                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
 
<120>  COMPOSITIONS AND METHODS FOR REDUCING NUCLEASE EXPRESSION AND 
       OFF-TARGET ACTIVITY USING A PROMOTER WITH LOW TRANSCRIPTIONAL 
       ACTIVITY

<130>  UPN-20-9267PCT

<150>  US 63/016,139
<151>  2020-04-27

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRE motif

<400>  1

Leu Ala Gly Leu Ile Asp Ala Asp Gly 
1               5                   


<210>  2
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CRE Recognition sequence

<400>  2
caaaacgtcg tgagacagtt tg                                                22


<210>  3
<211>  978
<212>  DNA
<213>  Homo sapiens

<400>  3
acctgaagag agaggaagct gtgggacagg tccagccaga gcccaggcca gaggggcaga       60

agctggagtc ctggagcaca gacgcaggtt gtcaggtgca cagagttgga gggtcccctg      120

ctggtcatgg ttggccatgg gggcacccag gagggatcag cgagctggct acacctaaaa      180

atcagtccaa agtccgaggt ccaaagagat aaataaaaac attgacaaat aagtcaaacg      240

gtccagcaac aaatggggac ccaaggatca ggcacattgt tttttttttt tttggagtat      300

tagcatacac tgtgacatga aagagtgtga gctcaatcat gtggccttgg actgggagag      360

ggcatttcct tctcagaggc aactaagccc tacctttgcc tcagtctggg ctctgtaatc      420

ctgctttgtg ctcatctccc caagactgat cacctggggg aagctggggt ggttcaaccc      480

tgcctgccct tccccaacat acagatggtg gcaggtaaca tggtgaaatc aaacagatct      540

ggtttttcat ccgcctatcc acccaggtga ccttggacaa tttatttagc ctctaggcct      600

cagtagtccc agggaagtaa taatcgctac ttcactattt taaggattat ataagatagg      660

gcatgtaagg tagctgacac acattcgccc atttcttcac gtgaattcag attctactga      720

attcagctct gcaccaagtc ccatcctctg ctgccctctg tttcagcaaa cactgaggcc      780

tgttgtttct cctcctctac cggctctgat gcggtcaagg tccagagagc tgagtagttg      840

gcaagcggac caccagcaac agacaacatc ttcattcggc tctccctgaa gctgtactgc      900

ctcgctgaga ggatgaaggt ctccgaggct gccctgtctc tccttgtcct catccttatc      960

attacttcgg cttctcgc                                                    978


<210>  4
<211>  919
<212>  DNA
<213>  Homo sapiens

<400>  4
tttgcctcca attcttccac agcacatagt gcatctcaca taatatttat aatgttggag       60

tgcaattgtt tatgtactct ctcttactta ctcaactata agatccttga acttgtcaca      120

cacgttactt taggaactag catggaaaag gtcttcacaa atactatctg aaaaatcaat      180

aagccagtaa aagtaaacct ccatatgagc ttactcctct gcttttcatc accatctatt      240

ctgtccacat ttcaagcaat gtatttccag catgaatttg tggtgtgatt tgacatgaag      300

gagaacatca gtcaccaaaa tgaaaggatt gtaccacagt acccttattt tagtttaact      360

tcgacttttt tagattaact cttaatcaaa aattggtact taacaaggaa aaacttgcct      420

tctgttgttt tcagagaagt aaaaaaagca cctcaccttt gagtcgccaa aattatgctt      480

cctggaatga ccgcatacca tgtagcaggt ttattttagt ttgtttacag aaaagtgtag      540

accaaagtcc agtgctgact ttgggagcta ctaaagacat gaaaaagtag aattttaaac      600

acatttcatt gtaaacgact gggagtatct gagcaaatta tttcttacgt gactttagag      660

aaaacggcta cctatctgac cccaaaacga cttgaggaaa ctgtttccac ggtcctgctg      720

cagaggggaa gcacagtcgt caagaagaga gtggggtcag gatcaaaaca catttagtgt      780

gacttaggga aagaaaacat tttccctctt tgaacctctc tggatacagt cattttgcct      840

ctacttgagg atcaactgtt caacctcaat ggcctttcag gacctcctgg gtcacgctgg      900

tgacctgtgg agattccag                                                   919


<210>  5
<211>  799
<212>  DNA
<213>  Homo sapiens

<400>  5
ttggatctca gagacgggca ccgactgccg agccccagac gaagtgcccc agggtcgggg       60

atcaggcttg tgcagggtag cacctgggga cctgagggac ctggaggcct tcttgtatcc      120

tgaagtagga ccttctaaga cttcatgagt cctggccccc ttgcaggggt tggggagctg      180

gggatcccag atctgcctat tgcgcccgat gccccgaggc tctctcttgg actctggccc      240

tgagttcttc tgcgcgatcc ttcggagacg tctggaggcc tgctttatgc atctctcttg      300

gacctcagtt tccccacacg tgggaggagg cagctggacg attcctgaaa ggactttccc      360

ttgcttcctc atcacgtgga agagagccca cccggcacct ggaaatggaa agccagtgaa      420

ggctgctttg ggccggggca gcgggtggga ccgggcggga gggattccaa agagaccgcc      480

gggaaggcta gagcttggaa ttccggctcc tcggagtcct ggccctcccc caccgccgcc      540

tcggagctca gcacaccttg gatgggggag gcaggcagct cctagccccg caccccagga      600

ggcgcgctcg gagggaagcc gccaccgcgc cgcctctgcc tcggcgcgga acaaacggtt      660

aaagattttg ggcagcgcct cgcgggggga ggagccaggg gcccaatccg caattaaaga      720

tgaactttgg gtgaactaat tgtctgacca aggtaacgtg ggcagcaacc tgggccgcct      780

ataaagcggc agcgccgtg                                                   799


<210>  6
<211>  64
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  6
gagtgctcta gttttgcaat acaggacatg ctataaaaat ggaaagatgt tgctttctga       60

gaga                                                                    64


<210>  7
<211>  113
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  7
ctttgaaaat accatcccag ggttaatgct ggggttaatt tataactaag agtgctctag       60

ttttgcaata caggacatgc tataaaaatg gaaagatgtt gctttctgag aga             113


<210>  8
<211>  140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  8
cctcttggcc ttggttttgt acatcagctt tgaaaatacc atcccagggt taatgctggg       60

gttaatttat aactaagagt gctctagttt tgcaatacag gacatgctat aaaaatggaa      120

agatgttgct ttctgagaga                                                  140


<210>  9
<211>  2729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(1183)
<223>  CCL16 promoter

<220>
<221>  misc_feature
<222>  (1193)..(2287)
<223>  PCS7-8L.197 CDS

<220>
<221>  misc_feature
<222>  (2298)..(2512)
<223>  PolyA

<220>
<221>  misc_feature
<222>  (2562)..(2729)
<223>  ITR

<400>  9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagacctg aagagagagg aagctgtggg acaggtccag      240

ccagagccca ggccagaggg gcagaagctg gagtcctgga gcacagacgc aggttgtcag      300

gtgcacagag ttggagggtc ccctgctggt catggttggc catgggggca cccaggaggg      360

atcagcgagc tggctacacc taaaaatcag tccaaagtcc gaggtccaaa gagataaata      420

aaaacattga caaataagtc aaacggtcca gcaacaaatg gggacccaag gatcaggcac      480

attgtttttt ttttttttgg agtattagca tacactgtga catgaaagag tgtgagctca      540

atcatgtggc cttggactgg gagagggcat ttccttctca gaggcaacta agccctacct      600

ttgcctcagt ctgggctctg taatcctgct ttgtgctcat ctccccaaga ctgatcacct      660

gggggaagct ggggtggttc aaccctgcct gcccttcccc aacatacaga tggtggcagg      720

taacatggtg aaatcaaaca gatctggttt ttcatccgcc tatccaccca ggtgaccttg      780

gacaatttat ttagcctcta ggcctcagta gtcccaggga agtaataatc gctacttcac      840

tattttaagg attatataag atagggcatg taaggtagct gacacacatt cgcccatttc      900

ttcacgtgaa ttcagattct actgaattca gctctgcacc aagtcccatc ctctgctgcc      960

ctctgtttca gcaaacactg aggcctgttg tttctcctcc tctaccggct ctgatgcggt     1020

caaggtccag agagctgagt agttggcaag cggaccacca gcaacagaca acatcttcat     1080

tcggctctcc ctgaagctgt actgcctcgc tgagaggatg aaggtctccg aggctgccct     1140

gtctctcctt gtcctcatcc ttatcattac ttcggcttct cgcgcggccg ccatggcacc     1200

gaagaagaag cgcaaggtgc atatgaatac aaaatataat aaagagttct tactctactt     1260

agcagggttt gtagacggtg acggttccat ctttgccagg atcaagccta gtcaacgtag     1320

taagttcaag cacaagctgc atctcgtttt cgctgtctat cagaagacac agcgccgttg     1380

gttcctcgac aagctggtgg acgagatcgg tgtgggttac gtgctggact ctggcagcgt     1440

ctccttttac tcgctgtccg agatcaagcc tttgcataat tttttaacac aactacaacc     1500

ttttctaaaa ctaaaacaaa aacaagcaaa tttagtttta aaaattattg aacaacttcc     1560

gtcagcaaaa gaatccccgg acaaattctt agaagtttgt acatgggtgg atcaaattgc     1620

agctctgaat gattcgaaga cgcgtaaaac aacttctgaa accgttcgtg ctgtgctaga     1680

cagtttacca ggatccgtgg gaggtctatc gccatctcag gcatccagcg ccgcatcctc     1740

ggcttcctca agcccgggtt cagggatctc cgaagcactc agagctggag caggttccgg     1800

cactggatac aacaaggaat tcctgctcta cctggcgggc ttcgtcgacg gggacggctc     1860

catctatgcc cgtatcaagc cggttcagcg ggctaagttc aagcacgagc tggttctcgg     1920

gttcgatgtc actcagaaga cacagcgccg ttggttcctc gacaagctgg tggacgagat     1980

cggtgtgggt tacgtgtatg acaagggcag cgtctccgcg taccgtctgt cccagatcaa     2040

gcctctgcac aacttcctga cccagctcca gcccttcctg aagctcaagc agaagcaggc     2100

caacctcgtg ctgaagatca tcgagcagct gccctccgcc aaggaatccc cggacaagtt     2160

cctggaggtg tgcacctggg tggaccagat cgccgctctg aacgactcca agacccgcaa     2220

gaccacttcc gaaaccgtcc gcgccgttct agacagtctc tccgagaaga agaagtcgtc     2280

cccctaaggt acgatctgcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc     2340

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     2400

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     2460

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gactcgagtt     2520

aagggcgaat tcccgataag gatcttccta gagcatggct acgtagataa gtagcatggc     2580

gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc     2640

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     2700

gcggcctcag tgagcgagcg agcgcgcag                                       2729


<210>  10
<211>  2669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(1124)
<223>  SLC22A9 promoter

<220>
<221>  misc_feature
<222>  (1133)..(2227)
<223>  PCS7-8L CDS

<220>
<221>  misc_feature
<222>  (2238)..(2452)
<223>  BGH Poly A

<220>
<221>  misc_feature
<222>  (2502)..(2669)
<223>  ITR

<400>  10
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagtttgc ctccaattct tccacagcac atagtgcatc      240

tcacataata tttataatgt tggagtgcaa ttgtttatgt actctctctt acttactcaa      300

ctataagatc cttgaacttg tcacacacgt tactttagga actagcatgg aaaaggtctt      360

cacaaatact atctgaaaaa tcaataagcc agtaaaagta aacctccata tgagcttact      420

cctctgcttt tcatcaccat ctattctgtc cacatttcaa gcaatgtatt tccagcatga      480

atttgtggtg tgatttgaca tgaaggagaa catcagtcac caaaatgaaa ggattgtacc      540

acagtaccct tattttagtt taacttcgac ttttttagat taactcttaa tcaaaaattg      600

gtacttaaca aggaaaaact tgccttctgt tgttttcaga gaagtaaaaa aagcacctca      660

cctttgagtc gccaaaatta tgcttcctgg aatgaccgca taccatgtag caggtttatt      720

ttagtttgtt tacagaaaag tgtagaccaa agtccagtgc tgactttggg agctactaaa      780

gacatgaaaa agtagaattt taaacacatt tcattgtaaa cgactgggag tatctgagca      840

aattatttct tacgtgactt tagagaaaac ggctacctat ctgaccccaa aacgacttga      900

ggaaactgtt tccacggtcc tgctgcagag gggaagcaca gtcgtcaaga agagagtggg      960

gtcaggatca aaacacattt agtgtgactt agggaaagaa aacattttcc ctctttgaac     1020

ctctctggat acagtcattt tgcctctact tgaggatcaa ctgttcaacc tcaatggcct     1080

ttcaggacct cctgggtcac gctggtgacc tgtggagatt ccagcggccg ccatggcacc     1140

gaagaagaag cgcaaggtgc atatgaatac aaaatataat aaagagttct tactctactt     1200

agcagggttt gtagacggtg acggttccat ctttgccagg atcaagccta gtcaacgtag     1260

taagttcaag cacaagctgc atctcgtttt cgctgtctat cagaagacac agcgccgttg     1320

gttcctcgac aagctggtgg acgagatcgg tgtgggttac gtgctggact ctggcagcgt     1380

ctccttttac tcgctgtccg agatcaagcc tttgcataat tttttaacac aactacaacc     1440

ttttctaaaa ctaaaacaaa aacaagcaaa tttagtttta aaaattattg aacaacttcc     1500

gtcagcaaaa gaatccccgg acaaattctt agaagtttgt acatgggtgg atcaaattgc     1560

agctctgaat gattcgaaga cgcgtaaaac aacttctgaa accgttcgtg ctgtgctaga     1620

cagtttacca ggatccgtgg gaggtctatc gccatctcag gcatccagcg ccgcatcctc     1680

ggcttcctca agcccgggtt cagggatctc cgaagcactc agagctggag caggttccgg     1740

cactggatac aacaaggaat tcctgctcta cctggcgggc ttcgtcgacg gggacggctc     1800

catctatgcc cgtatcaagc cggttcagcg ggctaagttc aagcacgagc tggttctcgg     1860

gttcgatgtc actcagaaga cacagcgccg ttggttcctc gacaagctgg tggacgagat     1920

cggtgtgggt tacgtgtatg acaagggcag cgtctccgcg taccgtctgt cccagatcaa     1980

gcctctgcac aacttcctga cccagctcca gcccttcctg aagctcaagc agaagcaggc     2040

caacctcgtg ctgaagatca tcgagcagct gccctccgcc aaggaatccc cggacaagtt     2100

cctggaggtg tgcacctggg tggaccagat cgccgctctg aacgactcca agacccgcaa     2160

gaccacttcc gaaaccgtcc gcgccgttct agacagtctc tccgagaaga agaagtcgtc     2220

cccctaaggt acgatctgcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc     2280

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     2340

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     2400

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gactcgagtt     2460

aagggcgaat tcccgataag gatcttccta gagcatggct acgtagataa gtagcatggc     2520

gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc     2580

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     2640

gcggcctcag tgagcgagcg agcgcgcag                                       2669


<210>  11
<211>  2549
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(1004)
<223>  CYP26A1 - 1K promoter

<220>
<221>  misc_feature
<222>  (1013)..(2107)
<223>  PCS7-8L CDS

<220>
<221>  misc_feature
<222>  (2118)..(2332)
<223>  bGH Poly A

<220>
<221>  misc_feature
<222>  (2382)..(2549)
<223>  ITR

<400>  11
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagttgga tctcagagac gggcaccgac tgccgagccc      240

cagacgaagt gccccagggt cggggatcag gcttgtgcag ggtagcacct ggggacctga      300

gggacctgga ggccttcttg tatcctgaag taggaccttc taagacttca tgagtcctgg      360

cccccttgca ggggttgggg agctggggat cccagatctg cctattgcgc ccgatgcccc      420

gaggctctct cttggactct ggccctgagt tcttctgcgc gatccttcgg agacgtctgg      480

aggcctgctt tatgcatctc tcttggacct cagtttcccc acacgtggga ggaggcagct      540

ggacgattcc tgaaaggact ttcccttgct tcctcatcac gtggaagaga gcccacccgg      600

cacctggaaa tggaaagcca gtgaaggctg ctttgggccg gggcagcggg tgggaccggg      660

cgggagggat tccaaagaga ccgccgggaa ggctagagct tggaattccg gctcctcgga      720

gtcctggccc tcccccaccg ccgcctcgga gctcagcaca ccttggatgg gggaggcagg      780

cagctcctag ccccgcaccc caggaggcgc gctcggaggg aagccgccac cgcgccgcct      840

ctgcctcggc gcggaacaaa cggttaaaga ttttgggcag cgcctcgcgg ggggaggagc      900

caggggccca atccgcaatt aaagatgaac tttgggtgaa ctaattgtct gaccaaggta      960

acgtgggcag caacctgggc cgcctataaa gcggcagcgc cgtgcggccg ccatggcacc     1020

gaagaagaag cgcaaggtgc atatgaatac aaaatataat aaagagttct tactctactt     1080

agcagggttt gtagacggtg acggttccat ctttgccagg atcaagccta gtcaacgtag     1140

taagttcaag cacaagctgc atctcgtttt cgctgtctat cagaagacac agcgccgttg     1200

gttcctcgac aagctggtgg acgagatcgg tgtgggttac gtgctggact ctggcagcgt     1260

ctccttttac tcgctgtccg agatcaagcc tttgcataat tttttaacac aactacaacc     1320

ttttctaaaa ctaaaacaaa aacaagcaaa tttagtttta aaaattattg aacaacttcc     1380

gtcagcaaaa gaatccccgg acaaattctt agaagtttgt acatgggtgg atcaaattgc     1440

agctctgaat gattcgaaga cgcgtaaaac aacttctgaa accgttcgtg ctgtgctaga     1500

cagtttacca ggatccgtgg gaggtctatc gccatctcag gcatccagcg ccgcatcctc     1560

ggcttcctca agcccgggtt cagggatctc cgaagcactc agagctggag caggttccgg     1620

cactggatac aacaaggaat tcctgctcta cctggcgggc ttcgtcgacg gggacggctc     1680

catctatgcc cgtatcaagc cggttcagcg ggctaagttc aagcacgagc tggttctcgg     1740

gttcgatgtc actcagaaga cacagcgccg ttggttcctc gacaagctgg tggacgagat     1800

cggtgtgggt tacgtgtatg acaagggcag cgtctccgcg taccgtctgt cccagatcaa     1860

gcctctgcac aacttcctga cccagctcca gcccttcctg aagctcaagc agaagcaggc     1920

caacctcgtg ctgaagatca tcgagcagct gccctccgcc aaggaatccc cggacaagtt     1980

cctggaggtg tgcacctggg tggaccagat cgccgctctg aacgactcca agacccgcaa     2040

gaccacttcc gaaaccgtcc gcgccgttct agacagtctc tccgagaaga agaagtcgtc     2100

cccctaaggt acgatctgcc tcgactgtgc cttctagttg ccagccatct gttgtttgcc     2160

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     2220

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     2280

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gactcgagtt     2340

aagggcgaat tcccgataag gatcttccta gagcatggct acgtagataa gtagcatggc     2400

gggttaatca ttaactacaa ggaaccccta gtgatggagt tggccactcc ctctctgcgc     2460

gctcgctcgc tcactgaggc cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg     2520

gcggcctcag tgagcgagcg agcgcgcag                                       2549


<210>  12
<211>  1817
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(269)
<223>  TBG-S1-F64 promoter

<220>
<221>  misc_feature
<222>  (281)..(1375)
<223>  PCS7-8 CDS

<220>
<221>  misc_feature
<222>  (1386)..(1600)
<223>  bGH Poly A

<220>
<221>  misc_feature
<222>  (1650)..(1817)
<223>  ITR

<400>  12
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaaggagtg ctctagtttt gcaatacagg acatgctata      240

aaaatggaaa gatgttgctt tctgagagac agcggccgcc atggcaccga agaagaagcg      300

caaggtgcat atgaatacaa aatataataa agagttctta ctctacttag cagggtttgt      360

agacggtgac ggttccatct ttgccaggat caagcctagt caacgtagta agttcaagca      420

caagctgcat ctcgttttcg ctgtctatca gaagacacag cgccgttggt tcctcgacaa      480

gctggtggac gagatcggtg tgggttacgt gctggactct ggcagcgtct ccttttactc      540

gctgtccgag atcaagcctt tgcataattt tttaacacaa ctacaacctt ttctaaaact      600

aaaacaaaaa caagcaaatt tagttttaaa aattattgaa caacttccgt cagcaaaaga      660

atccccggac aaattcttag aagtttgtac atgggtggat caaattgcag ctctgaatga      720

ttcgaagacg cgtaaaacaa cttctgaaac cgttcgtgct gtgctagaca gtttaccagg      780

atccgtggga ggtctatcgc catctcaggc atccagcgcc gcatcctcgg cttcctcaag      840

cccgggttca gggatctccg aagcactcag agctggagca ggttccggca ctggatacaa      900

caaggaattc ctgctctacc tggcgggctt cgtcgacggg gacggctcca tctatgcccg      960

tatcaagccg gttcagcggg ctaagttcaa gcacgagctg gttctcgggt tcgatgtcac     1020

tcagaagaca cagcgccgtt ggttcctcga caagctggtg gacgagatcg gtgtgggtta     1080

cgtgtatgac aagggcagcg tctccgcgta ccgtctgtcc cagatcaagc ctctgcacaa     1140

cttcctgacc cagctccagc ccttcctgaa gctcaagcag aagcaggcca acctcgtgct     1200

gaagatcatc gagcagctgc cctccgccaa ggaatccccg gacaagttcc tggaggtgtg     1260

cacctgggtg gaccagatcg ccgctctgaa cgactccaag acccgcaaga ccacttccga     1320

aaccgtccgc gccgttctag acagtctctc cgagaagaag aagtcgtccc cctaaggtac     1380

gatctgcctc gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc     1440

cttccttgac cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg     1500

catcgcattg tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca     1560

agggggagga ttgggaagac aatagcaggc atgctgggga ctcgagttaa gggcgaattc     1620

ccgataagga tcttcctaga gcatggctac gtagataagt agcatggcgg gttaatcatt     1680

aactacaagg aacccctagt gatggagttg gccactccct ctctgcgcgc tcgctcgctc     1740

actgaggccg ggcgaccaaa ggtcgcccga cgcccgggct ttgcccgggc ggcctcagtg     1800

agcgagcgag cgcgcag                                                    1817


<210>  13
<211>  1866
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(318)
<223>  TBG-S1-F113 promoter

<220>
<221>  misc_feature
<222>  (330)..(1424)
<223>  PCS7-8 CDS

<220>
<221>  misc_feature
<222>  (1435)..(1649)
<223>  bGH Poly A

<220>
<221>  misc_feature
<222>  (1699)..(1866)
<223>  ITR

<400>  13
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctttg aaaataccat cccagggtta atgctggggt      240

taatttataa ctaagagtgc tctagttttg caatacagga catgctataa aaatggaaag      300

atgttgcttt ctgagagaca gcggccgcca tggcaccgaa gaagaagcgc aaggtgcata      360

tgaatacaaa atataataaa gagttcttac tctacttagc agggtttgta gacggtgacg      420

gttccatctt tgccaggatc aagcctagtc aacgtagtaa gttcaagcac aagctgcatc      480

tcgttttcgc tgtctatcag aagacacagc gccgttggtt cctcgacaag ctggtggacg      540

agatcggtgt gggttacgtg ctggactctg gcagcgtctc cttttactcg ctgtccgaga      600

tcaagccttt gcataatttt ttaacacaac tacaaccttt tctaaaacta aaacaaaaac      660

aagcaaattt agttttaaaa attattgaac aacttccgtc agcaaaagaa tccccggaca      720

aattcttaga agtttgtaca tgggtggatc aaattgcagc tctgaatgat tcgaagacgc      780

gtaaaacaac ttctgaaacc gttcgtgctg tgctagacag tttaccagga tccgtgggag      840

gtctatcgcc atctcaggca tccagcgccg catcctcggc ttcctcaagc ccgggttcag      900

ggatctccga agcactcaga gctggagcag gttccggcac tggatacaac aaggaattcc      960

tgctctacct ggcgggcttc gtcgacgggg acggctccat ctatgcccgt atcaagccgg     1020

ttcagcgggc taagttcaag cacgagctgg ttctcgggtt cgatgtcact cagaagacac     1080

agcgccgttg gttcctcgac aagctggtgg acgagatcgg tgtgggttac gtgtatgaca     1140

agggcagcgt ctccgcgtac cgtctgtccc agatcaagcc tctgcacaac ttcctgaccc     1200

agctccagcc cttcctgaag ctcaagcaga agcaggccaa cctcgtgctg aagatcatcg     1260

agcagctgcc ctccgccaag gaatccccgg acaagttcct ggaggtgtgc acctgggtgg     1320

accagatcgc cgctctgaac gactccaaga cccgcaagac cacttccgaa accgtccgcg     1380

ccgttctaga cagtctctcc gagaagaaga agtcgtcccc ctaaggtacg atctgcctcg     1440

actgtgcctt ctagttgcca gccatctgtt gtttgcccct cccccgtgcc ttccttgacc     1500

ctggaaggtg ccactcccac tgtcctttcc taataaaatg aggaaattgc atcgcattgt     1560

ctgagtaggt gtcattctat tctggggggt ggggtggggc aggacagcaa gggggaggat     1620

tgggaagaca atagcaggca tgctggggac tcgagttaag ggcgaattcc cgataaggat     1680

cttcctagag catggctacg tagataagta gcatggcggg ttaatcatta actacaagga     1740

acccctagtg atggagttgg ccactccctc tctgcgcgct cgctcgctca ctgaggccgg     1800

gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg gcctcagtga gcgagcgagc     1860

gcgcag                                                                1866


<210>  14
<211>  1893
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence


<220>
<221>  misc_feature
<222>  (1)..(168)
<223>  ITR

<220>
<221>  misc_feature
<222>  (206)..(345)
<223>  TBG-S1-F140

<220>
<221>  misc_feature
<222>  (357)..(1451)
<223>  PCS7-8 CDS

<220>
<221>  misc_feature
<222>  (1462)..(1676)
<223>  bGH PolyA

<220>
<221>  misc_feature
<222>  (1726)..(1893)
<223>  ITR

<400>  14
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagcctct tggccttggt tttgtacatc agctttgaaa      240

ataccatccc agggttaatg ctggggttaa tttataacta agagtgctct agttttgcaa      300

tacaggacat gctataaaaa tggaaagatg ttgctttctg agagacagcg gccgccatgg      360

caccgaagaa gaagcgcaag gtgcatatga atacaaaata taataaagag ttcttactct      420

acttagcagg gtttgtagac ggtgacggtt ccatctttgc caggatcaag cctagtcaac      480

gtagtaagtt caagcacaag ctgcatctcg ttttcgctgt ctatcagaag acacagcgcc      540

gttggttcct cgacaagctg gtggacgaga tcggtgtggg ttacgtgctg gactctggca      600

gcgtctcctt ttactcgctg tccgagatca agcctttgca taatttttta acacaactac      660

aaccttttct aaaactaaaa caaaaacaag caaatttagt tttaaaaatt attgaacaac      720

ttccgtcagc aaaagaatcc ccggacaaat tcttagaagt ttgtacatgg gtggatcaaa      780

ttgcagctct gaatgattcg aagacgcgta aaacaacttc tgaaaccgtt cgtgctgtgc      840

tagacagttt accaggatcc gtgggaggtc tatcgccatc tcaggcatcc agcgccgcat      900

cctcggcttc ctcaagcccg ggttcaggga tctccgaagc actcagagct ggagcaggtt      960

ccggcactgg atacaacaag gaattcctgc tctacctggc gggcttcgtc gacggggacg     1020

gctccatcta tgcccgtatc aagccggttc agcgggctaa gttcaagcac gagctggttc     1080

tcgggttcga tgtcactcag aagacacagc gccgttggtt cctcgacaag ctggtggacg     1140

agatcggtgt gggttacgtg tatgacaagg gcagcgtctc cgcgtaccgt ctgtcccaga     1200

tcaagcctct gcacaacttc ctgacccagc tccagccctt cctgaagctc aagcagaagc     1260

aggccaacct cgtgctgaag atcatcgagc agctgccctc cgccaaggaa tccccggaca     1320

agttcctgga ggtgtgcacc tgggtggacc agatcgccgc tctgaacgac tccaagaccc     1380

gcaagaccac ttccgaaacc gtccgcgccg ttctagacag tctctccgag aagaagaagt     1440

cgtcccccta aggtacgatc tgcctcgact gtgccttcta gttgccagcc atctgttgtt     1500

tgcccctccc ccgtgccttc cttgaccctg gaaggtgcca ctcccactgt cctttcctaa     1560

taaaatgagg aaattgcatc gcattgtctg agtaggtgtc attctattct ggggggtggg     1620

gtggggcagg acagcaaggg ggaggattgg gaagacaata gcaggcatgc tggggactcg     1680

agttaagggc gaattcccga taaggatctt cctagagcat ggctacgtag ataagtagca     1740

tggcgggtta atcattaact acaaggaacc cctagtgatg gagttggcca ctccctctct     1800

gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc gcccgacgcc cgggctttgc     1860

ccgggcggcc tcagtgagcg agcgagcgcg cag                                  1893


<210>  15
<211>  2625
<212>  DNA
<213>  Artificial sequence

<220>
<223>  PCSK7-8L.197


<220>
<221>  CDS
<222>  (1089)..(2183)
<223>  M2PCSK9 coding sequence

<400>  15
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagctagc aggttaattt ttaaaaagca gtcaaaagtc      240

caagtggccc ttggcagcat ttactctctc tgtttgctct ggttaataat ctcaggagca      300

caaacattcc agatccaggt taatttttaa aaagcagtca aaagtccaag tggcccttgg      360

cagcatttac tctctctgtt tgctctggtt aataatctca ggagcacaaa cattccagat      420

ccggcgcgcc agggctggaa gctacctttg acatcatttc ctctgcgaat gcatgtataa      480

tttctacaga acctattaga aaggatcacc cagcctctgc ttttgtacaa ctttccctta      540

aaaaactgcc aattccactg ctgtttggcc caatagtgag aactttttcc tgctgcctct      600

tggtgctttt gcctatggcc cctattctgc ctgctgaaga cactcttgcc agcatggact      660

taaacccctc cagctctgac aatcctcttt ctcttttgtt ttacatgaag ggtctggcag      720

ccaaagcaat cactcaaagt tcaaacctta tcattttttg ctttgttcct cttggccttg      780

gttttgtaca tcagctttga aaataccatc ccagggttaa tgctggggtt aatttataac      840

taagagtgct ctagttttgc aatacaggac atgctataaa aatggaaaga tgttgctttc      900

tgagagactg cagaagttgg tcgtgaggca ctgggcaggt aagtatcaag gttacaagac      960

aggtttaagg agaccaatag aaactgggct tgtcgagaca gagaagactc ttgcgtttct     1020

gataggcacc tattggtctt actgacatcc actttgcctt tctctccaca ggtgtccagg     1080

cggccgcc atg gca ccg aag aag aag cgc aag gtg cat atg aat aca aaa      1130
         Met Ala Pro Lys Lys Lys Arg Lys Val His Met Asn Thr Lys          
         1               5                   10                           

tat aat aaa gag ttc tta ctc tac tta gca ggg ttt gta gac ggt gac       1178
Tyr Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp           
15                  20                  25                  30            

ggt tcc atc ttt gcc agg atc aag cct agt caa cgt agt aag ttc aag       1226
Gly Ser Ile Phe Ala Arg Ile Lys Pro Ser Gln Arg Ser Lys Phe Lys           
                35                  40                  45                

cac aag ctg cat ctc gtt ttc gct gtc tat cag aag aca cag cgc cgt       1274
His Lys Leu His Leu Val Phe Ala Val Tyr Gln Lys Thr Gln Arg Arg           
            50                  55                  60                    

tgg ttc ctc gac aag ctg gtg gac gag atc ggt gtg ggt tac gtg ctg       1322
Trp Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Leu           
        65                  70                  75                        

gac tct ggc agc gtc tcc ttt tac tcg ctg tcc gag atc aag cct ttg       1370
Asp Ser Gly Ser Val Ser Phe Tyr Ser Leu Ser Glu Ile Lys Pro Leu           
    80                  85                  90                            

cat aat ttt tta aca caa cta caa cct ttt cta aaa cta aaa caa aaa       1418
His Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys           
95                  100                 105                 110           

caa gca aat tta gtt tta aaa att att gaa caa ctt ccg tca gca aaa       1466
Gln Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys           
                115                 120                 125               

gaa tcc ccg gac aaa ttc tta gaa gtt tgt aca tgg gtg gat caa att       1514
Glu Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile           
            130                 135                 140                   

gca gct ctg aat gat tcg aag acg cgt aaa aca act tct gaa acc gtt       1562
Ala Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val           
        145                 150                 155                       

cgt gct gtg cta gac agt tta cca gga tcc gtg gga ggt cta tcg cca       1610
Arg Ala Val Leu Asp Ser Leu Pro Gly Ser Val Gly Gly Leu Ser Pro           
    160                 165                 170                           

tct cag gca tcc agc gcc gca tcc tcg gct tcc tca agc ccg ggt tca       1658
Ser Gln Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser Ser Pro Gly Ser           
175                 180                 185                 190           

ggg atc tcc gaa gca ctc aga gct gga gca ggt tcc ggc act gga tac       1706
Gly Ile Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser Gly Thr Gly Tyr           
                195                 200                 205               

aac aag gaa ttc ctg ctc tac ctg gcg ggc ttc gtc gac ggg gac ggc       1754
Asn Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly           
            210                 215                 220                   

tcc atc tat gcc cgt atc aag ccg gtt cag cgg gct aag ttc aag cac       1802
Ser Ile Tyr Ala Arg Ile Lys Pro Val Gln Arg Ala Lys Phe Lys His           
        225                 230                 235                       

gag ctg gtt ctc ggg ttc gat gtc act cag aag aca cag cgc cgt tgg       1850
Glu Leu Val Leu Gly Phe Asp Val Thr Gln Lys Thr Gln Arg Arg Trp           
    240                 245                 250                           

ttc ctc gac aag ctg gtg gac gag atc ggt gtg ggt tac gtg tat gac       1898
Phe Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp           
255                 260                 265                 270           

aag ggc agc gtc tcc gcg tac cgt ctg tcc cag atc aag cct ctg cac       1946
Lys Gly Ser Val Ser Ala Tyr Arg Leu Ser Gln Ile Lys Pro Leu His           
                275                 280                 285               

aac ttc ctg acc cag ctc cag ccc ttc ctg aag ctc aag cag aag cag       1994
Asn Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln           
            290                 295                 300                   

gcc aac ctc gtg ctg aag atc atc gag cag ctg ccc tcc gcc aag gaa       2042
Ala Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu           
        305                 310                 315                       

tcc ccg gac aag ttc ctg gag gtg tgc acc tgg gtg gac cag atc gcc       2090
Ser Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala           
    320                 325                 330                           

gct ctg aac gac tcc aag acc cgc aag acc act tcc gaa acc gtc cgc       2138
Ala Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg           
335                 340                 345                 350           

gcc gtt cta gac agt ctc tcc gag aag aag aag tcg tcc ccc taa           2183
Ala Val Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser Ser Pro                   
                355                 360                                   

ggtacgatct gcctcgactg tgccttctag ttgccagcca tctgttgttt gcccctcccc     2243

cgtgccttcc ttgaccctgg aaggtgccac tcccactgtc ctttcctaat aaaatgagga     2303

aattgcatcg cattgtctga gtaggtgtca ttctattctg gggggtgggg tggggcagga     2363

cagcaagggg gaggattggg aagacaatag caggcatgct ggggactcga gttaagggcg     2423

aattcccgat aaggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa     2483

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     2543

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     2603

cagtgagcga gcgagcgcgc ag                                              2625


<210>  16
<211>  364
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic Construct

<400>  16

Met Ala Pro Lys Lys Lys Arg Lys Val His Met Asn Thr Lys Tyr Asn 
1               5                   10                  15      


Lys Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser 
            20                  25                  30          


Ile Phe Ala Arg Ile Lys Pro Ser Gln Arg Ser Lys Phe Lys His Lys 
        35                  40                  45              


Leu His Leu Val Phe Ala Val Tyr Gln Lys Thr Gln Arg Arg Trp Phe 
    50                  55                  60                  


Leu Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Leu Asp Ser 
65                  70                  75                  80  


Gly Ser Val Ser Phe Tyr Ser Leu Ser Glu Ile Lys Pro Leu His Asn 
                85                  90                  95      


Phe Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala 
            100                 105                 110         


Asn Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser 
        115                 120                 125             


Pro Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala 
    130                 135                 140                 


Leu Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala 
145                 150                 155                 160 


Val Leu Asp Ser Leu Pro Gly Ser Val Gly Gly Leu Ser Pro Ser Gln 
                165                 170                 175     


Ala Ser Ser Ala Ala Ser Ser Ala Ser Ser Ser Pro Gly Ser Gly Ile 
            180                 185                 190         


Ser Glu Ala Leu Arg Ala Gly Ala Gly Ser Gly Thr Gly Tyr Asn Lys 
        195                 200                 205             


Glu Phe Leu Leu Tyr Leu Ala Gly Phe Val Asp Gly Asp Gly Ser Ile 
    210                 215                 220                 


Tyr Ala Arg Ile Lys Pro Val Gln Arg Ala Lys Phe Lys His Glu Leu 
225                 230                 235                 240 


Val Leu Gly Phe Asp Val Thr Gln Lys Thr Gln Arg Arg Trp Phe Leu 
                245                 250                 255     


Asp Lys Leu Val Asp Glu Ile Gly Val Gly Tyr Val Tyr Asp Lys Gly 
            260                 265                 270         


Ser Val Ser Ala Tyr Arg Leu Ser Gln Ile Lys Pro Leu His Asn Phe 
        275                 280                 285             


Leu Thr Gln Leu Gln Pro Phe Leu Lys Leu Lys Gln Lys Gln Ala Asn 
    290                 295                 300                 


Leu Val Leu Lys Ile Ile Glu Gln Leu Pro Ser Ala Lys Glu Ser Pro 
305                 310                 315                 320 


Asp Lys Phe Leu Glu Val Cys Thr Trp Val Asp Gln Ile Ala Ala Leu 
                325                 330                 335     


Asn Asp Ser Lys Thr Arg Lys Thr Thr Ser Glu Thr Val Arg Ala Val 
            340                 345                 350         


Leu Asp Ser Leu Ser Glu Lys Lys Lys Ser Ser Pro 
        355                 360                 


<210>  17
<211>  2214
<212>  DNA
<213>  adeno-associated virus rh79


<220>
<221>  CDS
<222>  (1)..(2214)

<400>  17
atg gct gct gac ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc ccc aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aag gcc aac cag cag aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gag gcg gac gcc gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa gct gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gaa ccg tca cct cag cga tcc ccc gac tcc tcc acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aaa aaa ggc cag cag ccc gcg aga aag aga ctg aac ttt ggg cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtc ccc gac cct caa cca atc gga gaa cca        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro           
            180                 185                 190                   

cca gca ggc ccc tct ggt ctg gga tct ggt aca atg gct gca ggc ggt        624
Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gct cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc aat ggg aca tcg gga gga agc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgt cac ttc tca cca cgt gac tgg cag aga ctc atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg ccc aag aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtt aag gag gtc acg cag aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctt acc agc acg att cag gta ttt acg gac tcg gaa tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg ccg tac gtc ctc ggc tcc gcg cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gat gtc ttc atg att ccc cag tac ggc tac ctg aca ctg aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aac gga agt caa gcc gta ggc cgt tcc tca ttc tac tgc ctg gaa tat       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt cca tct caa atg ctg cgg act gga aac aac ttt gaa ttt agc tac       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr           
                405                 410                 415               

acc ttt gag gac gtg ccc ttc cac agc agc tac gca cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ctg gac cgg ctg atg aac cct ctc atc gac cag tac ctg tat tac cta       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tcc aga act cag tcc aca gga gga act caa ggt aca cag caa ttg tta       1392
Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu           
    450                 455                 460                           

ttt tct caa gcc ggg cct gca aat atg tcg gct cag gcc aag aac tgg       1440
Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp           
465                 470                 475                 480           

cta cct gga cct tgc tac cgg cag cag cga gtc tcc acg aca ctg tcg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser           
                485                 490                 495               

caa aac aac aac agc aac ttt gct tgg act ggt gcc acg aaa tat cat       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His           
            500                 505                 510                   

ctg aac gga aga gac tct ttg gtg aat ccc ggt gtt gct atg gca acg       1584
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr           
        515                 520                 525                       

cat aag gac gac gag gaa cgt ttc ttt cca tcg agc gga gtc ctg atg       1632
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met           
    530                 535                 540                           

ttt gga aaa cag ggt gct gga aga gac aat gtg gac tat agc agc gtt       1680
Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val           
545                 550                 555                 560           

atg cta acc agc gag gaa gaa atc aag acc act aac cct gta gcc act       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gaa caa tac ggc gtg gtg gct gat aac ttg cag caa acc aat aca gga       1776
Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly           
            580                 585                 590                   

cct atc gtg gga aat gtc aac agc caa gga gcc tta cct ggc atg gtc       1824
Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cga gac gtg tac ctg cag ggt ccc att tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gac ggc aac ttt cac ccg tct cct ctg atg ggc ggc ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

gga ctg aaa cac ccg cct cct caa atc ctg atc aag aac act ccc gtt       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct cca acg acg ttc agc cag gcg aaa ttg gct tcc ttc       2016
Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe           
            660                 665                 670                   

atc acg cag tat agt acc ggc cag gtc agc gtg gag atc gag tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gag aac agc aag cgc tgg aac cca gaa att cag tat act       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tcc aac tac tac aaa tct aca aat gtg gac ttt gct gtc aat acc gag       2160
Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

ggt aca tat tca gag cct cgc ccc att gga act cgt tac ctc acc cgt       2208
Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg                                                               2214
Asn Leu                                                                   
                                                                          


<210>  18
<211>  738
<212>  PRT
<213>  adeno-associated virus rh79

<400>  18

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  19
<211>  2214
<212>  DNA
<213>  adeno-associated virus 8


<220>
<221>  CDS
<222>  (1)..(2214)

<400>  19
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctg cag gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cca tca ccc cag cgt tct cca gac tcc tct acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc caa cag ccc gcc aga aaa aga ctc aat ttt ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtt cca gac cct caa cct ctc gga gaa cct        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro           
            180                 185                 190                   

cca gca gcg ccc tct ggt gtg gga cct aat aca atg gct gca ggc ggt        624
Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tcg gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc aac ggg aca tcg gga gga gcc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttt aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgc cac ttt tca cca cgt gac tgg cag cga ctc atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg ccc aag aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtc aag gag gtc acg cag aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctc acc agc acc atc cag gtg ttt acg gac tcg gag tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg ccg tac gtt ctc ggc tct gcc cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gac gtg ttc atg att ccc cag tac ggc tac cta aca ctc aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aac ggt agt cag gcc gtg gga cgc tcc tcc ttc tac tgc ctg gaa tac       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt cct tcg cag atg ctg aga acc ggc aac aac ttc cag ttt act tac       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr           
                405                 410                 415               

acc ttc gag gac gtg cct ttc cac agc agc tac gcc cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ttg gac cgg ctg atg aat cct ctg att gac cag tac ctg tac tac ttg       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tct cgg act caa aca aca gga ggc acg gca aat acg cag act ctg ggc       1392
Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly           
    450                 455                 460                           

ttc agc caa ggt ggg cct aat aca atg gcc aat cag gca aag aac tgg       1440
Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp           
465                 470                 475                 480           

ctg cca gga ccc tgt tac cgc caa caa cgc gtc tca acg aca acc ggg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly           
                485                 490                 495               

caa aac aac aat agc aac ttt gcc tgg act gct ggg acc aaa tac cat       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His           
            500                 505                 510                   

ctg aat gga aga aat tca ttg gct aat cct ggc atc gct atg gca aca       1584
Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr           
        515                 520                 525                       

cac aaa gac gac gag gag cgt ttt ttt ccc agt aac ggg atc ctg att       1632
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile           
    530                 535                 540                           

ttt ggc aaa caa aat gct gcc aga gac aat gcg gat tac agc gat gtc       1680
Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val           
545                 550                 555                 560           

atg ctc acc agc gag gaa gaa atc aaa acc act aac cct gtg gct aca       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gag gaa tac ggt atc gtg gca gat aac ttg cag cag caa aac acg gct       1776
Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala           
            580                 585                 590                   

cct caa att gga act gtc aac agc cag ggg gcc tta ccc ggt atg gtc       1824
Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cgg gac gtg tac ctg cag ggt ccc atc tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gac ggc aac ttc cac ccg tct ccg ctg atg ggc ggc ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

ggc ctg aaa cat cct ccg cct cag atc ctg atc aag aac acg cct gta       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct ccg acc acc ttc aac cag tca aag ctg aac tct ttc       2016
Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe           
            660                 665                 670                   

atc acg caa tac agc acc gga cag gtc agc gtg gaa att gaa tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gaa aac agc aag cgc tgg aac ccc gag atc cag tac acc       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tcc aac tac tac aaa tct aca agt gtg gac ttt gct gtt aat aca gaa       2160
Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

ggc gtg tac tct gaa ccc cgc ccc att ggc acc cgt tac ctc acc cgt       2208
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg                                                               2214
Asn Leu                                                                   
                                                                          


<210>  20
<211>  738
<212>  PRT
<213>  adeno-associated virus 8

<400>  20

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  21
<211>  2214
<212>  DNA
<213>  adeno-associated virus hu37


<220>
<221>  CDS
<222>  (1)..(2214)

<400>  21
atg gct gct gac ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc ccc aag ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aag gcc aac cag cag aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa gct gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gaa ccg tca cct cag cgt tcc ccc gac tcc tcc acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc cag cag ccc gct aaa aag aga ctg aac ttt ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtc ccc gac cct caa cca atc gga gaa cca        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro           
            180                 185                 190                   

cca gca ggc ccc tct ggt ctg gga tct ggt aca atg gct gca ggc ggt        624
Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gct cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa ata tcc aat ggg aca tcg gga gga agc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttc aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctc atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg cca aaa aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtc aag gag gtc acg cag aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctt acc agc acg att cag gta ttt acg gac tcg gaa tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg ccg tac gtc ctc ggc tcc gcg cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gac gtc ttc atg att ccc cag tac ggc tac ctt aca ctg aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aat gga agt caa gcc gta ggc cgt tcc tcc ttc tac tgc ctg gaa tat       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt cca tct caa atg ctg cga act gga aac aat ttt gaa ttc agc tac       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr           
                405                 410                 415               

acc ttc gag gac gtg cct ttc cac agc agc tac gca cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ttg gac cga ctg atg aat cct ctc atc gac cag tac ctg tac tac tta       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tcc aga act cag tcc aca gga gga act caa ggt acc cag caa ttg tta       1392
Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu           
    450                 455                 460                           

ttt tct caa gct ggg cct gca aac atg tcg gct cag gct aag aac tgg       1440
Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp           
465                 470                 475                 480           

cta cct gga cct tgc tac cgg cag cag cga gtc tct acg aca ctg tcg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser           
                485                 490                 495               

caa aac aac aac agc aac ttt gct tgg act ggt gcc acc aaa tat cac       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His           
            500                 505                 510                   

ctg aac gga aga gac tct ttg gta aat ccc ggt gtc gcc atg gca acc       1584
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr           
        515                 520                 525                       

cac aag gac gac gag gaa cgc ttc ttc ccg tcg agt gga gtc ctg atg       1632
His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met           
    530                 535                 540                           

ttc gga aaa cag ggt gct gga aga gac aat gtg gac tac agc agc gtt       1680
Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val           
545                 550                 555                 560           

atg cta acc agc gaa gaa gaa att aaa acc act aac ccc gta gcc aca       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gaa caa tac ggt gtg gtg gct gac aac ttg cag caa acc aat aca ggg       1776
Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly           
            580                 585                 590                   

cct att gtg gga aat gtc aac agc caa gga gcc tta cct ggc atg gtc       1824
Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cga gac gtg tac ctg cag ggt ccc atc tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gac ggc aac ttc cac cct tca ccg cta atg gga gga ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

gga ctg aag cac cca cct cct cag atc ctg atc aag aac acg ccg gta       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct cca aca acg ttc agc cag gcg aaa ttg gct tcc ttc       2016
Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe           
            660                 665                 670                   

att acg cag tac agc acc gga cag gtc agc gtg gaa atc gag tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gag aac agc aaa cgc tgg aac cca gag att cag tac act       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tca aac tac tac aaa tct aca aat gtg gac ttt gct gtc aat aca gag       2160
Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

gga act tat tct gag cct cgc ccc att ggt act cgt tac ctc acc cgt       2208
Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg                                                               2214
Asn Leu                                                                   
                                                                          


<210>  22
<211>  738
<212>  PRT
<213>  adeno-associated virus hu37

<400>  22

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Ile Gly Glu Pro 
            180                 185                 190         


Pro Ala Gly Pro Ser Gly Leu Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Glu Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Gln Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Ala Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Ser Gly Val Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Arg Asp Asn Val Asp Tyr Ser Ser Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Thr Asn Thr Gly 
            580                 585                 590         


Pro Ile Val Gly Asn Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Ser Gln Ala Lys Leu Ala Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Thr Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  23
<211>  2217
<212>  DNA
<213>  adeno-associated virus rh.90


<220>
<221>  CDS
<222>  (1)..(2217)

<400>  23
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gac ctg aaa cct gga gcc cca aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctg cag gcg ggt gat aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tca ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ctc ggt ctg gtt gag gaa ggc gct aag acg gct cct gga aag aag aga        432
Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cca tca cca cag cgt tcc ccc gac tcc tcc acg ggc atc        480
Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile           
145                 150                 155                 160           

ggc aag aaa ggc cag cag ccc gcc aga aag aga ctc aat ttc ggt cag        528
Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln           
                165                 170                 175               

act ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct        576
Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro           
            180                 185                 190                   

cca gca gcg ccc tct agt gtg gga tct ggt aca atg gct gca ggc ggt        624
Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly           
        195                 200                 205                       

ggc gca cca atg gca gac aat aac gaa ggt gcc gac gga gtg ggt agt        672
Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser           
    210                 215                 220                           

tcc tcg gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc        720
Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val           
225                 230                 235                 240           

atc acc acc agc acc cga acc tgg gcc ctg ccc acc tac aac aac cac        768
Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His           
                245                 250                 255               

ctc tac aag caa atc tcc aac ggg acc tcg gga ggc agc acc aac gac        816
Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp           
            260                 265                 270                   

aac acc tac ttc ggc tac agc acc ccc tgg ggg tat ttt gac ttt aac        864
Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn           
        275                 280                 285                       

aga ttc cac tgc cac ttc tca cca cgt gac tgg cag cga ctt atc aac        912
Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn           
    290                 295                 300                           

aac aac tgg gga ttc cgg ccc aag aga ctc agc ttc aag ctc ttc aac        960
Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn           
305                 310                 315                 320           

atc cag gtc aag gag gtc acg caa aat gaa ggc acc aag acc atc gcc       1008
Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala           
                325                 330                 335               

aat aac ctc acc agc acc atc cag gtg ttt acg gac tcg gaa tac cag       1056
Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln           
            340                 345                 350                   

ctg cca tac gtc ctc ggc tct gcc cac cag ggc tgc ctg cct ccg ttc       1104
Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe           
        355                 360                 365                       

ccg gcg gac gtc ttc atg att cct cag tat ggc tac ctg acg ctg aac       1152
Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn           
    370                 375                 380                           

aac gga agt cag gcc gtg ggc cgt tcc tcc ttc tac tgc ctg gag tac       1200
Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr           
385                 390                 395                 400           

ttt ccc tct cag atg cta aga acg ggc aac aac ttc tcc ttc agc tat       1248
Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr           
                405                 410                 415               

acc ttc gag gac gtg cct ttc cac agc agc tac gcg cac agc cag agc       1296
Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser           
            420                 425                 430                   

ctg gac cgg ctg atg aat ccc ctc att gac cag tac ctg tac tac ctg       1344
Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu           
        435                 440                 445                       

tcg cgg aca caa tcc aca gga ggc aca gcg gga act cag cag ttg ctg       1392
Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu           
    450                 455                 460                           

ttt tct cag gcc ggg cct aac aac atg tct gct cag gcc aaa aac tgg       1440
Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp           
465                 470                 475                 480           

cta ccc gga cct tgt tat cgg cag caa cgt gtt tcc acg aca ctg tcg       1488
Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser           
                485                 490                 495               

caa aac aac aac agc aac ttt gcc tgg acc ggt gcc acc aaa tac cac       1536
Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His           
            500                 505                 510                   

ctg aac gga aga gac tct ctg gta aat ccg ggt gtc gcc atg gca acc       1584
Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr           
        515                 520                 525                       

aac aag gac gac gag gac cgc ttc ttc cca tcc agc ggc atc ctc atg       1632
Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met           
    530                 535                 540                           

ttt ggc aag cag ggg gct gga aaa gac aac gtg gac tat agc aac gtg       1680
Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val           
545                 550                 555                 560           

atg cta acc agc gag gaa gaa atc aag acc act aac cct gtg gcc aca       1728
Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr           
                565                 570                 575               

gaa cag tat ggt gtg gtg gcg gat aac ctg cag cag caa aac aca gct       1776
Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala           
            580                 585                 590                   

cct att gtg ggg gcc gtc aac agc caa gga gcc tta cct ggc atg gtt       1824
Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val           
        595                 600                 605                       

tgg cag aac cgg gac gtg tac ctg cag ggt ccc atc tgg gcc aag att       1872
Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile           
    610                 615                 620                           

cct cac acg gat ggt aac ttt cac ccg tct cct ctc atg ggc ggc ttt       1920
Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe           
625                 630                 635                 640           

gga ctt aaa cat ccg cct cct cag atc ctg atc aag aac act ccc gtt       1968
Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val           
                645                 650                 655               

cct gcg gat cct cca acg gcg ttc aac cag gcc aag ctg aac tct ttc       2016
Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe           
            660                 665                 670                   

atc acg cag tac agc acc gga caa gtc agc gtg gag atc gag tgg gag       2064
Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu           
        675                 680                 685                       

ctg cag aag gag aac agc aag cgc tgg aac cca gag att cag tat acc       2112
Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr           
    690                 695                 700                           

tcc aac tac tac aaa tct aca aat gtg gac ttt gct gtt aat act gag       2160
Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu           
705                 710                 715                 720           

ggt gtt tac tct gag cct cgc ccc att ggc acc cgt tac ctc acc cgt       2208
Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg           
                725                 730                 735               

aat ctg taa                                                           2217
Asn Leu                                                                   
                                                                          


<210>  24
<211>  738
<212>  PRT
<213>  adeno-associated virus rh.90

<400>  24

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Asp Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Ser Val Gly Ser Gly Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ser Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Ser Phe Ser Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Ser Thr Gly Gly Thr Ala Gly Thr Gln Gln Leu Leu 
    450                 455                 460                 


Phe Ser Gln Ala Gly Pro Asn Asn Met Ser Ala Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Leu Ser 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Gly Ala Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Val Ala Met Ala Thr 
        515                 520                 525             


Asn Lys Asp Asp Glu Asp Arg Phe Phe Pro Ser Ser Gly Ile Leu Met 
    530                 535                 540                 


Phe Gly Lys Gln Gly Ala Gly Lys Asp Asn Val Asp Tyr Ser Asn Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Gln Tyr Gly Val Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Ile Val Gly Ala Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Ala Phe Asn Gln Ala Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Asn Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  25
<211>  176
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  constructed sequence

<400>  25
actcaaagtt caaaccttat cattttttgc tttgttcctc ttggccttgg ttttgtacat       60

cagctttgaa aataccatcc cagggttaat gctggggtta atttataact aagagtgctc      120

tagttttgca atacaggaca tgctataaaa atggaaagat gttgctttct gagaga          176


