                         SEQUENCE LISTING

<110>  The Regents of the University of California
       Schaffer, David Vernon
       Lee, Hyuncheol
       Barnes, Christopher Ryan
 
<120>  COMPOSITIONS AND METHODS FOR PRODUCTION OF RECOMBINANT 
       ADENO-ASSOCIATED VIRUS

<130>  BERK-428WO

<150>  US 63/015,954
<151>  2020-04-27

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  497
<212>  PRT
<213>  Adeno-Associated Virus

<400>  1

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Gly Lys Thr Gly Ala Lys Lys Arg Asn Gly Thr 
            100                 105                 110         


Gly Asp Ser Ser Val Asp Gly Ala Thr Ala Ala Val Gly Thr Thr Met 
        115                 120                 125             


Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly Val 
    130                 135                 140                 


Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser 
            180                 185                 190         


Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn 
        195                 200                 205             


Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr Thr Asn 
    210                 215                 220                 


Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Val Ser Asp Ser 
225                 230                 235                 240 


Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Thr Ser Tyr Thr Val His Ser Ser Tyr Ala His 
        275                 280                 285             


Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Asn Ser Gly 
    290                 295                 300                 


Ser Ala Asn Lys Asp Ser Arg Gly Ser Ala Gly Met Ser Val Lys Asn 
305                 310                 315                 320 


Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Lys Thr Asp Asn Asn Asn 
                325                 330                 335     


Ser Asn Thr Trp Thr Gly Ala Ser Lys Tyr Asn Asn Gly Arg Ser Asn 
            340                 345                 350         


Gly Thr Ala Met Ala Ser His Lys Asp Asp Asp Lys Met Ser Gly Val 
        355                 360                 365             


Met Gly Lys Ser Ala Gly Ala Ser Asn Thr Ala Asp Asn Val Met Thr 
    370                 375                 380                 


Asp Lys Ala Thr Asn Val Ala Thr Arg Gly Thr Val Ala Val Asn Ser 
385                 390                 395                 400 


Ser Ser Thr Asp Ala Thr Gly Asp Val His Ala Met Gly Ala Gly Met 
                405                 410                 415     


Val Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp Gly His 
            420                 425                 430         


His Ser Met Gly Gly Gly Lys Asn Lys Asn Thr Val Ala Asn Ala Ser 
        435                 440                 445             


Ala Thr Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys Asn 
    450                 455                 460                 


Ser Lys Arg Trp Asn Val Tyr Thr Ser Asn Tyr Ala Lys Ser Ala Asn 
465                 470                 475                 480 


Val Asp Thr Val Asp Asn Asn Gly Tyr Thr Arg Gly Thr Arg Tyr Thr 
                485                 490                 495     


Arg 
    


<210>  2
<211>  499
<212>  PRT
<213>  Adeno-Associated Virus

<400>  2

Met Ala Ala Asp Gly Tyr Asp Trp Asp Thr Ser Gly Arg Trp Trp Lys 
1               5                   10                  15      


Lys Gly Lys Ala Arg His Lys Asp Asp Ser Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His Asp 
        35                  40                  45              


Lys Ala Tyr Asp Arg Asp Ser Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Lys Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Val Lys Thr Ala Gly Lys Lys Arg Val His Ser 
                85                  90                  95      


Val Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ala Asp Ser Val Asp Gly Ala Ala Ser Gly Gly Thr 
        115                 120                 125             


Asn Thr Met Ala Thr Gly Ser Gly Ala Met Ala Asp Asn Asn Gly Ala 
    130                 135                 140                 


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
145                 150                 155                 160 


Met Gly Asp Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn 
                165                 170                 175     


Asn His Tyr Lys Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Asn Asp Gly Thr Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp 
225                 230                 235                 240 


Ser Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr 
                245                 250                 255     


Gly Tyr Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr 
            260                 265                 270         


Ser Met Arg Thr Gly Asn Asn Thr Ser Tyr Thr Asp Val His Ser Ser 
        275                 280                 285             


Tyr Ala His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ser Arg Thr 
    290                 295                 300                 


Asn Thr Ser Gly Thr Thr Thr Ser Arg Ser Ala Gly Ala Ser Asp Arg 
305                 310                 315                 320 


Asp Ser Arg Asn Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Ser Ala 
                325                 330                 335     


Asp Asn Asn Asn Ser Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Asn 
            340                 345                 350         


Gly Arg Asp Ser Val Asn Gly Ala Met Ala Ser His Lys Asp Asp Lys 
        355                 360                 365             


Ser Gly Val Gly Lys Gly Ser Lys Thr Asn Val Asp Lys Val Met Thr 
    370                 375                 380                 


Asp Arg Thr Thr Asn Val Ala Thr Tyr Gly Ser Val Ser Thr Asn Arg 
385                 390                 395                 400 


Gly Asn Arg Ala Ala Thr Ala Asp Val Asn Thr Gly Val Gly Met Val 
                405                 410                 415     


Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp Gly His His 
            420                 425                 430         


Ser Met Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn Ser Thr Thr 
        435                 440                 445             


Ser Ala Ala Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys 
    450                 455                 460                 


Asn Ser Lys Arg Trp Asn Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn 
465                 470                 475                 480 


Val Asp Thr Val Asp Thr Asn Gly Val Tyr Ser Arg Gly Thr Arg Tyr 
                485                 490                 495     


Thr Arg Asn 
            


<210>  3
<211>  494
<212>  PRT
<213>  Adeno-Associated Virus

<400>  3

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Val Lys Ala Asn His Asp Asn Arg Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His 
        35                  40                  45              


Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Gly Val Ala Ala Lys Thr Ala Gly Lys Lys Gly Ala Val Asp Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Val Gly Lys Ser Gly Lys Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Thr Ser Gly Ser Asn 
        115                 120                 125             


Thr Met Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp 
    130                 135                 140                 


Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Trp Gly Asp 
145                 150                 155                 160 


Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr 
                165                 170                 175     


Lys Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser Thr 
            180                 185                 190         


Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn 
        195                 200                 205             


Asn Trp Gly Arg Lys Lys Ser Lys Asn Val Arg Gly Val Thr Asn Asp 
    210                 215                 220                 


Gly Thr Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp Ser Tyr 
225                 230                 235                 240 


Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Ser Tyr Thr Asp Val His Ser Ser Tyr Ala His 
        275                 280                 285             


Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Gly Thr Thr 
    290                 295                 300                 


Ser Gly Thr Thr Asn Ser Arg Ser Ala Gly Ser Met Ser Ala Arg Asn 
305                 310                 315                 320 


Trp Gly Cys Tyr Arg Arg Ser Lys Thr Ala Asn Asp Asn Asn Asn Ser 
                325                 330                 335     


Asn Trp Thr Ala Ala Ser Lys Tyr His Asn Gly Arg Asp Ser Val Asn 
            340                 345                 350         


Gly Ala Met Ala Ser His Lys Asp Asp Lys Met His Gly Asn Gly Lys 
        355                 360                 365             


Gly Thr Thr Ala Ser Asn Ala Asp Asn Val Met Thr Asp Arg Thr Thr 
    370                 375                 380                 


Asn Val Ala Thr Tyr Gly Thr Val Ala Asn Asn Ser Ser Asn Thr Ala 
385                 390                 395                 400 


Thr Thr Gly Thr Val Asn His Gly Ala Gly Met Val Trp Asp Arg Asp 
                405                 410                 415     


Val Tyr Gly Trp Ala Lys His Thr Asp Gly His His Ser Met Gly Gly 
            420                 425                 430         


Gly Lys His Met Lys Asn Thr Val Ala Asn Thr Thr Ser Ala Lys Ala 
        435                 440                 445             


Ser Thr Tyr Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp 
    450                 455                 460                 


Asn Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Thr Val Asp 
465                 470                 475                 480 


Thr Asn Gly Val Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490                 


<210>  4
<211>  492
<212>  PRT
<213>  Adeno-Associated Virus

<400>  4

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Val Lys Ala Asn His Asp Asn Arg Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Asp Ala Ala Ala His 
        35                  40                  45              


Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Gly Val Ala Ala Lys Thr Ala Gly Lys Lys Arg Val Asp Ser Asp 
                85                  90                  95      


Ser Ser Ser Gly Val Gly Lys Ser Gly Lys Ala Arg Lys Arg Asn Gly 
            100                 105                 110         


Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Thr Ser Gly Ser Asn Thr 
        115                 120                 125             


Met Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ser Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser Thr Trp 
            180                 185                 190         


Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn Asn 
        195                 200                 205             


Trp Gly Arg Lys Lys Ser Lys Asn Val Lys Val Thr Asn Asp Gly Thr 
    210                 215                 220                 


Thr Thr Ala Asn Asn Thr Ser Thr Val Val Thr Asp Ser Tyr Tyr Val 
225                 230                 235                 240 


Gly Ser Ala His Gly Cys Ala Asp Val Met Val Tyr Gly Tyr Thr Asn 
                245                 250                 255     


Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met Arg Thr 
            260                 265                 270         


Gly Asn Asn Ser Tyr Thr Asp Val His Ser Ser Tyr Ala His Ser Ser 
        275                 280                 285             


Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Gly Thr Thr Ser Gly 
    290                 295                 300                 


Thr Thr Asn Ser Arg Ser Ala Gly Ser Met Ser Ala Arg Asn Trp Gly 
305                 310                 315                 320 


Cys Tyr Arg Arg Ser Lys Thr Ala Asn Asp Asn Asn Asn Ser Asn Trp 
                325                 330                 335     


Thr Ala Ala Ser Lys Tyr His Asn Gly Arg Asp Ser Val Asn Gly Ala 
            340                 345                 350         


Met Ala Ser His Lys Asp Asp Lys Met His Gly Asn Gly Lys Gly Thr 
        355                 360                 365             


Thr Ala Ser Asn Ala Asp Asn Val Met Thr Asp Arg Thr Thr Asn Val 
    370                 375                 380                 


Ala Thr Tyr Gly Thr Val Ala Asn Asn Ser Ser Asn Thr Ala Thr Thr 
385                 390                 395                 400 


Arg Thr Val Asn Asp Gly Ala Gly Met Val Trp Asp Arg Asp Val Tyr 
                405                 410                 415     


Gly Trp Ala Lys His Thr Asp Gly His His Ser Met Gly Gly Gly Lys 
            420                 425                 430         


His Met Lys Asn Thr Val Ala Asn Thr Thr Ser Ala Lys Ala Ser Thr 
        435                 440                 445             


Tyr Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr 
    450                 455                 460                 


Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Thr Val Asp Thr Asn 
465                 470                 475                 480 


Gly Val Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490         


<210>  5
<211>  724
<212>  PRT
<213>  Adeno-Associated Virus

<400>  5

Met Ser Phe Val Asp His Pro Pro Asp Trp Leu Glu Glu Val Gly Glu 
1               5                   10                  15      


Gly Leu Arg Glu Phe Leu Gly Leu Glu Ala Gly Pro Pro Lys Pro Lys 
            20                  25                  30          


Pro Asn Gln Gln His Gln Asp Gln Ala Arg Gly Leu Val Leu Pro Gly 
        35                  40                  45              


Tyr Asn Tyr Leu Gly Pro Gly Asn Gly Leu Asp Arg Gly Glu Pro Val 
    50                  55                  60                  


Asn Arg Ala Asp Glu Val Ala Arg Glu His Asp Ile Ser Tyr Asn Glu 
65                  70                  75                  80  


Gln Leu Glu Ala Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala Asp 
                85                  90                  95      


Ala Glu Phe Gln Glu Lys Leu Ala Asp Asp Thr Ser Phe Gly Gly Asn 
            100                 105                 110         


Leu Gly Lys Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro Phe 
        115                 120                 125             


Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Thr Gly Lys Arg Ile 
    130                 135                 140                 


Asp Asp His Phe Pro Lys Arg Lys Lys Ala Arg Thr Glu Glu Asp Ser 
145                 150                 155                 160 


Lys Pro Ser Thr Ser Ser Asp Ala Glu Ala Gly Pro Ser Gly Ser Gln 
                165                 170                 175     


Gln Leu Gln Ile Pro Ala Gln Pro Ala Ser Ser Leu Gly Ala Asp Thr 
            180                 185                 190         


Met Ser Ala Gly Gly Gly Gly Pro Leu Gly Asp Asn Asn Gln Gly Ala 
        195                 200                 205             


Asp Gly Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp 
    210                 215                 220                 


Met Gly Asp Arg Val Val Thr Lys Ser Thr Arg Thr Trp Val Leu Pro 
225                 230                 235                 240 


Ser Tyr Asn Asn His Gln Tyr Arg Glu Ile Lys Ser Gly Ser Val Asp 
                245                 250                 255     


Gly Ser Asn Ala Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
            260                 265                 270         


Phe Asp Phe Asn Arg Phe His Ser His Trp Ser Pro Arg Asp Trp Gln 
        275                 280                 285             


Arg Leu Ile Asn Asn Tyr Trp Gly Phe Arg Pro Arg Ser Leu Arg Val 
    290                 295                 300                 


Lys Ile Phe Asn Ile Gln Val Lys Glu Val Thr Val Gln Asp Ser Thr 
305                 310                 315                 320 


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
                325                 330                 335     


Asp Asp Tyr Gln Leu Pro Tyr Val Val Gly Asn Gly Thr Glu Gly Cys 
            340                 345                 350         


Leu Pro Ala Phe Pro Pro Gln Val Phe Thr Leu Pro Gln Tyr Gly Tyr 
        355                 360                 365             


Ala Thr Leu Asn Arg Asp Asn Thr Glu Asn Pro Thr Glu Arg Ser Ser 
    370                 375                 380                 


Phe Phe Cys Leu Glu Tyr Phe Pro Ser Lys Met Leu Arg Thr Gly Asn 
385                 390                 395                 400 


Asn Phe Glu Phe Thr Tyr Asn Phe Glu Glu Val Pro Phe His Ser Ser 
                405                 410                 415     


Phe Ala Pro Ser Gln Asn Leu Phe Lys Leu Ala Asn Pro Leu Val Asp 
            420                 425                 430         


Gln Tyr Leu Tyr Arg Phe Val Ser Thr Asn Asn Thr Gly Gly Val Gln 
        435                 440                 445             


Phe Asn Lys Asn Leu Ala Gly Arg Tyr Ala Asn Thr Tyr Lys Asn Trp 
    450                 455                 460                 


Phe Pro Gly Pro Met Gly Arg Thr Gln Gly Trp Asn Leu Gly Ser Gly 
465                 470                 475                 480 


Val Asn Arg Ala Ser Val Ser Ala Phe Ala Thr Thr Asn Arg Met Glu 
                485                 490                 495     


Leu Glu Gly Ala Ser Tyr Gln Val Pro Pro Gln Pro Asn Gly Met Thr 
            500                 505                 510         


Asn Asn Leu Gln Gly Ser Asn Thr Tyr Ala Leu Glu Asn Thr Met Ile 
        515                 520                 525             


Phe Asn Ser Gln Pro Ala Asn Pro Gly Thr Thr Ala Thr Tyr Leu Glu 
    530                 535                 540                 


Gly Asn Met Leu Ile Thr Ser Glu Ser Glu Thr Gln Pro Val Asn Arg 
545                 550                 555                 560 


Val Ala Tyr Asn Val Gly Gly Gln Met Ala Thr Asn Asn Gln Ser Ser 
                565                 570                 575     


Thr Thr Ala Pro Ala Thr Gly Thr Tyr Asn Leu Gln Glu Ile Val Pro 
            580                 585                 590         


Gly Ser Val Trp Met Glu Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
        595                 600                 605             


Ala Lys Ile Pro Glu Thr Gly Ala His Phe His Pro Ser Pro Ala Met 
    610                 615                 620                 


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Met Met Leu Ile Lys Asn 
625                 630                 635                 640 


Thr Pro Val Pro Gly Asn Ile Thr Ser Phe Ser Asp Val Pro Val Ser 
                645                 650                 655     


Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Thr Val Glu Met Glu 
            660                 665                 670         


Trp Glu Leu Lys Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln 
        675                 680                 685             


Tyr Thr Asn Asn Tyr Asn Asp Pro Gln Phe Val Asp Phe Ala Pro Asp 
    690                 695                 700                 


Ser Thr Gly Glu Tyr Arg Thr Thr Arg Pro Ile Gly Thr Arg Tyr Leu 
705                 710                 715                 720 


Thr Arg Pro Leu 
                


<210>  6
<211>  496
<212>  PRT
<213>  Adeno-Associated Virus

<400>  6

Met Thr Asp Gly Tyr Asp Trp Asp Asn Ser Gly Val Arg Trp Trp Ala 
1               5                   10                  15      


Gly Ala Lys Lys Ala Asn His Asp Asn Ala Arg Gly Val Gly Tyr Lys 
            20                  25                  30          


Tyr Gly Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Lys Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Gly Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala 
65                  70                  75                  80  


Lys Lys Arg Val Gly Val Ala Gly Thr Ala Gly Lys Lys Arg Ser Asp 
                85                  90                  95      


Ser Ser Thr Gly Gly Lys Lys Gly Lys Ala Lys Lys Lys Val Asp Thr 
            100                 105                 110         


Gly Ala Gly Asp Gly Gly Ser Thr Ser Gly Ala Met Ser Asp Asp Ser 
        115                 120                 125             


Met Arg Ala Ala Ala Gly Gly Ala Ala Val Gly Gly Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Asn Ala Ser Gly Asp Trp His Cys Asp Ser Thr Trp Ser Gly 
145                 150                 155                 160 


His Val Thr Thr Thr Ser Thr Arg Thr Trp Val Thr Tyr Asn Asn His 
                165                 170                 175     


Tyr Lys Arg Gly Ser Ser Asn Thr Tyr Asn Gly Ser Thr Trp Gly Tyr 
            180                 185                 190         


Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn Asn Asn Trp Gly 
        195                 200                 205             


Met Arg Lys Ala Met Arg Val Lys Asn Val Lys Val Thr Thr Ser Asn 
    210                 215                 220                 


Gly Thr Thr Val Ala Asn Asn Thr Ser Thr Val Ala Asp Ser Ser Tyr 
225                 230                 235                 240 


Tyr Val Met Asp Ala Gly Gly Ser Asn Asp Val Met Val Tyr Gly Tyr 
                245                 250                 255     


Cys Gly Val Thr Gly Asn Thr Ser Thr Asp Arg Asn Ala Tyr Cys Tyr 
            260                 265                 270         


Ser Met Arg Thr Gly Asn Asn Thr Tyr Ser Lys Val His Ser Met Tyr 
        275                 280                 285             


Ala His Ser Ser Asp Arg Met Asn Asp Tyr Trp Gly Ser Thr Thr Thr 
    290                 295                 300                 


Gly Thr Thr Asn Ala Gly Thr Ala Thr Thr Asn Thr Lys Arg Thr Asn 
305                 310                 315                 320 


Ser Asn Lys Lys Asn Trp Gly Ser Lys Gly Ser Lys Thr Ala Asn Asn 
                325                 330                 335     


Tyr Lys Ala Thr Gly Ser Asp Ser Lys Tyr Thr His Ser Thr Asp Gly 
            340                 345                 350         


Arg Trp Ser Ala Thr Gly Met Ala Thr Ala Gly Ala Asp Ser Lys Ser 
        355                 360                 365             


Asn Ser Ala Gly Lys Asn Gly Asn Thr Ala Thr Val Gly Thr Thr Ser 
    370                 375                 380                 


Ala Ala Thr Asn Ala Thr Asp Thr Asp Met Trp Gly Asn Gly Gly Asp 
385                 390                 395                 400 


Ser Asn Ser Asn Thr Val Asp Arg Thr Ala Gly Ala Val Gly Met Val 
                405                 410                 415     


Trp Asn Arg Asp Tyr Tyr Gly Trp Ala Lys His Thr Asp Gly His His 
            420                 425                 430         


Ser Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn Ala Thr Thr Ser 
        435                 440                 445             


Ser Thr Val Asn Ser Thr Tyr Ser Thr Gly Val Ser Val Asp Trp Lys 
    450                 455                 460                 


Arg Ser Lys Arg Trp Asn Val Thr Ser Asn Tyr Gly Asn Ser Trp Ala 
465                 470                 475                 480 


Asp Ala Ala Gly Lys Tyr Thr Arg Ala Gly Thr Arg Tyr Thr His His 
                485                 490                 495     


<210>  7
<211>  499
<212>  PRT
<213>  Adeno-Associated Virus

<400>  7

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser 
                85                  90                  95      


Asp Ser Ser Ser Gly Gly Lys Thr Gly Ala Lys Lys Arg Asn Gly Thr 
            100                 105                 110         


Gly Asp Ser Ser Val Asp Gly Ala Thr Ala Ala Val Gly Thr Thr Met 
        115                 120                 125             


Ala Ser Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly Val 
    130                 135                 140                 


Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp Arg 
145                 150                 155                 160 


Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr Lys 
                165                 170                 175     


Ser Ser Ala Ser Thr Gly Ala Ser Asn Asp Asn His Tyr Gly Tyr Ser 
            180                 185                 190         


Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp Arg Asn 
        195                 200                 205             


Asn Asn Trp Gly Arg Lys Arg Asn Lys Asn Val Lys Val Thr Thr Asn 
    210                 215                 220                 


Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Val Ser Asp Ser 
225                 230                 235                 240 


Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr 
                245                 250                 255     


Thr Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met 
            260                 265                 270         


Arg Thr Gly Asn Asn Thr Ser Tyr Thr Asp Val His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Asn Arg Thr Asn Ser 
    290                 295                 300                 


Gly Ser Ala Asn Lys Asp Ser Arg Gly Ser Ala Gly Met Ser Val Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Tyr Arg Arg Val Ser Lys Thr Lys Thr Asp Asn Asn 
                325                 330                 335     


Asn Ser Asn Thr Trp Thr Gly Ala Ser Lys Tyr Asn Asn Gly Arg Ser 
            340                 345                 350         


Asn Gly Thr Ala Met Ala Ser His Lys Asp Asp Lys Asp Lys Met Ser 
        355                 360                 365             


Gly Val Met Gly Lys Ser Ala Gly Ala Ser Asn Thr Ala Asp Asn Val 
    370                 375                 380                 


Met Thr Asp Lys Ala Thr Asn Val Ala Thr Arg Gly Thr Val Ala Val 
385                 390                 395                 400 


Asn Ser Ser Ser Thr Asp Ala Thr Gly Asp Val His Val Met Gly Ala 
                405                 410                 415     


Gly Met Val Trp Asp Arg Asp Val Tyr Gly Trp Ala Lys His Thr Asp 
            420                 425                 430         


Gly His His Ser Met Gly Gly Gly Lys His Lys Asn Thr Val Ala Asn 
        435                 440                 445             


Ala Ser Ala Thr Lys Ala Ser Thr Tyr Ser Thr Gly Val Ser Val Trp 
    450                 455                 460                 


Lys Asn Ser Lys Arg Trp Asn Val Tyr Thr Ser Asn Tyr Ala Lys Ser 
465                 470                 475                 480 


Ala Asn Val Asp Thr Val Asp Asn Asn Gly Tyr Thr Arg Gly Thr Arg 
                485                 490                 495     


Tyr Thr Arg 
            


<210>  8
<211>  487
<212>  PRT
<213>  Adeno-Associated Virus

<400>  8

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Asp 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asn Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Lys Ala Gly Asp Asn Tyr Arg Tyr Asn His 
    50                  55                  60                  


Ala Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys 
65                  70                  75                  80  


Lys Arg Val Gly Val Gly Ala Lys Thr Ala Ala Lys Lys Arg Val Ser 
                85                  90                  95      


Arg Ser Asp Ser Ser Thr Gly Gly Lys Lys Gly Ala Arg Lys Arg Asn 
            100                 105                 110         


Gly Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Ser Ser Val Gly Ser 
        115                 120                 125             


Gly Thr Val Ala Ala Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala 
    130                 135                 140                 


Asp Gly Val Gly Asn Ala Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
145                 150                 155                 160 


Gly Asp Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn 
                165                 170                 175     


His Tyr Lys Ser Ser Thr Ala Gly Ser Thr Asn Asp Asn Thr Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Lys Arg Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Thr Asn Asp Gly Val Thr Thr Ala Asn Asn Thr Ser Thr Val Ser Asp 
225                 230                 235                 240 


Ser Tyr Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly 
                245                 250                 255     


Tyr Thr Asn Asn Gly Ser Ser Val Gly Arg Ser Ser Tyr Cys Tyr Ser 
            260                 265                 270         


Met Arg Thr Gly Asn Asn Ser Tyr Ser Asp Val His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ala Arg Thr Ser Asn 
    290                 295                 300                 


Gly Gly Thr Ala Gly Asn Arg Tyr Gly Gly Ser Thr Met Ala Ala Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Arg Arg Val Ser Lys Thr Asp Asn Asn Asn Ser Asn 
                325                 330                 335     


Ala Trp Thr Gly Ala Thr Lys Tyr His Asn Gly Arg Asn Ser Val Asn 
            340                 345                 350         


Gly Val Ala Met Ala Thr His Lys Asp Asp Asp Arg Ser Ser Gly Val 
        355                 360                 365             


Gly Lys Thr Gly Ala Thr Asn Lys Thr Thr Asn Val Met Thr Asn Arg 
    370                 375                 380                 


Thr Asn Val Ala Thr Tyr Gly Val Ser Ser Asn Ala Ala Asn Thr Ala 
385                 390                 395                 400 


Ala Thr Val Val Asn Asn Gly Ala Gly Met Val Trp Asn Arg Asp Val 
                405                 410                 415     


Tyr Gly Trp Ala Lys His Thr Asp Gly Asn His Ser Met Gly Gly Gly 
            420                 425                 430         


Lys His Lys Asn Thr Val Ala Asn Val Thr Ala Lys Ala Ser Thr Tyr 
        435                 440                 445             


Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr Thr 
    450                 455                 460                 


Ser Asn Lys Thr Gly Val Asp Ala Val Asp Ser Gly Val Tyr Ser Arg 
465                 470                 475                 480 


Gly Thr Arg Tyr Thr Arg Asn 
                485         


<210>  9
<211>  490
<212>  PRT
<213>  Adeno-Associated Virus

<400>  9

Met Ala Ala Asp Gly Tyr Asp Trp Asp Asn Ser Gly Arg Trp Trp Ala 
1               5                   10                  15      


Lys Gly Ala Lys Lys Ala Asn Lys Asp Asp Gly Arg Gly Val Gly Tyr 
            20                  25                  30          


Lys Tyr Gly Asn Gly Asp Lys Gly Val Asn Ala Ala Asp Ala Ala Ala 
        35                  40                  45              


His Asp Lys Ala Tyr Asp Ala Gly Asp Asn Tyr Arg Tyr Asn His Ala 
    50                  55                  60                  


Asp Ala Arg Asp Thr Ser Gly Gly Asn Gly Arg Ala Val Ala Lys Lys 
65                  70                  75                  80  


Arg Val Gly Val Gly Ala Lys Thr Ala Gly Lys Lys Arg Val Ser Arg 
                85                  90                  95      


Ser Asp Ser Ser Thr Gly Gly Lys Lys Gly Ala Arg Lys Arg Asn Gly 
            100                 105                 110         


Thr Gly Asp Ser Ser Val Asp Gly Ala Ala Ser Gly Val Gly Asn Thr 
        115                 120                 125             


Met Ala Ala Gly Gly Gly Ala Met Ala Asp Asn Asn Gly Ala Asp Gly 
    130                 135                 140                 


Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Gly Asp 
145                 150                 155                 160 


Arg Val Thr Thr Ser Thr Arg Thr Trp Ala Thr Tyr Asn Asn His Tyr 
                165                 170                 175     


Lys Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp Asn Thr Tyr Gly 
            180                 185                 190         


Tyr Ser Thr Trp Gly Tyr Asp Asn Arg His Cys His Ser Arg Asp Trp 
        195                 200                 205             


Arg Asn Asn Asn Trp Gly Arg Lys Arg Ser Lys Asn Val Lys Val Thr 
    210                 215                 220                 


Asn Gly Thr Lys Thr Ala Asn Asn Thr Ser Thr Val Thr Asp Ser Tyr 
225                 230                 235                 240 


Tyr Val Gly Ser Ala His Gly Cys Ala Asp Val Met Tyr Gly Tyr Thr 
                245                 250                 255     


Asn Asn Gly Ser Ala Val Gly Arg Ser Ser Tyr Cys Tyr Ser Met Arg 
            260                 265                 270         


Thr Gly Asn Asn Thr Tyr Thr Asp Val His Ser Ser Tyr Ala His Ser 
        275                 280                 285             


Ser Asp Arg Met Asn Asp Tyr Tyr Tyr Ser Arg Thr Thr Thr Gly Gly 
    290                 295                 300                 


Thr Ala Asn Thr Thr Gly Ser Gly Gly Asn Thr Met Ala Asn Ala Lys 
305                 310                 315                 320 


Asn Trp Gly Cys Tyr Arg Arg Val Ser Thr Thr Thr Gly Asn Asn Asn 
                325                 330                 335     


Ser Asn Ala Trp Thr Ala Gly Thr Lys Tyr His Asn Gly Arg Asn Ser 
            340                 345                 350         


Ala Asn Gly Ala Met Ala Thr His Lys Asp Asp Arg Ser Asn Gly Gly 
        355                 360                 365             


Lys Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val Met Thr Ser 
    370                 375                 380                 


Lys Thr Thr Asn Val Ala Thr Tyr Gly Val Ala Asp Asn Asn Thr Ala 
385                 390                 395                 400 


Gly Thr Val Asn Ser Gly Ala Gly Met Val Trp Asn Arg Asp Val Tyr 
                405                 410                 415     


Gly Trp Ala Lys His Thr Asp Gly Asn His Ser Met Gly Gly Gly Lys 
            420                 425                 430         


His Lys Asn Thr Val Ala Asp Thr Thr Asn Ser Lys Asn Ser Thr Tyr 
        435                 440                 445             


Ser Thr Gly Val Ser Val Trp Lys Asn Ser Lys Arg Trp Asn Tyr Thr 
    450                 455                 460                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Ala Val Asn Thr Gly Val 
465                 470                 475                 480 


Tyr Ser Arg Gly Thr Arg Tyr Thr Arg Asn 
                485                 490 


