                         SEQUENCE LISTING

<110>  A2 Biotherapeutics, Inc.
 
<120>  PAG1 FUSION PROTEINS AND METHODS OF MAKING AND USING SAME

<130>  A2BI-016/01WO 331656-2066

<150>  US 63/018,881
<151>  2020-05-01

<160>  381   

<170>  PatentIn version 3.5

<210>  1
<211>  432
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
1               5                   10                  15      


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
            20                  25                  30          


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
        35                  40                  45              


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
    50                  55                  60                  


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
65                  70                  75                  80  


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
                85                  90                  95      


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
            100                 105                 110         


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
        115                 120                 125             


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
    130                 135                 140                 


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
145                 150                 155                 160 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
                165                 170                 175     


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
            180                 185                 190         


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
        195                 200                 205             


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
    210                 215                 220                 


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
225                 230                 235                 240 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
                245                 250                 255     


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
            260                 265                 270         


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
        275                 280                 285             


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
    290                 295                 300                 


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
305                 310                 315                 320 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
                325                 330                 335     


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
            340                 345                 350         


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
        355                 360                 365             


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
    370                 375                 380                 


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
385                 390                 395                 400 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
                405                 410                 415     


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            420                 425                 430         


<210>  2
<211>  396
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  2

Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp 
1               5                   10                  15      


His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg 
            20                  25                  30          


Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn 
        35                  40                  45              


Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr 
    50                  55                  60                  


Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu 
65                  70                  75                  80  


Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu 
                85                  90                  95      


Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala 
            100                 105                 110         


Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu 
        115                 120                 125             


Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu 
    130                 135                 140                 


Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu 
145                 150                 155                 160 


Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu 
                165                 170                 175     


Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala 
            180                 185                 190         


Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser 
        195                 200                 205             


Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val 
    210                 215                 220                 


Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly 
225                 230                 235                 240 


Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys 
                245                 250                 255     


Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu 
            260                 265                 270         


Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly 
        275                 280                 285             


Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr 
    290                 295                 300                 


Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn 
305                 310                 315                 320 


Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr 
                325                 330                 335     


Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu 
            340                 345                 350         


Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu Gly Thr 
        355                 360                 365             


Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu Ser Ile 
    370                 375                 380                 


Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
385                 390                 395     


<210>  3
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated PAG1 intracellular domain

<400>  3

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
        275                 280                 285             


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
    290                 295                 300                 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
305                 310                 315                 320 


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala 
                325                 330                 335     


Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr 
            340                 345                 350         


Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu Gly Thr Asn Gly His His 
        355                 360                 365             


Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu Ser Ile Ser Asp Leu Gln 
    370                 375                 380                 


Gln Gly Arg Asp Ile Thr Arg Leu 
385                 390         


<210>  4
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  4

Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val 
1               5                   10                  15      


Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys 
            20                  25                  30          


Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser 
        35                  40                  45              


Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly 
    50                  55                  60                  


Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln 
65                  70                  75                  80  


Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys 
                85                  90                  95      


Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala 
            100                 105                 110         


Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly 
        115                 120                 125             


Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys 
    130                 135                 140                 


Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro 
145                 150                 155                 160 


Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn 
                165                 170                 175     


Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr 
            180                 185                 190         


Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys 
        195                 200                 205             


Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met 
    210                 215                 220                 


Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln 
225                 230                 235                 240 


Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro 
                245                 250                 255     


Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp 
            260                 265                 270         


Phe Glu Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser 
        275                 280                 285             


Glu Glu Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu 
    290                 295                 300                 


Glu Glu Lys Ala Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro 
305                 310                 315                 320 


Lys Glu Asn Asp Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp 
                325                 330                 335     


Ile Thr Arg Leu 
            340 


<210>  5
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  5

Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys 
1               5                   10                  15      


His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp 
            20                  25                  30          


Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met 
        35                  40                  45              


Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met 
    50                  55                  60                  


Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala 
65                  70                  75                  80  


Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr 
                85                  90                  95      


Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu 
            100                 105                 110         


Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser 
        115                 120                 125             


Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu 
    130                 135                 140                 


Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu 
145                 150                 155                 160 


Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr 
                165                 170                 175     


Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu 
            180                 185                 190         


Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser 
        195                 200                 205             


Val Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr 
    210                 215                 220                 


Val Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser 
225                 230                 235                 240 


Pro Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys 
                245                 250                 255     


Thr Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro 
            260                 265                 270         


Glu Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys 
        275                 280                 285             


Ala Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn 
    290                 295                 300                 


Asp Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg 
305                 310                 315                 320 


Leu 
    


<210>  6
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  6

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu 
        275                 280                 285     


<210>  7
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  7

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
        275                 280                 285             


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
    290                 295                 300                 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
305                 310                 315                 320 


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser 
                325                 330     


<210>  8
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  8

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
        275                 280                 285             


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
    290                 295                 300                 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
305                 310                 315                 320 


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala 
                325                 330                 335     


Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr 
            340                 345                 350         


Leu Asn Arg Glu Glu Glu Lys Ala 
        355                 360 


<210>  9
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  9

Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys 
1               5                   10                  15      


His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp 
            20                  25                  30          


Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met 
        35                  40                  45              


Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met 
    50                  55                  60                  


Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala 
65                  70                  75                  80  


Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr 
                85                  90                  95      


Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu 
            100                 105                 110         


Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser 
        115                 120                 125             


Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu 
    130                 135                 140                 


Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu 
145                 150                 155                 160 


Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr 
                165                 170                 175     


Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu 
            180                 185                 190         


Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser 
        195                 200                 205             


Val Asn Lys Pro Gly Gln Leu 
    210                 215 


<210>  10
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  10

Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
1               5                   10                  15      


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
            20                  25                  30          


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
        35                  40                  45              


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
    50                  55                  60                  


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
65                  70                  75                  80  


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
                85                  90                  95      


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu 
            100                 105                 110 


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 transmembrane domain

<400>  11

Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
1               5                   10                  15      


Leu Ile Phe Leu 
            20  


<210>  12
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 transmembrane domain

<400>  12

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile Leu 
            20              


<210>  13
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  13

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys Asn His 
            20                  25      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 hinge domain

<400>  14

Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
1               5                   10                  15  


<210>  15
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 D3D4 domain

<400>  15

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu 
            20  


<210>  16
<211>  63
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  16

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    50                  55                  60              


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  17

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
        35                  40              


<210>  18
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  18

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  19
<211>  135
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge domain

<400>  19
accacgacgc cagcgccgcg accaccaaca ccggcgccca ccatcgcgtc gcagcccctg       60

tccctgcgcc cagaggcgtg ccggccagcg gcggggggcg cagtgcacac gagggggctg      120

gacttcgcct gtgat                                                       135


<210>  20
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain

<400>  20

Cys Thr Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys 
1               5                   10                  15      


Ser Asn Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser 
            20                  25                  30          


Pro Leu Phe Pro Gly Pro Ser Lys Pro 
        35                  40      


<210>  21
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 hinge domain

<400>  21
tgtaccattg aagttatgta tcctcctcct tacctagaca atgagaagag caatggaacc       60

attatccatg tgaaagggaa acacctttgt ccaagtcccc tatttcccgg accttctaag      120

ccc                                                                    123


<210>  22
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  22

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  23

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  24
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  24

Phe Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  25
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  25

Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile His 
1               5                   10          


<210>  26
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  26

Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly Lys 
        


<210>  27
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  27

Glu Glu Ile Thr Tyr Ala Met Asp Tyr 
1               5                   


<210>  28
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L1

<400>  28

Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp 
1               5                   10                  15      


<210>  29
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L2

<400>  29

Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
1               5                   10          


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-L3

<400>  30

Met Gln Gly Ser His Val Pro Arg Thr 
1               5                   


<210>  31
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H1

<400>  31

Ser Gly Tyr Thr Phe Thr Ser Tyr His Met His 
1               5                   10      


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H2

<400>  32

Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02 CDR-H3

<400>  33

Glu Gly Thr Tyr Tyr Ala Met Asp Tyr 
1               5                   


<210>  34
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1/A2


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is His or Arg

<400>  34

Val Leu Xaa Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  35
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-001765 PA2.1 scFv (mouse)

<400>  35

Met Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
1               5                   10                  15      


Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly 
            20                  25                  30          


Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
        35                  40                  45              


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
    50                  55                  60                  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
65                  70                  75                  80  


Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser His 
                85                  90                  95      


Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln 
        115                 120                 125             


Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His 
145                 150                 155                 160 


Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
                165                 170                 175     


Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys 
            180                 185                 190         


Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met 
        195                 200                 205             


His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala 
    210                 215                 220                 


Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
225                 230                 235                 240 


Val Thr Val Ser Ser Tyr Gly 
                245         


<210>  36
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002159 PA2.1.8 scFv (humanized)

<400>  36

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
        35                  40                  45              


Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu 
    130                 135                 140                 


Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  37
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002160 PA2.1.9 scFv (humanized)

<400>  37

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Trp 
        35                  40                  45              


Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu 
    130                 135                 140                 


Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln 
                165                 170                 175     


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  38
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002161 PA2.1.10 scFv (humanized)

<400>  38

Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Leu 
1               5                   10                  15      


Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Gly Trp 
        35                  40                  45              


Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  39
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002162

<400>  39

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Ile 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Trp 
        35                  40                  45              


Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Val Lys 
                245 


<210>  40
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002163 PA2.1.18 scFv (humanized)

<400>  40

Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr His Met 
            20                  25                  30          


His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
        35                  40                  45              


Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys Phe Lys Gly 
    50                  55                  60                  


Lys Ala Thr Leu Thr Ala Asp Lys Ser Thr Asn Thr Ala Tyr Met Glu 
65                  70                  75                  80  


Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      


Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Asp Val Gln Met Thr Gln Ser Pro Ser Thr Leu 
    130                 135                 140                 


Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser Ser Ser Gln 
145                 150                 155                 160 


Ser Ile Val His Ser Asn Gly Asn Thr Tyr Met Glu Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg 
            180                 185                 190         


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys His Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Val Lys 
                245 


<210>  41
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002164 BB7.2 scFv (mouse)

<400>  41

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Thr Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Leu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Leu Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Val Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  42
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002165 BB7.2.1 scFv (humanized)

<400>  42

Gln Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Ala Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Asn Leu Asp Ser Val Ser Ala Ala Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Lys Gly Ser 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Pro 
225                 230                 235                 240 


Gly Thr Lys Val Asp Ile Lys 
                245         


<210>  43
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002166 BB7.2.2 scFv (humanized)

<400>  43

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Leu Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Lys Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro Ser 
    130                 135                 140                 


Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Val Lys 
                245         


<210>  44
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002167 BB7.2.3 scFv (humanized)

<400>  44

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  45
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002168 BB7.2.5 scFv (humanized)

<400>  45

Gln Val Thr Leu Lys Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Thr Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Arg Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Ala Asp Lys Ser Met Asp Thr Ser Phe 
65                  70                  75                  80  


Met Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Leu Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser Pro Gly 
    130                 135                 140                 


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Ser Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  46
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002169 BB7.2.6 scFv (humanized)

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


His Met His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asp Gly Ser Thr Gln Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Thr Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr Leu Asp Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly 
    210                 215                 220                 


Val Tyr Tyr Cys Met Gln Gly Ser His Val Pro Arg Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  47
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 transmembrane domain and PAG1 intracellular domain

<400>  47

Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
1               5                   10                  15      


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
            20                  25                  30          


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
        35                  40                  45              


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
    50                  55                  60                  


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
65                  70                  75                  80  


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
                85                  90                  95      


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
            100                 105                 110         


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
        115                 120                 125             


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
    130                 135                 140                 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
145                 150                 155                 160 


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
                165                 170                 175     


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
            180                 185                 190         


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
        195                 200                 205             


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
    210                 215                 220                 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
225                 230                 235                 240 


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
                245                 250                 255     


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
            260                 265                 270         


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
        275                 280                 285             


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
    290                 295                 300                 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
305                 310                 315                 320 


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
                325                 330                 335     


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
        355                 360                 365             


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
    370                 375                 380                 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
385                 390                 395                 400 


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
                405                 410                 415     


<210>  48
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 transmembrane domain

<400>  48

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile 
                85  


<210>  49
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha transmembrane domain

<400>  49

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile 
        35                  40                  45              


Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val 
    50                  55                  60                  


Ile Thr Leu Tyr Cys Asn His 
65                  70      


<210>  50
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PAG1 domain NA

<400>  50
atggggcccg cggggagcct gctgggcagc ggacagatgc agatcaccct gtggggaagt       60

ctggctgctg tcgccatttt cttcgtcatc accttcctca tcttcctgtg ctctagttgt      120

gacagggaaa agaagccgcg acagcatagt ggggaccatg agaacctgat gaacgtgcct      180

tcagacaagg agatgttcag ccgttcagtt actagcctgg caacagatgc tcctgccagc      240

agtgagcaga atggggcact caccaatggg gacattcttt cagaggacag tactctgacc      300

tgcatgcagc attacgagga agtccagaca tcggcctcgg atctgctgga ttcccaggac      360

agcacaggga aaccaaaatg tcatcagagt cgggagctgc ccagaatccc tcccgagagc      420

gcagtggata ccatgctcac ggcgagaagt gtggacgggg accaggggct ggggatggaa      480

gggccctatg aagtgctcaa ggacagctcc tcccaagaaa acatggtgga ggactgcttg      540

tatgaaactg tgaaagagat caaggaggtg gctgcagctg cacacctgga gaaaggccac      600

agtggcaagg caaaatctac ttctgcctcg aaagagctcc cagggcccca gactgaaggc      660

aaagctgagt ttgctgaata tgcctcggtg gacagaaaca aaaaatgtcg tcaaagtgtt      720

aatgtagaga gtatccttgg aaattcatgt gatccagaag aggaggcccc accacctgtc      780

cctgttaagc ttctggacga gaatgaaaac cttcaggaga aggaaggggg agaggcggaa      840

gagagtgcca cagacacgac cagtgaaact aacaagagat ttagctcatt gtcatacaag      900

tctcgggaag aagaccccac tctcacagaa gaagagatct cagctatgta ctcatcagta      960

aataaacctg gacagttagt gaataaatcg gggcagtcgc ttacagttcc ggagtccacc     1020

tacacctcca ttcaagggga cccacagagg tcaccctcct cctgtaatga tctctatgct     1080

actgttaaag acttcgaaaa aactccaaac agcacacttc caccagcagg gaggcccagc     1140

gaggagccag agcctgatta tgaagcgata cagactctca acagagagga agaaaaggcc     1200

accctgggga ccaatggcca ccacggtctc gtcccaaagg agaacgacta cgagagcata     1260

agtgacttgc agcaaggcag agatattacc aggctctag                            1299


<210>  51

<400>  51
000

<210>  52

<400>  52
000

<210>  53

<400>  53
000

<210>  54

<400>  54
000

<210>  55
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  55

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  56
<211>  81
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 transmembrane domain

<400>  56
ttctgggtgc tggtcgttgt gggcggcgtg ctggcctgct acagcctgct ggtgacagtg       60

gccttcatca tcttttgggt g                                                 81


<210>  57
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta transmembrane domain

<400>  57

Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210>  58
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2R beta transmembrane domain

<400>  58
attccgtggc tcggccacct cctcgtgggc ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210>  59
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  59

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  60
<211>  336
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  60
agagtgaagt tcagcaggag cgcagacgcc cccgcgtaca agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttggacaa gcgtagaggc      120

cgggaccctg agatgggggg aaagccgaga aggaagaacc ctcaggaagg cctgtacaat      180

gaactgcaga aagataagat ggcggaggcc tacagtgaga ttgggatgaa aggcgagcgc      240

cggaggggca aggggcacga tggcctttac cagggactca gtacagccac caaggacacc      300

tacgacgccc ttcacatgca ggccctgccc cctcgc                                336


<210>  61
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ITAM


<220>
<221>  MISC_FEATURE
<222>  (2)..(3)
<223>  Xaa is any amino acid

<400>  61

Tyr Xaa Xaa Leu 
1               


<210>  62
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  62

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu His Met Gln Ala Leu Pro Pro Arg 
        35                  40              


<210>  63
<211>  129
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 zeta activation domain

<400>  63
agagtgaagt tcagcaggag cgcagacgcc cccgcgtacc agcagggcca gaaccagctc       60

tataacgagc tcaatctagg acgaagagag gagtacgatg ttttgcacat gcaggccctg      120

ccccctcgc                                                              129


<210>  64
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  64

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  65
<211>  123
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD28 co-stimulatory domain

<400>  65
aggagcaagc ggagcagact gctgcacagc gactacatga acatgacccc ccggaggcct       60

ggccccaccc ggaagcacta ccagccctac gcccctccca gggatttcgc cgcctaccgg      120

agc                                                                    123


<210>  66
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL-2R beta intracellular domain

<400>  66

Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
65                  70                  75                  80  


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
                85                  90                  


<210>  67
<211>  282
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL-2R beta intracellular domain

<400>  67
aactgcagga acaccgggcc atggctgaag aaggtcctga agtgtaacac cccagacccc       60

tcgaagttct tttcccagct gagctcagag catggaggcg acgtccagaa gtggctctct      120

tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg cacctgagat ctcgccacta      180

gaagtgctgg agagggacaa ggtgacgcag ctgctccccc tgaacactga tgcctacttg      240

tctctccaag aactccaggg tcaggaccca actcacttgg tg                         282


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  STAT5-recruitment motif

<400>  68

Tyr Leu Ser Leu 
1               


<210>  69
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain

<400>  69

Val Ile Gly Phe Arg Ile Leu Leu Leu Lys Val Ala Gly Phe Asn Leu 
1               5                   10                  15      


Leu Met Thr Leu Arg Leu Trp 
            20              


<210>  70
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR alpha transmembrane domain

<400>  70
gtgattgggt tccgaatcct cctcctgaaa gtggccgggt ttaatctgct catgacgctg       60

cggctgtgg                                                               69


<210>  71
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta transmembrane domain

<400>  71

Thr Ile Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val 
1               5                   10                  15      


Leu Val Ser Ala Leu Val Leu 
            20              


<210>  72
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta transmembrane domain

<400>  72
accatcctct atgagatctt gctagggaag gccaccttgt atgccgtgct ggtcagtgcc       60

ctcgtgctg                                                               69


<210>  73
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta transmembrane domain

<400>  73

Leu Cys Tyr Leu Leu Asp Gly Ile Leu Phe Ile Tyr Gly Val Ile Leu 
1               5                   10                  15      


Thr Ala Leu Phe Leu 
            20      


<210>  74

<400>  74
000

<210>  75
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 delta intracellular domain

<400>  75

Gly His Glu Thr Gly Arg Leu Ser Gly Ala Ala Asp Thr Gln Ala Leu 
1               5                   10                  15      


Leu Arg Asn Asp Gln Val Tyr Gln Pro Leu Arg Asp Arg Asp Asp Ala 
            20                  25                  30          


Gln Tyr Ser His Leu Gly Gly Asn Trp Ala Arg Asn Lys Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  76
<211>  269
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 delta intracellular domain

<400>  76
ggacatgaga ctggaaggct gtctggggct gccgacacac aagctctgtt gaggaatgac       60

caggtctatc agcccctccg agatcgagat gatgctcagt acagccacct tggaggaaac      120

tgggctcgga acaagggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagcta                                        269


<210>  77
<211>  300
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon intracellular domain

<400>  77
aagaatagaa aggccaaggc caagcctgtg acacgaggag cgggtgctgg cggcaggcaa       60

aggggacaaa acaaggagag gccaccacct gttcccaacc cagactatga gcccatccgg      120

aaaggccagc gggacctgta ttctggcctg aatcagcgca gaatcggcgg aagcaggagc      180

aagcggagca gactgctgca cagcgactac atgaacatga ccccccggag gcctggcccc      240

acccggaagc actaccagcc ctacgcccct cccagggatt tcgccgccta ccggagctag      300


<210>  78
<211>  89
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 gamma intracellular domain

<400>  78

Gly Gln Asp Gly Val Arg Gln Ser Arg Ala Ser Asp Lys Gln Thr Leu 
1               5                   10                  15      


Leu Pro Asn Asp Gln Leu Tyr Gln Pro Leu Lys Asp Arg Glu Asp Asp 
            20                  25                  30          


Gln Tyr Ser His Leu Gln Gly Asn Gln Leu Arg Arg Asn Gly Gly Ser 
        35                  40                  45              


Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
    50                  55                  60                  


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
65                  70                  75                  80  


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
                85                  


<210>  79
<211>  270
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CD3 gamma intracellular domain

<400>  79
ggacaggatg gagttcgcca gtcgagagct tcagacaagc agactctgtt gcccaatgac       60

cagctctacc agcccctcaa ggatcgagaa gatgaccagt acagccacct tcaaggaaac      120

cagttgagga ggaatggcgg aagcaggagc aagcggagca gactgctgca cagcgactac      180

atgaacatga ccccccggag gcctggcccc acccggaagc actaccagcc ctacgcccct      240

cccagggatt tcgccgccta ccggagctag                                       270


<210>  80
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  80

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  81
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCR beta intracellular domain

<400>  81

Met Ala Met Val Lys Arg Lys Asp Ser Arg 
1               5                   10  


<210>  82
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TCR beta intracellular domain

<400>  82
atggccatgg tcaagagaaa ggattccaga                                        30


<210>  83
<211>  126
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4-1BB intracellular domain

<400>  83
aaacggggca gaaagaaact cctgtatata ttcaaacaac catttatgag gccagtacaa       60

actactcaag aggaagatgg ctgtagctgc cgatttccag aagaagaaga aggaggatgt      120

gaactg                                                                 126


<210>  84
<211>  760
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  transferrin receptor (TFRC)

<400>  84

Met Met Asp Gln Ala Arg Ser Ala Phe Ser Asn Leu Phe Gly Gly Glu 
1               5                   10                  15      


Pro Leu Ser Tyr Thr Arg Phe Ser Leu Ala Arg Gln Val Asp Gly Asp 
            20                  25                  30          


Asn Ser His Val Glu Met Lys Leu Ala Val Asp Glu Glu Glu Asn Ala 
        35                  40                  45              


Asp Asn Asn Thr Lys Ala Asn Val Thr Lys Pro Lys Arg Cys Ser Gly 
    50                  55                  60                  


Ser Ile Cys Tyr Gly Thr Ile Ala Val Ile Val Phe Phe Leu Ile Gly 
65                  70                  75                  80  


Phe Met Ile Gly Tyr Leu Gly Tyr Cys Lys Gly Val Glu Pro Lys Thr 
                85                  90                  95      


Glu Cys Glu Arg Leu Ala Gly Thr Glu Ser Pro Val Arg Glu Glu Pro 
            100                 105                 110         


Gly Glu Asp Phe Pro Ala Ala Arg Arg Leu Tyr Trp Asp Asp Leu Lys 
        115                 120                 125             


Arg Lys Leu Ser Glu Lys Leu Asp Ser Thr Asp Phe Thr Ser Thr Ile 
    130                 135                 140                 


Lys Leu Leu Asn Glu Asn Ser Tyr Val Pro Arg Glu Ala Gly Ser Gln 
145                 150                 155                 160 


Lys Asp Glu Asn Leu Ala Leu Tyr Val Glu Asn Gln Phe Arg Glu Phe 
                165                 170                 175     


Lys Leu Ser Lys Val Trp Arg Asp Gln His Phe Val Lys Ile Gln Val 
            180                 185                 190         


Lys Asp Ser Ala Gln Asn Ser Val Ile Ile Val Asp Lys Asn Gly Arg 
        195                 200                 205             


Leu Val Tyr Leu Val Glu Asn Pro Gly Gly Tyr Val Ala Tyr Ser Lys 
    210                 215                 220                 


Ala Ala Thr Val Thr Gly Lys Leu Val His Ala Asn Phe Gly Thr Lys 
225                 230                 235                 240 


Lys Asp Phe Glu Asp Leu Tyr Thr Pro Val Asn Gly Ser Ile Val Ile 
                245                 250                 255     


Val Arg Ala Gly Lys Ile Thr Phe Ala Glu Lys Val Ala Asn Ala Glu 
            260                 265                 270         


Ser Leu Asn Ala Ile Gly Val Leu Ile Tyr Met Asp Gln Thr Lys Phe 
        275                 280                 285             


Pro Ile Val Asn Ala Glu Leu Ser Phe Phe Gly His Ala His Leu Gly 
    290                 295                 300                 


Thr Gly Asp Pro Tyr Thr Pro Gly Phe Pro Ser Phe Asn His Thr Gln 
305                 310                 315                 320 


Phe Pro Pro Ser Arg Ser Ser Gly Leu Pro Asn Ile Pro Val Gln Thr 
                325                 330                 335     


Ile Ser Arg Ala Ala Ala Glu Lys Leu Phe Gly Asn Met Glu Gly Asp 
            340                 345                 350         


Cys Pro Ser Asp Trp Lys Thr Asp Ser Thr Cys Arg Met Val Thr Ser 
        355                 360                 365             


Glu Ser Lys Asn Val Lys Leu Thr Val Ser Asn Val Leu Lys Glu Ile 
    370                 375                 380                 


Lys Ile Leu Asn Ile Phe Gly Val Ile Lys Gly Phe Val Glu Pro Asp 
385                 390                 395                 400 


His Tyr Val Val Val Gly Ala Gln Arg Asp Ala Trp Gly Pro Gly Ala 
                405                 410                 415     


Ala Lys Ser Gly Val Gly Thr Ala Leu Leu Leu Lys Leu Ala Gln Met 
            420                 425                 430         


Phe Ser Asp Met Val Leu Lys Asp Gly Phe Gln Pro Ser Arg Ser Ile 
        435                 440                 445             


Ile Phe Ala Ser Trp Ser Ala Gly Asp Phe Gly Ser Val Gly Ala Thr 
    450                 455                 460                 


Glu Trp Leu Glu Gly Tyr Leu Ser Ser Leu His Leu Lys Ala Phe Thr 
465                 470                 475                 480 


Tyr Ile Asn Leu Asp Lys Ala Val Leu Gly Thr Ser Asn Phe Lys Val 
                485                 490                 495     


Ser Ala Ser Pro Leu Leu Tyr Thr Leu Ile Glu Lys Thr Met Gln Asn 
            500                 505                 510         


Val Lys His Pro Val Thr Gly Gln Phe Leu Tyr Gln Asp Ser Asn Trp 
        515                 520                 525             


Ala Ser Lys Val Glu Lys Leu Thr Leu Asp Asn Ala Ala Phe Pro Phe 
    530                 535                 540                 


Leu Ala Tyr Ser Gly Ile Pro Ala Val Ser Phe Cys Phe Cys Glu Asp 
545                 550                 555                 560 


Thr Asp Tyr Pro Tyr Leu Gly Thr Thr Met Asp Thr Tyr Lys Glu Leu 
                565                 570                 575     


Ile Glu Arg Ile Pro Glu Leu Asn Lys Val Ala Arg Ala Ala Ala Glu 
            580                 585                 590         


Val Ala Gly Gln Phe Val Ile Lys Leu Thr His Asp Val Glu Leu Asn 
        595                 600                 605             


Leu Asp Tyr Glu Arg Tyr Asn Ser Gln Leu Leu Ser Phe Val Arg Asp 
    610                 615                 620                 


Leu Asn Gln Tyr Arg Ala Asp Ile Lys Glu Met Gly Leu Ser Leu Gln 
625                 630                 635                 640 


Trp Leu Tyr Ser Ala Arg Gly Asp Phe Phe Arg Ala Thr Ser Arg Leu 
                645                 650                 655     


Thr Thr Asp Phe Gly Asn Ala Glu Lys Thr Asp Arg Phe Val Met Lys 
            660                 665                 670         


Lys Leu Asn Asp Arg Val Met Arg Val Glu Tyr His Phe Leu Ser Pro 
        675                 680                 685             


Tyr Val Ser Pro Lys Glu Ser Pro Phe Arg His Val Phe Trp Gly Ser 
    690                 695                 700                 


Gly Ser His Thr Leu Pro Ala Leu Leu Glu Asn Leu Lys Leu Arg Lys 
705                 710                 715                 720 


Gln Asn Asn Gly Ala Phe Asn Glu Thr Leu Phe Arg Asn Gln Leu Ala 
                725                 730                 735     


Leu Ala Thr Trp Thr Ile Gln Gly Ala Ala Asn Ala Leu Ser Gly Asp 
            740                 745                 750         


Val Trp Asp Ile Asp Asn Glu Phe 
        755                 760 


<210>  85
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta intracellular domain

<400>  85

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
    50                  55                  60                  


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
65                  70                  75                  80  


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
                85                  90                  95      


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
            100                 105                 110         


Arg 
    


<210>  86
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hinge domain

<400>  86

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
65                  70                  75                  


<210>  87
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  87

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


<210>  88
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 transmembrane domain

<400>  88

Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe Leu Ile 
            20          


<210>  89
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 transmembrane domain

<400>  89

Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser Asp 
1               5                   10                  15      


Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro 
            20                  25                  30          


Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
        35                  40                  45              


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
    50                  55                  60                  


Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu 
65                  70                  75                  80  


Leu Leu Phe Leu Ile Leu 
                85      


<210>  90
<211>  360
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  90

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
        275                 280                 285             


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
    290                 295                 300                 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
305                 310                 315                 320 


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala 
                325                 330                 335     


Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr 
            340                 345                 350         


Leu Asn Arg Glu Glu Glu Lys Ala 
        355                 360 


<210>  91
<211>  331
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  91

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
        275                 280                 285             


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
    290                 295                 300                 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
305                 310                 315                 320 


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser 
                325                 330     


<210>  92
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  92

Asp Arg Glu Lys Lys Pro Arg Gln His Ser Gly Asp His Glu Asn Leu 
1               5                   10                  15      


Met Asn Val Pro Ser Asp Lys Glu Met Phe Ser Arg Ser Val Thr Ser 
            20                  25                  30          


Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr 
        35                  40                  45              


Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr Leu Thr Cys Met Gln His 
    50                  55                  60                  


Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp 
65                  70                  75                  80  


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
                85                  90                  95      


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
            100                 105                 110         


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
        115                 120                 125             


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
    130                 135                 140                 


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
145                 150                 155                 160 


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
                165                 170                 175     


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
            180                 185                 190         


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
        195                 200                 205             


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
    210                 215                 220                 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
225                 230                 235                 240 


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
                245                 250                 255     


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
            260                 265                 270         


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu 
        275                 280                 285     


<210>  93
<211>  347
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  93

Asp Arg Glu Lys Lys Pro Arg Leu Ser Glu Asp Ser Thr Leu Thr Cys 
1               5                   10                  15      


Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp Leu Leu Asp 
            20                  25                  30          


Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu 
        35                  40                  45              


Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg 
    50                  55                  60                  


Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val 
65                  70                  75                  80  


Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr 
                85                  90                  95      


Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu 
            100                 105                 110         


Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu 
        115                 120                 125             


Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser 
    130                 135                 140                 


Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile 
145                 150                 155                 160 


Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro 
                165                 170                 175     


Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly 
            180                 185                 190         


Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg 
        195                 200                 205             


Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr 
    210                 215                 220                 


Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln 
225                 230                 235                 240 


Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr 
                245                 250                 255     


Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp 
            260                 265                 270         


Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu 
        275                 280                 285             


Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala 
    290                 295                 300                 


Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu Gly Thr Asn 
305                 310                 315                 320 


Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu Ser Ile Ser 
                325                 330                 335     


Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            340                 345         


<210>  94
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  94

Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp Leu Leu Asp Ser Gln Asp 
1               5                   10                  15      


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
            20                  25                  30          


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
        35                  40                  45              


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
    50                  55                  60                  


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
65                  70                  75                  80  


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
                85                  90                  95      


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
            100                 105                 110         


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
        115                 120                 125             


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
    130                 135                 140                 


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
145                 150                 155                 160 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
                165                 170                 175     


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
            180                 185                 190         


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
        195                 200                 205             


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu Val Asn 
    210                 215                 220                 


Lys Ser Gly Gln Ser Leu Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile 
225                 230                 235                 240 


Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala 
                245                 250                 255     


Thr Val Lys Asp Phe Glu Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala 
            260                 265                 270         


Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr 
        275                 280                 285             


Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu Gly Thr Asn Gly His His 
    290                 295                 300                 


Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu Ser Ile Ser Asp Leu Gln 
305                 310                 315                 320 


Gln Gly Arg Asp Ile Thr Arg Leu 
                325             


<210>  95
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  95

Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp Leu Leu Asp Ser Gln Asp 
1               5                   10                  15      


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
            20                  25                  30          


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
        35                  40                  45              


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
    50                  55                  60                  


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
65                  70                  75                  80  


Lys Glu Ile Lys Glu Val Ala Ala Ala Ala His Leu Glu Lys Gly His 
                85                  90                  95      


Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro 
            100                 105                 110         


Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg 
        115                 120                 125             


Asn Lys Lys Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn 
    130                 135                 140                 


Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu 
145                 150                 155                 160 


Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu 
                165                 170                 175     


Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser 
            180                 185                 190         


Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu 
        195                 200                 205             


Ile Ser Ala Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu 
    210                 215                 220         


<210>  96
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  96

Asp Arg Glu Lys Lys Pro Arg Gln Thr Glu Gly Lys Ala Glu Phe Ala 
1               5                   10                  15      


Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn 
            20                  25                  30          


Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro 
        35                  40                  45              


Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu 
    50                  55                  60                  


Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu 
65                  70                  75                  80  


Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp 
                85                  90                  95      


Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn 
            100                 105                 110         


Lys Pro Gly Gln Leu 
        115         


<210>  97
<211>  86
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PAG1 intracellular domain

<400>  97

Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp Leu Leu Asp Ser Gln Asp 
1               5                   10                  15      


Ser Thr Gly Lys Pro Lys Cys His Gln Ser Arg Glu Leu Pro Arg Ile 
            20                  25                  30          


Pro Pro Glu Ser Ala Val Asp Thr Met Leu Thr Ala Arg Ser Val Asp 
        35                  40                  45              


Gly Asp Gln Gly Leu Gly Met Glu Gly Pro Tyr Glu Val Leu Lys Asp 
    50                  55                  60                  


Ser Ser Ser Gln Glu Asn Met Val Glu Asp Cys Leu Tyr Glu Thr Val 
65                  70                  75                  80  


Lys Glu Ile Lys Glu Val 
                85      


<210>  98
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 epsilon intracellular domain

<400>  98

Lys Asn Arg Lys Ala Lys Ala Lys Pro Val Thr Arg Gly Ala Gly Ala 
1               5                   10                  15      


Gly Gly Arg Gln Arg Gly Gln Asn Lys Glu Arg Pro Pro Pro Val Pro 
            20                  25                  30          


Asn Pro Asp Tyr Glu Pro Ile Arg Lys Gly Gln Arg Asp Leu Tyr Ser 
        35                  40                  45              


Gly Leu Asn Gln Arg Arg Ile Gly Gly Ser Arg Ser Lys Arg Ser Arg 
    50                  55                  60                  


Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro 
65                  70                  75                  80  


Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala 
                85                  90                  95      


Tyr Arg Ser 
            


<210>  99
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-001765 PA2.1 scFv (mouse)

<400>  99
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgtccg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtccagctgc agcagtctgg acctgagctg      420

gtgaagcctg gggcttcagt gaggatatcc tgcaaggctt ctggctacac cttcacaagt      480

taccatatac attgggtgaa gcagaggcct ggacagggac ttgagtggat tggatggatt      540

tatcctggaa atgttaatac tgagtacaat gagaagttca agggcaaggc cacactgact      600

gcagacaaat cgtccagcac agcctacatg cacctcagca gcctgacctc tgaggactct      660

gcggtctatt tctgtgccag agaggagatt acctatgcta tggactactg gggtcaagga      720

acctcagtca ccgtgtcctc a                                                741


<210>  100
<211>  704
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2106 (NY-ESO-1 ScFv, CD8 hinge and TM, PAG1 ICD)

<400>  100

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
        275                 280                 285             


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
    290                 295                 300                 


Val Ile Thr Leu Tyr Cys Asn His Asp Arg Glu Lys Lys Pro Arg Gln 
305                 310                 315                 320 


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
                325                 330                 335     


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
            340                 345                 350         


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
        355                 360                 365             


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
    370                 375                 380                 


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
385                 390                 395                 400 


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
                405                 410                 415     


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
            420                 425                 430         


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
        435                 440                 445             


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
    450                 455                 460                 


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
465                 470                 475                 480 


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
                485                 490                 495     


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
            500                 505                 510         


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
        515                 520                 525             


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
    530                 535                 540                 


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
545                 550                 555                 560 


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
                565                 570                 575     


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
            580                 585                 590         


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
        595                 600                 605             


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
    610                 615                 620                 


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
625                 630                 635                 640 


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
                645                 650                 655     


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
            660                 665                 670         


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
        675                 680                 685             


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
    690                 695                 700                 


<210>  101
<211>  2115
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2106 (NY-ESO-1 ScFv, CD8 hinge and TM, PAG1 ICD)

<400>  101
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcaaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      780

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      840

ctggacttcg cctgtgatat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt      900

ctcctgtcac tggttatcac cctttactgc aaccacgaca gggaaaagaa gccgcgacag      960

catagtgggg accatgagaa cctgatgaac gtgccttcag acaaggagat gttcagccgt     1020

tcagttacta gcctggcaac agatgctcct gccagcagtg agcagaatgg ggcactcacc     1080

aatggggaca ttctttcaga ggacagtact ctgacctgca tgcagcatta cgaggaagtc     1140

cagacatcgg cctcggatct gctggattcc caggacagca cagggaaacc aaaatgtcat     1200

cagagtcggg agctgcccag aatccctccc gagagcgcag tggataccat gctcacggcg     1260

agaagtgtgg acggggacca ggggctgggg atggaagggc cctatgaagt gctcaaggac     1320

agctcctccc aagaaaacat ggtggaggac tgcttgtatg aaactgtgaa agagatcaag     1380

gaggtggctg cagctgcaca cctggagaaa ggccacagtg gcaaggcaaa atctacttct     1440

gcctcgaaag agctcccagg gccccagact gaaggcaaag ctgagtttgc tgaatatgcc     1500

tcggtggaca gaaacaaaaa atgtcgtcaa agtgttaatg tagagagtat ccttggaaat     1560

tcatgtgatc cagaagagga ggccccacca cctgtccctg ttaagcttct ggacgagaat     1620

gaaaaccttc aggagaagga agggggagag gcggaagaga gtgccacaga cacgaccagt     1680

gaaactaaca agagatttag ctcattgtca tacaagtctc gggaagaaga ccccactctc     1740

acagaagaag agatctcagc tatgtactca tcagtaaata aacctggaca gttagtgaat     1800

aaatcggggc agtcgcttac agttccggag tccacctaca cctccattca aggggaccca     1860

cagaggtcac cctcctcctg taatgatctc tatgctactg ttaaagactt cgaaaaaact     1920

ccaaacagca cacttccacc agcagggagg cccagcgagg agccagagcc tgattatgaa     1980

gcgatacaga ctctcaacag agaggaagaa aaggccaccc tggggaccaa tggccaccac     2040

ggtctcgtcc caaaggagaa cgactacgag agcataagtg acttgcagca aggcagagat     2100

attaccaggc tctag                                                      2115


<210>  102
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2107 (NY-ESO-1 ScFv, CD8 hinge, PAG1 TM and  ICD)

<400>  102

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
                245                 250                 255     


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
            260                 265                 270         


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Leu Trp 
        275                 280                 285             


Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe Leu Ile 
    290                 295                 300                 


Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln His Ser 
305                 310                 315                 320 


Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe 
                325                 330                 335     


Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu 
            340                 345                 350         


Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr 
        355                 360                 365             


Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp 
    370                 375                 380                 


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
385                 390                 395                 400 


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
                405                 410                 415     


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
            420                 425                 430         


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
        435                 440                 445             


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
    450                 455                 460                 


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
465                 470                 475                 480 


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
                485                 490                 495     


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
            500                 505                 510         


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
        515                 520                 525             


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
    530                 535                 540                 


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
545                 550                 555                 560 


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
                565                 570                 575     


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
            580                 585                 590         


Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu 
        595                 600                 605             


Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser 
    610                 615                 620                 


Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn 
625                 630                 635                 640 


Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp 
                645                 650                 655     


Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu 
            660                 665                 670         


Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu 
        675                 680                 685             


Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
    690                 695                 700         


<210>  103
<211>  2109
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2107 (NY-ESO-1 ScFv, CD8 hinge, PAG1 TM and  ICD)

<400>  103
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcaaccacga cgccagcgcc gcgaccacca acaccggcgc ccaccatcgc gtcgcagccc      780

ctgtccctgc gcccagaggc gtgccggcca gcggcggggg gcgcagtgca cacgaggggg      840

ctggacttcg cctgtgatct gtggggaagt ctggctgctg tcgccatttt cttcgtcatc      900

accttcctca tcttcctgtg ctctagttgt gacagggaaa agaagccgcg acagcatagt      960

ggggaccatg agaacctgat gaacgtgcct tcagacaagg agatgttcag ccgttcagtt     1020

actagcctgg caacagatgc tcctgccagc agtgagcaga atggggcact caccaatggg     1080

gacattcttt cagaggacag tactctgacc tgcatgcagc attacgagga agtccagaca     1140

tcggcctcgg atctgctgga ttcccaggac agcacaggga aaccaaaatg tcatcagagt     1200

cgggagctgc ccagaatccc tcccgagagc gcagtggata ccatgctcac ggcgagaagt     1260

gtggacgggg accaggggct ggggatggaa gggccctatg aagtgctcaa ggacagctcc     1320

tcccaagaaa acatggtgga ggactgcttg tatgaaactg tgaaagagat caaggaggtg     1380

gctgcagctg cacacctgga gaaaggccac agtggcaagg caaaatctac ttctgcctcg     1440

aaagagctcc cagggcccca gactgaaggc aaagctgagt ttgctgaata tgcctcggtg     1500

gacagaaaca aaaaatgtcg tcaaagtgtt aatgtagaga gtatccttgg aaattcatgt     1560

gatccagaag aggaggcccc accacctgtc cctgttaagc ttctggacga gaatgaaaac     1620

cttcaggaga aggaaggggg agaggcggaa gagagtgcca cagacacgac cagtgaaact     1680

aacaagagat ttagctcatt gtcatacaag tctcgggaag aagaccccac tctcacagaa     1740

gaagagatct cagctatgta ctcatcagta aataaacctg gacagttagt gaataaatcg     1800

gggcagtcgc ttacagttcc ggagtccacc tacacctcca ttcaagggga cccacagagg     1860

tcaccctcct cctgtaatga tctctatgct actgttaaag acttcgaaaa aactccaaac     1920

agcacacttc caccagcagg gaggcccagc gaggagccag agcctgatta tgaagcgata     1980

cagactctca acagagagga agaaaaggcc accctgggga ccaatggcca ccacggtctc     2040

gtcccaaagg agaacgacta cgagagcata agtgacttgc agcaaggcag agatattacc     2100

aggctctag                                                             2109


<210>  104
<211>  672
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2222 (NY-ESO-1 ScFv, PAG1 hinge, TM and ICD)

<400>  104

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
                245                 250                 255     


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
            260                 265                 270         


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
        275                 280                 285             


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
    290                 295                 300                 


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
305                 310                 315                 320 


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
                325                 330                 335     


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
            340                 345                 350         


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
        355                 360                 365             


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
    370                 375                 380                 


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
385                 390                 395                 400 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
                405                 410                 415     


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
            420                 425                 430         


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
        435                 440                 445             


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
    450                 455                 460                 


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
465                 470                 475                 480 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
                485                 490                 495     


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
            500                 505                 510         


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
        515                 520                 525             


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
    530                 535                 540                 


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
545                 550                 555                 560 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
                565                 570                 575     


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
            580                 585                 590         


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
        595                 600                 605             


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
    610                 615                 620                 


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
625                 630                 635                 640 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
                645                 650                 655     


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
            660                 665                 670         


<210>  105
<211>  2019
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2222 (NY-ESO-1 ScFv, PAG1 hinge, TM and ICD)

<400>  105
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcagggcccg cggggagcct gctgggcagc ggacagatgc agatcaccct gtggggaagt      780

ctggctgctg tcgccatttt cttcgtcatc accttcctca tcttcctgtg ctctagttgt      840

gacagggaaa agaagccgcg acagcatagt ggggaccatg agaacctgat gaacgtgcct      900

tcagacaagg agatgttcag ccgttcagtt actagcctgg caacagatgc tcctgccagc      960

agtgagcaga atggggcact caccaatggg gacattcttt cagaggacag tactctgacc     1020

tgcatgcagc attacgagga agtccagaca tcggcctcgg atctgctgga ttcccaggac     1080

agcacaggga aaccaaaatg tcatcagagt cgggagctgc ccagaatccc tcccgagagc     1140

gcagtggata ccatgctcac ggcgagaagt gtggacgggg accaggggct ggggatggaa     1200

gggccctatg aagtgctcaa ggacagctcc tcccaagaaa acatggtgga ggactgcttg     1260

tatgaaactg tgaaagagat caaggaggtg gctgcagctg cacacctgga gaaaggccac     1320

agtggcaagg caaaatctac ttctgcctcg aaagagctcc cagggcccca gactgaaggc     1380

aaagctgagt ttgctgaata tgcctcggtg gacagaaaca aaaaatgtcg tcaaagtgtt     1440

aatgtagaga gtatccttgg aaattcatgt gatccagaag aggaggcccc accacctgtc     1500

cctgttaagc ttctggacga gaatgaaaac cttcaggaga aggaaggggg agaggcggaa     1560

gagagtgcca cagacacgac cagtgaaact aacaagagat ttagctcatt gtcatacaag     1620

tctcgggaag aagaccccac tctcacagaa gaagagatct cagctatgta ctcatcagta     1680

aataaacctg gacagttagt gaataaatcg gggcagtcgc ttacagttcc ggagtccacc     1740

tacacctcca ttcaagggga cccacagagg tcaccctcct cctgtaatga tctctatgct     1800

actgttaaag acttcgaaaa aactccaaac agcacacttc caccagcagg gaggcccagc     1860

gaggagccag agcctgatta tgaagcgata cagactctca acagagagga agaaaaggcc     1920

accctgggga ccaatggcca ccacggtctc gtcccaaagg agaacgacta cgagagcata     1980

agtgacttgc agcaaggcag agatattacc aggctctag                            2019


<210>  106
<211>  736
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2223 (NY-ESO-1 ScFv, LILRB1/PAG1 hinge, PAG1 TM and ICD)

<400>  106

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Gly Pro Ala Gly Ser Leu Leu Gly Ser Gly Gln Met Gln Ile Thr 
305                 310                 315                 320 


Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr Phe 
                325                 330                 335     


Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg Gln 
            340                 345                 350         


His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu 
        355                 360                 365             


Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser 
    370                 375                 380                 


Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp 
385                 390                 395                 400 


Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala 
                405                 410                 415     


Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His 
            420                 425                 430         


Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr 
        435                 440                 445             


Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu 
    450                 455                 460                 


Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val 
465                 470                 475                 480 


Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala 
                485                 490                 495     


Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser 
            500                 505                 510         


Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe 
        515                 520                 525             


Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val 
    530                 535                 540                 


Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala 
545                 550                 555                 560 


Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln 
                565                 570                 575     


Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser 
            580                 585                 590         


Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu 
        595                 600                 605             


Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val 
    610                 615                 620                 


Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val 
625                 630                 635                 640 


Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro 
                645                 650                 655     


Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr 
            660                 665                 670         


Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu 
        675                 680                 685             


Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
    690                 695                 700                 


Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp 
705                 710                 715                 720 


Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
                725                 730                 735     


<210>  107
<211>  2211
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2223 (NY-ESO-1 ScFv, LILRB1/PAG1 hinge, PAG1 TM and ICD)

<400>  107
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgggcc cgcggggagc ctgctgggca gcggacagat gcagatcacc      960

ctgtggggaa gtctggctgc tgtcgccatt ttcttcgtca tcaccttcct catcttcctg     1020

tgctctagtt gtgacaggga aaagaagccg cgacagcata gtggggacca tgagaacctg     1080

atgaacgtgc cttcagacaa ggagatgttc agccgttcag ttactagcct ggcaacagat     1140

gctcctgcca gcagtgagca gaatggggca ctcaccaatg gggacattct ttcagaggac     1200

agtactctga cctgcatgca gcattacgag gaagtccaga catcggcctc ggatctgctg     1260

gattcccagg acagcacagg gaaaccaaaa tgtcatcaga gtcgggagct gcccagaatc     1320

cctcccgaga gcgcagtgga taccatgctc acggcgagaa gtgtggacgg ggaccagggg     1380

ctggggatgg aagggcccta tgaagtgctc aaggacagct cctcccaaga aaacatggtg     1440

gaggactgct tgtatgaaac tgtgaaagag atcaaggagg tggctgcagc tgcacacctg     1500

gagaaaggcc acagtggcaa ggcaaaatct acttctgcct cgaaagagct cccagggccc     1560

cagactgaag gcaaagctga gtttgctgaa tatgcctcgg tggacagaaa caaaaaatgt     1620

cgtcaaagtg ttaatgtaga gagtatcctt ggaaattcat gtgatccaga agaggaggcc     1680

ccaccacctg tccctgttaa gcttctggac gagaatgaaa accttcagga gaaggaaggg     1740

ggagaggcgg aagagagtgc cacagacacg accagtgaaa ctaacaagag atttagctca     1800

ttgtcataca agtctcggga agaagacccc actctcacag aagaagagat ctcagctatg     1860

tactcatcag taaataaacc tggacagtta gtgaataaat cggggcagtc gcttacagtt     1920

ccggagtcca cctacacctc cattcaaggg gacccacaga ggtcaccctc ctcctgtaat     1980

gatctctatg ctactgttaa agacttcgaa aaaactccaa acagcacact tccaccagca     2040

gggaggccca gcgaggagcc agagcctgat tatgaagcga tacagactct caacagagag     2100

gaagaaaagg ccaccctggg gaccaatggc caccacggtc tcgtcccaaa ggagaacgac     2160

tacgagagca taagtgactt gcagcaaggc agagatatta ccaggctcta g              2211


<210>  108
<211>  721
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2224 (NY-ESO-1 ScFV, LILRB1 hinge, PAG1 TM and ICD)

<400>  108

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Leu Trp Gly Ser Leu Ala Ala Val Ala Ile Phe Phe Val Ile Thr 
305                 310                 315                 320 


Phe Leu Ile Phe Leu Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro Arg 
                325                 330                 335     


Gln His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys 
            340                 345                 350         


Glu Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala 
        355                 360                 365             


Ser Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu 
    370                 375                 380                 


Asp Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser 
385                 390                 395                 400 


Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys 
                405                 410                 415     


His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp 
            420                 425                 430         


Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met 
        435                 440                 445             


Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met 
    450                 455                 460                 


Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala 
465                 470                 475                 480 


Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr 
                485                 490                 495     


Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu 
            500                 505                 510         


Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser 
        515                 520                 525             


Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu 
    530                 535                 540                 


Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu 
545                 550                 555                 560 


Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr 
                565                 570                 575     


Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu 
            580                 585                 590         


Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser 
        595                 600                 605             


Val Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr 
    610                 615                 620                 


Val Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser 
625                 630                 635                 640 


Pro Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys 
                645                 650                 655     


Thr Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro 
            660                 665                 670         


Glu Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys 
        675                 680                 685             


Ala Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn 
    690                 695                 700                 


Asp Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg 
705                 710                 715                 720 


Leu 
    


<210>  109
<211>  2166
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2224 (NY-ESO-1 ScFV, LILRB1 hinge, PAG1 TM and ICD)

<400>  109
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttctgtg gggaagtctg gctgctgtcg ccattttctt cgtcatcacc      960

ttcctcatct tcctgtgctc tagttgtgac agggaaaaga agccgcgaca gcatagtggg     1020

gaccatgaga acctgatgaa cgtgccttca gacaaggaga tgttcagccg ttcagttact     1080

agcctggcaa cagatgctcc tgccagcagt gagcagaatg gggcactcac caatggggac     1140

attctttcag aggacagtac tctgacctgc atgcagcatt acgaggaagt ccagacatcg     1200

gcctcggatc tgctggattc ccaggacagc acagggaaac caaaatgtca tcagagtcgg     1260

gagctgccca gaatccctcc cgagagcgca gtggatacca tgctcacggc gagaagtgtg     1320

gacggggacc aggggctggg gatggaaggg ccctatgaag tgctcaagga cagctcctcc     1380

caagaaaaca tggtggagga ctgcttgtat gaaactgtga aagagatcaa ggaggtggct     1440

gcagctgcac acctggagaa aggccacagt ggcaaggcaa aatctacttc tgcctcgaaa     1500

gagctcccag ggccccagac tgaaggcaaa gctgagtttg ctgaatatgc ctcggtggac     1560

agaaacaaaa aatgtcgtca aagtgttaat gtagagagta tccttggaaa ttcatgtgat     1620

ccagaagagg aggccccacc acctgtccct gttaagcttc tggacgagaa tgaaaacctt     1680

caggagaagg aagggggaga ggcggaagag agtgccacag acacgaccag tgaaactaac     1740

aagagattta gctcattgtc atacaagtct cgggaagaag accccactct cacagaagaa     1800

gagatctcag ctatgtactc atcagtaaat aaacctggac agttagtgaa taaatcgggg     1860

cagtcgctta cagttccgga gtccacctac acctccattc aaggggaccc acagaggtca     1920

ccctcctcct gtaatgatct ctatgctact gttaaagact tcgaaaaaac tccaaacagc     1980

acacttccac cagcagggag gcccagcgag gagccagagc ctgattatga agcgatacag     2040

actctcaaca gagaggaaga aaaggccacc ctggggacca atggccacca cggtctcgtc     2100

ccaaaggaga acgactacga gagcataagt gacttgcagc aaggcagaga tattaccagg     2160

ctctag                                                                2166


<210>  110
<211>  722
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2225 (NY-ESO-1 ScFv LILRB1 hinge and TM, PAG1 [37-432] ICD)

<400>  110

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Cys Ser Ser Cys Asp Arg Glu Lys Lys Pro 
                325                 330                 335     


Arg Gln His Ser Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp 
            340                 345                 350         


Lys Glu Met Phe Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro 
        355                 360                 365             


Ala Ser Ser Glu Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser 
    370                 375                 380                 


Glu Asp Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr 
385                 390                 395                 400 


Ser Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys 
                405                 410                 415     


Cys His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val 
            420                 425                 430         


Asp Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly 
        435                 440                 445             


Met Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn 
    450                 455                 460                 


Met Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val 
465                 470                 475                 480 


Ala Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser 
                485                 490                 495     


Thr Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala 
            500                 505                 510         


Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln 
        515                 520                 525             


Ser Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu 
    530                 535                 540                 


Glu Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn 
545                 550                 555                 560 


Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr 
                565                 570                 575     


Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg 
            580                 585                 590         


Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser 
        595                 600                 605             


Ser Val Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu 
    610                 615                 620                 


Thr Val Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg 
625                 630                 635                 640 


Ser Pro Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu 
                645                 650                 655     


Lys Thr Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu 
            660                 665                 670         


Pro Glu Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu 
        675                 680                 685             


Lys Ala Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu 
    690                 695                 700                 


Asn Asp Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr 
705                 710                 715                 720 


Arg Leu 
        


<210>  111
<211>  2169
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2225 (NY-ESO-1 ScFv LILRB1 hinge and TM, PAG1 [37-432] ICD)

<400>  111
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatctg ctctagttgt gacagggaaa agaagccgcg acagcatagt     1020

ggggaccatg agaacctgat gaacgtgcct tcagacaagg agatgttcag ccgttcagtt     1080

actagcctgg caacagatgc tcctgccagc agtgagcaga atggggcact caccaatggg     1140

gacattcttt cagaggacag tactctgacc tgcatgcagc attacgagga agtccagaca     1200

tcggcctcgg atctgctgga ttcccaggac agcacaggga aaccaaaatg tcatcagagt     1260

cgggagctgc ccagaatccc tcccgagagc gcagtggata ccatgctcac ggcgagaagt     1320

gtggacgggg accaggggct ggggatggaa gggccctatg aagtgctcaa ggacagctcc     1380

tcccaagaaa acatggtgga ggactgcttg tatgaaactg tgaaagagat caaggaggtg     1440

gctgcagctg cacacctgga gaaaggccac agtggcaagg caaaatctac ttctgcctcg     1500

aaagagctcc cagggcccca gactgaaggc aaagctgagt ttgctgaata tgcctcggtg     1560

gacagaaaca aaaaatgtcg tcaaagtgtt aatgtagaga gtatccttgg aaattcatgt     1620

gatccagaag aggaggcccc accacctgtc cctgttaagc ttctggacga gaatgaaaac     1680

cttcaggaga aggaaggggg agaggcggaa gagagtgcca cagacacgac cagtgaaact     1740

aacaagagat ttagctcatt gtcatacaag tctcgggaag aagaccccac tctcacagaa     1800

gaagagatct cagctatgta ctcatcagta aataaacctg gacagttagt gaataaatcg     1860

gggcagtcgc ttacagttcc ggagtccacc tacacctcca ttcaagggga cccacagagg     1920

tcaccctcct cctgtaatga tctctatgct actgttaaag acttcgaaaa aactccaaac     1980

agcacacttc caccagcagg gaggcccagc gaggagccag agcctgatta tgaagcgata     2040

cagactctca acagagagga agaaaaggcc accctgggga ccaatggcca ccacggtctc     2100

gtcccaaagg agaacgacta cgagagcata agtgacttgc agcaaggcag agatattacc     2160

aggctctag                                                             2169


<210>  112
<211>  718
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2226 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-432] ICD)

<400>  112

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Gln His Ser 
                325                 330                 335     


Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe 
            340                 345                 350         


Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu 
        355                 360                 365             


Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr 
    370                 375                 380                 


Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp 
385                 390                 395                 400 


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
                405                 410                 415     


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
            420                 425                 430         


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
        435                 440                 445             


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
    450                 455                 460                 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
465                 470                 475                 480 


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
                485                 490                 495     


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
            500                 505                 510         


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
        515                 520                 525             


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
    530                 535                 540                 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
545                 550                 555                 560 


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
                565                 570                 575     


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
            580                 585                 590         


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
        595                 600                 605             


Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu 
    610                 615                 620                 


Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser 
625                 630                 635                 640 


Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn 
                645                 650                 655     


Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp 
            660                 665                 670         


Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu 
        675                 680                 685             


Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu 
    690                 695                 700                 


Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
705                 710                 715             


<210>  113
<211>  2157
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2226 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-432] ICD)

<400>  113
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac agcatagtgg ggaccatgag     1020

aacctgatga acgtgccttc agacaaggag atgttcagcc gttcagttac tagcctggca     1080

acagatgctc ctgccagcag tgagcagaat ggggcactca ccaatgggga cattctttca     1140

gaggacagta ctctgacctg catgcagcat tacgaggaag tccagacatc ggcctcggat     1200

ctgctggatt cccaggacag cacagggaaa ccaaaatgtc atcagagtcg ggagctgccc     1260

agaatccctc ccgagagcgc agtggatacc atgctcacgg cgagaagtgt ggacggggac     1320

caggggctgg ggatggaagg gccctatgaa gtgctcaagg acagctcctc ccaagaaaac     1380

atggtggagg actgcttgta tgaaactgtg aaagagatca aggaggtggc tgcagctgca     1440

cacctggaga aaggccacag tggcaaggca aaatctactt ctgcctcgaa agagctccca     1500

gggccccaga ctgaaggcaa agctgagttt gctgaatatg cctcggtgga cagaaacaaa     1560

aaatgtcgtc aaagtgttaa tgtagagagt atccttggaa attcatgtga tccagaagag     1620

gaggccccac cacctgtccc tgttaagctt ctggacgaga atgaaaacct tcaggagaag     1680

gaagggggag aggcggaaga gagtgccaca gacacgacca gtgaaactaa caagagattt     1740

agctcattgt catacaagtc tcgggaagaa gaccccactc tcacagaaga agagatctca     1800

gctatgtact catcagtaaa taaacctgga cagttagtga ataaatcggg gcagtcgctt     1860

acagttccgg agtccaccta cacctccatt caaggggacc cacagaggtc accctcctcc     1920

tgtaatgatc tctatgctac tgttaaagac ttcgaaaaaa ctccaaacag cacacttcca     1980

ccagcaggga ggcccagcga ggagccagag cctgattatg aagcgataca gactctcaac     2040

agagaggaag aaaaggccac cctggggacc aatggccacc acggtctcgt cccaaaggag     2100

aacgactacg agagcataag tgacttgcag caaggcagag atattaccag gctctag        2157


<210>  114
<211>  686
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2481 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-400] ICD)

<400>  114

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Gln His Ser 
                325                 330                 335     


Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe 
            340                 345                 350         


Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu 
        355                 360                 365             


Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr 
    370                 375                 380                 


Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp 
385                 390                 395                 400 


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
                405                 410                 415     


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
            420                 425                 430         


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
        435                 440                 445             


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
    450                 455                 460                 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
465                 470                 475                 480 


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
                485                 490                 495     


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
            500                 505                 510         


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
        515                 520                 525             


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
    530                 535                 540                 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
545                 550                 555                 560 


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
                565                 570                 575     


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
            580                 585                 590         


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
        595                 600                 605             


Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu 
    610                 615                 620                 


Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser 
625                 630                 635                 640 


Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn 
                645                 650                 655     


Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp 
            660                 665                 670         


Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala 
        675                 680                 685     


<210>  115
<211>  2061
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2481 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-400] ICD)

<400>  115
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac agcatagtgg ggaccatgag     1020

aacctgatga acgtgccttc agacaaggag atgttcagcc gttcagttac tagcctggca     1080

acagatgctc ctgccagcag tgagcagaat ggggcactca ccaatgggga cattctttca     1140

gaggacagta ctctgacctg catgcagcat tacgaggaag tccagacatc ggcctcggat     1200

ctgctggatt cccaggacag cacagggaaa ccaaaatgtc atcagagtcg ggagctgccc     1260

agaatccctc ccgagagcgc agtggatacc atgctcacgg cgagaagtgt ggacggggac     1320

caggggctgg ggatggaagg gccctatgaa gtgctcaagg acagctcctc ccaagaaaac     1380

atggtggagg actgcttgta tgaaactgtg aaagagatca aggaggtggc tgcagctgca     1440

cacctggaga aaggccacag tggcaaggca aaatctactt ctgcctcgaa agagctccca     1500

gggccccaga ctgaaggcaa agctgagttt gctgaatatg cctcggtgga cagaaacaaa     1560

aaatgtcgtc aaagtgttaa tgtagagagt atccttggaa attcatgtga tccagaagag     1620

gaggccccac cacctgtccc tgttaagctt ctggacgaga atgaaaacct tcaggagaag     1680

gaagggggag aggcggaaga gagtgccaca gacacgacca gtgaaactaa caagagattt     1740

agctcattgt catacaagtc tcgggaagaa gaccccactc tcacagaaga agagatctca     1800

gctatgtact catcagtaaa taaacctgga cagttagtga ataaatcggg gcagtcgctt     1860

acagttccgg agtccaccta cacctccatt caaggggacc cacagaggtc accctcctcc     1920

tgtaatgatc tctatgctac tgttaaagac ttcgaaaaaa ctccaaacag cacacttcca     1980

ccagcaggga ggcccagcga ggagccagag cctgattatg aagcgataca gactctcaac     2040

agagaggaag aaaaggccta g                                               2061


<210>  116
<211>  657
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2482 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-371 ICD)

<400>  116

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Gln His Ser 
                325                 330                 335     


Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe 
            340                 345                 350         


Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu 
        355                 360                 365             


Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr 
    370                 375                 380                 


Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp 
385                 390                 395                 400 


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
                405                 410                 415     


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
            420                 425                 430         


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
        435                 440                 445             


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
    450                 455                 460                 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
465                 470                 475                 480 


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
                485                 490                 495     


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
            500                 505                 510         


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
        515                 520                 525             


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
    530                 535                 540                 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
545                 550                 555                 560 


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
                565                 570                 575     


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
            580                 585                 590         


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
        595                 600                 605             


Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu 
    610                 615                 620                 


Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser 
625                 630                 635                 640 


Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn 
                645                 650                 655     


Ser 
    


<210>  117
<211>  1974
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2482 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-371 ICD)

<400>  117
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac agcatagtgg ggaccatgag     1020

aacctgatga acgtgccttc agacaaggag atgttcagcc gttcagttac tagcctggca     1080

acagatgctc ctgccagcag tgagcagaat ggggcactca ccaatgggga cattctttca     1140

gaggacagta ctctgacctg catgcagcat tacgaggaag tccagacatc ggcctcggat     1200

ctgctggatt cccaggacag cacagggaaa ccaaaatgtc atcagagtcg ggagctgccc     1260

agaatccctc ccgagagcgc agtggatacc atgctcacgg cgagaagtgt ggacggggac     1320

caggggctgg ggatggaagg gccctatgaa gtgctcaagg acagctcctc ccaagaaaac     1380

atggtggagg actgcttgta tgaaactgtg aaagagatca aggaggtggc tgcagctgca     1440

cacctggaga aaggccacag tggcaaggca aaatctactt ctgcctcgaa agagctccca     1500

gggccccaga ctgaaggcaa agctgagttt gctgaatatg cctcggtgga cagaaacaaa     1560

aaatgtcgtc aaagtgttaa tgtagagagt atccttggaa attcatgtga tccagaagag     1620

gaggccccac cacctgtccc tgttaagctt ctggacgaga atgaaaacct tcaggagaag     1680

gaagggggag aggcggaaga gagtgccaca gacacgacca gtgaaactaa caagagattt     1740

agctcattgt catacaagtc tcgggaagaa gaccccactc tcacagaaga agagatctca     1800

gctatgtact catcagtaaa taaacctgga cagttagtga ataaatcggg gcagtcgctt     1860

acagttccgg agtccaccta cacctccatt caaggggacc cacagaggtc accctcctcc     1920

tgtaatgatc tctatgctac tgttaaagac ttcgaaaaaa ctccaaacag ctag           1974


<210>  118
<211>  612
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2483 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-326] ICD)

<400>  118

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Gln His Ser 
                325                 330                 335     


Gly Asp His Glu Asn Leu Met Asn Val Pro Ser Asp Lys Glu Met Phe 
            340                 345                 350         


Ser Arg Ser Val Thr Ser Leu Ala Thr Asp Ala Pro Ala Ser Ser Glu 
        355                 360                 365             


Gln Asn Gly Ala Leu Thr Asn Gly Asp Ile Leu Ser Glu Asp Ser Thr 
    370                 375                 380                 


Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser Ala Ser Asp 
385                 390                 395                 400 


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
                405                 410                 415     


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
            420                 425                 430         


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
        435                 440                 445             


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
    450                 455                 460                 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
465                 470                 475                 480 


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
                485                 490                 495     


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
            500                 505                 510         


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
        515                 520                 525             


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
    530                 535                 540                 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
545                 550                 555                 560 


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
                565                 570                 575     


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
            580                 585                 590         


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
        595                 600                 605             


Pro Gly Gln Leu 
    610         


<210>  119
<211>  1839
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2483 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[41-326] ICD)

<400>  119
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac agcatagtgg ggaccatgag     1020

aacctgatga acgtgccttc agacaaggag atgttcagcc gttcagttac tagcctggca     1080

acagatgctc ctgccagcag tgagcagaat ggggcactca ccaatgggga cattctttca     1140

gaggacagta ctctgacctg catgcagcat tacgaggaag tccagacatc ggcctcggat     1200

ctgctggatt cccaggacag cacagggaaa ccaaaatgtc atcagagtcg ggagctgccc     1260

agaatccctc ccgagagcgc agtggatacc atgctcacgg cgagaagtgt ggacggggac     1320

caggggctgg ggatggaagg gccctatgaa gtgctcaagg acagctcctc ccaagaaaac     1380

atggtggagg actgcttgta tgaaactgtg aaagagatca aggaggtggc tgcagctgca     1440

cacctggaga aaggccacag tggcaaggca aaatctactt ctgcctcgaa agagctccca     1500

gggccccaga ctgaaggcaa agctgagttt gctgaatatg cctcggtgga cagaaacaaa     1560

aaatgtcgtc aaagtgttaa tgtagagagt atccttggaa attcatgtga tccagaagag     1620

gaggccccac cacctgtccc tgttaagctt ctggacgaga atgaaaacct tcaggagaag     1680

gaagggggag aggcggaaga gagtgccaca gacacgacca gtgaaactaa caagagattt     1740

agctcattgt catacaagtc tcgggaagaa gaccccactc tcacagaaga agagatctca     1800

gctatgtact catcagtaaa taaacctgga cagttatag                            1839


<210>  120
<211>  673
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2484 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[93-432] ICD)

<400>  120

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Leu Ser Glu 
                325                 330                 335     


Asp Ser Thr Leu Thr Cys Met Gln His Tyr Glu Glu Val Gln Thr Ser 
            340                 345                 350         


Ala Ser Asp Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys 
        355                 360                 365             


His Gln Ser Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp 
    370                 375                 380                 


Thr Met Leu Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met 
385                 390                 395                 400 


Glu Gly Pro Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met 
                405                 410                 415     


Val Glu Asp Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala 
            420                 425                 430         


Ala Ala Ala His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr 
        435                 440                 445             


Ser Ala Ser Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu 
    450                 455                 460                 


Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser 
465                 470                 475                 480 


Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu 
                485                 490                 495     


Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu 
            500                 505                 510         


Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr 
        515                 520                 525             


Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu 
    530                 535                 540                 


Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser 
545                 550                 555                 560 


Val Asn Lys Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr 
                565                 570                 575     


Val Pro Glu Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser 
            580                 585                 590         


Pro Ser Ser Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys 
        595                 600                 605             


Thr Pro Asn Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro 
    610                 615                 620                 


Glu Pro Asp Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys 
625                 630                 635                 640 


Ala Thr Leu Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn 
                645                 650                 655     


Asp Tyr Glu Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg 
            660                 665                 670         


Leu 
    


<210>  121
<211>  2022
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2484 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[93-432] ICD)

<400>  121
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac tttcagagga cagtactctg     1020

acctgcatgc agcattacga ggaagtccag acatcggcct cggatctgct ggattcccag     1080

gacagcacag ggaaaccaaa atgtcatcag agtcgggagc tgcccagaat ccctcccgag     1140

agcgcagtgg ataccatgct cacggcgaga agtgtggacg gggaccaggg gctggggatg     1200

gaagggccct atgaagtgct caaggacagc tcctcccaag aaaacatggt ggaggactgc     1260

ttgtatgaaa ctgtgaaaga gatcaaggag gtggctgcag ctgcacacct ggagaaaggc     1320

cacagtggca aggcaaaatc tacttctgcc tcgaaagagc tcccagggcc ccagactgaa     1380

ggcaaagctg agtttgctga atatgcctcg gtggacagaa acaaaaaatg tcgtcaaagt     1440

gttaatgtag agagtatcct tggaaattca tgtgatccag aagaggaggc cccaccacct     1500

gtccctgtta agcttctgga cgagaatgaa aaccttcagg agaaggaagg gggagaggcg     1560

gaagagagtg ccacagacac gaccagtgaa actaacaaga gatttagctc attgtcatac     1620

aagtctcggg aagaagaccc cactctcaca gaagaagaga tctcagctat gtactcatca     1680

gtaaataaac ctggacagtt agtgaataaa tcggggcagt cgcttacagt tccggagtcc     1740

acctacacct ccattcaagg ggacccacag aggtcaccct cctcctgtaa tgatctctat     1800

gctactgtta aagacttcga aaaaactcca aacagcacac ttccaccagc agggaggccc     1860

agcgaggagc cagagcctga ttatgaagcg atacagactc tcaacagaga ggaagaaaag     1920

gccaccctgg ggaccaatgg ccaccacggt ctcgtcccaa aggagaacga ctacgagagc     1980

ataagtgact tgcagcaagg cagagatatt accaggctct ag                        2022


<210>  122
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2485 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-432] ICD)

<400>  122

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp 
                325                 330                 335     


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
            340                 345                 350         


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
        355                 360                 365             


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
    370                 375                 380                 


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
385                 390                 395                 400 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
                405                 410                 415     


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
            420                 425                 430         


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
        435                 440                 445             


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
    450                 455                 460                 


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
465                 470                 475                 480 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
                485                 490                 495     


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
            500                 505                 510         


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
        515                 520                 525             


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
    530                 535                 540                 


Pro Gly Gln Leu Val Asn Lys Ser Gly Gln Ser Leu Thr Val Pro Glu 
545                 550                 555                 560 


Ser Thr Tyr Thr Ser Ile Gln Gly Asp Pro Gln Arg Ser Pro Ser Ser 
                565                 570                 575     


Cys Asn Asp Leu Tyr Ala Thr Val Lys Asp Phe Glu Lys Thr Pro Asn 
            580                 585                 590         


Ser Thr Leu Pro Pro Ala Gly Arg Pro Ser Glu Glu Pro Glu Pro Asp 
        595                 600                 605             


Tyr Glu Ala Ile Gln Thr Leu Asn Arg Glu Glu Glu Lys Ala Thr Leu 
    610                 615                 620                 


Gly Thr Asn Gly His His Gly Leu Val Pro Lys Glu Asn Asp Tyr Glu 
625                 630                 635                 640 


Ser Ile Ser Asp Leu Gln Gln Gly Arg Asp Ile Thr Arg Leu 
                645                 650                 


<210>  123
<211>  1965
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2485 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-432] ICD)

<400>  123
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgag cctcggatct gctggattcc     1020

caggacagca cagggaaacc aaaatgtcat cagagtcggg agctgcccag aatccctccc     1080

gagagcgcag tggataccat gctcacggcg agaagtgtgg acggggacca ggggctgggg     1140

atggaagggc cctatgaagt gctcaaggac agctcctccc aagaaaacat ggtggaggac     1200

tgcttgtatg aaactgtgaa agagatcaag gaggtggctg cagctgcaca cctggagaaa     1260

ggccacagtg gcaaggcaaa atctacttct gcctcgaaag agctcccagg gccccagact     1320

gaaggcaaag ctgagtttgc tgaatatgcc tcggtggaca gaaacaaaaa atgtcgtcaa     1380

agtgttaatg tagagagtat ccttggaaat tcatgtgatc cagaagagga ggccccacca     1440

cctgtccctg ttaagcttct ggacgagaat gaaaaccttc aggagaagga agggggagag     1500

gcggaagaga gtgccacaga cacgaccagt gaaactaaca agagatttag ctcattgtca     1560

tacaagtctc gggaagaaga ccccactctc acagaagaag agatctcagc tatgtactca     1620

tcagtaaata aacctggaca gttagtgaat aaatcggggc agtcgcttac agttccggag     1680

tccacctaca cctccattca aggggaccca cagaggtcac cctcctcctg taatgatctc     1740

tatgctactg ttaaagactt cgaaaaaact ccaaacagca cacttccacc agcagggagg     1800

cccagcgagg agccagagcc tgattatgaa gcgatacaga ctctcaacag agaggaagaa     1860

aaggccaccc tggggaccaa tggccaccac ggtctcgtcc caaaggagaa cgactacgag     1920

agcataagtg acttgcagca aggcagagat attaccaggc tctag                     1965


<210>  124
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2938 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] ICD)

<400>  124

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp 
                325                 330                 335     


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
            340                 345                 350         


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
        355                 360                 365             


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
    370                 375                 380                 


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
385                 390                 395                 400 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
                405                 410                 415     


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
            420                 425                 430         


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
        435                 440                 445             


Tyr Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
    450                 455                 460                 


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
465                 470                 475                 480 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
                485                 490                 495     


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
            500                 505                 510         


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
        515                 520                 525             


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Tyr Ser Ser Val Asn Lys 
    530                 535                 540                 


Pro Gly Gln Leu 
545             


<210>  125
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-001765

<400>  125

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Arg Thr Ser Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly 
    130                 135                 140                 


Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr His Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Glu Tyr Asn Glu Lys 
            180                 185                 190         


Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala 
        195                 200                 205             


Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Glu Glu Ile Thr Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Ser Val Thr Val Ser Ser 
                245         


<210>  126
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2938 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] ICD)

<400>  126
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgag cctcggatct gctggattcc     1020

caggacagca cagggaaacc aaaatgtcat cagagtcggg agctgcccag aatccctccc     1080

gagagcgcag tggataccat gctcacggcg agaagtgtgg acggggacca ggggctgggg     1140

atggaagggc cctatgaagt gctcaaggac agctcctccc aagaaaacat ggtggaggac     1200

tgcttgtatg aaactgtgaa agagatcaag gaggtggctg cagctgcaca cctggagaaa     1260

ggccacagtg gcaaggcaaa atctacttct gcctcgaaag agctcccagg gccccagact     1320

gaaggcaaag ctgagtttgc tgaatatgcc tcggtggaca gaaacaaaaa atgtcgtcaa     1380

agtgttaatg tagagagtat ccttggaaat tcatgtgatc cagaagagga ggccccacca     1440

cctgtccctg ttaagcttct ggacgagaat gaaaaccttc aggagaagga agggggagag     1500

gcggaagaga gtgccacaga cacgaccagt gaaactaaca agagatttag ctcattgtca     1560

tacaagtctc gggaagaaga ccccactctc acagaagaag agatctcagc tatgtactca     1620

tcagtaaata aacctggaca gttatag                                         1647


<210>  127
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3123 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[217-326] ICD)

<400>  127

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Gln Thr Glu 
                325                 330                 335     


Gly Lys Ala Glu Phe Ala Glu Tyr Ala Ser Val Asp Arg Asn Lys Lys 
            340                 345                 350         


Cys Arg Gln Ser Val Asn Val Glu Ser Ile Leu Gly Asn Ser Cys Asp 
        355                 360                 365             


Pro Glu Glu Glu Ala Pro Pro Pro Val Pro Val Lys Leu Leu Asp Glu 
    370                 375                 380                 


Asn Glu Asn Leu Gln Glu Lys Glu Gly Gly Glu Ala Glu Glu Ser Ala 
385                 390                 395                 400 


Thr Asp Thr Thr Ser Glu Thr Asn Lys Arg Phe Ser Ser Leu Ser Tyr 
                405                 410                 415     


Lys Ser Arg Glu Glu Asp Pro Thr Leu Thr Glu Glu Glu Ile Ser Ala 
            420                 425                 430         


Met Tyr Ser Ser Val Asn Lys Pro Gly Gln Leu 
        435                 440             


<210>  128
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Signal peptide AA

<400>  128

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Arg Gly Ala Arg Cys 
            20          


<210>  129
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Signal peptide NA

<400>  129
atggacatga gggtccccgc tcagctcctg gggctcctgc tactctggct ccgaggtgcc       60

agatgt                                                                  66


<210>  130
<211>  1332
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3123 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[217-326] ICD)

<400>  130
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgac agactgaagg caaagctgag     1020

tttgctgaat atgcctcggt ggacagaaac aaaaaatgtc gtcaaagtgt taatgtagag     1080

agtatccttg gaaattcatg tgatccagaa gaggaggccc caccacctgt ccctgttaag     1140

cttctggacg agaatgaaaa ccttcaggag aaggaagggg gagaggcgga agagagtgcc     1200

acagacacga ccagtgaaac taacaagaga tttagctcat tgtcatacaa gtctcgggaa     1260

gaagacccca ctctcacaga agaagagatc tcagctatgt actcatcagt aaataaacct     1320

ggacagttat ag                                                         1332


<210>  131
<211>  412
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3125 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-190] ICD)

<400>  131

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp 
                325                 330                 335     


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
            340                 345                 350         


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
        355                 360                 365             


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
    370                 375                 380                 


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
385                 390                 395                 400 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val 
                405                 410         


<210>  132
<211>  1239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3125 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-190] ICD)

<400>  132
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgag cctcggatct gctggattcc     1020

caggacagca cagggaaacc aaaatgtcat cagagtcggg agctgcccag aatccctccc     1080

gagagcgcag tggataccat gctcacggcg agaagtgtgg acggggacca ggggctgggg     1140

atggaagggc cctatgaagt gctcaaggac agctcctccc aagaaaacat ggtggaggac     1200

tgcttgtatg aaactgtgaa agagatcaag gaggtgtag                            1239


<210>  133
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3137 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] Y227F, 
       Y317F ICD)

<400>  133

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp 
                325                 330                 335     


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
            340                 345                 350         


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
        355                 360                 365             


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
    370                 375                 380                 


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
385                 390                 395                 400 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
                405                 410                 415     


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
            420                 425                 430         


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
        435                 440                 445             


Phe Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
    450                 455                 460                 


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
465                 470                 475                 480 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
                485                 490                 495     


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
            500                 505                 510         


Asn Lys Arg Phe Ser Ser Leu Ser Tyr Lys Ser Arg Glu Glu Asp Pro 
        515                 520                 525             


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Phe Ser Ser Val Asn Lys 
    530                 535                 540                 


Pro Gly Gln Leu 
545             


<210>  134
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3137 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] Y227F, 
       Y317F ICD)

<400>  134
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgag cctcggatct gctggattcc     1020

caggacagca cagggaaacc aaaatgtcat cagagtcggg agctgcccag aatccctccc     1080

gagagcgcag tggataccat gctcacggcg agaagtgtgg acggggacca ggggctgggg     1140

atggaagggc cctatgaagt gctcaaggac agctcctccc aagaaaacat ggtggaggac     1200

tgcttgtatg aaactgtgaa agagatcaag gaggtggctg cagctgcaca cctggagaaa     1260

ggccacagtg gcaaggcaaa atctacttct gcctcgaaag agctcccagg gccccagact     1320

gaaggcaaag ctgagtttgc tgaatttgcc tcggtggaca gaaacaaaaa atgtcgtcaa     1380

agtgttaatg tagagagtat ccttggaaat tcatgtgatc cagaagagga ggccccacca     1440

cctgtccctg ttaagcttct ggacgagaat gaaaaccttc aggagaagga agggggagag     1500

gcggaagaga gtgccacaga cacgaccagt gaaactaaca agagatttag ctcattgtca     1560

tacaagtctc gggaagaaga ccccactctc acagaagaag agatctcagc tatgttctca     1620

tcagtaaata aacctggaca gttatag                                         1647


<210>  135
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3139 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] Y227F, 
       Y299F, Y317F ICD)

<400>  135

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser Tyr Gly Ser Gln Ser Ser Lys Pro Tyr Leu Leu Thr His Pro Ser 
                245                 250                 255     


Asp Pro Leu Glu Leu Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser 
            260                 265                 270         


Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu 
        275                 280                 285             


Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly 
    290                 295                 300                 


Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu Leu Leu Leu Leu 
305                 310                 315                 320 


Leu Leu Leu Phe Leu Ile Asp Arg Glu Lys Lys Pro Arg Ala Ser Asp 
                325                 330                 335     


Leu Leu Asp Ser Gln Asp Ser Thr Gly Lys Pro Lys Cys His Gln Ser 
            340                 345                 350         


Arg Glu Leu Pro Arg Ile Pro Pro Glu Ser Ala Val Asp Thr Met Leu 
        355                 360                 365             


Thr Ala Arg Ser Val Asp Gly Asp Gln Gly Leu Gly Met Glu Gly Pro 
    370                 375                 380                 


Tyr Glu Val Leu Lys Asp Ser Ser Ser Gln Glu Asn Met Val Glu Asp 
385                 390                 395                 400 


Cys Leu Tyr Glu Thr Val Lys Glu Ile Lys Glu Val Ala Ala Ala Ala 
                405                 410                 415     


His Leu Glu Lys Gly His Ser Gly Lys Ala Lys Ser Thr Ser Ala Ser 
            420                 425                 430         


Lys Glu Leu Pro Gly Pro Gln Thr Glu Gly Lys Ala Glu Phe Ala Glu 
        435                 440                 445             


Phe Ala Ser Val Asp Arg Asn Lys Lys Cys Arg Gln Ser Val Asn Val 
    450                 455                 460                 


Glu Ser Ile Leu Gly Asn Ser Cys Asp Pro Glu Glu Glu Ala Pro Pro 
465                 470                 475                 480 


Pro Val Pro Val Lys Leu Leu Asp Glu Asn Glu Asn Leu Gln Glu Lys 
                485                 490                 495     


Glu Gly Gly Glu Ala Glu Glu Ser Ala Thr Asp Thr Thr Ser Glu Thr 
            500                 505                 510         


Asn Lys Arg Phe Ser Ser Leu Ser Phe Lys Ser Arg Glu Glu Asp Pro 
        515                 520                 525             


Thr Leu Thr Glu Glu Glu Ile Ser Ala Met Phe Ser Ser Val Asn Lys 
    530                 535                 540                 


Pro Gly Gln Leu 
545             


<210>  136
<211>  1647
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3139 (NY-ESO-1 ScFv, LILRB1 hinge + TM, PAG1[112-326] Y227F, 
       Y299F, Y317F ICD)

<400>  136
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tcatacggct cacagagctc caaaccctac ctgctgactc accccagtga ccccctggag      780

ctcgtggtct caggaccgtc tgggggcccc agctccccga caacaggccc cacctccaca      840

tctggccctg aggaccagcc cctcaccccc accgggtcgg atccccagag tggtctggga      900

aggcacctgg gggttgtgat cggcatcttg gtggccgtca tcctactgct cctcctcctc      960

ctcctcctct tcctcatcga cagggaaaag aagccgcgag cctcggatct gctggattcc     1020

caggacagca cagggaaacc aaaatgtcat cagagtcggg agctgcccag aatccctccc     1080

gagagcgcag tggataccat gctcacggcg agaagtgtgg acggggacca ggggctgggg     1140

atggaagggc cctatgaagt gctcaaggac agctcctccc aagaaaacat ggtggaggac     1200

tgcttgtatg aaactgtgaa agagatcaag gaggtggctg cagctgcaca cctggagaaa     1260

ggccacagtg gcaaggcaaa atctacttct gcctcgaaag agctcccagg gccccagact     1320

gaaggcaaag ctgagtttgc tgaatttgcc tcggtggaca gaaacaaaaa atgtcgtcaa     1380

agtgttaatg tagagagtat ccttggaaat tcatgtgatc cagaagagga ggccccacca     1440

cctgtccctg ttaagcttct ggacgagaat gaaaaccttc aggagaagga agggggagag     1500

gcggaagaga gtgccacaga cacgaccagt gaaactaaca agagatttag ctcattgtca     1560

ttcaagtctc gggaagaaga ccccactctc acagaagaag agatctcagc tatgttctca     1620

tcagtaaata aacctggaca gttatag                                         1647


<210>  137
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002357 MSLN_(M5)

<400>  137

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Trp Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Asp Ile Val Met Thr Gln Ser Ser Ser Leu Ser Ala 
    130                 135                 140                 


Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
145                 150                 155                 160 


Arg Tyr Tyr Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys 
                165                 170                 175     


Leu Leu Ile Tyr Thr Ala Ser Ile Leu Gln Asn Gly Val Pro Ser Arg 
            180                 185                 190         


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
        195                 200                 205             


Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Thr Tyr Thr 
    210                 215                 220                 


Thr Pro Asp Phe Gly Pro Gly Thr Lys Val Glu Ile Lys 
225                 230                 235         


<210>  138
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002358 MSLN_(M14)

<400>  138

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Ala Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Thr Phe Arg Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Arg Ala Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Ala Ser Cys Gly Gly Asp Cys Tyr Tyr Leu Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Pro Thr Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Glu Asn Val Asn Ile Trp Leu Ala Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ser Ser Ser 
            180                 185                 190         


Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala 
        195                 200                 205             


Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Tyr Gln Ser Tyr Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  139
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002359 MSLN_(S5H)

<400>  139

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Lys Ala Pro Lys Arg Leu Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  140
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002360 MSLN_(S5M)

<400>  140

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Thr Met Asn Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Ile Thr Pro Tyr Asn Gly Ala Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Asp Leu Leu Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Gly Tyr Asp Gly Arg Gly Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Glu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Ser 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Ser Gly 
                165                 170                 175     


Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly Asn Ser Tyr Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Val Glu Ala Glu Asp Asp Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  141
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002361 CEACAM5_(MFE23M)

<400>  141

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Thr 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Ile Met Ser Ala Ser Pro Gly Glu Lys Val Thr Ile Thr Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Phe Gln Gln Lys Pro 
                165                 170                 175     


Gly Thr Ser Pro Lys Leu Trp Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Arg Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  142
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002362 CEACAM5_(MFE23H)

<400>  142

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Ser Tyr Met His Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Leu Ala Pro Arg Leu Leu Ile Tyr Ser Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  143
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002363 CEACAM5_(E8)

<400>  143

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asp 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser Asn Glu Phe Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Ser Ser Glu Leu Thr Gln Asp Pro Ala Val 
    130                 135                 140                 


Ser Val Ala Leu Gly Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser 
145                 150                 155                 160 


Leu Arg Ser Ser Tyr Ala Ser Trp Tyr Arg Gln Arg Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Ser Ser Gly Asn Thr Ala Ser Leu Thr Ile 
        195                 200                 205             


Thr Gly Ala Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Trp Asn Ser Ser 
    210                 215                 220                 


Tyr Ala Trp Leu Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly 
            


<210>  144
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002364 CEACAM5_(SM3E)

<400>  144

Gln Val Gln Leu Glu Gln Ser Gly Ala Gly Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Ser 
            20                  25                  30          


Tyr Met His Trp Leu Arg Gln Gly Pro Gly Gln Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Asp Pro Glu Asn Gly Asp Thr Glu Tyr Ala Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Phe Thr Thr Asp Thr Ser Ala Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gly Leu Ser Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Asn Glu Gly Thr Pro Thr Gly Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Asn Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Met Ser Val Ser Val Gly Asp Arg Val Asn Ile Ala Cys 
145                 150                 155                 160 


Ser Ala Ser Ser Ser Val Pro Tyr Met His Trp Leu Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ser Pro Lys Leu Leu Ile Tyr Leu Thr Ser Asn Leu Ala Ser 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
        195                 200                 205             


Leu Thr Ile Ser Ser Val Gln Pro Glu Asp Ala Ala Thr Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Arg Ser Ser Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  145
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-478 EGFR (VH-VL ScFv Format)

<400>  145

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ala Ile 
    130                 135                 140                 


Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
145                 150                 155                 160 


Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp 
            180                 185                 190         


Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Glu 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
    210                 215                 220                 


Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  146
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-479 EGFR (VL-VH ScFv Format)

<400>  146

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gln Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr Gly Met His Trp 
145                 150                 155                 160 


Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp 
                165                 170                 175     


Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys Gly Arg Phe 
            180                 185                 190         


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
        195                 200                 205             


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Gly 
    210                 215                 220                 


Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  147
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-480 EGFR (VH-VL ScFv format)

<400>  147

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln Thr Pro Leu 
    130                 135                 140                 


Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser 
145                 150                 155                 160 


Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr 
                165                 170                 175     


Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser 
            180                 185                 190         


Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly 
    210                 215                 220                 


Val Tyr Phe Cys Ser Gln Ser Thr His Val Pro Trp Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Leu Glu Ile Lys 
                245         


<210>  148
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-481 EGFR (VL-VH ScFv Format)

<400>  148

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Glu Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu 
145                 150                 155                 160 


Tyr Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp 
                165                 170                 175     


Met Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu 
            180                 185                 190         


Phe Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe 
    210                 215                 220                 


Cys Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Thr Leu Thr Val Ser Ser 
                245         


<210>  149
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-482 EGFR (VH-VL ScFv Format)

<400>  149

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Val Val Met Thr Gln 
    130                 135                 140                 


Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln Ala Ser Ile Ser 
145                 150                 155                 160 


Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu 
                165                 170                 175     


His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
            180                 185                 190         


Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu 
    210                 215                 220                 


Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser Thr His Val Leu Thr Phe 
225                 230                 235                 240 


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
                245                 


<210>  150
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-483 EGFR (VL-VH ScFv Format)

<400>  150

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly 
            100                 105                 110         


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
    130                 135                 140                 


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
145                 150                 155                 160 


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
                165                 170                 175     


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
            180                 185                 190         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
        195                 200                 205             


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
    210                 215                 220                 


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Ser Val Thr Val Ser Ser 
                245                 


<210>  151
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-486 EGFR (VH-VL ScFv Format)

<400>  151

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Leu Leu Thr Gln Ser Pro 
    130                 135                 140                 


Val Ile Leu Ser Val Ser Pro Gly Glu Arg Val Ser Phe Ser Cys Arg 
145                 150                 155                 160 


Ala Ser Gln Ser Ile Gly Thr Asn Ile His Trp Tyr Gln Gln Arg Thr 
                165                 170                 175     


Asn Gly Ser Pro Arg Leu Leu Ile Lys Tyr Ala Ser Glu Ser Ile Ser 
            180                 185                 190         


Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Leu Ser Ile Asn Ser Val Glu Ser Glu Asp Ile Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Gln Gln Asn Asn Asn Trp Pro Thr Thr Phe Gly Ala Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Leu Lys 
            


<210>  152
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-487 EGFR (VH-VL ScFv Format)

<400>  152

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln 
    130                 135                 140                 


Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr 
145                 150                 155                 160 


Cys Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Thr Ser Asn Leu Ala 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Trp Ser Ser His Ile Phe Thr Phe Gly Gln Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  153
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT-488 EGFR (VH-VL ScFv Format)

<400>  153

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser Pro 
    130                 135                 140                 


Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln 
145                 150                 155                 160 


Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro 
                165                 170                 175     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Asp Ala Ser Asn Leu Glu Thr 
            180                 185                 190         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        195                 200                 205             


Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Gln His Phe Asp His Leu Pro Leu Ala Phe Gly Gly Gly Thr Lys Val 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  154
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002357 MSLN_(M5)

<400>  154
caggtgcagc tggtgcagtc tggggctgag gtggagaagc ctggggcctc agtgaaggtc       60

tcctgcaagg cttctggata caccttcacc gactactata tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atcaacccta acagtggtgg cacaaactat      180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac      240

atggagctga gcaggctgag atctgacgac acggccgtgt attactgtgc gtctggctgg      300

gactttgact actggggcca gggaaccctg gtcaccgtgt cctcaggcgg aggtggaagc      360

ggagggggag gatctggcgg cggaggaagc ggaggcgaca tcgtgatgac ccagtcttcc      420

tccctgtctg catctgtcgg agacagagtc accatcactt gccgggccag tcagagcatt      480

aggtactatt taagttggta tcagcagaaa ccaggaaaag cccctaagct cctgatctat      540

actgcatcca ttttacaaaa tggggtccca tcaaggttca gtggcagtgg atctgggaca      600

gatttcactc tcaccatcag cagcctgcaa cctgaggatt ttgcaactta ttactgcctc      660

cagacttaca ctactccgga ctttggccca gggaccaagg tggaaatcaa a               711


<210>  155
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002358 MSLN_(M14)

<400>  155
caggtgcagc tggtgcagtc tggggctgag gtgagggcac ctggggcctc agtgaagatt       60

tcctgcaagg cttctggatt caccttcaga ggctactata tccactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatgggaatc atcaacccta gtggtggtag cagagcctac      180

gcacagaagt tccagggcag ggtcaccatg accagggaca cttccacgag cacagtctac      240

atggagctga gcagcctgag atctgacgac acggccatgt attactgtgc gagaaccgca      300

agttgtggtg gtgactgcta ctaccttgac tactggggcc agggaaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagtctcc tcccaccctg tctgcatctg taggagacag agtcaccatc      480

acttgccggg ccagtgagaa tgttaatatc tggttggcct ggtatcagca gaaaccaggg      540

aaagccccta agctcctgat ctataagtca tccagtttag caagtggggt cccatcaagg      600

ttcagtggca gtggatctgg ggcagaattc actctcacca tcagcagcct gcagcctgat      660

gattttgcaa cttattactg ccaacagtat caaagttacc ccctcacttt cggcggaggg      720

accaaggtgg aaatcaaa                                                    738


<210>  156
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002359 MSLN_(S5H)

<400>  156
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaggcaggcc      120

cctggacaaa gacttgagtg gatgggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcag ggtcacaatc actagagaca cgtcagccag cacagcctac      240

atggagctct ccagcctgag atctgaagac actgcagtct attactgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtctc cttcaagctt gtctgcatct gtaggagaca gggtcaccat cacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aaccaggcaa ggcccctaag      540

agattgatct atgacacatc caaattagca agtggggtcc caagtcgctt cagtggcagt      600

ggatctggga ccgaattcac tctcaccatc agcagcttgc agcctgagga ttttgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtcaggggac aaagttggaa      720

atcaaa                                                                 726


<210>  157
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002360 MSLN_(S5M)

<400>  157
caggtgcagc tgcagcagtc tgggcctgag ctggagaagc ctggggcctc agtgaagatt       60

tcctgcaagg cttctggata ctcattcacc ggctacacca tgaactgggt gaagcagagc      120

catggaaaaa gccttgagtg gattggactt atcacccctt acaatggtgc ttctagctac      180

aaccagaagt tcaggggcaa ggccacatta actgtagaca agtcatccag cacagcctac      240

atggacctcc tcagcctgac atctgaagac tctgcagtct atttctgtgc aagggggggt      300

tacgacggga ggggttttga ctactggggc cagggaacca cggtcaccgt gtcctcaggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcgagctc      420

acccagtctc ctgcaatcat gtctgcatct ccaggagaga aggtcaccat gacttgcagt      480

gccagctcaa gtgtaagtta catgcactgg tatcagcaga aatcaggcac ctcccctaag      540

agatggatct atgacacatc caaattggca agtggggtcc caggtcgctt cagtggcagt      600

ggatctggga actcttactc tctcaccatc agcagcgtgg aggctgagga tgatgcaact      660

tattactgcc agcagtggag tggttaccct ctcacgttcg gtgctgggac aaagttggaa      720

atcaaa                                                                 726


<210>  158
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002361 CEACAM5_(MFE23M)

<400>  158
caggtccagc tgcagcagtc tggggcagag cttgtgaggt cagggacctc agtcaagttg       60

tcctgcacag cttctggctt caacattaaa gactcctata tgcactggtt gaggcagggg      120

cctgaacagg gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactttt actacagaca catcctccaa cacagcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccacagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagaacgtt      420

ctcacccagt ctccagcaat catgtctgca tctccagggg agaaggtcac cataacctgc      480

agtgccagct caagtgtaag ttacatgcac tggttccagc agaagccagg cacttctccc      540

aaactctgga tttatagcac atccaacctg gcttctggag tccctgctcg cttcagtggc      600

agtggatctg ggacctctta ctctctcaca atcagccgaa tggaggctga agatgctgcc      660

acttattact gccagcaaag gagtagttac ccgctcacgt tcggtgctgg gaccaagctg      720

gagctgaaa                                                              729


<210>  159
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002362 CEACAM5_(MFE23H)

<400>  159
caggtccagc tggtgcagtc tggggcagag gtgaagaaac caggggcctc agtcaaggtg       60

tcctgcaaag cttctggctt caacattaaa gactcctata tgcactgggt gaggcaggcg      120

cctggacagg gcctggagtg gatgggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcag ggtcactatg actacagaca catccacctc cacagcctac      240

atggagctca ggagcctgag atctgacgac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccacagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagatcgtt      420

ctcacccagt ctccagcaac cttgtctctg tctccagggg agagggccac cctaagctgc      480

agtgccagct caagtgtaag ttacatgcac tggtaccagc agaagccagg ccttgctccc      540

agactcctga tttatagcac atccaacctg gcttctggaa tccctgatcg cttcagtggc      600

agtggatctg ggaccgattt cactctcaca atcagccgac tggagcctga agatttcgcc      660

gtttattact gccagcaaag gagtagttac ccgctcacgt tcggtcaggg gaccaagctg      720

gagatcaaa                                                              729


<210>  160
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002363 CEACAM5_(E8)

<400>  160
gaggtgcagc tggcggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agcgatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc aaagtctaat      300

gagtttcttt ttgactactg gggccaaggt accctggtca ccgtgtcgag tggcggaggt      360

ggaagcggag ggggaggatc tggcggcgga ggaagcggag gctcttctga gctgactcag      420

gaccctgctg tgtctgtggc cttgggacag acagtcagga tcacatgcca aggagacagc      480

ctcagaagct cttatgcaag ctggtaccgg cagaggccag gacaggcccc tgtacttgtc      540

atctatggta aaaacaaccg gccctcaggg atcccagacc gattctctgg ctccagctca      600

ggaaacacag cttccttgac catcactggg gctcaggcgg aagatgaggc tgactattac      660

tggaactcca gctacgcttg gctgccctac gtggtattcg gcggagggac caagctgacc      720

gtcctaggt                                                              729


<210>  161
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002364 CEACAM5_(SM3E)

<400>  161
caggtccagc tggagcagtc tggggcaggg gttgtgaagc caggggcctc agtcaagttg       60

tcctgcaaag cttctggctt caacattaaa gactcctata tgcactggtt gaggcagggg      120

cctggacagc gcctggagtg gattggatgg attgatcctg agaatggtga tactgaatat      180

gccccgaagt tccagggcaa ggccactttt actacagaca catccgccaa cacagcctac      240

ctggggctca gcagcctgag acctgaggac actgccgtct attactgtaa tgaagggaca      300

ccgacagggc catactattt tgactactgg ggtcaaggaa ccctagtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagaacgtt      420

ctcacccagt ctccaagctc tatgtctgta tctgtcgggg acagggtcaa catcgcctgc      480

agtgccagct caagtgtacc ttacatgcac tggctccagc agaagccagg caaatctccc      540

aaactcctga tttatctcac atccaacctg gcttctggag tccctagccg cttcagtggc      600

agtggatctg ggaccgatta ctctctcaca atcagctcag tgcagcctga agatgctgcc      660

acttattact gccagcaaag gagtagttac ccgctcacgt tcggtggtgg gaccaagctg      720

gagatcaaa                                                              729


<210>  162
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-478 EGFR (VH-VL ScFv Format)

<400>  162
caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc       60

tcctgtgcag cgtctggatt caccttcagt acctatggca tgcactgggt ccgccaggct      120

ccaggcaagg ggctggagtg ggtggcagtt atatgggatg atggaagtta taaatactat      180

ggagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagagatggt      300

attactatgg ttcggggagt tatgaaggac tactttgact actggggcca gggaaccctg      360

gtcaccgtct cctcaggcgg aggtggaagc ggagggggag gatctggcgg cggaggaagc      420

ggaggcgcca tccagttgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga      480

gtcaccatca cttgccgggc aagtcaggac attagcagtg ctttagtctg gtatcagcag      540

aaaccaggga aagctcctaa gctcctgatc tatgatgcct ccagtttgga aagtggggtc      600

ccatcaaggt tcagcggcag tgaatctggg acagatttca ctctcaccat cagcagcctg      660

cagcctgaag attttgcaac ttattactgt caacagttta atagttaccc gctcactttc      720

ggcggaggga ccaaggtgga gatcaaa                                          747


<210>  163
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-479 EGFR (VL-VH ScFv Format)

<400>  163
gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca ggacattagc agtgctttag tctggtatca gcagaaacca      120

gggaaagctc ctaagctcct gatctatgat gcctccagtt tggaaagtgg ggtcccatca      180

aggttcagcg gcagtgaatc tgggacagat ttcactctca ccatcagcag cctgcagcct      240

gaagattttg caacttatta ctgtcaacag tttaatagtt acccgctcac tttcggcgga      300

gggaccaagg tggagatcaa aggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gccaggtgca gctggtggag tctgggggag gcgtggtcca gcctgggagg      420

tccctgagac tctcctgtgc agcgtctgga ttcaccttca gtacctatgg catgcactgg      480

gtccgccagg ctccaggcaa ggggctggag tgggtggcag ttatatggga tgatggaagt      540

tataaatact atggagactc cgtgaagggc cgattcacca tctccagaga caattccaag      600

aacacgctgt atctgcaaat gaacagcctg agagccgagg acacggctgt gtattactgt      660

gcgagagatg gtattactat ggttcgggga gttatgaagg actactttga ctactggggc      720

cagggaaccc tggtcaccgt ctcctca                                          747


<210>  164
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-480 EGFR (VH-VL ScFv format)

<400>  164
cagatccagt tggtgcagtc tggacctgag ctgaagaagc ctggagagac agtcaagatc       60

tcctgcaagg cctctgggta taccttcaca gaatatccaa tacactgggt gaagcaggct      120

ccaggaaagg gtttcaagtg gatgggcatg atatacaccg acattggaaa gccaacatat      180

gctgaagagt tcaagggacg gtttgccttc tctttggaga cctctgccag cactgcctat      240

ttgcagatca acaacctcaa gaatgaggac acggctacat atttctgtgt aagagatcga      300

tatgattccc tctttgacta ctggggccaa ggcaccactc tcacagtctc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tgtgatgacc      420

caaactccac tctccctgcc tgtcagtctt ggagatcaag cctccatctc ttgcagatct      480

agtcagagcc ttgtacacag taatggaaac acctatttac attggtacct gcagaagcca      540

ggccagtctc caaagctcct gatctacaaa gtttccaacc gattttctgg ggtcccagac      600

aggttcagtg gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct      660

gaggatctgg gagtttattt ctgctctcaa agtacacatg ttccgtggac gttcggtgga      720

ggcaccaagc tggaaatcaa a                                                741


<210>  165
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-481 EGFR (VL-VH ScFv Format)

<400>  165
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgta cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttccg      300

tggacgttcg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag atccagttgg tgcagtctgg acctgagctg      420

aagaagcctg gagagacagt caagatctcc tgcaaggcct ctgggtatac cttcacagaa      480

tatccaatac actgggtgaa gcaggctcca ggaaagggtt tcaagtggat gggcatgata      540

tacaccgaca ttggaaagcc aacatatgct gaagagttca agggacggtt tgccttctct      600

ttggagacct ctgccagcac tgcctatttg cagatcaaca acctcaagaa tgaggacacg      660

gctacatatt tctgtgtaag agatcgatat gattccctct ttgactactg gggccaaggc      720

accactctca cagtctcctc a                                                741


<210>  166
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-482 EGFR (VH-VL ScFv Format)

<400>  166
gaaatgcagc tggtggagtc tgggggaggc ttcgtgaagc ctggagggtc cctgaaactc       60

tcatgtgcag cctctggatt cgctttcagt cactatgaca tgtcttgggt tcgccagact      120

ccgaagcaga ggctggagtg ggtcgcatac attgctagtg gtggtgatat cacctactat      180

gcagacactg tgaagggccg attcaccatc tccagagaca atgcccagaa caccctgtac      240

ctgcaaatga gcagtctgaa gtctgaggac acagccatgt tttactgttc acgatcctcc      300

tatggtaaca acggagatgc cctggacttc tggggtcaag gtacctcagt caccgtctcc      360

tcaggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgatgtt      420

gtgatgaccc aaactccact ctccctgcct gtcagtcttg gagatcaagc ctccatctct      480

tgcagatcta gtcagagcct tgttcacagt aatggaaaca cctatttaca ttggtacctg      540

cagaagccag gccagtctcc aaagctcctg atctacaaag tttccaaccg attttctggg      600

gtcccagaca ggttcagtgg cagtggatca gggacagatt tcacactcaa gatcagcaga      660

gtggaggctg aggatctggg agtttatttc tgctctcaaa gtacacatgt tctcacgttc      720

ggctcgggga caaagttgga aataaaa                                          747


<210>  167
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-483 EGFR (VL-VH ScFv Format)

<400>  167
gatgttgtga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagccttgtt cacagtaatg gaaacaccta tttacattgg      120

tacctgcaga agccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agcagagtgg aggctgagga tctgggagtt tatttctgct ctcaaagtac acatgttctc      300

acgttcggct cggggacaaa gttggaaata aaaggcggag gtggaagcgg agggggagga      360

tctggcggcg gaggaagcgg aggcgaaatg cagctggtgg agtctggggg aggcttcgtg      420

aagcctggag ggtccctgaa actctcatgt gcagcctctg gattcgcttt cagtcactat      480

gacatgtctt gggttcgcca gactccgaag cagaggctgg agtgggtcgc atacattgct      540

agtggtggtg atatcaccta ctatgcagac actgtgaagg gccgattcac catctccaga      600

gacaatgccc agaacaccct gtacctgcaa atgagcagtc tgaagtctga ggacacagcc      660

atgttttact gttcacgatc ctcctatggt aacaacggag atgccctgga cttctggggt      720

caaggtacct cagtcaccgt ctcctca                                          747


<210>  168
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-486 EGFR (VH-VL ScFv Format)

<400>  168
caggtgcagc tgaagcagtc cggccccggc ctggtgcagc cctcccagtc cctgtccatc       60

acctgcaccg tgtccggctt ctccctgacc aactacggcg tgcactgggt gcggcagtcc      120

cccggcaagg gcctggagtg gctgggcgtg atctggtccg gcggcaacac cgactacaac      180

acccccttca cctcccggct gtccatcaac aaggacaact ccaagtccca ggtgttcttc      240

aagatgaact ccctgcagtc caacgacacc gccatctact actgcgcccg ggccctgacc      300

tactacgact acgagttcgc ctactggggc cagggcaccc tggtgaccgt gtccgccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catcctgctg      420

acccagtccc ccgtgatcct gtccgtgtcc cccggcgagc gggtgtcctt ctcctgccgg      480

gcctcccagt ccatcggcac caacatccac tggtaccagc agcggaccaa cggctccccc      540

cggctgctga tcaagtacgc ctccgagtcc atctccggca tcccctcccg gttctccggc      600

tccggctccg gcaccgactt caccctgtcc atcaactccg tggagtccga ggacatcgcc      660

gactactact gccagcagaa caacaactgg cccaccacct tcggcgccgg caccaagctg      720

gagctgaag                                                              729


<210>  169
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-487 EGFR (VH-VL ScFv Format)

<400>  169
caggtgcagc tggtgcagtc cggcgccgag gtgaagaagc ccggcgcctc cgtgaaggtg       60

tcctgcaagg cctccggcta caccttcacc tcccactgga tgcactgggt gcggcaggcc      120

cccggccagg gcctggagtg gatcggcgag ttcaacccct ccaacggccg gaccaactac      180

aacgagaagt tcaagtccaa ggccaccatg accgtggaca cctccaccaa caccgcctac      240

atggagctgt cctccctgcg gtccgaggac accgccgtgt actactgcgc ctcccgggac      300

tacgactacg acggccggta cttcgactac tggggccagg gcaccctggt gaccgtgtcc      360

tccggcggag gtggaagcgg agggggagga tctggcggcg gaggaagcgg aggcgacatc      420

cagatgaccc agtccccctc ctccctgtcc gcctccgtgg gcgaccgggt gaccatcacc      480

tgctccgcct cctcctccgt gacctacatg tactggtacc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacga cacctccaac ctggcctccg gcgtgccctc ccggttctcc      600

ggctccggct ccggcaccga ctacaccttc accatctcct ccctgcagcc cgaggacatc      660

gccacctact actgccagca gtggtcctcc cacatcttca ccttcggcca gggcaccaag      720

gtggagatca ag                                                          732


<210>  170
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CT-488 EGFR (VH-VL ScFv Format)

<400>  170
caggtgcagc tgcaggagtc cggccccggc ctggtgaagc cctccgagac cctgtccctg       60

acctgcaccg tgtccggcgg ctccgtgtcc tccggcgact actactggac ctggatccgg      120

cagtcccccg gcaagggcct ggagtggatc ggccacatct actactccgg caacaccaac      180

tacaacccct ccctgaagtc ccggctgacc atctccatcg acacctccaa gacccagttc      240

tccctgaagc tgtcctccgt gaccgccgcc gacaccgcca tctactactg cgtgcgggac      300

cgggtgaccg gcgccttcga catctggggc cagggcacca tggtgaccgt gtcctccggc      360

ggaggtggaa gcggaggggg aggatctggc ggcggaggaa gcggaggcga catccagatg      420

acccagtccc cctcctccct gtccgcctcc gtgggcgacc gggtgaccat cacctgccag      480

gcctcccagg acatctccaa ctacctgaac tggtaccagc agaagcccgg caaggccccc      540

aagctgctga tctacgacgc ctccaacctg gagaccggcg tgccctcccg gttctccggc      600

tccggctccg gcaccgactt caccttcacc atctcctccc tgcagcccga ggacatcgcc      660

acctacttct gccagcactt cgaccacctg cccctggcct tcggcggcgg caccaaggtg      720

gagatcaag                                                              729


<210>  171
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT478, CT479 EGFR VH

<400>  171

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  172
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT478, CT479 EGFR VL

<400>  172

Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ser Ala 
            20                  25                  30          


Leu Val Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Glu Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  173
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT480, CT481 EGFR VH

<400>  173

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Pro Ile His Trp Val Lys Gln Ala Pro Gly Lys Gly Phe Lys Trp Met 
        35                  40                  45              


Gly Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe 
    50                  55                  60                  


Lys Gly Arg Phe Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Asp Arg Tyr Asp Ser Leu Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  174
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT480, CT481 EGFR VL

<400>  174

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  175
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT482, CT483 VH

<400>  175

Glu Met Gln Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser His Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Lys Gln Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Gln Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys 
                85                  90                  95      


Ser Arg Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  176
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT482, CT483 VL

<400>  176

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  177
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT486 VH

<400>  177

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  178
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  178

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
        35                  40                  


<210>  179
<211>  64
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  179

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Gly Gly Ser Gly Asn Ser Ser Gly Ser Gly Gly Ser Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


<210>  180
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  180

Ala Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Pro Val Pro Ser 
1               5                   10                  15      


Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr Pro Ser Pro Ser 
            20                  25                  30          


Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser Thr Pro Pro Thr 
        35                  40                  45              


Pro Ser Pro Ser Pro Val Pro Ser Thr Pro Pro Thr Asn Ser Ser Ser 
    50                  55                  60                  


Thr Pro Pro Thr Pro Ser Pro Ser Ala Ser Val 
65                  70                  75  


<210>  181
<211>  85
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  181

Val Val Ser Gly Pro Ser Gly Gly Pro Ser Ser Pro Thr Thr Gly Pro 
1               5                   10                  15      


Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr Pro Thr Gly Ser 
            20                  25                  30          


Asp Pro Gln Ser Gly Leu Gly Arg His Val Val Ser Gly Pro Ser Gly 
        35                  40                  45              


Gly Pro Ser Ser Pro Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu 
    50                  55                  60                  


Asp Gln Pro Leu Thr Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly 
65                  70                  75                  80  


Arg His Leu Gly Val 
                85  


<210>  182
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LILRB1 hinge domain

<400>  182

Thr Thr Gly Pro Thr Ser Thr Ser Gly Pro Glu Asp Gln Pro Leu Thr 
1               5                   10                  15      


Pro Thr Gly Ser Asp Pro Gln Ser Gly Leu Gly Arg His Leu Gly Val 
            20                  25                  30          


<210>  183

<400>  183
000

<210>  184

<400>  184
000

<210>  185

<400>  185
000

<210>  186

<400>  186
000

<210>  187

<400>  187
000

<210>  188
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT486 VL

<400>  188

Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  189
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT487 VH

<400>  189

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser His 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Ala Thr Met Thr Val Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  190
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT487 VL

<400>  190

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Asn Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu 
65                  70                  75                  80  


Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser His Ile Phe Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  191
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT488 VH

<400>  191

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  192
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CT488 VL

<400>  192

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  193
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  193

Thr Tyr Gly Met His 
1               5   


<210>  194
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  194

Glu Tyr Pro Ile His 
1               5   


<210>  195
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  195

His Tyr Asp Met Ser 
1               5   


<210>  196
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  196

Asn Tyr Gly Val His 
1               5   


<210>  197
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  197

Ser His Trp Met His 
1               5   


<210>  198
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H1

<400>  198

Ser Gly Asp Tyr Tyr Trp Thr 
1               5           


<210>  199
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  199

Val Ile Trp Asp Asp Gly Ser Tyr Lys Tyr Tyr Gly Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  200
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  200

Met Ile Tyr Thr Asp Ile Gly Lys Pro Thr Tyr Ala Glu Glu Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  201
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  201

Tyr Ile Ala Ser Gly Gly Asp Ile Thr Tyr Tyr Ala Asp Thr Val Lys 
1               5                   10                  15      


Gly 
    


<210>  202
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  202

Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr Ser 
1               5                   10                  15      


<210>  203
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  203

Glu Phe Asn Pro Ser Asn Gly Arg Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  204
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H2

<400>  204

His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  205
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  205

Asp Gly Ile Thr Met Val Arg Gly Val Met Lys Asp Tyr Phe Asp Tyr 
1               5                   10                  15      


<210>  206
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  206

Asp Arg Tyr Asp Ser Leu Phe Asp Tyr 
1               5                   


<210>  207
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  207

Ser Ser Tyr Gly Asn Asn Gly Asp Ala Leu Asp Phe 
1               5                   10          


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  208

Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10      


<210>  209
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  209

Arg Asp Tyr Asp Tyr Asp Gly Arg Tyr Phe Asp Tyr 
1               5                   10          


<210>  210
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR H3

<400>  210

Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   


<210>  211
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L1

<400>  211

Arg Ala Ser Gln Asp Ile Ser Ser Ala Leu Val 
1               5                   10      


<210>  212
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L1

<400>  212

Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  213
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L1

<400>  213

Arg Ala Ser Gln Ser Ile Gly Thr Asn Ile His 
1               5                   10      


<210>  214
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L1

<400>  214

Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr 
1               5                   10  


<210>  215
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L1

<400>  215

Gln Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  216
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L2

<400>  216

Asp Ala Ser Ser Leu Glu Ser 
1               5           


<210>  217
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L2

<400>  217

Lys Val Ser Asn Arg Phe Ser 
1               5           


<210>  218
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L2

<400>  218

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  219
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L2

<400>  219

Asp Thr Ser Asn Leu Ala Ser 
1               5           


<210>  220
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L2

<400>  220

Asp Ala Ser Asn Leu Glu Thr 
1               5           


<210>  221
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  221

Gln Gln Phe Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  222
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  222

Ser Gln Ser Thr His Val Pro Trp Thr 
1               5                   


<210>  223
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  223

Ser Gln Ser Thr His Val Leu Thr 
1               5               


<210>  224
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  224

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  225
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  225

Gln Gln Trp Ser Ser His Ile Phe Thr 
1               5                   


<210>  226
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EGFR CDR L3

<400>  226

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  227
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002170 W632 scFv (mouse)

<400>  227

Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Leu Ser Ile Arg Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Ala Asp Asp Thr Ala Ile Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Ile Cys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg 
            180                 185                 190         


Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp 
        195                 200                 205             


Phe Thr Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr 
    210                 215                 220                 


Phe Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Arg 
                245     


<210>  228
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002171 W632.1 scFv (humanized)

<400>  228

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Ser 
    130                 135                 140                 


Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  229
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002172 W632.2 scFv (humanized)

<400>  229

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  230
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002173 W632.3 scFv (humanized)

<400>  230

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Val Met Thr Gln Thr 
    130                 135                 140                 


Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys 
145                 150                 155                 160 


Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala Trp Tyr Leu Gln Lys 
                165                 170                 175     


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  231
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002174 W632.5 scFv (humanized)

<400>  231

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Ile Val Leu Thr Gln Ser 
    130                 135                 140                 


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Val Ser Asn Asp Leu Ala Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gln Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  232
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-002175 W632.6 scFv (humanized)

<400>  232

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Trp Ser Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Thr Phe Thr Thr Ser Thr Ser Ala Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Gln Ala Ser Gln Ser Val Ser Asn Asp Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
            180                 185                 190         


Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Phe Thr Ile Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asp Tyr Ser Ser Pro Pro Trp Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  233
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002170 W632 scFv (mouse)

<400>  233
caggtgcagc tgaagcagtc aggacctggc ctagtgcagc cctcacagag cctgtccctg       60

acctgcacag tctctggttt ctcattaact agttatggcg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagact gagcatcagg aaggacaact ccaagagcca agtcttcttt      240

aaaatgaaca gtctgcaagc tgatgacaca gccatatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cagcatcgtg      420

atgacccaga ctccaaaatt cctgcttgtg tctgcgggag acagagtcac catcacttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggcaatct      540

cctatctgtc tcctgatcta ctatgcatct aatcggtata caggggtccc tgataggttc      600

accggaagtg gatatgggac agatttcact ttcaccatca gcaccgtgca ggctgaagat      660

cttgcagtat atttctgtca acaggattat agtagtcctc cgtggacttt cggcggaggg      720

accaagttgg agatcaga                                                    738


<210>  234
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002171 W632.1 scFv (humanized)

<400>  234
caggtgcagc tgcaggagtc cggacctggc ctagtgaagc cctcacagac cctgtccctg       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactggat tagacagcct      120

ccaggaaagg gtctggagtg gattggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagagt gaccatcagc gtggacacct ccaagaacca attctccctt      240

aaactgagca gtgtgacagc tgccgacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatcgtg      420

atgacccaga gtccagattc cctggctgtg tctctgggag agagagccac catcaattgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggcaacct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactctc accatcagca gcctgcaggc tgaagatgtt      660

gcagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  235
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002172 W632.2 scFv (humanized)

<400>  235
gaggtgcagc tgctggagtc cggaggtggc ctagtgcagc ccggagggag cctgcgcctg       60

agctgcgcag cctctggttt ctcattaact agctatggtg tacactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttagcgtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gtccaagctc cctgtctgcg tctgtgggag acagagtcac catcacttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc agcagaaacc agggaaagct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctag taggttcagc      600

ggaagtggat ctgggacaga tttcactttc accatcagca gcctgcagcc tgaagatatt      660

gcaacatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  236
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002173 W632.3 scFv (humanized)

<400>  236
caggtgcagc tgcaggagtc cggacctggc ctagtgaagc cctcagaaac cctgtccctg       60

acctgcacag tctctggttt ctcattaact agctatggtg tacactggat tagacagcct      120

ccaggaaagg gtctggagtg gattggagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagagt gaccatcagc agggacacct ccaagaacca attctccctt      240

aaactgagca gtgtgacagc tgccgacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatcgtg      420

atgacccaga ctccactttc cctgtctgtg actccgggac agccagccag catcagttgc      480

aaggcgagtc agtctgtgag caacgacgta gcttggtatc tgcagaaacc agggcaatct      540

cctcaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactttg aagatcagca gggtggaggc tgaagatgtt      660

ggagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  237
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002174 W632.5 scFv (humanized)

<400>  237
caggtgcagc tggtggagtc cggaggtggc gtagtgcagc ccggaaggag cctgcgcctg       60

agctgcgcag tctctggttt ctcattaact agctatggta tgcactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttgcagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccaa aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgagatcgtg      420

ctgacccaga gtccagctac cctgtctctg tctccgggag agagagccac cctcagttgc      480

agggcgagtc agtctgtgag caacgaccta gcttggtatc agcagaaacc agggcaagct      540

cctagactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactctc accatcagca gcctggagcc tgaagatttt      660

gcagtatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg ccaagggacc      720

aaggtggaga tcaaa                                                       735


<210>  238
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002175 W632.6 scFv (humanized)

<400>  238
caggtgcagc tggtggagtc cggaggtggc gtagtgcagc ccggaaggag cctgcgcctg       60

agctgcgcag tctctggttt ctcattaact agctatggta tgcactgggt tagacaggct      120

ccaggaaagg gtctggagtg ggttgcagtg atctggagtg gtggaagcac agactataat      180

gctgctttca tatccagatt taccatcagc cgggacaact ccaagaacac actctacctt      240

caaatgaaca gtttgagagc tgaagacaca gccgtatact actgtgccag aacctttact      300

acgtctacct cggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctcttca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gtccaagctc cctgtctgcg tctgtgggag acagagtcac catcacttgc      480

caggcgagtc agtctgtgag caacgaccta aattggtatc agcagaaacc agggaaagct      540

cctaaactcc tgatctacta tgcatctaat cggtatacag gggtccctga taggttcagc      600

ggaagtggat ctgggacaga tttcactttc accatcagca gcctgcagcc tgaagatatt      660

gcaacatatt actgtcaaca ggattatagt agtcctccgt ggactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  239
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA intracellular domain

<400>  239

Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser Asp Thr Ala Gly Arg 
1               5                   10                  15      


Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser Glu Gln Thr Glu Ala 
            20                  25                  30          


Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser Glu Thr Gly Ile Tyr 
        35                  40                  45              


Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln Glu Gly Ser Glu Val 
    50                  55                  60                  


Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro Gly Ile Val Tyr Ala 
65                  70                  75                  80  


Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser Arg Leu Ala Arg Asn 
                85                  90                  95      


Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile Cys Val Arg Ser 
            100                 105                 110     


<210>  240
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BTLA transmembrane domain and intracellular domain

<400>  240

Leu Leu Pro Leu Gly Gly Leu Pro Leu Leu Ile Thr Thr Cys Phe Cys 
1               5                   10                  15      


Leu Phe Cys Cys Leu Arg Arg His Gln Gly Lys Gln Asn Glu Leu Ser 
            20                  25                  30          


Asp Thr Ala Gly Arg Glu Ile Asn Leu Val Asp Ala His Leu Lys Ser 
        35                  40                  45              


Glu Gln Thr Glu Ala Ser Thr Arg Gln Asn Ser Gln Val Leu Leu Ser 
    50                  55                  60                  


Glu Thr Gly Ile Tyr Asp Asn Asp Pro Asp Leu Cys Phe Arg Met Gln 
65                  70                  75                  80  


Glu Gly Ser Glu Val Tyr Ser Asn Pro Cys Leu Glu Glu Asn Lys Pro 
                85                  90                  95      


Gly Ile Val Tyr Ala Ser Leu Asn His Ser Val Ile Gly Pro Asn Ser 
            100                 105                 110         


Arg Leu Ala Arg Asn Val Lys Glu Ala Pro Thr Glu Tyr Ala Ser Ile 
        115                 120                 125             


Cys Val Arg Ser 
    130         


<210>  241
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-001765 nucleic acid sequence

<400>  241
gatgttttga tgacccaaac tccactctcc ctgcctgtca gtcttggaga tcaagcctcc       60

atctcttgca gatctagtca gagcattgta catagtaatg gaaacaccta tttagaatgg      120

tacctgcaga aaccaggcca gtctccaaag ctcctgatct acaaagtttc caaccgattt      180

tctggggtcc cagacaggtt cagtggcagt ggatcaggga cagatttcac actcaagatc      240

agtagagtgg aggctgagga tctgggagtt tattactgct ttcaaggttc acatgttcct      300

cggacgtccg gtggaggcac caagctggaa atcaaaggcg gaggtggaag cggaggggga      360

ggatctggcg gcggaggaag cggaggccag gtccagctgc agcagtctgg acctgagctg      420

gtgaagcctg gggcttcagt gaggatatcc tgcaaggctt ctggctacac cttcacaagt      480

taccatatac attgggtgaa gcagaggcct ggacagggac ttgagtggat tggatggatt      540

tatcctggaa atgttaatac tgagtacaat gagaagttca agggcaaggc cacactgact      600

gcagacaaat cgtccagcac agcctacatg cacctcagca gcctgacctc tgaggactct      660

gcggtctatt tctgtgccag agaggagatt acctatgcta tggactactg gggtcaagga      720

acctcagtca ccgtgtcctc a                                                741


<210>  242
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002159 PA2.1.8 scFv (humanized)

<400>  242
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat tgtattgacc      420

cagagcccag gcaccctgag cctctctcca ggagagcggg ccaccctcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtcaagccc caagattgct catctacaaa gtctctaaca gatttagtgg tattccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctccag gctcgagcca      660

gaagatttcg ccgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  243
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002160 PA2.1.9 scFv (humanized)

<400>  243
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tgtaatgacc      420

cagaccccac tcagcctgcc cgtcactcca ggagagccgg ccagcatcag ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatct gcagaaacca      540

ggtcaatccc cacaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctccag ggtcgaggca      660

gaagatgtcg gcgtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  244
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002161 PA2.1.10 scFv (humanized)

<400>  244
gaggtgcagc tggtggagtc tgggggtggg ctggtgaagc ctgggggctc actgaggctt       60

tcctgcgcgg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggaaaag ggcttgagtg ggtgggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcag attcaccatt agcagggacg attccaagaa cacactctac      240

ctgcagatga acagcctgaa aactgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccacag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccagcctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccaagc      600

aggttcagcg gttccggaag tggtactgat ttcaccctca cgatctcctc tctccagcca      660

gaagatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtggg      720

ggtactaaag tagaaatcaa a                                                741


<210>  245
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002162 PA2.1.14 scFv (humanized)

<400>  245
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tacattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatgg atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccatt accgcggacg aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt attactgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagcc      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  246
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002163 PA2.1.18 scFv (humanized)

<400>  246
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc agtgaaggtt       60

tcctgcaagg cttctggata caccttcact agctatcata tgcattgggt gcgccaggcc      120

cccggacaag ggcttgagtg gatcggatac atctaccctg gcaatgttaa cacagaatat      180

aatgagaagt tcaagggcaa agccaccctt accgcggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaagac acggctgtgt atttctgtgc gagggaggaa      300

attacctacg ctatggacta ctggggccag ggaaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacgt tcaaatgacc      420

cagagcccat ccaccctgag cgcatctgta ggtgaccggg tcaccatcac ttgtagctcc      480

agtcagagta ttgtacacag taatgggaac acctatatgg aatggtatca gcagaaacca      540

ggtaaagccc caaaattgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgaa ttcaccctca cgatctcctc tctccagcca      660

gatgatttcg ccacttatta ctgtcatcaa ggttcacatg tgccgcgcac attcggtcag      720

ggtactaaag tagaagtcaa a                                                741


<210>  247
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002164 BB7.2 scFv (mouse)

<400>  247
caggtgcagc tgcagcagtc tgggcctgag ctggtgaagc ctggggcctc agtgaagatg       60

tcctgcaagg cttctggata caccttcact agctatcata tccagtgggt gaagcagagg      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggtag tacacagtat      180

aatgagaagt tcaagggcaa aaccaccctt accgcggaca aatcctccag cacagcctac      240

atgttgctga gcagcctgac ctctgaagac tctgctatct atttctgtgc gagggagggg      300

acctactacg ctatggacta ctggggccag ggaacctcag tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgatgt tttgatgacc      420

cagactccac tctccctgcc tgtctctctt ggagaccaag tctccatctc ttgtagatcc      480

agtcagagta ttgtacacag taatgggaac acctatttag aatggtatct gcagaaacca      540

ggtcagtctc caaagttgct catctacaaa gtctctaaca gatttagtgg tgtaccagac      600

aggttcagcg gttccggaag tggtactgat ttcaccctca agatctcgag agtggaggct      660

gaggatctgg gagtttatta ctgttttcaa ggttcacatg tgccgcgcac attcggtgga      720

ggtactaaac tggaaatcaa a                                                741


<210>  248
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002165 BB7.2.1 scFv (humanized)

<400>  248
cagctgcagc tgcaggagtc tgggcccggg ctggtgaagc cttcggaaac gctgagcctc       60

acctgcacgg tttctggata caccttcacc agctatcata tccagtggat ccgacagccc      120

cctggaaaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agccacgatt agcgtggaca catccaagaa ccaattctcc      240

ctgaacctgg acagcgtgag tgctgcggac acggccattt attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggcaaa gggagcacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccaa gctccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccttca cgattagcag cttgcagccc      660

gaagacatcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggccg      720

ggcacgaaag tggatattaa g                                                741


<210>  249
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002166 BB7.2.2 scFv (humanized)

<400>  249
gaggtgcagc tggtgcagtc tggggccgag ctgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt aaaacaggcc      120

cctggacaag ggcttgagtg gatcggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agccacgctt accgtggaca aatccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat ccagatgacc      420

cagagcccat ccaccctgag tgcgtccgtg ggcgaccgcg tgaccatcac ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggaaggccc cgaaactgct catctacaag gtgagcaacc ggttctccgg cgtccccagc      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagcag cttgcagccc      660

gatgacttcg ccacgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggcag      720

ggcacgaaag tggaagttaa g                                                741


<210>  250
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002167 BB7.2.3 scFv (humanized)

<400>  250
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tccagtgggt acgacaggcc      120

cctggacaag ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcag agtcacgatt accgcggaca aatccacgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccacgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg agtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctacaag gtgagcaacc ggttctccgg catccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgctttcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  251
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002168 BB7.2.5 scFv (humanized)

<400>  251
caggtgaccc tgaagcagtc tggggccgag gtgaagaagc ctgggtcctc ggtgaaggtg       60

tcctgcacgg cttctggata caccttcacc agctatcatg tcagctgggt acgacaggcc      120

cctggacaag ggcttgagtg gttgggaagg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt accgcggaca aatccatgga cacatccttc      240

atggagctga ccagcctgac atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacct ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgagat cgtcctgacc      420

cagagcccag ggaccctgag tttgtccccg ggcgagcgcg cgaccctcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg cgtggtacca gcagaagccc      540

gggcaggccc cgcgactgct catctccaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca cgattagccg cttggagccc      660

gaagacttcg ccgtgtacta ctgccaacag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  252
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-002169 BB7.2.6 scFv (humanized)

<400>  252
caggtgcagc tggtgcagtc tggggccgag gtgaagaagc ctggggcctc ggtgaaggtg       60

tcctgcaagg cttctggata caccttcacc agctatcata tgcactgggt acgacaggcc      120

cctggacaaa ggcttgagtg gatgggatgg atctaccctg gcgatggttc aacacagtac      180

aatgagaagt tcaagggcaa agtcacgatt acccgggaca catccgcgag cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtat attactgtgc gagagaggga      300

acttactacg ctatggacta ctggggccaa gggaccctgg tcaccgtgtc ctcaggcgga      360

ggtggaagcg gagggggagg atctggcggc ggaggaagcg gaggcgacat cgtcatgacc      420

cagaccccac tgtccctgcc tgtgaccccg ggcgagcccg cgagcatcag ttgcagatcc      480

tctcagtcca tcgtgcactc caacggcaac acgtacctcg actggtacct gcagaagccc      540

gggcagtccc cgcaactgct catctacaag gtgagcaacc ggttctccgg cgtccccgac      600

cgcttctcag ggtccggctc ggggacggat ttcaccctca agattagccg cgtggaggcc      660

gaagacgtcg gcgtgtacta ctgcatgcag ggaagtcacg tgccgcgtac cttcgggggg      720

ggcacgaaag tggaaattaa g                                                741


<210>  253
<211>  241
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-1761/C-266 (NY-ESO -1 scFv)

<400>  253

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Glu Val Gln Leu 
        115                 120                 125             


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
    130                 135                 140                 


Ser Cys Ala Ala Ser Gly Phe Thr Val Tyr Asp Tyr Met Ser Trp Val 
145                 150                 155                 160 


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Tyr Ser 
                165                 170                 175     


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            180                 185                 190         


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
        195                 200                 205             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Ser Tyr Tyr 
    210                 215                 220                 


Tyr Tyr Tyr Met Asp Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  254
<211>  723
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-1761/C-266 (NY-ESO -1 scFv)

<400>  254
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      120

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      300

ggaacaaagg tggagatcaa gggcggaggt ggaagcggag ggggaggatc tggcggcgga      360

ggaagcggag gcgaagtgca gctggtggaa agcggcggag gcctggtgca gcctggcggc      420

agcctgagac tgtcttgcgc cgccagcggc ttcaccgtgt acgactacat gagctgggtc      480

cgccaggccc ctggcaaggg actggaatgg gtgtccgtga tctacagcgg cggcagcacc      540

tactacgccg acagcgtgaa gggtcgattc accatcagcc gggacaacag caagaacacc      600

ctgtacctgc agatgaacag cctgcgggcc gaggacaccg ccgtgtatta ctgtgcgagg      660

tactcctact actactacta catggacgtc tggggcaaag ggaccacggt caccgtgtcc      720

tca                                                                    723


<210>  255
<211>  1299
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-1797 (full length PAG1)

<400>  255
atggggcccg cggggagcct gctgggcagc ggacagatgc agatcaccct gtggggaagt       60

ctggctgctg tcgccatttt cttcgtcatc accttcctca tcttcctgtg ctctagttgt      120

gacagggaaa agaagccgcg acagcatagt ggggaccatg agaacctgat gaacgtgcct      180

tcagacaagg agatgttcag ccgttcagtt actagcctgg caacagatgc tcctgccagc      240

agtgagcaga atggggcact caccaatggg gacattcttt cagaggacag tactctgacc      300

tgcatgcagc attacgagga agtccagaca tcggcctcgg atctgctgga ttcccaggac      360

agcacaggga aaccaaaatg tcatcagagt cgggagctgc ccagaatccc tcccgagagc      420

gcagtggata ccatgctcac ggcgagaagt gtggacgggg accaggggct ggggatggaa      480

gggccctatg aagtgctcaa ggacagctcc tcccaagaaa acatggtgga ggactgcttg      540

tatgaaactg tgaaagagat caaggaggtg gctgcagctg cacacctgga gaaaggccac      600

agtggcaagg caaaatctac ttctgcctcg aaagagctcc cagggcccca gactgaaggc      660

aaagctgagt ttgctgaata tgcctcggtg gacagaaaca aaaaatgtcg tcaaagtgtt      720

aatgtagaga gtatccttgg aaattcatgt gatccagaag aggaggcccc accacctgtc      780

cctgttaagc ttctggacga gaatgaaaac cttcaggaga aggaaggggg agaggcggaa      840

gagagtgcca cagacacgac cagtgaaact aacaagagat ttagctcatt gtcatacaag      900

tctcgggaag aagaccccac tctcacagaa gaagagatct cagctatgta ctcatcagta      960

aataaacctg gacagttagt gaataaatcg gggcagtcgc ttacagttcc ggagtccacc     1020

tacacctcca ttcaagggga cccacagagg tcaccctcct cctgtaatga tctctatgct     1080

actgttaaag acttcgaaaa aactccaaac agcacacttc caccagcagg gaggcccagc     1140

gaggagccag agcctgatta tgaagcgata cagactctca acagagagga agaaaaggcc     1200

accctgggga ccaatggcca ccacggtctc gtcccaaagg agaacgacta cgagagcata     1260

agtgacttgc agcaaggcag agatattacc aggctctag                            1299


<210>  256
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2300/C-2195  (KRAS G12V pep14)

<400>  256

Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Cys Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Leu Ile Asp Trp Asp Asp Asp Lys Tyr Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Tyr Asp Glu Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Trp Thr Ser Tyr Leu Asn Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu 
            180                 185                 190         


Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
        195                 200                 205             


Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr 
    210                 215                 220                 


Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  257
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2300/C-2195 (KRAS G12V pep14)

<400>  257
caggtcacac tgagagagtc cggccctgcc ctggtgaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc accagcggga tgtgcgtgtc ctggattcga      120

cagccccctg gcaaggccct ggaatggctg gccctgattg actgggacga cgacaagtac      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cgtattactg tgcacggagt      300

tacgacgagc tctactactt tgactactgg ggccagggaa ccctggtcac cgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagctc cctctctgca tctgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatctg gaccagctac ctgaactggt atcagcagaa gcccggcaag      540

gcccccaagc tgctgatcta cgccgccagc tccctgcaga gcggcgtgcc aagcagattc      600

agcggcagcg gctccggcac cgacttcacc ctgaccatca gcagcctgca gcccgaggac      660

ttcgccacct actactgcca gcagagttac agtacccctc tcactttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  258
<211>  246
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2752/C-1511 (MAGE-A3 pep2)

<400>  258

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Asp Thr Phe Ser Met Val Thr Leu Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Trp Pro Leu Thr Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Val Glu Ile Lys 
                245     


<210>  259
<211>  738
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2752/C-1511 (MAGE-A3 pep2)

<400>  259
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ccggcagcag cgtgaaggtg       60

tcctgcaagg ccagcggcgg caccttcagc agctacgcca tcagctgggt ccgccaggct      120

cctggacagg gactggaatg gatgggcggc atcatcccca tcttcggcac cgccaactac      180

gcccagaaat tccagggcag agtgaccatc accgccgacg agagcaccag caccgcctac      240

atggaactga gcagccttcg aagcgaggac accgctgtgt attactgtgc cagggacatg      300

gacaccttct ccatggtgac cctgttcgac tactggggcc agggcaccct ggtcaccgtg      360

tcctcaggcg gaggtggaag cggaggggga ggatctggcg gcggaggaag cggaggcgac      420

atccagatga cccagagccc cagcagcctg agcgccagcg tgggcgacag agtgaccatc      480

acctgtcggg ccagccagtc gatcagcagc tacctgaact ggtatcagca gaagcccggc      540

aaggccccca agctgctgat ctacgccgcc agctccctgc agagcggcgt gccaagcaga      600

ttcagcggca gcggctccgg caccgacttc accctgacca tcagcagcct gcagcccgag      660

gacttcgcca cctactactg ccagcagagt tacagttggc ctctcacttt cggcggaggg      720

accaaggtgg agatcaaa                                                    738


<210>  260
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-2753/C-782 (HPV E7 pep2)

<400>  260

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala 
            20                  25                  30          


Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Arg Ile Lys Ser Lys Thr Asp Gly Gly Thr Thr Asp Tyr Ala Ala 
    50                  55                  60                  


Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Thr Ser Tyr Asp Tyr Leu Leu Asn Pro Tyr Arg Trp Asn 
            100                 105                 110         


Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
145                 150                 155                 160 


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
                165                 170                 175     


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
            180                 185                 190         


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
        195                 200                 205             


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
    210                 215                 220                 


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu 
225                 230                 235                 240 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
                245                 250     


<210>  261
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3390/C-2387 (HPV E6 pep1)

<400>  261

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Ser Arg Ile Asn Ser Asp Gly Ser Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asn Gly Val Val Lys Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Thr Pro Leu Phe Pro Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Val Glu Ile Lys 
                245 


<210>  262
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3391/C-1043 (HPV E6 pep1)

<400>  262

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Asn Ser Gly Ser Ile Gly Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Gly Arg Gly Ser Pro Phe Tyr Gly Gly Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Pro Leu Thr Phe Gly Gly 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  263
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3393/C-563 (MAGE-A3 pep1)

<400>  263

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Ser 
            20                  25                  30          


Asn Trp Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Met Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Val Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ile Pro Phe Gly Asp Trp Trp Tyr Phe Asp Leu Trp Gly Arg 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met Thr Gln Ser 
    130                 135                 140                 


Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
145                 150                 155                 160 


Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
            180                 185                 190         


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Ser Tyr Ser Phe Val Leu Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Val Glu Ile Lys 
                


<210>  264
<211>  248
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-3394/C-582 (MAGE-A3 pep1)

<400>  264

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Leu Tyr Ser Ser Ser Trp Tyr Cys Asp Ala Phe Asp Ile 
            100                 105                 110         


Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Asp Ile Gln Met 
    130                 135                 140                 


Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
145                 150                 155                 160 


Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser 
            180                 185                 190         


Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Ser Trp Ala Ser Thr Pro Leu Thr Phe Gly 
225                 230                 235                 240 


Gly Gly Thr Lys Val Glu Ile Lys 
                245             


<210>  265
<211>  753
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-2753/C-782 (HPV E7 pep2)

<400>  265
gaagtgcagc tggtggaaag cggcggaggc ctggtgaaac ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttctcg aacgcctgga tgagctgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtcggacgg atcaagagca agaccgacgg cggcaccacc      180

gactacgctg cccccgtgaa gggccggttc accatcagcc gggacgacag caagaacacc      240

ctgtacctgc agatgaacag cctgaaaacc gaggacaccg ccgtgtatta ctgtaccacc      300

tcctacgatt accttctcaa tccttatcgt tggaactggt tcgacccctg gggccaggga      360

accctggtca ccgtgtcctc aggcggaggt ggaagcggag ggggaggatc tggcggcgga      420

ggaagcggcg gagacatcca gatgacccag tctccatcct ccctgtctgc atctgtagga      480

gacagagtca ccatcacttg ccgggcaagt cagagcatta gcagctattt aaattggtat      540

cagcagaaac cagggaaagc ccctaagctc ctgatctatg ctgcatccag tttgcaaagt      600

ggggtcccat caaggttcag tggcagtgga tctgggacag atttcactct caccatcagc      660

agtctgcaac ctgaagattt tgcaacttac tactgtcaac agagttacag tacccctctc      720

actttcggcg gcggaacaaa ggtggagatc aag                                   753


<210>  266
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3390/C-2387 (HPV E6 pep1)

<400>  266
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ctggcggcag cctgagactg       60

tcttgcgccg ccagcggctt caccttcagc agctactgga tgcactgggt ccgccaggcc      120

cctggcaagg gactggtctg ggtgtctcga atcaacagcg acggcagcag caccagctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt attactgtgc cagggagaac      300

ggcgtggtga agtggtactt cgacctgtgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagcag cctgagcgcc agcgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatcag cagctacctg aactggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacgc cgccagctcc ctgcagagcg gcgtgccaag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gagttacagt acccctctct ttcccttcgg cggagggacc      720

aaggtggaga tcaaa                                                       735


<210>  267
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3391/C-1043 (HPV E6 pep1)

<400>  267
gaagtgcagc tggtggaaag cggcggaggc ctggtgcagc ccggtcgaag cctgagactg       60

agctgcgccg ccagcggctt cacctttgac gactacgcca tgcactgggt ccgccaggcc      120

cctggcaagg gactggaatg ggtgtccggc atcagctgga acagcggcag catcggctac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acgccaagaa cagcctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccttgt attactgtgc caaggacggc      300

aggggctccc ccttctacgg cggcgccttc gacatctggg gccaagggac aatggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc      480

atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca      540

gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca      600

aggttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct      660

gaagattttg caacttacta ctgtcaacag agttacagta cccctctcac tttcggcggc      720

ggaacaaagg tggagatcaa g                                                741


<210>  268
<211>  732
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3393/C-563 (MAGE-A3 pep1)

<400>  268
caggtgcagc tgcaggaaag cggccctggc ctggtgaaac ccagcgacac cctgagcctg       60

acctgcgccg tgtccggcta cagcatcagc agcagcaatt ggtggggctg gatcagacag      120

ccccctggca agggcctgga atggatcggc tacatctact acagcggcag cacctactac      180

aaccccagcc tgaagtccag agtgaccatg agcgtggaca ccagcaagaa ccagttcagc      240

ctgaagctga gcagcgtgac cgccgtcgat accgctgtgt attactgtgc gagaataccc      300

tttggggatt ggtggtactt cgatctctgg ggccgtggca ccctggtcac tgtgtcctca      360

ggcggaggtg gaagcggagg gggaggatct ggcggcggag gaagcggagg cgacatccag      420

atgacccaga gccccagcag cctgagcgcc agcgtgggcg acagagtgac catcacctgt      480

cgggccagcc agtcgatcag cagctacctg aactggtatc agcagaagcc cggcaaggcc      540

cccaagctgc tgatctacgc cgccagctcc ctgcagagcg gcgtgccaag cagattcagc      600

ggcagcggct ccggcaccga cttcaccctg accatcagca gcctgcagcc cgaggacttc      660

gccacctact actgccagca gagttacagt ttcgttctca ctttcggcgg agggaccaag      720

gtggagatca aa                                                          732


<210>  269
<211>  744
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  C-3394/C-582 (MAGE-A3 pep1)

<400>  269
caggtgcagc tggtgcagtc tggcgccgaa gtgaagaaac ctggcgcctc cgtgaaggtg       60

tcctgcaagg tgtccggcta caccctgacc gagctgtcga tgcactgggt ccgccaggca      120

cctggcaagg gactggaatg gatgggcggc tttgaccccg aggacggcga gacaatctac      180

gcccagaaat tccagggcag agtgaccatg accgaggaca ccagcaccga caccgcctac      240

atggaactga gcagcctgcg gagcgaggac accgctgtgt attactgtgc aacagatctg      300

tatagcagca gctggtactg tgatgctttt gatatctggg gccaagggac aatggtcacc      360

gtgtcctcag gcggaggtgg aagcggaggg ggaggatctg gcggcggagg aagcggaggc      420

gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc      480

atcacctgtc gggccagcca gtcgatcagc agctacctga actggtatca gcagaagccc      540

ggcaaggccc ccaagctgct gatctacgcc gccagctccc tgcagagcgg cgtgccaagc      600

agattcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagcag cctgcagccc      660

gaggacttcg ccacctacta ctgccagcag agttgggcca gcacccctct cactttcggc      720

ggagggacca aggtggagat caaa                                             744


<210>  270
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3

<400>  270

Phe Leu Trp Gly Pro Arg Ala Leu Val 
1               5                   


<210>  271
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MAGE-A3

<400>  271

Met Pro Lys Val Ala Glu Leu Val His Phe Leu 
1               5                   10      


<210>  272
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E6 pMHC

<400>  272

Thr Ile His Asp Ile Ile Leu Glu Cys Val 
1               5                   10  


<210>  273
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  F2A self cleaving peptide

<400>  273

Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys Leu Ala Gly Asp Val 
1               5                   10                  15      


Glu Ser Asn Pro Gly Pro 
            20          


<210>  274
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NY-ESO-1 pMHC

<400>  274

Leu Leu Glu Phe Tyr Leu Ala Met Pro Phe Ala 
1               5                   10      


<210>  275
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  modified NY-ESO-1

<400>  275

Ser Leu Leu Met Trp Ile Thr Gln Val 
1               5                   


<210>  276
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HPV E7 pMHC

<400>  276

Tyr Met Leu Asp Leu Gln Pro Glu Thr 
1               5                   


<210>  277
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1 variant H peptide

<400>  277

Val Leu His Asp Asp Leu Leu Glu Ala 
1               5                   


<210>  278
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2A self-cleaving polypeptide

<400>  278

Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val Glu Glu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210>  279
<211>  608
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-003754 KP7 HA-1H TCRalpha T48C P2A KP7 HA-1H TCRbeta S57C

<400>  279

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Ile Gly Phe Arg Ile 
                245                 250                 255     


Leu Leu Leu Lys Val Ala Gly Phe Asn Leu Leu Met Thr Leu Arg Leu 
            260                 265                 270         


Trp Ser Ser Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala 
        275                 280                 285             


Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Thr Ser Leu Leu Cys 
    290                 295                 300                 


Trp Met Ala Leu Cys Leu Leu Gly Ala Asp His Ala Asp Thr Gly Val 
305                 310                 315                 320 


Ser Gln Asn Pro Arg His Lys Ile Thr Lys Arg Gly Gln Asn Val Thr 
                325                 330                 335     


Phe Arg Cys Asp Pro Ile Ser Glu His Asn Arg Leu Tyr Trp Tyr Arg 
            340                 345                 350         


Gln Thr Leu Gly Gln Gly Pro Glu Phe Leu Thr Tyr Phe Gln Asn Glu 
        355                 360                 365             


Ala Gln Leu Glu Lys Ser Arg Leu Leu Ser Asp Arg Phe Ser Ala Glu 
    370                 375                 380                 


Arg Pro Lys Gly Ser Phe Ser Thr Leu Glu Ile Gln Arg Thr Glu Gln 
385                 390                 395                 400 


Gly Asp Ser Ala Met Tyr Leu Cys Ala Ser Ser Ile Asp Ser Phe Asn 
                405                 410                 415     


Glu Gln Phe Phe Gly Pro Gly Thr Arg Leu Thr Val Leu Glu Asp Leu 
            420                 425                 430         


Lys Asn Val Phe Pro Pro Glu Val Ala Val Phe Glu Pro Ser Glu Ala 
        435                 440                 445             


Glu Ile Ser His Thr Gln Lys Ala Thr Leu Val Cys Leu Ala Thr Gly 
    450                 455                 460                 


Phe Tyr Pro Asp His Val Glu Leu Ser Trp Trp Val Asn Gly Lys Glu 
465                 470                 475                 480 


Val His Ser Gly Val Cys Thr Asp Pro Gln Pro Leu Lys Glu Gln Pro 
                485                 490                 495     


Ala Leu Asn Asp Ser Arg Tyr Cys Leu Ser Ser Arg Leu Arg Val Ser 
            500                 505                 510         


Ala Thr Phe Trp Gln Asn Pro Arg Asn His Phe Arg Cys Gln Val Gln 
        515                 520                 525             


Phe Tyr Gly Leu Ser Glu Asn Asp Glu Trp Thr Gln Asp Arg Ala Lys 
    530                 535                 540                 


Pro Val Thr Gln Ile Val Ser Ala Glu Ala Trp Gly Arg Ala Asp Cys 
545                 550                 555                 560 


Gly Phe Thr Ser Glu Ser Tyr Gln Gln Gly Val Leu Ser Ala Thr Ile 
                565                 570                 575     


Leu Tyr Glu Ile Leu Leu Gly Lys Ala Thr Leu Tyr Ala Val Leu Val 
            580                 585                 590         


Ser Ala Leu Val Leu Met Ala Met Val Lys Arg Lys Asp Ser Arg Gly 
        595                 600                 605             


<210>  280
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR alpha

<400>  280

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser 
                245                 250 


<210>  281
<211>  276
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1(H) TCRbeta

<400>  281

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ile Asp Ser Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser 
        275     


<210>  282
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-003755 KP7 HA-1H FTCRalpha LIR1 TICD

<400>  282

Met Val Lys Ile Arg Gln Phe Leu Leu Ala Ile Leu Trp Leu Gln Leu 
1               5                   10                  15      


Ser Cys Val Ser Ala Ala Lys Asn Glu Val Glu Gln Ser Pro Gln Asn 
            20                  25                  30          


Leu Thr Ala Gln Glu Gly Glu Phe Ile Thr Ile Asn Cys Ser Tyr Ser 
        35                  40                  45              


Val Gly Ile Ser Ala Leu His Trp Leu Gln Gln His Pro Gly Gly Gly 
    50                  55                  60                  


Ile Val Ser Leu Phe Met Leu Ser Ser Gly Lys Lys Lys His Gly Arg 
65                  70                  75                  80  


Leu Ile Ala Thr Ile Asn Ile Gln Glu Lys His Ser Ser Leu His Ile 
                85                  90                  95      


Thr Ala Ser His Pro Arg Asp Ser Ala Val Tyr Ile Cys Ala Val Arg 
            100                 105                 110         


Ser Val Ser Gly Ala Gly Ser Tyr Gln Leu Thr Phe Gly Lys Gly Thr 
        115                 120                 125             


Lys Leu Ser Val Ile Pro Asn Ile Gln Asn Pro Asp Pro Ala Val Tyr 
    130                 135                 140                 


Gln Leu Arg Asp Ser Lys Ser Ser Asp Lys Ser Val Cys Leu Phe Thr 
145                 150                 155                 160 


Asp Phe Asp Ser Gln Thr Asn Val Ser Gln Ser Lys Asp Ser Asp Val 
                165                 170                 175     


Tyr Ile Thr Asp Lys Cys Val Leu Asp Met Arg Ser Met Asp Phe Lys 
            180                 185                 190         


Ser Asn Ser Ala Val Ala Trp Ser Asn Lys Ser Asp Phe Ala Cys Ala 
        195                 200                 205             


Asn Ala Phe Asn Asn Ser Ile Ile Pro Glu Asp Thr Phe Phe Pro Ser 
    210                 215                 220                 


Pro Glu Ser Ser Cys Asp Val Lys Leu Val Glu Lys Ser Phe Glu Thr 
225                 230                 235                 240 


Asp Thr Asn Leu Asn Phe Gln Asn Leu Ser Val Val Ile Gly Ile Leu 
                245                 250                 255     


Val Ala Val Ile Leu Leu Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile 
            260                 265                 270         


Leu Arg His Arg Arg Gln Gly Lys His Trp Thr Ser Thr Gln Arg Lys 
        275                 280                 285             


Ala Asp Phe Gln His Pro Ala Gly Ala Val Gly Pro Glu Pro Thr Asp 
    290                 295                 300                 


Arg Gly Leu Gln Trp Arg Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu 
305                 310                 315                 320 


Asn Leu Tyr Ala Ala Val Lys His Thr Gln Pro Glu Asp Gly Val Glu 
                325                 330                 335     


Met Asp Thr Arg Ser Pro His Asp Glu Asp Pro Gln Ala Val Thr Tyr 
            340                 345                 350         


Ala Glu Val Lys His Ser Arg Pro Arg Arg Glu Met Ala Ser Pro Pro 
        355                 360                 365             


Ser Pro Leu Ser Gly Glu Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu 
    370                 375                 380                 


Glu Asp Arg Gln Met Asp Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln 
385                 390                 395                 400 


Asp Val Thr Tyr Ala Gln Leu His Ser Leu Thr Leu Arg Arg Glu Ala 
                405                 410                 415     


Thr Glu Pro Pro Pro Ser Gln Glu Gly Pro Ser Pro Ala Val Pro Ser 
            420                 425                 430         


Ile Tyr Ala Thr Leu Ala Ile His 
        435                 440 


<210>  283
<211>  466
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-003756 KP7 HA-1H FTCRbeta  LIR1 TICD

<400>  283

Met Gly Thr Ser Leu Leu Cys Trp Met Ala Leu Cys Leu Leu Gly Ala 
1               5                   10                  15      


Asp His Ala Asp Thr Gly Val Ser Gln Asn Pro Arg His Lys Ile Thr 
            20                  25                  30          


Lys Arg Gly Gln Asn Val Thr Phe Arg Cys Asp Pro Ile Ser Glu His 
        35                  40                  45              


Asn Arg Leu Tyr Trp Tyr Arg Gln Thr Leu Gly Gln Gly Pro Glu Phe 
    50                  55                  60                  


Leu Thr Tyr Phe Gln Asn Glu Ala Gln Leu Glu Lys Ser Arg Leu Leu 
65                  70                  75                  80  


Ser Asp Arg Phe Ser Ala Glu Arg Pro Lys Gly Ser Phe Ser Thr Leu 
                85                  90                  95      


Glu Ile Gln Arg Thr Glu Gln Gly Asp Ser Ala Met Tyr Leu Cys Ala 
            100                 105                 110         


Ser Ser Ile Asp Ser Phe Asn Glu Gln Phe Phe Gly Pro Gly Thr Arg 
        115                 120                 125             


Leu Thr Val Leu Glu Asp Leu Lys Asn Val Phe Pro Pro Glu Val Ala 
    130                 135                 140                 


Val Phe Glu Pro Ser Glu Ala Glu Ile Ser His Thr Gln Lys Ala Thr 
145                 150                 155                 160 


Leu Val Cys Leu Ala Thr Gly Phe Tyr Pro Asp His Val Glu Leu Ser 
                165                 170                 175     


Trp Trp Val Asn Gly Lys Glu Val His Ser Gly Val Cys Thr Asp Pro 
            180                 185                 190         


Gln Pro Leu Lys Glu Gln Pro Ala Leu Asn Asp Ser Arg Tyr Cys Leu 
        195                 200                 205             


Ser Ser Arg Leu Arg Val Ser Ala Thr Phe Trp Gln Asn Pro Arg Asn 
    210                 215                 220                 


His Phe Arg Cys Gln Val Gln Phe Tyr Gly Leu Ser Glu Asn Asp Glu 
225                 230                 235                 240 


Trp Thr Gln Asp Arg Ala Lys Pro Val Thr Gln Ile Val Ser Ala Glu 
                245                 250                 255     


Ala Trp Gly Arg Ala Asp Cys Gly Phe Thr Ser Glu Ser Tyr Gln Gln 
            260                 265                 270         


Gly Val Leu Ser Val Val Ile Gly Ile Leu Val Ala Val Ile Leu Leu 
        275                 280                 285             


Leu Leu Leu Leu Leu Leu Leu Phe Leu Ile Leu Arg His Arg Arg Gln 
    290                 295                 300                 


Gly Lys His Trp Thr Ser Thr Gln Arg Lys Ala Asp Phe Gln His Pro 
305                 310                 315                 320 


Ala Gly Ala Val Gly Pro Glu Pro Thr Asp Arg Gly Leu Gln Trp Arg 
                325                 330                 335     


Ser Ser Pro Ala Ala Asp Ala Gln Glu Glu Asn Leu Tyr Ala Ala Val 
            340                 345                 350         


Lys His Thr Gln Pro Glu Asp Gly Val Glu Met Asp Thr Arg Ser Pro 
        355                 360                 365             


His Asp Glu Asp Pro Gln Ala Val Thr Tyr Ala Glu Val Lys His Ser 
    370                 375                 380                 


Arg Pro Arg Arg Glu Met Ala Ser Pro Pro Ser Pro Leu Ser Gly Glu 
385                 390                 395                 400 


Phe Leu Asp Thr Lys Asp Arg Gln Ala Glu Glu Asp Arg Gln Met Asp 
                405                 410                 415     


Thr Glu Ala Ala Ala Ser Glu Ala Pro Gln Asp Val Thr Tyr Ala Gln 
            420                 425                 430         


Leu His Ser Leu Thr Leu Arg Arg Glu Ala Thr Glu Pro Pro Pro Ser 
        435                 440                 445             


Gln Glu Gly Pro Ser Pro Ala Val Pro Ser Ile Tyr Ala Thr Leu Ala 
    450                 455                 460                 


Ile His 
465     


<210>  284
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CYBA-1Y peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Tyr or His

<400>  284

Ser Thr Met Glu Arg Trp Gly Gln Lys Xaa 
1               5                   10  


<210>  285
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-OAS1-1R


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Arg or Thr

<400>  285

Glu Thr Asp Asp Pro Arg Xaa Tyr Gln Lys Tyr 
1               5                   10      


<210>  286

<400>  286
000

<210>  287
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-2 peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Val or Met

<400>  287

Tyr Ile Gly Glu Val Leu Val Ser Xaa 
1               5                   


<210>  288
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-8 peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Arg or Pro

<400>  288

Xaa Thr Leu Asp Lys Val Leu Glu Val 
1               5                   


<210>  289
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-3 peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Thr or Met

<400>  289

Val Xaa Glu Pro Gly Thr Ala Gln Tyr 
1               5                   


<210>  290
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HwA11-S peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Thr

<400>  290

Cys Ile Pro Pro Asp Xaa Leu Leu Phe Pro Ala 
1               5                   10      


<210>  291
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ADIR-1F peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Phe or Ser

<400>  291

Ser Val Ala Pro Ala Leu Ala Leu Xaa Pro Ala 
1               5                   10      


<210>  292
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-HIVEP1-1S peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ser or Asn

<400>  292

Ser Leu Pro Lys His Xaa Val Thr Ile 
1               5                   


<210>  293
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NISCH-1A peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ala or Val

<400>  293

Ala Leu Ala Pro Ala Pro Xaa Glu Val 
1               5                   


<210>  294
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SSR1-1S peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Ser or Leu

<400>  294

Xaa Leu Ala Val Ala Gln Asp Leu Thr 
1               5                   


<210>  295
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-WNK1-1I peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ile or Met

<400>  295

Arg Thr Leu Ser Pro Glu Xaa Ile Thr Val 
1               5                   10  


<210>  296
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  T4A peptide


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Ala or Glu

<400>  296

Gly Leu Tyr Thr Tyr Trp Ser Ala Gly Xaa 
1               5                   10  


<210>  297
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTA2-1 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Leu or Pro

<400>  297

Gln Leu Xaa Asn Ser Val Leu Thr Leu 
1               5                   


<210>  298
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CLYBL-1Y peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr or Asp

<400>  298

Ser Leu Ala Ala Xaa Ile Pro Arg Leu 
1               5                   


<210>  299
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TRIM22 peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Cys or Arg

<400>  299

Met Ala Val Pro Pro Cys Xaa Ile Gly Val 
1               5                   10  


<210>  300
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PARP10-1L peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Leu or Pro

<400>  300

Gly Leu Xaa Gly Gln Glu Gly Leu Val Glu Ile 
1               5                   10      


<210>  301
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FAM119A-1T peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Thr or Ile

<400>  301

Ala Met Leu Glu Arg Gln Phe Xaa Val 
1               5                   


<210>  302
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GLRX3-1S peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Pro

<400>  302

Phe Leu Xaa Ser Ala Asn Glu His Leu 
1               5                   


<210>  303
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HNF4G-1M peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Met or Ile

<400>  303

Met Xaa Tyr Lys Asp Ile Leu Leu Leu 
1               5                   


<210>  304
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMMR-1V peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Val or Ala

<400>  304

Ser Leu Gln Glu Lys Xaa Ala Lys Ala 
1               5                   


<210>  305
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BCL2A1 peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asn or Lys

<400>  305

Val Leu Gln Xaa Val Ala Phe Ser Val 
1               5                   


<210>  306
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDC26-1F peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Phe or Ser

<400>  306

Xaa Val Ala Gly Thr Gln Glu Val Phe Val 
1               5                   10  


<210>  307
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3F-1S/A peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Ala

<400>  307

Phe Leu Xaa Glu His Pro Asn Val Thr Leu 
1               5                   10  


<210>  308
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PRCP-1D peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Asp or Glu

<400>  308

Phe Met Trp Asp Val Ala Glu Xaa Leu 
1               5                   


<210>  309
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PRCP-1D peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Asp or Glu

<400>  309

Phe Met Trp Asp Val Ala Glu Xaa Leu Lys Ala 
1               5                   10      


<210>  310
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-CCL4-1T peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Thr or Ser

<400>  310

Cys Ala Asp Pro Ser Glu Xaa Trp Val 
1               5                   


<210>  311
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NCAPD3-1Q peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Gln or Arg

<400>  311

Trp Leu Xaa Gly Val Val Pro Val Val 
1               5                   


<210>  312
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NDC80-1P peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Pro or Ala

<400>  312

His Leu Glu Glu Gln Ile Xaa Lys Val 
1               5                   


<210>  313
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TTK-1D peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Asp or Glu

<400>  313

Arg Leu His Xaa Gly Arg Val Phe Val 
1               5                   


<210>  314
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WDR27-1L peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Leu or Pro

<400>  314

Ser Xaa Asp Asp His Val Val Ala Val 
1               5                   


<210>  315
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIIP peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Lys or Glu

<400>  315

Ser Glu Glu Ser Ala Val Pro Xaa Arg Ser Trp 
1               5                   10      


<210>  316
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MIIP peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<400>  316

Glu Glu Ser Ala Val Pro Xaa Arg Ser Trp 
1               5                   10  


<210>  317
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-DHX33-1C peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Cys or Arg

<400>  317

Tyr Leu Tyr Glu Gly Gly Ile Ser Xaa 
1               5                   


<210>  318
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PANE1 peptide

<400>  318

Arg Val Trp Asp Leu Pro Gly Val Leu Lys 
1               5                   10  


<210>  319
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SP110 peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Arg or Gly

<400>  319

Ser Leu Pro Xaa Gly Thr Ser Thr Pro Lys 
1               5                   10  


<210>  320
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-1C/Y


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Tyr or Cys

<400>  320

Asp Tyr Leu Gln Xaa Val Leu Gln Ile 
1               5                   


<210>  321
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  P2RX7 peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is His or Arg

<400>  321

Trp Phe His His Cys Xaa Pro Lys Tyr 
1               5                   


<210>  322
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-4 peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Arg or Gly

<400>  322

Ala Thr Leu Pro Leu Leu Cys Ala Xaa 
1               5                   


<210>  323
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-5


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Arg or Gly

<400>  323

Trp Ala Thr Leu Pro Leu Leu Cys Ala Xaa 
1               5                   10  


<210>  324
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AKAP13 peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Met or Thr

<400>  324

Ala Pro Ala Gly Val Arg Glu Val Xaa 
1               5                   


<210>  325
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-APOBEC3B-1K peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Lys or Glu

<400>  325

Xaa Pro Gln Tyr His Ala Glu Met Cys Phe 
1               5                   10  


<210>  326
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  APOBEC3H peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Lys or Glu

<400>  326

Lys Pro Gln Gln Xaa Gly Leu Arg Leu 
1               5                   


<210>  327
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ARHGDIB-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Arg or Phe

<400>  327

Pro Arg Ala Cys Trp Xaa Glu Ala 
1               5               


<210>  328
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-BCAT2-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg or Thr

<400>  328

Gln Pro Xaa Arg Ala Leu Leu Phe Val Ile 
1               5                   10  


<210>  329
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  BFAR peptide


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Met or Arg

<400>  329

Ala Pro Asn Thr Gly Arg Ala Asn Gln Gln Xaa 
1               5                   10      


<210>  330
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C14orf169 peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Ala or Val

<400>  330

Arg Pro Arg Xaa Pro Thr Glu Glu Leu Ala Leu 
1               5                   10      


<210>  331
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-C16ORF-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Arg or Trp

<400>  331

Xaa Pro Cys Pro Ser Val Gly Leu Ser Phe Leu 
1               5                   10      


<210>  332
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C18orf21 peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Ala or Thr

<400>  332

Asn Pro Ala Thr Pro Xaa Ser Lys Leu 
1               5                   


<210>  333
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-EBI3-1I peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ile or Val

<400>  333

Arg Pro Arg Ala Arg Tyr Tyr Xaa Gln Val 
1               5                   10  


<210>  334
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  POP1 peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asn or Lys

<400>  334

Leu Pro Gln Lys Lys Ser Xaa Ala Leu 
1               5                   


<210>  335
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SCRIB peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Leu or Pro

<400>  335

Leu Pro Gln Gln Pro Pro Xaa Ser Leu 
1               5                   


<210>  336
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MTRR peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Ser or Leu

<400>  336

Ser Pro Ala Ser Xaa Arg Thr Asp Leu 
1               5                   


<210>  337
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LLGL2


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Arg or His

<400>  337

Ser Pro Ser Leu Xaa Ile Leu Ala Ile 
1               5                   


<210>  338
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ECGF-1H peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is His or Arg

<400>  338

Arg Pro Xaa Ala Ile Arg Arg Pro Leu Ala Leu 
1               5                   10      


<210>  339
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ERAP1-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg or Pro

<400>  339

His Pro Xaa Gln Glu Gln Ile Ala Leu Leu Ala 
1               5                   10      


<210>  340
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ERAP1-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Arg or Pro

<400>  340

His Pro Xaa Gln Glu Gln Ile Ala Leu 
1               5                   


<210>  341
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-FUCA2-1V peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is Val or Met

<400>  341

Arg Leu Arg Gln Xaa Gly Ser Trp Leu 
1               5                   


<210>  342
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-GEMIN4-1V peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Val or Glu

<400>  342

Phe Pro Ala Leu Arg Phe Val Glu Xaa 
1               5                   


<210>  343
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HDGF peptide


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Leu or Pro

<400>  343

Leu Pro Met Glu Val Glu Lys Asn Ser Thr Xaa 
1               5                   10      


<210>  344
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PDCD11-1F peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Phe or Leu

<400>  344

Gly Pro Asp Ser Ser Lys Thr Xaa Leu Cys Leu 
1               5                   10      


<210>  345
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-PFAS-1P peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Pro or Ser

<400>  345

Ala Xaa Gly His Thr Arg Arg Lys Leu 
1               5                   


<210>  346
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TEP1-1S peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is Ser or Pro

<400>  346

Ala Pro Asp Gly Ala Lys Val Ala Xaa Leu 
1               5                   10  


<210>  347
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TMEM8A-1I peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Ile or Val

<400>  347

Arg Pro Arg Ser Val Thr Xaa Gln Pro Leu Leu 
1               5                   10      


<210>  348
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-USP15-1I peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Ile or Thr

<400>  348

Met Pro Ser His Leu Arg Asn Xaa Leu Leu 
1               5                   10  


<210>  349
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LRH-1 peptide

<400>  349

Thr Pro Asn Gln Arg Gln Asn Val Cys 
1               5                   


<210>  350
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-MOB3A-1C peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Cys or Ser

<400>  350

Xaa Pro Arg Pro Gly Thr Trp Thr Cys 
1               5                   


<210>  351
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ZDHHC6-1Y peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Tyr or His

<400>  351

Arg Pro Arg Xaa Trp Ile Leu Leu Val Lys Ile 
1               5                   10      


<210>  352
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ZAPHIR peptide

<400>  352

Ile Pro Arg Asp Ser Trp Trp Val Glu Leu 
1               5                   10  


<210>  353
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HEATR1 peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Glu or Gly

<400>  353

Ile Ser Lys Glu Arg Ala Xaa Ala Leu 
1               5                   


<210>  354
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-GSTP1-1V peptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Val or Ile

<400>  354

Asp Leu Arg Cys Lys Tyr Xaa Ser Leu 
1               5                   


<210>  355
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HA-1/B60 peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is His or Arg

<400>  355

Lys Glu Cys Val Leu Xaa Asp Asp Leu 
1               5                   


<210>  356
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SON-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Arg or Cys

<400>  356

Ser Glu Thr Lys Gln Xaa Thr Val Leu 
1               5                   


<210>  357
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-SWAP70-1Q peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Gln or Glu

<400>  357

Met Glu Gln Leu Glu Xaa Leu Glu Leu 
1               5                   


<210>  358
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-TRIP10-1EPC peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Glu or Gly

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Pro or Ser

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Cys or Gly

<400>  358

Gly Xaa Xaa Gln Asp Leu Xaa Thr Leu 
1               5                   


<210>  359
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-NUP133-1R peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg or Gln

<400>  359

Ser Glu Asp Leu Ile Leu Cys Xaa Leu 
1               5                   


<210>  360
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LB-ZNFX1-1Q peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Gln or His

<400>  360

Asn Glu Ile Glu Asp Val Trp Xaa Leu Asp Leu 
1               5                   10      


<210>  361
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SLC1A5 peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ala or Pro

<400>  361

Ala Glu Xaa Thr Ala Asn Gly Gly Leu Ala Leu 
1               5                   10      


<210>  362
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-2 peptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Asp or Gly

<400>  362

Lys Glu Phe Glu Asp Xaa Ile Ile Asn Trp 
1               5                   10  


<210>  363
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ACC-6 peptide

<400>  363

Met Glu Ile Phe Ile Glu Val Phe Ser His Phe 
1               5                   10      


<210>  364
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HB-1H/Y peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is His or Tyr

<400>  364

Glu Glu Lys Arg Gly Ser Leu Xaa Val Trp 
1               5                   10  


<210>  365
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DPH1 peptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Val or Leu

<400>  365

Ser Xaa Leu Pro Glu Val Asp Val Trp 
1               5                   


<210>  366
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/A02 peptide

<400>  366

Cys Val Ala Thr Met Ile Phe Met Ile 
1               5                   


<210>  367
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/A29

<400>  367

Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr 
1               5                   10  


<210>  368
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UGT2B17/B44 peptide

<400>  368

Ala Glu Leu Leu Asn Ile Pro Phe Leu Tyr 
1               5                   10  


<210>  369
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DFFRY peptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Cys or Ser

<400>  369

Ile Val Asp Xaa Leu Thr Glu Met Tyr 
1               5                   


<210>  370
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SMCY peptide

<400>  370

Phe Ile Asp Ser Tyr Ile Cys Gln Val 
1               5                   


<210>  371
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TMSB4Y peptide

<400>  371

Glu Val Leu Leu Arg Pro Gly Leu His Phe Arg 
1               5                   10      


<210>  372
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SMCY peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is Ser or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Arg or Gln

<400>  372

Ser Pro Xaa Val Asp Lys Ala Xaa Ala Glu Leu 
1               5                   10      


<210>  373
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTY peptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is His or Arg

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Asp or Asn

<400>  373

Leu Pro His Asn Xaa Thr Xaa Leu 
1               5               


<210>  374
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RPSY peptide


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Val or Leu

<400>  374

Thr Ile Arg Tyr Pro Asp Pro Xaa Ile 
1               5                   


<210>  375
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  UTY peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is Arg or Gly

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is Glu or Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is Val or Pro

<400>  375

Xaa Glu Ser Glu Glu Xaa Ser Xaa Ser Leu 
1               5                   10  


<210>  376

<400>  376
000

<210>  377
<211>  1827
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1(H) TCR alpha and beta

<400>  377
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gtgattgggt tccgaatcct cctcctgaaa      780

gtggccgggt ttaatctgct catgacgctg cggctgtggt ccagcggatc cggagccacc      840

aacttcagcc tgctgaagca ggccggcgac gtggaggaga accccggccc catgggcacc      900

agcctcctct gctggatggc cctgtgtctc ctgggggcag atcacgcaga tactggagtc      960

tcccagaacc ccagacacaa gatcacaaag aggggacaga atgtaacttt caggtgtgat     1020

ccaatttctg aacacaaccg cctttattgg taccgacaga ccctggggca gggcccagag     1080

tttctgactt acttccagaa tgaagctcaa ctagaaaaat caaggctgct cagtgatcgg     1140

ttctctgcag agaggcctaa gggatctttc tccaccttgg agatccagcg cacagagcag     1200

ggggactcgg ccatgtatct ctgtgccagc agcatcgact ccttcaacga gcagttcttc     1260

gggccgggca ccaggctcac ggtcctcgag gacctgaaaa acgtgttccc acccgaggtc     1320

gctgtgtttg agccatcaga agcagagatc tcccacaccc aaaaggccac actggtgtgc     1380

ctggccacag gcttctaccc cgaccacgtg gagctgagct ggtgggtgaa tgggaaggag     1440

gtgcacagtg gggtctgcac agacccgcag cccctcaagg agcagcccgc cctcaatgac     1500

tccagatact gcctgagcag ccgcctgagg gtgtcggcca ccttctggca gaacccccgc     1560

aaccacttcc gctgtcaagt ccagttctac gggctctcgg agaatgacga gtggacccag     1620

gatagggcca aacctgtcac ccagatcgtc agcgccgagg cctggggtag agcagactgt     1680

ggcttcacct ccgagtctta ccagcaaggg gtcctgtctg ccaccatcct ctatgagatc     1740

ttgctaggga aggccacctt gtatgccgtg ctggtcagtg ccctcgtgct gatggccatg     1800

gtcaagagaa aggattccag aggctag                                         1827


<210>  378
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR alpha

<400>  378
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca                                       750


<210>  379
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  HA-1H TCR beta

<400>  379
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

actggagtct cccagaaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc      120

aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag      180

ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc      240

agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc      300

acagagcagg gggactcggc catgtatctc tgtgccagca gcatcgactc cttcaacgag      360

cagttcttcg ggccgggcac caggctcacg gtcctcgagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtct                   828


<210>  380
<211>  1279
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ftcr alpha LIR1 HA-1H

<400>  380
atggtgaaga tccggcaatt tttgttggct attttgtggc ttcagctaag ctgtgtaagt       60

gccgccaaaa atgaagtgga gcagagtcct cagaacctga ctgcccagga aggagaattt      120

atcacaatca actgcagtta ctcggtagga ataagtgcct tacactggct gcaacagcat      180

ccaggaggag gcattgtttc cttgtttatg ctgagctcag ggaagaagaa gcatggaaga      240

ttaattgcca caataaacat acaggaaaag cacagctccc tgcacatcac agcctcccat      300

cccagagact ctgccgtcta catctgtgct gtcagaagcg tgtccggggc cggctcctac      360

cagctcacct ttgggaaggg gaccaaatta tcagtcattc caaatatcca gaaccctgac      420

cctgccgtgt accagctgag agactctaaa tccagtgaca agtctgtctg cctattcacc      480

gattttgatt ctcaaacaaa tgtgtcacaa agtaaggatt ctgatgtgta tatcacagac      540

aaatgtgtgc tagacatgag gtctatggac ttcaagagca acagtgctgt ggcctggagc      600

aacaaatctg actttgcatg tgcaaacgcc ttcaacaaca gcattattcc agaagacacc      660

ttcttcccca gcccagaaag ttcctgtgat gtcaagctgg tcgagaaaag ctttgaaaca      720

gatacgaacc taaactttca aaacctgtca gttgtgatcg gcatcttggt ggccgtcatc      780

ctactgctcc tcctcctcct cctcctcttc ctcatcctcc gacatcgacg tcagggcaaa      840

cactggacat cgacccagag aaaggctgat ttccaacatc ctgcaggggc tgtggggcca      900

gagcccacag acagaggcct gcagtggagg tccagcccag ctgccgatgc ccaggaagaa      960

aacctctatg ctgccgtgaa gcacacacag cctgaggatg gggtggagat ggacactcgg     1020

agcccacacg atgaagaccc ccaggcagtg acgtatgccg aggtgaaaca ctccagacct     1080

aggagagaaa tggcctctcc tccttcccca ctgtctgggg aattcctgga cacaaaggac     1140

agacaggcgg aagaggacag gcagatggac actgaggctg ctgcatctga agccccccag     1200

gatgtgacct acgcccagct gcacagcttg accctcagac gggaggcaac tgagcctcct     1260

ccatcccagg aagggccct                                                  1279


<210>  381
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ftcr beta LIR1 HA-1H

<400>  381
atgggcacca gcctcctctg ctggatggcc ctgtgtctcc tgggggcaga tcacgcagat       60

actggagtct cccagaaccc cagacacaag atcacaaaga ggggacagaa tgtaactttc      120

aggtgtgatc caatttctga acacaaccgc ctttattggt accgacagac cctggggcag      180

ggcccagagt ttctgactta cttccagaat gaagctcaac tagaaaaatc aaggctgctc      240

agtgatcggt tctctgcaga gaggcctaag ggatctttct ccaccttgga gatccagcgc      300

acagagcagg gggactcggc catgtatctc tgtgccagca gcatcgactc cttcaacgag      360

cagttcttcg ggccgggcac caggctcacg gtcctcgagg acctgaaaaa cgtgttccca      420

cccgaggtcg ctgtgtttga gccatcagaa gcagagatct cccacaccca aaaggccaca      480

ctggtgtgcc tggccacagg cttctacccc gaccacgtgg agctgagctg gtgggtgaat      540

gggaaggagg tgcacagtgg ggtctgcaca gacccgcagc ccctcaagga gcagcccgcc      600

ctcaatgact ccagatactg cctgagcagc cgcctgaggg tgtcggccac cttctggcag      660

aacccccgca accacttccg ctgtcaagtc cagttctacg ggctctcgga gaatgacgag      720

tggacccagg atagggccaa acctgtcacc cagatcgtca gcgccgaggc ctggggtaga      780

gcagactgtg gcttcacctc cgagtcttac cagcaagggg tcctgtctgt tgtgatcggc      840

atcttggtgg ccgtcatcct actgctcctc ctcctcctcc tcctcttcct catcctccga      900

catcgacgtc agggcaaaca ctggacatcg acccagagaa aggctgattt ccaacatcct      960

gcaggggctg tggggccaga gcccacagac agaggcctgc agtggaggtc cagcccagct     1020

gccgatgccc aggaagaaaa cctctatgct gccgtgaagc acacacagcc tgaggatggg     1080

gtggagatgg acactcggag cccacacgat gaagaccccc aggcagtgac gtatgccgag     1140

gtgaaacact ccagacctag gagagaaatg gcctctcctc cttccccact gtctggggaa     1200

ttcctggaca caaaggacag acaggcggaa gaggacaggc agatggacac tgaggctgct     1260

gcatctgaag ccccccagga tgtgacctac gcccagctgc acagcttgac cctcagacgg     1320

gaggcaactg agcctcctcc atcccaggaa gggccctctc cagctgtgcc cagcatctac     1380

gccactctgg ccatccacta g                                               1401


