                         SEQUENCE LISTING

<110>  UNIVERSITY OF MIAMI
       DE RIVERO VACCARI, JUAN PABLO
       KEANE, ROBERT W.
       DIETRICH, W. DALTON

<120>  COMPOSITIONS AND METHODS FOR DETECTING AND TREATING 
       INFLAMMASOME-RELATED DISORDERS

<130>  UNMI-015/03WO 316457-2115

<150>  US 63/062,622
<151>  2020-08-07

<150>  US 63/016,033
<151>  2020-04-27

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Ala Leu Arg Gln Thr Gln Pro Tyr Leu Val Thr Asp Leu Glu Gln Ser 
1               5                   10                  15      


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Glu Ser Gln Ser Tyr Leu Val Glu Asp Leu Glu Arg Ser 
1               5                   10                  


<210>  3
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Glu Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg Glu Lys Ser Glu 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  4
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Glu Glu Ser Gln Ser Lys Glu Glu Ser Asn Thr Glu Gly Cys 
1               5                   10                  15  


<210>  5
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  5

Lys Lys Phe Lys Leu Lys Leu Leu Ser Val Pro Leu Arg Glu Gly Tyr 
1               5                   10                  15      


Gly Arg Ile Pro Arg 
            20      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain (H) CDR1

<400>  6

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain (H) CDR2

<400>  7

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain (H) CDR3

<400>  8

Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr 
1               5                   10      


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain( H)  CDR1

<400>  9
actagtggaa tgggtgtgag c                                                 21


<210>  10
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain (H) CDR2

<400>  10
cacatttatt gggatgatga taagcgctac aacccatctc tgaagagc                    48


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain (H) CDR3

<400>  11
agcaccccca tcgtggccaa cgccatggac tac                                    33


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR1

<400>  12

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR2

<400>  13

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR3

<400>  14

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR1

<400>  15
aaggccagcc agagtgttga ctacgacggc gacagttaca tgaat                       45


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR2

<400>  16
gccgcatcta acctggaatc c                                                 21


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) (L) Chain CDR3

<400>  17
cagcaatcta atgaggaccc ttacact                                           27


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 1 Chain

<400>  18

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Ile Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 2 Chain

<400>  19

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 3 Chain

<400>  20

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 4 Chain

<400>  21

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) Chimeric (O) Chain

<400>  22

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 1 Chain

<400>  23
caggtcacct tgaaggagtc tggtcctgcc atcgtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagccctcag gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttaaaa tcaccagcgt ggaccctgtg gacacagcca catattcctg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccagcgt caccgtctcc      360

tca                                                                    363


<210>  24
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 2 Chain

<400>  24
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattcctg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  25
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 3 Chain

<400>  25
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  26
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) 4 Chain

<400>  26
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  27
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Heavy (VH) Chimeric (O) Chain

<400>  27
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tataacccat ccctgaagag ccggctcaca atctccaagg attcctccag caaccaggtc      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactcctg tgctcgaagt      300

actccgattg tagctaatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 1 Chain

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Glu Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 2 Chain

<400>  29

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 3 Chain

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) Chimeric (O) Chain

<400>  31

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 1 Chain

<400>  32
gacatcgtgc tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg aggaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  33
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 2 Chain

<400>  33
gacatcgtgc tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagc ctgaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  34
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light (VL) 3 Chain

<400>  34
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagc ctgaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  35
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variable Kappa Light  (VL) Chimeric (O) Chain

<400>  35
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

ggcatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggacccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


<210>  36
<211>  753
<212>  PRT
<213>  Homo sapiens

<400>  36

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Glu 
            260                 265                 270         


Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
        275                 280                 285             


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
    290                 295                 300                 


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
305                 310                 315                 320 


Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr Thr 
                325                 330                 335     


Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala Ala 
            340                 345                 350         


Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu 
        355                 360                 365             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    370                 375                 380                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
385                 390                 395                 400 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                405                 410                 415     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            420                 425                 430         


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
        435                 440                 445             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
    450                 455                 460                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
465                 470                 475                 480 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu 
                485                 490                 495     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            500                 505                 510         


Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        515                 520                 525             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    530                 535                 540                 


Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu 
545                 550                 555                 560 


Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu 
                565                 570                 575     


Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val 
            580                 585                 590         


Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly 
        595                 600                 605             


Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp 
    610                 615                 620                 


Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly 
625                 630                 635                 640 


Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala 
                645                 650                 655     


Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 
            660                 665                 670         


Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 
        675                 680                 685             


Met Val Gly Gly Val Val Ile Ala Thr Val Ile Val Ile Thr Leu Val 
    690                 695                 700                 


Met Leu Lys Lys Lys Gln Tyr Thr Ser Ile His His Gly Val Val Glu 
705                 710                 715                 720 


Val Asp Ala Ala Val Thr Pro Glu Glu Arg His Leu Ser Lys Met Gln 
                725                 730                 735     


Gln Asn Gly Tyr Glu Asn Pro Thr Tyr Lys Phe Phe Glu Gln Met Gln 
            740                 745                 750         


Asn 
    


<210>  37
<211>  670
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Glu 
            260                 265                 270         


Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
        275                 280                 285             


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
    290                 295                 300                 


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
305                 310                 315                 320 


Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr Thr 
                325                 330                 335     


Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala Ala 
            340                 345                 350         


Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu 
        355                 360                 365             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    370                 375                 380                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
385                 390                 395                 400 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                405                 410                 415     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            420                 425                 430         


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
        435                 440                 445             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
    450                 455                 460                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
465                 470                 475                 480 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu 
                485                 490                 495     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            500                 505                 510         


Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        515                 520                 525             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    530                 535                 540                 


Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu 
545                 550                 555                 560 


Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu 
                565                 570                 575     


Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val 
            580                 585                 590         


Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly 
        595                 600                 605             


Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp 
    610                 615                 620                 


Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly 
625                 630                 635                 640 


Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met Asp Ala 
                645                 650                 655     


Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
            660                 665                 670 


<210>  38
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  38

Leu Glu Val Pro Thr Asp Gly Asn Ala Gly Leu Leu Ala Glu Pro Gln 
1               5                   10                  15      


Ile Ala Met Phe Cys Gly Arg Leu Asn Met His Met Asn Val Gln Asn 
            20                  25                  30          


Gly Lys Trp Asp Ser Asp Pro Ser Gly Thr Lys Thr Cys Ile Asp Thr 
        35                  40                  45              


Lys Glu Gly Ile Leu Gln Tyr Cys Gln Glu Val Tyr Pro Glu Leu Gln 
    50                  55                  60                  


Ile Thr Asn Val Val Glu Ala Asn Gln Pro Val Thr Ile Gln Asn Trp 
65                  70                  75                  80  


Cys Lys Arg Gly Arg Lys Gln Cys Lys Thr His Pro His Phe Val Ile 
                85                  90                  95      


Pro Tyr Arg Cys Leu Val Gly Glu Phe Val Ser Asp Ala Leu Leu Val 
            100                 105                 110         


Pro Asp Lys Cys Lys Phe Leu His Gln Glu Arg Met Asp Val Cys Glu 
        115                 120                 125             


Thr His Leu His Trp His Thr Val Ala Lys Glu Thr Cys Ser Glu Lys 
    130                 135                 140                 


Ser Thr Asn Leu His Asp Tyr Gly Met Leu Leu Pro Cys Gly Ile Asp 
145                 150                 155                 160 


Lys Phe Arg Gly Val Glu Phe Val Cys Cys Pro Leu Ala Glu Glu Ser 
                165                 170                 175     


Asp Asn Val Asp Ser Ala Asp Ala Glu Glu Asp Asp Ser Asp Val Trp 
            180                 185                 190         


Trp Gly Gly Ala Asp Thr Asp Tyr Ala Asp Gly Ser Glu Asp Lys Val 
        195                 200                 205             


Val Glu Val Ala Glu Glu Glu Glu Val Ala Glu Val Glu Glu Glu Glu 
    210                 215                 220                 


Ala Asp Asp Asp Glu Asp Asp Glu Asp Gly Asp Glu Val Glu Glu Glu 
225                 230                 235                 240 


Ala Glu Glu Pro Tyr Glu Glu Ala Thr Glu Arg Thr Thr Ser Ile Ala 
                245                 250                 255     


Thr Thr Thr Thr Thr Thr Thr Glu Ser Val Glu Glu Val Val Arg Glu 
            260                 265                 270         


Val Cys Ser Glu Gln Ala Glu Thr Gly Pro Cys Arg Ala Met Ile Ser 
        275                 280                 285             


Arg Trp Tyr Phe Asp Val Thr Glu Gly Lys Cys Ala Pro Phe Phe Tyr 
    290                 295                 300                 


Gly Gly Cys Gly Gly Asn Arg Asn Asn Phe Asp Thr Glu Glu Tyr Cys 
305                 310                 315                 320 


Met Ala Val Cys Gly Ser Ala Met Ser Gln Ser Leu Leu Lys Thr Thr 
                325                 330                 335     


Gln Glu Pro Leu Ala Arg Asp Pro Val Lys Leu Pro Thr Thr Ala Ala 
            340                 345                 350         


Ser Thr Pro Asp Ala Val Asp Lys Tyr Leu Glu Thr Pro Gly Asp Glu 
        355                 360                 365             


Asn Glu His Ala His Phe Gln Lys Ala Lys Glu Arg Leu Glu Ala Lys 
    370                 375                 380                 


His Arg Glu Arg Met Ser Gln Val Met Arg Glu Trp Glu Glu Ala Glu 
385                 390                 395                 400 


Arg Gln Ala Lys Asn Leu Pro Lys Ala Asp Lys Lys Ala Val Ile Gln 
                405                 410                 415     


His Phe Gln Glu Lys Val Glu Ser Leu Glu Gln Glu Ala Ala Asn Glu 
            420                 425                 430         


Arg Gln Gln Leu Val Glu Thr His Met Ala Arg Val Glu Ala Met Leu 
        435                 440                 445             


Asn Asp Arg Arg Arg Leu Ala Leu Glu Asn Tyr Ile Thr Ala Leu Gln 
    450                 455                 460                 


Ala Val Pro Pro Arg Pro Arg His Val Phe Asn Met Leu Lys Lys Tyr 
465                 470                 475                 480 


Val Arg Ala Glu Gln Lys Asp Arg Gln His Thr Leu Lys His Phe Glu 
                485                 490                 495     


His Val Arg Met Val Asp Pro Lys Lys Ala Ala Gln Ile Arg Ser Gln 
            500                 505                 510         


Val Met Thr His Leu Arg Val Ile Tyr Glu Arg Met Asn Gln Ser Leu 
        515                 520                 525             


Ser Leu Leu Tyr Asn Val Pro Ala Val Ala Glu Glu Ile Gln Asp Glu 
    530                 535                 540                 


Val Asp Glu Leu Leu Gln Lys Glu Gln Asn Tyr Ser Asp Asp Val Leu 
545                 550                 555                 560 


Ala Asn Met Ile Ser Glu Pro Arg Ile Ser Tyr Gly Asn Asp Ala Leu 
                565                 570                 575     


Met Pro Ser Leu Thr Glu Thr Lys Thr Thr Val Glu Leu Leu Pro Val 
            580                 585                 590         


Asn Gly Glu Phe Ser Leu Asp Asp Leu Gln Pro Trp His Ser Phe Gly 
        595                 600                 605             


Ala Asp Ser Val Pro Ala Asn Thr Glu Asn Glu Val Glu Pro Val Asp 
    610                 615                 620                 


Ala Arg Pro Ala Ala Asp Arg Gly Leu Thr Thr Arg Pro Gly Ser Gly 
625                 630                 635                 640 


Leu Thr Asn Ile Lys Thr Glu Glu Ile Ser Glu Val Lys Met 
                645                 650                 


<210>  39
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  39

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val Ile Ala 
        35                  40          


<210>  40
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 
1               5                   10                  15      


Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 
            20                  25                  30          


Gly Leu Met Val Gly Gly Val Val 
        35                  40  


<210>  41
<211>  542
<212>  PRT
<213>  Homo sapiens

<400>  41

Ser Ser Phe Ser Tyr Glu Pro Tyr Tyr Ser Thr Ser Tyr Lys Arg Arg 
1               5                   10                  15      


Tyr Val Glu Thr Pro Arg Val His Ile Ser Ser Val Arg Ser Gly Tyr 
            20                  25                  30          


Ser Thr Ala Arg Ser Ala Tyr Ser Ser Tyr Ser Ala Pro Val Ser Ser 
        35                  40                  45              


Ser Leu Ser Val Arg Arg Ser Tyr Ser Ser Ser Ser Gly Ser Leu Met 
    50                  55                  60                  


Pro Ser Leu Glu Asn Leu Asp Leu Ser Gln Val Ala Ala Ile Ser Asn 
65                  70                  75                  80  


Asp Leu Lys Ser Ile Arg Thr Gln Glu Lys Ala Gln Leu Gln Asp Leu 
                85                  90                  95      


Asn Asp Arg Phe Ala Ser Phe Ile Glu Arg Val His Glu Leu Glu Gln 
            100                 105                 110         


Gln Asn Lys Val Leu Glu Ala Glu Leu Leu Val Leu Arg Gln Lys His 
        115                 120                 125             


Ser Glu Pro Ser Arg Phe Arg Ala Leu Tyr Glu Gln Glu Ile Arg Asp 
    130                 135                 140                 


Leu Arg Leu Ala Ala Glu Asp Ala Thr Asn Glu Lys Gln Ala Leu Gln 
145                 150                 155                 160 


Gly Glu Arg Glu Gly Leu Glu Glu Thr Leu Arg Asn Leu Gln Ala Arg 
                165                 170                 175     


Tyr Glu Glu Glu Val Leu Ser Arg Glu Asp Ala Glu Gly Arg Leu Met 
            180                 185                 190         


Glu Ala Arg Lys Gly Ala Asp Glu Ala Ala Leu Ala Arg Ala Glu Leu 
        195                 200                 205             


Glu Lys Arg Ile Asp Ser Leu Met Asp Glu Ile Ser Phe Leu Lys Lys 
    210                 215                 220                 


Val His Glu Glu Glu Ile Ala Glu Leu Gln Ala Gln Ile Gln Tyr Ala 
225                 230                 235                 240 


Gln Ile Ser Val Glu Met Asp Val Thr Lys Pro Asp Leu Ser Ala Ala 
                245                 250                 255     


Leu Lys Asp Ile Arg Ala Gln Tyr Glu Lys Leu Ala Ala Lys Asn Met 
            260                 265                 270         


Gln Asn Ala Glu Glu Trp Phe Lys Ser Arg Phe Thr Val Leu Thr Glu 
        275                 280                 285             


Ser Ala Ala Lys Asn Thr Asp Ala Val Arg Ala Ala Lys Asp Glu Val 
    290                 295                 300                 


Ser Glu Ser Arg Arg Leu Leu Lys Ala Lys Thr Leu Glu Ile Glu Ala 
305                 310                 315                 320 


Cys Arg Gly Met Asn Glu Ala Leu Glu Lys Gln Leu Gln Glu Leu Glu 
                325                 330                 335     


Asp Lys Gln Asn Ala Asp Ile Ser Ala Met Gln Asp Thr Ile Asn Lys 
            340                 345                 350         


Leu Glu Asn Glu Leu Arg Thr Thr Lys Ser Glu Met Ala Arg Tyr Leu 
        355                 360                 365             


Lys Glu Tyr Gln Asp Leu Leu Asn Val Lys Met Ala Leu Asp Ile Glu 
    370                 375                 380                 


Ile Ala Ala Tyr Arg Lys Leu Leu Glu Gly Glu Glu Thr Arg Leu Ser 
385                 390                 395                 400 


Phe Thr Ser Val Gly Ser Ile Thr Ser Gly Tyr Ser Gln Ser Ser Gln 
                405                 410                 415     


Val Phe Gly Arg Ser Ala Tyr Gly Gly Leu Gln Thr Ser Ser Tyr Leu 
            420                 425                 430         


Met Ser Thr Arg Ser Phe Pro Ser Tyr Tyr Thr Ser His Val Gln Glu 
        435                 440                 445             


Glu Gln Ile Glu Val Glu Glu Thr Ile Glu Ala Ala Lys Ala Glu Glu 
    450                 455                 460                 


Ala Lys Asp Glu Pro Pro Ser Glu Gly Glu Ala Glu Glu Glu Glu Lys 
465                 470                 475                 480 


Asp Lys Glu Glu Ala Glu Glu Glu Glu Ala Ala Glu Glu Glu Glu Ala 
                485                 490                 495     


Ala Lys Glu Glu Ser Glu Glu Ala Lys Glu Glu Glu Glu Gly Gly Glu 
            500                 505                 510         


Gly Glu Glu Gly Glu Glu Thr Lys Glu Ala Glu Glu Glu Glu Lys Lys 
        515                 520                 525             


Val Glu Gly Ala Gly Glu Glu Gln Ala Ala Lys Lys Lys Asp 
    530                 535                 540         


