<110>    GenoPharm Inc.
         ABION Inc.

<120>    Recombinant protein fused with interferon-beta mutein and
         antibody, and pharmaceutical composition comprising the same

<130>    OP21-0006/PCT

<150>    KR 10-2020-0052911
<151>    2020-04-29

<160>    11

<170>    KoPatentIn 3.0

<210>    1
<211>    166
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of interferon beta mutein


<400>    1
Met Ser Tyr Asn Leu Leu Gly Phe Leu Gln Arg Ser Ser Asn Phe Gln
  1               5                  10                  15 

Ser Gln Lys Leu Leu Trp Gln Leu Asn Gly Thr Leu Glu Tyr Cys Leu
             20                  25                  30 

Lys Asp Arg Met Asn Phe Asp Ile Pro Glu Glu Ile Lys Gln Leu Gln
         35                  40                  45 

Gln Phe Gln Lys Glu Asp Ala Ala Leu Thr Ile Tyr Glu Met Leu Gln
     50                  55                  60 

Asn Ile Phe Ala Ile Phe Arg Gln Asp Ser Ser Ser Thr Gly Trp Asn
 65                  70                  75                  80 

Glu Thr Ile Val Glu Asn Leu Leu Ala Asn Val Tyr His Gln Ile Asn
                 85                  90                  95 

His Leu Lys Thr Val Leu Glu Glu Lys Leu Glu Lys Glu Asp Phe Thr
            100                 105                 110 

Arg Gly Lys Leu Met Ser Ser Leu His Leu Lys Arg Tyr Tyr Gly Arg
        115                 120                 125 

Ile Leu His Tyr Leu Lys Ala Lys Glu Tyr Ser His Cys Ala Trp Thr
    130                 135                 140 

Ile Val Arg Val Glu Ile Leu Arg Asn Phe Tyr Phe Ile Asn Arg Leu
145                 150                 155                 160 

Thr Gly Tyr Leu Arg Asn
                165    


<210>    2
<211>    501
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Polynucleotide sequence of interferon beta mutein


<400>    2
atgtcctaca acctgctggg cttcctgcag cggtcctcca acttccagag ccagaaactg         60

ctgtggcagc tgaatggcac cctggaatac tgcctgaagg accggatgaa cttcgacatc        120

cccgaggaaa tcaagcagct gcagcagttc cagaaagagg acgccgctct gaccatctac        180

gagatgctgc agaacatctt cgccatcttc cggcaggact cctcctccac cggctggaac        240

gagacaatcg tggaaaatct gctggccaac gtgtaccacc agatcaacca cctgaaaacc        300

gtgctggaag agaagctgga aaaagaggac ttcacccggg gcaagctgat gtcctccctg        360

cacctgaagc ggtactacgg ccggatcctg cactacctga aggccaaaga atactcccac        420

tgcgcctgga ccatcgtgcg ggtggaaatc ctgcggaact tctactttat caaccggctg        480

accggctacc tgaggaactg a                                                  501


<210>    3
<211>    450
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Trastuzumab heavy chain


<400>    3
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr
             20                  25                  30 

Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln
            100                 105                 110 

Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
        115                 120                 125 

Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala
    130                 135                 140 

Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser
145                 150                 155                 160 

Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val
                165                 170                 175 

Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro
            180                 185                 190 

Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys
        195                 200                 205 

Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp
    210                 215                 220 

Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly
225                 230                 235                 240 

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile
                245                 250                 255 

Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu
            260                 265                 270 

Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
        275                 280                 285 

Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg
    290                 295                 300 

Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys
305                 310                 315                 320 

Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu
                325                 330                 335 

Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
            340                 345                 350 

Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
        355                 360                 365 

Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp
    370                 375                 380 

Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val
385                 390                 395                 400 

Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp
                405                 410                 415 

Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His
            420                 425                 430 

Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro
        435                 440                 445 

Gly Lys
    450


<210>    4
<211>    214
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Trastuzumab light chain


<400>    4
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys
    210                


<210>    5
<211>    449
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Cetuximab heavy chain


<400>    5
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln
  1               5                  10                  15 

Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asn Tyr
             20                  25                  30 

Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu
         35                  40                  45 

Gly Val Ile Trp Ser Gly Gly Asn Thr Asp Tyr Asn Thr Pro Phe Thr
     50                  55                  60 

Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Phe
 65                  70                  75                  80 

Lys Met Asn Ser Leu Gln Ser Asn Asp Thr Ala Ile Tyr Tyr Cys Ala
                 85                  90                  95 

Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110 

Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe
        115                 120                 125 

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu
    130                 135                 140 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu
                165                 170                 175 

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser
            180                 185                 190 

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro
        195                 200                 205 

Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
    210                 215                 220 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser
                245                 250                 255 

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
            260                 265                 270 

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn
        275                 280                 285 

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val
    290                 295                 300 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                325                 330                 335 

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
            340                 345                 350 

Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr
        355                 360                 365 

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu
    370                 375                 380 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys
                405                 410                 415 

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu
            420                 425                 430 

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
        435                 440                 445 

Lys
   


<210>    6
<211>    214
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Cetuximab light chain


<400>    6
Asp Ile Leu Leu Thr Gln Ser Pro Val Ile Leu Ser Val Ser Pro Gly
  1               5                  10                  15 

Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Asn
             20                  25                  30 

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile
         35                  40                  45 

Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser
 65                  70                  75                  80 

Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Asn Asn Asn Trp Pro Thr
                 85                  90                  95 

Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys
    210                


<210>    7
<211>    448
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Atezolizumab heavy chain


<400>    7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
             20                  25                  30 

Trp Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ala Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg Arg His Trp Pro Gly Gly Phe Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110 

Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125 

Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140 

Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160 

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175 

Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190 

Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205 

Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220 

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255 

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270 

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285 

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr Arg Val Val
    290                 295                 300 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335 

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350 

Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415 

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430 

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445 




<210>    8
<211>    214
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence of Atezolizumab light chain


<400>    8
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
  1               5                  10                  15 

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Ser Thr Ala
             20                  25                  30 

Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
         35                  40                  45 

Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly
     50                  55                  60 

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
 65                  70                  75                  80 

Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Leu Tyr His Pro Ala
                 85                  90                  95 

Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110 

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125 

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                165                 170                 175 

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190 

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205 

Phe Asn Arg Gly Glu Cys
    210                


<210>    9
<211>    1896
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Polynucleotide sequence of Trastuzumab-interferon beta mutein
         heavy chain


<400>    9
gaggtgcagc tggtggaatc tggcggagga ctggtgcagc ctggcggctc tctgagactg         60

tcttgtgccg cctccggctt caacatcaag gacacctaca tccactgggt gcgacaggcc        120

cctggcaagg gactggaatg ggtggcccgg atctatccca ccaacggcta caccagatac        180

gccgactctg tgaagggccg gttcaccatc tccgccgaca cctccaagaa caccgcctac        240

ctgcagatga actccctgcg ggccgaggac accgccgtgt actactgctc tagatgggga        300

ggcgacggct tctacgccat ggactattgg ggccagggca ccctcgtgac cgtgtcctct        360

gcttctacca agggcccctc cgtgttccct ctggcccctt ccagcaagtc tacctctggc        420

ggcacagccg ctctgggctg cctcgtgaag gactacttcc ccgagcccgt gacagtgtct        480

tggaactctg gcgccctgac ctccggcgtg cacacctttc cagctgtgct gcagtccagc        540

ggcctgtact ccctgtcctc cgtcgtgact gtgccctcca gctctctggg cacccagacc        600

tacatctgca acgtgaacca caagccctcc aacaccaagg tggacaagaa ggtggaaccc        660

aagtcctgcg acaagaccca cacctgtccc ccttgtcctg cccctgaact gctgggcgga        720

cccagcgtgt tcctgttccc cccaaagcct aaggacaccc tgatgatctc ccggaccccc        780

gaagtgacct gcgtggtggt ggatgtgtcc cacgaggacc ctgaagtgaa gttcaattgg        840

tacgtggacg gcgtggaagt gcacaacgcc aagaccaagc ctagagagga acagtacaac        900

tccacctacc gggtggtgtc cgtgctgacc gtgctgcatc aggactggct gaacggcaaa        960

gagtacaagt gcaaggtgtc caacaaggcc ctgcctgccc ccatcgaaaa gaccatctcc       1020

aaggccaagg gccagccccg ggaaccccag gtgtacacac tgccccctag ccgggaagag       1080

atgaccaaga accaggtgtc cctgacctgt ctcgtgaaag gcttctaccc ctccgatatc       1140

gccgtggaat gggagtccaa cggccagcct gagaacaact acaagaccac cccccctgtg       1200

ctggactccg acggctcatt cttcctgtac agcaagctga cagtggacaa gtcccggtgg       1260

cagcagggca acgtgttctc ctgctccgtg atgcacgagg ccctgcacaa ccactacacc       1320

cagaagtccc tgtccctgtc tcccggaaaa ggcggaggcg gatctggcgg cggtggttca       1380

ggcggtggat ccggcatgtc ctacaacctg ctgggcttcc tgcagcggtc ctccaacttc       1440

cagtcccaga aactgctgtg gcagctgaat ggcaccctgg aatactgcct gaaggaccgg       1500

atgaacttcg acatccccga ggaaatcaag cagctgcagc agttccagaa agaggacgcc       1560

gctctgacca tctacgagat gctgcagaac atcttcgcca tcttccggca ggactcctcc       1620

tccaccggct ggaacgagac aatcgtggaa aatctgctgg ccaacgtgta ccaccagatc       1680

aaccacctga aaaccgtgct ggaagagaag ctggaaaaag aggacttcac ccggggcaag       1740

ctgatgtcct ccctgcacct gaagcggtac tacggccgga tcctgcacta cctgaaggcc       1800

aaagaatact cccactgcgc ctggaccatc gtgcgggtgg aaatcctgcg gaacttctac       1860

tttatcaacc ggctgaccgg ctacctgagg aactga                                 1896


<210>    10
<211>    1893
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Polynucleotide sequence of Cetuximab-interferon beta mutein heavy
         chain


<400>    10
caggtgcagc tgaagcagtc tggccctgga ctggtgcagc cttcccagtc cctgtccatc         60

acctgtaccg tgtccggctt ctccctgacc aactacggcg tgcactgggt gcgacagtct        120

ccaggcaagg gcctggaatg gctgggagtg atttggagcg gcggcaacac cgactacaac        180

acccctttca cctcccggct gagcatcaac aaggacaact ccaagtccca ggtgttcttc        240

aagatgaact ccctgcagtc caacgacacc gccatctact actgcgccag agccctgacc        300

tactatgact acgagttcgc ctactggggc cagggcaccc tcgtgacagt gtctgccgct        360

tctaccaagg gcccctccgt gtttcctctg gccccttcca gcaagtccac ctctggcgga        420

acagccgctc tgggctgcct cgtgaaggac tacttccccg agcccgtgac cgtgtcctgg        480

aattctggcg ctctgaccag cggagtgcac accttccctg ctgtgctgca gtcctccggc        540

ctgtactccc tgtcctccgt cgtgactgtg ccctccagct ctctgggcac ccagacctac        600

atctgcaacg tgaaccacaa gccctccaac accaaggtgg acaagaaggt ggaacccaag        660

tcctgcgaca agacccacac ctgtccccct tgtcctgccc ctgaactgct gggcggacct        720

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatctcccg gacccccgaa        780

gtgacctgcg tggtggtgga tgtgtcccac gaggaccctg aagtgaagtt caattggtac        840

gtggacggcg tggaagtgca caacgccaag accaagccta gagaggaaca gtacaactcc        900

acctaccggg tggtgtccgt gctgaccgtg ctgcatcagg actggctgaa cggcaaagag        960

tacaagtgca aggtgtccaa caaggccctg cctgccccca tcgaaaagac catctccaag       1020

gccaagggac agccccgcga gccccaggtg tacacactgc ctccatctcg ggacgagctg       1080

accaagaacc aggtgtccct gacctgtctc gtgaaaggct tctacccctc cgacattgcc       1140

gtggaatggg agtccaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg       1200

gactccgacg gctcattctt cctgtacagc aagctgacag tggacaagtc ccggtggcag       1260

cagggcaacg tgttctcctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag       1320

aagtccctga gcctgagccc tggaaaaggc ggcggaggat ctggcggagg cggttctggt       1380

ggcggctctg gcatgtccta caacctgctg ggcttcctgc agcggtcctc caacttccag       1440

agccagaaac tgctgtggca gctgaatggc accctggaat actgcctgaa ggaccggatg       1500

aacttcgaca tccccgagga aatcaagcag ctgcagcagt tccagaaaga ggacgccgcc       1560

ctgacaatct acgagatgct gcagaacatc ttcgccatct tccggcagga ctcctcctcc       1620

accggctgga acgagacaat cgtggaaaat ctgctggcca acgtgtacca ccagatcaac       1680

cacctgaaaa ccgtgctgga agagaagctg gaaaaagagg acttcacccg gggcaagctg       1740

atgtcctccc tgcacctgaa gcggtactac ggccggatcc tgcactacct gaaggccaaa       1800

gaatactccc actgcgcctg gaccatcgtg cgggtggaaa tcctgcggaa cttctacttt       1860

atcaaccggc tgaccggcta cctgaggaac tga                                    1893


<210>    11
<211>    1890
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Polynucleotide sequence of Atezolizumab-interferon beta mutein
         heavy chain


<400>    11
gaggtgcagc tggttgaatc tggcggagga ttggttcagc ctggcggctc tctgagactg         60

tcttgtgccg cttccggctt taccttctcc gactcctgga tccactgggt ccgacaggca        120

cctggcaaag gactggaatg ggtcgcctgg atctctcctt acggcggctc tacctactac        180

gccgactctg tgaagggcag attcaccatc tccgccgaca cctccaagaa caccgcctac        240

ctgcagatga actccctgag agccgaggac accgccgtgt actactgtgc tagaaggcat        300

tggccaggcg gcttcgatta ttggggccag ggaacactgg tcaccgtgtc ctctgcttcc        360

accaagggac cctctgtgtt ccctctggct ccttccagca agtctacctc tggcggaaca        420

gctgctctgg gctgcctggt caaggactac tttcctgagc ctgtgaccgt gtcttggaac        480

tctggcgctc tgacatccgg cgtgcacacc tttccagctg tgctgcaatc cagcggcctg        540

tactctctgt cctccgtcgt gaccgtgcct tcttctagcc tgggcaccca gacctacatc        600

tgcaatgtga accacaagcc ttccaacacc aaggtggaca agaaggtgga acccaagtcc        660

tgcgacaaga cccacacctg tcctccatgt cctgctccag aactgctcgg cggaccttcc        720

gtgttcctgt ttcctccaaa gcctaaggac accctgatga tctctcggac ccctgaagtg        780

acctgcgtgg tggtggatgt gtctcacgag gatcccgaag tgaagttcaa ttggtacgtg        840

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta cgcctccacc        900

tacagagtgg tgtccgtgct gacagtgctg caccaggatt ggctgaacgg caaagagtac        960

aagtgcaagg tgtccaacaa ggccctgcct gctcctatcg aaaagaccat ctccaaggcc       1020

aagggccagc ctcgagaacc ccaggtttac accctgcctc caagccggga agagatgacc       1080

aagaaccagg tgtccctgac ctgcctcgtg aagggcttct acccttccga cattgccgtg       1140

gaatgggaga gcaatggcca gccagagaac aactacaaga caacccctcc tgtgctggac       1200

tccgacggct cattcttcct gtactccaag ctgaccgtgg acaagtccag atggcagcag       1260

ggcaacgtgt tctcctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag       1320

tccctgtctc tgagcccagg caaaggcgga ggtggtagcg gcggaggcgg aagtggcggt       1380

ggatctggca tgtcttacaa cctgctgggc ttcctgcagc ggtcctccaa cttccagagc       1440

cagaaactgc tgtggcagct gaatggcacc ctggaatact gcctgaagga ccggatgaac       1500

ttcgacatcc ccgaggaaat caagcagctg cagcagttcc agaaagagga cgccgctctg       1560

accatctacg agatgctgca gaacatcttc gccatcttcc ggcaggactc ctcctctacc       1620

ggctggaacg agacaatcgt ggaaaatctg ctggccaacg tgtaccacca gatcaaccac       1680

ctgaaaaccg tgctggaaga gaagctggaa aaagaggact tcacccgggg caagctgatg       1740

tcctctctgc acctgaagcg gtactacggc cggatcctgc actacctgaa ggccaaagaa       1800

tactcccact gcgcctggac catcgtgcgc gtggaaatcc tgcggaactt ctacttcatc       1860

aaccggctga ccggctacct gagaaactga                                        1890
