                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Incorporated
 
<120>  Circular Bifunctional Aptamers and Trifunctional Aptamers 
       Targeting Tau

<130>  10457-451PC0

<140>  pct/us21/20322
<141>  2021-03-01

<150>  62/983,173
<151>  2020-02-28

<160>  57    

<170>  PatentIn version 3.5

<210>  1
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  1
cgtaaatcag tcagaaggcg tggtaccacg ctttc                                  35


<210>  2
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  2
tgactgattt acggaagctg aataaggact gcttaggatt gcgatgattc agcttc           56


<210>  3
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  3
cgtaaatcag tcagaagtcg acgccggtcg acttc                                  35


<210>  4
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  4
tgactgattt acggaagtta cggacggatg tcagtggtat agtaatccgt aacttc           56


<210>  5
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  5
tgactgattt acggaagctg aataaggact gcttaggatt gcgatgattc agcttc           56


<210>  6
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  6
cgtaaatcag tcagaagctg aataaggact gcttaggatt gcgatgattc agcttc           56


<210>  7
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  7
cgtaaatcag tcagaaggcg tggtaccacg ctttctgact gatttacgga agctgaataa       60

ggactgctta ggattgcgat gattcagctt c                                      91


<210>  8
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  8
tttttttttt tttgaaggcg tggtaccacg ctttcttttt ttttttttga agctgaataa       60

ggactgctta ggattgcgat gattcagctt c                                      91


<210>  9
<211>  14
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  9
gcgtggtacc acgc                                                         14


<210>  10
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  10
cagcaccgtc aactgaataa ggactgctta ggattgcgat gattcagggt gatgcgattg       60

agatgt                                                                  66


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  11
ctgaataagg actgcttagg attgcgatga ttcag                                  35


<210>  12
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  12
cgtaaatcag tcagaaggcg tggtaccacg ctttc                                  35


<210>  13
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  13
tgactgattt acggaagctg aataaggact gcttaggatt gcgatgattc agcttc           56


<210>  14
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  14
cgtaaatcag tcagaagctg aataaggact gcttaggatt gcgatgattc agcttc           56


<210>  15
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  15
tttttttttt tttgaagctg aataaggact gcttaggatt gcgatgattc agcttctttt       60

tttttttttg aaggcgtggt accacgcttt c                                      91


<210>  16
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tau peptide

<400>  16

Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg 
1               5                   10                  


<210>  17
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tau peptide

<400>  17

Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
1               5                   10              


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  tau peptide

<400>  18

Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser 
1               5                   10              


<210>  19
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  19
aggatagggg gtagctcggt cgtgtttttg ggttgtttgg tgggtcttct g                51


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  20
tcacctgaga cttgacgatg g                                                 21


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  21
tggacagacg atagcact                                                     18


<210>  22
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer


<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  22
tcacctgaga cttgacgatg gngagtgcta tcgtctgtcc a                           41


<210>  23
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  23
tgactgattt acggaagctg aataaggact gcttaggatt gcgatgattc agcttccgta       60

aatcagtcag aaggcgtggt accacgcttt c                                      91


<210>  24
<211>  112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  24
tgactgattt acggaagctg aataaggact gcttaggatt gcgatgattc agcttccgta       60

aatcagtcag aagctgaata aggactgctt aggattgcga tgattcagct tc              112


<210>  25
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  25
tcacctgaga cttgacgatg gcatcactcc cccccaccta ttacatcatc ataaattgag       60

tgctatcgtc tgtcca                                                       76


<210>  26
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  26
tcacctgaga cttgacgatg gcctccccct cacgcactct tccgtttctt cttatctgag       60

tgctatcgtc tgtcca                                                       76


<210>  27
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  27
tcacctgaga cttgacgatg gaactccccc caccattatc agcgcaccac cattgtagag       60

tgctatcgtc tgtcca                                                       76


<210>  28
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  28
tcacctgaga cttgacgatg gtttaactcc cccacgcccc ccgccaaccc atctccagag       60

tgctatcgtc tgtcca                                                       76


<210>  29
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  29
tcacctgaga cttgacgatg gtacgacggc cccccgatta tgcgactact tgatttgagt       60

gctatcgtct gtcca                                                        75


<210>  30
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  30
tcacctgaga cttgacgatg gtcagaacga cgcgcccccc acctcattca ttattttgag       60

tgctatcgtc tgtcca                                                       76


<210>  31
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  31
tcacctgaga cttgacgatg gtgaccaccc cccacgcaca cacacctctt ccatcctgag       60

tgctatcgtc tgtcca                                                       76


<210>  32
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  32
tcacctgaga cttgacgatg gcactacccc tccctactaa gcacggtatc ttgtactgag       60

tgctatcgtc tgtcca                                                       76


<210>  33
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  33
tcacctgaga cttgacgatg ggaacaaaca ccgcgaccac ccccccactt aactcctgag       60

tgctatcgtc tgtcca                                                       76


<210>  34
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  34
tcacctgaga cttgacgatg gcaatccccc cgacaccgaa tcctaagcga acaacgcgag       60

tgctatcgtc tgtcca                                                       76


<210>  35
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  35
tcacctgaga cttgacgatg gactcacaaa ctcgagccac ccccgaccca cacaacagag       60

tgctatcgtc tgtcca                                                       76


<210>  36
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  36
tcacctgaga cttgacgatg gtactccccc ccaacctaat agctctttac cctctgagag       60

tgctatcgtc tgtcca                                                       76


<210>  37
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  37
tcacctgaga cttgacgatg gccgactccc caccctacat cgcaacattg actattagag       60

tgctatcgtc tgtcca                                                       76


<210>  38
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  38
tcacctgaga cttgacgatg gttctacact gcccccccga cccgccagac caacccagag       60

tgctatcgtc tgtcca                                                       76


<210>  39
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  39
tcacctgaga cttgacgatg gcaatcctcc gagctccacc cacccttact caacattgag       60

tgctatcgtc tgtcca                                                       76


<210>  40
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  40
tcacctgaga cttgacgatg gcgctacccc ctaacttcaa cccgcattat tctagctgag       60

tgctatcgtc tgtcca                                                       76


<210>  41
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  41
tcacctgaga cttgacgatg gttaccgaac ccgacacccc cgccgacacc agccccagag       60

tgctatcgtc tgtcca                                                       76


<210>  42
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  42
tcacctgaga cttgacgatg gccccccccc gcaccgcctc attcagcata ctaatacgag       60

tgctatcgtc tgtcca                                                       76


<210>  43
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  43
tcacctgaga cttgacgatg gcaaccaccc cccctggcta catcatattc ttatcttgag       60

tgctatcgtc tgtcca                                                       76


<210>  44
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  44
tcacctgaga cttgacgatg gtttcttcgc cccccccaca cactacacgt ttcttctgag       60

tgctatcgtc tgtcca                                                       76


<210>  45
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  45
tcacctgaga cttgacgatg gttacctcac acccccccgc acgcactacc cccgcccgag       60

tgctatcgtc tgtcca                                                       76


<210>  46
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  46
tcacctgaga cttgacgatg gtttaactcc cccacgcccc ccgccaaccc atctccagag       60

tgctatcgtc tgtcca                                                       76


<210>  47
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  47
tcacctgaga cttgacgatg gtgaccaccc cccacgcaca cacacctctt ccatcctgag       60

tgctatcgtc tgtcca                                                       76


<210>  48
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  48
tcacctgaga cttgacgatg gtctaattcg caccccccct ctactcgcca ccccccagag       60

tgctatcgtc tgtcca                                                       76


<210>  49
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  49
tcacctgaga cttgacgatg gtgttgtttt ccaccctact cgccgccccc ccgacccgag       60

tgctatcgtc tgtcca                                                       76


<210>  50
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  50
tcacctgaga cttgacgatg gtaacgaacc gcgcccacca cacgcccacc cccccacgag       60

tgctatcgtc tgtcca                                                       76


<210>  51
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  51
tcacctgaga cttgacgatg gtccacgtta ccgcacaccc gccgacaccc ccgcctcgag       60

tgctatcgtc tgtcca                                                       76


<210>  52
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  52
tcacctgaga cttgacgatg gtgaccaccc cccacgcaca cacacccctt ccatcctgag       60

tgctatcgtc tgtcca                                                       76


<210>  53
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  53
tcacctgaga cttgacgatg gactaccgca ccaccaccac acccccccga ccgcactgag       60

tgctatcgtc tgtcca                                                       76


<210>  54
<211>  76
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  54
tcacctgaga cttgacgatg gtaacctcac ccgcatcccc ccccagttca attattagag       60

tgctatcgtc tgtcca                                                       76


<210>  55
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  55
gacttgacga tggcatcact cccccccacc tattacatca tcataaattg agtgctatcg       60

tctgtc                                                                  66


<210>  56
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  56
gacgatggca tcactccccc ccacctatta catcatcata aattgagtgc tatcgtc          57


<210>  57
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aptamer

<400>  57
gacgatagca tcactccccc ccacctatta catcatcata aattgagtgc tatcgtc          57


