 205             


Arg Leu Cys Lys Val Arg Pro Val Leu Asp Tyr Phe Val Pro Lys Phe 
    210                 215                 220                 


Ile Asn Ile Tyr Lys Pro His Gln Gln Leu Ser Leu Asp Glu Gly Ile 
225                 230                 235                 240 


Val Pro Trp Arg Gly Arg Leu Phe Phe Arg Val Tyr Asn Ala Gly Lys 
                245                 250                 255     


Ile Val Lys Tyr Gly Ile Leu Val Arg Leu Leu Cys Glu Ser Asp Thr 
            260                 265                 270         


Gly Tyr Ile Cys Asn Met Glu Ile Tyr Cys Gly Glu Gly Lys Arg Leu 
        275                 280                 285             


Leu Glu Thr Ile Gln Thr Val Val Ser Pro Tyr Thr Asp Ser Trp Tyr 
    290                 295                 300                 


His Ile Tyr Met Asp Asn Tyr Tyr Asn Ser Val Ala Asn Cys Glu Ala 
305                 310                 315                 320 


Leu Met Lys Asn Lys Phe Arg Ile Cys Gly Thr Ile Arg Lys Asn Arg 
                325                 330                 335     


Gly Ile Pro Lys Asp Phe Gln Thr Ile Ser Leu Lys Lys Gly Glu Thr 
            340                 345                 350         


Lys Phe Ile Arg Lys Asn Asp Ile Leu Leu Gln Val Trp Gln Ser Lys 
        355                 360                 365             


Lys Pro Val Tyr Leu Ile Ser Ser Ile His Ser Ala Glu Met Glu Glu 
    370                 375                 380                 


Ser Gln Asn Ile Asp Arg Thr Ser Lys Lys Lys Ile Val Lys Pro Asn 
385                 390                 395                 400 


Ala Leu Ile Asp Tyr Asn Lys His Met Lys Gly Val Asp Arg Ala Asp 
                405                 410                 415     


Gln Tyr Leu Ser Tyr Tyr Ser Ile Leu Arg Arg Thr Val Lys Trp Thr 
            420                 425                 430         


Lys Arg Leu Ala Met Tyr Met Ile Asn Cys Ala Leu Phe Asn Ser Tyr 
        435                 440                 445             


Ala Val Tyr Lys Ser Val Arg Gln Arg Lys Met Gly Phe Lys Met Phe 
    450                 455                 460                 


Leu Lys Gln Thr Ala Ile His Trp Leu Thr Asp Asp Ile Pro Glu Asp 
465                 470                 475                 480 


Met Asp Ile Val Pro Asp Leu Gln Pro Val Pro Ser Thr Ser Gly Met 
                485                 490                 495     


Arg Ala Lys Pro Pro Thr Ser Asp Pro Pro Cys Arg Leu Ser Met Asp 
            500                 505                 510         


Met Arg Lys His Thr Leu Gln Ala Ile Val Gly Ser Gly Lys Lys Lys 
        515                 520                 525             


Asn Ile Leu Arg Arg Cys Arg Val Cys Ser Val His Lys Leu Arg Ser 
    530                 535                 540                 


Glu Thr Arg Tyr Met Cys Lys Phe Cys Asn Ile Pro Leu His Lys Gly 
545                 550                 555                 560 


Ala Cys Phe Glu Lys Tyr His Thr Leu Lys Asn Tyr 
                565                 570         


<210>  15
<211>  545
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Sequence

<400>  15
ccctaaaatg ggcaaacatt gcaagcagca aacagcaaac acacagccct ccctgcctgc       60

tgaccttgga gctggggcag aggtcagaga cctctctggg cccatgccac ctccaacatc      120

cactcgaccc cttggaattt cggtggagag gagcagaggt tgtcctggcg tggtttaggt      180

agtgtgagag gggaatgact cctttcggta agtgcagtgg aagctgtaca ctgcccaggc      240

aaagcgtccg ggcagcgtag gcgggcgact cagatcccag ccagtggact tagcccctgt      300

ttgctcctcc gataactggg gtgaccttgg ttaatattca ccagcagcct cccccgttgc      360

ccctctggat ccactgctta aatacggacg aggacagggc cctgtctcct cagcttcagg      420

caccaccact gacctgggac agtgaatccg gactctaagg taaatataaa atttttaagt      480

gtataatgtg ttaaactact gattctaatt gtttgtgtat tttagattcc aacctatgga      540

actga                                                                  545


