﻿               SEQUENCE LISTING

<110> Atlas Biotechnology S.A.

<120> Treatment and/or prevention of a disease or a syndrome related to a virus infection

<130> AD2955 PCT BS

<160> 47

<170> BiSSAP 1.3.6

<210> 1
<211> 418
<212> PRT
<213> Artificial Sequence


<220> 
<223> Alpha1-Antitrypsin (AAT)

<400> 1
Met Pro Ser Ser Val Ser Trp Gly Ile Leu Leu Leu Ala Gly Leu Cys 
1               5                   10                  15      
Cys Leu Val Pro Val Ser Leu Ala Glu Asp Pro Gln Gly Asp Ala Ala 
            20                  25                  30          
Gln Lys Thr Asp Thr Ser His His Asp Gln Asp His Pro Thr Phe Asn 
        35                  40                  45              
Lys Ile Thr Pro Asn Leu Ala Glu Phe Ala Phe Ser Leu Tyr Arg Gln 
    50                  55                  60                  
Leu Ala His Gln Ser Asn Ser Thr Asn Ile Phe Phe Ser Pro Val Ser 
65                  70                  75                  80  
Ile Ala Thr Ala Phe Ala Met Leu Ser Leu Gly Thr Lys Ala Asp Thr 
                85                  90                  95      
His Asp Glu Ile Leu Glu Gly Leu Asn Phe Asn Leu Thr Glu Ile Pro 
            100                 105                 110         
Glu Ala Gln Ile His Glu Gly Phe Gln Glu Leu Leu Arg Thr Leu Asn 
        115                 120                 125             
Gln Pro Asp Ser Gln Leu Gln Leu Thr Thr Gly Asn Gly Leu Phe Leu 
    130                 135                 140                 
Ser Glu Gly Leu Lys Leu Val Asp Lys Phe Leu Glu Asp Val Lys Lys 
145                 150                 155                 160 
Leu Tyr His Ser Glu Ala Phe Thr Val Asn Phe Gly Asp Thr Glu Glu 
                165                 170                 175     
Ala Lys Lys Gln Ile Asn Asp Tyr Val Glu Lys Gly Thr Gln Gly Lys 
            180                 185                 190         
Ile Val Asp Leu Val Lys Glu Leu Asp Arg Asp Thr Val Phe Ala Leu 
        195                 200                 205             
Val Asn Tyr Ile Phe Phe Lys Gly Lys Trp Glu Arg Pro Phe Glu Val 
    210                 215                 220                 
Lys Asp Thr Glu Glu Glu Asp Phe His Val Asp Gln Val Thr Thr Val 
225                 230                 235                 240 
Lys Val Pro Met Met Lys Arg Leu Gly Met Phe Asn Ile Gln His Cys 
                245                 250                 255     
Lys Lys Leu Ser Ser Trp Val Leu Leu Met Lys Tyr Leu Gly Asn Ala 
            260                 265                 270         
Thr Ala Ile Phe Phe Leu Pro Asp Glu Gly Lys Leu Gln His Leu Glu 
        275                 280                 285             
Asn Glu Leu Thr His Asp Ile Ile Thr Lys Phe Leu Glu Asn Glu Asp 
    290                 295                 300                 
Arg Arg Ser Ala Ser Leu His Leu Pro Lys Leu Ser Ile Thr Gly Thr 
305                 310                 315                 320 
Tyr Asp Leu Lys Ser Val Leu Gly Gln Leu Gly Ile Thr Lys Val Phe 
                325                 330                 335     
Ser Asn Gly Ala Asp Leu Ser Gly Val Thr Glu Glu Ala Pro Leu Lys 
            340                 345                 350         
Leu Ser Lys Ala Val His Lys Ala Val Leu Thr Ile Asp Glu Lys Gly 
        355                 360                 365             
Thr Glu Ala Ala Gly Ala Met Phe Leu Glu Ala Ile Pro Met Ser Ile 
    370                 375                 380                 
Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Phe Leu Met Ile Glu 
385                 390                 395                 400 
Gln Asn Thr Lys Ser Pro Leu Phe Met Gly Lys Val Val Asn Pro Thr 
                405                 410                 415     
Gln Lys 
        

<210> 2
<211> 44
<212> PRT
<213> Artificial Sequence


<220> 
<223> C-terminal AAT sequence 374-418

<400> 2
Met Phe Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe 
1               5                   10                  15      
Asn Lys Pro Phe Val Phe Leu Met Ile Glu Gln Asn Thr Lys Ser Pro 
            20                  25                  30          
Leu Phe Met Gly Lys Val Val Asn Pro Thr Gln Lys 
        35                  40                  

<210> 3
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> short cyclic peptide derived from the C-terminal sequence of
      Alpha1-Antitrypsin

<400> 3
Cys Pro Phe Val Phe Leu Met 
1               5           

<210> 4
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> short cyclic peptide derived from the C-terminal sequence of
      Alpha1-Antitrypsin

<400> 4
Cys Pro Phe Val Phe Leu Glu 
1               5           

<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> short cyclic peptide derived from the C-terminal sequence of
      Alpha1-Antitrypsin

<400> 5
Cys Pro Phe Val Phe Leu Arg 
1               5           

<210> 6
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> short cyclic peptide derived from the C-terminal sequence of
      Alpha1-Antitrypsin

<400> 6
Cys Pro Glu Val Phe Leu Met 
1               5           

<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> HIV-TAT 48-57 peptide

<400> 7
Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10  

<210> 8
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> FHV-coat 35-49 peptide

<400> 8
Arg Arg Arg Arg Asn Arg Thr Arg Arg Asn Arg Arg Arg Val Arg 
1               5                   10                  15  

<210> 9
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> HTLV-II Rex 4-16 peptide

<400> 9
Thr Arg Arg Gln Arg Thr Arg Arg Ala Arg Arg Asn Arg 
1               5                   10              

<210> 10
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> BMV gag 7-25 peptide

<400> 10
Lys Met Thr Arg Ala Gln Arg Arg Ala Ala Ala Arg Arg Asn Arg Trp 
1               5                   10                  15      
Thr Ala Arg 
            

<210> 11
<211> 11
<212> PRT
<213> Viruses


<220> 
<223> Fluorogenic peptides derived from SARS-CoV spike

<400> 11
His Thr Val Ser Leu Leu Arg Ser Thr Ser Gln 
1               5                   10      

<210> 12
<211> 11
<212> PRT
<213> Viruses


<220> 
<223> Fluorogenic peptides derived from SARS-CoV-2 spike

<400> 12
Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
1               5                   10      

<210> 13
<211> 7394
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCDH-CMV-MCS-EF1α-Puro lentivector

<400> 13
acgcgtgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca       60

acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta      120

cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga      180

attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc      240

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      300

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      360

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg      420

cccgaacagg gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct      480

tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt      540

gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag      600

aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt      660

aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt      720

agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg      780

atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag      840

gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag      900

taagaccacc gcacagcaag cggccactga tcttcagacc tggaggagga gatatgaggg      960

acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag     1020

cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag     1080

ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc     1140

tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga     1200

gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc     1260

aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg     1320

gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata     1380

aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca     1440

attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg     1500

aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa     1560

attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa     1620

tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt     1680

ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag     1740

gtggagagag agacagagac agatccattc gattagtgaa cggatctcga cggtatcggt     1800

taacttttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca     1860

taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa ttcaaaattt     1920

tatcgattac tagtattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2040

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2100

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2160

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtt tatataagca gagctcgttt     2220

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagatt     2280

ctagagctag cgaattcgaa tttaaatcgg atccgcggcc gcaaggatct gcgatcgctc     2340

cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg     2400

ggtcggcaat tgaacgggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt     2460

cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt     2520

cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacagctga agcttcgagg     2580

ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc cacgccggtt     2640

gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt     2700

aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga gcctacctag     2760

actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctacg tctttgtttc     2820

gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg gcgcctacga tatgaccgag     2880

tacaagccca cggtgcgcct cgccacccgc gacgacgtcc ccagggccgt acgcaccctc     2940

gccgccgcgt tcgccgacta ccccgccacg cgccacaccg tcgatccgga ccgccacatc     3000

gagcgggtca ccgagctgca agaactcttc ctcacgcgcg tcgggctcga catcggcaag     3060

gtgtgggtcg cggacgacgg cgccgcggtg gcggtctgga ccacgccgga gagcgtcgaa     3120

gcgggggcgg tgttcgccga gatcggcccg cgcatggccg agttgagcgg ttcccggctg     3180

gccgcgcagc aacagatgga aggcctcctg gcgccgcacc ggcccaagga gcccgcgtgg     3240

ttcctggcca ccgtcggcgt ctcgcccgac caccagggca agggtctggg cagcgccgtc     3300

gtgctccccg gagtggaggc ggccgagcgc gccggggtgc ccgccttcct ggagacctcc     3360

gcgccccgca acctcccctt ctacgagcgg ctcggcttca ccgtcaccgc cgacgtcgag     3420

gtgcccgaag gaccgcgcac ctggtgcatg acccgcaagc ccggtgcctg acaatcaacc     3480

tctggattac aaaatttgtg aaagattgac tggtattctt aactatgttg ctccttttac     3540

gctatgtgga tacgctgctt taatgccttt gtatcatgct attgcttccc gtatggcttt     3600

cattttctcc tccttgtata aatcctggtt gctgtctctt tatgaggagt tgtggcccgt     3660

tgtcaggcaa cgtggcgtgg tgtgcactgt gtttgctgac gcaaccccca ctggttgggg     3720

cattgccacc acctgtcagc tcctttccgg gactttcgct ttccccctcc ctattgccac     3780

ggcggaactc atcgccgcct gccttgcccg ctgctggaca ggggctcggc tgttgggcac     3840

tgacaattcc gtggtgttgt cggggaaatc atcgtccttt ccttggctgc tcgcctgtgt     3900

tgccacctgg attctgcgcg ggacgtcctt ctgctacgtc ccttcggccc tcaatccagc     3960

ggaccttcct tcccgcggcc tgctgccggc tctgcggcct cttccgcgtc ttcgccttcg     4020

ccctcagacg agtcggatct ccctttgggc cgcctccccg cctggtacct ttaagaccaa     4080

tgacttacaa ggcagctgta gatcttagcc actttttaaa agaaaagggg ggactggaag     4140

ggctaattca ctcccaacga agataagatc tgctttttgc ttgtactggg tctctctggt     4200

tagaccagat ctgagcctgg gagctctctg gctaactagg gaacccactg cttaagcctc     4260

aataaagctt gccttgagtg cttcaagtag tgtgtgcccg tctgttgtgt gactctggta     4320

actagagatc cctcagaccc ttttagtcag tgtggaaaat ctctagcagt agtagttcat     4380

gtcatcttat tattcagtat ttataacttg caaagaaatg aatatcagag agtgagagga     4440

acttgtttat tgcagcttat aatggttaca aataaagcaa tagcatcaca aatttcacaa     4500

ataaagcatt tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt     4560

atcatgtctg gctctagcta tcccgcccct aactccgccc atcccgcccc taactccgcc     4620

cagttccgcc cattctccgc cccatggctg actaattttt tttatttatg cagaggccga     4680

ggccgcctcg gcctctgagc tattccagaa gtagtgagga ggcttttttg gaggcctaga     4740

cttttgcaga gaccaaattc gtaatcatgt catagctgtt tcctgtgtga aattgttatc     4800

cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4860

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4920

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4980

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     5040

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     5100

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     5160

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     5220

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     5280

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     5340

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5400

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5460

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5520

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5580

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     5640

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5700

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     5760

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     5820

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     5880

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     5940

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     6000

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     6060

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     6120

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     6180

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     6240

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     6300

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     6360

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     6420

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     6480

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     6540

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     6600

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     6660

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     6720

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     6780

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     6840

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     6900

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     6960

aaaataggcg tatcacgagg ccctttcgtc tcgcgcgttt cggtgatgac ggtgaaaacc     7020

tctgacacat gcagctcccg gagacggtca cagcttgtct gtaagcggat gccgggagca     7080

gacaagcccg tcagggcgcg tcagcgggtg ttggcgggtg tcggggctgg cttaactatg     7140

cggcatcaga gcagattgta ctgagagtgc accatatgcg gtgtgaaata ccgcacagat     7200

gcgtaaggag aaaataccgc atcaggcgcc attcgccatt caggctgcgc aactgttggg     7260

aagggcgatc ggtgcgggcc tcttcgctat tacgccagct ggcgaaaggg ggatgtgctg     7320

caaggcgatt aagttgggta acgccagggt tttcccagtc acgacgttgt aaaacgacgg     7380

ccagtgccaa gctg                                                       7394


<210> 14
<211> 7193
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCDH-CMV-MCS-EF1α-Blast lentivector

<400> 14
acgcgtgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca       60

acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta      120

cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga      180

attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc      240

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      300

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      360

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg      420

cccgaacagg gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct      480

tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt      540

gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag      600

aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt      660

aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt      720

agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg      780

atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag      840

gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag      900

taagaccacc gcacagcaag cggccactga tcttcagacc tggaggagga gatatgaggg      960

acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag     1020

cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag     1080

ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc     1140

tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga     1200

gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc     1260

aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg     1320

gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata     1380

aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca     1440

attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg     1500

aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa     1560

attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa     1620

tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt     1680

ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag     1740

gtggagagag agacagagac agatccattc gattagtgaa cggatctcga cggtatcggt     1800

taacttttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca     1860

taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa ttcaaaattt     1920

tatcgattac tagtattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2040

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2100

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2160

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtt tatataagca gagctcgttt     2220

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagatt     2280

ctagagctag cgaattcgaa tttaaatcgg atccgcggcc gcaaggatct gcgatcgctc     2340

cggtgcccgt cagtgggcag agcgcacatc gcccacagtc cccgagaagt tggggggagg     2400

ggtcggcaat tgaacgggtg cctagagaag gtggcgcggg gtaaactggg aaagtgatgt     2460

cgtgtactgg ctccgccttt ttcccgaggg tgggggagaa ccgtatataa gtgcagtagt     2520

cgccgtgaac gttctttttc gcaacgggtt tgccgccaga acacagctga agcttcgagg     2580

ggctcgcatc tctccttcac gcgcccgccg ccctacctga ggccgccatc cacgccggtt     2640

gagtcgcgtt ctgccgcctc ccgcctgtgg tgcctcctga actgcgtccg ccgtctaggt     2700

aagtttaaag ctcaggtcga gaccgggcct ttgtccggcg ctcccttgga gcctacctag     2760

actcagccgg ctctccacgc tttgcctgac cctgcttgct caactctacg tctttgtttc     2820

gttttctgtt ctgcgccgtt acagatccaa gctgtgaccg gcgcctacga tatggccaag     2880

cctttgtctc aagaagaatc caccctcatt gaaagagcaa cggctacaat caacagcatc     2940

cccatctctg aagactacag cgtcgccagc gcagctctct ctagcgacgg ccgcatcttc     3000

actggtgtca atgtatatca ttttactggg ggaccttgtg cagaactcgt ggtgctgggc     3060

actgctgctg ctgcggcagc tggcaacctg acttgtatcg tcgcgatcgg aaatgagaac     3120

aggggcatct tgagcccctg cggacggtgc cgacaggtgc ttctcgatct gcatcctggg     3180

atcaaagcca tagtgaagga cagtgatgga cagccgacgg cagttgggat tcgtgaattg     3240

ctgccctctg gttatgtgtg ggagggctaa caatcaacct ctggattaca aaatttgtga     3300

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     3360

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     3420

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     3480

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     3540

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     3600

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     3660

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     3720

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     3780

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     3840

cctttgggcc gcctccccgc ctggtacctt taagaccaat gacttacaag gcagctgtag     3900

atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa     3960

gataagatct gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg     4020

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     4080

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     4140

tttagtcagt gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt     4200

tataacttgc aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata     4260

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     4320

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat     4380

cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc     4440

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct     4500

attccagaag tagtgaggag gcttttttgg aggcctagac ttttgcagag accaaattcg     4560

taatcatgtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca     4620

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat     4680

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt     4740

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     4800

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     4860

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     4920

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     4980

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     5040

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     5100

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     5160

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     5220

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     5280

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     5340

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     5400

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     5460

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     5520

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     5580

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     5640

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     5700

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     5760

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     5820

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     5880

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     5940

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     6000

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     6060

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     6120

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     6180

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     6240

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     6300

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     6360

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     6420

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     6480

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     6540

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     6600

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     6660

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     6720

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     6780

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     6840

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     6900

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     6960

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     7020

tcaggcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct     7080

cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa     7140

cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgccaag ctg            7193


<210> 15
<211> 8159
<212> DNA
<213> Artificial Sequence


<220> 
<223> pCG1_SCoV2-S plasmid

<400> 15
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat cccccgatcc tgagaacttc agggtgagtt tggggaccct      660

tgattgttct ttctttttcg ctattgtaaa attcatgtta tatggagggg gcaaagtttt      720

cagggtgttg tttagaatgg gaagatgtcc cttgtatcac catggaccct catgataatt      780

ttgtttcttt cactttctac tctgttgaca accattgtct cctcttattt tcttttcatt      840

ttctgtaact ttttcgttaa actttagctt gcatttgtaa cgaattttta aattcacttt      900

tgtttatttg tcagattgta agtactttct ctaatcactt ttttttcaag gcaatcaggg      960

tatattatat tgtacttcag cacagtttta gagaacaatt gttataatta aatgataagg     1020

tagaatattt ctgcatataa attctggctg gcgtggaaat attcttattg gtagaaacaa     1080

ctacatcctg gtcatcatcc tgcctttctc tttatggtta caatgatata cactgtttga     1140

gatgaggata aaatactctg agtccaaacc gggcccctct gctaaccatg ttcatgcctt     1200

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     1260

caaagaattg taatacgact cactataggg cgaattcgga tccgccacca tgttcgtgtt     1320

tctggtgctg ctgcctctgg tgtccagcca gtgtgtgaac ctgaccacaa gaacccagct     1380

gcctccagcc tacaccaaca gctttaccag aggcgtgtac taccccgaca aggtgttcag     1440

atccagcgtg ctgcactcta cccaggacct gttcctgcct ttcttcagca acgtgacctg     1500

gttccacgcc atccacgtgt ccggcaccaa tggcaccaag agattcgaca accccgtgct     1560

gcccttcaac gacggggtgt actttgccag caccgagaag tccaacatca tcagaggctg     1620

gatcttcggc accacactgg acagcaagac ccagagcctg ctgatcgtga acaacgccac     1680

caacgtggtc atcaaagtgt gcgagttcca gttctgcaac gaccccttcc tgggcgtcta     1740

ctatcacaag aacaacaaga gctggatgga aagcgagttc cgggtgtaca gcagcgccaa     1800

caactgcacc ttcgagtacg tgtcccagcc tttcctgatg gacctggaag gcaagcaggg     1860

caacttcaag aacctgcgcg agttcgtgtt caagaacatc gacggctact tcaagatcta     1920

cagcaagcac acccctatca acctcgtgcg ggatctgcct cagggcttct ctgctctgga     1980

acccctggtg gatctgccca tcggcatcaa catcacccgg tttcagacac tgctggccct     2040

gcacagaagc tacctgacac ctggcgatag cagcagcgga tggacagctg gtgccgccgc     2100

ttactatgtg ggctacctgc agcctagaac cttcctgctg aagtacaacg agaacggcac     2160

catcaccgac gccgtggatt gtgcccttga tcctctgagc gagacaaagt gcaccctgaa     2220

gtccttcacc gtggaaaagg gcatctacca gaccagcaac ttccgggtgc agcccaccga     2280

atccatcgtg cggttcccca atatcaccaa tctgtgcccc ttcggcgagg tgttcaatgc     2340

caccagattc gcctctgtgt acgcctggaa ccggaagcgg atcagcaatt gcgtggccga     2400

ctactccgtg ctgtacaact ccgccagctt cagcaccttc aagtgctacg gcgtgtcccc     2460

taccaagctg aacgacctgt gcttcacaaa cgtgtacgcc gacagcttcg tgatccgggg     2520

agatgaagtg cggcagattg cccctggaca gacaggcaag atcgccgact acaactacaa     2580

gctgcccgac gacttcaccg gctgtgtgat tgcctggaac agcaacaacc tggactccaa     2640

agtcggcggc aactacaatt acctgtaccg gctgttccgg aagtccaatc tgaagccctt     2700

cgagcgggac atctccaccg agatctatca ggccggcagc accccttgta acggcgtgga     2760

aggcttcaac tgctacttcc cactgcagtc ctacggcttt cagcccacaa atggcgtggg     2820

ctatcagccc tacagagtgg tggtgctgag cttcgaactg ctgcatgccc ctgccacagt     2880

gtgcggccct aagaaaagca ccaatctcgt gaagaacaaa tgcgtgaact tcaacttcaa     2940

cggcctgacc ggcaccggcg tgctgacaga gagcaacaag aagttcctgc cattccagca     3000

gtttggccgg gatatcgccg ataccacaga cgccgttaga gatccccaga cactggaaat     3060

cctggacatc accccttgca gcttcggcgg agtgtctgtg atcacccctg gcaccaacac     3120

cagcaatcag gtggcagtgc tgtaccagga cgtgaactgt accgaagtgc ccgtggccat     3180

tcacgccgat cagctgacac ctacatggcg ggtgtactcc accggcagca atgtgtttca     3240

gaccagagcc ggctgtctga tcggagccga gcacgtgaac aatagctacg agtgcgacat     3300

ccccatcggc gctggcatct gtgccagcta ccagacacag acaaacagcc ccagacgggc     3360

cagatctgtg gccagccaga gcatcattgc ctacacaatg tctctgggcg ccgagaacag     3420

cgtggcctac tccaacaact ctatcgctat ccccaccaac ttcaccatca gcgtgaccac     3480

agagatcctg cctgtgtcca tgaccaagac cagcgtggac tgcaccatgt acatctgcgg     3540

cgattccacc gagtgctcca acctgctgct gcagtacggc agcttctgca cccagctgaa     3600

tagagccctg acagggatcg ccgtggaaca ggacaagaac acccaagagg tgttcgccca     3660

agtgaagcag atctacaaga cccctcctat caaggacttc ggcggcttca atttcagcca     3720

gattctgccc gatcctagca agcccagcaa gcggagcttc atcgaggacc tgctgttcaa     3780

caaagtgaca ctggccgacg ccggcttcat caagcagtat ggcgattgtc tgggcgacat     3840

tgccgccagg gatctgattt gcgcccagaa gtttaacgga ctgacagtgc tgccaccact     3900

gctgaccgat gagatgatcg cccagtacac atctgccctg ctggccggca caatcacaag     3960

cggctggaca tttggagctg gcgccgctct gcagatcccc tttgctatgc agatggccta     4020

ccggttcaac ggcatcggag tgacccagaa tgtgctgtac gagaaccaga agctgatcgc     4080

caaccagttc aacagcgcca tcggcaagat ccaggacagc ctgagcagca cagcaagcgc     4140

cctgggaaag ctgcaggacg tggtcaacca gaatgcccag gcactgaaca ccctggtcaa     4200

gcagctgtcc tccaacttcg gcgccatcag ctctgtgctg aacgatatcc tgagcagact     4260

ggacaaggtg gaagccgagg tgcagatcga cagactgatc accggaaggc tgcagtccct     4320

gcagacctac gttacccagc agctgatcag agccgccgag attagagcct ctgccaatct     4380

ggccgccacc aagatgtctg agtgtgtgct gggccagagc aagagagtgg acttttgcgg     4440

caagggctac cacctgatga gcttccctca gtctgcccct cacggcgtgg tgtttctgca     4500

cgtgacatac gtgcccgctc aagagaagaa tttcaccacc gctccagcca tctgccacga     4560

cggcaaagcc cactttccta gagaaggcgt gttcgtgtcc aacggcaccc attggttcgt     4620

gacccagcgg aacttctacg agccccagat catcaccacc gacaacacct tcgtgtctgg     4680

caactgcgac gtcgtgatcg gcattgtgaa caataccgtg tacgaccctc tgcagcccga     4740

gctggacagc ttcaaagagg aactggataa gtactttaag aaccacacaa gccccgacgt     4800

ggacctgggc gatatcagcg gaatcaatgc cagcgtcgtg aacatccaga aagagatcga     4860

ccggctgaac gaggtggcca agaatctgaa cgagagcctg atcgacctgc aagaactggg     4920

gaagtacgag cagtacatca agtggccctg gtacatctgg ctgggcttta tcgccggact     4980

gattgccatc gtgatggtca caatcatgct gtgttgcatg accagctgct gtagctgcct     5040

gaagggctgt tgtagctgtg gcagctgctg caagttcgac gaggacgatt ctgagcccgt     5100

gctgaagggc gtgaaactgc actacaccta atctagagtc gactgtttaa acctgcaggc     5160

atgcaagctg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     5220

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     5280

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag     5340

tatttggttt agagtttggc aacatatgcc atatgctggc tgccatgaac aaaggtggct     5400

ataaagaggt catcagtata tgaaacagcc ccctgctgtc cattccttat tccatagaaa     5460

agccttgact tgaggttaga ttttttttat attttgtttt gtgttatttt tttctttaac     5520

atccctaaaa ttttccttac atgttttact agccagattt ttcctcctct cctgactact     5580

cccagtcata gctgtccctc ttctcttatg aactcgagga gctttttgca aaagcctagg     5640

cctccaaaaa agcctcctca ctacttctgg aatagctcag aggccgaggc ggcctcggcc     5700

tctgcataaa taaaaaaaat tagtcagcca tggggcggag aatgggcgga actgggcgga     5760

gttaggggcg ggatgggcgg agttaggggc gggactatgg ttgctgacta attgagactg     5820

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     5880

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     5940

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     6000

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     6060

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     6120

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     6180

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     6240

ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     6300

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     6360

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     6420

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     6480

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     6540

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     6600

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     6660

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     6720

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     6780

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     6840

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     6900

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     6960

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     7020

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     7080

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     7140

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     7200

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     7260

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     7320

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     7380

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     7440

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     7500

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     7560

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     7620

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     7680

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     7740

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaacgtctt     7800

caagctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     7860

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     7920

cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag     7980

ttggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tcgacgctct     8040

cccttatgcg actcctgcat taggaagcag cccagtagta ggttgaggcc gttgagcacc     8100

gccgccgcaa ggaatggtgc tggcttatcg aaattaatcg actcactata gggagaccc      8159


<210> 16
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> G614 Spike primer 1

<400> 16
gcgtgaactg taccgaagtg                                                20


<210> 17
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> G614 Spike primer 2

<400> 17
cctggtacag cactgcc                                                   17


<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated SARS-CoV2-Spike primer 1

<400> 18
agcgaattcg gatccgcc                                                  18


<210> 19
<211> 34
<212> DNA
<213> Artificial Sequence


<220> 
<223> truncated SARS-CoV2-Spike primer 2

<400> 19
acagtcgact ctagattagc agcagctgcc acag                                 34


<210> 20
<211> 8159
<212> DNA
<213> Artificial Sequence


<220> 
<223> plasmids encoding Spike G614 Full length (FL)

<400> 20
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat cccccgatcc tgagaacttc agggtgagtt tggggaccct      660

tgattgttct ttctttttcg ctattgtaaa attcatgtta tatggagggg gcaaagtttt      720

cagggtgttg tttagaatgg gaagatgtcc cttgtatcac catggaccct catgataatt      780

ttgtttcttt cactttctac tctgttgaca accattgtct cctcttattt tcttttcatt      840

ttctgtaact ttttcgttaa actttagctt gcatttgtaa cgaattttta aattcacttt      900

tgtttatttg tcagattgta agtactttct ctaatcactt ttttttcaag gcaatcaggg      960

tatattatat tgtacttcag cacagtttta gagaacaatt gttataatta aatgataagg     1020

tagaatattt ctgcatataa attctggctg gcgtggaaat attcttattg gtagaaacaa     1080

ctacatcctg gtcatcatcc tgcctttctc tttatggtta caatgatata cactgtttga     1140

gatgaggata aaatactctg agtccaaacc gggcccctct gctaaccatg ttcatgcctt     1200

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     1260

caaagaattg taatacgact cactataggg cgaattcgga tccgccacca tgttcgtgtt     1320

tctggtgctg ctgcctctgg tgtccagcca gtgtgtgaac ctgaccacaa gaacccagct     1380

gcctccagcc tacaccaaca gctttaccag aggcgtgtac taccccgaca aggtgttcag     1440

atccagcgtg ctgcactcta cccaggacct gttcctgcct ttcttcagca acgtgacctg     1500

gttccacgcc atccacgtgt ccggcaccaa tggcaccaag agattcgaca accccgtgct     1560

gcccttcaac gacggggtgt actttgccag caccgagaag tccaacatca tcagaggctg     1620

gatcttcggc accacactgg acagcaagac ccagagcctg ctgatcgtga acaacgccac     1680

caacgtggtc atcaaagtgt gcgagttcca gttctgcaac gaccccttcc tgggcgtcta     1740

ctatcacaag aacaacaaga gctggatgga aagcgagttc cgggtgtaca gcagcgccaa     1800

caactgcacc ttcgagtacg tgtcccagcc tttcctgatg gacctggaag gcaagcaggg     1860

caacttcaag aacctgcgcg agttcgtgtt caagaacatc gacggctact tcaagatcta     1920

cagcaagcac acccctatca acctcgtgcg ggatctgcct cagggcttct ctgctctgga     1980

acccctggtg gatctgccca tcggcatcaa catcacccgg tttcagacac tgctggccct     2040

gcacagaagc tacctgacac ctggcgatag cagcagcgga tggacagctg gtgccgccgc     2100

ttactatgtg ggctacctgc agcctagaac cttcctgctg aagtacaacg agaacggcac     2160

catcaccgac gccgtggatt gtgcccttga tcctctgagc gagacaaagt gcaccctgaa     2220

gtccttcacc gtggaaaagg gcatctacca gaccagcaac ttccgggtgc agcccaccga     2280

atccatcgtg cggttcccca atatcaccaa tctgtgcccc ttcggcgagg tgttcaatgc     2340

caccagattc gcctctgtgt acgcctggaa ccggaagcgg atcagcaatt gcgtggccga     2400

ctactccgtg ctgtacaact ccgccagctt cagcaccttc aagtgctacg gcgtgtcccc     2460

taccaagctg aacgacctgt gcttcacaaa cgtgtacgcc gacagcttcg tgatccgggg     2520

agatgaagtg cggcagattg cccctggaca gacaggcaag atcgccgact acaactacaa     2580

gctgcccgac gacttcaccg gctgtgtgat tgcctggaac agcaacaacc tggactccaa     2640

agtcggcggc aactacaatt acctgtaccg gctgttccgg aagtccaatc tgaagccctt     2700

cgagcgggac atctccaccg agatctatca ggccggcagc accccttgta acggcgtgga     2760

aggcttcaac tgctacttcc cactgcagtc ctacggcttt cagcccacaa atggcgtggg     2820

ctatcagccc tacagagtgg tggtgctgag cttcgaactg ctgcatgccc ctgccacagt     2880

gtgcggccct aagaaaagca ccaatctcgt gaagaacaaa tgcgtgaact tcaacttcaa     2940

cggcctgacc ggcaccggcg tgctgacaga gagcaacaag aagttcctgc cattccagca     3000

gtttggccgg gatatcgccg ataccacaga cgccgttaga gatccccaga cactggaaat     3060

cctggacatc accccttgca gcttcggcgg agtgtctgtg atcacccctg gcaccaacac     3120

cagcaatcag gtggcagtgc tgtaccaggg cgtgaactgt accgaagtgc ccgtggccat     3180

tcacgccgat cagctgacac ctacatggcg ggtgtactcc accggcagca atgtgtttca     3240

gaccagagcc ggctgtctga tcggagccga gcacgtgaac aatagctacg agtgcgacat     3300

ccccatcggc gctggcatct gtgccagcta ccagacacag acaaacagcc ccagacgggc     3360

cagatctgtg gccagccaga gcatcattgc ctacacaatg tctctgggcg ccgagaacag     3420

cgtggcctac tccaacaact ctatcgctat ccccaccaac ttcaccatca gcgtgaccac     3480

agagatcctg cctgtgtcca tgaccaagac cagcgtggac tgcaccatgt acatctgcgg     3540

cgattccacc gagtgctcca acctgctgct gcagtacggc agcttctgca cccagctgaa     3600

tagagccctg acagggatcg ccgtggaaca ggacaagaac acccaagagg tgttcgccca     3660

agtgaagcag atctacaaga cccctcctat caaggacttc ggcggcttca atttcagcca     3720

gattctgccc gatcctagca agcccagcaa gcggagcttc atcgaggacc tgctgttcaa     3780

caaagtgaca ctggccgacg ccggcttcat caagcagtat ggcgattgtc tgggcgacat     3840

tgccgccagg gatctgattt gcgcccagaa gtttaacgga ctgacagtgc tgccaccact     3900

gctgaccgat gagatgatcg cccagtacac atctgccctg ctggccggca caatcacaag     3960

cggctggaca tttggagctg gcgccgctct gcagatcccc tttgctatgc agatggccta     4020

ccggttcaac ggcatcggag tgacccagaa tgtgctgtac gagaaccaga agctgatcgc     4080

caaccagttc aacagcgcca tcggcaagat ccaggacagc ctgagcagca cagcaagcgc     4140

cctgggaaag ctgcaggacg tggtcaacca gaatgcccag gcactgaaca ccctggtcaa     4200

gcagctgtcc tccaacttcg gcgccatcag ctctgtgctg aacgatatcc tgagcagact     4260

ggacaaggtg gaagccgagg tgcagatcga cagactgatc accggaaggc tgcagtccct     4320

gcagacctac gttacccagc agctgatcag agccgccgag attagagcct ctgccaatct     4380

ggccgccacc aagatgtctg agtgtgtgct gggccagagc aagagagtgg acttttgcgg     4440

caagggctac cacctgatga gcttccctca gtctgcccct cacggcgtgg tgtttctgca     4500

cgtgacatac gtgcccgctc aagagaagaa tttcaccacc gctccagcca tctgccacga     4560

cggcaaagcc cactttccta gagaaggcgt gttcgtgtcc aacggcaccc attggttcgt     4620

gacccagcgg aacttctacg agccccagat catcaccacc gacaacacct tcgtgtctgg     4680

caactgcgac gtcgtgatcg gcattgtgaa caataccgtg tacgaccctc tgcagcccga     4740

gctggacagc ttcaaagagg aactggataa gtactttaag aaccacacaa gccccgacgt     4800

ggacctgggc gatatcagcg gaatcaatgc cagcgtcgtg aacatccaga aagagatcga     4860

ccggctgaac gaggtggcca agaatctgaa cgagagcctg atcgacctgc aagaactggg     4920

gaagtacgag cagtacatca agtggccctg gtacatctgg ctgggcttta tcgccggact     4980

gattgccatc gtgatggtca caatcatgct gtgttgcatg accagctgct gtagctgcct     5040

gaagggctgt tgtagctgtg gcagctgctg caagttcgac gaggacgatt ctgagcccgt     5100

gctgaagggc gtgaaactgc actacaccta atctagagtc gactgtttaa acctgcaggc     5160

atgcaagctg atctttttcc ctctgccaaa aattatgggg acatcatgaa gccccttgag     5220

catctgactt ctggctaata aaggaaattt attttcattg caatagtgtg ttggaatttt     5280

ttgtgtctct cactcggaag gacatatggg agggcaaatc atttaaaaca tcagaatgag     5340

tatttggttt agagtttggc aacatatgcc atatgctggc tgccatgaac aaaggtggct     5400

ataaagaggt catcagtata tgaaacagcc ccctgctgtc cattccttat tccatagaaa     5460

agccttgact tgaggttaga ttttttttat attttgtttt gtgttatttt tttctttaac     5520

atccctaaaa ttttccttac atgttttact agccagattt ttcctcctct cctgactact     5580

cccagtcata gctgtccctc ttctcttatg aactcgagga gctttttgca aaagcctagg     5640

cctccaaaaa agcctcctca ctacttctgg aatagctcag aggccgaggc ggcctcggcc     5700

tctgcataaa taaaaaaaat tagtcagcca tggggcggag aatgggcgga actgggcgga     5760

gttaggggcg ggatgggcgg agttaggggc gggactatgg ttgctgacta attgagactg     5820

cattaatgaa tcggccaacg cgcggggaga ggcggtttgc gtattgggcg ctcttccgct     5880

tcctcgctca ctgactcgct gcgctcggtc gttcggctgc ggcgagcggt atcagctcac     5940

tcaaaggcgg taatacggtt atccacagaa tcaggggata acgcaggaaa gaacatgtga     6000

gcaaaaggcc agcaaaaggc caggaaccgt aaaaaggccg cgttgctggc gtttttccat     6060

aggctccgcc cccctgacga gcatcacaaa aatcgacgct caagtcagag gtggcgaaac     6120

ccgacaggac tataaagata ccaggcgttt ccccctggaa gctccctcgt gcgctctcct     6180

gttccgaccc tgccgcttac cggatacctg tccgcctttc tcccttcggg aagcgtggcg     6240

ctttctcaat gctcacgctg taggtatctc agttcggtgt aggtcgttcg ctccaagctg     6300

ggctgtgtgc acgaaccccc cgttcagccc gaccgctgcg ccttatccgg taactatcgt     6360

cttgagtcca acccggtaag acacgactta tcgccactgg cagcagccac tggtaacagg     6420

attagcagag cgaggtatgt aggcggtgct acagagttct tgaagtggtg gcctaactac     6480

ggctacacta gaaggacagt atttggtatc tgcgctctgc tgaagccagt taccttcgga     6540

aaaagagttg gtagctcttg atccggcaaa caaaccaccg ctggtagcgg tggttttttt     6600

gtttgcaagc agcagattac gcgcagaaaa aaaggatctc aagaagatcc tttgatcttt     6660

tctacggggt ctgacgctca gtggaacgaa aactcacgtt aagggatttt ggtcatgaga     6720

ttatcaaaaa ggatcttcac ctagatcctt ttaaattaaa aatgaagttt taaatcaatc     6780

taaagtatat atgagtaaac ttggtctgac agttaccaat gcttaatcag tgaggcacct     6840

atctcagcga tctgtctatt tcgttcatcc atagttgcct gactccccgt cgtgtagata     6900

actacgatac gggagggctt accatctggc cccagtgctg caatgatacc gcgagaccca     6960

cgctcaccgg ctccagattt atcagcaata aaccagccag ccggaagggc cgagcgcaga     7020

agtggtcctg caactttatc cgcctccatc cagtctatta attgttgccg ggaagctaga     7080

gtaagtagtt cgccagttaa tagtttgcgc aacgttgttg ccattgctac aggcatcgtg     7140

gtgtcacgct cgtcgtttgg tatggcttca ttcagctccg gttcccaacg atcaaggcga     7200

gttacatgat cccccatgtt gtgcaaaaaa gcggttagct ccttcggtcc tccgatcgtt     7260

gtcagaagta agttggccgc agtgttatca ctcatggtta tggcagcact gcataattct     7320

cttactgtca tgccatccgt aagatgcttt tctgtgactg gtgagtactc aaccaagtca     7380

ttctgagaat agtgtatgcg gcgaccgagt tgctcttgcc cggcgtcaat acgggataat     7440

accgcgccac atagcagaac tttaaaagtg ctcatcattg gaaaacgttc ttcggggcga     7500

aaactctcaa ggatcttacc gctgttgaga tccagttcga tgtaacccac tcgtgcaccc     7560

aactgatctt cagcatcttt tactttcacc agcgtttctg ggtgagcaaa aacaggaagg     7620

caaaatgccg caaaaaaggg aataagggcg acacggaaat gttgaatact catactcttc     7680

ctttttcaat attattgaag catttatcag ggttattgtc tcatgagcgg atacatattt     7740

gaatgtattt agaaaaataa acaaataggg gttccgcgca catttccccg aaaacgtctt     7800

caagctgcct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     7860

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     7920

cagcgggtgt tggcgggtgt cggggcgcag ccatgaccca gtcacgtagc gatagcggag     7980

ttggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tcgacgctct     8040

cccttatgcg actcctgcat taggaagcag cccagtagta ggttgaggcc gttgagcacc     8100

gccgccgcaa ggaatggtgc tggcttatcg aaattaatcg actcactata gggagaccc      8159


<210> 21
<211> 8102
<212> DNA
<213> Artificial Sequence


<220> 
<223> plasmids encoding Spike D614 DeltaCter

<400> 21
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat cccccgatcc tgagaacttc agggtgagtt tggggaccct      660

tgattgttct ttctttttcg ctattgtaaa attcatgtta tatggagggg gcaaagtttt      720

cagggtgttg tttagaatgg gaagatgtcc cttgtatcac catggaccct catgataatt      780

ttgtttcttt cactttctac tctgttgaca accattgtct cctcttattt tcttttcatt      840

ttctgtaact ttttcgttaa actttagctt gcatttgtaa cgaattttta aattcacttt      900

tgtttatttg tcagattgta agtactttct ctaatcactt ttttttcaag gcaatcaggg      960

tatattatat tgtacttcag cacagtttta gagaacaatt gttataatta aatgataagg     1020

tagaatattt ctgcatataa attctggctg gcgtggaaat attcttattg gtagaaacaa     1080

ctacatcctg gtcatcatcc tgcctttctc tttatggtta caatgatata cactgtttga     1140

gatgaggata aaatactctg agtccaaacc gggcccctct gctaaccatg ttcatgcctt     1200

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     1260

caaagaattg taatacgact cactataggg cgaattcgga tccgccacca tgttcgtgtt     1320

tctggtgctg ctgcctctgg tgtccagcca gtgtgtgaac ctgaccacaa gaacccagct     1380

gcctccagcc tacaccaaca gctttaccag aggcgtgtac taccccgaca aggtgttcag     1440

atccagcgtg ctgcactcta cccaggacct gttcctgcct ttcttcagca acgtgacctg     1500

gttccacgcc atccacgtgt ccggcaccaa tggcaccaag agattcgaca accccgtgct     1560

gcccttcaac gacggggtgt actttgccag caccgagaag tccaacatca tcagaggctg     1620

gatcttcggc accacactgg acagcaagac ccagagcctg ctgatcgtga acaacgccac     1680

caacgtggtc atcaaagtgt gcgagttcca gttctgcaac gaccccttcc tgggcgtcta     1740

ctatcacaag aacaacaaga gctggatgga aagcgagttc cgggtgtaca gcagcgccaa     1800

caactgcacc ttcgagtacg tgtcccagcc tttcctgatg gacctggaag gcaagcaggg     1860

caacttcaag aacctgcgcg agttcgtgtt caagaacatc gacggctact tcaagatcta     1920

cagcaagcac acccctatca acctcgtgcg ggatctgcct cagggcttct ctgctctgga     1980

acccctggtg gatctgccca tcggcatcaa catcacccgg tttcagacac tgctggccct     2040

gcacagaagc tacctgacac ctggcgatag cagcagcgga tggacagctg gtgccgccgc     2100

ttactatgtg ggctacctgc agcctagaac cttcctgctg aagtacaacg agaacggcac     2160

catcaccgac gccgtggatt gtgcccttga tcctctgagc gagacaaagt gcaccctgaa     2220

gtccttcacc gtggaaaagg gcatctacca gaccagcaac ttccgggtgc agcccaccga     2280

atccatcgtg cggttcccca atatcaccaa tctgtgcccc ttcggcgagg tgttcaatgc     2340

caccagattc gcctctgtgt acgcctggaa ccggaagcgg atcagcaatt gcgtggccga     2400

ctactccgtg ctgtacaact ccgccagctt cagcaccttc aagtgctacg gcgtgtcccc     2460

taccaagctg aacgacctgt gcttcacaaa cgtgtacgcc gacagcttcg tgatccgggg     2520

agatgaagtg cggcagattg cccctggaca gacaggcaag atcgccgact acaactacaa     2580

gctgcccgac gacttcaccg gctgtgtgat tgcctggaac agcaacaacc tggactccaa     2640

agtcggcggc aactacaatt acctgtaccg gctgttccgg aagtccaatc tgaagccctt     2700

cgagcgggac atctccaccg agatctatca ggccggcagc accccttgta acggcgtgga     2760

aggcttcaac tgctacttcc cactgcagtc ctacggcttt cagcccacaa atggcgtggg     2820

ctatcagccc tacagagtgg tggtgctgag cttcgaactg ctgcatgccc ctgccacagt     2880

gtgcggccct aagaaaagca ccaatctcgt gaagaacaaa tgcgtgaact tcaacttcaa     2940

cggcctgacc ggcaccggcg tgctgacaga gagcaacaag aagttcctgc cattccagca     3000

gtttggccgg gatatcgccg ataccacaga cgccgttaga gatccccaga cactggaaat     3060

cctggacatc accccttgca gcttcggcgg agtgtctgtg atcacccctg gcaccaacac     3120

cagcaatcag gtggcagtgc tgtaccagga cgtgaactgt accgaagtgc ccgtggccat     3180

tcacgccgat cagctgacac ctacatggcg ggtgtactcc accggcagca atgtgtttca     3240

gaccagagcc ggctgtctga tcggagccga gcacgtgaac aatagctacg agtgcgacat     3300

ccccatcggc gctggcatct gtgccagcta ccagacacag acaaacagcc ccagacgggc     3360

cagatctgtg gccagccaga gcatcattgc ctacacaatg tctctgggcg ccgagaacag     3420

cgtggcctac tccaacaact ctatcgctat ccccaccaac ttcaccatca gcgtgaccac     3480

agagatcctg cctgtgtcca tgaccaagac cagcgtggac tgcaccatgt acatctgcgg     3540

cgattccacc gagtgctcca acctgctgct gcagtacggc agcttctgca cccagctgaa     3600

tagagccctg acagggatcg ccgtggaaca ggacaagaac acccaagagg tgttcgccca     3660

agtgaagcag atctacaaga cccctcctat caaggacttc ggcggcttca atttcagcca     3720

gattctgccc gatcctagca agcccagcaa gcggagcttc atcgaggacc tgctgttcaa     3780

caaagtgaca ctggccgacg ccggcttcat caagcagtat ggcgattgtc tgggcgacat     3840

tgccgccagg gatctgattt gcgcccagaa gtttaacgga ctgacagtgc tgccaccact     3900

gctgaccgat gagatgatcg cccagtacac atctgccctg ctggccggca caatcacaag     3960

cggctggaca tttggagctg gcgccgctct gcagatcccc tttgctatgc agatggccta     4020

ccggttcaac ggcatcggag tgacccagaa tgtgctgtac gagaaccaga agctgatcgc     4080

caaccagttc aacagcgcca tcggcaagat ccaggacagc ctgagcagca cagcaagcgc     4140

cctgggaaag ctgcaggacg tggtcaacca gaatgcccag gcactgaaca ccctggtcaa     4200

gcagctgtcc tccaacttcg gcgccatcag ctctgtgctg aacgatatcc tgagcagact     4260

ggacaaggtg gaagccgagg tgcagatcga cagactgatc accggaaggc tgcagtccct     4320

gcagacctac gttacccagc agctgatcag agccgccgag attagagcct ctgccaatct     4380

ggccgccacc aagatgtctg agtgtgtgct gggccagagc aagagagtgg acttttgcgg     4440

caagggctac cacctgatga gcttccctca gtctgcccct cacggcgtgg tgtttctgca     4500

cgtgacatac gtgcccgctc aagagaagaa tttcaccacc gctccagcca tctgccacga     4560

cggcaaagcc cactttccta gagaaggcgt gttcgtgtcc aacggcaccc attggttcgt     4620

gacccagcgg aacttctacg agccccagat catcaccacc gacaacacct tcgtgtctgg     4680

caactgcgac gtcgtgatcg gcattgtgaa caataccgtg tacgaccctc tgcagcccga     4740

gctggacagc ttcaaagagg aactggataa gtactttaag aaccacacaa gccccgacgt     4800

ggacctgggc gatatcagcg gaatcaatgc cagcgtcgtg aacatccaga aagagatcga     4860

ccggctgaac gaggtggcca agaatctgaa cgagagcctg atcgacctgc aagaactggg     4920

gaagtacgag cagtacatca agtggccctg gtacatctgg ctgggcttta tcgccggact     4980

gattgccatc gtgatggtca caatcatgct gtgttgcatg accagctgct gtagctgcct     5040

gaagggctgt tgtagctgtg gcagctgctg ctaatctaga gtcgactgtt taaacctgca     5100

ggcatgcaag ctgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt     5160

gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat     5220

tttttgtgtc tctcactcgg aaggacatat gggagggcaa atcatttaaa acatcagaat     5280

gagtatttgg tttagagttt ggcaacatat gccatatgct ggctgccatg aacaaaggtg     5340

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     5400

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     5460

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     5520

actcccagtc atagctgtcc ctcttctctt atgaactcga ggagcttttt gcaaaagcct     5580

aggcctccaa aaaagcctcc tcactacttc tggaatagct cagaggccga ggcggcctcg     5640

gcctctgcat aaataaaaaa aattagtcag ccatggggcg gagaatgggc ggaactgggc     5700

ggagttaggg gcgggatggg cggagttagg ggcgggacta tggttgctga ctaattgaga     5760

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     5820

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     5880

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     5940

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     6000

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     6060

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     6120

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     6180

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     6240

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     6300

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     6360

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     6420

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     6480

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     6540

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     6600

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     6660

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     6720

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     6780

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     6840

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     6900

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     6960

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     7020

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     7080

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     7140

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     7200

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     7260

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     7320

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     7380

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     7440

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     7500

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     7560

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     7620

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     7680

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaacgt     7740

cttcaagctg cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc     7800

cggagacggt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg     7860

cgtcagcggg tgttggcggg tgtcggggcg cagccatgac ccagtcacgt agcgatagcg     7920

gagttggctt aactatgcgg catcagagca gattgtactg agagtgcacc atatcgacgc     7980

tctcccttat gcgactcctg cattaggaag cagcccagta gtaggttgag gccgttgagc     8040

accgccgccg caaggaatgg tgctggctta tcgaaattaa tcgactcact atagggagac     8100

cc                                                                    8102


<210> 22
<211> 8102
<212> DNA
<213> Artificial Sequence


<220> 
<223> plasmids Spike G614 DeltaCter

<400> 22
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat cccccgatcc tgagaacttc agggtgagtt tggggaccct      660

tgattgttct ttctttttcg ctattgtaaa attcatgtta tatggagggg gcaaagtttt      720

cagggtgttg tttagaatgg gaagatgtcc cttgtatcac catggaccct catgataatt      780

ttgtttcttt cactttctac tctgttgaca accattgtct cctcttattt tcttttcatt      840

ttctgtaact ttttcgttaa actttagctt gcatttgtaa cgaattttta aattcacttt      900

tgtttatttg tcagattgta agtactttct ctaatcactt ttttttcaag gcaatcaggg      960

tatattatat tgtacttcag cacagtttta gagaacaatt gttataatta aatgataagg     1020

tagaatattt ctgcatataa attctggctg gcgtggaaat attcttattg gtagaaacaa     1080

ctacatcctg gtcatcatcc tgcctttctc tttatggtta caatgatata cactgtttga     1140

gatgaggata aaatactctg agtccaaacc gggcccctct gctaaccatg ttcatgcctt     1200

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     1260

caaagaattg taatacgact cactataggg cgaattcgga tccgccacca tgttcgtgtt     1320

tctggtgctg ctgcctctgg tgtccagcca gtgtgtgaac ctgaccacaa gaacccagct     1380

gcctccagcc tacaccaaca gctttaccag aggcgtgtac taccccgaca aggtgttcag     1440

atccagcgtg ctgcactcta cccaggacct gttcctgcct ttcttcagca acgtgacctg     1500

gttccacgcc atccacgtgt ccggcaccaa tggcaccaag agattcgaca accccgtgct     1560

gcccttcaac gacggggtgt actttgccag caccgagaag tccaacatca tcagaggctg     1620

gatcttcggc accacactgg acagcaagac ccagagcctg ctgatcgtga acaacgccac     1680

caacgtggtc atcaaagtgt gcgagttcca gttctgcaac gaccccttcc tgggcgtcta     1740

ctatcacaag aacaacaaga gctggatgga aagcgagttc cgggtgtaca gcagcgccaa     1800

caactgcacc ttcgagtacg tgtcccagcc tttcctgatg gacctggaag gcaagcaggg     1860

caacttcaag aacctgcgcg agttcgtgtt caagaacatc gacggctact tcaagatcta     1920

cagcaagcac acccctatca acctcgtgcg ggatctgcct cagggcttct ctgctctgga     1980

acccctggtg gatctgccca tcggcatcaa catcacccgg tttcagacac tgctggccct     2040

gcacagaagc tacctgacac ctggcgatag cagcagcgga tggacagctg gtgccgccgc     2100

ttactatgtg ggctacctgc agcctagaac cttcctgctg aagtacaacg agaacggcac     2160

catcaccgac gccgtggatt gtgcccttga tcctctgagc gagacaaagt gcaccctgaa     2220

gtccttcacc gtggaaaagg gcatctacca gaccagcaac ttccgggtgc agcccaccga     2280

atccatcgtg cggttcccca atatcaccaa tctgtgcccc ttcggcgagg tgttcaatgc     2340

caccagattc gcctctgtgt acgcctggaa ccggaagcgg atcagcaatt gcgtggccga     2400

ctactccgtg ctgtacaact ccgccagctt cagcaccttc aagtgctacg gcgtgtcccc     2460

taccaagctg aacgacctgt gcttcacaaa cgtgtacgcc gacagcttcg tgatccgggg     2520

agatgaagtg cggcagattg cccctggaca gacaggcaag atcgccgact acaactacaa     2580

gctgcccgac gacttcaccg gctgtgtgat tgcctggaac agcaacaacc tggactccaa     2640

agtcggcggc aactacaatt acctgtaccg gctgttccgg aagtccaatc tgaagccctt     2700

cgagcgggac atctccaccg agatctatca ggccggcagc accccttgta acggcgtgga     2760

aggcttcaac tgctacttcc cactgcagtc ctacggcttt cagcccacaa atggcgtggg     2820

ctatcagccc tacagagtgg tggtgctgag cttcgaactg ctgcatgccc ctgccacagt     2880

gtgcggccct aagaaaagca ccaatctcgt gaagaacaaa tgcgtgaact tcaacttcaa     2940

cggcctgacc ggcaccggcg tgctgacaga gagcaacaag aagttcctgc cattccagca     3000

gtttggccgg gatatcgccg ataccacaga cgccgttaga gatccccaga cactggaaat     3060

cctggacatc accccttgca gcttcggcgg agtgtctgtg atcacccctg gcaccaacac     3120

cagcaatcag gtggcagtgc tgtaccaggg cgtgaactgt accgaagtgc ccgtggccat     3180

tcacgccgat cagctgacac ctacatggcg ggtgtactcc accggcagca atgtgtttca     3240

gaccagagcc ggctgtctga tcggagccga gcacgtgaac aatagctacg agtgcgacat     3300

ccccatcggc gctggcatct gtgccagcta ccagacacag acaaacagcc ccagacgggc     3360

cagatctgtg gccagccaga gcatcattgc ctacacaatg tctctgggcg ccgagaacag     3420

cgtggcctac tccaacaact ctatcgctat ccccaccaac ttcaccatca gcgtgaccac     3480

agagatcctg cctgtgtcca tgaccaagac cagcgtggac tgcaccatgt acatctgcgg     3540

cgattccacc gagtgctcca acctgctgct gcagtacggc agcttctgca cccagctgaa     3600

tagagccctg acagggatcg ccgtggaaca ggacaagaac acccaagagg tgttcgccca     3660

agtgaagcag atctacaaga cccctcctat caaggacttc ggcggcttca atttcagcca     3720

gattctgccc gatcctagca agcccagcaa gcggagcttc atcgaggacc tgctgttcaa     3780

caaagtgaca ctggccgacg ccggcttcat caagcagtat ggcgattgtc tgggcgacat     3840

tgccgccagg gatctgattt gcgcccagaa gtttaacgga ctgacagtgc tgccaccact     3900

gctgaccgat gagatgatcg cccagtacac atctgccctg ctggccggca caatcacaag     3960

cggctggaca tttggagctg gcgccgctct gcagatcccc tttgctatgc agatggccta     4020

ccggttcaac ggcatcggag tgacccagaa tgtgctgtac gagaaccaga agctgatcgc     4080

caaccagttc aacagcgcca tcggcaagat ccaggacagc ctgagcagca cagcaagcgc     4140

cctgggaaag ctgcaggacg tggtcaacca gaatgcccag gcactgaaca ccctggtcaa     4200

gcagctgtcc tccaacttcg gcgccatcag ctctgtgctg aacgatatcc tgagcagact     4260

ggacaaggtg gaagccgagg tgcagatcga cagactgatc accggaaggc tgcagtccct     4320

gcagacctac gttacccagc agctgatcag agccgccgag attagagcct ctgccaatct     4380

ggccgccacc aagatgtctg agtgtgtgct gggccagagc aagagagtgg acttttgcgg     4440

caagggctac cacctgatga gcttccctca gtctgcccct cacggcgtgg tgtttctgca     4500

cgtgacatac gtgcccgctc aagagaagaa tttcaccacc gctccagcca tctgccacga     4560

cggcaaagcc cactttccta gagaaggcgt gttcgtgtcc aacggcaccc attggttcgt     4620

gacccagcgg aacttctacg agccccagat catcaccacc gacaacacct tcgtgtctgg     4680

caactgcgac gtcgtgatcg gcattgtgaa caataccgtg tacgaccctc tgcagcccga     4740

gctggacagc ttcaaagagg aactggataa gtactttaag aaccacacaa gccccgacgt     4800

ggacctgggc gatatcagcg gaatcaatgc cagcgtcgtg aacatccaga aagagatcga     4860

ccggctgaac gaggtggcca agaatctgaa cgagagcctg atcgacctgc aagaactggg     4920

gaagtacgag cagtacatca agtggccctg gtacatctgg ctgggcttta tcgccggact     4980

gattgccatc gtgatggtca caatcatgct gtgttgcatg accagctgct gtagctgcct     5040

gaagggctgt tgtagctgtg gcagctgctg ctaatctaga gtcgactgtt taaacctgca     5100

ggcatgcaag ctgatctttt tccctctgcc aaaaattatg gggacatcat gaagcccctt     5160

gagcatctga cttctggcta ataaaggaaa tttattttca ttgcaatagt gtgttggaat     5220

tttttgtgtc tctcactcgg aaggacatat gggagggcaa atcatttaaa acatcagaat     5280

gagtatttgg tttagagttt ggcaacatat gccatatgct ggctgccatg aacaaaggtg     5340

gctataaaga ggtcatcagt atatgaaaca gccccctgct gtccattcct tattccatag     5400

aaaagccttg acttgaggtt agattttttt tatattttgt tttgtgttat ttttttcttt     5460

aacatcccta aaattttcct tacatgtttt actagccaga tttttcctcc tctcctgact     5520

actcccagtc atagctgtcc ctcttctctt atgaactcga ggagcttttt gcaaaagcct     5580

aggcctccaa aaaagcctcc tcactacttc tggaatagct cagaggccga ggcggcctcg     5640

gcctctgcat aaataaaaaa aattagtcag ccatggggcg gagaatgggc ggaactgggc     5700

ggagttaggg gcgggatggg cggagttagg ggcgggacta tggttgctga ctaattgaga     5760

ctgcattaat gaatcggcca acgcgcgggg agaggcggtt tgcgtattgg gcgctcttcc     5820

gcttcctcgc tcactgactc gctgcgctcg gtcgttcggc tgcggcgagc ggtatcagct     5880

cactcaaagg cggtaatacg gttatccaca gaatcagggg ataacgcagg aaagaacatg     5940

tgagcaaaag gccagcaaaa ggccaggaac cgtaaaaagg ccgcgttgct ggcgtttttc     6000

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga     6060

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct     6120

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg     6180

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag     6240

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat     6300

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac     6360

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac     6420

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc     6480

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt     6540

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc     6600

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg     6660

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca     6720

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca     6780

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag     6840

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac     6900

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc     6960

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct     7020

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tacaggcatc     7080

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg     7140

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc     7200

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat     7260

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag     7320

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aatacgggat     7380

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg     7440

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca     7500

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga     7560

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc     7620

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata     7680

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaacgt     7740

cttcaagctg cctcgcgcgt ttcggtgatg acggtgaaaa cctctgacac atgcagctcc     7800

cggagacggt cacagcttgt ctgtaagcgg atgccgggag cagacaagcc cgtcagggcg     7860

cgtcagcggg tgttggcggg tgtcggggcg cagccatgac ccagtcacgt agcgatagcg     7920

gagttggctt aactatgcgg catcagagca gattgtactg agagtgcacc atatcgacgc     7980

tctcccttat gcgactcctg cattaggaag cagcccagta gtaggttgag gccgttgagc     8040

accgccgccg caaggaatgg tgctggctta tcgaaattaa tcgactcact atagggagac     8100

cc                                                                    8102


<210> 23
<211> 4337
<212> DNA
<213> Artificial Sequence


<220> 
<223> plasmids encoding empty vector

<400> 23
gaattcgagc tcgccccgtt acataactta cggtaaatgg cccgcctggc tgaccgccca       60

acgacccccg cccattgacg tcaataatga cgtatgttcc catagtaacg ccaataggga      120

ctttccattg acgtcaatgg gtggagtatt tacggtaaac tgcccacttg gcagtacatc      180

aagtgtatca tatgccaagt acgcccccta ttgacgtcaa tgacggtaaa tggcccgcct      240

ggcattatgc ccagtacatg accttatggg actttcctac ttggcagtac atctacgtat      300

tagtcatcgc tattaccatg gtgatgcggt tttggcagta catcaatggg cgtggatagc      360

ggtttgactc acggggattt ccaagtctcc accccattga cgtcaatggg agtttgtttt      420

ggcaccaaaa tcaacgggac tttccaaaat gtcgtaacaa ctccgcccca ttgacgcaaa      480

tgggcggtag gcgtgtacgg tgggaggtct atataagcag agctcgttta gtgaaccgtc      540

agatcgcctg gagacgccat ccacgctgtt ttgacctcca tagaagacac cgggaccgat      600

ccagcctccg ggggatcgat cccccgatcc tgagaacttc agggtgagtt tggggaccct      660

tgattgttct ttctttttcg ctattgtaaa attcatgtta tatggagggg gcaaagtttt      720

cagggtgttg tttagaatgg gaagatgtcc cttgtatcac catggaccct catgataatt      780

ttgtttcttt cactttctac tctgttgaca accattgtct cctcttattt tcttttcatt      840

ttctgtaact ttttcgttaa actttagctt gcatttgtaa cgaattttta aattcacttt      900

tgtttatttg tcagattgta agtactttct ctaatcactt ttttttcaag gcaatcaggg      960

tatattatat tgtacttcag cacagtttta gagaacaatt gttataatta aatgataagg     1020

tagaatattt ctgcatataa attctggctg gcgtggaaat attcttattg gtagaaacaa     1080

ctacatcctg gtcatcatcc tgcctttctc tttatggtta caatgatata cactgtttga     1140

gatgaggata aaatactctg agtccaaacc gggcccctct gctaaccatg ttcatgcctt     1200

cttctttttc ctacagctcc tgggcaacgt gctggttatt gtgctgtctc atcattttgg     1260

caaagaattg taatacgact cactataggg cgaattcgga tccgccacct ctagagtcga     1320

ctgtttaaac ctgcaggcat gcaagctgat ctttttccct ctgccaaaaa ttatggggac     1380

atcatgaagc cccttgagca tctgacttct ggctaataaa ggaaatttat tttcattgca     1440

atagtgtgtt ggaatttttt gtgtctctca ctcggaagga catatgggag ggcaaatcat     1500

ttaaaacatc agaatgagta tttggtttag agtttggcaa catatgccat atgctggctg     1560

ccatgaacaa aggtggctat aaagaggtca tcagtatatg aaacagcccc ctgctgtcca     1620

ttccttattc catagaaaag ccttgacttg aggttagatt ttttttatat tttgttttgt     1680

gttatttttt tctttaacat ccctaaaatt ttccttacat gttttactag ccagattttt     1740

cctcctctcc tgactactcc cagtcatagc tgtccctctt ctcttatgaa ctcgaggagc     1800

tttttgcaaa agcctaggcc tccaaaaaag cctcctcact acttctggaa tagctcagag     1860

gccgaggcgg cctcggcctc tgcataaata aaaaaaatta gtcagccatg gggcggagaa     1920

tgggcggaac tgggcggagt taggggcggg atgggcggag ttaggggcgg gactatggtt     1980

gctgactaat tgagactgca ttaatgaatc ggccaacgcg cggggagagg cggtttgcgt     2040

attgggcgct cttccgcttc ctcgctcact gactcgctgc gctcggtcgt tcggctgcgg     2100

cgagcggtat cagctcactc aaaggcggta atacggttat ccacagaatc aggggataac     2160

gcaggaaaga acatgtgagc aaaaggccag caaaaggcca ggaaccgtaa aaaggccgcg     2220

ttgctggcgt ttttccatag gctccgcccc cctgacgagc atcacaaaaa tcgacgctca     2280

agtcagaggt ggcgaaaccc gacaggacta taaagatacc aggcgtttcc ccctggaagc     2340

tccctcgtgc gctctcctgt tccgaccctg ccgcttaccg gatacctgtc cgcctttctc     2400

ccttcgggaa gcgtggcgct ttctcaatgc tcacgctgta ggtatctcag ttcggtgtag     2460

gtcgttcgct ccaagctggg ctgtgtgcac gaaccccccg ttcagcccga ccgctgcgcc     2520

ttatccggta actatcgtct tgagtccaac ccggtaagac acgacttatc gccactggca     2580

gcagccactg gtaacaggat tagcagagcg aggtatgtag gcggtgctac agagttcttg     2640

aagtggtggc ctaactacgg ctacactaga aggacagtat ttggtatctg cgctctgctg     2700

aagccagtta ccttcggaaa aagagttggt agctcttgat ccggcaaaca aaccaccgct     2760

ggtagcggtg gtttttttgt ttgcaagcag cagattacgc gcagaaaaaa aggatctcaa     2820

gaagatcctt tgatcttttc tacggggtct gacgctcagt ggaacgaaaa ctcacgttaa     2880

gggattttgg tcatgagatt atcaaaaagg atcttcacct agatcctttt aaattaaaaa     2940

tgaagtttta aatcaatcta aagtatatat gagtaaactt ggtctgacag ttaccaatgc     3000

ttaatcagtg aggcacctat ctcagcgatc tgtctatttc gttcatccat agttgcctga     3060

ctccccgtcg tgtagataac tacgatacgg gagggcttac catctggccc cagtgctgca     3120

atgataccgc gagacccacg ctcaccggct ccagatttat cagcaataaa ccagccagcc     3180

ggaagggccg agcgcagaag tggtcctgca actttatccg cctccatcca gtctattaat     3240

tgttgccggg aagctagagt aagtagttcg ccagttaata gtttgcgcaa cgttgttgcc     3300

attgctacag gcatcgtggt gtcacgctcg tcgtttggta tggcttcatt cagctccggt     3360

tcccaacgat caaggcgagt tacatgatcc cccatgttgt gcaaaaaagc ggttagctcc     3420

ttcggtcctc cgatcgttgt cagaagtaag ttggccgcag tgttatcact catggttatg     3480

gcagcactgc ataattctct tactgtcatg ccatccgtaa gatgcttttc tgtgactggt     3540

gagtactcaa ccaagtcatt ctgagaatag tgtatgcggc gaccgagttg ctcttgcccg     3600

gcgtcaatac gggataatac cgcgccacat agcagaactt taaaagtgct catcattgga     3660

aaacgttctt cggggcgaaa actctcaagg atcttaccgc tgttgagatc cagttcgatg     3720

taacccactc gtgcacccaa ctgatcttca gcatctttta ctttcaccag cgtttctggg     3780

tgagcaaaaa caggaaggca aaatgccgca aaaaagggaa taagggcgac acggaaatgt     3840

tgaatactca tactcttcct ttttcaatat tattgaagca tttatcaggg ttattgtctc     3900

atgagcggat acatatttga atgtatttag aaaaataaac aaataggggt tccgcgcaca     3960

tttccccgaa aacgtcttca agctgcctcg cgcgtttcgg tgatgacggt gaaaacctct     4020

gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac     4080

aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc atgacccagt     4140

cacgtagcga tagcggagtt ggcttaacta tgcggcatca gagcagattg tactgagagt     4200

gcaccatatc gacgctctcc cttatgcgac tcctgcatta ggaagcagcc cagtagtagg     4260

ttgaggccgt tgagcaccgc cgccgcaagg aatggtgctg gcttatcgaa attaatcgac     4320

tcactatagg gagaccc                                                    4337


<210> 24
<211> 9893
<212> DNA
<213> Artificial Sequence


<220> 
<223> Vector for ACE2 transduction

<400> 24
acgcgtgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca       60

acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta      120

cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga      180

attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc      240

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      300

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      360

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg      420

cccgaacagg gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct      480

tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt      540

gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag      600

aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt      660

aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt      720

agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg      780

atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag      840

gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag      900

taagaccacc gcacagcaag cggccactga tcttcagacc tggaggagga gatatgaggg      960

acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag     1020

cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag     1080

ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc     1140

tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga     1200

gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc     1260

aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg     1320

gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata     1380

aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca     1440

attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg     1500

aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa     1560

attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa     1620

tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt     1680

ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag     1740

gtggagagag agacagagac agatccattc gattagtgaa cggatctcga cggtatcggt     1800

taacttttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca     1860

taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa ttcaaaattt     1920

tatcgattac tagtattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2040

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2100

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2160

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtt tatataagca gagctcgttt     2220

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagatt     2280

ctagagctag cgtttaaact taagcttggt accgagctcg gatccactag tccagtgtgg     2340

tggaattctg cagatatcca gcacagtggc ggccgctcga gatgtcaagc tcttcctggc     2400

tccttctcag ccttgttgct gtaactgctg ctcagtccac cattgaggaa caggccaaga     2460

catttttgga caagtttaac cacgaagccg aagacctgtt ctatcaaagt tcacttgctt     2520

cttggaatta taacaccaat attactgaag agaatgtcca aaacatgaat aatgctgggg     2580

acaaatggtc tgccttttta aaggaacagt ccacacttgc ccaaatgtat ccactacaag     2640

aaattcagaa tctcacagtc aagcttcagc tgcaggctct tcagcaaaat gggtcttcag     2700

tgctctcaga agacaagagc aaacggttga acacaattct aaatacaatg agcaccatct     2760

acagtactgg aaaagtttgt aacccagata atccacaaga atgcttatta cttgaaccag     2820

gtttgaatga aataatggca aacagtttag actacaatga gaggctctgg gcttgggaaa     2880

gctggagatc tgaggtcggc aagcagctga ggccattata tgaagagtat gtggtcttga     2940

aaaatgagat ggcaagagca aatcattatg aggactatgg ggattattgg agaggagact     3000

atgaagtaaa tggggtagat ggctatgact acagccgcgg ccagttgatt gaagatgtgg     3060

aacatacctt tgaagagatt aaaccattat atgaacatct tcatgcctat gtgagggcaa     3120

agttgatgaa tgcctatcct tcctatatca gtccaattgg atgcctccct gctcatttgc     3180

ttggtgatat gtggggtaga ttttggacaa atctgtactc tttgacagtt ccctttggac     3240

agaaaccaaa catagatgtt actgatgcaa tggtggacca ggcctgggat gcacagagaa     3300

tattcaagga ggccgagaag ttctttgtat ctgttggtct tcctaatatg actcaaggat     3360

tctgggaaaa ttccatgcta acggacccag gaaatgttca gaaagcagtc tgccatccca     3420

cagcttggga cctggggaag ggcgacttca ggatccttat gtgcacaaag gtgacaatgg     3480

acgacttcct gacagctcat catgagatgg ggcatatcca gtatgatatg gcatatgctg     3540

cacaaccttt tctgctaaga aatggagcta atgaaggatt ccatgaagct gttggggaaa     3600

tcatgtcact ttctgcagcc acacctaagc atttaaaatc cattggtctt ctgtcacccg     3660

attttcaaga agacaatgaa acagaaataa acttcctgct caaacaagca ctcacgattg     3720

ttgggactct gccatttact tacatgttag agaagtggag gtggatggtc tttaaagggg     3780

aaattcccaa agaccagtgg atgaaaaagt ggtgggagat gaagcgagag atagttgggg     3840

tggtggaacc tgtgccccat gatgaaacat actgtgaccc cgcatctctg ttccatgttt     3900

ctaatgatta ctcattcatt cgatattaca caaggaccct ttaccaattc cagtttcaag     3960

aagcactttg tcaagcagct aaacatgaag gccctctgca caaatgtgac atctcaaact     4020

ctacagaagc tggacagaaa ctgttcaata tgctgaggct tggaaaatca gaaccctgga     4080

ccctagcatt ggaaaatgtt gtaggagcaa agaacatgaa tgtaaggcca ctgctcaact     4140

actttgagcc cttatttacc tggctgaaag accagaacaa gaattctttt gtgggatgga     4200

gtaccgactg gagtccatat gcagaccaaa gcatcaaagt gaggataagc ctaaaatcag     4260

ctcttggaga taaagcatat gaatggaacg acaatgaaat gtacctgttc cgatcatctg     4320

ttgcatatgc tatgaggcag tactttttaa aagtaaaaaa tcagatgatt ctttttgggg     4380

aggaggatgt gcgagtggct aatttgaaac caagaatctc ctttaatttc tttgtcactg     4440

cacctaaaaa tgtgtctgat atcattccta gaactgaagt tgaaaaggcc atcaggatgt     4500

cccggagccg tatcaatgat gctttccgtc tgaatgacaa cagcctagag tttctgggga     4560

tacagccaac acttggacct cctaaccagc cccctgtttc catatggctg attgtttttg     4620

gagttgtgat gggagtgata gtggttggca ttgtcatcct gatcttcact gggatcagag     4680

atcggaagaa gaaaaataaa gcaagaagtg gagaaaatcc ttatgcctcc atcgatatta     4740

gcaaaggaga aaataatcca ggattccaaa acactgatga tgttcagacc tccttttagc     4800

ccaaatcgga tccgcggccg caaggatctg cgatcgctcc ggtgcccgtc agtgggcaga     4860

gcgcacatcg cccacagtcc ccgagaagtt ggggggaggg gtcggcaatt gaacgggtgc     4920

ctagagaagg tggcgcgggg taaactggga aagtgatgtc gtgtactggc tccgcctttt     4980

tcccgagggt gggggagaac cgtatataag tgcagtagtc gccgtgaacg ttctttttcg     5040

caacgggttt gccgccagaa cacagctgaa gcttcgaggg gctcgcatct ctccttcacg     5100

cgcccgccgc cctacctgag gccgccatcc acgccggttg agtcgcgttc tgccgcctcc     5160

cgcctgtggt gcctcctgaa ctgcgtccgc cgtctaggta agtttaaagc tcaggtcgag     5220

accgggcctt tgtccggcgc tcccttggag cctacctaga ctcagccggc tctccacgct     5280

ttgcctgacc ctgcttgctc aactctacgt ctttgtttcg ttttctgttc tgcgccgtta     5340

cagatccaag ctgtgaccgg cgcctacgat atgaccgagt acaagcccac ggtgcgcctc     5400

gccacccgcg acgacgtccc cagggccgta cgcaccctcg ccgccgcgtt cgccgactac     5460

cccgccacgc gccacaccgt cgatccggac cgccacatcg agcgggtcac cgagctgcaa     5520

gaactcttcc tcacgcgcgt cgggctcgac atcggcaagg tgtgggtcgc ggacgacggc     5580

gccgcggtgg cggtctggac cacgccggag agcgtcgaag cgggggcggt gttcgccgag     5640

atcggcccgc gcatggccga gttgagcggt tcccggctgg ccgcgcagca acagatggaa     5700

ggcctcctgg cgccgcaccg gcccaaggag cccgcgtggt tcctggccac cgtcggcgtc     5760

tcgcccgacc accagggcaa gggtctgggc agcgccgtcg tgctccccgg agtggaggcg     5820

gccgagcgcg ccggggtgcc cgccttcctg gagacctccg cgccccgcaa cctccccttc     5880

tacgagcggc tcggcttcac cgtcaccgcc gacgtcgagg tgcccgaagg accgcgcacc     5940

tggtgcatga cccgcaagcc cggtgcctga caatcaacct ctggattaca aaatttgtga     6000

aagattgact ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt     6060

aatgcctttg tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa     6120

atcctggttg ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt     6180

gtgcactgtg tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct     6240

cctttccggg actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg     6300

ccttgcccgc tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc     6360

ggggaaatca tcgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg     6420

gacgtccttc tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct     6480

gctgccggct ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc     6540

cctttgggcc gcctccccgc ctggtacctt taagaccaat gacttacaag gcagctgtag     6600

atcttagcca ctttttaaaa gaaaaggggg gactggaagg gctaattcac tcccaacgaa     6660

gataagatct gctttttgct tgtactgggt ctctctggtt agaccagatc tgagcctggg     6720

agctctctgg ctaactaggg aacccactgc ttaagcctca ataaagcttg ccttgagtgc     6780

ttcaagtagt gtgtgcccgt ctgttgtgtg actctggtaa ctagagatcc ctcagaccct     6840

tttagtcagt gtggaaaatc tctagcagta gtagttcatg tcatcttatt attcagtatt     6900

tataacttgc aaagaaatga atatcagaga gtgagaggaa cttgtttatt gcagcttata     6960

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     7020

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgg ctctagctat     7080

cccgccccta actccgccca tcccgcccct aactccgccc agttccgccc attctccgcc     7140

ccatggctga ctaatttttt ttatttatgc agaggccgag gccgcctcgg cctctgagct     7200

attccagaag tagtgaggag gcttttttgg aggcctagac ttttgcagag accaaattcg     7260

taatcatgtc atagctgttt cctgtgtgaa attgttatcc gctcacaatt ccacacaaca     7320

tacgagccgg aagcataaag tgtaaagcct ggggtgccta atgagtgagc taactcacat     7380

taattgcgtt gcgctcactg cccgctttcc agtcgggaaa cctgtcgtgc cagctgcatt     7440

aatgaatcgg ccaacgcgcg gggagaggcg gtttgcgtat tgggcgctct tccgcttcct     7500

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa     7560

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa     7620

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc     7680

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga     7740

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc     7800

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt     7860

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct     7920

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg     7980

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta     8040

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct     8100

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa     8160

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt     8220

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta     8280

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat     8340

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa     8400

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct     8460

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta     8520

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct     8580

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg     8640

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa     8700

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctacaggc atcgtggtgt     8760

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta     8820

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca     8880

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta     8940

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct     9000

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaatacgg gataataccg     9060

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac     9120

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact     9180

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa     9240

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt     9300

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat     9360

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg     9420

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc     9480

cctttcgtct cgcgcgtttc ggtgatgacg gtgaaaacct ctgacacatg cagctcccgg     9540

agacggtcac agcttgtctg taagcggatg ccgggagcag acaagcccgt cagggcgcgt     9600

cagcgggtgt tggcgggtgt cggggctggc ttaactatgc ggcatcagag cagattgtac     9660

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     9720

tcaggcgcca ttcgccattc aggctgcgca actgttggga agggcgatcg gtgcgggcct     9780

cttcgctatt acgccagctg gcgaaagggg gatgtgctgc aaggcgatta agttgggtaa     9840

cgccagggtt ttcccagtca cgacgttgta aaacgacggc cagtgccaag ctg            9893


<210> 25
<211> 8668
<212> DNA
<213> Artificial Sequence


<220> 
<223> Vector for TMPRSS2 transduction

<400> 25
acgcgtgtag tcttatgcaa tactcttgta gtcttgcaac atggtaacga tgagttagca       60

acatgcctta caaggagaga aaaagcaccg tgcatgccga ttggtggaag taaggtggta      120

cgatcgtgcc ttattaggaa ggcaacagac gggtctgaca tggattggac gaaccactga      180

attgccgcat tgcagagata ttgtatttaa gtgcctagct cgatacaata aacgggtctc      240

tctggttaga ccagatctga gcctgggagc tctctggcta actagggaac ccactgctta      300

agcctcaata aagcttgcct tgagtgcttc aagtagtgtg tgcccgtctg ttgtgtgact      360

ctggtaacta gagatccctc agaccctttt agtcagtgtg gaaaatctct agcagtggcg      420

cccgaacagg gacctgaaag cgaaagggaa accagagctc tctcgacgca ggactcggct      480

tgctgaagcg cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt      540

gactagcgga ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag      600

aattagatcg cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt      660

aaaacatata gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt      720

agaaacatca gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg      780

atcagaagaa cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag      840

gatagagata aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag      900

taagaccacc gcacagcaag cggccactga tcttcagacc tggaggagga gatatgaggg      960

acaattggag aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag     1020

cacccaccaa ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag     1080

ctttgttcct tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc     1140

tgacggtaca ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga     1200

gggctattga ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc     1260

aggcaagaat cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg     1320

gttgctctgg aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata     1380

aatctctgga acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca     1440

attacacaag cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg     1500

aacaagaatt attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa     1560

attggctgtg gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa     1620

tagtttttgc tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt     1680

ttcagaccca cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag     1740

gtggagagag agacagagac agatccattc gattagtgaa cggatctcga cggtatcggt     1800

taacttttaa aagaaaaggg gggattgggg ggtacagtgc aggggaaaga atagtagaca     1860

taatagcaac agacatacaa actaaagaat tacaaaaaca aattacaaaa ttcaaaattt     1920

tatcgattac tagtattatg cccagtacat gaccttatgg gactttccta cttggcagta     1980

catctacgta ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt acatcaatgg     2040

gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg acgtcaatgg     2100

gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca actccgcccc     2160

attgacgcaa atgggcggta ggcgtgtacg gtgggaggtt tatataagca gagctcgttt     2220

agtgaaccgt cagatcgcct ggagacgcca tccacgctgt tttgacctcc atagaagatt     2280

ctagagctag cgtttaaact taaggccacc atggctttga actcagggtc accaccagct     2340

attggacctt actatgaaaa ccatggatac caaccggaaa acccctatcc cgcacagccc     2400

actgtggtcc ccactgtcta cgaggtgcat ccggctcagt actacccgtc ccccgtgccc     2460

cagtacgccc cgagggtcct gacgcaggct tccaaccccg tcgtctgcac gcagcccaaa     2520

tccccatccg ggacagtgtg cacctcaaag actaagaaag cactgtgcat caccttgacc     2580

ctggggacct tcctcgtggg agctgcgctg gccgctggcc tactctggaa gttcatgggc     2640

agcaagtgct ccaactctgg gatagagtgc gactcctcag gtacctgcat caacccctct     2700

aactggtgtg atggcgtgtc acactgcccc ggcggggagg acgagaatcg gtgtgttcgc     2760

ctctacggac caaacttcat ccttcaggtg tactcatctc agaggaagtc ctggcaccct     2820

gtgtgccaag acgactggaa cgagaactac gggcgggcgg cctgcaggga catgggctat     2880

aagaataatt tttactctag ccaaggaata gtggatgaca gcggatccac cagctttatg     2940

aaactgaaca caagtgccgg caatgtcgat atctataaaa aactgtacca cagtgatgcc     3000

tgttcttcaa aagcagtggt ttctttacgc tgtatagcct gcggggtcaa cttgaactca     3060

agccgccaga gcaggattgt gggcggcgag agcgcgctcc cgggggcctg gccctggcag     3120

gtcagcctgc acgtccagaa cgtccacgtg tgcggaggct ccatcatcac ccccgagtgg     3180

atcgtgacag ccgcccactg cgtggaaaaa cctcttaaca atccatggca ttggacggca     3240

tttgcgggga ttttgagaca atctttcatg ttctatggag ccggatacca agtagaaaaa     3300

gtgatttctc atccaaatta tgactccaag accaagaaca atgacattgc gctgatgaag     3360

ctgcagaagc ctctgacttt caacgaccta gtgaaaccag tgtgtctgcc caacccaggc     3420

atgatgctgc agccagaaca gctctgctgg atttccgggt ggggggccac cgaggagaaa     3480

gggaagacct cagaagtgct gaacgctgcc aaggtgcttc tcattgagac acagagatgc     3540

aacagcagat atgtctatga caacctgatc acaccagcca tgatctgtgc cggcttcctg     3600

caggggaacg tcgattcttg ccagggtgac agtggagggc ctctggtcac ttcgaagaac     3660

aatatctggt ggctgatagg ggatacaagc tggggttctg gctgtgccaa agcttacaga     3720

ccaggagtgt acgggaatgt gatggtattc acggactgga tttatcgaca aatgagggca     3780

gacggctaag cggccgcaag gatctgcgat cgctccggtg cccgtcagtg ggcagagcgc     3840

acatcgccca cagtccccga gaagttgggg ggaggggtcg gcaattgaac gggtgcctag     3900

agaaggtggc gcggggtaaa ctgggaaagt gatgtcgtgt actggctccg cctttttccc     3960

gagggtgggg gagaaccgta tataagtgca gtagtcgccg tgaacgttct ttttcgcaac     4020

gggtttgccg ccagaacaca gctgaagctt cgaggggctc gcatctctcc ttcacgcgcc     4080

cgccgcccta cctgaggccg ccatccacgc cggttgagtc gcgttctgcc gcctcccgcc     4140

tgtggtgcct cctgaactgc gtccgccgtc taggtaagtt taaagctcag gtcgagaccg     4200

ggcctttgtc cggcgctccc ttggagccta cctagactca gccggctctc cacgctttgc     4260

ctgaccctgc ttgctcaact ctacgtcttt gtttcgtttt ctgttctgcg ccgttacaga     4320

tccaagctgt gaccggcgcc tacgatatgg ccaagccttt gtctcaagaa gaatccaccc     4380

tcattgaaag agcaacggct acaatcaaca gcatccccat ctctgaagac tacagcgtcg     4440

ccagcgcagc tctctctagc gacggccgca tcttcactgg tgtcaatgta tatcatttta     4500

ctgggggacc ttgtgcagaa ctcgtggtgc tgggcactgc tgctgctgcg gcagctggca     4560

acctgacttg tatcgtcgcg atcggaaatg agaacagggg catcttgagc ccctgcggac     4620

ggtgccgaca ggtgcttctc gatctgcatc ctgggatcaa agccatagtg aaggacagtg     4680

atggacagcc gacggcagtt gggattcgtg aattgctgcc ctctggttat gtgtgggagg     4740

gctaacaatc aacctctgga ttacaaaatt tgtgaaagat tgactggtat tcttaactat     4800

gttgctcctt ttacgctatg tggatacgct gctttaatgc ctttgtatca tgctattgct     4860

tcccgtatgg ctttcatttt ctcctccttg tataaatcct ggttgctgtc tctttatgag     4920

gagttgtggc ccgttgtcag gcaacgtggc gtggtgtgca ctgtgtttgc tgacgcaacc     4980

cccactggtt ggggcattgc caccacctgt cagctccttt ccgggacttt cgctttcccc     5040

ctccctattg ccacggcgga actcatcgcc gcctgccttg cccgctgctg gacaggggct     5100

cggctgttgg gcactgacaa ttccgtggtg ttgtcgggga aatcatcgtc ctttccttgg     5160

ctgctcgcct gtgttgccac ctggattctg cgcgggacgt ccttctgcta cgtcccttcg     5220

gccctcaatc cagcggacct tccttcccgc ggcctgctgc cggctctgcg gcctcttccg     5280

cgtcttcgcc ttcgccctca gacgagtcgg atctcccttt gggccgcctc cccgcctggt     5340

acctttaaga ccaatgactt acaaggcagc tgtagatctt agccactttt taaaagaaaa     5400

ggggggactg gaagggctaa ttcactccca acgaagataa gatctgcttt ttgcttgtac     5460

tgggtctctc tggttagacc agatctgagc ctgggagctc tctggctaac tagggaaccc     5520

actgcttaag cctcaataaa gcttgccttg agtgcttcaa gtagtgtgtg cccgtctgtt     5580

gtgtgactct ggtaactaga gatccctcag acccttttag tcagtgtgga aaatctctag     5640

cagtagtagt tcatgtcatc ttattattca gtatttataa cttgcaaaga aatgaatatc     5700

agagagtgag aggaacttgt ttattgcagc ttataatggt tacaaataaa gcaatagcat     5760

cacaaatttc acaaataaag catttttttc actgcattct agttgtggtt tgtccaaact     5820

catcaatgta tcttatcatg tctggctcta gctatcccgc ccctaactcc gcccatcccg     5880

cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt     5940

tatgcagagg ccgaggccgc ctcggcctct gagctattcc agaagtagtg aggaggcttt     6000

tttggaggcc tagacttttg cagagaccaa attcgtaatc atgtcatagc tgtttcctgt     6060

gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa     6120

agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc     6180

tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag     6240

aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt     6300

cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga     6360

atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg     6420

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     6480

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     6540

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     6600

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     6660

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     6720

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     6780

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     6840

tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat     6900

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     6960

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     7020

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     7080

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     7140

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     7200

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     7260

catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg     7320

ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat     7380

aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat     7440

ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg     7500

caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc     7560

attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa     7620

agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc     7680

actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt     7740

ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag     7800

ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt     7860

gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag     7920

atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac     7980

cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc     8040

gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca     8100

gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg     8160

ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat     8220

gacattaacc tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga     8280

tgacggtgaa aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc     8340

ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg     8400

ctggcttaac tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga     8460

aataccgcac agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct     8520

gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa     8580

agggggatgt gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg     8640

ttgtaaaacg acggccagtg ccaagctg                                        8668


<210> 26
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACE2 forward primer

<400> 26
cattggagca agtgttggat ctt                                            23


<210> 27
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> ACE2 reverse primer

<400> 27
gagctaatgc atgccattct ca                                             22


<210> 28
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> TMPRSS2 forward primer

<400> 28
cacggactgg atttatcgac aa                                             22


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> TMPRSS2 reverse primer

<400> 29
cgtcaaggac gaagaccatg t                                              21


<210> 30
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH forward primer

<400> 30
gcacaagagg aagagagaga cc                                             22


<210> 31
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> GAPDH reverse primer

<400> 31
aggggagatt cagtgtggtg                                                20


<210> 32
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Furin Forward

<400> 32
ggaacatgac agctgcaact                                                20


<210> 33
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Furin Reverse

<400> 33
tcgtcacgat ctgcttctca                                                20


<210> 34
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cathepsin L Forward

<400> 34
tagaggcaca gtggaccaag                                                20


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cathepsin L Reverse

<400> 35
atggccattg tgaagctgtg                                                20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cathepsin B Forward

<400> 36
tctctgaccg gatctgcatc                                                20


<210> 37
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cathepsin B Reverse

<400> 37
tcacagggag ggatggagta                                                20


<210> 38
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> PC1 Forward

<400> 38
gcgtgcctga gaagaaagag                                                20


<210> 39
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> PC1 Reverse

<400> 39
atcccgttct ctttcagcca                                                20


<210> 40
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Trypsin Forward

<400> 40
aagtgtgaag cctcctaccc                                                20


<210> 41
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Trypsin Reverse

<400> 41
ggtgtagact ccaggcttgt                                                20


<210> 42
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Matriptase Forward

<400> 42
cccaacaacc agcatgtgaa                                                20


<210> 43
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Matriptase Reverse

<400> 43
actggagtcg taggagaggt                                                20


<210> 44
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Matriptase Forward

<400> 44
agaacgtcct gctcatcaca                                                20


<210> 45
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Matriptase Reverse

<400> 45
tgtgcagtca atgttgggtg                                                20


<210> 46
<211> 6623
<212> DNA
<213> Artificial Sequence


<220> 
<223> HEK293 AAT Vector

<400> 46
gacggatcgg gagatctccc gatcccctat ggtgcactct cagtacaatc tgctctgatg       60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg      120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc      180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt      240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata      300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc      360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc      420

attgacgtca atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt      480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt      540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca      600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg      660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc      720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg      780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca      840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gctggctagc      900

gtttaaactt aagcttgcca ccatgccgtc ttctgtctcg tggggcatcc tcctgctggc      960

aggcctgtgc tgcctggtcc ctgtctccct ggctgaggat ccccagggag atgctgccca     1020

gaagacagat acatcccacc atgatcagga tcacccaacc ttcaacaaga tcacccccaa     1080

cctggctgag ttcgccttca gcctataccg ccagctggca caccagtcca acagcaccaa     1140

tatcttcttc tccccagtga gcatcgctac agcctttgca atgctctccc tggggaccaa     1200

ggctgacact cacgatgaaa tcctggaggg cctgaatttc aacctcacgg agattccgga     1260

ggctcagatc catgaaggct tccaggaact cctccgtacc ctcaaccagc cagacagcca     1320

gctccagctg accaccggca atggcctgtt cctcagcgag ggcctgaagc tagtggataa     1380

gtttttggag gatgttaaaa agttgtacca ctcagaagcc ttcactgtca acttcgggga     1440

caccgaagag gccaagaaac agatcaacga ttacgtggag aagggtactc aagggaaaat     1500

tgtggatttg gtcaaggagc ttgacagaga cacagttttt gctctggtga attacatctt     1560

ctttaaaggc aaatgggaga gaccctttga agtcaaggac accgaggaag aggacttcca     1620

cgtggaccag gtgaccaccg tgaaggtgcc tatgatgaag cgtttaggca tgtttaacat     1680

ccagcactgt aagaagctgt ccagctgggt gctgctgatg aaatacctgg gcaatgccac     1740

cgccatcttc ttcctgcctg atgaggggaa actacagcac ctggaaaatg aactcaccca     1800

cgatatcatc accaagttcc tggaaaatga agacagaagg tctgccagct tacatttacc     1860

caaactgtcc attactggaa cctatgatct gaagagcgtc ctgggtcaac tgggcatcac     1920

taaggtcttc agcaatgggg ctgacctctc cggggtcaca gaggaggcac ccctgaagct     1980

ctccaaggcc gtgcataagg ctgtgctgac catcgacgag aaagggactg aagctgctgg     2040

ggccatgttt ttagaggcca tacccatgtc tatccccccc gaggtcaagt tcaacaaacc     2100

ctttgtcttc ttaatgattg aacaaaatac caagtctccc ctcttcatgg gaaaagtggt     2160

gaatcccacc caaaaataac tcgagtctag agggcccgtt taaacccgct gatcagcctc     2220

gactgtgcct tctagttgcc agccatctgt tgtttgcccc tcccccgtgc cttccttgac     2280

cctggaaggt gccactccca ctgtcctttc ctaataaaat gaggaaattg catcgcattg     2340

tctgagtagg tgtcattcta ttctgggggg tggggtgggg caggacagca agggggagga     2400

ttgggaagac aatagcaggc atgctgggga tgcggtgggc tctatggctt ctgaggcgga     2460

aagaaccagc tggggctcta gggggtatcc ccacgcgccc tgtagcggcg cattaagcgc     2520

ggcgggtgtg gtggttacgc gcagcgtgac cgctacactt gccagcgccc tagcgcccgc     2580

tcctttcgct ttcttccctt cctttctcgc cacgttcgcc ggctttcccc gtcaagctct     2640

aaatcggggg ctccctttag ggttccgatt tagtgcttta cggcacctcg accccaaaaa     2700

acttgattag ggtgatggtt cacgtagtgg gccatcgccc tgatagacgg tttttcgccc     2760

tttgacgttg gagtccacgt tctttaatag tggactcttg ttccaaactg gaacaacact     2820

caaccctatc tcggtctatt cttttgattt ataagggatt ttgccgattt cggcctattg     2880

gttaaaaaat gagctgattt aacaaaaatt taacgcgaat taattctgtg gaatgtgtgt     2940

cagttagggt gtggaaagtc cccaggctcc ccagcaggca gaagtatgca aagcatgcat     3000

ctcaattagt cagcaaccag gtgtggaaag tccccaggct ccccagcagg cagaagtatg     3060

caaagcatgc atctcaatta gtcagcaacc atagtcccgc ccctaactcc gcccatcccg     3120

cccctaactc cgcccagttc cgcccattct ccgccccatg gctgactaat tttttttatt     3180

tatgcagagg ccgaggccgc ctctgcctct gagctattcc agaagtagtg aggaggcttt     3240

tttggaggcc taggcttttg caaaaagctc ccgggagctt gtatatccat tttcggatct     3300

gatcaagaga caggatgagg atcgtttcgc atgattgaac aagatggatt gcacgcaggt     3360

tctccggccg cttgggtgga gaggctattc ggctatgact gggcacaaca gacaatcggc     3420

tgctctgatg ccgccgtgtt ccggctgtca gcgcaggggc gcccggttct ttttgtcaag     3480

accgacctgt ccggtgccct gaatgaactg caggacgagg cagcgcggct atcgtggctg     3540

gccacgacgg gcgttccttg cgcagctgtg ctcgacgttg tcactgaagc gggaagggac     3600

tggctgctat tgggcgaagt gccggggcag gatctcctgt catctcacct tgctcctgcc     3660

gagaaagtat ccatcatggc tgatgcaatg cggcggctgc atacgcttga tccggctacc     3720

tgcccattcg accaccaagc gaaacatcgc atcgagcgag cacgtactcg gatggaagcc     3780

ggtcttgtcg atcaggatga tctggacgaa gagcatcagg ggctcgcgcc agccgaactg     3840

ttcgccaggc tcaaggcgcg catgcccgac ggcgaggatc tcgtcgtgac ccatggcgat     3900

gcctgcttgc cgaatatcat ggtggaaaat ggccgctttt ctggattcat cgactgtggc     3960

cggctgggtg tggcggaccg ctatcaggac atagcgttgg ctacccgtga tattgctgaa     4020

gagcttggcg gcgaatgggc tgaccgcttc ctcgtgcttt acggtatcgc cgctcccgat     4080

tcgcagcgca tcgccttcta tcgccttctt gacgagttct tctgagcggg actctggggt     4140

tcgaaatgac cgaccaagcg acgcccaacc tgccatcacg agatttcgat tccaccgccg     4200

ccttctatga aaggttgggc ttcggaatcg ttttccggga cgccggctgg atgatcctcc     4260

agcgcgggga tctcatgctg gagttcttcg cccaccccaa cttgtttatt gcagcttata     4320

atggttacaa ataaagcaat agcatcacaa atttcacaaa taaagcattt ttttcactgc     4380

attctagttg tggtttgtcc aaactcatca atgtatctta tcatgtctgt ataccgtcga     4440

cctctagcta gagcttggcg taatcatggt catagctgtt tcctgtgtga aattgttatc     4500

cgctcacaat tccacacaac atacgagccg gaagcataaa gtgtaaagcc tggggtgcct     4560

aatgagtgag ctaactcaca ttaattgcgt tgcgctcact gcccgctttc cagtcgggaa     4620

acctgtcgtg ccagctgcat taatgaatcg gccaacgcgc ggggagaggc ggtttgcgta     4680

ttgggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     4740

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     4800

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     4860

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     4920

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     4980

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     5040

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     5100

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     5160

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     5220

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     5280

agtggtggcc taactacggc tacactagaa gaacagtatt tggtatctgc gctctgctga     5340

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     5400

gtagcggttt ttttgtttgc aagcagcaga ttacgcgcag aaaaaaagga tctcaagaag     5460

atcctttgat cttttctacg gggtctgacg ctcagtggaa cgaaaactca cgttaaggga     5520

ttttggtcat gagattatca aaaaggatct tcacctagat ccttttaaat taaaaatgaa     5580

gttttaaatc aatctaaagt atatatgagt aaacttggtc tgacagttac caatgcttaa     5640

tcagtgaggc acctatctca gcgatctgtc tatttcgttc atccatagtt gcctgactcc     5700

ccgtcgtgta gataactacg atacgggagg gcttaccatc tggccccagt gctgcaatga     5760

taccgcgaga cccacgctca ccggctccag atttatcagc aataaaccag ccagccggaa     5820

gggccgagcg cagaagtggt cctgcaactt tatccgcctc catccagtct attaattgtt     5880

gccgggaagc tagagtaagt agttcgccag ttaatagttt gcgcaacgtt gttgccattg     5940

ctacaggcat cgtggtgtca cgctcgtcgt ttggtatggc ttcattcagc tccggttccc     6000

aacgatcaag gcgagttaca tgatccccca tgttgtgcaa aaaagcggtt agctccttcg     6060

gtcctccgat cgttgtcaga agtaagttgg ccgcagtgtt atcactcatg gttatggcag     6120

cactgcataa ttctcttact gtcatgccat ccgtaagatg cttttctgtg actggtgagt     6180

actcaaccaa gtcattctga gaatagtgta tgcggcgacc gagttgctct tgcccggcgt     6240

caatacggga taataccgcg ccacatagca gaactttaaa agtgctcatc attggaaaac     6300

gttcttcggg gcgaaaactc tcaaggatct taccgctgtt gagatccagt tcgatgtaac     6360

ccactcgtgc acccaactga tcttcagcat cttttacttt caccagcgtt tctgggtgag     6420

caaaaacagg aaggcaaaat gccgcaaaaa agggaataag ggcgacacgg aaatgttgaa     6480

tactcatact cttccttttt caatattatt gaagcattta tcagggttat tgtctcatga     6540

gcggatacat atttgaatgt atttagaaaa ataaacaaat aggggttccg cgcacatttc     6600

cccgaaaagt gccacctgac gtc                                             6623


<210> 47
<211> 8143
<212> DNA
<213> Artificial Sequence


<220> 
<223> HEK293T AAT Vector

<400> 47
aaaggcggcc gccaccatgg ggaccctcag cgctccgcct tgtacccaga ggattaagtg       60

gaaagggctg ctgctgacag ccagcctgtt aaacttctgg aacttgccca ccaccgctga      120

ggacccacaa ggcgacgcgg cccagaagac cgatacaagc caccacgacc aagatcatcc      180

taccttcaac aagatcactc ccaacctcgc tgagtttgcc ttctccttgt atcgccagct      240

tgcgcaccaa tccaattcaa ccaatatatt cttcagccca gtaagtatcg ctactgcgtt      300

tgcaatgctt agtttgggaa caaaagcgga cactcacgac gaaatccttg agggcttgaa      360

tttcaacttg accgaaattc cggaggccca gattcacgaa gggttccagg agcttttgag      420

gacactgaac cagccagact cacaattgca acttacaacc ggcaacggac tgtttctttc      480

cgagggcctt aaacttgttg ataaatttct tgaagacgtc aagaagctgt accactcaga      540

agcatttaca gtcaacttcg gcgataccga agaggcaaag aagcaaatca acgactatgt      600

ggagaaggga actcagggga aaatagtaga cctggtaaag gaattggacc gcgacacggt      660

attcgcgttg gttaattaca tctttttcaa gggtaagtgg gaacggccat ttgaagtgaa      720

ggacaccgaa gaagaagact tccacgtaga ccaggtaact actgttaaag tcccaatgat      780

gaaacgattg ggtatgttta acattcagca ttgtaagaag ctctcatcct gggttctttt      840

gatgaaatac ttggggaatg caacggccat attctttctt ccggatgagg gaaagttgca      900

acacctggaa aatgaactca cacacgacat cattacgaaa ttcttggaaa atgaagaccg      960

gaggtccgct tctttgcacc tgccaaaact cagtataacg ggtacatatg acctcaagtc     1020

cgtcctcggt caactgggaa taactaaggt cttttctaac ggagcagatt tgagcggcgt     1080

cacagaagaa gcacctttga aacttagtaa ggctgtccat aaagcggtac tcacaattga     1140

cgagaaaggg accgaagctg cgggggctat gtttctggag gcaatcccaa tgagcatacc     1200

accagaagtt aaatttaaca aacctttcgt tttcctcatg atagagcaaa acacaaaaag     1260

tccgctgttt atgggaaagg tagtgaatcc tacccagaaa gggagcgcta gcgaaaacct     1320

gtacttccaa ggcacttccg cttggtccca tcctcagttt gagaaaggcg gaggtagtgg     1380

cggaggatcc ggtggatctg cttggagcca tccacagttc gaaaagggat cccaccatca     1440

tcaccatcac caccaccatc attaatgact gagtagtcta gaagttgtct cctcctgcac     1500

tgactgactg atacaatcga tttctggatc cgcaggccta atcaacctct ggattacaaa     1560

atttgtgaaa gattgactgg tattcttaac tatgttgctc cttttacgct atgtggatac     1620

gctgctttaa tgcctttgta tcatgctatt gcttcccgta tggctttcat tttctcctcc     1680

ttgtataaat cctggttgct gtctctttat gaggagttgt ggcccgttgt caggcaacgt     1740

ggcgtggtgt gcactgtgtt tgctgacgca acccccactg gttggggcat tgccaccacc     1800

tgtcagctcc tttccgggac tttcgctttc cccctcccta ttgccacggc ggaactcatc     1860

gccgcctgcc ttgcccgctg ctggacaggg gctcggctgt tgggcactga caattccgtg     1920

gtgttgtcgg ggaagctgac gtcctttcca tggctgctcg cctgtgttgc cacctggatt     1980

ctgcgcggga cgtccttctg ctacgtccct tcggccctca atccagcgga ccttccttcc     2040

cgcggcctgc tgccggctct gcggcctctt ccgcgtcttc gccttcgccc tcagacgagt     2100

cggatctccc tttgggccgc ctccccgcct gtctagcttg actgactgag atacagcgta     2160

ccttcagctc acagacatga taagatacat tgatgagttt ggacaaacca caactagaat     2220

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     2280

tataagctgc aataaacaag ttaacaacaa caattgcatt cattttatgt ttcaggttca     2340

gggggaggtg tgggaggttt tttaaagcaa gtaaaacctc tacaaatgtg gtattggccc     2400

atctctatcg gtatcgtagc ataacccctt ggggcctcta aacgggtctt gaggggtttt     2460

ttgtgcccct cgggccggat tgctatctac cggcattggc gcagaaaaaa atgcctgatg     2520

cgacgctgcg cgtcttatac tcccacatat gccagattca gcaacggata cggcttcccc     2580

aacttgccca cttccatacg tgtcctcctt accagaaatt tatccttaag gtcgtcagct     2640

atcctgcagg cgatctctcg atttcgatca agacattcct ttaatggtct tttctggaca     2700

ccactagggg tcagaagtag ttcatcaaac tttcttccct ccctaatctc attggttacc     2760

ttgggctatc gaaacttaat taagcgatct gcatctcaat tagtcagcaa ccatagtccc     2820

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca     2880

tcgctgacta atttttttta tttatgcaga ggccgaggcc gcctcggcct ctgagctatt     2940

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaggag gtagccaaca     3000

tgattgaaca agatggattg cacgcaggtt ctcccgccgc ttgggtggag aggctattcg     3060

gctatgactg ggcacaacag acaatcggct gctctgatgc cgccgtgttc cggctgtcag     3120

cgcaggggcg cccggttctt tttgtcaaga ccgacctgtc cggtgccctg aatgaactcc     3180

aggacgaggc agcgcggcta tcgtggctgg ccacgacggg cgttccttgc gcagctgtgc     3240

tcgacgttgt cactgaagcg ggaagggact ggctgctatt gggcgaagtg ccggggcagg     3300

atctcctgtc atctcacctt gctcctgccg agaaagtatc catcatggct gatgcaatgc     3360

ggcggctgca tacgcttgat ccggctacct gcccattcga ccaccaagcg aaacatcgca     3420

tcgagcgagc acgtactcgg atggaagccg gtcttgtcga tcaggatgat ctggacgaag     3480

agcatcaggg gctcgcgcca gccgaactgt tcgccaggct caaggcgcgg atgcccgacg     3540

gcgaggatct cgtcgtgacc cacggcgatg cctgcttgcc gaatatcatg gtggaaaatg     3600

gccgcttttc tggattcatc gactgtggcc ggctgggtgt ggcggaccgc tatcaggaca     3660

tagcgttggc tacccgtgat attgctgaag agcttggcgg cgaatgggct gaccgcttcc     3720

tcgtgcttta cggtatcgcc gctcccgatt cgcagcgcat cgccttctat cgccttcttg     3780

acgagttctt ctagtatgta agccctgtgc cttctagttg ccagccatct gttgtttgcc     3840

cctcccccgt gccttccttg accctggaag gtgccactcc cactgtcctt tcctaataaa     3900

atgaggaaat tgcatcgcat tgtctgagta ggtgtcattc tattctgggg ggtggggtgg     3960

ggcaggacag caagggggag gattgggaag acaatagcag gcatgctggg gatgcggtgg     4020

gctctatggt taattaacca gtcaagtcag ctacttggcg agatcgactt gtctgggttt     4080

cgactacgct cagaattgcg tcagtcaagt tcgatctggt ccttgctatt gcacccgttc     4140

tccgattacg agtttcattt aaatcatgtg agcaaaaggc cagcaaaagg ccaggaaccg     4200

taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg agcatcacaa     4260

aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt     4320

tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct     4380

gtccgccttt ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct     4440

cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc     4500

cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt     4560

atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc     4620

tacagagttc ttgaagtggt ggcctaacta cggctacact agaagaacag tatttggtat     4680

ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa     4740

acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa     4800

aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga     4860

aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct     4920

tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga     4980

cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc     5040

catagttgca tttaaatttc cgaactctcc aaggccctcg tcggaaaatc ttcaaacctt     5100

tcgtccgatc catcttgcag gctacctctc gaacgaacta tcgcaagtct cttggccggc     5160

cttgcgcctt ggctattgct tggcagcgcc tatcgccagg tattactcca atcccgaata     5220

tccgagatcg ggatcacccg agagaagttc aacctacatc ctcaatcccg atctatccga     5280

gatccgagga atatcgaaat cggggcgcgc ctggtgtacc gagaacgatc ctctcagtgc     5340

gagtctcgac gatccatatc gttgcttggc agtcagccag tcggaatcca gcttgggacc     5400

caggaagtcc aatcgtcaga tattgtactc aagcctggtc acggcagcgt accgatctgt     5460

ttaaacctag atattgatag tctgatcggt caacgtataa tcgagtccta gcttttgcaa     5520

acatctatca agagacagga tcagcaggag gctttcgcat gagtattcaa catttccgtg     5580

tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac ccagaaacgc     5640

tggtgaaagt aaaagatgct gaagatcagt tgggtgcgcg agtgggttac atcgaactgg     5700

atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgcttt ccaatgatga     5760

gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc gggcaagagc     5820

aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtattca ccagtcacag     5880

aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc ataaccatga     5940

gtgataacac tgcggccaac ttacttctga caacgattgg aggaccgaag gagctaaccg     6000

cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa ccggagctga     6060

atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacct     6120

tgcgtaaact attaactggc gaactactta ctctagcttc ccggcaacag ttgatagact     6180

ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg gctggctggt     6240

ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt gcagcactgg     6300

ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt caggcaacta     6360

tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag cattggtaac     6420

cgattctagg tgcattggcg cagaaaaaaa tgcctgatgc gacgctgcgc gtcttatact     6480

cccacatatg ccagattcag caacggatac ggcttcccca acttgcccac ttccatacgt     6540

gtcctcctta ccagaaattt atccttaaga tcgtttaaac tcgactctgg ctctatcgaa     6600

tctccgtcgt ttcgagctta cgcgaacagc cgtggcgctc atttgctcgt cgggcatcga     6660

atctcgtcag ctatcgtcag cttacctttt tggcagcgat cgcggctccc gacatcttgg     6720

accattagct ccacaggtat cttcttccct ctagtggtca taacagcagc ttcagctacc     6780

tctcaattca aaaaacccct caagacccgt ttagaggccc caaggggtta tgctatcaat     6840

cgttgcgtta cacacacaaa aaaccaacac acatccatct tcgatggata gcgattttat     6900

tatctaactg ctgatcgagt gtagccagat ctagtaatca attacggggt cattagttca     6960

tagcccatat atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc     7020

gcccaacgac ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat     7080

agggactttc cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt     7140

acatcaagtg tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc     7200

cgcctggcat tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta     7260

cgtattagtc atcgctatta ccatgctgat gcggttttgg cagtacatca atgggcgtgg     7320

atagcggttt gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt     7380

gttttggcac caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac     7440

gcaaatgggc ggtaggcgtg tacggtggga ggtctatata agcagagctg gtttagtgaa     7500

ccgtcagatc gcctggagac gccatccacg ctgttttgac ctccatagaa gacaccggga     7560

ccgatccagc ctcccctcga agcttacatg tggtaccgag ctcggatcct gagaacttca     7620

gggtgagtct atgggaccct tgatgttttc tttccccttc ttttctatgg ttaagttcat     7680

gtcataggaa ggggagaagt aacagggtac acatattgac caaatcaggg taattttgca     7740

tttgtaattt taaaaaatgc tttcttcttt taatatactt ttttgtttat cttatttcta     7800

atactttccc taatctcttt ctttcagggc aataatgata caatgtatca tgcctctttg     7860

caccattcta aagaataaca gtgataattt ctgggttaag gcaatagcaa tatttctgca     7920

tataaatatt tctgcatata aattgtaact gatgtaagag gtttcatatt gctaatagca     7980

gctacaatcc agctaccatt ctgcttttat tttatggttg ggataaggct ggattattct     8040

gagtccaagc taggcccttt tgctaatcat gttcatacct cttatcttcc tcccacagct     8100

cctgggcaac gtgctggtct gtgtgctggc ccatcacttt ggc                       8143


