                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
       Universite Rennes 1
 
<120>  Anticorps et ses utilisations

<130>  BR 120878

<150>  FR2004349
<151>  2020-04-30

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  1

Lys Ser Ser Gln Ser Leu Leu Asn Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  2
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  2

Phe Ala Ser Thr Arg Asp Ser 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  3

Gln Gln His Tyr Ile Leu Pro Pro Thr 
1               5                   


<210>  4
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  4

Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn Tyr Ala Asn 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  5

Gly Thr Asn Asn Arg Ala Pro 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  6

Ala Leu Trp Tyr Ser Asn Leu Trp Val 
1               5                   


<210>  7
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  7

Arg Ala Ser Glu Asn Ile Phe Ile Tyr Leu Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  8

Asn Ala Lys Thr Leu Ala Glu 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  9

Gln His His Tyr Gly Ile Pro Phe Thr 
1               5                   


<210>  10
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  10

Glu Tyr Thr Met His 
1               5   


<210>  11
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  11

Ser Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  12
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  12

Thr Leu Tyr Tyr Ala Met Asp Tyr 
1               5               


<210>  13
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  13

Ser Tyr Gly Val His 
1               5   


<210>  14
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  14

Val Ile Trp Ala Gly Gly Val Thr His Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  15
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  15

Gly Gly Ala Leu Leu Arg Ser His Phe Asp Tyr 
1               5                   10      


<210>  16
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  16

Asp Thr Tyr Ile His 
1               5   


<210>  17
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  17

Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Leu Gln 
1               5                   10                  15      


Gly 
    


<210>  18
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  18

Arg Asp Gly Thr Tyr Val Tyr Tyr Ala Met Asp Tyr 
1               5                   10          


<210>  19
<211>  113
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  19

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Ser Asn Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Arg Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Val Tyr Phe Ala Ser Thr Arg Asp Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Leu Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Asn Arg Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Ile Leu Pro Pro Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys 
    


<210>  20
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  20

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr His Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


Leu Trp Val Phe Gly Gly Arg Thr Lys Leu Thr Val Leu 
            100                 105                 


<210>  21
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Ile Phe Ile Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Phe Ser Leu Lys Ile Asn Ser Leu Leu Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His His Tyr Gly Ile Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Glu 
            100                 105         


<210>  22
<211>  117
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  22

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Gly Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  23
<211>  119
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  23

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Val Thr His Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Asn Ile Ser Lys Asp Asn Ser Gln Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Arg Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ala Leu Leu Arg Ser His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  24
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  24

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Val Ser Gly Phe Asn Ile Thr Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Lys Leu 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gly Thr Tyr Val Tyr Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  25
<211>  152
<212>  PRT
<213>  artificial sequence

<220>
<223>  recombinant IL1RA

<400>  25

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150         


<210>  26
<211>  177
<212>  PRT
<213>  artificial sequence

<220>
<223>  recombinant IL1RA

<400>  26

Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu 
    


<210>  27
<211>  399
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  27
atggaatcac agacccaggt cctcatgttt cttctgctct gggtatctgg tgcctgtgca       60

gacattgtga tgacacagtc tccatcctcc ctggctatgt cagtaggaca gaaggtcact      120

atgagctgca agtccagtca gagcctttta aatagtagta atcaaaagaa ctatttggcc      180

tggtaccagc agaaaccaag acagtctcct aaacttctgg tatactttgc atccactagg      240

gattctgggg tccctgatcg cttcttaggc agtggatctg ggacagattt cactcttacc      300

atcaaccgtg tgcaggctga agacctggca gattacttct gtcagcaaca ttatattctt      360

cctcccacgt tcggtgctgg gaccaagctg gagctgaaa                             399


<210>  28
<211>  408
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  28
atgggatgga gctggatctt tctctttctc ctgtcaggaa ctgcaggtgt cctctctgag       60

gtccagctgc aacagtctgg acctgagctg gtgaagcctg gggcttcagt gaagatatcc      120

tgcaagactt ctggatacac attcactgaa tacaccatgc actgggtgaa gcagagccat      180

ggaaagagcc ttgagtggat tggaagtatt aatcctaaca atggtggtac taactacaac      240

cagaagttca agggcaaggc cacattgact gtagacaagt cctccaacac agcctacatg      300

gagctccgca gcctgacatc tggtgattct gcagtctatt actgtgcaag aactctctac      360

tatgctatgg actactgggg tcaaggaacc tcagtcaccg tctcctca                   408


<210>  29
<211>  384
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  29
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagctcc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tcactgtgct ctatggtaca gcaacctttg ggtgttcggt      360

ggaagaacca aactgactgt ccta                                             384


<210>  30
<211>  414
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  30
atggctgtcc tggtgctgtt cctctgcctg gttgcatttc caagctgtgt cctgtcccag       60

gtgcagctga aggagtcagg acctggcctg gtggcgccct cacagagcct gtccatcact      120

tgcactgtct ctgggttttc attaaccagc tatggtgtac actgggttcg ccagcctcca      180

ggaaagggtc tggagtggct gggagtaata tgggctggtg gagtcacaca ttataattcg      240

gctctcatgt ccagactgaa catcagcaaa gacaactccc agagccaagt tttcttaaaa      300

atgaacagtc tacgaactga tgacacagcc atgtactact gtgccagagg tggggcatta      360

cttcggtctc actttgacta ctggggccaa ggcaccactc tcacagtctc ctca            414


<210>  31
<211>  381
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  31
atgagtgtgc ccactcaggt cctggggttg ctgctgctgt ggcttacagg tgccagatgt       60

gacatccaga tgactcagtc tccagcctcc ctatctgcat ctgtgggaga aactgtcacc      120

atcacatgtc gagcaagtga gaatattttc atttatttag catggtatca gcaaaaacag      180

ggaaaatctc ctcagctcct ggtctataat gcaaagacct tagcagaagg tgtgccatca      240

aggttcagtg gcagtggatc aggcacacag ttttctctga agatcaacag ccttctgcct      300

gaagattttg ggagttatta ctgtcaacat cattatggta ttccattcac gttcggctcg      360

gggacaaagt tggaaataga a                                                381


<210>  32
<211>  417
<212>  DNA
<213>  artificial sequence

<220>
<223>  antibody fragment

<400>  32
atgaaatgca gctgggttat cttcttcctg atggcagtgg ttacaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagagctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagttt ctggtttcaa cattacagac acctatatac actgggtgaa gcagaggcct      180

gaaaagggct tggagtggat tggaaggatt gatcctgcga atggtaatac taaatatgac      240

ccgaagttac agggcaaggc cactataaca gcagacacat cctccaacac agcctacctg      300

cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag agatggtacc      360

tacgtttact atgctatgga ctactggggt caaggaacct cagtcaccgt ctcctca         417


<210>  33
<211>  159
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isoforme

<400>  33

Met Ala Leu Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser Ser Lys 
1               5                   10                  15      


Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
            20                  25                  30          


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
        35                  40                  45              


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
    50                  55                  60                  


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
65                  70                  75                  80  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
                85                  90                  95      


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
            100                 105                 110         


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
        115                 120                 125             


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
    130                 135                 140                 


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
145                 150                 155                 


<210>  34
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isoforme

<400>  34

Met Ala Leu Ala Asp Leu Tyr Glu Glu Gly Gly Gly Gly Gly Gly Glu 
1               5                   10                  15      


Gly Glu Asp Asn Ala Asp Ser Lys Glu Thr Ile Cys Arg Pro Ser Gly 
            20                  25                  30          


Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln 
        35                  40                  45              


Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln 
    50                  55                  60                  


Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu 
65                  70                  75                  80  


Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser 
                85                  90                  95      


Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn 
            100                 105                 110         


Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe 
        115                 120                 125             


Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys 
    130                 135                 140                 


Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser 
145                 150                 155                 160 


Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe 
                165                 170                 175     


Gln Glu Asp Glu 
            180 


<210>  35
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  isoforme

<400>  35

Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu 
1               5                   10                  15      


Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn 
            20                  25                  30          


Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala Leu Phe 
        35                  40                  45              


Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys Ser Gly 
    50                  55                  60                  


Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu Ser 
65                  70                  75                  80  


Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser 
                85                  90                  95      


Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu 
            100                 105                 110         


Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn Met Pro 
        115                 120                 125             


Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp Glu 
    130                 135                 140             


<210>  36
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  36

Phe Arg Ile Trp Asp Val Asn Gln Lys Thr 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  37

Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu 
1               5                   10  


<210>  38
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  38

Asp Ser Gly Pro Thr Thr 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  39

Ala Met Glu Ala Asp Gln 
1               5       


<210>  40
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  40

Asn Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu 
1               5                   10                  15      


Asp 
    


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  41

Phe Tyr Leu Arg Asn Asn Gln Leu 
1               5               


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  42

Leu Gln Gly Pro Val Asn Leu Glu Glu Lys 
1               5                   10  


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  epitope

<400>  43

His Gly Gly Gly Met Cys Leu 
1               5           


<210>  44
<211>  384
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody VL

<400>  44
atggattttc aagtgcagat tttcagcttc ctgctaatga gtgcctcagt cataatgtcc       60

aggggacaaa ttgttctcac ccagtctcca gcactcatgt ctgcatctcc aggggagaag      120

gtcaccatga cctgcagtgc cagctcaagt gtaagttaca tgtactggta ccagcagaag      180

ccaagatcct cccccaaacc ctggatttat ctcacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaatcag cagcatggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccact cacgttcggt      360

gctgggacca agctggagct gaaa                                             384


<210>  45
<211>  418
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody VH

<400>  45
atgatggtgt taagtcttct gtacctgttg acagcccttc cgggtatcct gtcagacgtg       60

cagcttcagg atcaggacct agcctcgtga aaccttctca gactctgtcc ctcacctgtt      120

ctgtcactgg cgactccatc acagtggtta ctggaactgg atccggaaat tcccagggaa      180

taaacttgag tacatggggt acataagcta cgtggtagca cttactacaa tccatctctc      240

aaaagtcgaa tctccatcac tcgagacaca tccaagaacc atactacctg cagttgaatt      300

ctgtgactac tgaggacaca gccacatatt actgtgcaag atgggggcat gttactacgg      360

tagtagctac tggtacttcg atgtctgggg cgcagggacc acggtcaccg tctcctca        418


<210>  46
<211>  381
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody VL

<400>  46
atggtatcca cacctcagtt ccttgtattt ttgcttttct ggattccagc ctccagaagt       60

gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga cagagtcagt      120

ttctcctgca gggccagtca gaccattggc acaaacatac actggtatca ccaaacaaca      180

aatggttctc caaggcttct cattaagtat gcttctgagt ctatctctgg gatcccttcc      240

aggtttagtg gcagtggatc agggacagat tttactctta ccatcatcag tgtggagtct      300

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccgctcac gttcggtgct      360

gggaccaagc tggagctgaa a                                                381


<210>  47
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antibody VH

<400>  47
atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag       60

gtccaactgc agcagcctgg ggctgagctg gtgaggcctg gggcttcagt gaacctgtcc      120

tgcaaggctt ctggctacac cttcaccaac tactggataa actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat cggaaatatt catccttatg atagttatac tcactacaat      240

caaaagttca agggcaaggc cacattgact gtagacaaat cctccagcac ggcctacatg      300

cagctcagca gcccgacatc tgaggactct gcagtctatt tctgtacaag gaggggggta      360

cgacgggacg actactactt tgactactgg ggccaaggca ccactctcac agtctcctca      420


<210>  48
<211>  151
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated protein

<400>  48

Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile Trp 
1               5                   10                  15      


Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val Ala 
            20                  25                  30          


Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp Val 
        35                  40                  45              


Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly Lys 
    50                  55                  60                  


Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln Leu 
65                  70                  75                  80  


Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp Lys 
                85                  90                  95      


Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe Glu 
            100                 105                 110         


Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala Asp 
        115                 120                 125             


Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val Thr 
    130                 135                 140                 


Lys Phe Tyr Phe Gln Glu Asp 
145                 150     


