                         SEQUENCE LISTING

<110>  AVM BIOTECHNOLOGY, LLC
 
<120>  NOVEL THERAPIES

<130>  01173-0023-00PCT

<140>  PCT/US2021/029608
<141>  2021-04-28

<160>  5     

<170>  PatentIn version 3.5

<210>  1
<211>  404
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CD209_HUMAN

<400>  1

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Thr Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Thr Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210>  2
<211>  1333
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus 2


<220>
<221>  misc_feature
<223>  SPIKE_SARS2

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly 
        595                 600                 605             


Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln 
    610                 615                 620                 


Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln 
625                 630                 635                 640 


Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser 
                645                 650                 655     


Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr 
            660                 665                 670         


Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln 
        675                 680                 685             


Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln 
    690                 695                 700                 


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
705                 710                 715                 720 


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
                725                 730                 735     


Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile 
            740                 745                 750         


Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser 
        755                 760                 765             


Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr 
    770                 775                 780                 


Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met 
785                 790                 795                 800 


Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr 
                805                 810                 815     


Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val 
            820                 825                 830         


Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile 
        835                 840                 845             


Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln 
    850                 855                 860                 


Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp 
865                 870                 875                 880 


Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln 
                885                 890                 895     


Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala 
            900                 905                 910         


Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu 
        915                 920                 925             


Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser 
    930                 935                 940                 


Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met 
945                 950                 955                 960 


Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu 
                965                 970                 975     


Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly 
            980                 985                 990         


Lys Ile Gln Asp Ser Leu Ser Ser  Thr Ala Ser Ala Leu  Gly Lys Leu 
        995                 1000                 1005             


Gln Asp  Val Val Asn Gln Asn  Ala Gln Ala Leu Asn  Thr Leu Val 
    1010                 1015                 1020             


Lys Gln  Leu Ser Ser Asn Phe  Gly Ala Ile Ser Ser  Val Leu Asn 
    1025                 1030                 1035             


Asp Ile  Leu Ser Arg Leu Asp  Lys Val Glu Ala Glu  Val Gln Ile 
    1040                 1045                 1050             


Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
    1055                 1060                 1065             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1070                 1075                 1080             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1085                 1090                 1095             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1100                 1105                 1110             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1115                 1120                 1125             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1130                 1135                 1140             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1145                 1150                 1155             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1160                 1165                 1170             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1175                 1180                 1185             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1190                 1195                 1200             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1205                 1210                 1215             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1220                 1225                 1230             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1235                 1240                 1245             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1250                 1255                 1260             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1265                 1270                 1275             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1280                 1285                 1290             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1295                 1300                 1305             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1310                 1315                 1320             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1325                 1330             


<210>  3
<211>  399
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  CLC4M_HUMAN

<400>  3

Met Ser Asp Ser Lys Glu Pro Arg Val Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Asp Pro Thr Thr Ser Gly Ile Arg Leu Phe Pro Arg Asp Phe Gln 
            20                  25                  30          


Phe Gln Gln Ile His Gly His Lys Ser Ser Thr Gly Cys Leu Gly His 
        35                  40                  45              


Gly Ala Leu Val Leu Gln Leu Leu Ser Phe Met Leu Leu Ala Gly Val 
    50                  55                  60                  


Leu Val Ala Ile Leu Val Gln Val Ser Lys Val Pro Ser Ser Leu Ser 
65                  70                  75                  80  


Gln Glu Gln Ser Glu Gln Asp Ala Ile Tyr Gln Asn Leu Thr Gln Leu 
                85                  90                  95      


Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys Leu Gln Glu Ile 
            100                 105                 110         


Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        115                 120                 125             


Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    130                 135                 140                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln 
145                 150                 155                 160 


Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser 
                165                 170                 175     


Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val 
            180                 185                 190         


Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu 
        195                 200                 205             


Thr Glu Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu 
    210                 215                 220                 


Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly Glu 
225                 230                 235                 240 


Leu Pro Asp Gln Ser Lys Gln Gln Gln Ile Tyr Gln Glu Leu Thr Asp 
                245                 250                 255     


Leu Lys Thr Ala Phe Glu Arg Leu Cys Arg His Cys Pro Lys Asp Trp 
            260                 265                 270         


Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn Ser Gln Arg Asn 
        275                 280                 285             


Trp His Asp Ser Val Thr Ala Cys Gln Glu Val Arg Ala Gln Leu Val 
    290                 295                 300                 


Val Ile Lys Thr Ala Glu Glu Gln Asn Phe Leu Gln Leu Gln Thr Ser 
305                 310                 315                 320 


Arg Ser Asn Arg Phe Ser Trp Met Gly Leu Ser Asp Leu Asn Gln Glu 
                325                 330                 335     


Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Ser Pro Ser Phe Gln 
            340                 345                 350         


Arg Tyr Trp Asn Ser Gly Glu Pro Asn Asn Ser Gly Asn Glu Asp Cys 
        355                 360                 365             


Ala Glu Phe Ser Gly Ser Gly Trp Asn Asp Asn Arg Cys Asp Val Asp 
    370                 375                 380                 


Asn Tyr Trp Ile Cys Lys Lys Pro Ala Ala Cys Phe Arg Asp Glu 
385                 390                 395                 


<210>  4
<211>  1315
<212>  PRT
<213>  Severe acute respiratory syndrome coronavirus


<220>
<221>  misc_feature
<223>  SPIKE_CVHSA

<400>  4

Met Phe Ile Phe Leu Leu Phe Leu Thr Leu Thr Ser Gly Ser Asp Leu 
1               5                   10                  15      


Asp Arg Cys Thr Thr Phe Asp Asp Val Gln Ala Pro Asn Tyr Thr Gln 
            20                  25                  30          


His Thr Ser Ser Met Arg Gly Val Tyr Tyr Pro Asp Glu Ile Phe Arg 
        35                  40                  45              


Ser Asp Thr Leu Tyr Leu Thr Gln Asp Leu Phe Leu Pro Phe Tyr Ser 
    50                  55                  60                  


Asn Val Thr Gly Phe His Thr Ile Asn His Thr Phe Gly Asn Pro Val 
65                  70                  75                  80  


Ile Pro Phe Lys Asp Gly Ile Tyr Phe Ala Ala Thr Glu Lys Ser Asn 
                85                  90                  95      


Val Val Arg Gly Trp Val Phe Gly Ser Thr Met Asn Asn Lys Ser Gln 
            100                 105                 110         


Ser Val Ile Ile Ile Asn Asn Ser Thr Asn Val Val Ile Arg Ala Cys 
        115                 120                 125             


Asn Phe Glu Leu Cys Asp Asn Pro Phe Phe Ala Val Ser Lys Pro Met 
    130                 135                 140                 


Gly Thr Gln Thr His Thr Met Ile Phe Asp Asn Ala Phe Asn Cys Thr 
145                 150                 155                 160 


Phe Glu Tyr Ile Ser Asp Ala Phe Ser Leu Asp Val Ser Glu Lys Ser 
                165                 170                 175     


Gly Asn Phe Lys His Leu Arg Glu Phe Val Phe Lys Asn Lys Asp Gly 
            180                 185                 190         


Phe Leu Tyr Val Tyr Lys Gly Tyr Gln Pro Ile Asp Val Val Arg Asp 
        195                 200                 205             


Leu Pro Ser Gly Phe Asn Thr Leu Lys Pro Ile Phe Lys Leu Pro Leu 
    210                 215                 220                 


Gly Ile Asn Ile Thr Asn Phe Arg Ala Ile Leu Thr Ala Phe Ser Pro 
225                 230                 235                 240 


Ala Gln Asp Ile Trp Gly Thr Ser Ala Ala Ala Tyr Phe Val Gly Tyr 
                245                 250                 255     


Leu Lys Pro Thr Thr Phe Met Leu Lys Tyr Asp Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ser Gln Asn Pro Leu Ala Glu Leu Lys Cys 
        275                 280                 285             


Ser Val Lys Ser Phe Glu Ile Asp Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Val Pro Ser Gly Asp Val Val Arg Phe Pro Asn Ile Thr 
305                 310                 315                 320 


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Lys Phe Pro Ser 
                325                 330                 335     


Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser Asn Cys Val Ala Asp Tyr 
            340                 345                 350         


Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser Thr Phe Lys Cys Tyr Gly 
        355                 360                 365             


Val Ser Ala Thr Lys Leu Asn Asp Leu Cys Phe Ser Asn Val Tyr Ala 
    370                 375                 380                 


Asp Ser Phe Val Val Lys Gly Asp Asp Val Arg Gln Ile Ala Pro Gly 
385                 390                 395                 400 


Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
                405                 410                 415     


Met Gly Cys Val Leu Ala Trp Asn Thr Arg Asn Ile Asp Ala Thr Ser 
            420                 425                 430         


Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr Leu Arg His Gly Lys Leu 
        435                 440                 445             


Arg Pro Phe Glu Arg Asp Ile Ser Asn Val Pro Phe Ser Pro Asp Gly 
    450                 455                 460                 


Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys Tyr Trp Pro Leu Asn Asp 
465                 470                 475                 480 


Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly Tyr Gln Pro Tyr Arg Val 
                485                 490                 495     


Val Val Leu Ser Phe Glu Leu Leu Asn Ala Pro Ala Thr Val Cys Gly 
            500                 505                 510         


Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn Gln Cys Val Asn Phe Asn 
        515                 520                 525             


Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg 
    530                 535                 540                 


Phe Gln Pro Phe Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp 
545                 550                 555                 560 


Ser Val Arg Asp Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys 
                565                 570                 575     


Ser Phe Gly Gly Val Ser Gln Cys Val Asn Phe Asn Phe Asn Gly Leu 
            580                 585                 590         


Thr Gly Thr Gly Val Leu Thr Pro Ser Ser Lys Arg Phe Gln Pro Phe 
        595                 600                 605             


Gln Gln Phe Gly Arg Asp Val Ser Asp Phe Thr Asp Ser Val Arg Asp 
    610                 615                 620                 


Pro Lys Thr Ser Glu Ile Leu Asp Ile Ser Pro Cys Ser Phe Gly Gly 
625                 630                 635                 640 


Val Ser Val Ile Thr Pro Gly Thr Asn Ala Ser Ser Glu Val Ala Val 
                645                 650                 655     


Leu Tyr Gln Asp Val Asn Cys Thr Asp Val Ser Thr Ala Ile His Ala 
            660                 665                 670         


Asp Gln Leu Thr Pro Ala Trp Arg Ile Tyr Ser Thr Gly Asn Asn Val 
        675                 680                 685             


Phe Gln Thr Gln Ala Gly Cys Leu Ile Gly Ala Glu His Val Asp Thr 
    690                 695                 700                 


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
705                 710                 715                 720 


His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln Lys Ser Ile Val Ala 
                725                 730                 735     


Tyr Thr Met Ser Leu Gly Ala Asp Ser Ser Ile Ala Tyr Ser Asn Asn 
            740                 745                 750         


Thr Ile Ala Ile Pro Thr Asn Phe Ser Ile Ser Ile Thr Thr Glu Val 
        755                 760                 765             


Met Pro Val Ser Met Ala Lys Thr Ser Val Asp Cys Asn Met Tyr Ile 
    770                 775                 780                 


Cys Gly Asp Ser Thr Glu Cys Ala Asn Leu Leu Leu Gln Tyr Gly Ser 
785                 790                 795                 800 


Phe Cys Thr Gln Leu Asn Arg Ala Leu Ser Gly Ile Ala Ala Glu Gln 
                805                 810                 815     


Asp Arg Asn Thr Arg Glu Val Phe Ala Gln Val Lys Gln Met Tyr Lys 
            820                 825                 830         


Thr Pro Thr Leu Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu 
        835                 840                 845             


Pro Asp Pro Leu Lys Pro Thr Lys Arg Ser Phe Ile Glu Asp Leu Leu 
    850                 855                 860                 


Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Met Lys Gln Tyr Gly 
865                 870                 875                 880 


Glu Cys Leu Gly Asp Ile Asn Ala Arg Asp Leu Ile Cys Ala Gln Lys 
                885                 890                 895     


Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Asp Met Ile 
            900                 905                 910         


Ala Ala Tyr Thr Ala Ala Leu Val Ser Gly Thr Ala Thr Ala Gly Trp 
        915                 920                 925             


Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met 
    930                 935                 940                 


Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu 
945                 950                 955                 960 


Asn Gln Lys Gln Ile Ala Asn Gln Phe Asn Lys Ala Ile Ser Gln Ile 
                965                 970                 975     


Gln Glu Ser Leu Thr Thr Thr Ser Thr Ala Leu Gly Lys Leu Gln Asp 
            980                 985                 990         


Val Val Asn Gln Asn Ala Gln Ala  Leu Asn Thr Leu Val  Lys Gln Leu 
        995                 1000                 1005             


Ser Ser  Asn Phe Gly Ala Ile  Ser Ser Val Leu Asn  Asp Ile Leu 
    1010                 1015                 1020             


Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val Gln Ile  Asp Arg Leu 
    1025                 1030                 1035             


Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
    1040                 1045                 1050             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1055                 1060                 1065             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1070                 1075                 1080             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ala Ala 
    1085                 1090                 1095             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ser Gln 
    1100                 1105                 1110             


Glu Arg  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Glu Gly Lys 
    1115                 1120                 1125             


Ala Tyr  Phe Pro Arg Glu Gly  Val Phe Val Phe Asn  Gly Thr Ser 
    1130                 1135                 1140             


Trp Phe  Ile Thr Gln Arg Asn  Phe Phe Ser Pro Gln  Ile Ile Thr 
    1145                 1150                 1155             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1160                 1165                 1170             


Ile Ile  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1175                 1180                 1185             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1190                 1195                 1200             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1205                 1210                 1215             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1220                 1225                 1230             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1235                 1240                 1245             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Val Trp Leu  Gly Phe Ile 
    1250                 1255                 1260             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Leu  Leu Cys Cys 
    1265                 1270                 1275             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Ala Cys  Ser Cys Gly 
    1280                 1285                 1290             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1295                 1300                 1305             


Gly Val  Lys Leu His Tyr Thr  
    1310                 1315 


<210>  5
<211>  547
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human Intercellular adhesion molecule 3

<400>  5

Met Ala Thr Met Val Pro Ser Val Leu Trp Pro Arg Ala Cys Trp Thr 
1               5                   10                  15      


Leu Leu Val Cys Cys Leu Leu Thr Pro Gly Val Gln Gly Gln Glu Phe 
            20                  25                  30          


Leu Leu Arg Val Glu Pro Gln Asn Pro Val Leu Ser Ala Gly Gly Ser 
        35                  40                  45              


Leu Phe Val Asn Cys Ser Thr Asp Cys Pro Ser Ser Glu Lys Ile Ala 
    50                  55                  60                  


Leu Glu Thr Ser Leu Ser Lys Glu Leu Val Ala Ser Gly Met Gly Trp 
65                  70                  75                  80  


Ala Ala Phe Asn Leu Ser Asn Val Thr Gly Asn Ser Arg Ile Leu Cys 
                85                  90                  95      


Ser Val Tyr Cys Asn Gly Ser Gln Ile Thr Gly Ser Ser Asn Ile Thr 
            100                 105                 110         


Val Tyr Arg Leu Pro Glu Arg Val Glu Leu Ala Pro Leu Pro Pro Trp 
        115                 120                 125             


Gln Pro Val Gly Gln Asn Phe Thr Leu Arg Cys Gln Val Glu Asp Gly 
    130                 135                 140                 


Ser Pro Arg Thr Ser Leu Thr Val Val Leu Leu Arg Trp Glu Glu Glu 
145                 150                 155                 160 


Leu Ser Arg Gln Pro Ala Val Glu Glu Pro Ala Glu Val Thr Ala Thr 
                165                 170                 175     


Val Leu Ala Ser Arg Asp Asp His Gly Ala Pro Phe Ser Cys Arg Thr 
            180                 185                 190         


Glu Leu Asp Met Gln Pro Gln Gly Leu Gly Leu Phe Val Asn Thr Ser 
        195                 200                 205             


Ala Pro Arg Gln Leu Arg Thr Phe Val Leu Pro Val Thr Pro Pro Arg 
    210                 215                 220                 


Leu Val Ala Pro Arg Phe Leu Glu Val Glu Thr Ser Trp Pro Val Asp 
225                 230                 235                 240 


Cys Thr Leu Asp Gly Leu Phe Pro Ala Ser Glu Ala Gln Val Tyr Leu 
                245                 250                 255     


Ala Leu Gly Asp Gln Met Leu Asn Ala Thr Val Met Asn His Gly Asp 
            260                 265                 270         


Thr Leu Thr Ala Thr Ala Thr Ala Thr Ala Arg Ala Asp Gln Glu Gly 
        275                 280                 285             


Ala Arg Glu Ile Val Cys Asn Val Thr Leu Gly Gly Glu Arg Arg Glu 
    290                 295                 300                 


Ala Arg Glu Asn Leu Thr Val Phe Ser Phe Leu Gly Pro Ile Val Asn 
305                 310                 315                 320 


Leu Ser Glu Pro Thr Ala His Glu Gly Ser Thr Val Thr Val Ser Cys 
                325                 330                 335     


Met Ala Gly Ala Arg Val Gln Val Thr Leu Asp Gly Val Pro Ala Ala 
            340                 345                 350         


Ala Pro Gly Gln Pro Ala Gln Leu Gln Leu Asn Ala Thr Glu Ser Asp 
        355                 360                 365             


Asp Gly Arg Ser Phe Phe Cys Ser Ala Thr Leu Glu Val Asp Gly Glu 
    370                 375                 380                 


Phe Leu His Arg Asn Ser Ser Val Gln Leu Arg Val Leu Tyr Gly Pro 
385                 390                 395                 400 


Lys Ile Asp Arg Ala Thr Cys Pro Gln His Leu Lys Trp Lys Asp Lys 
                405                 410                 415     


Thr Arg His Val Leu Gln Cys Gln Ala Arg Gly Asn Pro Tyr Pro Glu 
            420                 425                 430         


Leu Arg Cys Leu Lys Glu Gly Ser Ser Arg Glu Val Pro Val Gly Ile 
        435                 440                 445             


Pro Phe Phe Val Asn Val Thr His Asn Gly Thr Tyr Gln Cys Gln Ala 
    450                 455                 460                 


Ser Ser Ser Arg Gly Lys Tyr Thr Leu Val Val Val Met Asp Ile Glu 
465                 470                 475                 480 


Ala Gly Ser Ser His Phe Val Pro Val Phe Val Ala Val Leu Leu Thr 
                485                 490                 495     


Leu Gly Val Val Thr Ile Val Leu Ala Leu Met Tyr Val Phe Arg Glu 
            500                 505                 510         


His Gln Arg Ser Gly Ser Tyr His Val Arg Glu Glu Ser Thr Tyr Leu 
        515                 520                 525             


Pro Leu Thr Ser Met Gln Pro Thr Glu Ala Met Gly Glu Glu Pro Ser 
    530                 535                 540                 


Arg Ala Glu 
545         


