                         SEQUENCE LISTING

<110>  Pfizer Inc.
       Barber, Joyann
       Cho-Schultz, Sujin
       Del Bel, Matthew L.
       Gallego, Rebecca Anne
       He, Mingying
       Jalaie, Mehran
       Kania, Robert Steven
       McTigue, Michele Ann
       Nair, Sajiv Krishnan
       Schmitt, Anne-Marie Dechert
       Tuttle, Jamison Bryce
       Zhou, Dahui
       Zhou, Ru
 
<120>  Azalactam  Compounds as HPK1 Inhibitors

<130>  PC72605A

<150>  US 63/018,689
<151>  2020-05-01

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  2472
<212>  DNA
<213>  Homo sapiens

<400>  1
ggatccatgg acgtcgtgga ccctgacatt ttcaatagag acccccggga ccactatgac       60

ctgctacagc ggctgggtgg cggcacgtat ggggaagtct ttaaggctcg cgacaaggtg      120

tcaggggacc tggtggcact gaagatggtg aagatggagc ctgatgatga tgtctccacc      180

cttcagaagg aaatcctcat attgaaaact tgccggcacg ccaacatcgt ggcctaccac      240

gggagttatc tctggttgca gaaactctgg atctgcatgg agttctgtgg ggctggttct      300

ctccaggaca tctaccaagt gacaggctcc ctgtcagagc tccagattag ctatgtctgc      360

cgggaagtgc tccagggact ggcctatttg cactcacaga agaagataca cagggacatc      420

aagggagcta acatcctcat caatgatgct ggggaggtca gattggctga ctttggcatc      480

tcggcccaga ttggggctac actggccaga cgcctctctt tcattgggac accctactgg      540

atggctccgg aagtggcagc tgtggccctg aagggaggat acaatgagct gtgtgacatc      600

tggtccctgg gcatcacggc catcgaactg gccgagctac agccaccgct ctttgatgtg      660

caccctctca gagttctctt cctcatgacc aagagtggct accagcctcc ccgactgaag      720

gaaaaaggca aatggtcggc tgccttccac aacttcatca aagtcactct gactaagagt      780

cccaagaaac gacccagcgc caccaagatg ctcagtcatc aactggtatc ccagcctggg      840

ctgaatcgag gcctgatcct ggatcttctt gacaaactga agaatcccgg gaaaggaccc      900

tccattgggg acattgagga tgaggagccc gagctacccc ctgctatccc tcggcggatc      960

agatccaccc accgctccag ctctctgggc atcccagatg cagactgctg tcggcggcac     1020

atggagttca ggaagctccg aggaatggag accagacccc cagccaacac cgctcgccta     1080

cagcctcccc gagacctcag gagcagcagc cccaggaagc aactgtcaga gtcgtctgac     1140

gatgactatg acgacgtgga catccccacc cctgcagagg acacacctcc tccacttccc     1200

cccaagccca agttccgttc tccatcagac gagggtcctg ggagcatggg ggatgatggg     1260

cagctgagcc cgggggtgct ggtccggtgt gccagtgggc ccccaccaaa cagcccccgt     1320

cctgggcctc ccccatccac cagcagcccc cacctcaccg cccattcaga accctcactc     1380

tggaacccac cctcccggga gcttgacaag cccccacttc tgccccccaa gaaggaaaag     1440

atgaagagaa agggatgtgc ccttctcgta aagttgttca atggctgccc cctccgcatc     1500

cacagcacgg ccgcctggac acatccctcc accaaggacc agcacctgct cctgggggca     1560

gaggaaggca tcttcatcct gaaccggaat gaccaggagg ccacgctgga aatgctcttt     1620

cctagccgga ctacgtgggt gtactccatc aacaacgttc tcatgtctct ctcaggaaag     1680

accccccacc tgtattctca tagcatcctt ggcctgctgg aacggaaaga gaccagagca     1740

ggaaacccca tcgctcacat tagcccccac cgcctactgg caaggaagaa catggtttcc     1800

accaagatcc aggacaccaa aggctgccgg gcgtgctgtg tggcggaggg tgcgagctct     1860

gggggcccgt tcctgtgcgg tgcattggag acgtccgttg tcctgcttca gtggtaccag     1920

cccatgaaca aattcctgct tgtccggcag gtgctgttcc cactgccgac gcctctgtcc     1980

gtgttcgcgc tgctgaccgg gccaggctct gagctgcccg ctgtgtgcat cggcgtgagc     2040

cccgggcggc cggggaagtc ggtgctcttc cacacggtgc gctttggcgc gctctcttgc     2100

tggctgggcg agatgagcac cgagcacagg ggacccgtgc aggtgaccca ggtagaggaa     2160

gatatggtga tggtgttgat ggatggctct gtgaagctgg tgaccccgga ggggtcccca     2220

gtccggggac ttcgcacacc tgagatcccc atgaccgaag cggtggaggc cgtggctatg     2280

gttggaggtc agcttcaggc cttctggaag catggagtgc aggtgtgggc tctaggctcg     2340

gatcagctgc tacaggagct gagagaccct accctcactt tccgtctgct tggctccccc     2400

aggcctgtag tggtggagac acgcccagtg gatgatccta ctgctcccag caacctctac     2460

atccaggaat ga                                                         2472


<210>  2
<211>  823
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ser Met Asp Val Val Asp Pro Asp Ile Phe Asn Arg Asp Pro Arg 
1               5                   10                  15      


Asp His Tyr Asp Leu Leu Gln Arg Leu Gly Gly Gly Thr Tyr Gly Glu 
            20                  25                  30          


Val Phe Lys Ala Arg Asp Lys Val Ser Gly Asp Leu Val Ala Leu Lys 
        35                  40                  45              


Met Val Lys Met Glu Pro Asp Asp Asp Val Ser Thr Leu Gln Lys Glu 
    50                  55                  60                  


Ile Leu Ile Leu Lys Thr Cys Arg His Ala Asn Ile Val Ala Tyr His 
65                  70                  75                  80  


Gly Ser Tyr Leu Trp Leu Gln Lys Leu Trp Ile Cys Met Glu Phe Cys 
                85                  90                  95      


Gly Ala Gly Ser Leu Gln Asp Ile Tyr Gln Val Thr Gly Ser Leu Ser 
            100                 105                 110         


Glu Leu Gln Ile Ser Tyr Val Cys Arg Glu Val Leu Gln Gly Leu Ala 
        115                 120                 125             


Tyr Leu His Ser Gln Lys Lys Ile His Arg Asp Ile Lys Gly Ala Asn 
    130                 135                 140                 


Ile Leu Ile Asn Asp Ala Gly Glu Val Arg Leu Ala Asp Phe Gly Ile 
145                 150                 155                 160 


Ser Ala Gln Ile Gly Ala Thr Leu Ala Arg Arg Leu Ser Phe Ile Gly 
                165                 170                 175     


Thr Pro Tyr Trp Met Ala Pro Glu Val Ala Ala Val Ala Leu Lys Gly 
            180                 185                 190         


Gly Tyr Asn Glu Leu Cys Asp Ile Trp Ser Leu Gly Ile Thr Ala Ile 
        195                 200                 205             


Glu Leu Ala Glu Leu Gln Pro Pro Leu Phe Asp Val His Pro Leu Arg 
    210                 215                 220                 


Val Leu Phe Leu Met Thr Lys Ser Gly Tyr Gln Pro Pro Arg Leu Lys 
225                 230                 235                 240 


Glu Lys Gly Lys Trp Ser Ala Ala Phe His Asn Phe Ile Lys Val Thr 
                245                 250                 255     


Leu Thr Lys Ser Pro Lys Lys Arg Pro Ser Ala Thr Lys Met Leu Ser 
            260                 265                 270         


His Gln Leu Val Ser Gln Pro Gly Leu Asn Arg Gly Leu Ile Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Leu Lys Asn Pro Gly Lys Gly Pro Ser Ile Gly Asp 
    290                 295                 300                 


Ile Glu Asp Glu Glu Pro Glu Leu Pro Pro Ala Ile Pro Arg Arg Ile 
305                 310                 315                 320 


Arg Ser Thr His Arg Ser Ser Ser Leu Gly Ile Pro Asp Ala Asp Cys 
                325                 330                 335     


Cys Arg Arg His Met Glu Phe Arg Lys Leu Arg Gly Met Glu Thr Arg 
            340                 345                 350         


Pro Pro Ala Asn Thr Ala Arg Leu Gln Pro Pro Arg Asp Leu Arg Ser 
        355                 360                 365             


Ser Ser Pro Arg Lys Gln Leu Ser Glu Ser Ser Asp Asp Asp Tyr Asp 
    370                 375                 380                 


Asp Val Asp Ile Pro Thr Pro Ala Glu Asp Thr Pro Pro Pro Leu Pro 
385                 390                 395                 400 


Pro Lys Pro Lys Phe Arg Ser Pro Ser Asp Glu Gly Pro Gly Ser Met 
                405                 410                 415     


Gly Asp Asp Gly Gln Leu Ser Pro Gly Val Leu Val Arg Cys Ala Ser 
            420                 425                 430         


Gly Pro Pro Pro Asn Ser Pro Arg Pro Gly Pro Pro Pro Ser Thr Ser 
        435                 440                 445             


Ser Pro His Leu Thr Ala His Ser Glu Pro Ser Leu Trp Asn Pro Pro 
    450                 455                 460                 


Ser Arg Glu Leu Asp Lys Pro Pro Leu Leu Pro Pro Lys Lys Glu Lys 
465                 470                 475                 480 


Met Lys Arg Lys Gly Cys Ala Leu Leu Val Lys Leu Phe Asn Gly Cys 
                485                 490                 495     


Pro Leu Arg Ile His Ser Thr Ala Ala Trp Thr His Pro Ser Thr Lys 
            500                 505                 510         


Asp Gln His Leu Leu Leu Gly Ala Glu Glu Gly Ile Phe Ile Leu Asn 
        515                 520                 525             


Arg Asn Asp Gln Glu Ala Thr Leu Glu Met Leu Phe Pro Ser Arg Thr 
    530                 535                 540                 


Thr Trp Val Tyr Ser Ile Asn Asn Val Leu Met Ser Leu Ser Gly Lys 
545                 550                 555                 560 


Thr Pro His Leu Tyr Ser His Ser Ile Leu Gly Leu Leu Glu Arg Lys 
                565                 570                 575     


Glu Thr Arg Ala Gly Asn Pro Ile Ala His Ile Ser Pro His Arg Leu 
            580                 585                 590         


Leu Ala Arg Lys Asn Met Val Ser Thr Lys Ile Gln Asp Thr Lys Gly 
        595                 600                 605             


Cys Arg Ala Cys Cys Val Ala Glu Gly Ala Ser Ser Gly Gly Pro Phe 
    610                 615                 620                 


Leu Cys Gly Ala Leu Glu Thr Ser Val Val Leu Leu Gln Trp Tyr Gln 
625                 630                 635                 640 


Pro Met Asn Lys Phe Leu Leu Val Arg Gln Val Leu Phe Pro Leu Pro 
                645                 650                 655     


Thr Pro Leu Ser Val Phe Ala Leu Leu Thr Gly Pro Gly Ser Glu Leu 
            660                 665                 670         


Pro Ala Val Cys Ile Gly Val Ser Pro Gly Arg Pro Gly Lys Ser Val 
        675                 680                 685             


Leu Phe His Thr Val Arg Phe Gly Ala Leu Ser Cys Trp Leu Gly Glu 
    690                 695                 700                 


Met Ser Thr Glu His Arg Gly Pro Val Gln Val Thr Gln Val Glu Glu 
705                 710                 715                 720 


Asp Met Val Met Val Leu Met Asp Gly Ser Val Lys Leu Val Thr Pro 
                725                 730                 735     


Glu Gly Ser Pro Val Arg Gly Leu Arg Thr Pro Glu Ile Pro Met Thr 
            740                 745                 750         


Glu Ala Val Glu Ala Val Ala Met Val Gly Gly Gln Leu Gln Ala Phe 
        755                 760                 765             


Trp Lys His Gly Val Gln Val Trp Ala Leu Gly Ser Asp Gln Leu Leu 
    770                 775                 780                 


Gln Glu Leu Arg Asp Pro Thr Leu Thr Phe Arg Leu Leu Gly Ser Pro 
785                 790                 795                 800 


Arg Pro Val Val Val Glu Thr Arg Pro Val Asp Asp Pro Thr Ala Pro 
                805                 810                 815     


Ser Asn Leu Tyr Ile Gln Glu 
            820             


<210>  3
<211>  66
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcgtcgc atcaccatca ccatcacgat tacgatggtg ctacgaccga aaacctgtat       60

tttcag                                                                  66


<210>  4
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ser His His His His His His Asp Tyr Asp Gly Ala Thr Thr 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln 
            20          


