                         SEQUENCE LISTING

<110>  Novartis AG
       Intellia Therapeutics, Inc.
       Heyder, Jessica
       Lacoste, Arnaud
 
<120>  METHODS AND COMPOSITIONS FOR OCULAR CELL THERAPY

<130>  PAT058807-US-PSP

<160>  183   

<170>  PatentIn version 3.5

<210>  1
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys 
1               5                   10                  15      


Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln 
            20                  25                  30          


Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala 
        35                  40                  45              


Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln 
    50                  55                  60                  


Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu 
65                  70                  75                  80  


Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg 
                85                  90                  95      


Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala 
            100                 105                 110         


Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn 
        115                 120                 125             


Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln 
    130                 135                 140                 


Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn 
145                 150                 155                 160 


Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln 
                165                 170                 175     


Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro 
            180                 185                 190         


Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln 
        195                 200                 205             


Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val 
    210                 215                 220                 


Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro 
                245                 250                 255     


Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser 
            260                 265                 270         


Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile 
        275                 280                 285             


Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro 
    290                 295                 300                 


Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile 
305                 310                 315                 320 


Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser 
                325                 330                 335     


Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly 
            340                 345                 350         


Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val 
        355                 360                 365             


Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln 
    370                 375                 380                 


Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr 
385                 390                 395                 400 


Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser 
                405                 410                 415     


His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn 
            420                 425                 430         


Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly 
        435                 440                 445             


His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser 
    450                 455                 460                 


Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln 
465                 470                 475                 480 


Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln 
                485                 490                 495     


Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu 
            500                 505                 510         


Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln 
        515                 520                 525             


Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro 
    530                 535                 540                 


Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro 
545                 550                 555                 560 


Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile 
                565                 570                 575     


Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu 
            580                 585                 590         


Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys 
        595                 600                 605             


Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu 
    610                 615                 620                 


Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys 
625                 630                 635                 640 


Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln 
                645                 650                 655     


Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Gly 
            660                 665                 670         


Leu Ser Gln Asp Ala Gln Asp Gln Met Arg Lys Met Leu Cys Gln Lys 
        675                 680                 685             


Glu Ser Asn Tyr Ile Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met 
    690                 695                 700                 


Phe Val Lys Ile Lys Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys 
705                 710                 715                 720 


Leu Ala Arg Lys Val Asp Thr Lys Ala Leu Tyr Ala Thr Lys Thr Leu 
                725                 730                 735     


Arg Lys Lys Asp Val Leu Leu Arg Asn Gln Val Ala His Val Lys Ala 
            740                 745                 750         


Glu Arg Asp Ile Leu Ala Glu Ala Asp Asn Glu Trp Val Val Arg Leu 
        755                 760                 765             


Tyr Tyr Ser Phe Gln Asp Lys Asp Asn Leu Tyr Phe Val Met Asp Tyr 
    770                 775                 780                 


Ile Pro Gly Gly Asp Met Met Ser Leu Leu Ile Arg Met Gly Ile Phe 
785                 790                 795                 800 


Pro Glu Ser Leu Ala Arg Phe Tyr Ile Ala Glu Leu Thr Cys Ala Val 
                805                 810                 815     


Glu Ser Val His Lys Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp 
            820                 825                 830         


Asn Ile Leu Ile Asp Arg Asp Gly His Ile Lys Leu Thr Asp Phe Gly 
        835                 840                 845             


Leu Cys Thr Gly Phe Arg Trp Thr His Asp Ser Lys Tyr Tyr Gln Ser 
    850                 855                 860                 


Gly Asp His Pro Arg Gln Asp Ser Met Asp Phe Ser Asn Glu Trp Gly 
865                 870                 875                 880 


Asp Pro Ser Ser Cys Arg Cys Gly Asp Arg Leu Lys Pro Leu Glu Arg 
                885                 890                 895     


Arg Ala Ala Arg Gln His Gln Arg Cys Leu Ala His Ser Leu Val Gly 
            900                 905                 910         


Thr Pro Asn Tyr Ile Ala Pro Glu Val Leu Leu Arg Thr Gly Tyr Thr 
        915                 920                 925             


Gln Leu Cys Asp Trp Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu 
    930                 935                 940                 


Val Gly Gln Pro Pro Phe Leu Ala Gln Thr Pro Leu Glu Thr Gln Met 
945                 950                 955                 960 


Lys Val Ile Asn Trp Gln Thr Ser Leu His Ile Pro Pro Gln Ala Lys 
                965                 970                 975     


Leu Ser Pro Glu Ala Ser Asp Leu Ile Ile Lys Leu Cys Arg Gly Pro 
            980                 985                 990         


Glu Asp Arg Leu Gly Lys Asn Gly  Ala Asp Glu Ile Lys  Ala His Pro 
        995                 1000                 1005             


Phe Phe  Lys Thr Ile Asp Phe  Ser Ser Asp Leu Arg  Gln Gln Ser 
    1010                 1015                 1020             


Ala Ser  Tyr Ile Pro Lys Ile  Thr His Pro Thr Asp  Thr Ser Asn 
    1025                 1030                 1035             


Phe Asp  Pro Val Asp Pro Asp  Lys Leu Trp Ser Asp  Asp Asn Glu 
    1040                 1045                 1050             


Glu Glu  Asn Val Asn Asp Thr  Leu Asn Gly Trp Tyr  Lys Asn Gly 
    1055                 1060                 1065             


Lys His  Pro Glu His Ala Phe  Tyr Glu Phe Thr Phe  Arg Arg Phe 
    1070                 1075                 1080             


Phe Asp  Asp Asn Gly Tyr Pro  Tyr Asn Tyr Pro Lys  Pro Ile Glu 
    1085                 1090                 1095             


Tyr Glu  Tyr Ile Asn Ser Gln  Gly Ser Glu Gln Gln  Ser Asp Glu 
    1100                 1105                 1110             


Asp Asp  Gln Asn Thr Gly Ser  Glu Ile Lys Asn Arg  Asp Leu Val 
    1115                 1120                 1125             


Tyr Val  
    1130 


<210>  2
<211>  690
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Arg Ser Glu Lys Pro Glu Gly Tyr Arg Gln Met Arg Pro Lys 
1               5                   10                  15      


Thr Phe Pro Ala Ser Asn Tyr Thr Val Ser Ser Arg Gln Met Leu Gln 
            20                  25                  30          


Glu Ile Arg Glu Ser Leu Arg Asn Leu Ser Lys Pro Ser Asp Ala Ala 
        35                  40                  45              


Lys Ala Glu His Asn Met Ser Lys Met Ser Thr Glu Asp Pro Arg Gln 
    50                  55                  60                  


Val Arg Asn Pro Pro Lys Phe Gly Thr His His Lys Ala Leu Gln Glu 
65                  70                  75                  80  


Ile Arg Asn Ser Leu Leu Pro Phe Ala Asn Glu Thr Asn Ser Ser Arg 
                85                  90                  95      


Ser Thr Ser Glu Val Asn Pro Gln Met Leu Gln Asp Leu Gln Ala Ala 
            100                 105                 110         


Gly Phe Asp Glu Asp Met Val Ile Gln Ala Leu Gln Lys Thr Asn Asn 
        115                 120                 125             


Arg Ser Ile Glu Ala Ala Ile Glu Phe Ile Ser Lys Met Ser Tyr Gln 
    130                 135                 140                 


Asp Pro Arg Arg Glu Gln Met Ala Ala Ala Ala Ala Arg Pro Ile Asn 
145                 150                 155                 160 


Ala Ser Met Lys Pro Gly Asn Val Gln Gln Ser Val Asn Arg Lys Gln 
                165                 170                 175     


Ser Trp Lys Gly Ser Lys Glu Ser Leu Val Pro Gln Arg His Gly Pro 
            180                 185                 190         


Pro Leu Gly Glu Ser Val Ala Tyr His Ser Glu Ser Pro Asn Ser Gln 
        195                 200                 205             


Thr Asp Val Gly Arg Pro Leu Ser Gly Ser Gly Ile Ser Ala Phe Val 
    210                 215                 220                 


Gln Ala His Pro Ser Asn Gly Gln Arg Val Asn Pro Pro Pro Pro Pro 
225                 230                 235                 240 


Gln Val Arg Ser Val Thr Pro Pro Pro Pro Pro Arg Gly Gln Thr Pro 
                245                 250                 255     


Pro Pro Arg Gly Thr Thr Pro Pro Pro Pro Ser Trp Glu Pro Asn Ser 
            260                 265                 270         


Gln Thr Lys Arg Tyr Ser Gly Asn Met Glu Tyr Val Ile Ser Arg Ile 
        275                 280                 285             


Ser Pro Val Pro Pro Gly Ala Trp Gln Glu Gly Tyr Pro Pro Pro Pro 
    290                 295                 300                 


Leu Asn Thr Ser Pro Met Asn Pro Pro Asn Gln Gly Gln Arg Gly Ile 
305                 310                 315                 320 


Ser Ser Val Pro Val Gly Arg Gln Pro Ile Ile Met Gln Ser Ser Ser 
                325                 330                 335     


Lys Phe Asn Phe Pro Ser Gly Arg Pro Gly Met Gln Asn Gly Thr Gly 
            340                 345                 350         


Gln Thr Asp Phe Met Ile His Gln Asn Val Val Pro Ala Gly Thr Val 
        355                 360                 365             


Asn Arg Gln Pro Pro Pro Pro Tyr Pro Leu Thr Ala Ala Asn Gly Gln 
    370                 375                 380                 


Ser Pro Ser Ala Leu Gln Thr Gly Gly Ser Ala Ala Pro Ser Ser Tyr 
385                 390                 395                 400 


Thr Asn Gly Ser Ile Pro Gln Ser Met Met Val Pro Asn Arg Asn Ser 
                405                 410                 415     


His Asn Met Glu Leu Tyr Asn Ile Ser Val Pro Gly Leu Gln Thr Asn 
            420                 425                 430         


Trp Pro Gln Ser Ser Ser Ala Pro Ala Gln Ser Ser Pro Ser Ser Gly 
        435                 440                 445             


His Glu Ile Pro Thr Trp Gln Pro Asn Ile Pro Val Arg Ser Asn Ser 
    450                 455                 460                 


Phe Asn Asn Pro Leu Gly Asn Arg Ala Ser His Ser Ala Asn Ser Gln 
465                 470                 475                 480 


Pro Ser Ala Thr Thr Val Thr Ala Ile Thr Pro Ala Pro Ile Gln Gln 
                485                 490                 495     


Pro Val Lys Ser Met Arg Val Leu Lys Pro Glu Leu Gln Thr Ala Leu 
            500                 505                 510         


Ala Pro Thr His Pro Ser Trp Ile Pro Gln Pro Ile Gln Thr Val Gln 
        515                 520                 525             


Pro Ser Pro Phe Pro Glu Gly Thr Ala Ser Asn Val Thr Val Met Pro 
    530                 535                 540                 


Pro Val Ala Glu Ala Pro Asn Tyr Gln Gly Pro Pro Pro Pro Tyr Pro 
545                 550                 555                 560 


Lys His Leu Leu His Gln Asn Pro Ser Val Pro Pro Tyr Glu Ser Ile 
                565                 570                 575     


Ser Lys Pro Ser Lys Glu Asp Gln Pro Ser Leu Pro Lys Glu Asp Glu 
            580                 585                 590         


Ser Glu Lys Ser Tyr Glu Asn Val Asp Ser Gly Asp Lys Glu Lys Lys 
        595                 600                 605             


Gln Ile Thr Thr Ser Pro Ile Thr Val Arg Lys Asn Lys Lys Asp Glu 
    610                 615                 620                 


Glu Arg Arg Glu Ser Arg Ile Gln Ser Tyr Ser Pro Gln Ala Phe Lys 
625                 630                 635                 640 


Phe Phe Met Glu Gln His Val Glu Asn Val Leu Lys Ser His Gln Gln 
                645                 650                 655     


Arg Leu His Arg Lys Lys Gln Leu Glu Asn Glu Met Met Arg Val Lys 
            660                 665                 670         


Pro Phe Lys Met Ser Ile Phe Ile Leu Asn His Leu Phe Ala Trp Cys 
        675                 680                 685             


Leu Phe 
    690 


<210>  3
<211>  1088
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Arg Pro Lys Thr Phe Pro Ala Thr Thr Tyr Ser Gly Asn Ser Arg 
1               5                   10                  15      


Gln Arg Leu Gln Glu Ile Arg Glu Gly Leu Lys Gln Pro Ser Lys Ser 
            20                  25                  30          


Ser Val Gln Gly Leu Pro Ala Gly Pro Asn Ser Asp Thr Ser Leu Asp 
        35                  40                  45              


Ala Lys Val Leu Gly Ser Lys Asp Ala Thr Arg Gln Gln Gln Gln Met 
    50                  55                  60                  


Arg Ala Thr Pro Lys Phe Gly Pro Tyr Gln Lys Ala Leu Arg Glu Ile 
65                  70                  75                  80  


Arg Tyr Ser Leu Leu Pro Phe Ala Asn Glu Ser Gly Thr Ser Ala Ala 
                85                  90                  95      


Ala Glu Val Asn Arg Gln Met Leu Gln Glu Leu Val Asn Ala Gly Cys 
            100                 105                 110         


Asp Gln Glu Met Ala Gly Arg Ala Leu Lys Gln Thr Gly Ser Arg Ser 
        115                 120                 125             


Ile Glu Ala Ala Leu Glu Tyr Ile Ser Lys Met Gly Tyr Leu Asp Pro 
    130                 135                 140                 


Arg Asn Glu Gln Ile Val Arg Val Ile Lys Gln Thr Ser Pro Gly Lys 
145                 150                 155                 160 


Gly Leu Met Pro Thr Pro Val Thr Arg Arg Pro Ser Phe Glu Gly Thr 
                165                 170                 175     


Gly Asp Ser Phe Ala Ser Tyr His Gln Leu Ser Gly Thr Pro Tyr Glu 
            180                 185                 190         


Gly Pro Ser Phe Gly Ala Asp Gly Pro Thr Ala Leu Glu Glu Met Pro 
        195                 200                 205             


Arg Pro Tyr Val Asp Tyr Leu Phe Pro Gly Val Gly Pro His Gly Pro 
    210                 215                 220                 


Gly His Gln His Gln His Pro Pro Lys Gly Tyr Gly Ala Ser Val Glu 
225                 230                 235                 240 


Ala Ala Gly Ala His Phe Pro Leu Gln Gly Ala His Tyr Gly Arg Pro 
                245                 250                 255     


His Leu Leu Val Pro Gly Glu Pro Leu Gly Tyr Gly Val Gln Arg Ser 
            260                 265                 270         


Pro Ser Phe Gln Ser Lys Thr Pro Pro Glu Thr Gly Gly Tyr Ala Ser 
        275                 280                 285             


Leu Pro Thr Lys Gly Gln Gly Gly Pro Pro Gly Ala Gly Leu Ala Phe 
    290                 295                 300                 


Pro Pro Pro Ala Ala Gly Leu Tyr Val Pro His Pro His His Lys Gln 
305                 310                 315                 320 


Ala Gly Pro Ala Ala His Gln Leu His Val Leu Gly Ser Arg Ser Gln 
                325                 330                 335     


Val Phe Ala Ser Asp Ser Pro Pro Gln Ser Leu Leu Thr Pro Ser Arg 
            340                 345                 350         


Asn Ser Leu Asn Val Asp Leu Tyr Glu Leu Gly Ser Thr Ser Val Gln 
        355                 360                 365             


Gln Trp Pro Ala Ala Thr Leu Ala Arg Arg Asp Ser Leu Gln Lys Pro 
    370                 375                 380                 


Gly Leu Glu Ala Pro Pro Arg Ala His Val Ala Phe Arg Pro Asp Cys 
385                 390                 395                 400 


Pro Val Pro Ser Arg Thr Asn Ser Phe Asn Ser His Gln Pro Arg Pro 
                405                 410                 415     


Gly Pro Pro Gly Lys Ala Glu Pro Ser Leu Pro Ala Pro Asn Thr Val 
            420                 425                 430         


Thr Ala Val Thr Ala Ala His Ile Leu His Pro Val Lys Ser Val Arg 
        435                 440                 445             


Val Leu Arg Pro Glu Pro Gln Thr Ala Val Gly Pro Ser His Pro Ala 
    450                 455                 460                 


Trp Val Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
465                 470                 475                 480 


Ala Glu Gly Leu Asp Ala Lys Glu Glu His Ala Leu Ala Leu Gly Gly 
                485                 490                 495     


Ala Gly Ala Phe Pro Leu Asp Val Glu Tyr Gly Gly Pro Asp Arg Arg 
            500                 505                 510         


Cys Pro Pro Pro Pro Tyr Pro Lys His Leu Leu Leu Arg Ser Lys Ser 
        515                 520                 525             


Glu Gln Tyr Asp Leu Asp Ser Leu Cys Ala Gly Met Glu Gln Ser Leu 
    530                 535                 540                 


Arg Ala Gly Pro Asn Glu Pro Glu Gly Gly Asp Lys Ser Arg Lys Ser 
545                 550                 555                 560 


Ala Lys Gly Asp Lys Gly Gly Lys Asp Lys Lys Gln Ile Gln Thr Ser 
                565                 570                 575     


Pro Val Pro Val Arg Lys Asn Ser Arg Asp Glu Glu Lys Arg Glu Ser 
            580                 585                 590         


Arg Ile Lys Ser Tyr Ser Pro Tyr Ala Phe Lys Phe Phe Met Glu Gln 
        595                 600                 605             


His Val Glu Asn Val Ile Lys Thr Tyr Gln Gln Lys Val Asn Arg Arg 
    610                 615                 620                 


Leu Gln Leu Glu Gln Glu Met Ala Lys Ala Gly Leu Cys Glu Ala Glu 
625                 630                 635                 640 


Gln Glu Gln Met Arg Lys Ile Leu Tyr Gln Lys Glu Ser Asn Tyr Asn 
                645                 650                 655     


Arg Leu Lys Arg Ala Lys Met Asp Lys Ser Met Phe Val Lys Ile Lys 
            660                 665                 670         


Thr Leu Gly Ile Gly Ala Phe Gly Glu Val Cys Leu Ala Cys Lys Val 
        675                 680                 685             


Asp Thr His Ala Leu Tyr Ala Met Lys Thr Leu Arg Lys Lys Asp Val 
    690                 695                 700                 


Leu Asn Arg Asn Gln Val Ala His Val Lys Ala Glu Arg Asp Ile Leu 
705                 710                 715                 720 


Ala Glu Ala Asp Asn Glu Trp Val Val Lys Leu Tyr Tyr Ser Phe Gln 
                725                 730                 735     


Asp Lys Asp Ser Leu Tyr Phe Val Met Asp Tyr Ile Pro Gly Gly Asp 
            740                 745                 750         


Met Met Ser Leu Leu Ile Arg Met Glu Val Phe Pro Glu His Leu Ala 
        755                 760                 765             


Arg Phe Tyr Ile Ala Glu Leu Thr Leu Ala Ile Glu Ser Val His Lys 
    770                 775                 780                 


Met Gly Phe Ile His Arg Asp Ile Lys Pro Asp Asn Ile Leu Ile Asp 
785                 790                 795                 800 


Leu Asp Gly His Ile Lys Leu Thr Asp Phe Gly Leu Cys Thr Gly Phe 
                805                 810                 815     


Arg Trp Thr His Asn Ser Lys Tyr Tyr Gln Lys Gly Ser His Val Arg 
            820                 825                 830         


Gln Asp Ser Met Glu Pro Ser Asp Leu Trp Asp Asp Val Ser Asn Cys 
        835                 840                 845             


Arg Cys Gly Asp Arg Leu Lys Thr Leu Glu Gln Arg Ala Arg Lys Gln 
    850                 855                 860                 


His Gln Arg Cys Leu Ala His Ser Leu Val Gly Thr Pro Asn Tyr Ile 
865                 870                 875                 880 


Ala Pro Glu Val Leu Leu Arg Lys Gly Tyr Thr Gln Leu Cys Asp Trp 
                885                 890                 895     


Trp Ser Val Gly Val Ile Leu Phe Glu Met Leu Val Gly Gln Pro Pro 
            900                 905                 910         


Phe Leu Ala Pro Thr Pro Thr Glu Thr Gln Leu Lys Val Ile Asn Trp 
        915                 920                 925             


Glu Asn Thr Leu His Ile Pro Ala Gln Val Lys Leu Ser Pro Glu Ala 
    930                 935                 940                 


Arg Asp Leu Ile Thr Lys Leu Cys Cys Ser Ala Asp His Arg Leu Gly 
945                 950                 955                 960 


Arg Asn Gly Ala Asp Asp Leu Lys Ala His Pro Phe Phe Ser Ala Ile 
                965                 970                 975     


Asp Phe Ser Ser Asp Ile Arg Lys Gln Pro Ala Pro Tyr Val Pro Thr 
            980                 985                 990         


Ile Ser His Pro Met Asp Thr Ser  Asn Phe Asp Pro Val  Asp Glu Glu 
        995                 1000                 1005             


Ser Pro  Trp Asn Asp Ala Ser  Glu Gly Ser Thr Lys  Ala Trp Asp 
    1010                 1015                 1020             


Thr Leu  Thr Ser Pro Asn Asn  Lys His Pro Glu His  Ala Phe Tyr 
    1025                 1030                 1035             


Glu Phe  Thr Phe Arg Arg Phe  Phe Asp Asp Asn Gly  Tyr Pro Phe 
    1040                 1045                 1050             


Arg Cys  Pro Lys Pro Ser Gly  Ala Glu Ala Ser Gln  Ala Glu Ser 
    1055                 1060                 1065             


Ser Asp  Leu Glu Ser Ser Asp  Leu Val Asp Gln Thr  Glu Gly Cys 
    1070                 1075                 1080             


Gln Pro  Val Tyr Val 
    1085             


<210>  4
<211>  5
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  n is a, c, g, or t

<400>  4
nggng                                                                    5


<210>  5
<211>  7
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  5
nnagaaw                                                                  7


<210>  6
<211>  5
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  6
nngrr                                                                    5


<210>  7
<211>  8
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  7
nnnngatt                                                                 8


<210>  8
<211>  7
<212>  PRT
<213>  Simian virus 40

<400>  8

Pro Lys Lys Lys Arg Lys Val 
1               5           


<210>  9
<211>  42
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  modified_base
<222>  (1)..(20)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(20)
<223>  n is a, c, g, or u

<400>  9
nnnnnnnnnn nnnnnnnnnn guuuuagagc uaugcuguuu ug                          42


<210>  10
<211>  86
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (80)..(86)
<223>  This region may encompass 1-7 nucleotides

<220>
<221>  misc_feature
<222>  (80)..(86)
<223>  This region may or may not be present

<400>  10
aacuuaccaa ggaacagcau agcaaguuaa aauaaggcua guccguuauc aacuugaaaa       60

aguggcaccg agucggugcu uuuuuu                                            86


<210>  11
<211>  74
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic oligonucleotide


<220>
<221>  misc_feature
<222>  (68)..(74)
<223>  This region may or may not be present

<220>
<221>  misc_feature
<222>  (68)..(74)
<223>  This region may encompass 1-7 nucleotides

<400>  11
aacagcauag caaguuaaaa uaaggcuagu ccguuaucaa cuugaaaaag uggcaccgag       60

ucggugcuuu uuuu                                                         74


<210>  12
<211>  102
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic polynucleotide


<220>
<221>  modified_base
<222>  (1)..(19)
<223>  a, c, u, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  n is a, c, g, or u

<220>
<221>  modified_base
<222>  (96)..(102)

<220>
<221>  modified_base
<222>  (96)..(102)

<400>  12
nnnnnnnnnn nnnnnnnnng uuuuagagcu agaaauagca aguuaaaaua aggcuagucc       60

guuaucaacu ugaaaaagug gcaccgaguc ggugcuuuuu uu                         102


<210>  13
<211>  21
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(18)

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (19)..(19)

<400>  13
nnnnnnnnnn nnnnnnnnng g                                                 21


<210>  14
<211>  19
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(16)

<220>
<221>  misc_feature
<222>  (1)..(17)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (17)..(17)

<400>  14
nnnnnnnnnn nnnnnnngg                                                    19


<210>  15
<211>  21
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(14)
<223>  a, c, t, or g

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  a, c, t, g, unknown or other

<400>  15
nnnnnnnnnn nnnnnnagaa w                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(14)
<223>  a, c, t, or g

<220>
<221>  misc_feature
<222>  (1)..(16)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (15)..(16)
<223>  a, c, t, g, unknown or other

<400>  16
nnnnnnnnnn nnnnnnagaa w                                                 21


<210>  17
<211>  23
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(18)
<223>  a, c, t, or g

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  a, c, t, g, unknown or other

<220>
<221>  modified_base
<222>  (22)..(22)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  n is a, c, g, or t

<400>  17
nnnnnnnnnn nnnnnnnnng gng                                               23


<210>  18
<211>  16
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(11)
<223>  a, c, t, or g

<220>
<221>  misc_feature
<222>  (1)..(12)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  a, c, t, g, unknown or other

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  18
nnnnnnnnnn nnggng                                                       16


<210>  19
<211>  8
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  19
nnnngatt                                                                 8


<210>  20
<211>  8
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(4)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  n is a, c, g, or t

<400>  20
nnnngctt                                                                 8


<210>  21
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  21
nngrrt                                                                   6


<210>  22
<211>  6
<212>  DNA
<213>  Unknown

<220>
<223>  Description of Unknown: Target sequence


<220>
<221>  modified_base
<222>  (1)..(2)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  n is a, c, g, or t

<400>  22
nngrrv                                                                   6


<210>  23
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  23
uggcugggca cgcguuuaau auaag                                             25


<210>  24
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  24
cugggcacgc guuuaauaua agugg                                             25


<210>  25
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  25
uuuaauauaa guggaggcgu cgcgc                                             25


<210>  26
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  26
aauauaagug gaggcgucgc gcugg                                             25


<210>  27
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  27
auauaagugg aggcgucgcg cuggc                                             25


<210>  28
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  28
gggcauuccu gaagcugaca gcauu                                             25


<210>  29
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  29
ggcauuccug aagcugacag cauuc                                             25


<210>  30
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  30
auucgggccg agaugucucg cuccg                                             25


<210>  31
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  31
cugugcucgc gcuacucucu cuuuc                                             25


<210>  32
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  32
cucgcgcuac ucucucuuuc uggcc                                             25


<210>  33
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  33
gcgcuacucu cucuuucugg ccugg                                             25


<210>  34
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  34
gcgcuacucu cucuuucugg ccugg                                             25


<210>  35
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  35
ucucggcccg aaugcuguca gcuuc                                             25


<210>  36
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  36
gcuaaggcca cggagcgaga caucu                                             25


<210>  37
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  37
aguagcgcga gcacagcuaa ggcca                                             25


<210>  38
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  38
agagagagua gcgcgagcac agcua                                             25


<210>  39
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  39
gagagacuca cgcuggauag ccucc                                             25


<210>  40
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  40
gcgggagggu aggagagacu cacgc                                             25


<210>  41
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  41
uauuccucag guacuccaaa gauuc                                             25


<210>  42
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  42
uuuacucacg ucauccagca gagaa                                             25


<210>  43
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  43
caaauuuccu gaauugcuau guguc                                             25


<210>  44
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  44
aaauuuccug aauugcuaug ugucu                                             25


<210>  45
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  45
acauugaagu ugacuuacug aagaa                                             25


<210>  46
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  46
aagaauggag agagaauuga aaaag                                             25


<210>  47
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  47
gagcauucag acuugucuuu cagca                                             25


<210>  48
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  48
uucagacuug ucuuucagca aggac                                             25


<210>  49
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  49
uuugucacag cccaagauag uuaag                                             25


<210>  50
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  50
uugucacagc ccaagauagu uaagu                                             25


<210>  51
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  51
ugucacagcc caagauaguu aagug                                             25


<210>  52
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  52
aucuuuggag uaccugagga auauc                                             25


<210>  53
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  53
aaucuuugga guaccugagg aauau                                             25


<210>  54
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  54
uaaaccugaa ucuuuggagu accug                                             25


<210>  55
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  55
gaugacguga guaaaccuga aucuu                                             25


<210>  56
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  56
ggaaauuuga cuuuccauuc ucugc                                             25


<210>  57
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  57
augaaaccca gacacauagc aauuc                                             25


<210>  58
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  58
ucaguaaguc aacuucaaug ucgga                                             25


<210>  59
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  59
uucuucagua agucaacuuc aaugu                                             25


<210>  60
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  60
caggcauacu caucuuuuuc agugg                                             25


<210>  61
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  61
gcaggcauac ucaucuuuuu cagug                                             25


<210>  62
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  62
ggcaggcaua cucaucuuuu ucagu                                             25


<210>  63
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  63
cggcaggcau acucaucuuu uucag                                             25


<210>  64
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  64
gacaaaguca caugguucac acggc                                             25


<210>  65
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  65
cugugacaaa gucacauggu ucaca                                             25


<210>  66
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  66
uaucuugggc ugugacaaag ucaca                                             25


<210>  67
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  67
aagacuuacc ccacuuaacu aucuu                                             25


<210>  68
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  68
uaagacuuac cccacuuaac uaucu                                             25


<210>  69
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  69
agaucgagac auguaagcag cauca                                             25


<210>  70
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  70
ucgagacaug uaagcagcau caugg                                             25


<210>  71
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  71
augucucgau cuaugaaaaa gacag                                             25


<210>  72
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  72
uuuucagguu ugaagaugcc gcauu                                             25


<210>  73
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  73
agguuugaag augccgcauu uggau                                             25


<210>  74
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  74
cacuuacacu uuaugcacaa aaugu                                             25


<210>  75
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  75
acuuacacuu uaugcacaaa augua                                             25


<210>  76
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  76
auguaggguu auaauaaugu uaaca                                             25


<210>  77
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  77
gucuccaugu uugauguauc ugagc                                             25


<210>  78
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  78
gauguaucug agcagguugc uccac                                             25


<210>  79
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  79
agcagguugc uccacaggua gcucu                                             25


<210>  80
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  80
agguugcucc acagguagcu cuagg                                             25


<210>  81
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  81
gguugcucca cagguagcuc uagga                                             25


<210>  82
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  82
gcuccacagg uagcucuagg agggc                                             25


<210>  83
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  83
agcucuagga gggcuggcaa cuuag                                             25


<210>  84
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  84
ucuaggaggg cuggcaacuu agagg                                             25


<210>  85
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  85
cuaggagggc uggcaacuua gaggu                                             25


<210>  86
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  86
uaggagggcu ggcaacuuag aggug                                             25


<210>  87
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  87
auucucuuau ccaacaucaa caucu                                             25


<210>  88
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  88
caauuuacau acucugcuua gaauu                                             25


<210>  89
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  89
aauuuacaua cucugcuuag aauuu                                             25


<210>  90
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  90
auuuacauac ucugcuuaga auuug                                             25


<210>  91
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  91
uuuacauacu cugcuuagaa uuugg                                             25


<210>  92
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  92
gggaaaauuu agaaauauaa uugac                                             25


<210>  93
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  93
uuagaaauau aauugacagg auuau                                             25


<210>  94
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  94
uacuucuuau acauuugaua aagua                                             25


<210>  95
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  95
cuuauacauu ugauaaagua aggca                                             25


<210>  96
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  96
cauuugauaa aguaaggcau gguug                                             25


<210>  97
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  97
aaguaaggca ugguuguggu uaauc                                             25


<210>  98
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  98
cuucaaaccu gaaaagaaaa gaaaa                                             25


<210>  99
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  99
auuuggaauu cauccaaucc aaaug                                             25


<210>  100
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  100
uauuaaaaag caagcaagca gaauu                                             25


<210>  101
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  101
gcaaccugcu cagauacauc aaaca                                             25


<210>  102
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  102
uugccagccc uccuagagcu accug                                             25


<210>  103
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  103
ucaaaucuga ccaagauguu gaugu                                             25


<210>  104
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  104
caaauucuaa gcagaguaug uaaau                                             25


<210>  105
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  105
caaguuuuau gauuuauuua acuug                                             25


<210>  106
<211>  1386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  106

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Glu Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  His His His 
    1370                 1375                 1380             


His His  His 
    1385     


<210>  107
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic peptide

<400>  107

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  108
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  108
gaguagcgcg agcacagcua                                                   20


<210>  109
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  109
cgugaguaaa ccugaaucuu                                                   20


<210>  110
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  110
aagucaacuu caaugucgga                                                   20


<210>  111
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  111
caguaaguca acuucaaugu                                                   20


<210>  112
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  112
cugaaucuuu ggaguaccug                                                   20


<210>  113
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  113
ggccgagaug ucucgcuccg                                                   20


<210>  114
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  114
cucgcgcuac ucucucuuuc                                                   20


<210>  115
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  115
acucacgcug gauagccucc                                                   20


<210>  116
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  116
ucacgucauc cagcagagaa                                                   20


<210>  117
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  117
agucacaugg uucacacggc                                                   20


<210>  118
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  118
ccaccucuug auggggcuag                                                   20


<210>  119
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  119
gcuacucucu cuuucuggcc                                                   20


<210>  120
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic nucleotide

<400>  120
gaguagcgcg agcacagcua guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  121
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 6xHis tag

<400>  121

His His His His His His 
1               5       


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Description of Artificial Sequence: Synthetic 8xHis tag

<400>  122

His His His His His His His His 
1               5               


<210>  123
<211>  1368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  123

Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser Val 
1               5                   10                  15      


Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe 
            20                  25                  30          


Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu Ile 
        35                  40                  45              


Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu 
    50                  55                  60                  


Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys 
65                  70                  75                  80  


Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp Ser 
                85                  90                  95      


Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys Lys 
            100                 105                 110         


His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala Tyr 
        115                 120                 125             


His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val Asp 
    130                 135                 140                 


Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala His 
145                 150                 155                 160 


Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn Pro 
                165                 170                 175     


Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr 
            180                 185                 190         


Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp Ala 
        195                 200                 205             


Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn 
    210                 215                 220                 


Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn 
225                 230                 235                 240 


Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe 
                245                 250                 255     


Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp 
            260                 265                 270         


Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp 
        275                 280                 285             


Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp 
    290                 295                 300                 


Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser 
305                 310                 315                 320 


Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu Lys 
                325                 330                 335     


Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe 
            340                 345                 350         


Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser 
        355                 360                 365             


Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met Asp 
    370                 375                 380                 


Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu Arg 
385                 390                 395                 400 


Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His Leu 
                405                 410                 415     


Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe 
            420                 425                 430         


Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile 
        435                 440                 445             


Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp 
    450                 455                 460                 


Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu 
465                 470                 475                 480 


Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met Thr 
                485                 490                 495     


Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His Ser 
            500                 505                 510         


Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val Lys 
        515                 520                 525             


Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln 
    530                 535                 540                 


Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val Thr 
545                 550                 555                 560 


Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp 
                565                 570                 575     


Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu Gly 
            580                 585                 590         


Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp 
        595                 600                 605             


Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu Thr 
    610                 615                 620                 


Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala 
625                 630                 635                 640 


His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg Tyr 
                645                 650                 655     


Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp 
            660                 665                 670         


Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe 
        675                 680                 685             


Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr Phe 
    690                 695                 700                 


Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser Leu 
705                 710                 715                 720 


His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly 
                725                 730                 735     


Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met Gly 
            740                 745                 750         


Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn Gln 
        755                 760                 765             


Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg Ile 
    770                 775                 780                 


Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His Pro 
785                 790                 795                 800 


Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu 
                805                 810                 815     


Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg 
            820                 825                 830         


Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu Lys 
        835                 840                 845             


Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn Arg 
    850                 855                 860                 


Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met Lys 
865                 870                 875                 880 


Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys 
                885                 890                 895     


Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp 
            900                 905                 910         


Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile Thr 
        915                 920                 925             


Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp 
    930                 935                 940                 


Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys Ser 
945                 950                 955                 960 


Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg 
                965                 970                 975     


Glu Ile Asn Asn Tyr His His Ala His Asp Ala Tyr Leu Asn Ala Val 
            980                 985                 990         


Val Gly Thr Ala Leu Ile Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe 
        995                 1000                 1005             


Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala 
    1010                 1015                 1020             


Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe 
    1025                 1030                 1035             


Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala 
    1040                 1045                 1050             


Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu 
    1055                 1060                 1065             


Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val 
    1070                 1075                 1080             


Arg Lys  Val Leu Ser Met Pro  Gln Val Asn Ile Val  Lys Lys Thr 
    1085                 1090                 1095             


Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys 
    1100                 1105                 1110             


Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val 
    1130                 1135                 1140             


Leu Val  Val Ala Lys Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys 
    1145                 1150                 1155             


Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser 
    1160                 1165                 1170             


Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys 
    1175                 1180                 1185             


Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu 
    1190                 1195                 1200             


Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly 
    1205                 1210                 1215             


Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val 
    1220                 1225                 1230             


Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser 
    1235                 1240                 1245             


Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe Val Glu  Gln His Lys 
    1250                 1255                 1260             


His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys 
    1265                 1270                 1275             


Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala 
    1280                 1285                 1290             


Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn 
    1295                 1300                 1305             


Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala 
    1310                 1315                 1320             


Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser 
    1325                 1330                 1335             


Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr 
    1340                 1345                 1350             


Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp 
    1355                 1360                 1365             


<210>  124
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  124

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Leu Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Glu Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  125
<211>  1399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  125

Met Gly Ser Ser His His His His His His His His Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
            20                  25                  30          


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        35                  40                  45              


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    50                  55                  60                  


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
65                  70                  75                  80  


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                85                  90                  95      


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            100                 105                 110         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        115                 120                 125             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    130                 135                 140                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
145                 150                 155                 160 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                165                 170                 175     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            180                 185                 190         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        195                 200                 205             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    210                 215                 220                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                245                 250                 255     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            260                 265                 270         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        275                 280                 285             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    290                 295                 300                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
305                 310                 315                 320 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                325                 330                 335     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            340                 345                 350         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    370                 375                 380                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
385                 390                 395                 400 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                405                 410                 415     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            420                 425                 430         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        435                 440                 445             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
465                 470                 475                 480 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                485                 490                 495     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            500                 505                 510         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        515                 520                 525             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    530                 535                 540                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
545                 550                 555                 560 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                565                 570                 575     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            580                 585                 590         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        595                 600                 605             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    610                 615                 620                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
625                 630                 635                 640 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                645                 650                 655     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            660                 665                 670         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    690                 695                 700                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                725                 730                 735     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            740                 745                 750         


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
        755                 760                 765             


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
    770                 775                 780                 


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
785                 790                 795                 800 


Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu 
                805                 810                 815     


Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu 
        835                 840                 845             


Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln 
    850                 855                 860                 


Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 
865                 870                 875                 880 


Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
                885                 890                 895     


Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile 
            900                 905                 910         


Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
        915                 920                 925             


Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr 
    930                 935                 940                 


Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn 
945                 950                 955                 960 


Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile 
                965                 970                 975     


Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe 
            980                 985                 990         


Tyr Lys Val Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
        995                 1000                 1005             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1010                 1015                 1020             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1025                 1030                 1035             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1040                 1045                 1050             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1055                 1060                 1065             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1070                 1075                 1080             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1085                 1090                 1095             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1100                 1105                 1110             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1115                 1120                 1125             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1130                 1135                 1140             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1145                 1150                 1155             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1160                 1165                 1170             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1175                 1180                 1185             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1190                 1195                 1200             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1205                 1210                 1215             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1220                 1225                 1230             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1235                 1240                 1245             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1250                 1255                 1260             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1265                 1270                 1275             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1280                 1285                 1290             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1295                 1300                 1305             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1310                 1315                 1320             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1325                 1330                 1335             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1340                 1345                 1350             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1370                 1375                 1380             


Gln Leu  Gly Gly Asp Gly Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1385                 1390                 1395             


Val 
    


<210>  126
<211>  2792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  126

Met Ala His His His His His His Gly Gly Ser Pro Lys Lys Lys Arg 
1               5                   10                  15      


Lys Val Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly Thr Asn Ser 
            20                  25                  30          


Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro Ser Lys Lys 
        35                  40                  45              


Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys Lys Asn Leu 
    50                  55                  60                  


Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu Ala Thr Arg 
65                  70                  75                  80  


Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys Asn Arg Ile 
                85                  90                  95      


Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys Val Asp Asp 
            100                 105                 110         


Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu Glu Asp Lys 
        115                 120                 125             


Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp Glu Val Ala 
    130                 135                 140                 


Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys Lys Leu Val 
145                 150                 155                 160 


Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu Ala Leu Ala 
                165                 170                 175     


His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly Asp Leu Asn 
            180                 185                 190         


Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu Val Gln Thr 
        195                 200                 205             


Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser Gly Val Asp 
    210                 215                 220                 


Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg Arg Leu Glu 
225                 230                 235                 240 


Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly Leu Phe Gly 
                245                 250                 255     


Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe Lys Ser Asn 
            260                 265                 270         


Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys Asp Thr Tyr 
        275                 280                 285             


Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp Gln Tyr Ala 
    290                 295                 300                 


Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile Leu Leu Ser 
305                 310                 315                 320 


Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro Leu Ser Ala 
                325                 330                 335     


Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu Thr Leu Leu 
            340                 345                 350         


Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys Glu Ile Phe 
        355                 360                 365             


Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp Gly Gly Ala 
    370                 375                 380                 


Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu Glu Lys Met 
385                 390                 395                 400 


Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu Asp Leu Leu 
                405                 410                 415     


Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His Gln Ile His 
            420                 425                 430         


Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp Phe Tyr Pro 
        435                 440                 445             


Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu Thr Phe Arg 
    450                 455                 460                 


Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser Arg Phe Ala 
465                 470                 475                 480 


Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp Asn Phe Glu 
                485                 490                 495     


Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile Glu Arg Met 
            500                 505                 510         


Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu Pro Lys His 
        515                 520                 525             


Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu Thr Lys Val 
    530                 535                 540                 


Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu Ser Gly Glu 
545                 550                 555                 560 


Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn Arg Lys Val 
                565                 570                 575     


Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile Glu Cys Phe 
            580                 585                 590         


Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn Ala Ser Leu 
        595                 600                 605             


Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys Asp Phe Leu 
    610                 615                 620                 


Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val Leu Thr Leu 
625                 630                 635                 640 


Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu Lys Thr Tyr 
                645                 650                 655     


Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys Arg Arg Arg 
            660                 665                 670         


Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn Gly Ile Arg 
        675                 680                 685             


Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys Ser Asp Gly 
    690                 695                 700                 


Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp Ser Leu Thr 
705                 710                 715                 720 


Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln Gly Asp Ser 
                725                 730                 735     


Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala Ile Lys Lys 
            740                 745                 750         


Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val Lys Val Met 
        755                 760                 765             


Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala Arg Glu Asn 
    770                 775                 780                 


Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg Met Lys Arg 
785                 790                 795                 800 


Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu Lys Glu His 
                805                 810                 815     


Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr 
            820                 825                 830         


Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu Asp Ile Asn 
        835                 840                 845             


Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln Ser Phe Leu 
    850                 855                 860                 


Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser Asp Lys Asn 
865                 870                 875                 880 


Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val Lys Lys Met 
                885                 890                 895     


Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile Thr Gln Arg 
            900                 905                 910         


Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu Ser Glu Leu 
        915                 920                 925             


Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr Arg Gln Ile 
    930                 935                 940                 


Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn Thr Lys Tyr 
945                 950                 955                 960 


Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile Thr Leu Lys 
                965                 970                 975     


Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe Tyr Lys Val 
            980                 985                 990         


Arg Glu Ile Asn Asn Tyr His His  Ala His Asp Ala Tyr  Leu Asn Ala 
        995                 1000                 1005             


Val Val  Gly Thr Ala Leu Ile  Lys Lys Tyr Pro Lys  Leu Glu Ser 
    1010                 1015                 1020             


Glu Phe  Val Tyr Gly Asp Tyr  Lys Val Tyr Asp Val  Arg Lys Met 
    1025                 1030                 1035             


Ile Ala  Lys Ser Glu Gln Glu  Ile Gly Lys Ala Thr  Ala Lys Tyr 
    1040                 1045                 1050             


Phe Phe  Tyr Ser Asn Ile Met  Asn Phe Phe Lys Thr  Glu Ile Thr 
    1055                 1060                 1065             


Leu Ala  Asn Gly Glu Ile Arg  Lys Arg Pro Leu Ile  Glu Thr Asn 
    1070                 1075                 1080             


Gly Glu  Thr Gly Glu Ile Val  Trp Asp Lys Gly Arg  Asp Phe Ala 
    1085                 1090                 1095             


Thr Val  Arg Lys Val Leu Ser  Met Pro Gln Val Asn  Ile Val Lys 
    1100                 1105                 1110             


Lys Thr  Glu Val Gln Thr Gly  Gly Phe Ser Lys Glu  Ser Ile Leu 
    1115                 1120                 1125             


Pro Lys  Arg Asn Ser Asp Lys  Leu Ile Ala Arg Lys  Lys Asp Trp 
    1130                 1135                 1140             


Asp Pro  Lys Lys Tyr Gly Gly  Phe Asp Ser Pro Thr  Val Ala Tyr 
    1145                 1150                 1155             


Ser Val  Leu Val Val Ala Lys  Val Glu Lys Gly Lys  Ser Lys Lys 
    1160                 1165                 1170             


Leu Lys  Ser Val Lys Glu Leu  Leu Gly Ile Thr Ile  Met Glu Arg 
    1175                 1180                 1185             


Ser Ser  Phe Glu Lys Asn Pro  Ile Asp Phe Leu Glu  Ala Lys Gly 
    1190                 1195                 1200             


Tyr Lys  Glu Val Lys Lys Asp  Leu Ile Ile Lys Leu  Pro Lys Tyr 
    1205                 1210                 1215             


Ser Leu  Phe Glu Leu Glu Asn  Gly Arg Lys Arg Met  Leu Ala Ser 
    1220                 1225                 1230             


Ala Gly  Glu Leu Gln Lys Gly  Asn Glu Leu Ala Leu  Pro Ser Lys 
    1235                 1240                 1245             


Tyr Val  Asn Phe Leu Tyr Leu  Ala Ser His Tyr Glu  Lys Leu Lys 
    1250                 1255                 1260             


Gly Ser  Pro Glu Asp Asn Glu  Gln Lys Gln Leu Phe  Val Glu Gln 
    1265                 1270                 1275             


His Lys  His Tyr Leu Asp Glu  Ile Ile Glu Gln Ile  Ser Glu Phe 
    1280                 1285                 1290             


Ser Lys  Arg Val Ile Leu Ala  Asp Ala Asn Leu Asp  Lys Val Leu 
    1295                 1300                 1305             


Ser Ala  Tyr Asn Lys His Arg  Asp Lys Pro Ile Arg  Glu Gln Ala 
    1310                 1315                 1320             


Glu Asn  Ile Ile His Leu Phe  Thr Leu Thr Asn Leu  Gly Ala Pro 
    1325                 1330                 1335             


Ala Ala  Phe Lys Tyr Phe Asp  Thr Thr Ile Asp Arg  Lys Arg Tyr 
    1340                 1345                 1350             


Thr Ser  Thr Lys Glu Val Leu  Asp Ala Thr Leu Ile  His Gln Ser 
    1355                 1360                 1365             


Ile Thr  Gly Leu Tyr Glu Thr  Arg Ile Asp Leu Ser  Gln Leu Gly 
    1370                 1375                 1380             


Gly Asp  Ser Arg Ala Asp Pro  Lys Lys Lys Arg Lys  Val Met Ala 
    1385                 1390                 1395             


His His  His His His His Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1400                 1405                 1410             


Val Asp  Lys Lys Tyr Ser Ile  Gly Leu Asp Ile Gly  Thr Asn Ser 
    1415                 1420                 1425             


Val Gly  Trp Ala Val Ile Thr  Asp Glu Tyr Lys Val  Pro Ser Lys 
    1430                 1435                 1440             


Lys Phe  Lys Val Leu Gly Asn  Thr Asp Arg His Ser  Ile Lys Lys 
    1445                 1450                 1455             


Asn Leu  Ile Gly Ala Leu Leu  Phe Asp Ser Gly Glu  Thr Ala Glu 
    1460                 1465                 1470             


Ala Thr  Arg Leu Lys Arg Thr  Ala Arg Arg Arg Tyr  Thr Arg Arg 
    1475                 1480                 1485             


Lys Asn  Arg Ile Cys Tyr Leu  Gln Glu Ile Phe Ser  Asn Glu Met 
    1490                 1495                 1500             


Ala Lys  Val Asp Asp Ser Phe  Phe His Arg Leu Glu  Glu Ser Phe 
    1505                 1510                 1515             


Leu Val  Glu Glu Asp Lys Lys  His Glu Arg His Pro  Ile Phe Gly 
    1520                 1525                 1530             


Asn Ile  Val Asp Glu Val Ala  Tyr His Glu Lys Tyr  Pro Thr Ile 
    1535                 1540                 1545             


Tyr His  Leu Arg Lys Lys Leu  Val Asp Ser Thr Asp  Lys Ala Asp 
    1550                 1555                 1560             


Leu Arg  Leu Ile Tyr Leu Ala  Leu Ala His Met Ile  Lys Phe Arg 
    1565                 1570                 1575             


Gly His  Phe Leu Ile Glu Gly  Asp Leu Asn Pro Asp  Asn Ser Asp 
    1580                 1585                 1590             


Val Asp  Lys Leu Phe Ile Gln  Leu Val Gln Thr Tyr  Asn Gln Leu 
    1595                 1600                 1605             


Phe Glu  Glu Asn Pro Ile Asn  Ala Ser Gly Val Asp  Ala Lys Ala 
    1610                 1615                 1620             


Ile Leu  Ser Ala Arg Leu Ser  Lys Ser Arg Arg Leu  Glu Asn Leu 
    1625                 1630                 1635             


Ile Ala  Gln Leu Pro Gly Glu  Lys Lys Asn Gly Leu  Phe Gly Asn 
    1640                 1645                 1650             


Leu Ile  Ala Leu Ser Leu Gly  Leu Thr Pro Asn Phe  Lys Ser Asn 
    1655                 1660                 1665             


Phe Asp  Leu Ala Glu Asp Ala  Lys Leu Gln Leu Ser  Lys Asp Thr 
    1670                 1675                 1680             


Tyr Asp  Asp Asp Leu Asp Asn  Leu Leu Ala Gln Ile  Gly Asp Gln 
    1685                 1690                 1695             


Tyr Ala  Asp Leu Phe Leu Ala  Ala Lys Asn Leu Ser  Asp Ala Ile 
    1700                 1705                 1710             


Leu Leu  Ser Asp Ile Leu Arg  Val Asn Thr Glu Ile  Thr Lys Ala 
    1715                 1720                 1725             


Pro Leu  Ser Ala Ser Met Ile  Lys Arg Tyr Asp Glu  His His Gln 
    1730                 1735                 1740             


Asp Leu  Thr Leu Leu Lys Ala  Leu Val Arg Gln Gln  Leu Pro Glu 
    1745                 1750                 1755             


Lys Tyr  Lys Glu Ile Phe Phe  Asp Gln Ser Lys Asn  Gly Tyr Ala 
    1760                 1765                 1770             


Gly Tyr  Ile Asp Gly Gly Ala  Ser Gln Glu Glu Phe  Tyr Lys Phe 
    1775                 1780                 1785             


Ile Lys  Pro Ile Leu Glu Lys  Met Asp Gly Thr Glu  Glu Leu Leu 
    1790                 1795                 1800             


Val Lys  Leu Asn Arg Glu Asp  Leu Leu Arg Lys Gln  Arg Thr Phe 
    1805                 1810                 1815             


Asp Asn  Gly Ser Ile Pro His  Gln Ile His Leu Gly  Glu Leu His 
    1820                 1825                 1830             


Ala Ile  Leu Arg Arg Gln Glu  Asp Phe Tyr Pro Phe  Leu Lys Asp 
    1835                 1840                 1845             


Asn Arg  Glu Lys Ile Glu Lys  Ile Leu Thr Phe Arg  Ile Pro Tyr 
    1850                 1855                 1860             


Tyr Val  Gly Pro Leu Ala Arg  Gly Asn Ser Arg Phe  Ala Trp Met 
    1865                 1870                 1875             


Thr Arg  Lys Ser Glu Glu Thr  Ile Thr Pro Trp Asn  Phe Glu Glu 
    1880                 1885                 1890             


Val Val  Asp Lys Gly Ala Ser  Ala Gln Ser Phe Ile  Glu Arg Met 
    1895                 1900                 1905             


Thr Asn  Phe Asp Lys Asn Leu  Pro Asn Glu Lys Val  Leu Pro Lys 
    1910                 1915                 1920             


His Ser  Leu Leu Tyr Glu Tyr  Phe Thr Val Tyr Asn  Glu Leu Thr 
    1925                 1930                 1935             


Lys Val  Lys Tyr Val Thr Glu  Gly Met Arg Lys Pro  Ala Phe Leu 
    1940                 1945                 1950             


Ser Gly  Glu Gln Lys Lys Ala  Ile Val Asp Leu Leu  Phe Lys Thr 
    1955                 1960                 1965             


Asn Arg  Lys Val Thr Val Lys  Gln Leu Lys Glu Asp  Tyr Phe Lys 
    1970                 1975                 1980             


Lys Ile  Glu Cys Phe Asp Ser  Val Glu Ile Ser Gly  Val Glu Asp 
    1985                 1990                 1995             


Arg Phe  Asn Ala Ser Leu Gly  Thr Tyr His Asp Leu  Leu Lys Ile 
    2000                 2005                 2010             


Ile Lys  Asp Lys Asp Phe Leu  Asp Asn Glu Glu Asn  Glu Asp Ile 
    2015                 2020                 2025             


Leu Glu  Asp Ile Val Leu Thr  Leu Thr Leu Phe Glu  Asp Arg Glu 
    2030                 2035                 2040             


Met Ile  Glu Glu Arg Leu Lys  Thr Tyr Ala His Leu  Phe Asp Asp 
    2045                 2050                 2055             


Lys Val  Met Lys Gln Leu Lys  Arg Arg Arg Tyr Thr  Gly Trp Gly 
    2060                 2065                 2070             


Arg Leu  Ser Arg Lys Leu Ile  Asn Gly Ile Arg Asp  Lys Gln Ser 
    2075                 2080                 2085             


Gly Lys  Thr Ile Leu Asp Phe  Leu Lys Ser Asp Gly  Phe Ala Asn 
    2090                 2095                 2100             


Arg Asn  Phe Met Gln Leu Ile  His Asp Asp Ser Leu  Thr Phe Lys 
    2105                 2110                 2115             


Glu Asp  Ile Gln Lys Ala Gln  Val Ser Gly Gln Gly  Asp Ser Leu 
    2120                 2125                 2130             


His Glu  His Ile Ala Asn Leu  Ala Gly Ser Pro Ala  Ile Lys Lys 
    2135                 2140                 2145             


Gly Ile  Leu Gln Thr Val Lys  Val Val Asp Glu Leu  Val Lys Val 
    2150                 2155                 2160             


Met Gly  Arg His Lys Pro Glu  Asn Ile Val Ile Glu  Met Ala Arg 
    2165                 2170                 2175             


Glu Asn  Gln Thr Thr Gln Lys  Gly Gln Lys Asn Ser  Arg Glu Arg 
    2180                 2185                 2190             


Met Lys  Arg Ile Glu Glu Gly  Ile Lys Glu Leu Gly  Ser Gln Ile 
    2195                 2200                 2205             


Leu Lys  Glu His Pro Val Glu  Asn Thr Gln Leu Gln  Asn Glu Lys 
    2210                 2215                 2220             


Leu Tyr  Leu Tyr Tyr Leu Gln  Asn Gly Arg Asp Met  Tyr Val Asp 
    2225                 2230                 2235             


Gln Glu  Leu Asp Ile Asn Arg  Leu Ser Asp Tyr Asp  Val Asp His 
    2240                 2245                 2250             


Ile Val  Pro Gln Ser Phe Leu  Lys Asp Asp Ser Ile  Asp Asn Lys 
    2255                 2260                 2265             


Val Leu  Thr Arg Ser Asp Lys  Asn Arg Gly Lys Ser  Asp Asn Val 
    2270                 2275                 2280             


Pro Ser  Glu Glu Val Val Lys  Lys Met Lys Asn Tyr  Trp Arg Gln 
    2285                 2290                 2295             


Leu Leu  Asn Ala Lys Leu Ile  Thr Gln Arg Lys Phe  Asp Asn Leu 
    2300                 2305                 2310             


Thr Lys  Ala Glu Arg Gly Gly  Leu Ser Glu Leu Asp  Lys Ala Gly 
    2315                 2320                 2325             


Phe Ile  Lys Arg Gln Leu Val  Glu Thr Arg Gln Ile  Thr Lys His 
    2330                 2335                 2340             


Val Ala  Gln Ile Leu Asp Ser  Arg Met Asn Thr Lys  Tyr Asp Glu 
    2345                 2350                 2355             


Asn Asp  Lys Leu Ile Arg Glu  Val Lys Val Ile Thr  Leu Lys Ser 
    2360                 2365                 2370             


Lys Leu  Val Ser Asp Phe Arg  Lys Asp Phe Gln Phe  Tyr Lys Val 
    2375                 2380                 2385             


Arg Glu  Ile Asn Asn Tyr His  His Ala His Asp Ala  Tyr Leu Asn 
    2390                 2395                 2400             


Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys Tyr Pro  Lys Leu Glu 
    2405                 2410                 2415             


Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val Tyr Asp  Val Arg Lys 
    2420                 2425                 2430             


Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly Lys Ala  Thr Ala Lys 
    2435                 2440                 2445             


Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe Phe Lys  Thr Glu Ile 
    2450                 2455                 2460             


Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg Pro Leu  Ile Glu Thr 
    2465                 2470                 2475             


Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp Lys Gly  Arg Asp Phe 
    2480                 2485                 2490             


Ala Thr  Val Arg Lys Val Leu  Ser Met Pro Gln Val  Asn Ile Val 
    2495                 2500                 2505             


Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe Ser Lys  Glu Ser Ile 
    2510                 2515                 2520             


Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile Ala Arg  Lys Lys Asp 
    2525                 2530                 2535             


Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp Ser Pro  Thr Val Ala 
    2540                 2545                 2550             


Tyr Ser  Val Leu Val Val Ala  Lys Val Glu Lys Gly  Lys Ser Lys 
    2555                 2560                 2565             


Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly Ile Thr  Ile Met Glu 
    2570                 2575                 2580             


Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp Phe Leu  Glu Ala Lys 
    2585                 2590                 2595             


Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile Ile Lys  Leu Pro Lys 
    2600                 2605                 2610             


Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg Lys Arg  Met Leu Ala 
    2615                 2620                 2625             


Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu Leu Ala  Leu Pro Ser 
    2630                 2635                 2640             


Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser His Tyr  Glu Lys Leu 
    2645                 2650                 2655             


Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys Gln Leu  Phe Val Glu 
    2660                 2665                 2670             


Gln His  Lys His Tyr Leu Asp  Glu Ile Ile Glu Gln  Ile Ser Glu 
    2675                 2680                 2685             


Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala Asn Leu  Asp Lys Val 
    2690                 2695                 2700             


Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys Pro Ile  Arg Glu Gln 
    2705                 2710                 2715             


Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu Thr Asn  Leu Gly Ala 
    2720                 2725                 2730             


Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr Ile Asp  Arg Lys Arg 
    2735                 2740                 2745             


Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala Thr Leu  Ile His Gln 
    2750                 2755                 2760             


Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile Asp Leu  Ser Gln Leu 
    2765                 2770                 2775             


Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys Lys Arg  Lys Val 
    2780                 2785                 2790         


<210>  127
<211>  1386
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  127

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  His His His 
    1370                 1375                 1380             


His His  His 
    1385     


<210>  128
<211>  1389
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  128

Met Ala His His His His His His Gly Gly Ser Asp Lys Lys Tyr Ser 
1               5                   10                  15      


Ile Gly Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr 
            20                  25                  30          


Asp Glu Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr 
        35                  40                  45              


Asp Arg His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp 
    50                  55                  60                  


Ser Gly Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg 
65                  70                  75                  80  


Arg Tyr Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe 
                85                  90                  95      


Ser Asn Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu 
            100                 105                 110         


Glu Ser Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile 
        115                 120                 125             


Phe Gly Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr 
    130                 135                 140                 


Ile Tyr His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp 
145                 150                 155                 160 


Leu Arg Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly 
                165                 170                 175     


His Phe Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp 
            180                 185                 190         


Lys Leu Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu 
        195                 200                 205             


Asn Pro Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala 
    210                 215                 220                 


Arg Leu Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro 
225                 230                 235                 240 


Gly Glu Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu 
                245                 250                 255     


Gly Leu Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala 
            260                 265                 270         


Lys Leu Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu 
        275                 280                 285             


Leu Ala Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys 
    290                 295                 300                 


Asn Leu Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr 
305                 310                 315                 320 


Glu Ile Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp 
                325                 330                 335     


Glu His His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln 
            340                 345                 350         


Leu Pro Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly 
        355                 360                 365             


Tyr Ala Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys 
    370                 375                 380                 


Phe Ile Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu 
385                 390                 395                 400 


Val Lys Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp 
                405                 410                 415     


Asn Gly Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile 
            420                 425                 430         


Leu Arg Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu 
        435                 440                 445             


Lys Ile Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro 
    450                 455                 460                 


Leu Ala Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu 
465                 470                 475                 480 


Glu Thr Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala 
                485                 490                 495     


Ser Ala Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu 
            500                 505                 510         


Pro Asn Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe 
        515                 520                 525             


Thr Val Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met 
    530                 535                 540                 


Arg Lys Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp 
545                 550                 555                 560 


Leu Leu Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu 
                565                 570                 575     


Asp Tyr Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly 
            580                 585                 590         


Val Glu Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu 
        595                 600                 605             


Lys Ile Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp 
    610                 615                 620                 


Ile Leu Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu 
625                 630                 635                 640 


Met Ile Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys 
                645                 650                 655     


Val Met Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu 
            660                 665                 670         


Ser Arg Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr 
        675                 680                 685             


Ile Leu Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met 
    690                 695                 700                 


Gln Leu Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys 
705                 710                 715                 720 


Ala Gln Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn 
                725                 730                 735     


Leu Ala Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys 
            740                 745                 750         


Val Val Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn 
        755                 760                 765             


Ile Val Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln 
    770                 775                 780                 


Lys Asn Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu 
785                 790                 795                 800 


Leu Gly Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu 
                805                 810                 815     


Gln Asn Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met 
            820                 825                 830         


Tyr Val Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val 
        835                 840                 845             


Asp His Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn 
    850                 855                 860                 


Lys Val Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val 
865                 870                 875                 880 


Pro Ser Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu 
                885                 890                 895     


Leu Asn Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys 
            900                 905                 910         


Ala Glu Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys 
        915                 920                 925             


Arg Gln Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile 
    930                 935                 940                 


Leu Asp Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile 
945                 950                 955                 960 


Arg Glu Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe 
                965                 970                 975     


Arg Lys Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His 
            980                 985                 990         


His Ala His Asp Ala Tyr Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile 
        995                 1000                 1005             


Lys Lys  Tyr Pro Lys Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr 
    1010                 1015                 1020             


Lys Val  Tyr Asp Val Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu 
    1025                 1030                 1035             


Ile Gly  Lys Ala Thr Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met 
    1040                 1045                 1050             


Asn Phe  Phe Lys Thr Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg 
    1055                 1060                 1065             


Lys Arg  Pro Leu Ile Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val 
    1070                 1075                 1080             


Trp Asp  Lys Gly Arg Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser 
    1085                 1090                 1095             


Met Pro  Gln Val Asn Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly 
    1100                 1105                 1110             


Gly Phe  Ser Lys Glu Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys 
    1115                 1120                 1125             


Leu Ile  Ala Arg Lys Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly 
    1130                 1135                 1140             


Phe Asp  Ser Pro Thr Val Ala  Tyr Ser Val Leu Val  Val Ala Lys 
    1145                 1150                 1155             


Val Glu  Lys Gly Lys Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu 
    1160                 1165                 1170             


Leu Gly  Ile Thr Ile Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro 
    1175                 1180                 1185             


Ile Asp  Phe Leu Glu Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp 
    1190                 1195                 1200             


Leu Ile  Ile Lys Leu Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn 
    1205                 1210                 1215             


Gly Arg  Lys Arg Met Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly 
    1220                 1225                 1230             


Asn Glu  Leu Ala Leu Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu 
    1235                 1240                 1245             


Ala Ser  His Tyr Glu Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu 
    1250                 1255                 1260             


Gln Lys  Gln Leu Phe Val Glu  Gln His Lys His Tyr  Leu Asp Glu 
    1265                 1270                 1275             


Ile Ile  Glu Gln Ile Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala 
    1280                 1285                 1290             


Asp Ala  Asn Leu Asp Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg 
    1295                 1300                 1305             


Asp Lys  Pro Ile Arg Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe 
    1310                 1315                 1320             


Thr Leu  Thr Asn Leu Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp 
    1325                 1330                 1335             


Thr Thr  Ile Asp Arg Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu 
    1340                 1345                 1350             


Asp Ala  Thr Leu Ile His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr 
    1355                 1360                 1365             


Arg Ile  Asp Leu Ser Gln Leu  Gly Gly Asp Ser Arg  Ala Asp Pro 
    1370                 1375                 1380             


Lys Lys  Lys Arg Lys Val 
    1385                 


<210>  129
<211>  1399
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  129

Met Gly Ser Ser His His His His His His His His Glu Asn Leu Tyr 
1               5                   10                  15      


Phe Gln Gly Ser Met Asp Lys Lys Tyr Ser Ile Gly Leu Asp Ile Gly 
            20                  25                  30          


Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu Tyr Lys Val Pro 
        35                  40                  45              


Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg His Ser Ile Lys 
    50                  55                  60                  


Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly Glu Thr Ala Glu 
65                  70                  75                  80  


Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr Thr Arg Arg Lys 
                85                  90                  95      


Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn Glu Met Ala Lys 
            100                 105                 110         


Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser Phe Leu Val Glu 
        115                 120                 125             


Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly Asn Ile Val Asp 
    130                 135                 140                 


Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr His Leu Arg Lys 
145                 150                 155                 160 


Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg Leu Ile Tyr Leu 
                165                 170                 175     


Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe Leu Ile Glu Gly 
            180                 185                 190         


Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu Phe Ile Gln Leu 
        195                 200                 205             


Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro Ile Asn Ala Ser 
    210                 215                 220                 


Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu Ser Lys Ser Arg 
225                 230                 235                 240 


Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu Lys Lys Asn Gly 
                245                 250                 255     


Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu Thr Pro Asn Phe 
            260                 265                 270         


Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu Gln Leu Ser Lys 
        275                 280                 285             


Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala Gln Ile Gly Asp 
    290                 295                 300                 


Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu Ser Asp Ala Ile 
305                 310                 315                 320 


Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile Thr Lys Ala Pro 
                325                 330                 335     


Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His His Gln Asp Leu 
            340                 345                 350         


Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala Gly Tyr Ile Asp 
    370                 375                 380                 


Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile Lys Pro Ile Leu 
385                 390                 395                 400 


Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys Leu Asn Arg Glu 
                405                 410                 415     


Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly Ser Ile Pro His 
            420                 425                 430         


Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg Arg Gln Glu Asp 
        435                 440                 445             


Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile Glu Lys Ile Leu 
    450                 455                 460                 


Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala Arg Gly Asn Ser 
465                 470                 475                 480 


Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr Ile Thr Pro Trp 
                485                 490                 495     


Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala Gln Ser Phe Ile 
            500                 505                 510         


Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn Glu Lys Val Leu 
        515                 520                 525             


Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val Tyr Asn Glu Leu 
    530                 535                 540                 


Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys Pro Ala Phe Leu 
545                 550                 555                 560 


Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu Phe Lys Thr Asn 
                565                 570                 575     


Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr Phe Lys Lys Ile 
            580                 585                 590         


Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu Asp Arg Phe Asn 
        595                 600                 605             


Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile Ile Lys Asp Lys 
    610                 615                 620                 


Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu Glu Asp Ile Val 
625                 630                 635                 640 


Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile Glu Glu Arg Leu 
                645                 650                 655     


Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met Lys Gln Leu Lys 
            660                 665                 670         


Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg Lys Leu Ile Asn 
        675                 680                 685             


Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu Asp Phe Leu Lys 
    690                 695                 700                 


Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu Ile His Asp Asp 
705                 710                 715                 720 


Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln Val Ser Gly Gln 
                725                 730                 735     


Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala Gly Ser Pro Ala 
            740                 745                 750         


Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val Asp Glu Leu Val 
        755                 760                 765             


Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val Ile Glu Met Ala 
    770                 775                 780                 


Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn Ser Arg Glu Arg 
785                 790                 795                 800 


Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly Ser Gln Ile Leu 
                805                 810                 815     


Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn Glu Lys Leu Tyr 
            820                 825                 830         


Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val Asp Gln Glu Leu 
        835                 840                 845             


Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His Ile Val Pro Gln 
    850                 855                 860                 


Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val Leu Thr Arg Ser 
865                 870                 875                 880 


Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser Glu Glu Val Val 
                885                 890                 895     


Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn Ala Lys Leu Ile 
            900                 905                 910         


Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu Arg Gly Gly Leu 
        915                 920                 925             


Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln Leu Val Glu Thr 
    930                 935                 940                 


Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp Ser Arg Met Asn 
945                 950                 955                 960 


Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu Val Lys Val Ile 
                965                 970                 975     


Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys Asp Phe Gln Phe 
            980                 985                 990         


Tyr Lys Val Arg Glu Ile Asn Asn  Tyr His His Ala His  Asp Ala Tyr 
        995                 1000                 1005             


Leu Asn  Ala Val Val Gly Thr  Ala Leu Ile Lys Lys  Tyr Pro Lys 
    1010                 1015                 1020             


Leu Glu  Ser Glu Phe Val Tyr  Gly Asp Tyr Lys Val  Tyr Asp Val 
    1025                 1030                 1035             


Arg Lys  Met Ile Ala Lys Ser  Glu Gln Glu Ile Gly  Lys Ala Thr 
    1040                 1045                 1050             


Ala Lys  Tyr Phe Phe Tyr Ser  Asn Ile Met Asn Phe  Phe Lys Thr 
    1055                 1060                 1065             


Glu Ile  Thr Leu Ala Asn Gly  Glu Ile Arg Lys Arg  Pro Leu Ile 
    1070                 1075                 1080             


Glu Thr  Asn Gly Glu Thr Gly  Glu Ile Val Trp Asp  Lys Gly Arg 
    1085                 1090                 1095             


Asp Phe  Ala Thr Val Arg Lys  Val Leu Ser Met Pro  Gln Val Asn 
    1100                 1105                 1110             


Ile Val  Lys Lys Thr Glu Val  Gln Thr Gly Gly Phe  Ser Lys Glu 
    1115                 1120                 1125             


Ser Ile  Leu Pro Lys Arg Asn  Ser Asp Lys Leu Ile  Ala Arg Lys 
    1130                 1135                 1140             


Lys Asp  Trp Asp Pro Lys Lys  Tyr Gly Gly Phe Asp  Ser Pro Thr 
    1145                 1150                 1155             


Val Ala  Tyr Ser Val Leu Val  Val Ala Lys Val Glu  Lys Gly Lys 
    1160                 1165                 1170             


Ser Lys  Lys Leu Lys Ser Val  Lys Glu Leu Leu Gly  Ile Thr Ile 
    1175                 1180                 1185             


Met Glu  Arg Ser Ser Phe Glu  Lys Asn Pro Ile Asp  Phe Leu Glu 
    1190                 1195                 1200             


Ala Lys  Gly Tyr Lys Glu Val  Lys Lys Asp Leu Ile  Ile Lys Leu 
    1205                 1210                 1215             


Pro Lys  Tyr Ser Leu Phe Glu  Leu Glu Asn Gly Arg  Lys Arg Met 
    1220                 1225                 1230             


Leu Ala  Ser Ala Gly Glu Leu  Gln Lys Gly Asn Glu  Leu Ala Leu 
    1235                 1240                 1245             


Pro Ser  Lys Tyr Val Asn Phe  Leu Tyr Leu Ala Ser  His Tyr Glu 
    1250                 1255                 1260             


Lys Leu  Lys Gly Ser Pro Glu  Asp Asn Glu Gln Lys  Gln Leu Phe 
    1265                 1270                 1275             


Val Glu  Gln His Lys His Tyr  Leu Asp Glu Ile Ile  Glu Gln Ile 
    1280                 1285                 1290             


Ser Glu  Phe Ser Lys Arg Val  Ile Leu Ala Asp Ala  Asn Leu Asp 
    1295                 1300                 1305             


Lys Val  Leu Ser Ala Tyr Asn  Lys His Arg Asp Lys  Pro Ile Arg 
    1310                 1315                 1320             


Glu Gln  Ala Glu Asn Ile Ile  His Leu Phe Thr Leu  Thr Asn Leu 
    1325                 1330                 1335             


Gly Ala  Pro Ala Ala Phe Lys  Tyr Phe Asp Thr Thr  Ile Asp Arg 
    1340                 1345                 1350             


Lys Arg  Tyr Thr Ser Thr Lys  Glu Val Leu Asp Ala  Thr Leu Ile 
    1355                 1360                 1365             


His Gln  Ser Ile Thr Gly Leu  Tyr Glu Thr Arg Ile  Asp Leu Ser 
    1370                 1375                 1380             


Gln Leu  Gly Gly Asp Gly Gly  Gly Ser Pro Lys Lys  Lys Arg Lys 
    1385                 1390                 1395             


Val 
    


<210>  130
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  130

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Ala Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  131
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  131

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Ala Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Ala Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Ala 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  132
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  132

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Asn Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Arg Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Gln Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Ala Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Gln Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Ala Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Ala 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  133
<211>  1393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic polypeptide

<400>  133

Met Ala Pro Lys Lys Lys Arg Lys Val Asp Lys Lys Tyr Ser Ile Gly 
1               5                   10                  15      


Leu Asp Ile Gly Thr Asn Ser Val Gly Trp Ala Val Ile Thr Asp Glu 
            20                  25                  30          


Tyr Lys Val Pro Ser Lys Lys Phe Lys Val Leu Gly Asn Thr Asp Arg 
        35                  40                  45              


His Ser Ile Lys Lys Asn Leu Ile Gly Ala Leu Leu Phe Asp Ser Gly 
    50                  55                  60                  


Glu Thr Ala Glu Ala Thr Arg Leu Lys Arg Thr Ala Arg Arg Arg Tyr 
65                  70                  75                  80  


Thr Arg Arg Lys Asn Arg Ile Cys Tyr Leu Gln Glu Ile Phe Ser Asn 
                85                  90                  95      


Glu Met Ala Lys Val Asp Asp Ser Phe Phe His Arg Leu Glu Glu Ser 
            100                 105                 110         


Phe Leu Val Glu Glu Asp Lys Lys His Glu Arg His Pro Ile Phe Gly 
        115                 120                 125             


Asn Ile Val Asp Glu Val Ala Tyr His Glu Lys Tyr Pro Thr Ile Tyr 
    130                 135                 140                 


His Leu Arg Lys Lys Leu Val Asp Ser Thr Asp Lys Ala Asp Leu Arg 
145                 150                 155                 160 


Leu Ile Tyr Leu Ala Leu Ala His Met Ile Lys Phe Arg Gly His Phe 
                165                 170                 175     


Leu Ile Glu Gly Asp Leu Asn Pro Asp Asn Ser Asp Val Asp Lys Leu 
            180                 185                 190         


Phe Ile Gln Leu Val Gln Thr Tyr Asn Gln Leu Phe Glu Glu Asn Pro 
        195                 200                 205             


Ile Asn Ala Ser Gly Val Asp Ala Lys Ala Ile Leu Ser Ala Arg Leu 
    210                 215                 220                 


Ser Lys Ser Arg Arg Leu Glu Asn Leu Ile Ala Gln Leu Pro Gly Glu 
225                 230                 235                 240 


Lys Lys Asn Gly Leu Phe Gly Asn Leu Ile Ala Leu Ser Leu Gly Leu 
                245                 250                 255     


Thr Pro Asn Phe Lys Ser Asn Phe Asp Leu Ala Glu Asp Ala Lys Leu 
            260                 265                 270         


Gln Leu Ser Lys Asp Thr Tyr Asp Asp Asp Leu Asp Asn Leu Leu Ala 
        275                 280                 285             


Gln Ile Gly Asp Gln Tyr Ala Asp Leu Phe Leu Ala Ala Lys Asn Leu 
    290                 295                 300                 


Ser Asp Ala Ile Leu Leu Ser Asp Ile Leu Arg Val Asn Thr Glu Ile 
305                 310                 315                 320 


Thr Lys Ala Pro Leu Ser Ala Ser Met Ile Lys Arg Tyr Asp Glu His 
                325                 330                 335     


His Gln Asp Leu Thr Leu Leu Lys Ala Leu Val Arg Gln Gln Leu Pro 
            340                 345                 350         


Glu Lys Tyr Lys Glu Ile Phe Phe Asp Gln Ser Lys Asn Gly Tyr Ala 
        355                 360                 365             


Gly Tyr Ile Asp Gly Gly Ala Ser Gln Glu Glu Phe Tyr Lys Phe Ile 
    370                 375                 380                 


Lys Pro Ile Leu Glu Lys Met Asp Gly Thr Glu Glu Leu Leu Val Lys 
385                 390                 395                 400 


Leu Asn Arg Glu Asp Leu Leu Arg Lys Gln Arg Thr Phe Asp Asn Gly 
                405                 410                 415     


Ser Ile Pro His Gln Ile His Leu Gly Glu Leu His Ala Ile Leu Arg 
            420                 425                 430         


Arg Gln Glu Asp Phe Tyr Pro Phe Leu Lys Asp Asn Arg Glu Lys Ile 
        435                 440                 445             


Glu Lys Ile Leu Thr Phe Arg Ile Pro Tyr Tyr Val Gly Pro Leu Ala 
    450                 455                 460                 


Arg Gly Asn Ser Arg Phe Ala Trp Met Thr Arg Lys Ser Glu Glu Thr 
465                 470                 475                 480 


Ile Thr Pro Trp Asn Phe Glu Glu Val Val Asp Lys Gly Ala Ser Ala 
                485                 490                 495     


Gln Ser Phe Ile Glu Arg Met Thr Ala Phe Asp Lys Asn Leu Pro Asn 
            500                 505                 510         


Glu Lys Val Leu Pro Lys His Ser Leu Leu Tyr Glu Tyr Phe Thr Val 
        515                 520                 525             


Tyr Asn Glu Leu Thr Lys Val Lys Tyr Val Thr Glu Gly Met Arg Lys 
    530                 535                 540                 


Pro Ala Phe Leu Ser Gly Glu Gln Lys Lys Ala Ile Val Asp Leu Leu 
545                 550                 555                 560 


Phe Lys Thr Asn Arg Lys Val Thr Val Lys Gln Leu Lys Glu Asp Tyr 
                565                 570                 575     


Phe Lys Lys Ile Glu Cys Phe Asp Ser Val Glu Ile Ser Gly Val Glu 
            580                 585                 590         


Asp Arg Phe Asn Ala Ser Leu Gly Thr Tyr His Asp Leu Leu Lys Ile 
        595                 600                 605             


Ile Lys Asp Lys Asp Phe Leu Asp Asn Glu Glu Asn Glu Asp Ile Leu 
    610                 615                 620                 


Glu Asp Ile Val Leu Thr Leu Thr Leu Phe Glu Asp Arg Glu Met Ile 
625                 630                 635                 640 


Glu Glu Arg Leu Lys Thr Tyr Ala His Leu Phe Asp Asp Lys Val Met 
                645                 650                 655     


Lys Gln Leu Lys Arg Arg Arg Tyr Thr Gly Trp Gly Ala Leu Ser Arg 
            660                 665                 670         


Lys Leu Ile Asn Gly Ile Arg Asp Lys Gln Ser Gly Lys Thr Ile Leu 
        675                 680                 685             


Asp Phe Leu Lys Ser Asp Gly Phe Ala Asn Arg Asn Phe Met Ala Leu 
    690                 695                 700                 


Ile His Asp Asp Ser Leu Thr Phe Lys Glu Asp Ile Gln Lys Ala Gln 
705                 710                 715                 720 


Val Ser Gly Gln Gly Asp Ser Leu His Glu His Ile Ala Asn Leu Ala 
                725                 730                 735     


Gly Ser Pro Ala Ile Lys Lys Gly Ile Leu Gln Thr Val Lys Val Val 
            740                 745                 750         


Asp Glu Leu Val Lys Val Met Gly Arg His Lys Pro Glu Asn Ile Val 
        755                 760                 765             


Ile Glu Met Ala Arg Glu Asn Gln Thr Thr Gln Lys Gly Gln Lys Asn 
    770                 775                 780                 


Ser Arg Glu Arg Met Lys Arg Ile Glu Glu Gly Ile Lys Glu Leu Gly 
785                 790                 795                 800 


Ser Gln Ile Leu Lys Glu His Pro Val Glu Asn Thr Gln Leu Gln Asn 
                805                 810                 815     


Glu Lys Leu Tyr Leu Tyr Tyr Leu Gln Asn Gly Arg Asp Met Tyr Val 
            820                 825                 830         


Asp Gln Glu Leu Asp Ile Asn Arg Leu Ser Asp Tyr Asp Val Asp His 
        835                 840                 845             


Ile Val Pro Gln Ser Phe Leu Lys Asp Asp Ser Ile Asp Asn Lys Val 
    850                 855                 860                 


Leu Thr Arg Ser Asp Lys Asn Arg Gly Lys Ser Asp Asn Val Pro Ser 
865                 870                 875                 880 


Glu Glu Val Val Lys Lys Met Lys Asn Tyr Trp Arg Gln Leu Leu Asn 
                885                 890                 895     


Ala Lys Leu Ile Thr Gln Arg Lys Phe Asp Asn Leu Thr Lys Ala Glu 
            900                 905                 910         


Arg Gly Gly Leu Ser Glu Leu Asp Lys Ala Gly Phe Ile Lys Arg Gln 
        915                 920                 925             


Leu Val Glu Thr Arg Ala Ile Thr Lys His Val Ala Gln Ile Leu Asp 
    930                 935                 940                 


Ser Arg Met Asn Thr Lys Tyr Asp Glu Asn Asp Lys Leu Ile Arg Glu 
945                 950                 955                 960 


Val Lys Val Ile Thr Leu Lys Ser Lys Leu Val Ser Asp Phe Arg Lys 
                965                 970                 975     


Asp Phe Gln Phe Tyr Lys Val Arg Glu Ile Asn Asn Tyr His His Ala 
            980                 985                 990         


His Asp Ala Tyr Leu Asn Ala Val  Val Gly Thr Ala Leu  Ile Lys Lys 
        995                 1000                 1005             


Tyr Pro  Lys Leu Glu Ser Glu  Phe Val Tyr Gly Asp  Tyr Lys Val 
    1010                 1015                 1020             


Tyr Asp  Val Arg Lys Met Ile  Ala Lys Ser Glu Gln  Glu Ile Gly 
    1025                 1030                 1035             


Lys Ala  Thr Ala Lys Tyr Phe  Phe Tyr Ser Asn Ile  Met Asn Phe 
    1040                 1045                 1050             


Phe Lys  Thr Glu Ile Thr Leu  Ala Asn Gly Glu Ile  Arg Lys Arg 
    1055                 1060                 1065             


Pro Leu  Ile Glu Thr Asn Gly  Glu Thr Gly Glu Ile  Val Trp Asp 
    1070                 1075                 1080             


Lys Gly  Arg Asp Phe Ala Thr  Val Arg Lys Val Leu  Ser Met Pro 
    1085                 1090                 1095             


Gln Val  Asn Ile Val Lys Lys  Thr Glu Val Gln Thr  Gly Gly Phe 
    1100                 1105                 1110             


Ser Lys  Glu Ser Ile Leu Pro  Lys Arg Asn Ser Asp  Lys Leu Ile 
    1115                 1120                 1125             


Ala Arg  Lys Lys Asp Trp Asp  Pro Lys Lys Tyr Gly  Gly Phe Asp 
    1130                 1135                 1140             


Ser Pro  Thr Val Ala Tyr Ser  Val Leu Val Val Ala  Lys Val Glu 
    1145                 1150                 1155             


Lys Gly  Lys Ser Lys Lys Leu  Lys Ser Val Lys Glu  Leu Leu Gly 
    1160                 1165                 1170             


Ile Thr  Ile Met Glu Arg Ser  Ser Phe Glu Lys Asn  Pro Ile Asp 
    1175                 1180                 1185             


Phe Leu  Glu Ala Lys Gly Tyr  Lys Glu Val Lys Lys  Asp Leu Ile 
    1190                 1195                 1200             


Ile Lys  Leu Pro Lys Tyr Ser  Leu Phe Glu Leu Glu  Asn Gly Arg 
    1205                 1210                 1215             


Lys Arg  Met Leu Ala Ser Ala  Gly Glu Leu Gln Lys  Gly Asn Glu 
    1220                 1225                 1230             


Leu Ala  Leu Pro Ser Lys Tyr  Val Asn Phe Leu Tyr  Leu Ala Ser 
    1235                 1240                 1245             


His Tyr  Glu Lys Leu Lys Gly  Ser Pro Glu Asp Asn  Glu Gln Lys 
    1250                 1255                 1260             


Gln Leu  Phe Val Glu Gln His  Lys His Tyr Leu Asp  Glu Ile Ile 
    1265                 1270                 1275             


Glu Gln  Ile Ser Glu Phe Ser  Lys Arg Val Ile Leu  Ala Asp Ala 
    1280                 1285                 1290             


Asn Leu  Asp Lys Val Leu Ser  Ala Tyr Asn Lys His  Arg Asp Lys 
    1295                 1300                 1305             


Pro Ile  Arg Glu Gln Ala Glu  Asn Ile Ile His Leu  Phe Thr Leu 
    1310                 1315                 1320             


Thr Asn  Leu Gly Ala Pro Ala  Ala Phe Lys Tyr Phe  Asp Thr Thr 
    1325                 1330                 1335             


Ile Asp  Arg Lys Arg Tyr Thr  Ser Thr Lys Glu Val  Leu Asp Ala 
    1340                 1345                 1350             


Thr Leu  Ile His Gln Ser Ile  Thr Gly Leu Tyr Glu  Thr Arg Ile 
    1355                 1360                 1365             


Asp Leu  Ser Gln Leu Gly Gly  Asp Ser Arg Ala Asp  Pro Lys Lys 
    1370                 1375                 1380             


Lys Arg  Lys Val His His His  His His His 
    1385                 1390             


<210>  134
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  134
ggccacggag cgagacaucu                                                   20


<210>  135
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  135
cgcgagcaca gcuaaggcca                                                   20


<210>  136
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  136
aggguaggag agacucacgc                                                   20


<210>  137
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  137
cacagcccaa gauaguuaag                                                   20


<210>  138
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  138
uuaccccacu uaacuaucuu                                                   20


<210>  139
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  139
cuuaccccac uuaacuaucu                                                   20


<210>  140
<211>  20
<212>  RNA
<213>  Homo sapiens

<400>  140
uccugaauug cuaugugucu                                                   20


<210>  141
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  141
gagtagcgcg agcacagcta                                                   20


<210>  142
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  142
cgtgagtaaa cctgaatctt                                                   20


<210>  143
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  143
aagtcaactt caatgtcgga                                                   20


<210>  144
<211>  20
<212>  DNA
<213>  Homosapiens

<400>  144
cagtaagtca acttcaatgt                                                   20


<210>  145
<211>  20
<212>  DNA
<213>  Homosapiens

<400>  145
ctgaatcttt ggagtacctg                                                   20


<210>  146
<211>  20
<212>  DNA
<213>  Homosapiens

<400>  146
ggccgagatg tctcgctccg                                                   20


<210>  147
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  147
ctcgcgctac tctctctttc                                                   20


<210>  148
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  148
actcacgctg gatagcctcc                                                   20


<210>  149
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  149
tcacgtcatc cagcagagaa                                                   20


<210>  150
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  150
agtcacatgg ttcacacggc                                                   20


<210>  151
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  151
ccacctcttg atggggctag                                                   20


<210>  152
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  152
gctactctct ctttctggcc                                                   20


<210>  153
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  153
ggccacggag cgagacatct                                                   20


<210>  154
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  154
cgcgagcaca gctaaggcca                                                   20


<210>  155
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  155
agggtaggag agactcacgc                                                   20


<210>  156
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  156
cacagcccaa gatagttaag                                                   20


<210>  157
<211>  20
<212>  DNA
<213>  Homo sapiens

<400>  157
ttaccccact taactatctt                                                   20


<210>  158
<211>  20
<212>  DNA
<213>  Homos apiens

<400>  158
cttaccccac ttaactatct                                                   20


<210>  159
<211>  20
<212>  DNA
<213>  Homosapiens

<400>  159
tcctgaattg ctatgtgtct                                                   20


<210>  160
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  160
cgugaguaaa ccugaaucuu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  161
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  161
aagucaacuu caaugucgga guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  162
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  162
caguaaguca acuucaaugu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  163
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  163
cugaaucuuu ggaguaccug guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  164
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  164
ggccgagaug ucucgcuccg guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  165
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  165
cucgcgcuac ucucucuuuc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  166
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  166
acucacgcug gauagccucc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  167
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  167
ucacgucauc cagcagagaa guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  168
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  168
agucacaugg uucacacggc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  169
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  169
ccaccucuug auggggcuag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  170
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  170
gcuacucucu cuuucuggcc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  171
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  171
ggccacggag cgagacaucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  172
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  172
cgcgagcaca gcuaaggcca guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  173
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  173
aggguaggag agacucacgc guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  174
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynucleotide

<400>  174
cacagcccaa gauaguuaag guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  175
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  175
uuaccccacu uaacuaucuu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  176
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  176
cuuaccccac uuaacuaucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  177
<211>  100
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  177
uccugaauug cuaugugucu guuuuagagc uagaaauagc aaguuaaaau aaggcuaguc       60

cguuaucaac uugaaaaagu ggcaccgagu cggugcuuuu                            100


<210>  178
<211>  20
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic polynuceotide

<400>  178
gacccccucc accccgccuc                                                   20


<210>  179
<211>  11
<212>  DNA
<213>  Unknown

<220>
<223>  Target sequence


<220>
<221>  modified_base
<222>  (1)..(9)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(9)
<223>  n is a, c, g, or t

<400>  179
nnnnnnnnng g                                                            11


<210>  180
<211>  13
<212>  DNA
<213>  Unknown

<220>
<223>  target sequence


<220>
<221>  modified_base
<222>  (1)..(8)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(8)
<223>  n is a, c, g, or t

<400>  180
nnnnnnnnag aaw                                                          13


<210>  181
<211>  18
<212>  DNA
<213>  Unknown

<220>
<223>  target sequence


<220>
<221>  modified_base
<222>  (1)..(13)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<400>  181
nnnnnnnnnn nnnagaaw                                                     18


<210>  182
<211>  17
<212>  DNA
<213>  Unknown

<220>
<223>  target sequence


<220>
<221>  modified_base
<222>  (1)..(13)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (1)..(13)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  n is a, c, g, or t

<400>  182
nnnnnnnnnn nnnggng                                                      17


<210>  183
<211>  25
<212>  DNA
<213>  Unknown

<220>
<223>  target sequence


<220>
<221>  modified_base
<222>  (10)..(21)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (10)..(21)
<223>  n is a, c, g, or t

<220>
<221>  modified_base
<222>  (24)..(24)
<223>  a, c, t, g, unknown or other

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  n is a, c, g, or t

<400>  183
mmmmmmmmmn nnnnnnnnnn nggng                                             25


