                         SEQUENCE LISTING

<110>  THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
 
<120>  Composition useful in treatment of CDKL5 deficiency disorder 
       (CDD)

<130>  UPN-20-9196.PCT

<150>  US 63/016,036
<151>  2020-04-27

<150>  US 63/091,032
<151>  2020-10-13

<150>  US 63/109,608
<151>  2020-11-04

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  4634
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV 2 seq upstream of 3'ITR

<220>
<221>  promoter
<222>  (213)..(678)
<223>  hSynapsin

<220>
<221>  CDS
<222>  (699)..(3581)
<223>  hCDKL5_1

<220>
<221>  misc_feature
<222>  (3596)..(4183)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (4201)..(4439)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (4467)..(44505)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  repeat_region
<222>  (4505)..(4634)
<223>  3'ITR

<400>  1
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gcctgcagag ggccctgcgt atgagtgcaa      240

gtgggtttta ggaccaggat gaggcggggt gggggtgcct acctgacgac cgaccccgac      300

ccactggaca agcacccaac ccccattccc caaattgcgc atcccctatc agagaggggg      360

aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag cttcagcacc gcggacagtg      420

ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca gcactgaagg cgcgctgacg      480

tcactcgccg gtcccccgca aactcccctt cccggccacc ttggtcgcgt ccgcgccgcc      540

gccggcccag ccggaccgca ccacgcgagg cgcgagatag gggggcacgg gcgcgaccat      600

ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg cggtgggcag cggaggagtc      660

gtgtcgtgcc tgagagcgca gtcgaattcg ccgccacc atg aag atc ccc aac atc      716
                                          Met Lys Ile Pro Asn Ile         
                                          1               5               

ggc aac gtg atg aac aag ttc gag atc ctg ggc gtt gtc gga gaa ggc        764
Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly           
            10                  15                  20                    

gct tat ggc gtg gtg ctg aag tgc aga cac aaa gaa acc cac gag atc        812
Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile           
        25                  30                  35                        

gtg gcc atc aag aag ttc aag gac agc gaa gag aac gag gaa gtg aaa        860
Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys           
    40                  45                  50                            

gag aca acc ctg cgc gag ctg aag atg ctg aga acc ctg aag caa gag        908
Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu           
55                  60                  65                  70            

aac atc gtg gaa ctg aaa gag gcc ttc cgg cgg aga ggc aag ctg tac        956
Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr           
                75                  80                  85                

ctg gtg ttc gag tac gtg gaa aag aac atg ctc gag ctg ctg gaa gag       1004
Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu           
            90                  95                  100                   

atg ccc aat ggc gtg cca cct gag aaa gtg aag tcc tac atc tac cag       1052
Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln           
        105                 110                 115                       

ctg atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac aga       1100
Leu Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg           
    120                 125                 130                           

gac atc aag ccc gag aac ctg ctg atc tcc cac aac gac gtg ctg aag       1148
Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys           
135                 140                 145                 150           

ctg tgc gac ttc ggc ttc gcc aga aat ctg agc gag ggc aac aac gcc       1196
Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala           
                155                 160                 165               

aac tac acc gag tat gtg gcc acc aga tgg tac aga agc cct gaa ctg       1244
Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu           
            170                 175                 180                   

ctg ctg gga gcc cct tac ggc aag tct gtg gat atg tgg tcc gtg ggc       1292
Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly           
        185                 190                 195                       

tgt atc ctg gga gag ctg tct gat ggc caa cct ctg ttt cct ggc gag       1340
Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu           
    200                 205                 210                           

tcc gag atc gac cag ctg ttc aca atc cag aag gtg ctg ggc cct ctg       1388
Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu           
215                 220                 225                 230           

cct agc gag cag atg aag ctg ttc tac agc aac ccc aga ttc cac ggc       1436
Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly           
                235                 240                 245               

ctg aga ttc cct gcc gtg aat cac cct cag agc ctg gaa aga aga tac       1484
Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr           
            250                 255                 260                   

ctg ggc atc ctg aac agc gtg ctg ctg gac ctg atg aag aat ctg ctg       1532
Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu           
        265                 270                 275                       

aaa ctg gac ccc gcc gac aga tac ctg acc gag cag tgt ctg aac cat       1580
Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His           
    280                 285                 290                           

cct acc ttt cag acc cag aga ctg ctg gat aga agc ccc agc aga agc       1628
Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser           
295                 300                 305                 310           

gcc aag aga aag ccc tac cac gtg gaa agc agc acc ctg agc aat aga       1676
Ala Lys Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg           
                315                 320                 325               

aac cag gcc gga aag agc act gcc ctg cag agc cac cac aga agc aac       1724
Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn           
            330                 335                 340                   

agc aag gac atc cag aac ctg agc gtg ggc ctg cct aga gct gat gaa       1772
Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu           
        345                 350                 355                       

gga ctg cct gcc aac gag agc ttc ctg aat gga aat ctg gct ggc gcc       1820
Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala           
    360                 365                 370                           

tct ctg agc cct ctg cac aca aag aca tac cag gcc agc agc cag cct       1868
Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro           
375                 380                 385                 390           

ggc agc aca agc aag gac ctg acc aac aac aac atc cct cat ctg ctg       1916
Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu           
                395                 400                 405               

agc ccc aaa gag gcc aag agc aag acc gag ttc gac ttc aac atc gac       1964
Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp           
            410                 415                 420                   

ccc aag cct agc gaa ggc cct ggc acc aag tac ctg aag tcc aac tcc       2012
Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser           
        425                 430                 435                       

aga agc cag cag aac cgg cac tcc ttc atg gaa agc tct cag agc aag       2060
Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys           
    440                 445                 450                           

gcc ggc aca ctg cag cct aac gag aag cag agc aga cac agc tac atc       2108
Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile           
455                 460                 465                 470           

gac aca atc cct cag tcc tct cgg agc ccc agc tac aga aca aag gcc       2156
Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala           
                475                 480                 485               

aaa tct cac ggc gcc ctg agc gat agc aag agc gtg tcc aat ctg tcc       2204
Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser           
            490                 495                 500                   

gag gct aga gcc cag atc gcc gag cct agc acc agc aga tac ttc cct       2252
Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro           
        505                 510                 515                       

agc agc tgc ctg gat ctg aac agc cct aca agc ccc aca cct acc agg       2300
Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg           
    520                 525                 530                           

cac agc gat acc aga aca ctg ctg tcc cca agc ggc cgg aac aac aga       2348
His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg           
535                 540                 545                 550           

aat gag ggc acc ctg gac agc aga cgg acc acc aca aga cac agc aag       2396
Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys           
                555                 560                 565               

acc atg gaa gaa ctg aag ctg ccc gag cac atg gac tct agc cac tct       2444
Thr Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser           
            570                 575                 580                   

cat tct ctg agc gcc cct cac gag tcc ttt agc tac ggc ctg ggc tac       2492
His Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr           
        585                 590                 595                       

aca agc cca ttt tcc agt cag cag cgg ccc cac aga cac tct atg tac       2540
Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr           
    600                 605                 610                           

gtg acc aga gac aaa gtc cgc gcc aaa ggc ctg gat ggc tct ctg tct       2588
Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser           
615                 620                 625                 630           

att gga caa ggc atg gcc gcc aga gcc aat agc ctg caa ctt ctg tct       2636
Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser           
                635                 640                 645               

cct cag cct ggc gaa cag ctg cct cct gaa atg aca gtg gcc cgg tcc       2684
Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser           
            650                 655                 660                   

agc gtg aaa gaa acc agc aga gag ggc acc tcc agc ttc cac acc aga       2732
Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg           
        665                 670                 675                       

cag aaa agc gaa ggc ggc gtg tac cac gat cct cac tct gat gat ggc       2780
Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly           
    680                 685                 690                           

aca gcc cct aaa gag aac aga cac ctg tac aac gac ccc gtg cct aga       2828
Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg           
695                 700                 705                 710           

aga gtg ggc tcc ttc tac aga gtg cct tct cct aga cct gac aac tcc       2876
Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser           
                715                 720                 725               

ttc cac gag aac aac gtg tca acc cgg gtg tcc agc ctg cct tct gag       2924
Phe His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu           
            730                 735                 740                   

agc agc tct ggc aca aac cac tcc aag agg cag ccc gcc ttc gat cct       2972
Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro           
        745                 750                 755                       

tgg aag tcc cct gag aat atc agc cac tcc gag cag ctg aaa gag aaa       3020
Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys           
    760                 765                 770                           

gag aag cag ggc ttt ttc cgg tcc atg aag aag aag aaa aag aag tcc       3068
Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser           
775                 780                 785                 790           

cag aca gtc ccc aac agc gac agc cct gat ctc ctg aca ctg cag aag       3116
Gln Thr Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys           
                795                 800                 805               

tcc atc cac agc gcc agc aca cct agc agc aga cct aaa gag tgg cgg       3164
Ser Ile His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg           
            810                 815                 820                   

cca gag aag atc agc gac ctg caa aca cag agc cag cct ctg aag tcc       3212
Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser           
        825                 830                 835                       

ctg agg aag ctg ctg cat ctg tcc tcc gcc tct aat cac cct gcc agc       3260
Leu Arg Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser           
    840                 845                 850                           

agc gat ccc aga ttt cag cca ctg aca gcc cag cag acc aag aac tcc       3308
Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser           
855                 860                 865                 870           

ttc agc gag atc cgg att cac cca ctg tct cag gcc agc ggc ggc agc       3356
Phe Ser Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser           
                875                 880                 885               

tct aat atc aga caa gag ccc gct cct aag ggc aga cct gct ctc caa       3404
Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln           
            890                 895                 900                   

ctg cct gga cag atg gat cct ggc tgg cac gtg tcc tct gtg aca aga       3452
Leu Pro Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg           
        905                 910                 915                       

tct gcc acc gag gga cct agc tat tct gag cag ctg ggc gcc aag tct       3500
Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser           
    920                 925                 930                           

ggc ccc aat gga cac ccc tac aac cgg acc aat cgg agc aga atg ccc       3548
Gly Pro Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro           
935                 940                 945                 950           

aac ctg aac gac ctc aaa gaa aca gcc ctc tga gagcttatcg ataatcaacc     3601
Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu                                   
                955                 960                                   

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     3661

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     3721

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     3781

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     3841

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     3901

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     3961

tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt     4021

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     4081

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     4141

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgatacc gtcgatcgag     4201

gccgcttcga gcagacatga taagatacat tgatgagttt ggacaaacca caactagaat     4261

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     4321

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     4381

gggggagatg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga     4441

taaggatctt cctagagcat ggctacgtag ataagtagca tggcgggtta atcattaact     4501

acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     4561

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     4621

agcgagcgcg cag                                                        4634


<210>  2
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  2

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210>  3
<211>  4750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq usptream of 3'ITR

<220>
<221>  promoter
<222>  (213)..(678)
<223>  hSynapsin

<220>
<221>  CDS
<222>  (699)..(3581)
<223>  hCDKL5-1

<220>
<221>  misc_binding
<222>  (3590)..(3705)
<223>  miR183

<220>
<221>  misc_feature
<222>  (3712)..(4299)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (4317)..(4555)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (4583)..(4621)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  repeat_region
<222>  (4621)..(4750)
<223>  3'ITR

<400>  3
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gcctgcagag ggccctgcgt atgagtgcaa      240

gtgggtttta ggaccaggat gaggcggggt gggggtgcct acctgacgac cgaccccgac      300

ccactggaca agcacccaac ccccattccc caaattgcgc atcccctatc agagaggggg      360

aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag cttcagcacc gcggacagtg      420

ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca gcactgaagg cgcgctgacg      480

tcactcgccg gtcccccgca aactcccctt cccggccacc ttggtcgcgt ccgcgccgcc      540

gccggcccag ccggaccgca ccacgcgagg cgcgagatag gggggcacgg gcgcgaccat      600

ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg cggtgggcag cggaggagtc      660

gtgtcgtgcc tgagagcgca gtcgaattcg ccgccacc atg aag atc ccc aac atc      716
                                          Met Lys Ile Pro Asn Ile         
                                          1               5               

ggc aac gtg atg aac aag ttc gag atc ctg ggc gtt gtc gga gaa ggc        764
Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly           
            10                  15                  20                    

gct tat ggc gtg gtg ctg aag tgc aga cac aaa gaa acc cac gag atc        812
Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile           
        25                  30                  35                        

gtg gcc atc aag aag ttc aag gac agc gaa gag aac gag gaa gtg aaa        860
Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys           
    40                  45                  50                            

gag aca acc ctg cgc gag ctg aag atg ctg aga acc ctg aag caa gag        908
Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu           
55                  60                  65                  70            

aac atc gtg gaa ctg aaa gag gcc ttc cgg cgg aga ggc aag ctg tac        956
Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr           
                75                  80                  85                

ctg gtg ttc gag tac gtg gaa aag aac atg ctc gag ctg ctg gaa gag       1004
Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu           
            90                  95                  100                   

atg ccc aat ggc gtg cca cct gag aaa gtg aag tcc tac atc tac cag       1052
Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln           
        105                 110                 115                       

ctg atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac aga       1100
Leu Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg           
    120                 125                 130                           

gac atc aag ccc gag aac ctg ctg atc tcc cac aac gac gtg ctg aag       1148
Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys           
135                 140                 145                 150           

ctg tgc gac ttc ggc ttc gcc aga aat ctg agc gag ggc aac aac gcc       1196
Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala           
                155                 160                 165               

aac tac acc gag tat gtg gcc acc aga tgg tac aga agc cct gaa ctg       1244
Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu           
            170                 175                 180                   

ctg ctg gga gcc cct tac ggc aag tct gtg gat atg tgg tcc gtg ggc       1292
Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly           
        185                 190                 195                       

tgt atc ctg gga gag ctg tct gat ggc caa cct ctg ttt cct ggc gag       1340
Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu           
    200                 205                 210                           

tcc gag atc gac cag ctg ttc aca atc cag aag gtg ctg ggc cct ctg       1388
Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu           
215                 220                 225                 230           

cct agc gag cag atg aag ctg ttc tac agc aac ccc aga ttc cac ggc       1436
Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly           
                235                 240                 245               

ctg aga ttc cct gcc gtg aat cac cct cag agc ctg gaa aga aga tac       1484
Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr           
            250                 255                 260                   

ctg ggc atc ctg aac agc gtg ctg ctg gac ctg atg aag aat ctg ctg       1532
Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu           
        265                 270                 275                       

aaa ctg gac ccc gcc gac aga tac ctg acc gag cag tgt ctg aac cat       1580
Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His           
    280                 285                 290                           

cct acc ttt cag acc cag aga ctg ctg gat aga agc ccc agc aga agc       1628
Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser           
295                 300                 305                 310           

gcc aag aga aag ccc tac cac gtg gaa agc agc acc ctg agc aat aga       1676
Ala Lys Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg           
                315                 320                 325               

aac cag gcc gga aag agc act gcc ctg cag agc cac cac aga agc aac       1724
Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn           
            330                 335                 340                   

agc aag gac atc cag aac ctg agc gtg ggc ctg cct aga gct gat gaa       1772
Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu           
        345                 350                 355                       

gga ctg cct gcc aac gag agc ttc ctg aat gga aat ctg gct ggc gcc       1820
Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala           
    360                 365                 370                           

tct ctg agc cct ctg cac aca aag aca tac cag gcc agc agc cag cct       1868
Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro           
375                 380                 385                 390           

ggc agc aca agc aag gac ctg acc aac aac aac atc cct cat ctg ctg       1916
Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu           
                395                 400                 405               

agc ccc aaa gag gcc aag agc aag acc gag ttc gac ttc aac atc gac       1964
Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp           
            410                 415                 420                   

ccc aag cct agc gaa ggc cct ggc acc aag tac ctg aag tcc aac tcc       2012
Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser           
        425                 430                 435                       

aga agc cag cag aac cgg cac tcc ttc atg gaa agc tct cag agc aag       2060
Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys           
    440                 445                 450                           

gcc ggc aca ctg cag cct aac gag aag cag agc aga cac agc tac atc       2108
Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile           
455                 460                 465                 470           

gac aca atc cct cag tcc tct cgg agc ccc agc tac aga aca aag gcc       2156
Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala           
                475                 480                 485               

aaa tct cac ggc gcc ctg agc gat agc aag agc gtg tcc aat ctg tcc       2204
Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser           
            490                 495                 500                   

gag gct aga gcc cag atc gcc gag cct agc acc agc aga tac ttc cct       2252
Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro           
        505                 510                 515                       

agc agc tgc ctg gat ctg aac agc cct aca agc ccc aca cct acc agg       2300
Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg           
    520                 525                 530                           

cac agc gat acc aga aca ctg ctg tcc cca agc ggc cgg aac aac aga       2348
His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg           
535                 540                 545                 550           

aat gag ggc acc ctg gac agc aga cgg acc acc aca aga cac agc aag       2396
Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys           
                555                 560                 565               

acc atg gaa gaa ctg aag ctg ccc gag cac atg gac tct agc cac tct       2444
Thr Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser           
            570                 575                 580                   

cat tct ctg agc gcc cct cac gag tcc ttt agc tac ggc ctg ggc tac       2492
His Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr           
        585                 590                 595                       

aca agc cca ttt tcc agt cag cag cgg ccc cac aga cac tct atg tac       2540
Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr           
    600                 605                 610                           

gtg acc aga gac aaa gtc cgc gcc aaa ggc ctg gat ggc tct ctg tct       2588
Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser           
615                 620                 625                 630           

att gga caa ggc atg gcc gcc aga gcc aat agc ctg caa ctt ctg tct       2636
Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser           
                635                 640                 645               

cct cag cct ggc gaa cag ctg cct cct gaa atg aca gtg gcc cgg tcc       2684
Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser           
            650                 655                 660                   

agc gtg aaa gaa acc agc aga gag ggc acc tcc agc ttc cac acc aga       2732
Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg           
        665                 670                 675                       

cag aaa agc gaa ggc ggc gtg tac cac gat cct cac tct gat gat ggc       2780
Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly           
    680                 685                 690                           

aca gcc cct aaa gag aac aga cac ctg tac aac gac ccc gtg cct aga       2828
Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg           
695                 700                 705                 710           

aga gtg ggc tcc ttc tac aga gtg cct tct cct aga cct gac aac tcc       2876
Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser           
                715                 720                 725               

ttc cac gag aac aac gtg tca acc cgg gtg tcc agc ctg cct tct gag       2924
Phe His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu           
            730                 735                 740                   

agc agc tct ggc aca aac cac tcc aag agg cag ccc gcc ttc gat cct       2972
Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro           
        745                 750                 755                       

tgg aag tcc cct gag aat atc agc cac tcc gag cag ctg aaa gag aaa       3020
Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys           
    760                 765                 770                           

gag aag cag ggc ttt ttc cgg tcc atg aag aag aag aaa aag aag tcc       3068
Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser           
775                 780                 785                 790           

cag aca gtc ccc aac agc gac agc cct gat ctc ctg aca ctg cag aag       3116
Gln Thr Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys           
                795                 800                 805               

tcc atc cac agc gcc agc aca cct agc agc aga cct aaa gag tgg cgg       3164
Ser Ile His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg           
            810                 815                 820                   

cca gag aag atc agc gac ctg caa aca cag agc cag cct ctg aag tcc       3212
Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser           
        825                 830                 835                       

ctg agg aag ctg ctg cat ctg tcc tcc gcc tct aat cac cct gcc agc       3260
Leu Arg Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser           
    840                 845                 850                           

agc gat ccc aga ttt cag cca ctg aca gcc cag cag acc aag aac tcc       3308
Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser           
855                 860                 865                 870           

ttc agc gag atc cgg att cac cca ctg tct cag gcc agc ggc ggc agc       3356
Phe Ser Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser           
                875                 880                 885               

tct aat atc aga caa gag ccc gct cct aag ggc aga cct gct ctc caa       3404
Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln           
            890                 895                 900                   

ctg cct gga cag atg gat cct ggc tgg cac gtg tcc tct gtg aca aga       3452
Leu Pro Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg           
        905                 910                 915                       

tct gcc acc gag gga cct agc tat tct gag cag ctg ggc gcc aag tct       3500
Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser           
    920                 925                 930                           

ggc ccc aat gga cac ccc tac aac cgg acc aat cgg agc aga atg ccc       3548
Gly Pro Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro           
935                 940                 945                 950           

aac ctg aac gac ctc aaa gaa aca gcc ctc tga gagcttatac cggtagtgaa     3601
Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu                                   
                955                 960                                   

ttctaccagt gccataggat agtgaattct accagtgcca tacacgtgag tgaattctac     3661

cagtgccata gcatgcagtg aattctacca gtgccatagg tacccgataa tcaacctctg     3721

gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc ttttacgcta     3781

tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat ggctttcatt     3841

ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg gcccgttgtc     3901

aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg ttggggcatt     3961

gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat tgccacggcg     4021

gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt gggcactgac     4081

aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc ctgtgttgcc     4141

acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa tccagcggac     4201

cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg ccttcgccct     4261

cagacgagtc ggatctccct ttgggccgcc tccccgcatc gataccgtcg atcgaggccg     4321

cttcgagcag acatgataag atacattgat gagtttggac aaaccacaac tagaatgcag     4381

tgaaaaaaat gctttatttg tgaaatttgt gatgctattg ctttatttgt aaccattata     4441

agctgcaata aacaagttaa caacaacaat tgcattcatt ttatgtttca ggttcagggg     4501

gagatgtggg aggtttttta aagcaagtaa aacctctaca aatgtggtaa aatcgataag     4561

gatcttccta gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa     4621

ggaaccccta gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc     4681

cgggcgacca aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg     4741

agcgcgcag                                                             4750


<210>  4
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  4

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210>  5
<211>  4757
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq usptream of 3'ITR

<220>
<221>  promoter
<222>  (213)..(678)
<223>  hSynapsin

<220>
<221>  misc_feature
<222>  (690)..(695)
<223>  Kozak

<220>
<221>  CDS
<222>  (696)..(3704)
<223>  hCDKL5-2GS

<220>
<221>  misc_feature
<222>  (3719)..(4306)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (4324)..(4562)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (4590)..(4628)
<223>  AAV2 seq usptream of 3'ITR

<220>
<221>  repeat_region
<222>  (4628)..(4757)
<223>  3'ITR

<400>  5
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gcctgcagag ggccctgcgt atgagtgcaa      240

gtgggtttta ggaccaggat gaggcggggt gggggtgcct acctgacgac cgaccccgac      300

ccactggaca agcacccaac ccccattccc caaattgcgc atcccctatc agagaggggg      360

aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag cttcagcacc gcggacagtg      420

ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca gcactgaagg cgcgctgacg      480

tcactcgccg gtcccccgca aactcccctt cccggccacc ttggtcgcgt ccgcgccgcc      540

gccggcccag ccggaccgca ccacgcgagg cgcgagatag gggggcacgg gcgcgaccat      600

ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg cggtgggcag cggaggagtc      660

gtgtcgtgcc tgagagcgca gtcgaattcg ccacc atg aag atc ccc aat atc         713
                                       Met Lys Ile Pro Asn Ile            
                                       1               5                  

ggc aac gtg atg aat aag ttc gag atc ctg gga gtg gtg gga gag gga        761
Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly           
            10                  15                  20                    

gca tac ggc gtg gtg ctg aag tgc aga cac aag gag aca cac gag atc        809
Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile           
        25                  30                  35                        

gtg gcc atc aag aag ttt aag gat agc gag gag aat gag gag gtg aag        857
Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys           
    40                  45                  50                            

gag aca acc ctg cgc gag ctg aag atg ctg cgg aca ctg aag cag gag        905
Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu           
55                  60                  65                  70            

aac atc gtg gag ctg aag gag gcc ttc cgg aga agg ggc aag ctg tac        953
Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr           
                75                  80                  85                

ctg gtg ttt gag tac gtg gag aag aac atg ctg gag ctg ctg gag gag       1001
Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu           
            90                  95                  100                   

atg cct aat ggc gtg ccc cct gag aag gtg aag agc tac atc tat cag       1049
Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln           
        105                 110                 115                       

ctg atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac cgc       1097
Leu Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg           
    120                 125                 130                           

gat atc aag cca gag aac ctg ctg atc agc cac aat gac gtg ctg aag       1145
Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys           
135                 140                 145                 150           

ctg tgc gat ttc ggc ttt gcc cgg aac ctg tcc gag ggc aac aac gcc       1193
Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala           
                155                 160                 165               

aat tac aca gag tac gtg gca acc agg tgg tac cgg tcc cct gag ctg       1241
Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu           
            170                 175                 180                   

ctg ctg gga gca cca tac ggc aag tct gtg gac atg tgg agc gtg ggc       1289
Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly           
        185                 190                 195                       

tgc atc ctg gga gag ctg tcc gac gga cag cca ctg ttc cct ggc gag       1337
Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu           
    200                 205                 210                           

tct gag atc gat cag ctg ttt acc atc cag aag gtg ctg ggc ccc ctg       1385
Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu           
215                 220                 225                 230           

cct tcc gag cag atg aag ctg ttc tac tct aac cca agg ttc cac ggc       1433
Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly           
                235                 240                 245               

ctg agg ttt cca gcc gtg aat cac ccc cag tct ctg gag cgc cgg tat       1481
Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr           
            250                 255                 260                   

ctg ggc atc ctg aac agc gtg ctg ctg gat ctg atg aag aat ctg ctg       1529
Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu           
        265                 270                 275                       

aag ctg gac cct gcc gat cgc tac ctg acc gag cag tgt ctg aat cac       1577
Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His           
    280                 285                 290                           

cca aca ttt cag acc cag aga ctg ctg gac agg agc ccc tcc cgc tct       1625
Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser           
295                 300                 305                 310           

gcc aag agg aag cct tat cac gtg gag agc tcc acc ctg agc aat cgc       1673
Ala Lys Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg           
                315                 320                 325               

aac cag gcc ggc aag tcc aca gcc ctg cag tct cac cac cgg agc aac       1721
Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn           
            330                 335                 340                   

tcc aag gac atc cag aat ctg agc gtg ggc ctg cca agg gca gac gag       1769
Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu           
        345                 350                 355                       

ggc ctg cct gcc aac gag tcc ttc ctg aat gga aac ctg gca gga gcc       1817
Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala           
    360                 365                 370                           

tct ctg agc cca ctg cac aca aag acc tac cag gcc tct agc cag cct       1865
Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro           
375                 380                 385                 390           

ggc tcc aca tct aag gac ctg acc aac aat aac atc cct cac ctg ctg       1913
Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu           
                395                 400                 405               

agc cca aag gag gcc aag tcc aag acc gag ttc gac ttt aat atc gat       1961
Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp           
            410                 415                 420                   

cca aag ccc agc gag ggc cca ggc aca aag tat ctg aag agc aac tcc       2009
Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser           
        425                 430                 435                       

aga tct cag cag aat agg cac tct ttc atg gag tcc tct cag agc aag       2057
Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys           
    440                 445                 450                           

gcc ggc acc ctg cag ccc aac gag aag cag agc agg cac tcc tac atc       2105
Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile           
455                 460                 465                 470           

gat acc atc cca cag agc tcc cgc agc ccc tcc tat cgg aca aag gcc       2153
Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala           
                475                 480                 485               

aag agc cac ggc gcc ctg tct gac agc aag tcc gtg tct aat ctg tcc       2201
Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser           
            490                 495                 500                   

gag gca aga gca cag atc gca gag cca agc acc tcc agg tac ttt ccc       2249
Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro           
        505                 510                 515                       

tct tcc tgt ctg gac ctg aac tct cca aca agc cct aca cca acc aga       2297
Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg           
    520                 525                 530                           

cac agc gat aca agg acc ctg ctg tct ccc agc ggc aga aat aac agg       2345
His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg           
535                 540                 545                 550           

aac gag ggc acc ctg gat agc aga agg acc aca acc aga cac tcc aag       2393
Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys           
                555                 560                 565               

aca atg gag gag ctg aag ctg ccc gag cac atg gac tcc tct cac tcc       2441
Thr Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser           
            570                 575                 580                   

cac tct ctg agc gcc cct cac gag tcc ttc tct tac ggc ctg ggc tat       2489
His Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr           
        585                 590                 595                       

acc agc cct ttt agc tcc cag cag cgc cca cac agg cac tcc atg tac       2537
Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr           
    600                 605                 610                           

gtg aca aga gac aag gtg agg gcc aag ggc ctg gac ggc agc ctg tcc       2585
Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser           
615                 620                 625                 630           

atc gga cag gga atg gca gca agg gca aat agc ctg cag ctg ctg tcc       2633
Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser           
                635                 640                 645               

cca cag cct gga gag cag ctg cca cca gag atg acc gtg gcc aga tct       2681
Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser           
            650                 655                 660                   

agc gtg aag gag aca agc agg gag ggc acc tcc tct ttc cac aca aga       2729
Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg           
        665                 670                 675                       

cag aag agc gag ggc ggc gtg tat cac gac cca cac tcc gac gac gga       2777
Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly           
    680                 685                 690                           

acc gca ccc aag gag aac agg cac ctg tac aac gat cca gtg ccc cgc       2825
Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg           
695                 700                 705                 710           

cgg gtg ggc tct ttc tat cgg gtg cct agc cca cgg ccc gac aac tcc       2873
Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser           
                715                 720                 725               

ttt cac gag aat aac gtg tct acc aga gtg agc tcc ctg cct agc gag       2921
Phe His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu           
            730                 735                 740                   

tct agc tcc ggc aca aac cac tcc aag agg cag cca gcc ttt gat ccc       2969
Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro           
        745                 750                 755                       

tgg aag tct cct gag aat atc tct cac agc gag cag ctg aag gag aag       3017
Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys           
    760                 765                 770                           

gag aag cag ggc ttc ttt cgc agc atg aag aag aag aag aag aag agc       3065
Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser           
775                 780                 785                 790           

cag aca acc gac agc acc aac ggc gag aat cct agc atc aag aag tcc       3113
Gln Thr Thr Asp Ser Thr Asn Gly Glu Asn Pro Ser Ile Lys Lys Ser           
                795                 800                 805               

ctg ttc cca ctg ttt aac tcc aag aat cac ctg aag cac tct agc tcc       3161
Leu Phe Pro Leu Phe Asn Ser Lys Asn His Leu Lys His Ser Ser Ser           
            810                 815                 820                   

ctg aag aag ctg ccc gtg gtg aca cct cca atg gtg ccc aat tcc gac       3209
Leu Lys Lys Leu Pro Val Val Thr Pro Pro Met Val Pro Asn Ser Asp           
        825                 830                 835                       

tct cct gat ctg ctg acc ctg cag aag agc atc cac agc gcc tcc aca       3257
Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr           
    840                 845                 850                           

cca tct agc aga ccc aag gag tgg agg cca gag aag atc tcc gat ctg       3305
Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu           
855                 860                 865                 870           

cag acc cag tcc cag ccc ctg aag tct ctg cgg aag ctg ctg cac ctg       3353
Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu           
                875                 880                 885               

tcc tct gcc agc aac cac cct gca agc tcc gac cct agg ttc cag cca       3401
Ser Ser Ala Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro           
            890                 895                 900                   

ctg aca gcc cag cag acc aag aac tct ttt agc gag atc aga atc cac       3449
Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His           
        905                 910                 915                       

cca ctg tcc cag gcc tct gga ggc tct agc aac atc cgc cag gag cct       3497
Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro           
    920                 925                 930                           

gcc cca aag ggc cgg cca gcc ctg cag ctg cca gga cag atg gac ccc       3545
Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro           
935                 940                 945                 950           

ggc tgg cac gtg tcc tct gtg aca aga tcc gcc acc gag gga cca tcc       3593
Gly Trp His Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser           
                955                 960                 965               

tac tct gag cag ctg gga gca aag tct gga cca aac gga cac cct tat       3641
Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr           
            970                 975                 980                   

aac agg acc aat aga tcc agg atg cct aat ctg aac gac ctg aag gag       3689
Asn Arg Thr Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu           
        985                 990                 995                       

aca gcc  ctg tga tag aagcttatcg ataatcaacc tctggattac aaaatttgtg      3744
Thr Ala  Leu                                                              
    1000                                                                  

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     3804

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     3864

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     3924

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     3984

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     4044

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     4104

cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg     4164

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     4224

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     4284

ccctttgggc cgcctccccg catcgatacc gtcgatcgag gccgcttcga gcagacatga     4344

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     4404

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     4464

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggagatg tgggaggttt     4524

tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga taaggatctt cctagagcat     4584

ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg     4644

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc     4704

gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4757


<210>  6
<211>  1001
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  6

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Thr Asp Ser Thr Asn Gly Glu Asn 
785                 790                 795                 800 


Pro Ser Ile Lys Lys Ser Leu Phe Pro Leu Phe Asn Ser Lys Asn His 
                805                 810                 815     


Leu Lys His Ser Ser Ser Leu Lys Lys Leu Pro Val Val Thr Pro Pro 
            820                 825                 830         


Met Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser 
        835                 840                 845             


Ile His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro 
    850                 855                 860                 


Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu 
865                 870                 875                 880 


Arg Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser Ser 
                885                 890                 895     


Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe 
            900                 905                 910         


Ser Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser 
        915                 920                 925             


Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu 
    930                 935                 940                 


Pro Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg Ser 
945                 950                 955                 960 


Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly 
                965                 970                 975     


Pro Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Lys Glu Thr Ala  Leu 
        995                 1000     


<210>  7
<211>  4583
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  promoter
<222>  (213)..(678)
<223>  hSynapsin

<220>
<221>  misc_feature
<222>  (690)..(695)
<223>  Kozak

<220>
<221>  CDS
<222>  (696)..(3530)
<223>  hCDKL5-3GS

<220>
<221>  misc_feature
<222>  (3545)..(4132)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (4150)..(4388)
<223>  SV40 polyA

<220>
<221>  misc_feature
<222>  (4416)..(4454)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  repeat_region
<222>  (4454)..(4583)
<223>  3'ITR

<400>  7
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gcctgcagag ggccctgcgt atgagtgcaa      240

gtgggtttta ggaccaggat gaggcggggt gggggtgcct acctgacgac cgaccccgac      300

ccactggaca agcacccaac ccccattccc caaattgcgc atcccctatc agagaggggg      360

aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag cttcagcacc gcggacagtg      420

ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca gcactgaagg cgcgctgacg      480

tcactcgccg gtcccccgca aactcccctt cccggccacc ttggtcgcgt ccgcgccgcc      540

gccggcccag ccggaccgca ccacgcgagg cgcgagatag gggggcacgg gcgcgaccat      600

ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg cggtgggcag cggaggagtc      660

gtgtcgtgcc tgagagcgca gtcgaattcg ccacc atg aag atc ccc aat atc         713
                                       Met Lys Ile Pro Asn Ile            
                                       1               5                  

ggc aac gtg atg aat aag ttc gag atc ctg gga gtg gtg gga gag gga        761
Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly           
            10                  15                  20                    

gca tac gga gtg gtg ctg aag tgc cgg cac aag gag aca cac gag atc        809
Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile           
        25                  30                  35                        

gtg gcc atc aag aag ttt aag gat agc gag gag aat gag gag gtg aag        857
Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys           
    40                  45                  50                            

gag aca acc ctg agg gag ctg aag atg ctg cgc aca ctg aag cag gag        905
Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu           
55                  60                  65                  70            

aac atc gtg gag ctg aag gag gcc ttc cgg aga agg ggc aag ctg tac        953
Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr           
                75                  80                  85                

ctg gtg ttt gag tac gtg gag aag aac atg ctg gag ctg ctg gag gag       1001
Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu           
            90                  95                  100                   

atg cct aat ggc gtg ccc cct gag aag gtg aag agc tac atc tat cag       1049
Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln           
        105                 110                 115                       

ctg atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac agg       1097
Leu Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg           
    120                 125                 130                           

gat atc aag cca gag aac ctg ctg atc agc cac aat gac gtg ctg aag       1145
Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys           
135                 140                 145                 150           

ctg tgc gat ttc ggc ttt gcc cgc aac ctg tcc gag ggc aac aac gcc       1193
Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala           
                155                 160                 165               

aat tac aca gag tac gtg gca acc agg tgg tac cgg tcc cca gag ctg       1241
Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu           
            170                 175                 180                   

ctg ctg gga gca cca tac ggc aag agc gtg gac atg tgg tcc gtg ggc       1289
Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly           
        185                 190                 195                       

tgc atc ctg ggc gag ctg tct gac ggc cag cct ctg ttc cca ggc gag       1337
Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu           
    200                 205                 210                           

agc gag atc gat cag ctg ttt acc atc cag aag gtg ctg ggc cct ctg       1385
Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu           
215                 220                 225                 230           

cca agc gag cag atg aag ctg ttc tac tcc aac cct agg ttc cac ggc       1433
Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly           
                235                 240                 245               

ctg cgc ttt ccc gcc gtg aat cac cct cag agc ctg gag cgc cgg tat       1481
Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr           
            250                 255                 260                   

ctg ggc atc ctg aac tcc gtg ctg ctg gat ctg atg aag aat ctg ctg       1529
Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu           
        265                 270                 275                       

aag ctg gac ccc gcc gat agg tac ctg acc gag cag tgt ctg aac cac       1577
Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His           
    280                 285                 290                           

ccc aca ttc cag acc cag aga ctg ctg gac agg tcc cct tct cgc aat       1625
Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Asn           
295                 300                 305                 310           

cag gcc ggc aag tct aca gcc ctg cag agc cac cac agg agc aac tcc       1673
Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser           
                315                 320                 325               

aag gac atc cag aat ctg agc gtg ggc ctg cct agg gca gac gag ggc       1721
Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly           
            330                 335                 340                   

ctg cca gca aac gag tcc ttt ctg aat gga aac ctg gca gga gcc tct       1769
Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser           
        345                 350                 355                       

ctg agc cca ctg cac aca aag acc tac cag gcc agc tcc cag cca ggc       1817
Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly           
    360                 365                 370                           

tcc aca tct aag gat ctg acc aac aat aac atc cca cac ctg ctg tct       1865
Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser           
375                 380                 385                 390           

ccc aag gag gcc aag agc aag acc gag ttc gac ttt aat atc gat ccc       1913
Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro           
                395                 400                 405               

aag cct agc gag ggc cca ggc aca aag tat ctg aag agc aac tcc cgg       1961
Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg           
            410                 415                 420                   

agc cag cag aat aga cac tcc ttc atg gag tct agc cag tct aag gcc       2009
Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala           
        425                 430                 435                       

ggc acc ctg cag ccc aac gag aag cag agc cgc cac tcc tac atc gat       2057
Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp           
    440                 445                 450                           

acc atc ccc cag tcc tct agg agc cct tcc tat cgc aca aag gcc aag       2105
Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys           
455                 460                 465                 470           

agc cac ggc gcc ctg tct gac agc aag tcc gtg tct aat ctg tcc gag       2153
Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu           
                475                 480                 485               

gca agg gca cag atc gca gag ccc agc acc tcc aga tac ttt cct agc       2201
Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser           
            490                 495                 500                   

tcc tgt ctg gac ctg aac tct cca aca agc cca aca ccc acc cgg cac       2249
Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His           
        505                 510                 515                       

agc gat aca aga acc ctg ctg tct ccc agc ggc aga aat aac agg aac       2297
Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn           
    520                 525                 530                           

gag ggc acc ctg gat tct aga agg acc aca acc cgg cac agc aag aca       2345
Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr           
535                 540                 545                 550           

atg gag gag ctg aag ctg ccc gag cac atg gac tct agc cac tcc cac       2393
Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His           
                555                 560                 565               

tct ctg agc gcc cct cac gag tcc ttc tct tac ggc ctg ggc tat acc       2441
Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr           
            570                 575                 580                   

tcc cca ttt tcc tct caa cag cgc ccc cac cgg cac tct atg tac gtg       2489
Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val           
        585                 590                 595                       

aca cgg gac aag gtg aga gcc aag ggc ctg gac ggc agc ctg tcc atc       2537
Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile           
    600                 605                 610                           

gga cag gga atg gca gca aga gca aac tcc ctg cag ctg ctg tct cct       2585
Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro           
615                 620                 625                 630           

cag cca gga gag cag ctg cca cca gag atg acc gtg gca cgg agc tcc       2633
Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser           
                635                 640                 645               

gtg aag gag aca agc aga gag ggc acc tct agc ttc cac aca cgg cag       2681
Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln           
            650                 655                 660                   

aag tcc gag ggc ggc gtg tat cac gac cct cac tct gac gac ggc acc       2729
Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr           
        665                 670                 675                       

gcc cca aag gag aac aga cac ctg tac aac gat cca gtg cct agg agg       2777
Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg Arg           
    680                 685                 690                           

gtg ggc tcc ttc tat cgg gtg cca tct ccc cgc cct gac aat agc ttt       2825
Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser Phe           
695                 700                 705                 710           

cac gag aat aac gtg tcc acc cgg gtg tcc tct ctg ccc tct gag agc       2873
His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu Ser           
                715                 720                 725               

tcc tct ggc aca aac cac tct aag aga cag ccc gcc ttt gac cct tgg       2921
Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro Trp           
            730                 735                 740                   

aag agc cca gag aat atc tct cac agc gag cag ctg aag gag aag gag       2969
Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys Glu           
        745                 750                 755                       

aag cag ggc ttc ttt agg agc atg aag aag aag aag aag aag agc cag       3017
Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser Gln           
    760                 765                 770                           

acc gtg cct aac tcc gac tct ccc gat ctg ctg acc ctg cag aag agc       3065
Thr Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser           
775                 780                 785                 790           

atc cac agc gcc tcc aca cca agc tcc cgg cct aag gag tgg cgg ccc       3113
Ile His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro           
                795                 800                 805               

gag aag atc tcc gat ctg cag acc cag agc cag cca ctg aag tcc ctg       3161
Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu           
            810                 815                 820                   

cgc aag ctg ctg cac ctg tct agc gcc agc aac cac cct gcc tcc tct       3209
Arg Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser Ser           
        825                 830                 835                       

gac cca agg ttc cag ccc ctg aca gcc cag cag acc aag aac tct ttt       3257
Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe           
    840                 845                 850                           

agc gag atc cgc atc cac cca ctg tcc caa gcc tct gga ggc agc tcc       3305
Ser Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser           
855                 860                 865                 870           

aac atc agg cag gag cca gca cca aag ggc cgc ccc gcc ctg cag ctg       3353
Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu           
                875                 880                 885               

cct gga cag atg gac ccc gga tgg cac gtg tct agc gtg aca cgg tcc       3401
Pro Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg Ser           
            890                 895                 900                   

gcc acc gag gga cca tcc tac tct gag cag ctg gga gca aag agc gga       3449
Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly           
        905                 910                 915                       

cct aac gga cac cca tat aac aga acc aat aga tcc agg atg cct aat       3497
Pro Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro Asn           
    920                 925                 930                           

ctg aac gac ctg aag gag aca gcc ctg tga tag aagcttatcg ataatcaacc     3550
Leu Asn Asp Leu Lys Glu Thr Ala Leu                                       
935                 940                                                   

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     3610

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     3670

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     3730

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     3790

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     3850

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     3910

tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt     3970

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     4030

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     4090

ccctcagacg agtcggatct ccctttgggc cgcctccccg catcgatacc gtcgatcgag     4150

gccgcttcga gcagacatga taagatacat tgatgagttt ggacaaacca caactagaat     4210

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     4270

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     4330

gggggagatg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga     4390

taaggatctt cctagagcat ggctacgtag ataagtagca tggcgggtta atcattaact     4450

acaaggaacc cctagtgatg gagttggcca ctccctctct gcgcgctcgc tcgctcactg     4510

aggccgggcg accaaaggtc gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg     4570

agcgagcgcg cag                                                        4583


<210>  8
<211>  943
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  8

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser 
305                 310                 315                 320 


His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu 
                325                 330                 335     


Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly 
            340                 345                 350         


Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln 
        355                 360                 365             


Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn 
    370                 375                 380                 


Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe 
385                 390                 395                 400 


Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr 
                405                 410                 415     


Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu 
            420                 425                 430         


Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser 
        435                 440                 445             


Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser 
    450                 455                 460                 


Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser 
465                 470                 475                 480 


Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr 
                485                 490                 495     


Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser 
            500                 505                 510         


Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser 
        515                 520                 525             


Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr 
    530                 535                 540                 


Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His Met 
545                 550                 555                 560 


Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe Ser 
                565                 570                 575     


Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His 
            580                 585                 590         


Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu 
        595                 600                 605             


Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser 
    610                 615                 620                 


Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met 
625                 630                 635                 640 


Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser 
                645                 650                 655     


Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro 
            660                 665                 670         


His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn 
        675                 680                 685             


Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro 
    690                 695                 700                 


Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val Ser 
705                 710                 715                 720 


Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln 
                725                 730                 735     


Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu 
            740                 745                 750         


Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys 
        755                 760                 765             


Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp Leu 
    770                 775                 780                 


Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser Arg 
785                 790                 795                 800 


Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser 
                805                 810                 815     


Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala Ser 
            820                 825                 830         


Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln 
        835                 840                 845             


Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser Gln 
    850                 855                 860                 


Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly 
865                 870                 875                 880 


Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His Val 
                885                 890                 895     


Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln 
            900                 905                 910         


Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr Asn 
        915                 920                 925             


Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
    930                 935                 940             


<210>  9
<211>  4706
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression Cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5'ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  promoter
<222>  (213)..(678)
<223>  hSynapsin

<220>
<221>  misc_feature
<222>  (690)..(695)
<223>  Kozak

<220>
<221>  CDS
<222>  (696)..(3653)
<223>  hCDKL5-4GS

<220>
<221>  misc_feature
<222>  (3668)..(4255)
<223>  WRPE

<220>
<221>  polyA_signal
<222>  (4273)..(4511)
<223>  SV40 PolyA

<220>
<221>  misc_feature
<222>  (4539)..(4577)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  repeat_region
<222>  (4577)..(4706)
<223>  3'ITR

<400>  9
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gcctgcagag ggccctgcgt atgagtgcaa      240

gtgggtttta ggaccaggat gaggcggggt gggggtgcct acctgacgac cgaccccgac      300

ccactggaca agcacccaac ccccattccc caaattgcgc atcccctatc agagaggggg      360

aggggaaaca ggatgcggcg aggcgcgtgc gcactgccag cttcagcacc gcggacagtg      420

ccttcgcccc cgcctggcgg cgcgcgccac cgccgcctca gcactgaagg cgcgctgacg      480

tcactcgccg gtcccccgca aactcccctt cccggccacc ttggtcgcgt ccgcgccgcc      540

gccggcccag ccggaccgca ccacgcgagg cgcgagatag gggggcacgg gcgcgaccat      600

ctgcgctgcg gcgccggcga ctcagcgctg cctcagtctg cggtgggcag cggaggagtc      660

gtgtcgtgcc tgagagcgca gtcgaattcg ccacc atg aag atc ccc aat atc         713
                                       Met Lys Ile Pro Asn Ile            
                                       1               5                  

ggc aac gtg atg aat aag ttc gag atc ctg gga gtg gtg gga gag gga        761
Gly Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly           
            10                  15                  20                    

gca tac gga gtg gtg ctg aag tgc cgg cac aag gag aca cac gag atc        809
Ala Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile           
        25                  30                  35                        

gtg gcc atc aag aag ttt aag gat agc gag gag aat gag gag gtg aag        857
Val Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys           
    40                  45                  50                            

gag aca acc ctg agg gag ctg aag atg ctg cgc aca ctg aag cag gag        905
Glu Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu           
55                  60                  65                  70            

aac atc gtg gag ctg aag gag gcc ttc cgg aga agg ggc aag ctg tac        953
Asn Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr           
                75                  80                  85                

ctg gtg ttt gag tac gtg gag aag aac atg ctg gag ctg ctg gag gag       1001
Leu Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu           
            90                  95                  100                   

atg cca aat ggc gtg ccc cct gag aag gtg aag tcc tac atc tat cag       1049
Met Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln           
        105                 110                 115                       

ctg atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac agg       1097
Leu Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg           
    120                 125                 130                           

gat atc aag ccc gag aac ctg ctg atc tcc cac aat gac gtg ctg aag       1145
Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys           
135                 140                 145                 150           

ctg tgc gat ttc ggc ttt gcc cgc aac ctg agc gag ggc aac aac gcc       1193
Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala           
                155                 160                 165               

aat tac aca gag tac gtg gca acc agg tgg tac cgg agc cct gag ctg       1241
Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu           
            170                 175                 180                   

ctg ctg gga gca cca tac ggc aag tct gtg gac atg tgg agc gtg ggc       1289
Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly           
        185                 190                 195                       

tgc atc ctg gga gag ctg tcc gac gga cag cca ctg ttc cct ggc gag       1337
Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu           
    200                 205                 210                           

tct gag atc gat cag ctg ttt acc atc cag aag gtg ctg ggc ccc ctg       1385
Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu           
215                 220                 225                 230           

cct tcc gag cag atg aag ctg ttc tac tct aac cct agg ttc cac ggc       1433
Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly           
                235                 240                 245               

ctg cgc ttt cca gcc gtg aat cac ccc cag tct ctg gag cgc cgg tat       1481
Leu Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr           
            250                 255                 260                   

ctg ggc atc ctg aac agc gtg ctg ctg gat ctg atg aag aat ctg ctg       1529
Leu Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu           
        265                 270                 275                       

aag ctg gac ccc gcc gat agg tac ctg acc gag cag tgt ctg aac cac       1577
Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His           
    280                 285                 290                           

cct aca ttc cag acc cag aga ctg ctg gac agg tcc cca tct cgc aat       1625
Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Asn           
295                 300                 305                 310           

cag gcc ggc aag tcc aca gcc ctg cag tct cac cac agg agc aac tcc       1673
Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser           
                315                 320                 325               

aag gac atc cag aat ctg tcc gtg ggc ctg cca agg gca gac gag ggc       1721
Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly           
            330                 335                 340                   

ctg cct gcc aac gag agc ttt ctg aat gga aac ctg gca gga gcc tct       1769
Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser           
        345                 350                 355                       

ctg agc cca ctg cac aca aag acc tac cag gcc agc tcc cag cct ggc       1817
Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly           
    360                 365                 370                           

tcc aca tct aag gac ctg acc aac aat aac atc cct cac ctg ctg agc       1865
Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser           
375                 380                 385                 390           

cca aag gag gcc aag tcc aag acc gag ttc gac ttt aat atc gat cca       1913
Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro           
                395                 400                 405               

aag cca tcc gag gga cca gga aca aag tat ctg aag agc aac tcc cgg       1961
Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg           
            410                 415                 420                   

agc cag cag aat aga cac tct ttc atg gag tct agc cag agc aag gcc       2009
Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala           
        425                 430                 435                       

ggc acc ctg cag cct aac gag aag cag agc cgc cac tcc tac atc gat       2057
Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp           
    440                 445                 450                           

acc atc cca cag tcc tct agg agc ccc tcc tat cgc aca aag gcc aag       2105
Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys           
455                 460                 465                 470           

tcc cac ggc gcc ctg tct gac agc aag tcc gtg tct aat ctg agc gag       2153
Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu           
                475                 480                 485               

gca agg gca cag atc gca gag cca agc acc tcc aga tac ttt ccc agc       2201
Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser           
            490                 495                 500                   

tcc tgt ctg gac ctg aac tct ccc aca agc cct aca cca acc cgg cac       2249
Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His           
        505                 510                 515                       

agc gat aca aga acc ctg ctg tct cct agc ggc aga aat aac agg aac       2297
Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn           
    520                 525                 530                           

gag ggc acc ctg gat agc aga agg acc aca acc agg cac tcc aag aca       2345
Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr           
535                 540                 545                 550           

atg gag gag ctg aag ctg cct gag cac atg gac tct agc cac tcc cac       2393
Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His           
                555                 560                 565               

tct ctg agc gcc cca cac gag tcc ttc tct tac ggc ctg ggc tat acc       2441
Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr           
            570                 575                 580                   

agc cct ttt tcc tct caa caa cgc cca cac cgg cac tcc atg tac gtg       2489
Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val           
        585                 590                 595                       

aca cgg gac aag gtg aga gcc aag ggc ctg gac ggc agc ctg tcc atc       2537
Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile           
    600                 605                 610                           

gga cag gga atg gca gca agg gca aat agc ctg cag ctg ctg tcc cca       2585
Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro           
615                 620                 625                 630           

cag cct gga gag cag ctg cca cca gag atg acc gtg gca cgg agc tcc       2633
Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser           
                635                 640                 645               

gtg aag gag aca agc aga gag ggc acc tct agc ttc cac aca cgg cag       2681
Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln           
            650                 655                 660                   

aag agc gag ggc ggc gtg tat cac gac cca cac tcc gac gac gga acc       2729
Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr           
        665                 670                 675                       

gca cct aag gag aac aga cac ctg tac aac gat cca gtg ccc cgc cgg       2777
Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg Arg           
    680                 685                 690                           

gtg ggc tct ttc tat cgg gtg cct agc cca cgc ccc gac aac tcc ttt       2825
Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser Phe           
695                 700                 705                 710           

cac gag aat aac gtg tct acc cgg gtg tcc tct ctg ccc agc gag agc       2873
His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu Ser           
                715                 720                 725               

tcc tct ggc aca aac cac tcc aag aga cag cca gcc ttt gat ccc tgg       2921
Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro Trp           
            730                 735                 740                   

aag tct cct gag aat atc tct cac agc gag cag ctg aag gag aag gag       2969
Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys Glu           
        745                 750                 755                       

aag cag ggc ttc ttt cgg tcc atg aag aag aag aag aag aag agc cag       3017
Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser Gln           
    760                 765                 770                           

aca acc gac agc acc aac ggc gag aat cca agc atc aag aag tcc ctg       3065
Thr Thr Asp Ser Thr Asn Gly Glu Asn Pro Ser Ile Lys Lys Ser Leu           
775                 780                 785                 790           

ttc ccc ctg ttt aac agc aag aat cac ctg aag cac agc tcc tct ctg       3113
Phe Pro Leu Phe Asn Ser Lys Asn His Leu Lys His Ser Ser Ser Leu           
                795                 800                 805               

aag aag ctg ccc gtg gtg aca cct cca atg gtg ccc aat tcc gac tct       3161
Lys Lys Leu Pro Val Val Thr Pro Pro Met Val Pro Asn Ser Asp Ser           
            810                 815                 820                   

cct gat ctg ctg acc ctg cag aag tcc atc cac agc gcc tcc aca cca       3209
Pro Asp Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro           
        825                 830                 835                       

agc tcc cgg ccc aag gag tgg cgg ccc gag aag atc agc gat ctg cag       3257
Ser Ser Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln           
    840                 845                 850                           

acc cag tcc cag ccc ctg aag tct ctg aga aag ctg ctg cac ctg tct       3305
Thr Gln Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser           
855                 860                 865                 870           

agc gcc tcc aac cac cca gcc tcc tct gac cct cgg ttc cag cca ctg       3353
Ser Ala Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu           
                875                 880                 885               

aca gcc cag cag acc aag aac tct ttt agc gag atc cgc atc cac cca       3401
Thr Ala Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro           
            890                 895                 900                   

ctg tcc caa gcc tct gga ggc agc tcc aac atc agg cag gag cct gcc       3449
Leu Ser Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala           
        905                 910                 915                       

cca aag ggc cgc cca gcc ctg cag ctg cca gga cag atg gac ccc ggc       3497
Pro Lys Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly           
    920                 925                 930                           

tgg cac gtg tct agc gtg aca cgg agc gcc acc gag gga cct tcc tac       3545
Trp His Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr           
935                 940                 945                 950           

tct gag cag ctg gga gca aag tct gga cca aac gga cac cct tat aac       3593
Ser Glu Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn           
                955                 960                 965               

aga acc aat aga agc agg atg cca aat ctg aac gac ctg aag gag aca       3641
Arg Thr Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr           
            970                 975                 980                   

gcc ctg tga tag aagcttatcg ataatcaacc tctggattac aaaatttgtg           3693
Ala Leu                                                                   
                                                                          

aaagattgac tggtattctt aactatgttg ctccttttac gctatgtgga tacgctgctt     3753

taatgccttt gtatcatgct attgcttccc gtatggcttt cattttctcc tccttgtata     3813

aatcctggtt gctgtctctt tatgaggagt tgtggcccgt tgtcaggcaa cgtggcgtgg     3873

tgtgcactgt gtttgctgac gcaaccccca ctggttgggg cattgccacc acctgtcagc     3933

tcctttccgg gactttcgct ttccccctcc ctattgccac ggcggaactc atcgccgcct     3993

gccttgcccg ctgctggaca ggggctcggc tgttgggcac tgacaattcc gtggtgttgt     4053

cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt tgccacctgg attctgcgcg     4113

ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc ggaccttcct tcccgcggcc     4173

tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg ccctcagacg agtcggatct     4233

ccctttgggc cgcctccccg catcgatacc gtcgatcgag gccgcttcga gcagacatga     4293

taagatacat tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta     4353

tttgtgaaat ttgtgatgct attgctttat ttgtaaccat tataagctgc aataaacaag     4413

ttaacaacaa caattgcatt cattttatgt ttcaggttca gggggagatg tgggaggttt     4473

tttaaagcaa gtaaaacctc tacaaatgtg gtaaaatcga taaggatctt cctagagcat     4533

ggctacgtag ataagtagca tggcgggtta atcattaact acaaggaacc cctagtgatg     4593

gagttggcca ctccctctct gcgcgctcgc tcgctcactg aggccgggcg accaaaggtc     4653

gcccgacgcc cgggctttgc ccgggcggcc tcagtgagcg agcgagcgcg cag            4706


<210>  10
<211>  984
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  10

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser 
305                 310                 315                 320 


His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly Leu 
                325                 330                 335     


Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly 
            340                 345                 350         


Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr Gln 
        355                 360                 365             


Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn 
    370                 375                 380                 


Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe 
385                 390                 395                 400 


Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr 
                405                 410                 415     


Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met Glu 
            420                 425                 430         


Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser 
        435                 440                 445             


Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser 
    450                 455                 460                 


Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys Ser 
465                 470                 475                 480 


Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr 
                485                 490                 495     


Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser 
            500                 505                 510         


Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser 
        515                 520                 525             


Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr 
    530                 535                 540                 


Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His Met 
545                 550                 555                 560 


Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe Ser 
                565                 570                 575     


Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro His 
            580                 585                 590         


Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly Leu 
        595                 600                 605             


Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn Ser 
    610                 615                 620                 


Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu Met 
625                 630                 635                 640 


Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr Ser 
                645                 650                 655     


Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp Pro 
            660                 665                 670         


His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr Asn 
        675                 680                 685             


Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser Pro 
    690                 695                 700                 


Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val Ser 
705                 710                 715                 720 


Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg Gln 
                725                 730                 735     


Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser Glu 
            740                 745                 750         


Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys Lys 
        755                 760                 765             


Lys Lys Lys Lys Ser Gln Thr Thr Asp Ser Thr Asn Gly Glu Asn Pro 
    770                 775                 780                 


Ser Ile Lys Lys Ser Leu Phe Pro Leu Phe Asn Ser Lys Asn His Leu 
785                 790                 795                 800 


Lys His Ser Ser Ser Leu Lys Lys Leu Pro Val Val Thr Pro Pro Met 
                805                 810                 815     


Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser Ile 
            820                 825                 830         


His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro Glu 
        835                 840                 845             


Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu Arg 
    850                 855                 860                 


Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser Ser Asp 
865                 870                 875                 880 


Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe Ser 
                885                 890                 895     


Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser Asn 
            900                 905                 910         


Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu Pro 
        915                 920                 925             


Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg Ser Ala 
    930                 935                 940                 


Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly Pro 
945                 950                 955                 960 


Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro Asn Leu 
                965                 970                 975     


Asn Asp Leu Lys Glu Thr Ala Leu 
            980                 


<210>  11
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  targeting site

<400>  11
agtgaattct accagtgcca ta                                                22


<210>  12
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  targeting site

<400>  12
agcaaaaatg tgctagtgcc aaa                                               23


<210>  13
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  targeting sequence

<400>  13
agtgtgagtt ctaccattgc caaa                                              24


<210>  14
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  targeting sequence

<400>  14
agggattcct gggaaaactg gac                                               23


<210>  15
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  spacer

<400>  15
atgacttaaa ccaggt                                                       16


<210>  16
<211>  3430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transcript variant

<400>  16
gggggagttg gaggaggaag accctacagg aagttgagct gtactctcca acaggcgagc       60

acatggtcgt ctcctctctc ccttcaggga gtcatttaat acttcatgat tagaacaaat      120

atgtgaaagt tcccaccaac cagtgagaat ttcttccttc agacggtttt ggatcttact      180

gcacagcttt ctgagaagtt cttttggtgc catgttttgt ggcttgcatc aaaagaggag      240

tttgtcttca tgaagattcc taacattggt aatgtgatga ataaatttga gatccttggg      300

gttgtaggtg aaggagccta tggagttgta cttaaatgca gacacaagga aacacatgaa      360

attgtggcga tcaagaaatt caaggacagt gaagaaaatg aagaagtcaa agaaacgact      420

ttacgagagc ttaaaatgct tcggactctc aagcaggaaa acattgtgga gttgaaggaa      480

gcatttcgtc ggaggggaaa gttgtacttg gtgtttgagt atgttgaaaa aaatatgctc      540

gaattgctgg aagaaatgcc aaatggagtt ccacctgaga aagtaaaaag ctacatctat      600

cagctaatca aggctattca ctggtgccat aagaatgata ttgtccatcg agatataaaa      660

ccagaaaatc tcttaatcag ccacaatgat gtcctaaaac tgtgtgactt tggttttgct      720

cgtaatctgt cagaaggcaa taatgctaat tacacagagt acgttgccac cagatggtat      780

cggtccccag aactcttact tggcgctccc tatggaaagt ccgtggacat gtggtcggtg      840

ggctgtattc ttggggagct tagcgatgga cagcctttat ttcctggaga aagtgaaatt      900

gaccaacttt ttactattca gaaggtgcta ggaccacttc catctgagca gatgaagctt      960

ttctacagta atcctcgctt ccatgggctc cggtttccag ctgttaacca tcctcagtcc     1020

ttggaaagaa gataccttgg aattttgaat agtgttctac ttgacctaat gaagaattta     1080

ctgaagttgg acccagctga cagatacttg acagaacagt gtttgaatca ccctacattt     1140

caaacccaga gacttctgga tcgttctcct tcaaggtcag caaaaagaaa accttaccat     1200

gtggaaagca gcacattgtc taatagaaac caagccggca aaagtactgc tttgcagtct     1260

caccacagat ctaacagcaa ggacatccag aacctgagtg taggcctgcc ccgggctgac     1320

gaaggtctcc ctgccaatga aagcttccta aatggaaacc ttgctggagc tagtcttagt     1380

ccactgcaca ccaaaaccta ccaagcaagc agccagcctg ggtctaccag caaagatctc     1440

accaacaaca acataccaca ccttcttagc ccaaaagaag ccaagtcaaa aacagagttt     1500

gattttaata ttgacccaaa gccttcagaa ggcccaggga caaagtacct caagtcaaac     1560

agcagatctc agcagaaccg ccactcattc atggaaagct ctcaaagcaa agctgggaca     1620

ctgcagccca atgaaaagca gagtcggcat agctatattg acacaattcc ccagtcctct     1680

aggagtccct cctacaggac caaggccaaa agccatgggg cactgagtga ctccaagtct     1740

gtgagcaacc tttctgaagc cagggcccaa attgcggagc ccagtaccag taggtacttc     1800

ccatctagct gcttagactt gaattctccc accagcccaa cccccaccag acacagtgac     1860

acgagaactt tgctcagccc ttctggaaga aataaccgaa atgagggaac gctggactca     1920

cgtcgaacca caaccagaca ttctaagacg atggaggaat tgaagctgcc ggagcacatg     1980

gacagtagcc attcccattc actgtctgca cctcacgaat ctttttctta tggactgggc     2040

tacaccagcc ccttttcttc ccagcaacgt cctcataggc attctatgta tgtgacccgt     2100

gacaaagtga gagccaaggg cttggatgga agcttgagca tagggcaagg gatggcagct     2160

agagccaaca gcctgcaact cttgtcaccc cagcctggag aacagctccc tccagagatg     2220

actgtggcaa gatcttcggt caaagagacc tccagagaag gcacctcttc cttccataca     2280

cgccagaagt ctgagggtgg agtgtatcat gacccacact ctgatgatgg cacagccccc     2340

aaagaaaata gacacctata caatgatcct gtgccaagga gagttggtag cttttacaga     2400

gtgccatctc cacgtccaga caattctttc catgaaaata atgtgtcaac tagagtttct     2460

tctctaccat cagagagcag ttctggaacc aaccactcaa aaagacaacc agcattcgat     2520

ccatggaaaa gtcctgaaaa tattagtcat tcagagcaac tcaaggaaaa agagaagcaa     2580

ggatttttca ggtcaatgaa aaagaaaaag aagaaatctc aaacagtacc caattccgac     2640

agccctgatc ttctgacgtt gcagaaatcc attcattctg ctagcactcc aagcagcaga     2700

ccaaaggagt ggcgccccga gaagatctca gatctgcaga cccaaagcca gccattaaaa     2760

tcactgcgca agttgttaca tctctcttcg gcctcaaatc acccggcttc ctcagatccc     2820

cgcttccagc ccttaacagc tcaacaaacc aaaaattcct tctcagaaat tcggattcac     2880

cccctgagcc aggcctctgg cgggagcagc aacatccggc aggaacccgc accgaagggc     2940

aggccagccc tccagctgcc agacggtgga tgtgatggca gaagacagag acaccattct     3000

ggaccccaag atagacgctt catgttaagg acgacagaac aacaaggaga atacttctgc     3060

tgtggtgacc caaagaagcc tcacactccg tgcgtcccaa accgagccct tcatcgtcca     3120

atctccagtc ctgctcccta tccagtactc caggtccgag gcacttccat gtgcccgaca     3180

ctccaggtcc gaggcactga tgctttcagc tgcccaaccc agcaatccgg gttctctttc     3240

ttcgtgagac acgttatgag ggaagccctg attcacaggg cccaggtaaa ccaagctgcg     3300

ctcctgacat accatgagaa tgcggcactg acgggcaagt gacttctgca agcctgcggc     3360

tggtcccaat gccctgaatc acctctctca tggaagaacc aattaacacc aatgaatcaa     3420

ccattaaaaa                                                            3430


<210>  17
<211>  14572
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transcript variant

<400>  17
agttgtctct gccgctgggg aaggtaaagc ggcgacggcg tcctcaggag ctgtggggtc       60

ccctgctaga agtgggggac tcggcggggg agtcatttaa tacttcatga ttagaacaaa      120

tatgtgaaag ttcccaccaa ccagtgagaa tttcttcctt cagacggttt tggatcttac      180

tgcacagctt tctgagaagt tcttttggtg ccatgttttg tggcttgcat caaaagagga      240

gtttgtcttc atgaagattc ctaacattgg taatgtgatg aataaatttg agatccttgg      300

ggttgtaggt gaaggagcct atggagttgt acttaaatgc agacacaagg aaacacatga      360

aattgtggcg atcaagaaat tcaaggacag tgaagaaaat gaagaagtca aagaaacgac      420

tttacgagag cttaaaatgc ttcggactct caagcaggaa aacattgtgg agttgaagga      480

agcatttcgt cggaggggaa agttgtactt ggtgtttgag tatgttgaaa aaaatatgct      540

cgaattgctg gaagaaatgc caaatggagt tccacctgag aaagtaaaaa gctacatcta      600

tcagctaatc aaggctattc actggtgcca taagaatgat attgtccatc gagatataaa      660

accagaaaat ctcttaatca gccacaatga tgtcctaaaa ctgtgtgact ttggttttgc      720

tcgtaatctg tcagaaggca ataatgctaa ttacacagag tacgttgcca ccagatggta      780

tcggtcccca gaactcttac ttggcgctcc ctatggaaag tccgtggaca tgtggtcggt      840

gggctgtatt cttggggagc ttagcgatgg acagccttta tttcctggag aaagtgaaat      900

tgaccaactt tttactattc agaaggtgct aggaccactt ccatctgagc agatgaagct      960

tttctacagt aatcctcgct tccatgggct ccggtttcca gctgttaacc atcctcagtc     1020

cttggaaaga agataccttg gaattttgaa tagtgttcta cttgacctaa tgaagaattt     1080

actgaagttg gacccagctg acagatactt gacagaacag tgtttgaatc accctacatt     1140

tcaaacccag agacttctgg atcgttctcc ttcaaggtca gcaaaaagaa aaccttacca     1200

tgtggaaagc agcacattgt ctaatagaaa ccaagccggc aaaagtactg ctttgcagtc     1260

tcaccacaga tctaacagca aggacatcca gaacctgagt gtaggcctgc cccgggctga     1320

cgaaggtctc cctgccaatg aaagcttcct aaatggaaac cttgctggag ctagtcttag     1380

tccactgcac accaaaacct accaagcaag cagccagcct gggtctacca gcaaagatct     1440

caccaacaac aacataccac accttcttag cccaaaagaa gccaagtcaa aaacagagtt     1500

tgattttaat attgacccaa agccttcaga aggcccaggg acaaagtacc tcaagtcaaa     1560

cagcagatct cagcagaacc gccactcatt catggaaagc tctcaaagca aagctgggac     1620

actgcagccc aatgaaaagc agagtcggca tagctatatt gacacaattc cccagtcctc     1680

taggagtccc tcctacagga ccaaggccaa aagccatggg gcactgagtg actccaagtc     1740

tgtgagcaac ctttctgaag ccagggccca aattgcggag cccagtacca gtaggtactt     1800

cccatctagc tgcttagact tgaattctcc caccagccca acccccacca gacacagtga     1860

cacgagaact ttgctcagcc cttctggaag aaataaccga aatgagggaa cgctggactc     1920

acgtcgaacc acaaccagac attctaagac gatggaggaa ttgaagctgc cggagcacat     1980

ggacagtagc cattcccatt cactgtctgc acctcacgaa tctttttctt atggactggg     2040

ctacaccagc cccttttctt cccagcaacg tcctcatagg cattctatgt atgtgacccg     2100

tgacaaagtg agagccaagg gcttggatgg aagcttgagc atagggcaag ggatggcagc     2160

tagagccaac agcctgcaac tcttgtcacc ccagcctgga gaacagctcc ctccagagat     2220

gactgtggca agatcttcgg tcaaagagac ctccagagaa ggcacctctt ccttccatac     2280

acgccagaag tctgagggtg gagtgtatca tgacccacac tctgatgatg gcacagcccc     2340

caaagaaaat agacacctat acaatgatcc tgtgccaagg agagttggta gcttttacag     2400

agtgccatct ccacgtccag acaattcttt ccatgaaaat aatgtgtcaa ctagagtttc     2460

ttctctacca tcagagagca gttctggaac caaccactca aaaagacaac cagcattcga     2520

tccatggaaa agtcctgaaa atattagtca ttcagagcaa ctcaaggaaa aagagaagca     2580

aggatttttc aggtcaatga aaaagaaaaa gaagaaatct caaacagtac ccaattccga     2640

cagccctgat cttctgacgt tgcagaaatc cattcattct gctagcactc caagcagcag     2700

accaaaggag tggcgccccg agaagatctc agatctgcag acccaaagcc agccattaaa     2760

atcactgcgc aagttgttac atctctcttc ggcctcaaat cacccggctt cctcagatcc     2820

ccgcttccag cccttaacag ctcaacaaac caaaaattcc ttctcagaaa ttcggattca     2880

ccccctgagc caggcctctg gcgggagcag caacatccgg caggaacccg caccgaaggg     2940

caggccagcc ctccagctgc caggtcagat ggatcctggt tggcatgtgt cctctgtgac     3000

caggagtgcc acagagggcc cttcctactc tgaacagctg ggtgccaaaa gtgggccaaa     3060

tgggcacccc tataacagaa caaatcgctc acgaatgcca aatctgaatg atttaaaaga     3120

gacagccttg taatttgtgc tggtaggggg gaggggtgga cagacaagcc agtggggagg     3180

ggtgggaaag ggtgggctgg gcttggggca tgggccgggc caagtggtga gccaatattt     3240

tcagctttat gaaggtgtgt gcaatattgc atgtgttggg gccgttgagc tcctcgcggc     3300

cacaaatgct agtcagggat cttagagcca caggagttcc ttagggatcg ccactcccca     3360

caggtcttgt gtgagaatag atagagtgtg ccattgagga agaagaaatt cttgccagtt     3420

tctccccttt acattccagc tttagtgcaa tctctgttga acttgggaat gccaggatgt     3480

gtcctggcac tgcaagggat aggaaagtcg tgttgaccga tgcccttact acatattttt     3540

ttctgcctag agtaaatgtg gggtttattg taatccaaga gtatcccttt gaagggttag     3600

cagatgaact gtatgtctta aattgttttc taaacttcca tatttgatag gatttgtaac     3660

atttatttat aattaatatt gtactgttaa aatcatatct tttatgttat aatgtaaagt     3720

tattttgagc tgtttgaaac attgtgaagc agtgggacag ctacagtagt ttctataaaa     3780

actaaacagt aacatttata tattgcatca ggagtatttt attctatata taatatatat     3840

atatggtaaa tatctgtttt ataaatatat tcatttaaag aaagtatcgt tatgacacta     3900

tctgccatat ttttatacat ttgtgatatg aagtgagtat tatacttcta ctaaagggag     3960

ttgaattgtg gctacacgtg actgtaacag tatgaacctt gctcaacttt gaggccccag     4020

cagtagcctc tagacatgat ccttggtagc agacgagatg cagcatctct ttccaaacct     4080

gcaggggaag aaagtcagat aggccagtga gaattccagc aggcctggtt tccgtcctca     4140

cacacttggc tcctgtttgt gtccagggac gttacttgca cacaggggag aatagattga     4200

ggcgttactc gtgggtcttt gtagagagaa tgtgctcttc cacttagcat tagtgtagag     4260

cgtagaccaa agatttgcca gtgaacattc cttgttgtga gatcataaga ggtacctgtc     4320

tgcagatctt gcaaaccatc tctatgctcc tgaatattgt ccactgtccc ggagactctt     4380

ggctgatggg gtgtgagata tatgtgtggc atttctattt ctgaatgcct tttttgctat     4440

tgctctctcc aataccatat ttaaaaggct cctggagcaa ttccagatag ataaaaaatt     4500

actctatcca tttttttctt cctggggctg tccacttatg acaagatttt catgcacacc     4560

tgttacgcac acaaccccca tcagaacagg acctatcttc ccctcatctg atctctttca     4620

gctcccaagt tactcccaag tatcatcaaa ccctttggcc atcaagtgtt atcctcccat     4680

gcctctgggt catccttgag ggaagtcacc tcagcaccat catctatcag tagtagtaga     4740

tttttggaat tagtctctga gcaataatac ttttaaaggt ccctcccacc cctcaaagag     4800

ataacttctc agtatttatt acttgtcctc aaattctgag tgtcagcccc tgcatcaagt     4860

cagctatgat caaaatgtgc tgttactgtt aaccctcccc cgagattttg agaatcatag     4920

ctctgatgat tatgaagatt ataaagacta aggtcctagt ttccctgaag cttaaattgt     4980

gcacatattg catttttata taaatactat aatgtgtatt gattatatag ataggtcatt     5040

ttaaggtgct ttttatttaa ttttaatgag tgtaataggc actaaaatga aactcgactg     5100

ggtactatta ctgaaaaaat ttgactcaaa ccaatagttt tgcatgctct ttagttcttt     5160

ttctgtctta cttctttcac cagttcagta ctgtttgggt agctctgaat tctggctttt     5220

ccaggcagct gcttgatgat acaaatgagg tggaccatca gcagttttgc ctggacacta     5280

atgactctaa aagggtgtgt atttaactct tctttttcat actagatctc taccttgtat     5340

tccccccttg caaaccagaa actacacttt ttttctctgg aaagacttct cactgtgcta     5400

tgcgcttagg aactgcacgg tcccgttgcc atgctgtggc attcgaggct cgtcacctag     5460

gggctggttt cccatgttgt catccttgct aacactggga tctcagatgt ttgcagaaca     5520

tttctattca tgacggttct tcaaagaagg gctagaatat ttgccttcta cctagagcaa     5580

agtaaaccta attgttgaag agtcaatacg tactttttgt actttcccag atttgagcca     5640

gaaaatacct acagatatct acaaatgttt tcaaccagtg ttttcgaggt agctctttaa     5700

tcctcttctc agcttttgtc tgttctgact tttcatccaa taagctgtaa gtgaactaca     5760

atctgcattt ccagcatgca attctcttcc tgctcacgga gggggatgca aaagttttct     5820

ctcacaccta atgggccctc tcttagcttt taactgttgt tttcccctgt tgatgaaaaa     5880

ttactgacat cacaaagatt gccatccatg gtagaaagga cttgatttaa agtcagaaaa     5940

atttgccttt tctttaggaa ggggaattca tgacatccat gtcctattat cggccgtaac     6000

ttcctaaaga agaaaaaggg tgaatgaaag cttatgttac ttttatgaaa gtatcactga     6060

tctcctttgg aaaagaaact ctgcttcact gtttttctac ctttatttct ctgccatcct     6120

cgtttttcct ctctgaagtt ctaaataccc tttaactgaa ccttgttggt cttgctctaa     6180

aatttagcct ctttctagag cccaagacca aaagggagtg cttcatgctg aggggctcaa     6240

gtgagctgac tctacaactg tggttctcaa ctaggggcag atttaccccc aagggtacat     6300

ttggcaatgt ctggggacat ttggttgtca tagctggggg ggaggtgatg gtatgctact     6360

ggcatcaagt ggttagaggc cacagatgct actaaacacc ctgccatgca caggacagcc     6420

ccccaaacaa acagtggtcc agccccaagc actactagtg ctgaggttga gaaaccctgc     6480

cctacaccat cccaagccca ccagtctgca gagcttggct ctggccttgt tctgtccagg     6540

ctacagtact gcaggtgtga tttcttcaac atcacattct cttaagagtc ttcaaccact     6600

atgcctgaat ccttggaatc ctattgttcg tttccattgt cttgggcctg ctaaaaggtg     6660

catactttgg aaggagacca gagttacttt ataggtgttg gagaacttaa attctaggtt     6720

agcatcctta gaaaatcttt catagagcca tgaggcttat atttagaagc aagcaacagc     6780

ctggcagatt ggcatgattt ttaccaactg ctcaaaggca tccgtggctt tcagctgtgt     6840

ctcccgaaag aaaatgtctt tgttttttat tcaagtcatt taatagctct ttacaaatat     6900

tagcatatgg cagaccaatt agaagcaaaa aagtccgtat tggtggttgt gatgtggctg     6960

ttatagaagt atttgtgctg tatgctttgg ttaaatctgt tttaaaacat gctttaagat     7020

tcaccttacg cagttgtact ttaattctaa gctcagagct atgctgtcag tctctagtca     7080

cgccatgtat tataaagtat gttgtggttg tagagttagc cagtttagca tgttcctaat     7140

ctgagaatta gtggactata ctaggaaatg ctatcccatt ttccctttcc agcccctctt     7200

agttaagatc atagtatcct cacttcttaa actagtcttt agagtaaata aggaaaaaag     7260

ccatttattt tcttctagcc atgtattatt gagaatgact catagtacaa ctttttttca     7320

aaggccagag gattactttg caagtgtgta gaaagatctg tctatttctg ttcacctggg     7380

acctggtggt gactgaactc tttcagcaag ggcaatggct caatgtgatt cggtgctgga     7440

gctcagctgg gactcagtaa atctgcacgt tctctgctgg tcagaacatg tttcctggag     7500

agcattgctt ttctatctag aagttcgtta cctcctgcat gatagtggga tattgagatg     7560

tgggttctaa gatccacaga ctcatacttt tgtgaacttt ggaatgtggt agggtacact     7620

gaaccaagtc agaaaatagt gaaatatttc cttgcctcct tcagttcatc actaagaaag     7680

tgtgtaggca gagaaaactt acttatggtt tgaagaacca caattgtttt tgaaagggga     7740

catagaaaag acagtacaaa ggttgtaagt gtcctgtcgc taattcccag ggccagaatc     7800

tcacaagaag atcctctcaa agacttaaaa gcctggctta caaaaataac cagaaaccaa     7860

acttgtaagc agttacaatt tcttcctttt gcttcttgac cagctgagat acagaatatc     7920

ttgaggtctg gttcagctga tgaaaaattc tgtctcagaa acgatgagta agaaaccata     7980

caagaaaaag aagtccctca tctatctgca tacacgcaat gtgggagaag tggggtggct     8040

aggaaactct gggcctgctg cccccttcga ttcttttttt ttttctttgt gaattgaatg     8100

tacgatacaa atggtaggcc ttcatgtgag ccagttacta catgaatctt catttcccac     8160

agtggtttgt tcattcatca gcgttaggct tggtcctggc tccacctttc tcctctccgg     8220

gcactgaccc cacctttccg tgtatttact gtaggctatt aaatatgatc atgacccgcc     8280

ttgcattttc attcatcacc tgtttatgcc caaatttaaa ggaagtttgt ctcattttgc     8340

cagaaaaaaa ttgtaatagt cggcacgctg gatttgtagg gccagcaaaa ttgcggcagt     8400

gaaactagtt tcacttctaa agcccttcat ttcccacaag gttaagctct cgaaacccca     8460

tttgatcctt ggttcctatt tcgatcctcc tttggaatct gaaaatcggt ctccatgttg     8520

tatgcagatt agaagttgcc ttgtttgtta ctcttccaac acagggtatc agggagaaag     8580

aggccttatc tgttcctcca tcccccctgt tttgacagac tgctaagaat tcctcaggac     8640

ttcctttggt tggggatttt actttcccaa aagtctgatc tgatttcttt caggggtaga     8700

caagcttgtc ctagtgctct gcttcaggtc ttatcagaag aaacccagga atagaaaagg     8760

tagatgcctt gacttttgtc cctgttgtgg ggactaaagt gttttttgcc agaattgtca     8820

aaagctccgg ttcaaactct gtagagtttc atggaaaaac aaaacaaaac aaaaaagatg     8880

cttatcgtcc cggagaatgt gtaagtaagt tctccagcac ggcttaggtt ttccaaaatg     8940

gaaagcaaag cttgcagaca acctgttttc tctagagaca cacaatgatt ctggccctca     9000

gtctgtttcc ctccccttgt ttactctttg gtcaccgatc gagtcaggct agaggggtaa     9060

tacggtgatt aaaagaagta aattctcact gtaaacttgg attgattaac agaaacaatt     9120

aaaccaaaca aaatcattgc cccaaatttc tatctccaag aattgctttg tgccattttg     9180

aattcaggta gttattctgt atatacttag ctaactattc agagcttctt caatctctag     9240

taagcttgaa ggtggtgtct gggaagacac agggcagggt gacatttaga ctctgttcat     9300

tcttaaaaat agggataagc cagaatgatg tgacatctag tatgtggtag atgaagaatc     9360

agtggaaatt cttaattgca cagactttat aatccattat ataaagtgta attccatact     9420

ttttactgtg gcaagggtgt gatgtgattg ttaatctttt taatttttga atccaaactg     9480

aatttaaagt gttgaatact taaatcctca caagtgaatt atgaaccatt tgtaaagtgt     9540

ttctataact ctttgtatca tgtgttggta catcttatca agttttttct ggcatgtaat     9600

tccattctaa acttatgtaa aatttctatt gttgctgtaa atattacaca aatatctatt     9660

ccgtgataac cttcattatc agcatgaaat ggttaatttt tactgagcac aatgtatttt     9720

tgaatggatc ttcccaaatg tctttaataa aatgcagatt ttgcactgac tgatgtgact     9780

gccaggccgt cccaatcttg agcactgtgg tccttcgtgt ttgaactgcg aacagctcca     9840

ttttagttcc ttcttgggaa gaaagaatgc attcgaattc aaatgaggga tgatgggcct     9900

ttgaggttgt aatcagtttg agacagaaat taatgtaaaa ctaggcaaat cctgtaactt     9960

aatgatgttg atctttgttt tcctatttat aaagcttttt tccccttacg gcattttgaa    10020

aactttggtt tgttttatac ttgagtgttg tcacctttgc acgtcgctag acactcacgt    10080

ggtagtttga ggaggatggg aagagaggcc aatcttgtgc taagtgctat ggagaaagca    10140

aagatgcaca gcttaataag ggttttttga ttctagagga gaggtgggca agcttttcct    10200

gtaaagggcc agatggtaaa tattgggggc tctgtggccc atcagttccc tgtcaacatt    10260

actcagctct gcctttgtat tgcagaggct gcatggataa tatgtaaatc agtaagtgtg    10320

gctgtggtcc cgtaaaactt tacttataga aacaggccat agtttactaa cccgttttag    10380

gccctcagtt tcatcattta gggtaacacc aaccgagtac atgttcaatc aggagggaaa    10440

gaacttagct tttgtgataa cttatagatg aaatattccc cagttttctt tctctttcta    10500

aacaaagggt aggagctgaa agtcagtgct ctccattctt aaaagtcctc tgtcaaccac    10560

ctcttcactc tatctcctta agtgacatgg aaacttgtgg cctgtgcttt caactataat    10620

cttaccaaga ctgaatgaaa gtatttggtg cttatacttt ttaatgttca tagcacttac    10680

tatggccagg cacaatgccc aagtgttttg ctttattatt attattatta ttattattat    10740

tattattatt attattattt tcacaacaac ccagcgaaac aggtactatt attatcccct    10800

ttttgtaaat gaggaaacag atttccatac ttgacattaa cctgcccaag gtcacccagt    10860

ttggaagtgg cagggccagg atttgaagcc gaatatgttc attgtaaagc ccatataccc    10920

ttaaaagtca ctgcacgtcc acgtatggta atgtggtcac aatcagtatt gtttctcttt    10980

agtaattcag atttattcaa gtaactccaa ggttcaaatt ttcaaaaaca gtttccaaca    11040

caggttatat taaaaacttt gcctgaagtt tactctaggt gcagaaataa agacaactta    11100

gtcaagtgaa ggaaagggta acagacttag aaatggctat ctacactgat ggaataagta    11160

tactaattag agcaggtaac aagtccccac gatgtataac atattcttct ctaaaagctc    11220

acaacaattt atgtgccacc ttccatcccc tttcccagca gatggtaatt gatgcaattt    11280

gagaatagaa cacttcattg aaacaagtca ctggaggtcc tctggggatg cagcttaaaa    11340

gcccaggatc aggccaggtg tggtggctca cgcctgtaat cccagcactg tgggagactg    11400

agacgggcag atcacctgaa gtcaggagtt cgagaccagc ctggccaata tagagaaacc    11460

ccgtctgtac taaaaataca aaaattaggt ctgggcggtg gctcacgccc gtaatcctag    11520

cactttggga ggccaaggtg ggtggatcac gaggtcagga gttcgagacc agcctggcca    11580

acatggtgaa accccgtctc tactaaaaat acaaaaattg ggtgtggtgg tacatgcctg    11640

taatcccagc tgcttaggag gctgaggcag gagaatcact tgaacccaaa aggcagaggt    11700

tgcagtgagc cgagatcacg ccactgcact ccagcctggc aacagagcga gactctgtct    11760

caaaaaaaaa aaaaaaaaaa tacaaaaatt agccgggaat ggtggtgaat gtctataatc    11820

ccagccactc gggaggctga ggcaggagaa tcacttgaac ccaaaaggca gaggttgcag    11880

tgagccaaga tcgcaccact gcactcccac ctggacgaca gagcgagacg ccatctcaaa    11940

aataaataaa taaataaatc cctaggatat agagtccgct tgcctgggtg gagtcttggc    12000

tccatctcct acatctcatg tgacttgaag caaggcactt cactatgcct cagtttcctt    12060

atctttaaat ggaggtaatc acagtaccta cctcagtgtt gttgtgaaga tttaatgaga    12120

taataacctg cagagcactt gagagtctca agaaatatga gctcttataa cattattgct    12180

attgtaaaac attgctatta cttctgtccc aatttggcag tttcaggaaa ttgagaagga    12240

atgtcactga atctttaatg ccagttacac agagctcagt aggtgtccgc acagcccttt    12300

agatgcacgt agcctatttg atcttcgtat cagccctgta aggttgggct taagaatgac    12360

ccagcatgga agtactcttg ggaccacagg ggaagcaaca gtccttgtaa gctgtttgtc    12420

agtgggcctt agcaaccaag ccccaagtgg acagaaagat ggggttctgt gagcatccat    12480

tccaagggtc actttagggg tgcaatcttc tgggctctga gaatggattc acagcagcat    12540

ctctatctgg aaataccttt gctttgtcca agtaacctcc tcccacacag agtacccgaa    12600

tcagctcaga ttttttttcc ttaatattgg caacacttaa tgctacttct ttgttcgtaa    12660

catttcattt aattatttaa aaatctgcaa atgttgtgta tattttaccg caatttttaa    12720

acaaactcca gtgtagaccg tgctctagca tttctaaaaa taaaagtaaa tatgttaaaa    12780

taaggtaaga gtgagttttt cctacactat gtataatttt taattgaaag tttcccccac    12840

aaaagaaatg atacttggaa gcatagtttg tgtgtttgac agcaagattc tattaggctt    12900

cagatttccc tcaataaaag ttttagtttt tatacattct gtcatgaatt gaatgaagta    12960

aataatatgc tgttgtaagc aaattatctg cagataaatg tcttatgaat cgtatatctt    13020

actgtttatt aaattctgaa gtattgagca gtttccaatg tgaaatccca gctggcttct    13080

ttgcaatgat ggacaagtta gttataattc atatggaaat tcaaggaacc cagaatagcc    13140

aaaacaatcc cgaagagcaa agttggagga ctcacatgcc ccaatttcaa aacttactac    13200

aaagctacaa taatgaagaa agtgaggtaa tagaatttgg agtccagaaa taaaccctct    13260

cacatttatg gtcaattgtt ttttgacaag ggtgccaaga tcattcaatg ggggaaagaa    13320

tagtcttttc agcaaatagt ggtgggacaa ctggatatcc acatgcaaaa gaatgacgtt    13380

ggactcctat ttcacaccat atacaaaaat taactcaaaa tggaacaaag atctaactgt    13440

aagaggtaga actataaaac tcatagaaga aaacataggg gtaaatcttc atgaccttgg    13500

atttggcagt ggtttctcag atatgacacc aaaggcacaa gcaaagagaa aaataaattg    13560

gacttcatca aatatttaaa attttgtgct taagaggact ctatcgagag ggttaaaaag    13620

atccacagaa tgggagaaaa tatttgcaaa tcatatccaa taagggaatt agaatataca    13680

aagaattctt aaactcagta agttgtaagc cgatttaaaa tgggcagagg atctgaaaaa    13740

cctttatcca aagatgtaca aatggccagt aaacacatga aaagatgctc aacatcatta    13800

gtcactaggg aaatgcaaat caaaaccaca gttgagatgc aacttcacac attatgggta    13860

tagtcaaaga tggacagtaa caagtgttgc tgaggatgtg gagaaagtgg aagcctccta    13920

cattgctggt ggaaatgtaa aatgatgcag ccacttggga taatagttcc tccaaagatt    13980

aaacaagagt gactgtgtgt cccagcagtt ttactcctaa gtatataccc aagataaatg    14040

aaaacacaca tccgcacaaa aacttataca caaatgttca tagcagcatt attcataata    14100

gctaaagagt ggaaacccaa atatccatca atggatgaat ggataaataa caatgtgctc    14160

ttgacatgat actgaacaat gatgttcagc aataaaaagg agtgacaagt gacatagtga    14220

tacacatgtt ataacgtgga tgaactttaa aacactatgc taagtgaaag aagccagtca    14280

cgaaatacca catactatat gatttcattt atgtagaacg tccagaaggc caatctacag    14340

agacagtcga ttcgtggttg cagagggctt ggggtggccg atgggttggg gagtgttggc    14400

tgatgggtgc aggatttctc tttggggtga taaactttct aaaattgatc tagtgataat    14460

ggttgcacaa ctctgaatat accaaaagtc atcaaattgt acactttaaa tggatacaaa    14520

ttgtatgtga acttaatctc aataaagccg tgacaaaagt ttccaacatg aa            14572


<210>  18
<211>  3434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  transcript variant

<400>  18
attagttgtc tctgccgctg gggaaggtaa agcggcgacg gcgtcctcag gagctgtggg       60

gtcccctgct agaagtgggg gactcggcgg gggagtcatt taatacttca tgattagaac      120

aaatatgtga aagttcccac caaccagtga gaatttcttc cttcagacgg ttttggatct      180

tactgcacag ctttctgaga agttcttttg gtgccatgtt ttgtggcttg catcaaaaga      240

ggagtttgtc ttcatgaaga ttcctaacat tggtaatgtg atgaataaat ttgagatcct      300

tggggttgta ggtgaaggag cctatggagt tgtacttaaa tgcagacaca aggaaacaca      360

tgaaattgtg gcgatcaaga aattcaagga cagtgaagaa aatgaagaag tcaaagaaac      420

gactttacga gagcttaaaa tgcttcggac tctcaagcag gaaaacattg tggagttgaa      480

ggaagcattt cgtcggaggg gaaagttgta cttggtgttt gagtatgttg aaaaaaatat      540

gctcgaattg ctggaagaaa tgccaaatgg agttccacct gagaaagtaa aaagctacat      600

ctatcagcta atcaaggcta ttcactggtg ccataagaat gatattgtcc atcgagatat      660

aaaaccagaa aatctcttaa tcagccacaa tgatgtccta aaactgtgtg actttggttt      720

tgctcgtaat ctgtcagaag gcaataatgc taattacaca gagtacgttg ccaccagatg      780

gtatcggtcc ccagaactct tacttggcgc tccctatgga aagtccgtgg acatgtggtc      840

ggtgggctgt attcttgggg agcttagcga tggacagcct ttatttcctg gagaaagtga      900

aattgaccaa ctttttacta ttcagaaggt gctaggacca cttccatctg agcagatgaa      960

gcttttctac agtaatcctc gcttccatgg gctccggttt ccagctgtta accatcctca     1020

gtccttggaa agaagatacc ttggaatttt gaatagtgtt ctacttgacc taatgaagaa     1080

tttactgaag ttggacccag ctgacagata cttgacagaa cagtgtttga atcaccctac     1140

atttcaaacc cagagacttc tggatcgttc tccttcaagg tcagcaaaaa gaaaacctta     1200

ccatgtggaa agcagcacat tgtctaatag aaaccaagcc ggcaaaagta ctgctttgca     1260

gtctcaccac agatctaaca gcaaggacat ccagaacctg agtgtaggcc tgccccgggc     1320

tgacgaaggt ctccctgcca atgaaagctt cctaaatgga aaccttgctg gagctagtct     1380

tagtccactg cacaccaaaa cctaccaagc aagcagccag cctgggtcta ccagcaaaga     1440

tctcaccaac aacaacatac cacaccttct tagcccaaaa gaagccaagt caaaaacaga     1500

gtttgatttt aatattgacc caaagccttc agaaggccca gggacaaagt acctcaagtc     1560

aaacagcaga tctcagcaga accgccactc attcatggaa agctctcaaa gcaaagctgg     1620

gacactgcag cccaatgaaa agcagagtcg gcatagctat attgacacaa ttccccagtc     1680

ctctaggagt ccctcctaca ggaccaaggc caaaagccat ggggcactga gtgactccaa     1740

gtctgtgagc aacctttctg aagccagggc ccaaattgcg gagcccagta ccagtaggta     1800

cttcccatct agctgcttag acttgaattc tcccaccagc ccaaccccca ccagacacag     1860

tgacacgaga actttgctca gcccttctgg aagaaataac cgaaatgagg gaacgctgga     1920

ctcacgtcga accacaacca gacattctaa gacgatggag gaattgaagc tgccggagca     1980

catggacagt agccattccc attcactgtc tgcacctcac gaatcttttt cttatggact     2040

gggctacacc agcccctttt cttcccagca acgtcctcat aggcattcta tgtatgtgac     2100

ccgtgacaaa gtgagagcca agggcttgga tggaagcttg agcatagggc aagggatggc     2160

agctagagcc aacagcctgc aactcttgtc accccagcct ggagaacagc tccctccaga     2220

gatgactgtg gcaagatctt cggtcaaaga gacctccaga gaaggcacct cttccttcca     2280

tacacgccag aagtctgagg gtggagtgta tcatgaccca cactctgatg atggcacagc     2340

ccccaaagaa aatagacacc tatacaatga tcctgtgcca aggagagttg gtagctttta     2400

cagagtgcca tctccacgtc cagacaattc tttccatgaa aataatgtgt caactagagt     2460

ttcttctcta ccatcagaga gcagttctgg aaccaaccac tcaaaaagac aaccagcatt     2520

cgatccatgg aaaagtcctg aaaatattag tcattcagag caactcaagg aaaaagagaa     2580

gcaaggattt ttcaggtcaa tgaaaaagaa aaagaagaaa tctcaaacag tacccaattc     2640

cgacagccct gatcttctga cgttgcagaa atccattcat tctgctagca ctccaagcag     2700

cagaccaaag gagtggcgcc ccgagaagat ctcagatctg cagacccaaa gccagccatt     2760

aaaatcactg cgcaagttgt tacatctctc ttcggcctca aatcacccgg cttcctcaga     2820

tccccgcttc cagcccttaa cagctcaaca aaccaaaaat tccttctcag aaattcggat     2880

tcaccccctg agccaggcct ctggcgggag cagcaacatc cggcaggaac ccgcaccgaa     2940

gggcaggcca gccctccagc tgccagacgg tggatgtgat ggcagaagac agagacacca     3000

ttctggaccc caagatagac gcttcatgtt aaggacgaca gaacaacaag gagaatactt     3060

ctgctgtggt gacccaaaga agcctcacac tccgtgcgtc ccaaaccgag cccttcatcg     3120

tccaatctcc agtcctgctc cctatccagt actccaggtc cgaggcactt ccatgtgccc     3180

gacactccag gtccgaggca ctgatgcttt cagctgccca acccagcaat ccgggttctc     3240

tttcttcgtg agacacgtta tgagggaagc cctgattcac agggcccagg taaaccaagc     3300

tgcgctcctg acataccatg agaatgcggc actgacgggc aagtgacttc tgcaagcctg     3360

cggctggtcc caatgccctg aatcacctct ctcatggaag aaccaattaa caccaatgaa     3420

tcaaccatta aaaa                                                       3434


<210>  19
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  19

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
            900                 905                 910         


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
        915                 920                 925             


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
    930                 935                 940                 


His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser 
945                 950                 955                 960 


Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro 
                965                 970                 975     


Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln 
            980                 985                 990         


Ser Gly Phe Ser Phe Phe Val Arg  His Val Met Arg Glu  Ala Leu Ile 
        995                 1000                 1005             


His Arg  Ala Gln Val Asn Gln  Ala Ala Leu Leu Thr  Tyr His Glu 
    1010                 1015                 1020             


Asn Ala  Ala Leu Thr Gly Lys  
    1025                 1030 


<210>  20
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  20

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210>  21
<211>  1030
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  amino acid sequence

<400>  21

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Asp Gly Gly Cys Asp Gly Arg Arg 
            900                 905                 910         


Gln Arg His His Ser Gly Pro Gln Asp Arg Arg Phe Met Leu Arg Thr 
        915                 920                 925             


Thr Glu Gln Gln Gly Glu Tyr Phe Cys Cys Gly Asp Pro Lys Lys Pro 
    930                 935                 940                 


His Thr Pro Cys Val Pro Asn Arg Ala Leu His Arg Pro Ile Ser Ser 
945                 950                 955                 960 


Pro Ala Pro Tyr Pro Val Leu Gln Val Arg Gly Thr Ser Met Cys Pro 
                965                 970                 975     


Thr Leu Gln Val Arg Gly Thr Asp Ala Phe Ser Cys Pro Thr Gln Gln 
            980                 985                 990         


Ser Gly Phe Ser Phe Phe Val Arg  His Val Met Arg Glu  Ala Leu Ile 
        995                 1000                 1005             


His Arg  Ala Gln Val Asn Gln  Ala Ala Leu Leu Thr  Tyr His Glu 
    1010                 1015                 1020             


Asn Ala  Ala Leu Thr Gly Lys  
    1025                 1030 


<210>  22
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  22
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgttgtcgga       60

gaaggcgctt atggcgtggt gctgaagtgc agacacaaag aaacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaagagaac gaggaagtga aagagacaac cctgcgcgag      180

ctgaagatgc tgagaaccct gaagcaagag aacatcgtgg aactgaaaga ggccttccgg      240

cggagaggca agctgtacct ggtgttcgag tacgtggaaa agaacatgct cgagctgctg      300

gaagagatgc ccaatggcgt gccacctgag aaagtgaagt cctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gagacatcaa gcccgagaac      420

ctgctgatct cccacaacga cgtgctgaag ctgtgcgact tcggcttcgc cagaaatctg      480

agcgagggca acaacgccaa ctacaccgag tatgtggcca ccagatggta cagaagccct      540

gaactgctgc tgggagcccc ttacggcaag tctgtggata tgtggtccgt gggctgtatc      600

ctgggagagc tgtctgatgg ccaacctctg tttcctggcg agtccgagat cgaccagctg      660

ttcacaatcc agaaggtgct gggccctctg cctagcgagc agatgaagct gttctacagc      720

aaccccagat tccacggcct gagattccct gccgtgaatc accctcagag cctggaaaga      780

agatacctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaatct gctgaaactg      840

gaccccgccg acagatacct gaccgagcag tgtctgaacc atcctacctt tcagacccag      900

agactgctgg atagaagccc cagcagaagc gccaagagaa agccctacca cgtggaaagc      960

agcaccctga gcaatagaaa ccaggccgga aagagcactg ccctgcagag ccaccacaga     1020

agcaacagca aggacatcca gaacctgagc gtgggcctgc ctagagctga tgaaggactg     1080

cctgccaacg agagcttcct gaatggaaat ctggctggcg cctctctgag ccctctgcac     1140

acaaagacat accaggccag cagccagcct ggcagcacaa gcaaggacct gaccaacaac     1200

aacatccctc atctgctgag ccccaaagag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcctagcga aggccctggc accaagtacc tgaagtccaa ctccagaagc     1320

cagcagaacc ggcactcctt catggaaagc tctcagagca aggccggcac actgcagcct     1380

aacgagaagc agagcagaca cagctacatc gacacaatcc ctcagtcctc tcggagcccc     1440

agctacagaa caaaggccaa atctcacggc gccctgagcg atagcaagag cgtgtccaat     1500

ctgtccgagg ctagagccca gatcgccgag cctagcacca gcagatactt ccctagcagc     1560

tgcctggatc tgaacagccc tacaagcccc acacctacca ggcacagcga taccagaaca     1620

ctgctgtccc caagcggccg gaacaacaga aatgagggca ccctggacag cagacggacc     1680

accacaagac acagcaagac catggaagaa ctgaagctgc ccgagcacat ggactctagc     1740

cactctcatt ctctgagcgc ccctcacgag tcctttagct acggcctggg ctacacaagc     1800

ccattttcca gtcagcagcg gccccacaga cactctatgt acgtgaccag agacaaagtc     1860

cgcgccaaag gcctggatgg ctctctgtct attggacaag gcatggccgc cagagccaat     1920

agcctgcaac ttctgtctcc tcagcctggc gaacagctgc ctcctgaaat gacagtggcc     1980

cggtccagcg tgaaagaaac cagcagagag ggcacctcca gcttccacac cagacagaaa     2040

agcgaaggcg gcgtgtacca cgatcctcac tctgatgatg gcacagcccc taaagagaac     2100

agacacctgt acaacgaccc cgtgcctaga agagtgggct ccttctacag agtgccttct     2160

cctagacctg acaactcctt ccacgagaac aacgtgtcaa cccgggtgtc cagcctgcct     2220

tctgagagca gctctggcac aaaccactcc aagaggcagc ccgccttcga tccttggaag     2280

tcccctgaga atatcagcca ctccgagcag ctgaaagaga aagagaagca gggctttttc     2340

cggtccatga agaagaagaa aaagaagtcc cagacagtcc ccaacagcga cagccctgat     2400

ctcctgacac tgcagaagtc catccacagc gccagcacac ctagcagcag acctaaagag     2460

tggcggccag agaagatcag cgacctgcaa acacagagcc agcctctgaa gtccctgagg     2520

aagctgctgc atctgtcctc cgcctctaat caccctgcca gcagcgatcc cagatttcag     2580

ccactgacag cccagcagac caagaactcc ttcagcgaga tccggattca cccactgtct     2640

caggccagcg gcggcagctc taatatcaga caagagcccg ctcctaaggg cagacctgct     2700

ctccaactgc ctggacagat ggatcctggc tggcacgtgt cctctgtgac aagatctgcc     2760

accgagggac ctagctattc tgagcagctg ggcgccaagt ctggccccaa tggacacccc     2820

tacaaccgga ccaatcggag cagaatgccc aacctgaacg acctcaaaga aacagccctc     2880

tga                                                                   2883


<210>  23
<211>  466
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  promoter

<400>  23
ctgcagaggg ccctgcgtat gagtgcaagt gggttttagg accaggatga ggcggggtgg       60

gggtgcctac ctgacgaccg accccgaccc actggacaag cacccaaccc ccattcccca      120

aattgcgcat cccctatcag agagggggag gggaaacagg atgcggcgag gcgcgtgcgc      180

actgccagct tcagcaccgc ggacagtgcc ttcgcccccg cctggcggcg cgcgccaccg      240

ccgcctcagc actgaaggcg cgctgacgtc actcgccggt cccccgcaaa ctccccttcc      300

cggccacctt ggtcgcgtcc gcgccgccgc cggcccagcc ggaccgcacc acgcgaggcg      360

cgagataggg gggcacgggc gcgaccatct gcgctgcggc gccggcgact cagcgctgcc      420

tcagtctgcg gtgggcagcg gaggagtcgt gtcgtgcctg agagcg                     466


<210>  24
<211>  3009
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  24
atgaagatcc ccaatatcgg caacgtgatg aataagttcg agatcctggg agtggtggga       60

gagggagcat acggcgtggt gctgaagtgc agacacaagg agacacacga gatcgtggcc      120

atcaagaagt ttaaggatag cgaggagaat gaggaggtga aggagacaac cctgcgcgag      180

ctgaagatgc tgcggacact gaagcaggag aacatcgtgg agctgaagga ggccttccgg      240

agaaggggca agctgtacct ggtgtttgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ctaatggcgt gccccctgag aaggtgaaga gctacatcta tcagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcacc gcgatatcaa gccagagaac      420

ctgctgatca gccacaatga cgtgctgaag ctgtgcgatt tcggctttgc ccggaacctg      480

tccgagggca acaacgccaa ttacacagag tacgtggcaa ccaggtggta ccggtcccct      540

gagctgctgc tgggagcacc atacggcaag tctgtggaca tgtggagcgt gggctgcatc      600

ctgggagagc tgtccgacgg acagccactg ttccctggcg agtctgagat cgatcagctg      660

tttaccatcc agaaggtgct gggccccctg ccttccgagc agatgaagct gttctactct      720

aacccaaggt tccacggcct gaggtttcca gccgtgaatc acccccagtc tctggagcgc      780

cggtatctgg gcatcctgaa cagcgtgctg ctggatctga tgaagaatct gctgaagctg      840

gaccctgccg atcgctacct gaccgagcag tgtctgaatc acccaacatt tcagacccag      900

agactgctgg acaggagccc ctcccgctct gccaagagga agccttatca cgtggagagc      960

tccaccctga gcaatcgcaa ccaggccggc aagtccacag ccctgcagtc tcaccaccgg     1020

agcaactcca aggacatcca gaatctgagc gtgggcctgc caagggcaga cgagggcctg     1080

cctgccaacg agtccttcct gaatggaaac ctggcaggag cctctctgag cccactgcac     1140

acaaagacct accaggcctc tagccagcct ggctccacat ctaaggacct gaccaacaat     1200

aacatccctc acctgctgag cccaaaggag gccaagtcca agaccgagtt cgactttaat     1260

atcgatccaa agcccagcga gggcccaggc acaaagtatc tgaagagcaa ctccagatct     1320

cagcagaata ggcactcttt catggagtcc tctcagagca aggccggcac cctgcagccc     1380

aacgagaagc agagcaggca ctcctacatc gataccatcc cacagagctc ccgcagcccc     1440

tcctatcgga caaaggccaa gagccacggc gccctgtctg acagcaagtc cgtgtctaat     1500

ctgtccgagg caagagcaca gatcgcagag ccaagcacct ccaggtactt tccctcttcc     1560

tgtctggacc tgaactctcc aacaagccct acaccaacca gacacagcga tacaaggacc     1620

ctgctgtctc ccagcggcag aaataacagg aacgagggca ccctggatag cagaaggacc     1680

acaaccagac actccaagac aatggaggag ctgaagctgc ccgagcacat ggactcctct     1740

cactcccact ctctgagcgc ccctcacgag tccttctctt acggcctggg ctataccagc     1800

ccttttagct cccagcagcg cccacacagg cactccatgt acgtgacaag agacaaggtg     1860

agggccaagg gcctggacgg cagcctgtcc atcggacagg gaatggcagc aagggcaaat     1920

agcctgcagc tgctgtcccc acagcctgga gagcagctgc caccagagat gaccgtggcc     1980

agatctagcg tgaaggagac aagcagggag ggcacctcct ctttccacac aagacagaag     2040

agcgagggcg gcgtgtatca cgacccacac tccgacgacg gaaccgcacc caaggagaac     2100

aggcacctgt acaacgatcc agtgccccgc cgggtgggct ctttctatcg ggtgcctagc     2160

ccacggcccg acaactcctt tcacgagaat aacgtgtcta ccagagtgag ctccctgcct     2220

agcgagtcta gctccggcac aaaccactcc aagaggcagc cagcctttga tccctggaag     2280

tctcctgaga atatctctca cagcgagcag ctgaaggaga aggagaagca gggcttcttt     2340

cgcagcatga agaagaagaa gaagaagagc cagacaaccg acagcaccaa cggcgagaat     2400

cctagcatca agaagtccct gttcccactg tttaactcca agaatcacct gaagcactct     2460

agctccctga agaagctgcc cgtggtgaca cctccaatgg tgcccaattc cgactctcct     2520

gatctgctga ccctgcagaa gagcatccac agcgcctcca caccatctag cagacccaag     2580

gagtggaggc cagagaagat ctccgatctg cagacccagt cccagcccct gaagtctctg     2640

cggaagctgc tgcacctgtc ctctgccagc aaccaccctg caagctccga ccctaggttc     2700

cagccactga cagcccagca gaccaagaac tcttttagcg agatcagaat ccacccactg     2760

tcccaggcct ctggaggctc tagcaacatc cgccaggagc ctgccccaaa gggccggcca     2820

gccctgcagc tgccaggaca gatggacccc ggctggcacg tgtcctctgt gacaagatcc     2880

gccaccgagg gaccatccta ctctgagcag ctgggagcaa agtctggacc aaacggacac     2940

ccttataaca ggaccaatag atccaggatg cctaatctga acgacctgaa ggagacagcc     3000

ctgtgatag                                                             3009


<210>  25
<211>  2835
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  25
atgaagatcc ccaatatcgg caacgtgatg aataagttcg agatcctggg agtggtggga       60

gagggagcat acggagtggt gctgaagtgc cggcacaagg agacacacga gatcgtggcc      120

atcaagaagt ttaaggatag cgaggagaat gaggaggtga aggagacaac cctgagggag      180

ctgaagatgc tgcgcacact gaagcaggag aacatcgtgg agctgaagga ggccttccgg      240

agaaggggca agctgtacct ggtgtttgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ctaatggcgt gccccctgag aaggtgaaga gctacatcta tcagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gggatatcaa gccagagaac      420

ctgctgatca gccacaatga cgtgctgaag ctgtgcgatt tcggctttgc ccgcaacctg      480

tccgagggca acaacgccaa ttacacagag tacgtggcaa ccaggtggta ccggtcccca      540

gagctgctgc tgggagcacc atacggcaag agcgtggaca tgtggtccgt gggctgcatc      600

ctgggcgagc tgtctgacgg ccagcctctg ttcccaggcg agagcgagat cgatcagctg      660

tttaccatcc agaaggtgct gggccctctg ccaagcgagc agatgaagct gttctactcc      720

aaccctaggt tccacggcct gcgctttccc gccgtgaatc accctcagag cctggagcgc      780

cggtatctgg gcatcctgaa ctccgtgctg ctggatctga tgaagaatct gctgaagctg      840

gaccccgccg ataggtacct gaccgagcag tgtctgaacc accccacatt ccagacccag      900

agactgctgg acaggtcccc ttctcgcaat caggccggca agtctacagc cctgcagagc      960

caccacagga gcaactccaa ggacatccag aatctgagcg tgggcctgcc tagggcagac     1020

gagggcctgc cagcaaacga gtcctttctg aatggaaacc tggcaggagc ctctctgagc     1080

ccactgcaca caaagaccta ccaggccagc tcccagccag gctccacatc taaggatctg     1140

accaacaata acatcccaca cctgctgtct cccaaggagg ccaagagcaa gaccgagttc     1200

gactttaata tcgatcccaa gcctagcgag ggcccaggca caaagtatct gaagagcaac     1260

tcccggagcc agcagaatag acactccttc atggagtcta gccagtctaa ggccggcacc     1320

ctgcagccca acgagaagca gagccgccac tcctacatcg ataccatccc ccagtcctct     1380

aggagccctt cctatcgcac aaaggccaag agccacggcg ccctgtctga cagcaagtcc     1440

gtgtctaatc tgtccgaggc aagggcacag atcgcagagc ccagcacctc cagatacttt     1500

cctagctcct gtctggacct gaactctcca acaagcccaa cacccacccg gcacagcgat     1560

acaagaaccc tgctgtctcc cagcggcaga aataacagga acgagggcac cctggattct     1620

agaaggacca caacccggca cagcaagaca atggaggagc tgaagctgcc cgagcacatg     1680

gactctagcc actcccactc tctgagcgcc cctcacgagt ccttctctta cggcctgggc     1740

tatacctccc cattttcctc tcaacagcgc ccccaccggc actctatgta cgtgacacgg     1800

gacaaggtga gagccaaggg cctggacggc agcctgtcca tcggacaggg aatggcagca     1860

agagcaaact ccctgcagct gctgtctcct cagccaggag agcagctgcc accagagatg     1920

accgtggcac ggagctccgt gaaggagaca agcagagagg gcacctctag cttccacaca     1980

cggcagaagt ccgagggcgg cgtgtatcac gaccctcact ctgacgacgg caccgcccca     2040

aaggagaaca gacacctgta caacgatcca gtgcctagga gggtgggctc cttctatcgg     2100

gtgccatctc cccgccctga caatagcttt cacgagaata acgtgtccac ccgggtgtcc     2160

tctctgccct ctgagagctc ctctggcaca aaccactcta agagacagcc cgcctttgac     2220

ccttggaaga gcccagagaa tatctctcac agcgagcagc tgaaggagaa ggagaagcag     2280

ggcttcttta ggagcatgaa gaagaagaag aagaagagcc agaccgtgcc taactccgac     2340

tctcccgatc tgctgaccct gcagaagagc atccacagcg cctccacacc aagctcccgg     2400

cctaaggagt ggcggcccga gaagatctcc gatctgcaga cccagagcca gccactgaag     2460

tccctgcgca agctgctgca cctgtctagc gccagcaacc accctgcctc ctctgaccca     2520

aggttccagc ccctgacagc ccagcagacc aagaactctt ttagcgagat ccgcatccac     2580

ccactgtccc aagcctctgg aggcagctcc aacatcaggc aggagccagc accaaagggc     2640

cgccccgccc tgcagctgcc tggacagatg gaccccggat ggcacgtgtc tagcgtgaca     2700

cggtccgcca ccgagggacc atcctactct gagcagctgg gagcaaagag cggacctaac     2760

ggacacccat ataacagaac caatagatcc aggatgccta atctgaacga cctgaaggag     2820

acagccctgt gatag                                                      2835


<210>  26
<211>  2958
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  26
atgaagatcc ccaatatcgg caacgtgatg aataagttcg agatcctggg agtggtggga       60

gagggagcat acggagtggt gctgaagtgc cggcacaagg agacacacga gatcgtggcc      120

atcaagaagt ttaaggatag cgaggagaat gaggaggtga aggagacaac cctgagggag      180

ctgaagatgc tgcgcacact gaagcaggag aacatcgtgg agctgaagga ggccttccgg      240

agaaggggca agctgtacct ggtgtttgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc caaatggcgt gccccctgag aaggtgaagt cctacatcta tcagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gggatatcaa gcccgagaac      420

ctgctgatct cccacaatga cgtgctgaag ctgtgcgatt tcggctttgc ccgcaacctg      480

agcgagggca acaacgccaa ttacacagag tacgtggcaa ccaggtggta ccggagccct      540

gagctgctgc tgggagcacc atacggcaag tctgtggaca tgtggagcgt gggctgcatc      600

ctgggagagc tgtccgacgg acagccactg ttccctggcg agtctgagat cgatcagctg      660

tttaccatcc agaaggtgct gggccccctg ccttccgagc agatgaagct gttctactct      720

aaccctaggt tccacggcct gcgctttcca gccgtgaatc acccccagtc tctggagcgc      780

cggtatctgg gcatcctgaa cagcgtgctg ctggatctga tgaagaatct gctgaagctg      840

gaccccgccg ataggtacct gaccgagcag tgtctgaacc accctacatt ccagacccag      900

agactgctgg acaggtcccc atctcgcaat caggccggca agtccacagc cctgcagtct      960

caccacagga gcaactccaa ggacatccag aatctgtccg tgggcctgcc aagggcagac     1020

gagggcctgc ctgccaacga gagctttctg aatggaaacc tggcaggagc ctctctgagc     1080

ccactgcaca caaagaccta ccaggccagc tcccagcctg gctccacatc taaggacctg     1140

accaacaata acatccctca cctgctgagc ccaaaggagg ccaagtccaa gaccgagttc     1200

gactttaata tcgatccaaa gccatccgag ggaccaggaa caaagtatct gaagagcaac     1260

tcccggagcc agcagaatag acactctttc atggagtcta gccagagcaa ggccggcacc     1320

ctgcagccta acgagaagca gagccgccac tcctacatcg ataccatccc acagtcctct     1380

aggagcccct cctatcgcac aaaggccaag tcccacggcg ccctgtctga cagcaagtcc     1440

gtgtctaatc tgagcgaggc aagggcacag atcgcagagc caagcacctc cagatacttt     1500

cccagctcct gtctggacct gaactctccc acaagcccta caccaacccg gcacagcgat     1560

acaagaaccc tgctgtctcc tagcggcaga aataacagga acgagggcac cctggatagc     1620

agaaggacca caaccaggca ctccaagaca atggaggagc tgaagctgcc tgagcacatg     1680

gactctagcc actcccactc tctgagcgcc ccacacgagt ccttctctta cggcctgggc     1740

tataccagcc ctttttcctc tcaacaacgc ccacaccggc actccatgta cgtgacacgg     1800

gacaaggtga gagccaaggg cctggacggc agcctgtcca tcggacaggg aatggcagca     1860

agggcaaata gcctgcagct gctgtcccca cagcctggag agcagctgcc accagagatg     1920

accgtggcac ggagctccgt gaaggagaca agcagagagg gcacctctag cttccacaca     1980

cggcagaaga gcgagggcgg cgtgtatcac gacccacact ccgacgacgg aaccgcacct     2040

aaggagaaca gacacctgta caacgatcca gtgccccgcc gggtgggctc tttctatcgg     2100

gtgcctagcc cacgccccga caactccttt cacgagaata acgtgtctac ccgggtgtcc     2160

tctctgccca gcgagagctc ctctggcaca aaccactcca agagacagcc agcctttgat     2220

ccctggaagt ctcctgagaa tatctctcac agcgagcagc tgaaggagaa ggagaagcag     2280

ggcttctttc ggtccatgaa gaagaagaag aagaagagcc agacaaccga cagcaccaac     2340

ggcgagaatc caagcatcaa gaagtccctg ttccccctgt ttaacagcaa gaatcacctg     2400

aagcacagct cctctctgaa gaagctgccc gtggtgacac ctccaatggt gcccaattcc     2460

gactctcctg atctgctgac cctgcagaag tccatccaca gcgcctccac accaagctcc     2520

cggcccaagg agtggcggcc cgagaagatc agcgatctgc agacccagtc ccagcccctg     2580

aagtctctga gaaagctgct gcacctgtct agcgcctcca accacccagc ctcctctgac     2640

cctcggttcc agccactgac agcccagcag accaagaact cttttagcga gatccgcatc     2700

cacccactgt cccaagcctc tggaggcagc tccaacatca ggcaggagcc tgccccaaag     2760

ggccgcccag ccctgcagct gccaggacag atggaccccg gctggcacgt gtctagcgtg     2820

acacggagcg ccaccgaggg accttcctac tctgagcagc tgggagcaaa gtctggacca     2880

aacggacacc cttataacag aaccaataga agcaggatgc caaatctgaa cgacctgaag     2940

gagacagccc tgtgatag                                                   2958


<210>  27
<211>  588
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  27
tcaacctctg gattacaaaa tttgtgaaag attgactggt attcttaact atgttgctcc       60

ttttacgcta tgtggatacg ctgctttaat gcctttgtat catgctattg cttcccgtat      120

ggctttcatt ttctcctcct tgtataaatc ctggttgctg tctctttatg aggagttgtg      180

gcccgttgtc aggcaacgtg gcgtggtgtg cactgtgttt gctgacgcaa cccccactgg      240

ttggggcatt gccaccacct gtcagctcct ttccgggact ttcgctttcc ccctccctat      300

tgccacggcg gaactcatcg ccgcctgcct tgcccgctgc tggacagggg ctcggctgtt      360

gggcactgac aattccgtgg tgttgtcggg gaaatcatcg tcctttcctt ggctgctcgc      420

ctgtgttgcc acctggattc tgcgcgggac gtccttctgc tacgtccctt cggccctcaa      480

tccagcggac cttccttccc gcggcctgct gccggctctg cggcctcttc cgcgtcttcg      540

ccttcgccct cagacgagtc ggatctccct ttgggccgcc tccccgca                   588


<210>  28
<211>  239
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  nucleic acid sequence

<400>  28
ggccgcttcg agcagacatg ataagataca ttgatgagtt tggacaaacc acaactagaa       60

tgcagtgaaa aaaatgcttt atttgtgaaa tttgtgatgc tattgcttta tttgtaacca      120

ttataagctg caataaacaa gttaacaaca acaattgcat tcattttatg tttcaggttc      180

agggggagat gtgggaggtt ttttaaagca agtaaaacct ctacaaatgt ggtaaaatc       239


<210>  29
<211>  7627
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  promoter
<222>  (226)..(1454)
<223>  UbC promoter

<220>
<221>  misc_feature
<222>  (308)..(308)
<223>  Insertion (C)

<220>
<221>  misc_feature
<222>  (1009)..(1009)
<223>  Insertion (G)

<220>
<221>  CDS
<222>  (1470)..(4352)
<223>  hCDKL5_1

<220>
<221>  misc_feature
<222>  (4353)..(4353)
<223>  Deletion (G)

<220>
<221>  misc_feature
<222>  (4370)..(4391)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4396)..(4417)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4424)..(4445)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4452)..(4473)
<223>  miRNA183

<220>
<221>  polyA_signal
<222>  (4482)..(4608)
<223>  Rabbit Globin polyA

<220>
<221>  misc_feature
<222>  (4639)..(4677)
<223>  AAV2 seq upstream of 3'ITR

<220>
<221>  repeat_region
<222>  (4677)..(4806)
<223>  3'ITR

<400>  29
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcat gctctaggaa gatctggcct ccgcgccggg      240

ttttggcgcc tcccgcgggc gcccccctcc tcacggcgag cgctgccacg tcagacgaag      300

ggcgcagcga gcgtcctgat ccttccgccc ggacgctcag gacagcggcc cgctgctcat      360

aagactcggc cttagaaccc cagtatcagc agaaggacat tttaggacgg gacttgggtg      420

actctagggc actggttttc tttccagaga gcggaacagg cgaggaaaag tagtcccttc      480

tcggcgattc tgcggaggga tctccgtggg gcggtgaacg ccgatgatta tataaggacg      540

cgccgggtgt ggcacagcta gttccgtcgc agccgggatt tgggtcgcgg ttcttgtttg      600

tggatcgctg tgatcgtcac ttggtgagta gcgggctgct gggctggccg gggctttcgt      660

ggccgccggg ccgctcggtg ggacggaagc gtgtggagag accgccaagg gctgtagtct      720

gggtccgcga gcaaggttgc cctgaactgg gggttggggg gagcgcagca aaatggcggc      780

tgttcccgag tcttgaatgg aagacgcttg tgaggcgggc tgtgaggtcg ttgaaacaag      840

gtggggggca tggtgggcgg caagaaccca aggtcttgag gccttcgcta atgcgggaaa      900

gctcttattc gggtgagatg ggctggggca ccatctgggg accctgacgt gaagtttgtc      960

actgactgga gaactcggtt tgtcgtctgt tgcgggggcg gcagttatgg cggtgccgtt     1020

gggcagtgca cccgtacctt tgggagcgcg cgccctcgtc gtgtcgtgac gtcacccgtt     1080

ctgttggctt ataatgcagg gtggggccac ctgccggtag gtgtgcggta ggcttttctc     1140

cgtcgcagga cgcagggttc gggcctaggg taggctctcc tgaatcgaca ggcgccggac     1200

ctctggtgag gggagggata agtgaggcgt cagtttcttt ggtcggtttt atgtacctat     1260

cttcttaagt agctgaagct ccggttttga actatgcgct cggggttggc gagtgtgttt     1320

tgtgaagttt tttaggcacc ttttgaaatg taatcatttg ggtcaatatg taattttcag     1380

tgttagacta gtaaattgtc cgctaaattc tggccgtttt tggctttttt gttagacgaa     1440

gctttattgc ggtagaattc gccgccacc atg aag atc ccc aac atc ggc aac       1493
                                Met Lys Ile Pro Asn Ile Gly Asn           
                                1               5                         

gtg atg aac aag ttc gag atc ctg ggc gtt gtc gga gaa ggc gct tat       1541
Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly Ala Tyr           
    10                  15                  20                            

ggc gtg gtg ctg aag tgc aga cac aaa gaa acc cac gag atc gtg gcc       1589
Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile Val Ala           
25                  30                  35                  40            

atc aag aag ttc aag gac agc gaa gag aac gag gaa gtg aaa gag aca       1637
Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys Glu Thr           
                45                  50                  55                

acc ctg cgc gag ctg aag atg ctg aga acc ctg aag caa gag aac atc       1685
Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu Asn Ile           
            60                  65                  70                    

gtg gaa ctg aaa gag gcc ttc cgg cgg aga ggc aag ctg tac ctg gtg       1733
Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr Leu Val           
        75                  80                  85                        

ttc gag tac gtg gaa aag aac atg ctc gag ctg ctg gaa gag atg ccc       1781
Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu Met Pro           
    90                  95                  100                           

aat ggc gtg cca cct gag aaa gtg aag tcc tac atc tac cag ctg atc       1829
Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln Leu Ile           
105                 110                 115                 120           

aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac aga gac atc       1877
Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg Asp Ile           
                125                 130                 135               

aag ccc gag aac ctg ctg atc tcc cac aac gac gtg ctg aag ctg tgc       1925
Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys Leu Cys           
            140                 145                 150                   

gac ttc ggc ttc gcc aga aat ctg agc gag ggc aac aac gcc aac tac       1973
Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala Asn Tyr           
        155                 160                 165                       

acc gag tat gtg gcc acc aga tgg tac aga agc cct gaa ctg ctg ctg       2021
Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu Leu           
    170                 175                 180                           

gga gcc cct tac ggc aag tct gtg gat atg tgg tcc gtg ggc tgt atc       2069
Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly Cys Ile           
185                 190                 195                 200           

ctg gga gag ctg tct gat ggc caa cct ctg ttt cct ggc gag tcc gag       2117
Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu Ser Glu           
                205                 210                 215               

atc gac cag ctg ttc aca atc cag aag gtg ctg ggc cct ctg cct agc       2165
Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu Pro Ser           
            220                 225                 230                   

gag cag atg aag ctg ttc tac agc aac ccc aga ttc cac ggc ctg aga       2213
Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly Leu Arg           
        235                 240                 245                       

ttc cct gcc gtg aat cac cct cag agc ctg gaa aga aga tac ctg ggc       2261
Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr Leu Gly           
    250                 255                 260                           

atc ctg aac agc gtg ctg ctg gac ctg atg aag aat ctg ctg aaa ctg       2309
Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu Lys Leu           
265                 270                 275                 280           

gac ccc gcc gac aga tac ctg acc gag cag tgt ctg aac cat cct acc       2357
Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His Pro Thr           
                285                 290                 295               

ttt cag acc cag aga ctg ctg gat aga agc ccc agc aga agc gcc aag       2405
Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser Ala Lys           
            300                 305                 310                   

aga aag ccc tac cac gtg gaa agc agc acc ctg agc aat aga aac cag       2453
Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg Asn Gln           
        315                 320                 325                       

gcc gga aag agc act gcc ctg cag agc cac cac aga agc aac agc aag       2501
Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser Lys           
    330                 335                 340                           

gac atc cag aac ctg agc gtg ggc ctg cct aga gct gat gaa gga ctg       2549
Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly Leu           
345                 350                 355                 360           

cct gcc aac gag agc ttc ctg aat gga aat ctg gct ggc gcc tct ctg       2597
Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser Leu           
                365                 370                 375               

agc cct ctg cac aca aag aca tac cag gcc agc agc cag cct ggc agc       2645
Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly Ser           
            380                 385                 390                   

aca agc aag gac ctg acc aac aac aac atc cct cat ctg ctg agc ccc       2693
Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser Pro           
        395                 400                 405                       

aaa gag gcc aag agc aag acc gag ttc gac ttc aac atc gac ccc aag       2741
Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro Lys           
    410                 415                 420                           

cct agc gaa ggc cct ggc acc aag tac ctg aag tcc aac tcc aga agc       2789
Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg Ser           
425                 430                 435                 440           

cag cag aac cgg cac tcc ttc atg gaa agc tct cag agc aag gcc ggc       2837
Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala Gly           
                445                 450                 455               

aca ctg cag cct aac gag aag cag agc aga cac agc tac atc gac aca       2885
Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp Thr           
            460                 465                 470                   

atc cct cag tcc tct cgg agc ccc agc tac aga aca aag gcc aaa tct       2933
Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys Ser           
        475                 480                 485                       

cac ggc gcc ctg agc gat agc aag agc gtg tcc aat ctg tcc gag gct       2981
His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu Ala           
    490                 495                 500                           

aga gcc cag atc gcc gag cct agc acc agc aga tac ttc cct agc agc       3029
Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser Ser           
505                 510                 515                 520           

tgc ctg gat ctg aac agc cct aca agc ccc aca cct acc agg cac agc       3077
Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His Ser           
                525                 530                 535               

gat acc aga aca ctg ctg tcc cca agc ggc cgg aac aac aga aat gag       3125
Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn Glu           
            540                 545                 550                   

ggc acc ctg gac agc aga cgg acc acc aca aga cac agc aag acc atg       3173
Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr Met           
        555                 560                 565                       

gaa gaa ctg aag ctg ccc gag cac atg gac tct agc cac tct cat tct       3221
Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His Ser           
    570                 575                 580                           

ctg agc gcc cct cac gag tcc ttt agc tac ggc ctg ggc tac aca agc       3269
Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr Ser           
585                 590                 595                 600           

cca ttt tcc agt cag cag cgg ccc cac aga cac tct atg tac gtg acc       3317
Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val Thr           
                605                 610                 615               

aga gac aaa gtc cgc gcc aaa ggc ctg gat ggc tct ctg tct att gga       3365
Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile Gly           
            620                 625                 630                   

caa ggc atg gcc gcc aga gcc aat agc ctg caa ctt ctg tct cct cag       3413
Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro Gln           
        635                 640                 645                       

cct ggc gaa cag ctg cct cct gaa atg aca gtg gcc cgg tcc agc gtg       3461
Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser Val           
    650                 655                 660                           

aaa gaa acc agc aga gag ggc acc tcc agc ttc cac acc aga cag aaa       3509
Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln Lys           
665                 670                 675                 680           

agc gaa ggc ggc gtg tac cac gat cct cac tct gat gat ggc aca gcc       3557
Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr Ala           
                685                 690                 695               

cct aaa gag aac aga cac ctg tac aac gac ccc gtg cct aga aga gtg       3605
Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg Arg Val           
            700                 705                 710                   

ggc tcc ttc tac aga gtg cct tct cct aga cct gac aac tcc ttc cac       3653
Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser Phe His           
        715                 720                 725                       

gag aac aac gtg tca acc cgg gtg tcc agc ctg cct tct gag agc agc       3701
Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu Ser Ser           
    730                 735                 740                           

tct ggc aca aac cac tcc aag agg cag ccc gcc ttc gat cct tgg aag       3749
Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro Trp Lys           
745                 750                 755                 760           

tcc cct gag aat atc agc cac tcc gag cag ctg aaa gag aaa gag aag       3797
Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys Glu Lys           
                765                 770                 775               

cag ggc ttt ttc cgg tcc atg aag aag aag aaa aag aag tcc cag aca       3845
Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser Gln Thr           
            780                 785                 790                   

gtc ccc aac agc gac agc cct gat ctc ctg aca ctg cag aag tcc atc       3893
Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser Ile           
        795                 800                 805                       

cac agc gcc agc aca cct agc agc aga cct aaa gag tgg cgg cca gag       3941
His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro Glu           
    810                 815                 820                           

aag atc agc gac ctg caa aca cag agc cag cct ctg aag tcc ctg agg       3989
Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu Arg           
825                 830                 835                 840           

aag ctg ctg cat ctg tcc tcc gcc tct aat cac cct gcc agc agc gat       4037
Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser Ser Asp           
                845                 850                 855               

ccc aga ttt cag cca ctg aca gcc cag cag acc aag aac tcc ttc agc       4085
Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe Ser           
            860                 865                 870                   

gag atc cgg att cac cca ctg tct cag gcc agc ggc ggc agc tct aat       4133
Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser Asn           
        875                 880                 885                       

atc aga caa gag ccc gct cct aag ggc aga cct gct ctc caa ctg cct       4181
Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu Pro           
    890                 895                 900                           

gga cag atg gat cct ggc tgg cac gtg tcc tct gtg aca aga tct gcc       4229
Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg Ser Ala           
905                 910                 915                 920           

acc gag gga cct agc tat tct gag cag ctg ggc gcc aag tct ggc ccc       4277
Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly Pro           
                925                 930                 935               

aat gga cac ccc tac aac cgg acc aat cgg agc aga atg ccc aac ctg       4325
Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro Asn Leu           
            940                 945                 950                   

aac gac ctc aaa gaa aca gcc ctc tga agcttatcga taccggtagt             4372
Asn Asp Leu Lys Glu Thr Ala Leu                                           
        955                 960                                           

gaattctacc agtgccatag gatagtgaat tctaccagtg ccatacacgt gagtgaattc     4432

taccagtgcc atagcatgca gtgaattcta ccagtgccat agcggccgcg atctttttcc     4492

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     4552

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcgatcg     4612

ataaggatct tcctagagca tggctacgta gataagtagc atggcgggtt aatcattaac     4672

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4732

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4792

gagcgagcgc gcagccttaa ttaacctaat tcactggccg tcgttttaca acgtcgtgac     4852

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     4912

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat     4972

ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     5032

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     5092

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     5152

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     5212

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     5272

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     5332

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     5392

caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc     5452

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     5512

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     5572

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     5632

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     5692

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     5752

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     5812

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     5872

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     5932

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     5992

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     6052

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     6112

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     6172

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     6232

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     6292

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     6352

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     6412

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6472

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6532

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6592

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6652

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     6712

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     6772

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     6832

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     6892

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     6952

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     7012

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     7072

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     7132

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     7192

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     7252

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     7312

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     7372

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     7432

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     7492

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     7552

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc agatttaatt     7612

aaggccttaa ttagg                                                      7627


<210>  30
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  30

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210>  31
<211>  7210
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Expression cassette


<220>
<221>  repeat_region
<222>  (1)..(130)
<223>  5' ITR

<220>
<221>  misc_feature
<222>  (130)..(168)
<223>  AAV2 seq upstream of 3' ITR

<220>
<221>  promoter
<222>  (224)..(1021)
<223>  CBh

<220>
<221>  misc_feature
<222>  (801)..(801)
<223>  A deletion

<220>
<221>  CDS
<222>  (1053)..(3935)
<223>  hCDKL5-1

<220>
<221>  misc_feature
<222>  (3936)..(3936)
<223>  Deletion (G)

<220>
<221>  misc_feature
<222>  (3953)..(3974)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (3979)..(4000)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4007)..(4028)
<223>  miRNA183

<220>
<221>  misc_feature
<222>  (4035)..(4056)
<223>  miRNA183

<220>
<221>  polyA_signal
<222>  (4065)..(4191)
<223>  Rabbit Globin PolyA

<220>
<221>  misc_feature
<222>  (4222)..(4260)
<223>  AAV2 seq upstream of 3' ITR

<220>
<221>  repeat_region
<222>  (4260)..(4389)
<223>  3' ITR

<400>  31
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcc tctagaacta tagctagcgc ccttaagggt acccgttaca taacttacgg      240

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca atagtaacgc      300

caatagggac tttccattga cgtcaatggg tggagtattt acggtaaact gcccacttgg      360

cagtacatca agtgtatcat atgccaagta cgccccctat tgacgtcaat gacggtaaat      420

ggcccgcctg gcattgtgcc cagtacatga ccttatggga ctttcctact tggcagtaca      480

tctacgtatt agtcatcgct attaccatgg tcgaggtgag ccccacgttc tgcttcactc      540

tccccatctc ccccccctcc ccacccccaa ttttgtattt atttattttt taattatttt      600

gtgcagcgat gggggcgggg gggggggggg ggcgcgcgcc aggcggggcg gggcggggcg      660

aggggcgggg cggggcgagg cggagaggtg cggcggcagc caatcagagc ggcgcgctcc      720

gaaagtttcc ttttatggcg aggcggcggc ggcggcggcc ctataaaaag cgaagcgcgc      780

ggcgggcggg agtcgctgcg cgctgccttc gccccgtgcc ccgctccgcc gccgcctcgc      840

gccgcccgcc ccggctctga ctgaccgcgt tactcccaca ggtgagcggg cgggacggcc      900

cttctcctcc gggctgtaat tagctgagca agaggtaagg gtttaaggga tggttggttg      960

gtggggtatt aatgtttaat tacctggagc acctgcctga aatcactttt tttcaggttg     1020

gcttaagctg cagaccggaa ttcgccgcca cc atg aag atc ccc aac atc ggc       1073
                                    Met Lys Ile Pro Asn Ile Gly           
                                    1               5                     

aac gtg atg aac aag ttc gag atc ctg ggc gtt gtc gga gaa ggc gct       1121
Asn Val Met Asn Lys Phe Glu Ile Leu Gly Val Val Gly Glu Gly Ala           
        10                  15                  20                        

tat ggc gtg gtg ctg aag tgc aga cac aaa gaa acc cac gag atc gtg       1169
Tyr Gly Val Val Leu Lys Cys Arg His Lys Glu Thr His Glu Ile Val           
    25                  30                  35                            

gcc atc aag aag ttc aag gac agc gaa gag aac gag gaa gtg aaa gag       1217
Ala Ile Lys Lys Phe Lys Asp Ser Glu Glu Asn Glu Glu Val Lys Glu           
40                  45                  50                  55            

aca acc ctg cgc gag ctg aag atg ctg aga acc ctg aag caa gag aac       1265
Thr Thr Leu Arg Glu Leu Lys Met Leu Arg Thr Leu Lys Gln Glu Asn           
                60                  65                  70                

atc gtg gaa ctg aaa gag gcc ttc cgg cgg aga ggc aag ctg tac ctg       1313
Ile Val Glu Leu Lys Glu Ala Phe Arg Arg Arg Gly Lys Leu Tyr Leu           
            75                  80                  85                    

gtg ttc gag tac gtg gaa aag aac atg ctc gag ctg ctg gaa gag atg       1361
Val Phe Glu Tyr Val Glu Lys Asn Met Leu Glu Leu Leu Glu Glu Met           
        90                  95                  100                       

ccc aat ggc gtg cca cct gag aaa gtg aag tcc tac atc tac cag ctg       1409
Pro Asn Gly Val Pro Pro Glu Lys Val Lys Ser Tyr Ile Tyr Gln Leu           
    105                 110                 115                           

atc aag gcc atc cac tgg tgc cac aag aac gac atc gtg cac aga gac       1457
Ile Lys Ala Ile His Trp Cys His Lys Asn Asp Ile Val His Arg Asp           
120                 125                 130                 135           

atc aag ccc gag aac ctg ctg atc tcc cac aac gac gtg ctg aag ctg       1505
Ile Lys Pro Glu Asn Leu Leu Ile Ser His Asn Asp Val Leu Lys Leu           
                140                 145                 150               

tgc gac ttc ggc ttc gcc aga aat ctg agc gag ggc aac aac gcc aac       1553
Cys Asp Phe Gly Phe Ala Arg Asn Leu Ser Glu Gly Asn Asn Ala Asn           
            155                 160                 165                   

tac acc gag tat gtg gcc acc aga tgg tac aga agc cct gaa ctg ctg       1601
Tyr Thr Glu Tyr Val Ala Thr Arg Trp Tyr Arg Ser Pro Glu Leu Leu           
        170                 175                 180                       

ctg gga gcc cct tac ggc aag tct gtg gat atg tgg tcc gtg ggc tgt       1649
Leu Gly Ala Pro Tyr Gly Lys Ser Val Asp Met Trp Ser Val Gly Cys           
    185                 190                 195                           

atc ctg gga gag ctg tct gat ggc caa cct ctg ttt cct ggc gag tcc       1697
Ile Leu Gly Glu Leu Ser Asp Gly Gln Pro Leu Phe Pro Gly Glu Ser           
200                 205                 210                 215           

gag atc gac cag ctg ttc aca atc cag aag gtg ctg ggc cct ctg cct       1745
Glu Ile Asp Gln Leu Phe Thr Ile Gln Lys Val Leu Gly Pro Leu Pro           
                220                 225                 230               

agc gag cag atg aag ctg ttc tac agc aac ccc aga ttc cac ggc ctg       1793
Ser Glu Gln Met Lys Leu Phe Tyr Ser Asn Pro Arg Phe His Gly Leu           
            235                 240                 245                   

aga ttc cct gcc gtg aat cac cct cag agc ctg gaa aga aga tac ctg       1841
Arg Phe Pro Ala Val Asn His Pro Gln Ser Leu Glu Arg Arg Tyr Leu           
        250                 255                 260                       

ggc atc ctg aac agc gtg ctg ctg gac ctg atg aag aat ctg ctg aaa       1889
Gly Ile Leu Asn Ser Val Leu Leu Asp Leu Met Lys Asn Leu Leu Lys           
    265                 270                 275                           

ctg gac ccc gcc gac aga tac ctg acc gag cag tgt ctg aac cat cct       1937
Leu Asp Pro Ala Asp Arg Tyr Leu Thr Glu Gln Cys Leu Asn His Pro           
280                 285                 290                 295           

acc ttt cag acc cag aga ctg ctg gat aga agc ccc agc aga agc gcc       1985
Thr Phe Gln Thr Gln Arg Leu Leu Asp Arg Ser Pro Ser Arg Ser Ala           
                300                 305                 310               

aag aga aag ccc tac cac gtg gaa agc agc acc ctg agc aat aga aac       2033
Lys Arg Lys Pro Tyr His Val Glu Ser Ser Thr Leu Ser Asn Arg Asn           
            315                 320                 325                   

cag gcc gga aag agc act gcc ctg cag agc cac cac aga agc aac agc       2081
Gln Ala Gly Lys Ser Thr Ala Leu Gln Ser His His Arg Ser Asn Ser           
        330                 335                 340                       

aag gac atc cag aac ctg agc gtg ggc ctg cct aga gct gat gaa gga       2129
Lys Asp Ile Gln Asn Leu Ser Val Gly Leu Pro Arg Ala Asp Glu Gly           
    345                 350                 355                           

ctg cct gcc aac gag agc ttc ctg aat gga aat ctg gct ggc gcc tct       2177
Leu Pro Ala Asn Glu Ser Phe Leu Asn Gly Asn Leu Ala Gly Ala Ser           
360                 365                 370                 375           

ctg agc cct ctg cac aca aag aca tac cag gcc agc agc cag cct ggc       2225
Leu Ser Pro Leu His Thr Lys Thr Tyr Gln Ala Ser Ser Gln Pro Gly           
                380                 385                 390               

agc aca agc aag gac ctg acc aac aac aac atc cct cat ctg ctg agc       2273
Ser Thr Ser Lys Asp Leu Thr Asn Asn Asn Ile Pro His Leu Leu Ser           
            395                 400                 405                   

ccc aaa gag gcc aag agc aag acc gag ttc gac ttc aac atc gac ccc       2321
Pro Lys Glu Ala Lys Ser Lys Thr Glu Phe Asp Phe Asn Ile Asp Pro           
        410                 415                 420                       

aag cct agc gaa ggc cct ggc acc aag tac ctg aag tcc aac tcc aga       2369
Lys Pro Ser Glu Gly Pro Gly Thr Lys Tyr Leu Lys Ser Asn Ser Arg           
    425                 430                 435                           

agc cag cag aac cgg cac tcc ttc atg gaa agc tct cag agc aag gcc       2417
Ser Gln Gln Asn Arg His Ser Phe Met Glu Ser Ser Gln Ser Lys Ala           
440                 445                 450                 455           

ggc aca ctg cag cct aac gag aag cag agc aga cac agc tac atc gac       2465
Gly Thr Leu Gln Pro Asn Glu Lys Gln Ser Arg His Ser Tyr Ile Asp           
                460                 465                 470               

aca atc cct cag tcc tct cgg agc ccc agc tac aga aca aag gcc aaa       2513
Thr Ile Pro Gln Ser Ser Arg Ser Pro Ser Tyr Arg Thr Lys Ala Lys           
            475                 480                 485                   

tct cac ggc gcc ctg agc gat agc aag agc gtg tcc aat ctg tcc gag       2561
Ser His Gly Ala Leu Ser Asp Ser Lys Ser Val Ser Asn Leu Ser Glu           
        490                 495                 500                       

gct aga gcc cag atc gcc gag cct agc acc agc aga tac ttc cct agc       2609
Ala Arg Ala Gln Ile Ala Glu Pro Ser Thr Ser Arg Tyr Phe Pro Ser           
    505                 510                 515                           

agc tgc ctg gat ctg aac agc cct aca agc ccc aca cct acc agg cac       2657
Ser Cys Leu Asp Leu Asn Ser Pro Thr Ser Pro Thr Pro Thr Arg His           
520                 525                 530                 535           

agc gat acc aga aca ctg ctg tcc cca agc ggc cgg aac aac aga aat       2705
Ser Asp Thr Arg Thr Leu Leu Ser Pro Ser Gly Arg Asn Asn Arg Asn           
                540                 545                 550               

gag ggc acc ctg gac agc aga cgg acc acc aca aga cac agc aag acc       2753
Glu Gly Thr Leu Asp Ser Arg Arg Thr Thr Thr Arg His Ser Lys Thr           
            555                 560                 565                   

atg gaa gaa ctg aag ctg ccc gag cac atg gac tct agc cac tct cat       2801
Met Glu Glu Leu Lys Leu Pro Glu His Met Asp Ser Ser His Ser His           
        570                 575                 580                       

tct ctg agc gcc cct cac gag tcc ttt agc tac ggc ctg ggc tac aca       2849
Ser Leu Ser Ala Pro His Glu Ser Phe Ser Tyr Gly Leu Gly Tyr Thr           
    585                 590                 595                           

agc cca ttt tcc agt cag cag cgg ccc cac aga cac tct atg tac gtg       2897
Ser Pro Phe Ser Ser Gln Gln Arg Pro His Arg His Ser Met Tyr Val           
600                 605                 610                 615           

acc aga gac aaa gtc cgc gcc aaa ggc ctg gat ggc tct ctg tct att       2945
Thr Arg Asp Lys Val Arg Ala Lys Gly Leu Asp Gly Ser Leu Ser Ile           
                620                 625                 630               

gga caa ggc atg gcc gcc aga gcc aat agc ctg caa ctt ctg tct cct       2993
Gly Gln Gly Met Ala Ala Arg Ala Asn Ser Leu Gln Leu Leu Ser Pro           
            635                 640                 645                   

cag cct ggc gaa cag ctg cct cct gaa atg aca gtg gcc cgg tcc agc       3041
Gln Pro Gly Glu Gln Leu Pro Pro Glu Met Thr Val Ala Arg Ser Ser           
        650                 655                 660                       

gtg aaa gaa acc agc aga gag ggc acc tcc agc ttc cac acc aga cag       3089
Val Lys Glu Thr Ser Arg Glu Gly Thr Ser Ser Phe His Thr Arg Gln           
    665                 670                 675                           

aaa agc gaa ggc ggc gtg tac cac gat cct cac tct gat gat ggc aca       3137
Lys Ser Glu Gly Gly Val Tyr His Asp Pro His Ser Asp Asp Gly Thr           
680                 685                 690                 695           

gcc cct aaa gag aac aga cac ctg tac aac gac ccc gtg cct aga aga       3185
Ala Pro Lys Glu Asn Arg His Leu Tyr Asn Asp Pro Val Pro Arg Arg           
                700                 705                 710               

gtg ggc tcc ttc tac aga gtg cct tct cct aga cct gac aac tcc ttc       3233
Val Gly Ser Phe Tyr Arg Val Pro Ser Pro Arg Pro Asp Asn Ser Phe           
            715                 720                 725                   

cac gag aac aac gtg tca acc cgg gtg tcc agc ctg cct tct gag agc       3281
His Glu Asn Asn Val Ser Thr Arg Val Ser Ser Leu Pro Ser Glu Ser           
        730                 735                 740                       

agc tct ggc aca aac cac tcc aag agg cag ccc gcc ttc gat cct tgg       3329
Ser Ser Gly Thr Asn His Ser Lys Arg Gln Pro Ala Phe Asp Pro Trp           
    745                 750                 755                           

aag tcc cct gag aat atc agc cac tcc gag cag ctg aaa gag aaa gag       3377
Lys Ser Pro Glu Asn Ile Ser His Ser Glu Gln Leu Lys Glu Lys Glu           
760                 765                 770                 775           

aag cag ggc ttt ttc cgg tcc atg aag aag aag aaa aag aag tcc cag       3425
Lys Gln Gly Phe Phe Arg Ser Met Lys Lys Lys Lys Lys Lys Ser Gln           
                780                 785                 790               

aca gtc ccc aac agc gac agc cct gat ctc ctg aca ctg cag aag tcc       3473
Thr Val Pro Asn Ser Asp Ser Pro Asp Leu Leu Thr Leu Gln Lys Ser           
            795                 800                 805                   

atc cac agc gcc agc aca cct agc agc aga cct aaa gag tgg cgg cca       3521
Ile His Ser Ala Ser Thr Pro Ser Ser Arg Pro Lys Glu Trp Arg Pro           
        810                 815                 820                       

gag aag atc agc gac ctg caa aca cag agc cag cct ctg aag tcc ctg       3569
Glu Lys Ile Ser Asp Leu Gln Thr Gln Ser Gln Pro Leu Lys Ser Leu           
    825                 830                 835                           

agg aag ctg ctg cat ctg tcc tcc gcc tct aat cac cct gcc agc agc       3617
Arg Lys Leu Leu His Leu Ser Ser Ala Ser Asn His Pro Ala Ser Ser           
840                 845                 850                 855           

gat ccc aga ttt cag cca ctg aca gcc cag cag acc aag aac tcc ttc       3665
Asp Pro Arg Phe Gln Pro Leu Thr Ala Gln Gln Thr Lys Asn Ser Phe           
                860                 865                 870               

agc gag atc cgg att cac cca ctg tct cag gcc agc ggc ggc agc tct       3713
Ser Glu Ile Arg Ile His Pro Leu Ser Gln Ala Ser Gly Gly Ser Ser           
            875                 880                 885                   

aat atc aga caa gag ccc gct cct aag ggc aga cct gct ctc caa ctg       3761
Asn Ile Arg Gln Glu Pro Ala Pro Lys Gly Arg Pro Ala Leu Gln Leu           
        890                 895                 900                       

cct gga cag atg gat cct ggc tgg cac gtg tcc tct gtg aca aga tct       3809
Pro Gly Gln Met Asp Pro Gly Trp His Val Ser Ser Val Thr Arg Ser           
    905                 910                 915                           

gcc acc gag gga cct agc tat tct gag cag ctg ggc gcc aag tct ggc       3857
Ala Thr Glu Gly Pro Ser Tyr Ser Glu Gln Leu Gly Ala Lys Ser Gly           
920                 925                 930                 935           

ccc aat gga cac ccc tac aac cgg acc aat cgg agc aga atg ccc aac       3905
Pro Asn Gly His Pro Tyr Asn Arg Thr Asn Arg Ser Arg Met Pro Asn           
                940                 945                 950               

ctg aac gac ctc aaa gaa aca gcc ctc tga agcttatcga taccggtagt         3955
Leu Asn Asp Leu Lys Glu Thr Ala Leu                                       
            955                 960                                       

gaattctacc agtgccatag gatagtgaat tctaccagtg ccatacacgt gagtgaattc     4015

taccagtgcc atagcatgca gtgaattcta ccagtgccat agcggccgcg atctttttcc     4075

ctctgccaaa aattatgggg acatcatgaa gccccttgag catctgactt ctggctaata     4135

aaggaaattt attttcattg caatagtgtg ttggaatttt ttgtgtctct cactcgatcg     4195

ataaggatct tcctagagca tggctacgta gataagtagc atggcgggtt aatcattaac     4255

tacaaggaac ccctagtgat ggagttggcc actccctctc tgcgcgctcg ctcgctcact     4315

gaggccgggc gaccaaaggt cgcccgacgc ccgggctttg cccgggcggc ctcagtgagc     4375

gagcgagcgc gcagccttaa ttaacctaat tcactggccg tcgttttaca acgtcgtgac     4435

tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc tttcgccagc     4495

tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg cagcctgaat     4555

ggcgaatggg acgcgccctg tagcggcgca ttaagcgcgg cgggtgtggt ggttacgcgc     4615

agcgtgaccg ctacacttgc cagcgcccta gcgcccgctc ctttcgcttt cttcccttcc     4675

tttctcgcca cgttcgccgg ctttccccgt caagctctaa atcgggggct ccctttaggg     4735

ttccgattta gtgctttacg gcacctcgac cccaaaaaac ttgattaggg tgatggttca     4795

cgtagtgggc catcgccctg atagacggtt tttcgccctt tgacgttgga gtccacgttc     4855

tttaatagtg gactcttgtt ccaaactgga acaacactca accctatctc ggtctattct     4915

tttgatttat aagggatttt gccgatttcg gcctattggt taaaaaatga gctgatttaa     4975

caaaaattta acgcgaattt taacaaaata ttaacgctta caatttaggt ggcacttttc     5035

ggggaaatgt gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc     5095

cgctcatgag acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga     5155

gtattcaaca tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt     5215

ttgctcaccc agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag     5275

tgggttacat cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag     5335

aacgttttcc aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta     5395

ttgacgccgg gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg     5455

agtactcacc agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca     5515

gtgctgccat aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag     5575

gaccgaagga gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc     5635

gttgggaacc ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg     5695

tagcaatggc aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc     5755

ggcaacaatt aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg     5815

cccttccggc tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg     5875

gtatcattgc agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga     5935

cggggagtca ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac     5995

tgattaagca ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa     6055

aacttcattt ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca     6115

aaatccctta acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag     6175

gatcttcttg agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac     6235

cgctaccagc ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa     6295

ctggcttcag cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc     6355

accacttcaa gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag     6415

tggctgctgc cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac     6475

cggataaggc gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc     6535

gaacgaccta caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc     6595

ccgaagggag aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca     6655

cgagggagct tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc     6715

tctgacttga gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg     6775

ccagcaacgc ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct     6835

ttcctgcgtt atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata     6895

ccgctcgccg cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc     6955

gcccaatacg caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg     7015

acaggtttcc cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca     7075

ctcattaggc accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg     7135

tgagcggata acaatttcac acaggaaaca gctatgacca tgattacgcc agatttaatt     7195

aaggccttaa ttagg                                                      7210


<210>  32
<211>  960
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  32

Met Lys Ile Pro Asn Ile Gly Asn Val Met Asn Lys Phe Glu Ile Leu 
1               5                   10                  15      


Gly Val Val Gly Glu Gly Ala Tyr Gly Val Val Leu Lys Cys Arg His 
            20                  25                  30          


Lys Glu Thr His Glu Ile Val Ala Ile Lys Lys Phe Lys Asp Ser Glu 
        35                  40                  45              


Glu Asn Glu Glu Val Lys Glu Thr Thr Leu Arg Glu Leu Lys Met Leu 
    50                  55                  60                  


Arg Thr Leu Lys Gln Glu Asn Ile Val Glu Leu Lys Glu Ala Phe Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Leu Tyr Leu Val Phe Glu Tyr Val Glu Lys Asn Met 
                85                  90                  95      


Leu Glu Leu Leu Glu Glu Met Pro Asn Gly Val Pro Pro Glu Lys Val 
            100                 105                 110         


Lys Ser Tyr Ile Tyr Gln Leu Ile Lys Ala Ile His Trp Cys His Lys 
        115                 120                 125             


Asn Asp Ile Val His Arg Asp Ile Lys Pro Glu Asn Leu Leu Ile Ser 
    130                 135                 140                 


His Asn Asp Val Leu Lys Leu Cys Asp Phe Gly Phe Ala Arg Asn Leu 
145                 150                 155                 160 


Ser Glu Gly Asn Asn Ala Asn Tyr Thr Glu Tyr Val Ala Thr Arg Trp 
                165                 170                 175     


Tyr Arg Ser Pro Glu Leu Leu Leu Gly Ala Pro Tyr Gly Lys Ser Val 
            180                 185                 190         


Asp Met Trp Ser Val Gly Cys Ile Leu Gly Glu Leu Ser Asp Gly Gln 
        195                 200                 205             


Pro Leu Phe Pro Gly Glu Ser Glu Ile Asp Gln Leu Phe Thr Ile Gln 
    210                 215                 220                 


Lys Val Leu Gly Pro Leu Pro Ser Glu Gln Met Lys Leu Phe Tyr Ser 
225                 230                 235                 240 


Asn Pro Arg Phe His Gly Leu Arg Phe Pro Ala Val Asn His Pro Gln 
                245                 250                 255     


Ser Leu Glu Arg Arg Tyr Leu Gly Ile Leu Asn Ser Val Leu Leu Asp 
            260                 265                 270         


Leu Met Lys Asn Leu Leu Lys Leu Asp Pro Ala Asp Arg Tyr Leu Thr 
        275                 280                 285             


Glu Gln Cys Leu Asn His Pro Thr Phe Gln Thr Gln Arg Leu Leu Asp 
    290                 295                 300                 


Arg Ser Pro Ser Arg Ser Ala Lys Arg Lys Pro Tyr His Val Glu Ser 
305                 310                 315                 320 


Ser Thr Leu Ser Asn Arg Asn Gln Ala Gly Lys Ser Thr Ala Leu Gln 
                325                 330                 335     


Ser His His Arg Ser Asn Ser Lys Asp Ile Gln Asn Leu Ser Val Gly 
            340                 345                 350         


Leu Pro Arg Ala Asp Glu Gly Leu Pro Ala Asn Glu Ser Phe Leu Asn 
        355                 360                 365             


Gly Asn Leu Ala Gly Ala Ser Leu Ser Pro Leu His Thr Lys Thr Tyr 
    370                 375                 380                 


Gln Ala Ser Ser Gln Pro Gly Ser Thr Ser Lys Asp Leu Thr Asn Asn 
385                 390                 395                 400 


Asn Ile Pro His Leu Leu Ser Pro Lys Glu Ala Lys Ser Lys Thr Glu 
                405                 410                 415     


Phe Asp Phe Asn Ile Asp Pro Lys Pro Ser Glu Gly Pro Gly Thr Lys 
            420                 425                 430         


Tyr Leu Lys Ser Asn Ser Arg Ser Gln Gln Asn Arg His Ser Phe Met 
        435                 440                 445             


Glu Ser Ser Gln Ser Lys Ala Gly Thr Leu Gln Pro Asn Glu Lys Gln 
    450                 455                 460                 


Ser Arg His Ser Tyr Ile Asp Thr Ile Pro Gln Ser Ser Arg Ser Pro 
465                 470                 475                 480 


Ser Tyr Arg Thr Lys Ala Lys Ser His Gly Ala Leu Ser Asp Ser Lys 
                485                 490                 495     


Ser Val Ser Asn Leu Ser Glu Ala Arg Ala Gln Ile Ala Glu Pro Ser 
            500                 505                 510         


Thr Ser Arg Tyr Phe Pro Ser Ser Cys Leu Asp Leu Asn Ser Pro Thr 
        515                 520                 525             


Ser Pro Thr Pro Thr Arg His Ser Asp Thr Arg Thr Leu Leu Ser Pro 
    530                 535                 540                 


Ser Gly Arg Asn Asn Arg Asn Glu Gly Thr Leu Asp Ser Arg Arg Thr 
545                 550                 555                 560 


Thr Thr Arg His Ser Lys Thr Met Glu Glu Leu Lys Leu Pro Glu His 
                565                 570                 575     


Met Asp Ser Ser His Ser His Ser Leu Ser Ala Pro His Glu Ser Phe 
            580                 585                 590         


Ser Tyr Gly Leu Gly Tyr Thr Ser Pro Phe Ser Ser Gln Gln Arg Pro 
        595                 600                 605             


His Arg His Ser Met Tyr Val Thr Arg Asp Lys Val Arg Ala Lys Gly 
    610                 615                 620                 


Leu Asp Gly Ser Leu Ser Ile Gly Gln Gly Met Ala Ala Arg Ala Asn 
625                 630                 635                 640 


Ser Leu Gln Leu Leu Ser Pro Gln Pro Gly Glu Gln Leu Pro Pro Glu 
                645                 650                 655     


Met Thr Val Ala Arg Ser Ser Val Lys Glu Thr Ser Arg Glu Gly Thr 
            660                 665                 670         


Ser Ser Phe His Thr Arg Gln Lys Ser Glu Gly Gly Val Tyr His Asp 
        675                 680                 685             


Pro His Ser Asp Asp Gly Thr Ala Pro Lys Glu Asn Arg His Leu Tyr 
    690                 695                 700                 


Asn Asp Pro Val Pro Arg Arg Val Gly Ser Phe Tyr Arg Val Pro Ser 
705                 710                 715                 720 


Pro Arg Pro Asp Asn Ser Phe His Glu Asn Asn Val Ser Thr Arg Val 
                725                 730                 735     


Ser Ser Leu Pro Ser Glu Ser Ser Ser Gly Thr Asn His Ser Lys Arg 
            740                 745                 750         


Gln Pro Ala Phe Asp Pro Trp Lys Ser Pro Glu Asn Ile Ser His Ser 
        755                 760                 765             


Glu Gln Leu Lys Glu Lys Glu Lys Gln Gly Phe Phe Arg Ser Met Lys 
    770                 775                 780                 


Lys Lys Lys Lys Lys Ser Gln Thr Val Pro Asn Ser Asp Ser Pro Asp 
785                 790                 795                 800 


Leu Leu Thr Leu Gln Lys Ser Ile His Ser Ala Ser Thr Pro Ser Ser 
                805                 810                 815     


Arg Pro Lys Glu Trp Arg Pro Glu Lys Ile Ser Asp Leu Gln Thr Gln 
            820                 825                 830         


Ser Gln Pro Leu Lys Ser Leu Arg Lys Leu Leu His Leu Ser Ser Ala 
        835                 840                 845             


Ser Asn His Pro Ala Ser Ser Asp Pro Arg Phe Gln Pro Leu Thr Ala 
    850                 855                 860                 


Gln Gln Thr Lys Asn Ser Phe Ser Glu Ile Arg Ile His Pro Leu Ser 
865                 870                 875                 880 


Gln Ala Ser Gly Gly Ser Ser Asn Ile Arg Gln Glu Pro Ala Pro Lys 
                885                 890                 895     


Gly Arg Pro Ala Leu Gln Leu Pro Gly Gln Met Asp Pro Gly Trp His 
            900                 905                 910         


Val Ser Ser Val Thr Arg Ser Ala Thr Glu Gly Pro Ser Tyr Ser Glu 
        915                 920                 925             


Gln Leu Gly Ala Lys Ser Gly Pro Asn Gly His Pro Tyr Asn Arg Thr 
    930                 935                 940                 


Asn Arg Ser Arg Met Pro Asn Leu Asn Asp Leu Lys Glu Thr Ala Leu 
945                 950                 955                 960 


<210>  33
<211>  2211
<212>  DNA
<213>  adeno-associated virus rh91


<220>
<221>  CDS
<222>  (1)..(2211)
<223>  AAVrh.91

<400>  33
atg gct gcc gat ggt tat ctt cca gat tgg ctc gag gac aac ctc tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gag ggc att cgc gag tgg tgg gcg ctg aaa cct gga gcc ccg aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcc aac cag caa aag cag gac gac ggc cgg ggt ctg gtg ctt cct        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggc tac aag tac ctc gga ccc ttc aac gga ctc gac aag ggg gag ccc        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gca gcg gcc ctc gag cac gac aag gcc tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aaa gcg ggt gac aat ccg tac ctg cgg tat aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctg caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctc ggg cga gca gtc ttc cag gcc aag aag cgg gtt ctc gaa cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa gca gct aag acg gct cct gga aag aaa cgt        432
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

ccg gta gag cag tcg ccc caa gaa cca gac tcc tcc tcg ggc att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aaa tca ggc cag cag ccc gcc aaa aag aga ctc aat ttc ggt cag act        528
Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gaa acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctt cct acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agc gct tca acg ggg gcc agt aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tca cca cgt gac tgg cag cga ctc att aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aag ctc ttc aac atc cag        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtg ttc tcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggt tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gta ttc atg att cct cag tac ggc tac cta acg ctc aac aat ggc       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agc cag gcc gta gga cgt tca tcc ttt tat tgc ctg gaa tat ttc cca       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tct caa atg ctg aga acg ggc aac aac ttt acc ttc agc tac acc ttt       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gaa gat gtg cct ttc cac agc agt tac gcg cac agc cag agc ctg gac       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

agg cta atg aat cct cta atc gac cag tac ctg tat tac cta aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

act cag aat caa tcc gga agt gca caa aac aag gac ttg ctg ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgg ggg tct cca gct ggc atg tct gtt cag ccc aaa aac tgg cta ccc       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

ggg ccc tgt tac cga cag cag cgt gtt tct aaa aca aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agc aac ttt acc tgg act ggt gcc tcc aaa tac aat ctg aac       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

gga cgt gaa tcc atc att aac cct ggc acc gct atg gca tcc cac aag       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gac gaa gac aaa ttt ttt ccc atg agc ggt gtt atg att ttt ggc       1632
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aaa gaa aat gca gga gca tca aac act gca tta gac aat gtt atg att       1680
Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

aca gat gaa gag gaa att aaa gct acc aac ccc gtg gcc acc gag aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt gga act gtg gca gtc aat ctc caa agc agc aat aca gac cct gca       1776
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala           
            580                 585                 590                   

aca gga gac gtg cat gtc atg ggg gct tta cct ggc atg gtg tgg caa       1824
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gac aga gac gtg tac ctg cag ggt ccc att tgg gcc aag att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gat gga cac ttt cac ccg tct cct ctt atg ggc ggc ttt gga ctt       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aag cac ccg cct cct cag atc ctc atc aaa aac acg cct gtt cct gcg       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gca gag ttt tcg gct aca aag ttt gct tca ttc atc acc       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

cag tac tcc aca gga caa gtg agc gtg gaa att gaa tgg gag ctg cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agt aag cgc tgg aat cct gaa gtg cag tac acc tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tac gcg aaa tct gcc aac gtt gat ttc act gtg gac aac aat gga ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gag cct cgc ccc att ggc acc cgt tac ctt acc cgt ccc ctt       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               

taa                                                                   2211


<210>  34
<211>  736
<212>  PRT
<213>  adeno-associated virus rh91

<400>  34

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  35
<211>  2211
<212>  DNA
<213>  adeno-associated virus rh91


<220>
<221>  CDS
<222>  (1)..(2211)
<223>  AAVrh.91

<400>  35
atg gct gct gac ggt tat ctt cca gat tgg ctc gag gac aac ctt tct         48
Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser           
1               5                   10                  15                

gaa ggc att cgt gag tgg tgg gct ctg aaa cct gga gcc cct aaa ccc         96
Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro           
            20                  25                  30                    

aaa gcg aac caa caa aag cag gac gac ggc cgg ggt ctt gtg ctt ccg        144
Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro           
        35                  40                  45                        

ggt tac aaa tac ctc gga ccc ttc aac gga ctc gac aaa gga gag ccg        192
Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro           
    50                  55                  60                            

gtc aac gcg gcg gac gcg gca gcc ctc gaa cac gac aaa gct tac gac        240
Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp           
65                  70                  75                  80            

cag cag ctc aag gcc ggt gac aac ccg tac ctc cgg tac aac cac gcc        288
Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala           
                85                  90                  95                

gac gcc gag ttt cag gag cgt ctt caa gaa gat acg tct ttt ggg ggc        336
Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly           
            100                 105                 110                   

aac ctt ggc aga gca gtc ttc cag gcc aaa aag agg gtt ctt gag cct        384
Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro           
        115                 120                 125                       

ttt ggt ctg gtt gag gaa gca gct aaa acg gct cct gga aag aag agg        432
Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg           
    130                 135                 140                           

cct gta gag cag tct cct cag gaa ccg gac tca tca tct ggt att ggc        480
Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly           
145                 150                 155                 160           

aaa tcg ggc cag cag cct gcc aaa aaa aga cta aat ttc ggt cag act        528
Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr           
                165                 170                 175               

ggc gac tca gag tca gtc ccc gac cct caa cct ctc gga gaa cct cca        576
Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro           
            180                 185                 190                   

gaa acc ccc gct gct gtg gga cct act aca atg gct tca ggc ggt ggc        624
Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly           
        195                 200                 205                       

gca cca atg gca gac aat aac gaa ggc gcc gac gga gtg ggt aat gcc        672
Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala           
    210                 215                 220                           

tca gga aat tgg cat tgc gat tcc aca tgg ctg ggc gac aga gtc atc        720
Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile           
225                 230                 235                 240           

acc acc agc acc cga acc tgg gcc ctt cct acc tac aac aac cac ctc        768
Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu           
                245                 250                 255               

tac aag caa atc tcc agc gct tca acg ggg gcc agt aac gac aac cac        816
Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His           
            260                 265                 270                   

tac ttt ggc tac agc acc ccc tgg ggg tat ttt gat ttc aac aga ttc        864
Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe           
        275                 280                 285                       

cac tgc cac ttc tca cca cgt gac tgg cag cga ctc att aac aac aac        912
His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn           
    290                 295                 300                           

tgg gga ttc cgg ccc aag aga ctc aac ttc aag ctc ttc aac atc cag        960
Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln           
305                 310                 315                 320           

gtc aag gag gtc acg acg aat gat ggc gtc aca acc atc gct aat aac       1008
Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn           
                325                 330                 335               

ctt acc agc acg gtt caa gtg ttc tcg gac tcg gag tac cag ctg ccg       1056
Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro           
            340                 345                 350                   

tac gtc ctc ggt tct gcg cac cag ggc tgc ctc cct ccg ttc ccg gcg       1104
Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala           
        355                 360                 365                       

gac gta ttc atg att cct cag tat gga tac ctc acc ctg aac aac gga       1152
Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly           
    370                 375                 380                           

agt caa gcg gtg gga cgc tca tcc ttt tac tgc ctg gag tac ttc cct       1200
Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro           
385                 390                 395                 400           

tcg cag atg cta agg act gga aat aac ttc acc ttc agc tat acc ttc       1248
Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe           
                405                 410                 415               

gag gat gta cct ttt cac agc agc tac gct cac agc cag agt ttg gat       1296
Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp           
            420                 425                 430                   

cgc ttg atg aat cct ctt att gat cag tat ctg tac tac ctg aac aga       1344
Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg           
        435                 440                 445                       

acg caa aat caa tct gga agt gca caa aac aag gac ctg ctt ttt agc       1392
Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser           
    450                 455                 460                           

cgg ggg tct cct gct ggc atg tct gtt cag ccc aaa aat tgg cta cct       1440
Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro           
465                 470                 475                 480           

ggg ccc tgc tac cgg caa cag aga gtt tca aag act aaa aca gac aac       1488
Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn           
                485                 490                 495               

aac aac agt aac ttt acc tgg aca ggt gcc agc aaa tat aat ctc aat       1536
Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn           
            500                 505                 510                   

ggc cgc gaa tcg atc att aat cca gga acc gct atg gcc agt cac aag       1584
Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys           
        515                 520                 525                       

gac gat gaa gac aaa ttt ttc cct atg agc ggc gtt atg ata ttt ggc       1632
Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly           
    530                 535                 540                           

aaa gaa aat gca gga gca agt aac act gca tta gat aat gta atg att       1680
Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile           
545                 550                 555                 560           

acg gat gaa gaa gag att aaa gct acc aat cct gtg gca aca gag aga       1728
Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg           
                565                 570                 575               

ttt gga act gtg gca gtc aac ttg cag agc tca aat aca gac ccc gca       1776
Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala           
            580                 585                 590                   

act gga gac gtc cat gtc atg ggg gcc tta cct ggc atg gtg tgg caa       1824
Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln           
        595                 600                 605                       

gat cgt gac gtg tac ctt caa gga cct atc tgg gca aag att cct cac       1872
Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His           
    610                 615                 620                           

acg gat gga cac ttt cat cct tct cct ctg atg gga ggc ttt gga ctg       1920
Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu           
625                 630                 635                 640           

aaa cat ccg cct cct caa atc ctc atc aaa aat act ccg gta ccg gca       1968
Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala           
                645                 650                 655               

aat cct ccg gca gag ttc agc gct aca aag ttt gct tca ttt atc act       2016
Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr           
            660                 665                 670                   

cag tac tcc act gga cag gtc agc gtg gaa att gag tgg gag cta cag       2064
Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln           
        675                 680                 685                       

aaa gaa aac agc aaa cgt tgg aat cca gag gtg cag tac act tcc aac       2112
Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn           
    690                 695                 700                           

tac gcg aag tct gcc aat gtg gac ttt act gta gac aac aat ggt ctt       2160
Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu           
705                 710                 715                 720           

tat act gaa cct cgc cct att gga acc cgg tat ctc aca cga ccc ttg       2208
Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu           
                725                 730                 735               

taa                                                                   2211


<210>  36
<211>  736
<212>  PRT
<213>  adeno-associated virus rh91

<400>  36

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Lys Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Phe Gly Leu Val Glu Glu Ala Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Gln Ser Pro Gln Glu Pro Asp Ser Ser Ser Gly Ile Gly 
145                 150                 155                 160 


Lys Ser Gly Gln Gln Pro Ala Lys Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro Pro 
            180                 185                 190         


Glu Thr Pro Ala Ala Val Gly Pro Thr Thr Met Ala Ser Gly Gly Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ala 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His 
            260                 265                 270         


Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe 
        275                 280                 285             


His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn 
    290                 295                 300                 


Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln 
305                 310                 315                 320 


Val Lys Glu Val Thr Thr Asn Asp Gly Val Thr Thr Ile Ala Asn Asn 
                325                 330                 335     


Leu Thr Ser Thr Val Gln Val Phe Ser Asp Ser Glu Tyr Gln Leu Pro 
            340                 345                 350         


Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala 
        355                 360                 365             


Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly 
    370                 375                 380                 


Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro 
385                 390                 395                 400 


Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe 
                405                 410                 415     


Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp 
            420                 425                 430         


Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Asn Arg 
        435                 440                 445             


Thr Gln Asn Gln Ser Gly Ser Ala Gln Asn Lys Asp Leu Leu Phe Ser 
    450                 455                 460                 


Arg Gly Ser Pro Ala Gly Met Ser Val Gln Pro Lys Asn Trp Leu Pro 
465                 470                 475                 480 


Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Lys Thr Asp Asn 
                485                 490                 495     


Asn Asn Ser Asn Phe Thr Trp Thr Gly Ala Ser Lys Tyr Asn Leu Asn 
            500                 505                 510         


Gly Arg Glu Ser Ile Ile Asn Pro Gly Thr Ala Met Ala Ser His Lys 
        515                 520                 525             


Asp Asp Glu Asp Lys Phe Phe Pro Met Ser Gly Val Met Ile Phe Gly 
    530                 535                 540                 


Lys Glu Asn Ala Gly Ala Ser Asn Thr Ala Leu Asp Asn Val Met Ile 
545                 550                 555                 560 


Thr Asp Glu Glu Glu Ile Lys Ala Thr Asn Pro Val Ala Thr Glu Arg 
                565                 570                 575     


Phe Gly Thr Val Ala Val Asn Leu Gln Ser Ser Asn Thr Asp Pro Ala 
            580                 585                 590         


Thr Gly Asp Val His Val Met Gly Ala Leu Pro Gly Met Val Trp Gln 
        595                 600                 605             


Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His 
    610                 615                 620                 


Thr Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu 
625                 630                 635                 640 


Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala 
                645                 650                 655     


Asn Pro Pro Ala Glu Phe Ser Ala Thr Lys Phe Ala Ser Phe Ile Thr 
            660                 665                 670         


Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln 
        675                 680                 685             


Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Val Gln Tyr Thr Ser Asn 
    690                 695                 700                 


Tyr Ala Lys Ser Ala Asn Val Asp Phe Thr Val Asp Asn Asn Gly Leu 
705                 710                 715                 720 


Tyr Thr Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Pro Leu 
                725                 730                 735     


<210>  37
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5co-A

<400>  37
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtggtgggc       60

gagggcgcct acggcgtggt gctgaagtgc aggcacaagg agacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaggagaac gaggaggtga aggagaccac cctgagggag      180

ctgaagatgc tgaggaccct gaagcaggag aacatcgtgg agctgaagga ggccttcagg      240

aggaggggca agctgtacct ggtgttcgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ccaacggcgt gccccccgag aaggtgaaga gctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gggacatcaa gcccgagaac      420

ctgctgatca gccacaacga cgtgctgaag ctgtgcgact tcggcttcgc caggaacctg      480

agcgagggca acaacgccaa ctacaccgag tacgtggcca ccaggtggta caggagcccc      540

gagctgctgc tgggcgcccc ctacggcaag agcgtggaca tgtggagcgt gggctgcatc      600

ctgggcgagc tgagcgacgg ccagcccctg ttccccggcg agagcgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccccctg cccagcgagc agatgaagct gttctacagc      720

aaccccaggt tccacggcct gaggttcccc gccgtgaacc acccccagag cctggagagg      780

aggtacttgg gcatcctgaa cagcgtgctg ctggacctga tgaagaacct gctgaagctg      840

gaccccgccg acaggtactt gaccgagcag tgcctgaacc accccacctt ccagacccag      900

aggctgctgg acaggagccc cagcaggagc gccaagagga agccctacca cgtggagagc      960

agcaccctga gcaacaggaa ccaggccggc aagagcaccg ccctgcagag ccaccacagg     1020

agcaacagca aggacatcca gaacctgagc gtgggcctgc ccagggccga cgagggcctg     1080

cccgccaacg agagcttcct gaacggcaac ctggccggcg ccagcctgag ccccctgcac     1140

accaagacct accaggccag cagccagccc ggcagcacca gcaaggacct gaccaacaac     1200

aacatccccc acctgctgag ccccaaggag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcccagcga gggccccggc accaagtacc tgaagagcaa cagcaggagc     1320

cagcagaaca ggcacagctt catggagagc agccagagca aggccggcac cctgcagccc     1380

aacgagaagc agagcaggca cagctacatc gacaccatcc cccagagcag caggagcccc     1440

agctacagga ccaaggccaa gagccacggc gccctgagcg acagcaagag cgtgagcaac     1500

ctgagcgagg ccagggccca gatcgccgag cccagcacca gcaggtactt ccccagcagc     1560

tgcctggacc tgaacagccc caccagcccc acccccacca ggcacagcga caccaggacc     1620

ctgctgagcc ccagcggcag gaacaacagg aacgagggca ccctggacag caggaggacc     1680

accaccaggc acagcaagac catggaggag ctgaagctgc ccgagcacat ggacagcagc     1740

cacagccaca gcctgagcgc cccccacgag agcttcagct acggcctggg ctacaccagc     1800

cccttcagca gccagcagag gccccacagg cacagcatgt acgtgaccag ggacaaggtg     1860

agggccaagg gcctggacgg cagcctgagc atcggccagg gcatggccgc cagggccaac     1920

agcctgcagc tgctgagccc ccagcccggc gagcagctgc cccccgagat gaccgtggcc     1980

aggagcagcg tgaaggagac cagcagggag ggcaccagca gcttccacac caggcagaag     2040

agcgagggcg gcgtgtacca cgacccccac agcgacgacg gcaccgcccc caaggagaac     2100

aggcacctgt acaacgaccc cgtgcccagg agggtgggca gcttctacag ggtgcccagc     2160

cccaggcccg acaacagctt ccacgagaac aacgtgagca ccagggtgag cagcctgccc     2220

agcgagagca gcagcggcac caaccacagc aagaggcagc ccgccttcga cccctggaag     2280

agccccgaga acatcagcca cagcgagcag ctgaaggaga aggagaagca gggcttcttc     2340

aggagcatga agaagaagaa gaagaagagc cagaccgtgc ccaacagcga cagccccgac     2400

ctgctgaccc tgcagaagag catccacagc gccagcaccc ccagcagcag gcccaaggag     2460

tggaggcccg agaagatcag cgacctgcag acccagagcc agcccctgaa gagcctgagg     2520

aagctgctgc acctgagcag cgccagcaac caccccgcca gcagcgaccc caggttccag     2580

cccctgaccg cccagcagac caagaacagc ttcagcgaga tcaggatcca ccccctgagc     2640

caggccagcg gcggcagcag caacatcagg caggagcccg cccccaaggg caggcccgcc     2700

ctgcagctgc ccggccagat ggaccccggc tggcacgtga gcagcgtgac caggagcgcc     2760

accgagggcc ccagctacag cgagcagctg ggcgccaaga gcggccccaa cggccacccc     2820

tacaacagga ccaacaggag caggatgccc aacctgaacg acctgaagga gaccgccctg     2880

tga                                                                   2883


<210>  38
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5co-B

<400>  38
atgaaaattc ccaatatcgg taacgtgatg aataaattcg aaatacttgg agtggtaggt       60

gagggcgcct atggtgttgt acttaaatgt agacacaaag aaacacacga aatcgtggcg      120

atcaagaaat ttaaggattc cgaggagaat gaggaagtca aagagaccac actacgcgag      180

ttgaaaatgt tacgaactct aaaacaggaa aacattgtag agttaaagga ggcttttcgc      240

cgtcgcggta aactatacct ggtctttgag tatgttgaga aaaacatgct agaactgctc      300

gaggaaatgc ctaatggcgt cccgccagaa aaagtcaaat cgtatattta ccagcttata      360

aaggccatcc attggtgtca taaaaacgat atcgttcatc gcgacattaa gccagaaaat      420

ctattgatat cccacaacga cgtgctaaaa ctttgcgact tcggcttcgc taggaaccta      480

tccgaaggga ataacgcgaa ttataccgaa tatgttgcga cacgatggta ccgtagtcct      540

gaacttctat taggggcgcc ctacggtaaa tctgtagata tgtggtcagt cgggtgtata      600

ttaggagaac tttcagacgg tcaacctctg ttcccaggcg agtccgagat cgatcagctt      660

tttacaatac agaaggtatt aggtcccctc ccaagtgagc aaatgaagct attctattca      720

aatccccggt ttcatggcct tagatttccg gcggtgaacc accctcagag tctggagagg      780

cgttatctcg ggatacttaa ttcagtctta ctcgatctga tgaagaattt gctaaaactg      840

gaccctgctg atcggtacct tacagagcaa tgccttaatc acccgacttt tcaaactcaa      900

cgactgttgg accggagtcc gtcacgctca gctaaaagga aaccatacca cgtagaatca      960

tcgacattat cgaatcgaaa ccaagcgggt aagagtaccg ctttgcaaag ccatcatcga     1020

tccaatagta aagacattca gaatctgtca gtgggattgc ctagagctga cgaaggatta     1080

ccggcgaacg agagttttct gaacggcaac ctcgcaggcg catctctgtc tccgcttcat     1140

acgaaaactt accaagcgtc atcacagcca ggcagtacga gtaaagacct gactaacaat     1200

aatattccac atctgttatc accgaaggaa gctaagagca agaccgagtt cgacttcaac     1260

atagacccca aaccctccga gggtcctggc accaagtatc tcaaatcaaa ctctagatct     1320

cagcagaaca ggcacagctt catggagtcc tcacaaagta aagctgggac actgcagccc     1380

aacgaaaagc aaagccgaca ttcttatatt gacacgatcc ctcagagttc acgcagccct     1440

agctatcgga caaaagctaa gtcccacggt gccctttctg attcgaagag tgttagtaac     1500

ctttccgaag ctagagccca aattgcggag cctagtacat cgagatactt cccctccagc     1560

tgcctggacc ttaactctcc aaccagcccc actccaacgc gccactcaga taccaggaca     1620

ctgctctcac catccggaag aaataataga aatgaaggaa cgcttgactc tcggcgcact     1680

acgacaaggc acagcaagac gatggaagaa cttaagctac ctgagcacat ggacagttcg     1740

cattcccact cactctcggc gccacatgag tcgttttcct atggactggg ttacacaagt     1800

ccctttagct ctcagcagcg tcctcaccgc cactctatgt acgttacaag ggataaagtt     1860

cgcgctaagg ggttggatgg gagtctttcc attggccaag gcatggccgc gcgggcaaat     1920

tctctacaac ttctttcgcc acagccaggt gagcaactcc caccagaaat gaccgtcgcc     1980

agaagcagtg ttaaagaaac ttcgagggag gggacatcat cgtttcatac ccgccagaaa     2040

tctgagggcg gtgtatatca tgatcctcat tccgacgacg gaacggcccc caaagagaac     2100

cgacacctat acaatgaccc tgtcccaagg agagtgggat ctttctatcg agttccttca     2160

ccaagacctg ataacagttt ccatgagaac aacgtttcca cgagggtgtc aagtctacct     2220

tcggaatcat cttccggaac caatcactca aaacgccagc cagctttcga tccatggaaa     2280

tcaccggaaa acatcagtca tagcgagcaa ttgaaagaga aagaaaagca aggttttttc     2340

agaagtatga agaagaagaa aaagaagtca cagaccgtac ctaattcaga tagtccagac     2400

ttgttaacgc tccagaaatc aattcatagc gcatcgactc catcgtcccg accaaaggaa     2460

tggcgccctg agaagatctc cgatctgcag acccaatccc aacccctgaa gtctctcagg     2520

aaattactcc acctctcgtc tgctagtaac caccccgcat cgtctgaccc tcgcttccag     2580

ccgctgacag cccagcaaac aaagaacagt ttctcagaaa tccggattca tcctttaagc     2640

caagctagcg gcggtagttc taacataaga caagagcccg ctccaaaggg cagacccgct     2700

ctgcagttgc ctgggcagat ggatcccggg tggcacgtct catcagtaac ccgaagtgcc     2760

accgagggcc cgtcatattc agagcagctc ggagcgaaaa gtggtcctaa cgggcaccca     2820

tataatcgaa caaaccgttc aaggatgcca aatctcaacg atctaaagga aacggccctt     2880

taa                                                                   2883


<210>  39
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5co-C

<400>  39
atgaagatcc ccaatatcgg aaacgtgatg aacaaattcg agattctcgg agtggtgggc       60

gagggcgcct atggagtggt tttaaaatgc agacacaagg agacccacga gatcgtcgct      120

atcaaaaagt tcaaagactc cgaggaaaac gaagaggtca aggagaccac cttacgtgag      180

ctcaaaatgc tcagaacact gaagcaagag aatatcgtcg agctcaagga ggccttcaga      240

aggaggggca aactgtattt agtgttcgag tacgtggaga agaacatgct ggagctgctg      300

gaggaaatgc ccaacggcgt cccccccgaa aaggtgaaat cctacattta ccaactgatc      360

aaggccattc actggtgcca caaaaatgat atcgtccatc gtgacatcaa gcccgagaat      420

ctgctgatca gccataacga cgtgctgaaa ctgtgcgact tcggattcgc cagaaattta      480

agcgagggca acaacgccaa ttacaccgag tacgtcgcca caaggtggta taggagcccc      540

gagctgctgc tcggagcccc ttatggcaag agcgtggaca tgtggagcgt gggctgcatt      600

ctgggagaac tgtccgacgg ccagcctctg ttccccggcg agtccgagat tgaccagctg      660

ttcacaatcc agaaagtcct cggccctctg cccagcgaac aaatgaagct cttctacagc      720

aaccctcgtt tccacggttt aaggttcccc gccgtgaatc acccccagag cctcgagaga      780

aggtatctgg gcattctgaa cagcgtgctg ctcgatttaa tgaagaattt attaaagctg      840

gaccccgctg ataggtacct cacagagcag tgtttaaatc accccacctt ccagacccag      900

agactgctcg atcgtagccc tagcagatcc gccaaaagga agccttacca cgtcgagagc      960

tccactttaa gcaatcgtaa ccaagctgga aaatccaccg ctttacagtc ccaccatagg     1020

tccaacagca aagacattca gaatttaagc gtgggactgc ctagggctga cgagggcctc     1080

cccgccaacg aatccttttt aaatggcaat ctcgccggag ccagcctcag ccctttacat     1140

acaaaaacct accaagctag ctcccagccc ggtagcacct ccaaggacct caccaacaac     1200

aacatccccc atttactgtc ccccaaggag gccaagagca agaccgagtt tgactttaat     1260

atcgacccta agcccagcga gggacccggc acaaagtatc tgaagtccaa ttctcgtagc     1320

cagcagaatc gtcacagctt catggagagc tcccaaagca aggccggcac actgcagccc     1380

aatgagaagc aatctcgtca ttcctacatc gacaccatcc cccagagctc tcgtagcccc     1440

tcctatagga caaaggccaa gtcccacggc gctctgtccg attccaagtc cgtctccaat     1500

ttatccgagg ctcgtgccca gatcgccgaa cctagcacct ctcgttattt cccctcctct     1560

tgtctggacc tcaattcccc cacaagccct acacctactc gtcacagcga caccagaact     1620

ttactgagcc ccagcggaag gaataatcgt aacgagggca ctttagactc tcgtagaacc     1680

accacaaggc acagcaagac catggaggag ctgaagctgc ccgaacatat ggactcctcc     1740

cattcccatt ctttatccgc cccccacgag agcttcagct atggtttagg ctatacatcc     1800

cccttcagct cccagcagag accccacaga cactccatgt acgtgactcg tgataaggtg     1860

agggccaaag gactggatgg aagcctctcc atcggccaag gcatggccgc tcgtgccaat     1920

agcctccagt tattatcccc ccaacccgga gaacagctgc ctcccgaaat gacagtggcc     1980

agaagcagcg tcaaggaaac atctcgtgag ggaacctcca gctttcacac aaggcagaag     2040

agcgagggcg gagtctatca tgacccccac tccgatgacg gcacagcccc caaagagaat     2100

cgtcatctct acaacgaccc cgtgcctcgt agagtcggct ccttctacag agtccccagc     2160

cccagacccg acaacagctt tcacgagaac aacgtgagca ctcgtgtctc ctctttacct     2220

agcgagagct cctccggaac caaccacagc aaaaggcagc ccgccttcga cccttggaag     2280

tcccccgaaa acatcagcca cagcgagcag ctgaaggaga aagagaagca aggtttcttc     2340

agaagcatga aaaagaagaa gaaaaaatcc caaaccgtgc ccaactccga ctcccccgat     2400

ttactgaccc tccagaagtc catccactcc gcttccaccc ctagctccag acccaaggag     2460

tggaggcccg agaagatttc cgatttacag acacagagcc agcctctcaa gtctttaaga     2520

aagctgctgc atttatccag cgccagcaat caccccgctt ccagcgaccc taggttccag     2580

cctttaaccg cccagcagac caagaatagc ttttccgaga tccgtattca tcctctgagc     2640

caagctagcg gaggcagctc caacatcaga caagaacccg ctcctaaggg cagacccgct     2700

ttacaactcc ccggtcagat ggatcccggt tggcacgtga gcagcgtcac aaggagcgcc     2760

acagagggcc ccagctatag cgaacagctg ggcgccaaaa gcggacccaa cggccatccc     2820

tacaatagaa ccaatcgttc cagaatgccc aatctcaacg acctcaagga aacagcttta     2880

tga                                                                   2883


<210>  40
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5co-D

<400>  40
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtcgtcggc       60

gaaggcgctt atggcgttgt gctgaagtgc agacacaaag aaacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaagagaac gaggaagtga aagagacaac cctgcgcgag      180

ctgaagatgc tgcggaccct gaagcaagag aacatcgtgg aactgaaaga ggccttccgg      240

cggagaggca agctgtacct ggtgttcgag tacgtggaaa agaacatgct cgagctgctg      300

gaagagatgc ccaacggcgt gccacctgag aaagtgaagt cctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcacc gggacatcaa gcccgagaac      420

ctgctgatct cccacaacga cgtgctgaag ctgtgcgact tcggcttcgc cagaaatctg      480

agcgagggca acaacgccaa ctacaccgaa tacgtggcca ccagatggta cagaagccct      540

gagctgctgc tgggagcccc ttatggcaag tccgtggata tgtggagcgt gggctgtatc      600

ctgggagagc tgtctgatgg ccagcctctg tttcctggcg agtccgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccctctg cctagcgagc agatgaagct gttctacagc      720

aaccccagat tccacggcct gagattcccc gccgtgaatc accctcagag cctggaaaga      780

agatacctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaatct gctgaaactg      840

gaccccgccg acagatacct gaccgagcag tgcctgaacc atcctacctt tcagacccag      900

agactgctgg atcggagccc tagcagaagc gccaagagaa agccctacca cgtggaaagc      960

agcaccctga gcaacagaaa ccaggccggc aagtctacag ccctgcagag ccaccacaga     1020

agcaacagca aggacatcca gaacctgtcc gtgggcctgc ctagagccga tgaaggactg     1080

cctgccaacg agagcttcct gaacggaaat ctggctggcg cctctctgag ccctctgcac     1140

acaaagacat accaggccag cagccagcct ggcagcacaa gcaaggatct gaccaacaac     1200

aacatccctc atctgctgag ccccaaagag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcctagcga aggccctggc accaagtacc tgaagtccaa cagcagaagc     1320

cagcagaacc ggcactcctt catggaaagc tcccagagca aggccggcac actgcagcct     1380

aatgagaagc agagcagaca cagctacatc gacacaatcc cacagagcag caggtcccca     1440

agctacagga ccaaggccaa atctcacggc gccctgagcg atagcaagag cgtgtccaat     1500

ctgtccgagg ctagagccca gatcgccgag cctagcacca gcagatactt ccctagctcc     1560

tgcctggatc tgaacagccc aacaagcccc acacctacca ggcacagcga caccagaaca     1620

ctgctgtccc catccggcag aaacaaccgg aatgagggca ccctggacag cagacggacc     1680

accacaagac acagcaagac catggaagaa ctgaagctgc ccgagcacat ggactccagc     1740

cactctcatt ctctgagcgc ccctcacgag tccttctctt acggcctggg ctacacaagc     1800

cccttcagct ctcagcagag gccccacaga cactctatgt acgtgacccg ggacaaagtg     1860

cgcgccaaag gcctggatgg ctctctgtct atcggccaag gcatggccgc cagagccaat     1920

tctctgcagc tgctgtctcc tcagcctggg gaacaactgc ctcctgagat gaccgtggcc     1980

agatccagcg tgaaagaaac cagcagagag ggcacctcca gcttccacac cagacagaaa     2040

agcgaaggcg gagtgtacca cgatcctcac agcgacgacg gcacagcccc taaagagaac     2100

agacacctgt acaacgaccc cgtgcctaga agagtgggct ccttctacag agtgccttct     2160

cctagacctg acaactcctt ccacgagaac aatgtgtcca ccagagtgtc cagcctgcct     2220

tccgaaagca gctccggcac caaccactcc aagagacagc ctgctttcga cccctggaag     2280

tcccctgaga acatcagcca ctccgagcag ctgaaagaga aagagaagca gggctttttc     2340

cggtccatga agaagaagaa aaagaagtcc cagacggtcc ccaacagcga ctccccagat     2400

ctgctgaccc tgcagaagtc catccactcc gccagcacac ctagcagcag acccaaagag     2460

tggcggccag agaagatcag cgatctgcag acccagtctc agcctctgaa gtccctgagg     2520

aagctgctgc atctgagcag cgcctctaat caccctgcca gcagcgaccc tagatttcag     2580

ccactgacag cccagcagac caagaactcc ttcagcgaga tccggattca cccactgtct     2640

caggccagcg gcggcagcag caatatcaga caagagcccg ctcctaaggg cagacctgct     2700

ctgcaactgc ctggccagat ggatccagga tggcacgtgt cctctgtgac cagatccgcc     2760

acagagggac ctagctacag cgaacagctc ggcgccaagt ctggccctaa tggacacccc     2820

tacaaccgga ccaaccggtc cagaatgccc aacctgaacg acctcaaaga aacagccctg     2880

tga                                                                   2883


<210>  41
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coA1

<400>  41
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtcgtcggc       60

gaaggcgctt atggcgttgt gctgaagtgc agacacaaag aaacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaagagaac gaggaagtga aagagacaac cctgcgcgag      180

ctgaagatgc tgcggaccct gaagcaagag aacatcgtgg aactgaaaga ggccttccgg      240

cggagaggca agctgtacct ggtgttcgag tacgtggaaa agaacatgct cgagctgctg      300

gaagagatgc ccaacggcgt gccacctgag aaagtgaagt cctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcacc gggacatcaa gcccgagaac      420

ctgctgatct cccacaacga cgtgctgaag ctgtgcgact tcggcttcgc cagaaatctg      480

agcgagggca acaacgccaa ctacaccgaa tacgtggcca ccagatggta cagaagccct      540

gagctgctgc tgggagcccc ttacggcaag tccgtggata tgtggagcgt gggctgtatc      600

ctgggagagc tgtctgacgg ccagcctctg tttcctggcg agtccgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccctctg cctagcgagc agatgaagct gttctacagc      720

aaccccagat tccacggcct gagattcccc gccgtgaatc accctcagag cctggaaaga      780

agatacctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaatct gctgaaactg      840

gaccccgccg acagatacct gaccgagcag tgcctgaacc atcctacctt tcaaacccag      900

agactgctgg atcggagccc tagcagaagc gccaagagaa agccctacca cgtggaaagc      960

agcaccctga gcaacagaaa ccaggccggc aagtctacag ccctgcagag ccaccacaga     1020

agcaacagca aggacatcca gaacctgtcc gtgggcctgc ctagagccga cgaaggactg     1080

cctgccaacg agagcttcct gaacggaaat ctggctggcg cctctctgag ccctctgcac     1140

acaaagacat accaggccag cagccagcct ggcagcacaa gcaaggatct gaccaacaac     1200

aacatccctc atctgctgag ccccaaagag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcctagcga aggccctggc accaagtacc tgaagtccaa cagcagaagc     1320

cagcagaacc ggcactcctt catggaaagc tcccagagca aggccggcac actgcagcct     1380

aacgagaagc agagcagaca cagctacatc gacacaatcc cacagagcag caggtcccca     1440

agctacagga ccaaggccaa atctcacggc gccctgagcg atagcaagag cgtgtccaat     1500

ctgtccgagg ctagagccca gatcgccgag cctagcacca gcagatactt ccctagctcc     1560

tgcctggatc tgaacagccc aacaagcccc acacctacca ggcacagcga caccagaaca     1620

ctgctgtccc catccggcag aaacaaccgg aacgagggca ccctggacag cagacggacc     1680

accacaagac acagcaagac catggaagaa ctgaagctgc ccgagcacat ggactccagc     1740

cactctcatt ctctgagcgc ccctcacgag tccttctctt acggcctggg ctacacaagc     1800

cccttcagct ctcagcagag gccccacaga cacagcatgt atgtgacccg ggacaaagtg     1860

cgcgccaaag gcctggacgg ctctctgtct atcggccaag gcatggccgc cagagccaat     1920

tctctgcagc tgctgtctcc tcagcctggg gaacaactgc ctcctgagat gaccgtggcc     1980

agatccagcg tgaaagaaac cagcagagag ggcacctcca gcttccacac cagacagaaa     2040

agcgaaggcg gagtgtacca cgatcctcac agcgacgacg gcacagcccc taaagagaac     2100

agacacctgt acaacgaccc cgtgcctaga agagtgggct ccttctacag agtgccttct     2160

cctagacctg acaactcctt ccacgagaac aacgtgtcca ccagagtgtc cagcctgcct     2220

tccgaaagca gctccggcac caaccactcc aagagacagc ctgctttcga cccctggaag     2280

tcccctgaga acatcagcca ctccgagcag ctgaaagaga aagagaagca gggctttttc     2340

cggtccatga agaagaagaa aaagaagtcc cagacggtcc ccaacagcga ctccccagat     2400

ctgctgaccc tgcagaagtc catccactcc gccagcacac ctagcagcag acccaaagag     2460

tggcggccag agaagatcag cgatctgcag acccagtctc agcctctgaa gtccctgagg     2520

aagctgctgc atctgagcag cgcctctaat caccctgcca gcagcgaccc tagatttcag     2580

ccactgacag cccagcagac caagaactcc ttcagcgaga tccggattca cccactgtct     2640

caggccagcg gcggcagcag caatatcaga caagagcccg ctcctaaggg cagacctgct     2700

ctgcaactgc ctggccagat ggatccaggc tggcacgtgt cctctgtgac cagatccgcc     2760

acagagggac ctagctacag cgaacagctc ggcgccaagt ctggccctaa cggacacccc     2820

tacaaccgga ccaaccggtc cagaatgccc aacctgaacg acctcaaaga gactgccctt     2880

tga                                                                   2883


<210>  42
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coB1

<400>  42
atgaagatcc ctaatatcgg caacgtgatg aataagttcg agatcctggg agtggtggga       60

gagggagcat acggagtggt gctgaagtgc cgccacaagg agacccacga gatcgtggcc      120

atcaagaagt ttaaggatag cgaggagaat gaggaggtga aggagaccac actgagagag      180

ctgaagatgc tgaggacact gaagcaggag aacatcgtgg agctgaagga ggccttccgg      240

agaaggggca agctgtacct ggtgtttgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ccaatggcgt gccccctgag aaggtgaagt cctacatcta tcagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gagatatcaa gcctgagaac      420

ctgctgatct cccacaatga cgtgctgaag ctgtgcgatt tcggctttgc caggaacctg      480

agcgagggca acaacgccaa ttacacagag tacgtggcca cccgctggta cagaagccca      540

gagctgctgc tgggagcacc atacggcaag agcgtggaca tgtggtccgt gggctgcatc      600

ctgggcgagc tgtctgacgg ccagcctctg ttcccaggcg agagcgagat cgatcagctg      660

tttaccatcc agaaggtgct gggccctctg ccaagcgagc agatgaagct gttctactcc      720

aaccccagat tccacggcct gaggtttccc gccgtgaatc accctcagag cctggagcgc      780

cggtatctgg gcatcctgaa ctccgtgctg ctggatctga tgaagaatct gctgaagctg      840

gaccccgccg atcgctacct gaccgagcag tgtctgaatc accctacatt tcagacccag      900

cgcctgctgg accggagccc ttccagatct gccaagagga agccatatca cgtggagagc      960

tccaccctgt ccaatagaaa ccaggccggc aagtctacag ccctgcagag ccaccacagg     1020

agcaactcca aggacatcca gaatctgtcc gtgggactgc ctagggcaga cgagggactg     1080

ccagcaaacg agagcttcct gaacggaaac ctggcaggag catctctgag cccactgcac     1140

acaaagacct accaggcctc tagccagccc ggctccacat ctaaggacct gaccaacaat     1200

aacatcccac acctgctgtc tcccaaggag gccaagagca agaccgagtt cgactttaat     1260

atcgatccca agcctagcga gggccctggc acaaagtatc tgaagagcaa ctcccgctct     1320

cagcagaatc ggcactcctt catggagtcc tctcagtcta aggccggcac cctgcagcca     1380

aacgagaagc agagcaggca ctcctacatc gataccatcc cccagagctc cagaagccct     1440

tcctatagaa caaaggccaa gtctcacggc gccctgtctg acagcaagtc cgtgtctaat     1500

ctgagcgagg caagggcaca gatcgcagag cccagcacct cccggtactt tccttcttcc     1560

tgtctggacc tgaactctcc tacaagccca acacccaccc gccactccga tacacggacc     1620

ctgctgtctc caagcggcag aaataacagg aacgagggca ccctggattc tagaaggacc     1680

acaaccagac acagcaagac aatggaggag ctgaagctgc cagagcacat ggactcctct     1740

cactcccact ctctgagcgc ccctcacgag tccttctctt acggcctggg ctatacctcc     1800

cccttctcct cccaacaaag gccacaccgg cacagcatgt atgtgacaag ggacaaggtc     1860

cgggcaaagg gactggacgg aagcctgtcc atcggacagg gaatggcagc aagggccaac     1920

tccctgcagc tgctgtctcc tcagccagga gagcagctgc caccagagat gaccgtggca     1980

cgctctagcg tgaaggagac aagccgggag ggcacctcct ctttccacac acgccagaag     2040

tccgagggcg gcgtgtatca cgacccccac tctgacgacg gcacagcccc taaggagaac     2100

cggcacctgt acaacgatcc cgtgcctagg agggtgggat ccttctatag agtgccatct     2160

cccaggcctg acaatagctt tcacgagaat aacgtgtcca cccgcgtgag ctccctgcca     2220

tctgagtcta gctccggcac aaaccactct aagcggcagc ccgcctttga tccttggaag     2280

agcccagaga atatctctca cagcgagcag ctgaaggaga aggagaagca gggcttcttt     2340

agaagcatga agaagaagaa gaagaagagc cagaccgtgc ctaactccga ctctccagac     2400

ctgctgaccc tgcagaagtc catccacagc gcctccacac catctagcag gcctaaggag     2460

tggcggcctg agaagatcag cgatctgcag acccagagcc agccactgaa gtccctgagg     2520

aagctgctgc acctgtcctc tgccagcaac cacccagcca gctccgaccc aagattccag     2580

cccctgacag cccagcagac caagaacagc ttcagcgaga tcaggatcca cccactgtcc     2640

caggcatctg gaggatctag caacatcaga caggagccag caccaaaggg caggcccgcc     2700

ctgcagctgc ctggccagat ggacccaggc tggcacgtgt cctctgtgac acgctccgcc     2760

accgagggac catcctactc tgagcagctg ggagcaaaga gcggacctaa cggacaccca     2820

tataaccgga ccaatagatc caggatgccc aatctgaacg acctgaagga gacagccctg     2880

tga                                                                   2883


<210>  43
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coC1

<400>  43
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtggtgggc       60

gagggcgcct acggcgtggt gctgaagtgc aggcacaagg agacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaggagaac gaggaggtga aggagaccac cctgagggag      180

ctgaagatgc tgaggaccct gaagcaggag aacatcgtgg agctgaagga ggccttcagg      240

aggaggggca agctgtacct ggtgttcgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ccaacggcgt gccccccgag aaggtgaaga gctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gggacatcaa gcccgagaac      420

ctgctgatca gccacaacga cgtgctgaag ctgtgcgact tcggcttcgc caggaacctg      480

agcgagggca acaacgccaa ctacaccgag tacgtggcca ccaggtggta caggagcccc      540

gagctgctgc tgggcgcccc ctacggcaag agcgtggaca tgtggagcgt gggctgcatc      600

ctgggcgagc tgagcgacgg ccagcccctg ttccccggcg agagcgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccccctg cccagcgagc agatgaagct gttctacagc      720

aaccccaggt tccacggcct gaggttcccc gccgtgaacc acccccagag cctggagagg      780

aggtatctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaacct gctgaagctg      840

gaccccgccg acaggtatct gaccgagcag tgcctgaacc accccacctt ccagacccag      900

aggctgctgg acaggagccc cagcaggagc gccaagagga agccctacca cgtggagagc      960

agcaccctga gcaacaggaa ccaggccggc aagagcaccg ccctgcagag ccaccacagg     1020

agcaacagca aggacatcca gaacctgagc gtgggcctgc ccagggccga cgagggcctg     1080

cccgccaacg agagcttcct gaacggcaac ctggccggcg ccagcctgag ccccctgcac     1140

accaagacct accaggccag cagccagccc ggcagcacca gcaaggacct gaccaacaac     1200

aacatccccc acctgctgag ccccaaggag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcccagcga gggccccggc accaagtacc tgaagagcaa cagcaggagc     1320

cagcagaaca ggcacagctt catggagagc agccagagca aggccggcac cctgcagccc     1380

aacgagaagc agagcaggca cagctacatc gacaccatcc cccagagcag caggagcccc     1440

agctacagga ccaaggccaa gagccacggc gccctgagcg acagcaagag cgtgagcaac     1500

ctgagcgagg ccagggccca gatcgccgag cccagcacca gcagatactt ccccagcagc     1560

tgcctggacc tgaacagccc caccagcccc acccccaccc gccacagcga caccaggacc     1620

ctgctgagcc ccagcggcag gaacaacagg aacgagggca ccctggacag caggaggacc     1680

accaccaggc acagcaagac catggaggag ctgaagctgc ccgagcacat ggacagcagc     1740

cacagccaca gcctgagcgc cccccacgag agcttcagct acggcctggg ctacaccagc     1800

cccttcagca gccagcagag gccccacagg cacagcatgt acgtgaccag ggacaaagtg     1860

agggccaagg gcctggacgg cagcctgagc atcggccagg gcatggccgc cagggccaac     1920

agcctgcagc tgctgagccc ccagcccggc gagcagctgc cccccgagat gaccgtggcc     1980

aggagcagcg tgaaggagac cagcagggag ggcaccagca gcttccacac caggcagaag     2040

agcgagggcg gcgtgtacca cgacccccac agcgacgacg gcaccgcccc caaggagaac     2100

aggcacctgt acaacgaccc cgtgcccagg agggtgggca gcttctacag ggtgcccagc     2160

cccaggcccg acaacagctt ccacgagaac aatgtgagca ccagagtcag cagcctgccc     2220

agcgagagca gcagcggcac caaccacagc aagaggcagc ccgccttcga cccctggaag     2280

agccccgaga acatcagcca cagcgagcag ctgaaggaga aggagaagca gggcttcttc     2340

aggagcatga agaagaagaa gaagaagagc cagaccgtgc ccaacagcga cagccccgac     2400

ctgctgaccc tgcagaagag catccacagc gccagcaccc ccagcagcag gcccaaggag     2460

tggaggcccg agaagatcag cgacctgcag acccagagcc agcccctgaa gagcctgagg     2520

aagctgctgc acctgagcag cgccagcaac caccccgcca gcagcgaccc caggttccag     2580

cccctgaccg cccagcagac caagaacagc ttcagcgaga tcaggatcca ccccctgagc     2640

caggccagcg gcggcagcag caacatcagg caggagcccg cccccaaggg caggcccgcc     2700

ctgcagctgc ccggccagat ggaccccggc tggcacgtga gcagcgtgac caggagcgcc     2760

accgagggcc ccagctacag cgagcagctg ggcgccaaga gcggccccaa cggccacccc     2820

tacaacagga ccaacaggag caggatgccc aacctgaacg acctgaagga gaccgccctg     2880

tga                                                                   2883


<210>  44
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coD1

<400>  44
atgaagattc ccaacattgg gaatgtcatg aacaagtttg agattctggg cgtggtggga       60

gagggagcct acggcgttgt tctcaagtgc cgccacaagg aaactcacga gatcgtggct      120

atcaagaaat tcaaggatag tgaggaaaat gaagaagtca aggagacaac tcttcgagaa      180

ttaaagatgc tcagaacctt aaaacaagaa aatattgtgg aattgaaaga ggccttcaga      240

agacgaggaa aactctacct ggtgtttgaa tatgtggaga agaacatgct ggaactgttg      300

gaagagatgc ctaatggggt ccctcctgaa aaagtgaagt cctacatcta tcagctaatc      360

aaggccatcc actggtgcca caaaaatgat attgtccacc gggacatcaa accagagaat      420

ttgctcatca gccacaatga tgtgctcaaa ctttgtgatt ttggatttgc ccgaaacctc      480

tccgaaggca ataatgccaa ctacaccgag tacgtggcca cccgctggta tcgctctcca      540

gagcttctgc ttggggcccc ctatggcaag tctgtggaca tgtggagcgt tggctgcatc      600

ctgggcgagc tgtcagatgg gcagccactc ttcccagggg agtccgaaat cgaccagctg      660

ttcaccatcc agaaagtcct ggggccactt cccagcgagc aaatgaaact gttttacagc      720

aatccaagat ttcatggatt acgcttccct gctgtcaacc accctcaatc cctggagagg      780

agatacttgg gcatcctcaa cagtgtgctg ctggacctca tgaagaatct cctcaagttg      840

gaccctgccg acagatatct tactgagcag tgcctgaacc atcccacatt tcagacccag      900

agattgctag acaggagccc atcaaggagt gccaagagaa agccttatca tgtggagagc      960

agcacactat caaacagaaa ccaggctgga aagagtacag ctttacaatc tcaccaccgc     1020

tccaactcaa aggacattca gaacttgtca gttggactgc ccagagcaga tgagggactc     1080

cccgccaatg aaagcttcct gaatggaaac ctggcaggtg cctccctttc tcctctgcac     1140

acaaagacct accaggcgtc cagccaacct ggatccacat caaaagatct gaccaacaac     1200

aatatccccc accttttatc accaaaggaa gccaaaagta aaacagagtt cgacttcaac     1260

atcgacccca aaccttcaga agggcctggc accaaatatt taaaatcaaa ttcaagaagc     1320

cagcagaatc ggcactcatt catggaatcc tcacagagca aagctgggac actccagcca     1380

aatgagaagc agtccagaca tagttatatt gacaccattc ctcagtcatc cagatcccca     1440

agctaccgga caaaagccaa gagccatggc gcgctgtccg attccaagtc agtatcaaat     1500

ctttcagaag caagagctca gatcgcagag ccctccactt cccgctactt cccctcttca     1560

tgtttggatc tcaattcccc tacttcacct acacccaccc gtcatagtga cacacggacc     1620

ctgctcagtc caagcggcag gaataaccgg aacgagggca cactggacag ccgccgcacc     1680

accacaaggc attctaaaac catggaggag ctgaaattgc ccgagcacat ggactcttca     1740

cattctcatt cactatctgc acctcatgaa agttttagct atggattggg atataccagc     1800

cccttctcca gtcagcagag gcctcacaga cacagcatgt atgtcaccag ggacaaggtg     1860

cgggcaaagg gcctggatgg atctttaagt attggccagg gcatggctgc cagagcaaat     1920

tctcttcagc tgctttcacc ccagcctggg gaacaactgc caccagaaat gacagtggca     1980

aggagcagtg taaaagagac ctccagagaa ggaacatcca gcttccatac tcgccagaag     2040

tcggaaggtg gtgtgtacca cgacccacat tctgatgatg ggaccgctcc caaggaaaac     2100

aggcacctgt acaacgatcc tgtgccccgc cgcgtgggct ctttctacag agttccttct     2160

cctagaccag acaactcctt ccacgaaaac aatgtgtcca ccagagtgag cagtttaccc     2220

tctgagagtt ctagtggaac caatcattcc aaaagacagc ctgcatttga cccctggaag     2280

tccccggaga atatctccca ctccgagcag ctcaaagaaa aggagaaaca gggattcttc     2340

aggtccatga aaaagaagaa gaaaaaaagc cagacagtac caaacagcga ttctccagat     2400

cttctcactc tgcaaaaatc catccattct gccagtactc catcatctcg acccaaggag     2460

tggagacctg agaaaatttc agacctgcag actcagtctc agcccctgaa atctttgagg     2520

aagttattac acctctcatc agcttccaat cacccagcca gctcagatcc caggttccag     2580

ccgctcacag cccagcaaac aaaaaactct ttttcagaaa tacgtattca tcctttgtcc     2640

caggcatcag gaggcagcag caacatcagg caggagccag ctccaaaagg aaggcccgct     2700

ctgcagctgc caggacagat ggatccaggc tggcatgttt cctctgtcac tagatcagcc     2760

acagaaggac catcctattc tgaacagctg ggtgcaaaaa gtggccccaa tggccacccc     2820

tacaatagaa caaatcgcag cagaatgccc aacttaaatg acttgaaaga aacagcactg     2880

tga                                                                   2883


<210>  45
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coA2

<400>  45
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtcgtcggc       60

gaaggcgctt atggcgttgt gctgaagtgc agacacaaag aaacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaagagaac gaggaagtga aagagacaac cctgcgcgag      180

ctgaagatgc tgcggaccct gaagcaagag aacatcgtgg aactgaaaga ggccttccgg      240

cggagaggca agctgtacct ggtgttcgag tacgtggaaa agaacatgct cgagctgctg      300

gaagagatgc ccaacggcgt gccacctgag aaagtgaagt cctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcacc gggacatcaa gcccgagaac      420

ctgctgatct cccacaacga cgtgctgaag ctgtgcgact tcggcttcgc cagaaatctg      480

agcgagggca acaacgccaa ctacaccgaa tacgtggcca ccagatggta cagaagccct      540

gagctgctgc tgggagcccc ttacggcaag tccgtggata tgtggagcgt gggctgtatc      600

ctgggagagc tgtctgacgg ccagcctctg tttcctggcg agtccgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccctctg cctagcgagc agatgaagct gttctacagc      720

aaccccagat tccacggcct gagattcccc gccgtgaatc accctcagag cctggaaaga      780

agatacctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaatct gctgaaactg      840

gaccccgccg acagatacct gaccgagcag tgcctgaacc atcctacctt tcaaacccag      900

agactgctgg atcggagccc tagcagaagc gccaagagaa agccctacca cgtggaaagc      960

agcaccctga gcaacagaaa ccaggccggc aagtctacag ccctgcagag ccaccacaga     1020

agcaacagca aggacatcca gaacctgtcc gtgggcctgc ctagagccga cgaaggactg     1080

cctgccaacg agagcttcct gaacggaaat ctggctggcg cctctctgag ccctctgcac     1140

acaaagacat accaggccag cagccagcct ggcagcacaa gcaaggatct gaccaacaac     1200

aacatccctc atctgctgag ccccaaagag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcctagcga aggccctggc accaagtacc tgaagtccaa cagcagaagc     1320

cagcagaacc ggcactcctt catggaaagc tcccagagca aggccggcac actgcagcct     1380

aacgagaagc agagcagaca cagctacatc gacacaatcc cacagagcag caggtcccca     1440

agctacagga ccaaggccaa atctcacggc gccctgagcg atagcaagag cgtgtccaat     1500

ctgtccgagg ctagagccca gatcgccgag cctagcacca gcagatactt ccctagctcc     1560

tgcctggatc tgaacagccc aacaagcccc acacctacca ggcacagcga caccagaaca     1620

ctgctgtccc catccggcag aaacaaccgg aacgagggca ccctggacag cagacggacc     1680

accacaagac acagcaagac catggaagaa ctgaagctgc ccgagcacat ggactccagc     1740

cactctcatt ctctgagcgc ccctcacgag tccttctctt acggcctggg ctacacaagc     1800

cccttcagct ctcagcagag gccccacaga cacagtatgt atgtgacccg ggacaaagtg     1860

cgcgccaaag gcctggacgg ctctctgtct atcggccaag gcatggccgc cagagccaat     1920

tctctgcagc tgctgtctcc tcagcctggg gaacaactgc ctcctgagat gaccgtggcc     1980

agatccagcg tgaaagaaac cagcagagag ggcacctcca gcttccacac cagacagaaa     2040

agcgaaggcg gagtgtacca cgatcctcac agcgacgacg gcacagcccc taaagagaac     2100

agacacctgt acaacgaccc cgtgcctaga agagtgggct ccttctacag agtgccttct     2160

cctagacctg acaactcctt ccacgagaac aacgtgtcca ccagagtgtc cagcctgcct     2220

tccgaaagca gctccggcac caaccactcc aagagacagc ctgctttcga cccctggaag     2280

tcccctgaga acatcagcca ctccgagcag ctgaaagaga aagagaagca gggctttttc     2340

cggtccatga agaagaagaa aaagaagtcc cagacggtcc ccaacagcga ctccccagat     2400

ctgctgaccc tgcagaagtc catccactcc gccagcacac ctagcagcag acccaaagag     2460

tggcggccag agaagatcag cgatctgcag acccagtctc agcctctgaa gtccctgagg     2520

aagctgctgc atctgagcag cgcctctaat caccctgcca gcagcgaccc tagatttcag     2580

ccactgacag cccagcagac caagaactcc ttcagcgaga tccggattca cccactgtct     2640

caggccagcg gcggcagcag caatatcaga caagagcccg ctcctaaggg cagacctgct     2700

ctgcaactgc ctggccagat ggatccaggc tggcacgtgt cctctgtgac cagatccgcc     2760

acagagggac ctagctacag cgaacagctc ggcgccaagt ctggccctaa cggacacccc     2820

tacaaccgga ccaaccggtc cagaatgccc aatctgaacg acctcaaaga aacggccctg     2880

tga                                                                   2883


<210>  46
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coB2

<400>  46
atgaagatcc caaatatcgg caacgtgatg aataagttcg agatcctggg agtggtggga       60

gagggagcat atggcgtggt gctgaagtgc aggcacaagg agacccacga gatcgtggcc      120

atcaagaagt ttaaggacag cgaggagaat gaggaggtga aggagaccac actgagagag      180

ctgaagatgc tgaggacact gaagcaggag aacatcgtgg agctgaagga ggccttccgg      240

agaaggggca agctgtacct ggtgtttgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc caaatggcgt gccccctgag aaggtgaagt cctacatcta tcagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gagatatcaa gcccgagaac      420

ctgctgatct cccacaatga cgtgctgaag ctgtgcgatt tcggctttgc caggaacctg      480

agcgagggca acaacgccaa ttacacagag tacgtggcca ccaggtggta caggagccca      540

gagctgctgc tgggagcacc atacggcaag agcgtggata tgtggtccgt gggctgcatc      600

ctgggcgagc tgtctgacgg ccagcctctg ttcccaggcg agagcgagat cgatcagctg      660

tttaccatcc agaaggtgct gggccctctg ccaagcgagc agatgaagct gttctactcc      720

aaccctagat tccacggcct gaggtttccc gccgtgaatc accctcagag cctggagcgc      780

cggtatctgg gcatcctgaa ctccgtgctg ctggatctga tgaagaatct gctgaagctg      840

gaccccgccg atagatacct gaccgagcag tgtctgaatc accctacatt tcagacccag      900

cgcctgctgg accggagccc ttccagatct gccaagagga agccatatca cgtggagagc      960

tccaccctgt ccaatagaaa ccaggccggc aagtctacag ccctgcagag ccaccacagg     1020

agcaactcca aggacatcca gaatctgtcc gtgggactgc ctagggcaga cgagggactg     1080

ccagccaacg agagcttcct gaacggaaac ctggcaggag catctctgag cccactgcac     1140

acaaagacct accaggcctc tagccagccc ggctccacat ctaaggacct gaccaacaat     1200

aacatcccac acctgctgtc tcccaaggag gccaagagca agaccgagtt cgactttaat     1260

atcgatccaa agcctagcga gggaccaggc acaaagtatc tgaagagcaa ctcccgctct     1320

cagcagaatc ggcactcctt catggagtcc tctcagtcta aggccggcac cctgcagcct     1380

aacgagaagc agagcagaca ctcctacatc gataccatcc cccagagctc cagaagccct     1440

tcctatagaa caaaggccaa gtctcacggc gccctgtctg acagcaagtc cgtgtctaat     1500

ctgagcgagg caagggcaca gatcgcagag cccagcacct cccggtactt tccttcttcc     1560

tgtctggacc tgaactctcc tacaagccca acacccaccc gccacagcga tacacggacc     1620

ctgctgtctc caagcggccg caataaccgg aacgagggca ccctggattc tagaaggacc     1680

acaacccgcc acagcaagac aatggaggag ctgaagctgc cagagcacat ggactcctct     1740

cactcccact ctctgagcgc ccctcacgag tccttctctt acggcctggg ctatacctcc     1800

cccttctcct cccaacaaag accccacagg cacagcatgt acgtgacaag ggacaaggtc     1860

cgggcaaagg gactggacgg aagcctgtcc atcggacagg gaatggcagc aagggccaac     1920

tccctgcagc tgctgtctcc tcagccagga gagcagctgc caccagagat gaccgtggca     1980

cgctctagcg tgaaggagac aagccgggag ggcacctcct ctttccacac acgccagaag     2040

tccgagggag gcgtgtacca cgacccacac tctgacgacg gcacagcccc taaggagaac     2100

cggcacctgt acaacgatcc cgtgcctagg agggtgggat ccttctatag agtgccatct     2160

cccaggcctg acaatagctt tcacgagaat aacgtgtcca cccgcgtgag ctccctgcca     2220

tctgagtcta gctccggcac aaaccactct aagcggcagc ccgcctttga cccttggaag     2280

agcccagaga atatctctca cagcgagcag ctgaaggaga aggagaagca gggcttcttt     2340

cgcagcatga agaagaagaa gaagaagagc cagaccgtgc ctaactccga ctctccagac     2400

ctgctgaccc tgcagaagtc catccacagc gcctccacac catctagcag gcctaaggag     2460

tggcggcctg agaagatcag cgatctgcag acccagagcc agccactgaa gtccctgcgg     2520

aagctgctgc acctgtcctc tgcctccaac cacccagcaa gctccgaccc aagattccag     2580

cccctgacag cccagcagac caagaacagc ttcagcgaga tcaggatcca ccctctgtcc     2640

caagcatctg gaggatctag caacatcaga caggagccag caccaaaggg caggcccgcc     2700

ctgcagctgc ctggccagat ggatccaggc tggcacgtgt cctctgtgac acgcagcgcc     2760

accgagggac catcctactc tgagcagctg ggagcaaaga gcggacctaa cggacaccca     2820

tataaccgga ccaatagatc caggatgccc aatctgaacg acctgaagga gacagccctg     2880

tga                                                                   2883


<210>  47
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coC2

<400>  47
atgaagatcc ccaacatcgg caacgtgatg aacaagttcg agatcctggg cgtggtgggc       60

gagggcgcct acggcgtggt gctgaagtgc aggcacaagg agacccacga gatcgtggcc      120

atcaagaagt tcaaggacag cgaggagaac gaggaggtga aggagaccac cctgagggag      180

ctgaagatgc tgaggaccct gaagcaggag aacatcgtgg agctgaagga ggccttcagg      240

aggaggggca agctgtacct ggtgttcgag tacgtggaga agaacatgct ggagctgctg      300

gaggagatgc ccaacggcgt gccccctgag aaggtgaaga gctacatcta ccagctgatc      360

aaggccatcc actggtgcca caagaacgac atcgtgcaca gggacatcaa gcccgagaac      420

ctgctgatca gccacaacga cgtgctgaag ctgtgcgact tcggcttcgc caggaacctg      480

agcgagggca acaacgccaa ctacaccgag tacgtggcca ccaggtggta caggagcccc      540

gagctgctgc tgggcgcccc ctacggcaag agcgtggaca tgtggagcgt gggctgcatc      600

ctgggcgagc tgagcgacgg ccagcccctg ttccccggcg agagcgagat cgaccagctg      660

ttcaccatcc agaaggtgct gggccccctg cccagcgagc agatgaagct gttctacagc      720

aaccccaggt tccacggcct gaggttcccc gccgtgaacc acccccagag cctggagagg      780

agatacctgg gcatcctgaa cagcgtgctg ctggacctga tgaagaacct gctgaagctg      840

gaccccgccg acagatacct gaccgagcag tgcctgaacc accccacctt ccagacccag      900

aggctgctgg acaggagccc cagcaggagc gccaagagga agccctacca cgtggagagc      960

agcaccctga gcaacaggaa ccaggccggc aagagcaccg ccctgcagag ccaccacagg     1020

agcaacagca aggacatcca gaacctgagc gtgggcctgc ccagggccga cgagggcctg     1080

cccgccaacg agagcttcct gaacggcaac ctggccggcg ccagcctgag ccccctgcac     1140

accaagacct accaggccag cagccagccc ggcagcacca gcaaggacct gaccaacaac     1200

aacatccccc acctgctgag ccccaaggag gccaagagca agaccgagtt cgacttcaac     1260

atcgacccca agcccagcga gggccccggc accaagtacc tgaagagcaa cagcaggagc     1320

cagcagaaca ggcacagctt catggagagc agccagagca aggccggcac cctgcagccc     1380

aacgagaagc agagcaggca cagctacatc gacaccatcc cccagagcag caggagcccc     1440

agctacagga ccaaggccaa gagccacggc gccctgagcg acagcaagag cgtgagcaac     1500

ctgagcgagg ccagggccca gatcgccgag cccagcacca gcagatactt ccccagcagc     1560

tgcctggacc tgaacagccc caccagcccc acccccacca ggcacagcga caccaggacc     1620

ctgctgagcc ccagcggcag gaacaacagg aacgagggca ccctggacag caggaggacc     1680

accaccaggc acagcaagac catggaggag ctgaagctgc ccgagcacat ggacagcagc     1740

cacagccaca gcctgagcgc ccctcacgag agcttcagct acggcctggg ctacaccagc     1800

cccttcagca gccagcagag gccccacagg cacagcatgt acgtgaccag ggacaaagtg     1860

agggccaagg gcctggacgg cagcctgagc atcggccagg gcatggccgc cagggccaac     1920

agcctgcagc tgctgagccc ccagcccggc gagcagctgc ctcccgagat gaccgtggcc     1980

aggagcagcg tgaaggagac cagcagggag ggcaccagca gcttccacac caggcagaag     2040

agcgagggcg gcgtgtacca cgacccccac agcgacgacg gcaccgcccc caaggagaac     2100

aggcacctgt acaacgaccc cgtgcccagg agggtgggca gcttctacag ggtgcccagc     2160

cccaggcccg acaacagctt ccacgagaac aatgtgagca ccagagtgag cagcctgccc     2220

agcgagagca gcagcggcac caaccacagc aagaggcagc ccgccttcga cccctggaag     2280

agccccgaga acatcagcca cagcgagcag ctgaaggaga aggagaagca gggcttcttc     2340

aggagcatga agaagaagaa gaagaagagc cagaccgtgc ccaacagcga cagccccgac     2400

ctgctgaccc tgcagaagag catccacagc gccagcaccc ccagcagcag gcccaaggag     2460

tggaggcccg agaagatcag cgacctgcag acccagagcc agcccctgaa gagcctgagg     2520

aagctgctgc acctgagcag cgccagcaac caccccgcca gcagcgaccc caggttccag     2580

cccctgaccg cccagcagac caagaacagc ttcagcgaga tcaggatcca ccccctgagc     2640

caggccagcg gcggcagcag caacatcagg caggagcccg cccccaaggg caggcccgcc     2700

ctgcagctgc ccggccagat ggaccccggc tggcacgtga gcagcgtgac caggagcgcc     2760

accgagggcc ccagctacag cgagcagctg ggcgccaaga gcggccccaa cggccacccc     2820

tacaacagga ccaacaggag caggatgccc aacctgaacg acctgaagga gaccgccctg     2880

tga                                                                   2883


<210>  48
<211>  2883
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  engineered nucleic acid sequence CDKL5coD2

<400>  48
atgaagatcc ctaacatcgg gaatgtcatg aacaagtttg aaatcctggg ggtggtgggg       60

gagggagctt atggagttgt tttgaaatgt cgtcataagg aaactcatga aatcgtggcc      120

attaagaagt tcaaggacag tgaggagaat gaagaggtga aggagaccac tctccgcgag      180

ctgaagatgc tgaggacact gaagcaggaa aacattgtgg agctgaagga ggccttccga      240

cgacggggta agttgtacct ggtgtttgag tacgtggaga aaaacatgtt agaacttctg      300

gaggaaatgc caaacggtgt acctccagaa aaagtcaagt catatatcta ccagttgatc      360

aaagccatcc actggtgtca taaaaatgac atcgtccaca gagatataaa accagagaat      420

cttctgatct ctcacaatga tgtattaaaa ctttgtgatt ttggttttgc ccgtaatctg      480

tctgaaggta ataatgctaa ctatactgag tatgtagcaa ctcgctggta cagatcgcct      540

gaactgctac tgggtgctcc ttacggaaaa agtgtggaca tgtggagcgt tggttgtatc      600

ctaggagagc tgagtgatgg gcagccattg ttcccggggg agagtgaaat tgaccaacta      660

ttcacaatcc agaaagtgct ggggccacta ccaagtgaac aaatgaaact tttttattca      720

aatcctagat ttcacggtct acgtttcccc gctgtgaacc atcctcagtc cttagaacgg      780

cgatatttag gcattctgaa ctctgttctg ttagatctga tgaagaattt actaaaatta      840

gacccggctg accgctattt gacagagcag tgtttaaatc atccaacctt ccagacacag      900

agactcctag accgttcacc atctagaagt gcgaaaagaa aaccctacca cgttgaatca      960

agtaccctct ccaatcgcaa ccaggctggg aagagtactg ccctacaatc gcaccacagg     1020

agtaatagta aagatattca gaatctatct gtagggcttc ctcgagcgga cgagggtcta     1080

cctgccaatg aaagtttcct caatggtaac ttagctgggg catcactgtc gccccttcat     1140

actaagacct accaagcctc atctcaaccg gggagtacta gtaaagacct caccaacaat     1200

aacatccccc atttattatc tcccaaggag gcgaaatcca agactgagtt cgatttcaac     1260

attgacccaa agccctctga agggcctggc accaaatacc tgaaatctaa tagcagaagt     1320

caacaaaata ggcacagctt catggagtcc tcgcagagca aagctggcac actgcaacct     1380

aatgaaaagc aaagccgaca ttcatatatt gataccatcc cccaatctag tagaagccct     1440

tcataccgca cgaaagcaaa gtctcatggc gcactgtcag attctaaatc cgtcagcaat     1500

ctcagtgaag ccagggctca gatcgccgag ccctctacat ctcgctactt tccctcatcc     1560

tgcctggacc taaactcccc gacctctccc acccccacgc gtcacagcga cacccgaaca     1620

ttactttcac cttcgggcag gaataatcga aatgagggca ccctagattc gcgccgtacg     1680

actacacggc attcaaaaac catggaagaa ttgaaattgc ctgagcacat ggattcgtca     1740

cactctcaca gtctatcggc ccctcacgag agtttcagtt acgggcttgg ctacaccagt     1800

cccttctcca gccagcaacg cccacaccgc cactccatgt atgtcacccg cgacaaggtc     1860

cgtgccaaag gactcgatgg cagcctaagc ataggacagg gcatggccgc cagggccaac     1920

agtctccagt tactaagtcc ccagcccgga gaacagctgc cacccgagat gactgtggct     1980

agatcgtccg tgaaagagac aagtagggaa gggacctcta gcttccacac cagacagaaa     2040

tccgaggggg gcgtgtatca tgaccctcat agtgatgatg gtacagcccc gaaggaaaat     2100

agacacttgt acaatgaccc tgtgccccga agagttggct ccttctaccg ggtgccctct     2160

ccacggccag acaacagctt ccatgagaac aatgtttcaa cccgggtaag ctccctgcct     2220

agtgaaagtt catccggaac aaatcactcg aagcgtcagc cagccttcga cccctggaag     2280

tctccggaga acataagtca cagcgagcag ctcaaagaaa aagaaaaaca aggcttcttc     2340

agaagcatga agaagaaaaa aaaaaagtct caaacagtgc caaattccga ttcccccgac     2400

ttattaacac tacaaaagag catccattca gcttctacgc caagcagtag gcccaaagag     2460

tggagacccg agaagatttc tgatctacag acccagtctc agcctttaaa atcgctcagg     2520

aagctgctgc acctgtcttc cgcttcaaac cacccggcct ccagtgaccc tcggtttcag     2580

ccactgactg cccagcagac taaaaatagt ttttcagaga tcaggattca tcccttatca     2640

caggcctctg gcggcagcag caatatccgg caggagcctg cccctaaagg ccggcccgcg     2700

ttgcagctgc ccggccagat ggacccaggc tggcatgtgt catcagttac acgcagtgcc     2760

acagaaggcc ccagctactc agaacaattg ggtgctaagt caggacccaa tggccaccca     2820

tacaaccgaa ccaacagatc aaggatgccc aacctcaacg acctcaaaga aacagctctc     2880

tga                                                                   2883


