               SEQUENCE LISTING

<110> ADURO BIOTECH HOLDINGS, EUROPE B.V.
      RIJKSUNIVERSITEIT GRONINGEN
      ACADEMISCH ZIEKENHUIS GRONINGEN
      DE BRUYN et al.

<120> ANTI-CD103 ANTIBODIES

<130> ABE-0010-PCT

<150> US 62/704,258
<151> 2020-04-30

<160> 45

<170> BiSSAP 1.3.6

<210> 1
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A heavy chain CDR1 (amino acid sequence)

<400> 1
Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               

<210> 2
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A heavy chain CDR2 (amino acid sequence)

<400> 2
Ile Thr Tyr Ser Gly Ser Thr 
1               5           

<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A heavy chain CDR3 (amino acid sequence)

<400> 3
Thr Arg His Tyr Tyr Gly Ser Asp Ala Met Asp Tyr 
1               5                   10          

<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A light chain CDR1 (amino acid sequence)

<400> 4
Gln Asp Val Ser Ile Ala 
1               5       

<210> 5
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A light chain CDR2 (amino acid sequence)

<400> 5
Ser Ala Ser 
1           

<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A light chain CDR3 (amino acid sequence)

<400> 6
Gln Gln His Tyr Ser Thr Pro Trp Thr 
1               5                   

<210> 7
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A heavy chain (amino acid sequence)

<400> 7
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Thr 
                85                  90                  95      
Arg His Tyr Tyr Gly Ser Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 8
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.01A light chain (amino acid sequence)

<400> 8
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Ile Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Thr Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 9
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A heavy chain CDR1 (amino acid sequence)

<400> 9
Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               

<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A heavy chain CDR2 (amino acid sequence)

<400> 10
Ile Thr Tyr Ser Gly Ser Thr 
1               5           

<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A heavy chain CDR3 (amino acid sequence)

<400> 11
Ala Arg Gly Tyr Tyr Gly Ser Asp Ala Met Asp Tyr 
1               5                   10          

<210> 12
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A light chain CDR1 (amino acid sequence)

<400> 12
Gln Asp Val Ser Thr Ala 
1               5       

<210> 13
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A light chain CDR2 (amino acid sequence)

<400> 13
Ser Ala Ser 
1           

<210> 14
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A light chain CDR3 (amino acid sequence)

<400> 14
Gln Gln His Tyr Ser Pro Pro Trp Thr 
1               5                   

<210> 15
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A heavy chain (amino acid sequence)

<400> 15
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  
Gln Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Gly Tyr Tyr Gly Ser Asp Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 16
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.02A light chain (amino acid sequence)

<400> 16
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Ser Thr Ala 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  
Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln His Tyr Ser Pro Pro Trp 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A heavy chain CDR1 (amino acid sequence)

<400> 17
Gly Tyr Ser Phe Thr Gly Tyr Asn 
1               5               

<210> 18
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A heavy chain CDR2 (amino acid sequence)

<400> 18
Ile Asp Pro Tyr Tyr Gly Gly Thr 
1               5               

<210> 19
<211> 19
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A heavy chain CDR3 (amino acid sequence)

<400> 19
Ala Arg Ser Phe Tyr Gly Tyr Asp Ala Gly Ser Pro Tyr Asn Tyr Ala 
1               5                   10                  15      
Met Asp Tyr 
            

<210> 20
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A light chain CDR1 (amino acid sequence)

<400> 20
Gln Asp Val Gly Thr Phe 
1               5       

<210> 21
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A light chain CDR2 (amino acid sequence)

<400> 21
Trp Ala Ser 
1           

<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A light chain CDR3 (amino acid sequence)

<400> 22
His Gln Tyr Ser Ser Tyr Pro Tyr Thr 
1               5                   

<210> 23
<211> 126
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A heavy chain (amino acid sequence)

<400> 23
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Glu Lys Pro Gly Ala 
1               5                   10                  15      
Ser Ala Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          
Asn Met Asn Trp Val Lys Gln Ser Asn Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Asp Pro Tyr Tyr Gly Gly Thr Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Gln Leu Lys Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Phe Tyr Gly Tyr Asp Ala Gly Ser Pro Tyr Asn Tyr Ala 
            100                 105                 110         
Met Asp Tyr Trp Gly Gln Gly Thr Pro Val Thr Val Ser Pro 
        115                 120                 125     

<210> 24
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.05A light chain (amino acid sequence)

<400> 24
Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Phe 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Asp Tyr Phe Cys His Gln Tyr Ser Ser Tyr Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Gln Leu Glu Ile Lys 
            100                 105         

<210> 25
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A heavy chain CDR1 (amino acid sequence)

<400> 25
Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               

<210> 26
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A heavy chain CDR2 (amino acid sequence)

<400> 26
Ile Tyr Pro Gly Ser Gly Ser Thr 
1               5               

<210> 27
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A heavy chain CDR3 (amino acid sequence)

<400> 27
Thr Arg Gly Val Tyr Asp Asn Pro Tyr Tyr Phe Asp Tyr 
1               5                   10              

<210> 28
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A light chain CDR1 (amino acid sequence)

<400> 28
Asp His Ile Asn Asn Trp 
1               5       

<210> 29
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A light chain CDR2 (amino acid sequence)

<400> 29
Gly Ala Thr 
1           

<210> 30
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A light chain CDR3 (amino acid sequence)

<400> 30
Gln Gln Tyr Trp Ser Ile Pro Leu Thr 
1               5                   

<210> 31
<211> 120
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A heavy chain (amino acid sequence)

<400> 31
Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      
Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          
Trp Met His Trp Val Lys Gln Arg His Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asp Glu Lys Phe 
    50                  55                  60                  
Lys Ser Lys Gly Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      
Thr Arg Gly Val Tyr Asp Asn Pro Tyr Tyr Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 

<210> 32
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.06A light chain (amino acid sequence)

<400> 32
Asp Ile Gln Met Thr Gln Ser Ser Ser Asn Leu Ser Val Ser Leu Gly 
1               5                   10                  15      
Gly Arg Val Thr Ile Thr Cys Lys Ala Ser Asp His Ile Asn Asn Trp 
            20                  25                  30          
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Asn Ala Pro Arg Val Leu Ile 
        35                  40                  45              
Ser Gly Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  
Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Leu 
                85                  90                  95      
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A heavy chain CDR1 (amino acid sequence)

<400> 33
Gly Asp Ser Ile Thr Ser Gly Tyr 
1               5               

<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A heavy chain CDR2 (amino acid sequence)

<400> 34
Ile Thr Tyr Ser Gly Ser Thr 
1               5           

<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A heavy chain CDR3 (amino acid sequence)

<400> 35
Ala Arg Asn Tyr Tyr Gly Ser Ser Ser Met Asp Tyr 
1               5                   10          

<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A light chain CDR1 (amino acid sequence)

<400> 36
Gln Asn Val Gly Ser Asp 
1               5       

<210> 37
<211> 3
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A light chain CDR2 (amino acid sequence)

<400> 37
Ser Ala Ser 
1           

<210> 38
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A light chain CDR3 (amino acid sequence)

<400> 38
Gln Gln Tyr Asn Ser Tyr Pro Ser Thr 
1               5                   

<210> 39
<211> 118
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A heavy chain (amino acid sequence)

<400> 39
Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              
Gly Tyr Ile Thr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  
Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      
Arg Asn Tyr Tyr Gly Ser Ser Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         
Ser Val Thr Val Ser Ser 
        115             

<210> 40
<211> 107
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic: hCD103.07A light chain (amino acid sequence)

<400> 40
Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Ala 
1               5                   10                  15      
Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Ser Asp 
            20                  25                  30          
Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Leu Ile 
        35                  40                  45              
Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  
Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Ser 
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         

<210> 41
<211> 1179
<212> PRT
<213> Homo sapiens


<220> 
<223> human integrin Alpha-E (amino acid sequence)

<400> 41
Met Trp Leu Phe His Thr Leu Leu Cys Ile Ala Ser Leu Ala Leu Leu 
1               5                   10                  15      
Ala Ala Phe Asn Val Asp Val Ala Arg Pro Trp Leu Thr Pro Lys Gly 
            20                  25                  30          
Gly Ala Pro Phe Val Leu Ser Ser Leu Leu His Gln Asp Pro Ser Thr 
        35                  40                  45              
Asn Gln Thr Trp Leu Leu Val Thr Ser Pro Arg Thr Lys Arg Thr Pro 
    50                  55                  60                  
Gly Pro Leu His Arg Cys Ser Leu Val Gln Asp Glu Ile Leu Cys His 
65                  70                  75                  80  
Pro Val Glu His Val Pro Ile Pro Lys Gly Arg His Arg Gly Val Thr 
                85                  90                  95      
Val Val Arg Ser His His Gly Val Leu Ile Cys Ile Gln Val Leu Val 
            100                 105                 110         
Arg Arg Pro His Ser Leu Ser Ser Glu Leu Thr Gly Thr Cys Ser Leu 
        115                 120                 125             
Leu Gly Pro Asp Leu Arg Pro Gln Ala Gln Ala Asn Phe Phe Asp Leu 
    130                 135                 140                 
Glu Asn Leu Leu Asp Pro Asp Ala Arg Val Asp Thr Gly Asp Cys Tyr 
145                 150                 155                 160 
Ser Asn Lys Glu Gly Gly Gly Glu Asp Asp Val Asn Thr Ala Arg Gln 
                165                 170                 175     
Arg Arg Ala Leu Glu Lys Glu Glu Glu Glu Asp Lys Glu Glu Glu Glu 
            180                 185                 190         
Asp Glu Glu Glu Glu Glu Ala Gly Thr Glu Ile Ala Ile Ile Leu Asp 
        195                 200                 205             
Gly Ser Gly Ser Ile Asp Pro Pro Asp Phe Gln Arg Ala Lys Asp Phe 
    210                 215                 220                 
Ile Ser Asn Met Met Arg Asn Phe Tyr Glu Lys Cys Phe Glu Cys Asn 
225                 230                 235                 240 
Phe Ala Leu Val Gln Tyr Gly Gly Val Ile Gln Thr Glu Phe Asp Leu 
                245                 250                 255     
Arg Asp Ser Gln Asp Val Met Ala Ser Leu Ala Arg Val Gln Asn Ile 
            260                 265                 270         
Thr Gln Val Gly Ser Val Thr Lys Thr Ala Ser Ala Met Gln His Val 
        275                 280                 285             
Leu Asp Ser Ile Phe Thr Ser Ser His Gly Ser Arg Arg Lys Ala Ser 
    290                 295                 300                 
Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu 
305                 310                 315                 320 
Asn Leu Thr Thr Val Ile Asn Ser Pro Lys Met Gln Gly Val Glu Arg 
                325                 330                 335     
Phe Ala Ile Gly Val Gly Glu Glu Phe Lys Ser Ala Arg Thr Ala Arg 
            340                 345                 350         
Glu Leu Asn Leu Ile Ala Ser Asp Pro Asp Glu Thr His Ala Phe Lys 
        355                 360                 365             
Val Thr Asn Tyr Met Ala Leu Asp Gly Leu Leu Ser Lys Leu Arg Tyr 
    370                 375                 380                 
Asn Ile Ile Ser Met Glu Gly Thr Val Gly Asp Ala Leu His Tyr Gln 
385                 390                 395                 400 
Leu Ala Gln Ile Gly Phe Ser Ala Gln Ile Leu Asp Glu Arg Gln Val 
                405                 410                 415     
Leu Leu Gly Ala Val Gly Ala Phe Asp Trp Ser Gly Gly Ala Leu Leu 
            420                 425                 430         
Tyr Asp Thr Arg Ser Arg Arg Gly Arg Phe Leu Asn Gln Thr Ala Ala 
        435                 440                 445             
Ala Ala Ala Asp Ala Glu Ala Ala Gln Tyr Ser Tyr Leu Gly Tyr Ala 
    450                 455                 460                 
Val Ala Val Leu His Lys Thr Cys Ser Leu Ser Tyr Ile Ala Gly Ala 
465                 470                 475                 480 
Pro Arg Tyr Lys His His Gly Ala Val Phe Glu Leu Gln Lys Glu Gly 
                485                 490                 495     
Arg Glu Ala Ser Phe Leu Pro Val Leu Glu Gly Glu Gln Met Gly Ser 
            500                 505                 510         
Tyr Phe Gly Ser Glu Leu Cys Pro Val Asp Ile Asp Met Asp Gly Ser 
        515                 520                 525             
Thr Asp Phe Leu Leu Val Ala Ala Pro Phe Tyr His Val His Gly Glu 
    530                 535                 540                 
Glu Gly Arg Val Tyr Val Tyr Arg Leu Ser Glu Gln Asp Gly Ser Phe 
545                 550                 555                 560 
Ser Leu Ala Arg Ile Leu Ser Gly His Pro Gly Phe Thr Asn Ala Arg 
                565                 570                 575     
Phe Gly Phe Ala Met Ala Ala Met Gly Asp Leu Ser Gln Asp Lys Leu 
            580                 585                 590         
Thr Asp Val Ala Ile Gly Ala Pro Leu Glu Gly Phe Gly Ala Asp Asp 
        595                 600                 605             
Gly Ala Ser Phe Gly Ser Val Tyr Ile Tyr Asn Gly His Trp Asp Gly 
    610                 615                 620                 
Leu Ser Ala Ser Pro Ser Gln Arg Ile Arg Ala Ser Thr Val Ala Pro 
625                 630                 635                 640 
Gly Leu Gln Tyr Phe Gly Met Ser Met Ala Gly Gly Phe Asp Ile Ser 
                645                 650                 655     
Gly Asp Gly Leu Ala Asp Ile Thr Val Gly Thr Leu Gly Gln Ala Val 
            660                 665                 670         
Val Phe Arg Ser Arg Pro Val Val Arg Leu Lys Val Ser Met Ala Phe 
        675                 680                 685             
Thr Pro Ser Ala Leu Pro Ile Gly Phe Asn Gly Val Val Asn Val Arg 
    690                 695                 700                 
Leu Cys Phe Glu Ile Ser Ser Val Thr Thr Ala Ser Glu Ser Gly Leu 
705                 710                 715                 720 
Arg Glu Ala Leu Leu Asn Phe Thr Leu Asp Val Asp Val Gly Lys Gln 
                725                 730                 735     
Arg Arg Arg Leu Gln Cys Ser Asp Val Arg Ser Cys Leu Gly Cys Leu 
            740                 745                 750         
Arg Glu Trp Ser Ser Gly Ser Gln Leu Cys Glu Asp Leu Leu Leu Met 
        755                 760                 765             
Pro Thr Glu Gly Glu Leu Cys Glu Glu Asp Cys Phe Ser Asn Ala Ser 
    770                 775                 780                 
Val Lys Val Ser Tyr Gln Leu Gln Thr Pro Glu Gly Gln Thr Asp His 
785                 790                 795                 800 
Pro Gln Pro Ile Leu Asp Arg Tyr Thr Glu Pro Phe Ala Ile Phe Gln 
                805                 810                 815     
Leu Pro Tyr Glu Lys Ala Cys Lys Asn Lys Leu Phe Cys Val Ala Glu 
            820                 825                 830         
Leu Gln Leu Ala Thr Thr Val Ser Gln Gln Glu Leu Val Val Gly Leu 
        835                 840                 845             
Thr Lys Glu Leu Thr Leu Asn Ile Asn Leu Thr Asn Ser Gly Glu Asp 
    850                 855                 860                 
Ser Tyr Met Thr Ser Met Ala Leu Asn Tyr Pro Arg Asn Leu Gln Leu 
865                 870                 875                 880 
Lys Arg Met Gln Lys Pro Pro Ser Pro Asn Ile Gln Cys Asp Asp Pro 
                885                 890                 895     
Gln Pro Val Ala Ser Val Leu Ile Met Asn Cys Arg Ile Gly His Pro 
            900                 905                 910         
Val Leu Lys Arg Ser Ser Ala His Val Ser Val Val Trp Gln Leu Glu 
        915                 920                 925             
Glu Asn Ala Phe Pro Asn Arg Thr Ala Asp Ile Thr Val Thr Val Thr 
    930                 935                 940                 
Asn Ser Asn Glu Arg Arg Ser Leu Ala Asn Glu Thr His Thr Leu Gln 
945                 950                 955                 960 
Phe Arg His Gly Phe Val Ala Val Leu Ser Lys Pro Ser Ile Met Tyr 
                965                 970                 975     
Val Asn Thr Gly Gln Gly Leu Ser His His Lys Glu Phe Leu Phe His 
            980                 985                 990         
Val His Gly Glu Asn Leu Phe Gly Ala Glu Tyr Gln Leu Gln Ile Cys 
        995                 1000                1005            
Val Pro Thr Lys Leu Arg Gly Leu Gln Val Val Ala Val Lys Lys Leu 
    1010                1015                1020                
Thr Arg Thr Gln Ala Ser Thr Val Cys Thr Trp Ser Gln Glu Arg Ala 
1025                1030                1035                1040
Cys Ala Tyr Ser Ser Val Gln His Val Glu Glu Trp His Ser Val Ser 
                1045                1050                1055    
Cys Val Ile Ala Ser Asp Lys Glu Asn Val Thr Val Ala Ala Glu Ile 
            1060                1065                1070        
Ser Trp Asp His Ser Glu Glu Leu Leu Lys Asp Val Thr Glu Leu Gln 
        1075                1080                1085            
Ile Leu Gly Glu Ile Ser Phe Asn Lys Ser Leu Tyr Glu Gly Leu Asn 
    1090                1095                1100                
Ala Glu Asn His Arg Thr Lys Ile Thr Val Val Phe Leu Lys Asp Glu 
1105                1110                1115                1120
Lys Tyr His Ser Leu Pro Ile Ile Ile Lys Gly Ser Val Gly Gly Leu 
                1125                1130                1135    
Leu Val Leu Ile Val Ile Leu Val Ile Leu Phe Lys Cys Gly Phe Phe 
            1140                1145                1150        
Lys Arg Lys Tyr Gln Gln Leu Asn Leu Glu Ser Ile Arg Lys Ala Gln 
        1155                1160                1165            
Leu Lys Ser Glu Asn Leu Leu Glu Glu Glu Asn 
    1170                1175                

<210> 42
<211> 798
<212> PRT
<213> Homo sapiens


<220>
<223>  human integrin Beta-7 (amino acid sequence)

<400> 42
Met Val Ala Leu Pro Met Val Leu Val Leu Leu Leu Val Leu Ser Arg 
1               5                   10                  15      
Gly Glu Ser Glu Leu Asp Ala Lys Ile Pro Ser Thr Gly Asp Ala Thr 
            20                  25                  30          
Glu Trp Arg Asn Pro His Leu Ser Met Leu Gly Ser Cys Gln Pro Ala 
        35                  40                  45              
Pro Ser Cys Gln Lys Cys Ile Leu Ser His Pro Ser Cys Ala Trp Cys 
    50                  55                  60                  
Lys Gln Leu Asn Phe Thr Ala Ser Gly Glu Ala Glu Ala Arg Arg Cys 
65                  70                  75                  80  
Ala Arg Arg Glu Glu Leu Leu Ala Arg Gly Cys Pro Leu Glu Glu Leu 
                85                  90                  95      
Glu Glu Pro Arg Gly Gln Gln Glu Val Leu Gln Asp Gln Pro Leu Ser 
            100                 105                 110         
Gln Gly Ala Arg Gly Glu Gly Ala Thr Gln Leu Ala Pro Gln Arg Val 
        115                 120                 125             
Arg Val Thr Leu Arg Pro Gly Glu Pro Gln Gln Leu Gln Val Arg Phe 
    130                 135                 140                 
Leu Arg Ala Glu Gly Tyr Pro Val Asp Leu Tyr Tyr Leu Met Asp Leu 
145                 150                 155                 160 
Ser Tyr Ser Met Lys Asp Asp Leu Glu Arg Val Arg Gln Leu Gly His 
                165                 170                 175     
Ala Leu Leu Val Arg Leu Gln Glu Val Thr His Ser Val Arg Ile Gly 
            180                 185                 190         
Phe Gly Ser Phe Val Asp Lys Thr Val Leu Pro Phe Val Ser Thr Val 
        195                 200                 205             
Pro Ser Lys Leu Arg His Pro Cys Pro Thr Arg Leu Glu Arg Cys Gln 
    210                 215                 220                 
Ser Pro Phe Ser Phe His His Val Leu Ser Leu Thr Gly Asp Ala Gln 
225                 230                 235                 240 
Ala Phe Glu Arg Glu Val Gly Arg Gln Ser Val Ser Gly Asn Leu Asp 
                245                 250                 255     
Ser Pro Glu Gly Gly Phe Asp Ala Ile Leu Gln Ala Ala Leu Cys Gln 
            260                 265                 270         
Glu Gln Ile Gly Trp Arg Asn Val Ser Arg Leu Leu Val Phe Thr Ser 
        275                 280                 285             
Asp Asp Thr Phe His Thr Ala Gly Asp Gly Lys Leu Gly Gly Ile Phe 
    290                 295                 300                 
Met Pro Ser Asp Gly His Cys His Leu Asp Ser Asn Gly Leu Tyr Ser 
305                 310                 315                 320 
Arg Ser Thr Glu Phe Asp Tyr Pro Ser Val Gly Gln Val Ala Gln Ala 
                325                 330                 335     
Leu Ser Ala Ala Asn Ile Gln Pro Ile Phe Ala Val Thr Ser Ala Ala 
            340                 345                 350         
Leu Pro Val Tyr Gln Glu Leu Ser Lys Leu Ile Pro Lys Ser Ala Val 
        355                 360                 365             
Gly Glu Leu Ser Glu Asp Ser Ser Asn Val Val Gln Leu Ile Met Asp 
    370                 375                 380                 
Ala Tyr Asn Ser Leu Ser Ser Thr Val Thr Leu Glu His Ser Ser Leu 
385                 390                 395                 400 
Pro Pro Gly Val His Ile Ser Tyr Glu Ser Gln Cys Glu Gly Pro Glu 
                405                 410                 415     
Lys Arg Glu Gly Lys Ala Glu Asp Arg Gly Gln Cys Asn His Val Arg 
            420                 425                 430         
Ile Asn Gln Thr Val Thr Phe Trp Val Ser Leu Gln Ala Thr His Cys 
        435                 440                 445             
Leu Pro Glu Pro His Leu Leu Arg Leu Arg Ala Leu Gly Phe Ser Glu 
    450                 455                 460                 
Glu Leu Ile Val Glu Leu His Thr Leu Cys Asp Cys Asn Cys Ser Asp 
465                 470                 475                 480 
Thr Gln Pro Gln Ala Pro His Cys Ser Asp Gly Gln Gly His Leu Gln 
                485                 490                 495     
Cys Gly Val Cys Ser Cys Ala Pro Gly Arg Leu Gly Arg Leu Cys Glu 
            500                 505                 510         
Cys Ser Val Ala Glu Leu Ser Ser Pro Asp Leu Glu Ser Gly Cys Arg 
        515                 520                 525             
Ala Pro Asn Gly Thr Gly Pro Leu Cys Ser Gly Lys Gly His Cys Gln 
    530                 535                 540                 
Cys Gly Arg Cys Ser Cys Ser Gly Gln Ser Ser Gly His Leu Cys Glu 
545                 550                 555                 560 
Cys Asp Asp Ala Ser Cys Glu Arg His Glu Gly Ile Leu Cys Gly Gly 
                565                 570                 575     
Phe Gly Arg Cys Gln Cys Gly Val Cys His Cys His Ala Asn Arg Thr 
            580                 585                 590         
Gly Arg Ala Cys Glu Cys Ser Gly Asp Met Asp Ser Cys Ile Ser Pro 
        595                 600                 605             
Glu Gly Gly Leu Cys Ser Gly His Gly Arg Cys Lys Cys Asn Arg Cys 
    610                 615                 620                 
Gln Cys Leu Asp Gly Tyr Tyr Gly Ala Leu Cys Asp Gln Cys Pro Gly 
625                 630                 635                 640 
Cys Lys Thr Pro Cys Glu Arg His Arg Asp Cys Ala Glu Cys Gly Ala 
                645                 650                 655     
Phe Arg Thr Gly Pro Leu Ala Thr Asn Cys Ser Thr Ala Cys Ala His 
            660                 665                 670         
Thr Asn Val Thr Leu Ala Leu Ala Pro Ile Leu Asp Asp Gly Trp Cys 
        675                 680                 685             
Lys Glu Arg Thr Leu Asp Asn Gln Leu Phe Phe Phe Leu Val Glu Asp 
    690                 695                 700                 
Asp Ala Arg Gly Thr Val Val Leu Arg Val Arg Pro Gln Glu Lys Gly 
705                 710                 715                 720 
Ala Asp His Thr Gln Ala Ile Val Leu Gly Cys Val Gly Gly Ile Val 
                725                 730                 735     
Ala Val Gly Leu Gly Leu Val Leu Ala Tyr Arg Leu Ser Val Glu Ile 
            740                 745                 750         
Tyr Asp Arg Arg Glu Tyr Ser Arg Phe Glu Lys Glu Gln Gln Gln Leu 
        755                 760                 765             
Asn Trp Lys Gln Asp Ser Asn Pro Leu Tyr Lys Ser Ala Ile Thr Thr 
    770                 775                 780                 
Thr Ile Asn Pro Arg Phe Gln Glu Ala Asp Ser Pro Thr Leu 
785                 790                 795             

<210> 43
<211> 1178
<212> PRT
<213> Macaca mulatta


<220>
<223>  rhesus integrin Alpha-E (amino acid sequence)

<400> 43
Met Trp Leu Val His Thr Leu Leu Cys Met Ala Ser Leu Ala Pro Leu 
1               5                   10                  15      
Ala Ala Phe Asn Val Asp Val Ala Arg Pro Trp Leu Thr Pro Lys Gly 
            20                  25                  30          
Gly Ala Pro Phe Val Leu Ser Ser Leu Leu His Gln Asp Pro Gly Thr 
        35                  40                  45              
Asn His Thr Trp Leu Leu Val Thr Ser Pro Arg Thr Glu Arg Thr Pro 
    50                  55                  60                  
Val Pro Leu His Arg Cys Ser Leu Val Gln Asp Glu Ile Leu Cys His 
65                  70                  75                  80  
Ser Val Glu His Val Pro Ile Pro Lys Gly Arg His Arg Gly Val Thr 
                85                  90                  95      
Val Ala Arg Ser His His Gly Val Leu Ile Cys Ile Gln Val Leu Ala 
            100                 105                 110         
Arg Arg Pro Tyr Ser Leu Ser Ser Glu Phe Thr Gly Thr Cys Gly Leu 
        115                 120                 125             
Leu Gly Pro Asp Leu Arg Pro Gln Ala Gln Ala Asn Phe Phe Asp Leu 
    130                 135                 140                 
Glu Asn Leu Leu Asp Pro Asp Ala Arg Val Asp Thr Gly Asp Cys Tyr 
145                 150                 155                 160 
Ser Asn Lys Glu Gly Ser Arg Gly Glu Asp Val Asn Thr Ala Arg Arg 
                165                 170                 175     
Arg Arg Ala Leu Glu Lys Glu Glu Glu Glu Glu Asp Glu Glu Glu Glu 
            180                 185                 190         
Glu Asp Glu Glu Glu Glu Ala Gly Thr Glu Ile Ala Ile Ile Leu Asp 
        195                 200                 205             
Gly Ser Gly Ser Ile Asp Pro Pro Asp Phe Gln Arg Ala Lys Asp Phe 
    210                 215                 220                 
Ile Ser Asn Met Met Arg Asn Phe Tyr Glu Lys Cys Phe Glu Cys Asn 
225                 230                 235                 240 
Phe Ala Leu Val Gln Tyr Gly Gly Val Ile Gln Thr Glu Phe Asp Leu 
                245                 250                 255     
Arg Asp Ser Gln Asp Val Met Ala Ser Leu Ala Lys Val Gln Asn Ile 
            260                 265                 270         
Thr Gln Val Gly Ser Val Thr Lys Thr Ala Ser Ala Met Gln His Val 
        275                 280                 285             
Leu Asp Asn Ile Phe Thr Ser Ser His Gly Ser Arg Arg Lys Ala Ser 
    290                 295                 300                 
Lys Val Met Val Val Leu Thr Asp Gly Gly Ile Phe Glu Asp Pro Leu 
305                 310                 315                 320 
Asp Leu Thr Thr Val Ile Asn Ser Pro Lys Met His Gly Val Glu Arg 
                325                 330                 335     
Phe Ala Ile Gly Val Gly Glu Glu Phe Lys Ser Ala Arg Thr Glu Arg 
            340                 345                 350         
Glu Leu Asn Leu Ile Ala Ser Asp Pro Asp Glu Thr His Ala Phe Lys 
        355                 360                 365             
Val Thr Asn Tyr Met Ala Leu Asp Gly Leu Leu Ser Lys Leu Arg Tyr 
    370                 375                 380                 
Asn Ile Ile Ser Met Glu Gly Thr Val Gly Asp Ala Leu His Tyr Gln 
385                 390                 395                 400 
Leu Ala Gln Ile Gly Phe Ser Ala Gln Ile Leu Asp Glu Arg Gln Val 
                405                 410                 415     
Leu Leu Gly Ala Val Gly Ala Phe Asp Trp Ser Gly Gly Ala Leu Leu 
            420                 425                 430         
Tyr Asn Thr Arg Ser Arg Arg Gly Arg Phe Leu Asn Gln Thr Ala Ala 
        435                 440                 445             
Ala Val Asp Gly Glu Ala Ala Gln Tyr Ser Tyr Leu Gly Tyr Ala Val 
    450                 455                 460                 
Ala Val Leu His Lys Thr Cys Ser Val Ser Tyr Val Ala Gly Ala Pro 
465                 470                 475                 480 
Arg Tyr Lys His His Gly Ala Val Phe Glu Leu Gln Lys Glu Gly Thr 
                485                 490                 495     
Glu Thr Ser Phe Leu Pro Val Leu Glu Gly Glu Gln Met Gly Ser Tyr 
            500                 505                 510         
Phe Gly Ser Glu Leu Cys Pro Val Asp Ile Asp Met Asp Gly Thr Thr 
        515                 520                 525             
Asp Phe Leu Leu Val Ala Ala Pro Phe Tyr His Val His Gly Glu Glu 
    530                 535                 540                 
Gly Arg Val Tyr Val Tyr Arg Leu Ser Glu Gln Asp Gly Ser Phe Ser 
545                 550                 555                 560 
Leu Ala Arg Ile Leu Ser Gly His Pro Gly Phe Ala Ser Ala Arg Phe 
                565                 570                 575     
Gly Phe Ala Met Ala Ala Val Gly Asp Ile Ser Gln Asp Lys Leu Thr 
            580                 585                 590         
Asp Val Ala Ile Gly Ala Pro Leu Glu Gly Phe Gly Ala Gly Asp Gly 
        595                 600                 605             
Ala Ser Phe Gly Ser Val Tyr Ile Tyr Asn Gly His Trp Asp Gly Leu 
    610                 615                 620                 
Ser Ala Gly Pro Ser Gln Arg Ile Arg Ala Ser Ala Val Ala Pro Gly 
625                 630                 635                 640 
Leu Gln Tyr Phe Gly Met Ser Val Ala Gly Gly Phe Asp Ile Ser Gly 
                645                 650                 655     
Asp Gly Leu Ala Asp Ile Thr Val Gly Thr Leu Gly Arg Ala Val Val 
            660                 665                 670         
Phe Arg Ser Arg Pro Val Val Arg Leu Glu Val Ser Met Ala Phe Thr 
        675                 680                 685             
Pro Ser Ala Leu Pro Ile Gly Phe Asn Gly Val Val Asn Val Arg Leu 
    690                 695                 700                 
Cys Phe Glu Ile Ser Ser Val Ala Thr Val Ser Ala Ser Gly Leu Arg 
705                 710                 715                 720 
Gly Ala Phe Leu Asn Phe Thr Leu Asp Val Asp Val Gly Lys Glu Arg 
                725                 730                 735     
Lys Arg Leu Gln Cys Ser Asp Gly Arg Ser Cys Leu Gly Cys Leu Arg 
            740                 745                 750         
Glu Trp Ser Ser Gly Ser Arg Leu Cys Glu Asp Leu Leu Leu Val Pro 
        755                 760                 765             
Thr Glu Gly Glu Leu His Glu Glu Asp Cys Phe Ser Asn Ala Thr Val 
    770                 775                 780                 
Lys Val Gly Tyr Gln Leu Gln Thr Pro Glu Gly Gln Thr Asp His Pro 
785                 790                 795                 800 
Gln Pro Ile Leu Asp Arg Tyr Ala Glu Thr Phe Ala Ile Phe Gln Leu 
                805                 810                 815     
Pro Tyr Glu Lys Ala Cys Lys Asn Lys Leu Phe Cys Val Ala Glu Leu 
            820                 825                 830         
Gln Leu Ala Thr Thr Val Ser Gln Gln Glu Leu Val Val Gly Leu Thr 
        835                 840                 845             
Lys Glu Leu Thr Leu Asn Ile Ser Leu Thr Asn Ser Gly Glu Asp Ser 
    850                 855                 860                 
Tyr Met Thr Ser Met Ala Leu Asn Tyr Pro Arg Asn Leu Gln Phe Lys 
865                 870                 875                 880 
Arg Met Gln Lys Pro Pro Ser Pro Asn Ile Gln Cys Asp Asp Pro Gln 
                885                 890                 895     
Pro Ala Ala Ser Val Leu Val Met Thr Cys Arg Ile Gly His Pro Val 
            900                 905                 910         
Leu Arg Arg Ser Ser Ala His Val Ser Val Val Trp Gln Leu Glu Glu 
        915                 920                 925             
Asn Ala Phe Pro Asn Arg Thr Ala Asp Ile Thr Val Thr Val Thr Asn 
    930                 935                 940                 
Ser Asn Glu Arg Arg Ser Val Ala Glu Glu Thr His Thr Leu Gln Phe 
945                 950                 955                 960 
Arg His Gly Phe Val Ala Val Leu Ser Lys Pro Ser Ile Met Tyr Val 
                965                 970                 975     
His Thr Gly Gln Val Leu Ser His His Lys Glu Phe Val Phe His Ile 
            980                 985                 990         
His Gly Glu Asn Leu Phe Gly Ala Glu Tyr Gln Leu Arg Ile Cys Val 
        995                 1000                1005            
Pro Thr Lys Leu Arg Gly Leu Gln Ile Val Thr Val Lys Asn Leu Thr 
    1010                1015                1020                
Arg Thr Gln Ala Phe Thr Val Cys Thr Trp Ser Gln Glu Arg Ala Cys 
1025                1030                1035                1040
Gly Phe Ile Pro Val Gln His Val Glu Glu Trp His Ser Val Ser Cys 
                1045                1050                1055    
Val Ile Ala Ser Asp Lys Glu Asn Val Thr Val Ala Ala Glu Ile Ser 
            1060                1065                1070        
Val Asp His Ser Glu Glu Leu Leu Lys Asp Val Thr Glu Leu Gln Ile 
        1075                1080                1085            
Leu Gly Glu Ile Ser Phe Asn Lys Ser Leu Tyr Glu Gly Leu Asn Ala 
    1090                1095                1100                
Glu Asn His Arg Thr Lys Ile Thr Val Val Phe Leu Lys Asp Glu Lys 
1105                1110                1115                1120
Tyr His Ser Leu Pro Val Ile Ile Lys Gly Ser Ile Gly Gly Leu Leu 
                1125                1130                1135    
Val Leu Ile Val Ile Leu Val Ile Leu Phe Lys Cys Gly Phe Phe Lys 
            1140                1145                1150        
Arg Lys Tyr Gln Gln Leu Asn Leu Glu Asn Ile Arg Lys Ala Gln Leu 
        1155                1160                1165            
Lys Ser Glu Thr Leu Leu Glu Glu Glu Asn 
    1170                1175            

<210> 44
<211> 807
<212> PRT
<213> Macaca mulatta


<220>
<223>  rhesus integrin Beta-7 (amino acid sequence)

<400> 44
Met Gly Phe Cys His Val Asp Gln Gly Met Val Ala Leu Pro Val Val 
1               5                   10                  15      
Leu Val Leu Leu Leu Val Leu Ser Arg Gly Glu Ser Glu Leu Asp Ala 
            20                  25                  30          
Lys Thr Pro Ser Thr Gly Glu Ala Thr Glu Trp Gly Asn Pro His Leu 
        35                  40                  45              
Ser Leu Leu Gly Ser Cys Gln Pro Ala Pro Ser Cys Gln Lys Cys Ile 
    50                  55                  60                  
Val Ser His Pro Ser Cys Ala Trp Cys Lys Gln Leu Asn Phe Thr Ala 
65                  70                  75                  80  
Ser Gly Glu Ala Glu Ala Arg Arg Cys Ala Arg Arg Glu Glu Leu Leu 
                85                  90                  95      
Ala Arg Gly Cys Pro Leu Glu Glu Leu Glu Glu Pro Arg Gly Gln Gln 
            100                 105                 110         
Glu Val Leu Gln Asp Gln Pro Leu Ser Gln Gly Ala Arg Gly Glu Gly 
        115                 120                 125             
Ala Thr Gln Leu Ala Pro Gln Arg Val Arg Ile Thr Leu Arg Pro Gly 
    130                 135                 140                 
Glu Pro Gln Gln Leu Gln Val Arg Phe Leu Arg Ala Glu Gly Tyr Pro 
145                 150                 155                 160 
Val Asp Leu Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp 
                165                 170                 175     
Leu Glu Arg Val Arg Gln Leu Gly His Ala Leu Leu Val Arg Leu Gln 
            180                 185                 190         
Glu Val Thr His Ser Val Arg Ile Gly Phe Gly Ser Phe Val Asp Lys 
        195                 200                 205             
Thr Val Leu Pro Phe Val Ser Thr Val Pro Ser Lys Leu Arg His Pro 
    210                 215                 220                 
Cys Pro Thr Arg Leu Glu Arg Cys Gln Ser Pro Phe Ser Phe His His 
225                 230                 235                 240 
Val Leu Ser Leu Thr Gly Asp Ala Gln Ala Phe Glu Arg Glu Val Gly 
                245                 250                 255     
Arg Gln Ser Val Ser Gly Asn Leu Asp Ser Pro Glu Gly Gly Phe Asp 
            260                 265                 270         
Ala Ile Leu Gln Ala Ala Leu Cys Gln Glu Gln Ile Gly Trp Arg Asn 
        275                 280                 285             
Val Ser Arg Leu Leu Val Phe Thr Ser Asp Asp Thr Phe His Thr Ala 
    290                 295                 300                 
Gly Asp Gly Lys Leu Gly Gly Ile Phe Met Pro Ser Asp Gly His Cys 
305                 310                 315                 320 
His Leu Asp Ser Asn Gly Leu Tyr Ser Arg Ser Thr Glu Phe Asp Tyr 
                325                 330                 335     
Pro Ser Val Gly Gln Val Ala Gln Ala Leu Ser Ala Ala Asn Ile Gln 
            340                 345                 350         
Pro Ile Phe Ala Val Thr Ser Ala Ala Leu Pro Val Tyr Gln Glu Leu 
        355                 360                 365             
Ser Lys Leu Ile Pro Lys Ser Ala Val Gly Glu Leu Ser Glu Asp Ser 
    370                 375                 380                 
Ser Asn Val Val Gln Leu Ile Met Asp Ala Tyr Asn Ser Leu Ser Ser 
385                 390                 395                 400 
Thr Val Thr Leu Glu His Ser Ser Leu Pro Pro Gly Val His Ile Ser 
                405                 410                 415     
Tyr Glu Ser Gln Cys Glu Gly Pro Glu Lys Thr Glu Gly Lys Ala Glu 
            420                 425                 430         
Asp Arg Gly Gln Cys Asn His Val Gln Ile Asn Gln Thr Val Thr Phe 
        435                 440                 445             
Trp Val Ser Leu Gln Ala Thr His Cys Leu Pro Glu Pro His Leu Leu 
    450                 455                 460                 
Arg Leu Arg Ala Leu Gly Phe Ser Glu Glu Leu Ile Val Glu Leu His 
465                 470                 475                 480 
Thr Leu Cys Asp Cys Asn Cys Ser Asp Thr Gln Ala Gln Ala Pro His 
                485                 490                 495     
Cys Ser Asp Gly Gln Gly His Leu Gln Cys Gly Val Cys Ser Cys Ala 
            500                 505                 510         
Pro Gly Arg Leu Gly Arg Leu Cys Glu Cys Ser Glu Ala Glu Leu Ser 
        515                 520                 525             
Ser Leu Asp Leu Glu Ser Gly Cys Arg Ala Pro Asn Gly Thr Gly Pro 
    530                 535                 540                 
Leu Cys Ser Gly Lys Gly Gln Cys Gln Cys Gly His Cys Ser Cys Asn 
545                 550                 555                 560 
Gly Gln Ser Ser Gly His Leu Cys Glu Cys Asp Asp Ala Ser Cys Glu 
                565                 570                 575     
Arg His Glu Gly Ile Leu Cys Gly Gly Phe Gly Arg Cys Gln Cys Gly 
            580                 585                 590         
Val Cys His Cys His Ala Asn Arg Thr Gly Arg Ala Cys Glu Cys Ser 
        595                 600                 605             
Gly Asp Met Asp Ser Cys Ile Ser Pro Glu Gly Gly Leu Cys Ser Gly 
    610                 615                 620                 
His Gly Arg Cys Lys Cys Asn Arg Cys Gln Cys Ser Asp Gly Tyr Tyr 
625                 630                 635                 640 
Gly Ala Leu Cys Asp Gln Cys Pro Gly Cys Lys Thr Pro Cys Glu Arg 
                645                 650                 655     
His Arg Asp Cys Ala Glu Cys Gly Ala Phe Gly Thr Gly Leu Leu Ala 
            660                 665                 670         
Thr Asn Cys Ser Thr Ala Cys Ala His Thr Asn Val Thr Leu Val Leu 
        675                 680                 685             
Ala Pro Ile Leu Asp Asp Gly Trp Cys Lys Glu Arg Thr Leu Asp Asn 
    690                 695                 700                 
His Leu Phe Phe Phe Leu Val Glu Asp Asp Ala Arg Gly Arg Val Val 
705                 710                 715                 720 
Leu Arg Val Arg Pro Gln Glu Lys Gly Ala Asp His Thr Gln Ala Ile 
                725                 730                 735     
Val Leu Gly Cys Val Gly Gly Ile Val Ala Val Gly Leu Gly Leu Val 
            740                 745                 750         
Leu Ala Tyr Arg Leu Ser Val Glu Ile Tyr Asp Arg Arg Glu Tyr Ser 
        755                 760                 765             
Arg Phe Glu Lys Glu Gln Gln Gln Leu Asn Trp Lys Gln Asp Ser Asn 
    770                 775                 780                 
Pro Leu Tyr Lys Ser Ala Ile Thr Thr Thr Ile Asn Pro Arg Phe Gln 
785                 790                 795                 800 
Glu Ala Asp Ser Pro Ile Leu 
                805         

<210> 45
<211> 1032
<212> PRT
<213> Homo sapiens


<220>
<223>  human integrin Alpha-4 (amino acid sequence)

<400> 45
Met Ala Trp Glu Ala Arg Arg Glu Pro Gly Pro Arg Arg Ala Ala Val 
1               5                   10                  15      
Arg Glu Thr Val Met Leu Leu Leu Cys Leu Gly Val Pro Thr Gly Arg 
            20                  25                  30          
Pro Tyr Asn Val Asp Thr Glu Ser Ala Leu Leu Tyr Gln Gly Pro His 
        35                  40                  45              
Asn Thr Leu Phe Gly Tyr Ser Val Val Leu His Ser His Gly Ala Asn 
    50                  55                  60                  
Arg Trp Leu Leu Val Gly Ala Pro Thr Ala Asn Trp Leu Ala Asn Ala 
65                  70                  75                  80  
Ser Val Ile Asn Pro Gly Ala Ile Tyr Arg Cys Arg Ile Gly Lys Asn 
                85                  90                  95      
Pro Gly Gln Thr Cys Glu Gln Leu Gln Leu Gly Ser Pro Asn Gly Glu 
            100                 105                 110         
Pro Cys Gly Lys Thr Cys Leu Glu Glu Arg Asp Asn Gln Trp Leu Gly 
        115                 120                 125             
Val Thr Leu Ser Arg Gln Pro Gly Glu Asn Gly Ser Ile Val Thr Cys 
    130                 135                 140                 
Gly His Arg Trp Lys Asn Ile Phe Tyr Ile Lys Asn Glu Asn Lys Leu 
145                 150                 155                 160 
Pro Thr Gly Gly Cys Tyr Gly Val Pro Pro Asp Leu Arg Thr Glu Leu 
                165                 170                 175     
Ser Lys Arg Ile Ala Pro Cys Tyr Gln Asp Tyr Val Lys Lys Phe Gly 
            180                 185                 190         
Glu Asn Phe Ala Ser Cys Gln Ala Gly Ile Ser Ser Phe Tyr Thr Lys 
        195                 200                 205             
Asp Leu Ile Val Met Gly Ala Pro Gly Ser Ser Tyr Trp Thr Gly Ser 
    210                 215                 220                 
Leu Phe Val Tyr Asn Ile Thr Thr Asn Lys Tyr Lys Ala Phe Leu Asp 
225                 230                 235                 240 
Lys Gln Asn Gln Val Lys Phe Gly Ser Tyr Leu Gly Tyr Ser Val Gly 
                245                 250                 255     
Ala Gly His Phe Arg Ser Gln His Thr Thr Glu Val Val Gly Gly Ala 
            260                 265                 270         
Pro Gln His Glu Gln Ile Gly Lys Ala Tyr Ile Phe Ser Ile Asp Glu 
        275                 280                 285             
Lys Glu Leu Asn Ile Leu His Glu Met Lys Gly Lys Lys Leu Gly Ser 
    290                 295                 300                 
Tyr Phe Gly Ala Ser Val Cys Ala Val Asp Leu Asn Ala Asp Gly Phe 
305                 310                 315                 320 
Ser Asp Leu Leu Val Gly Ala Pro Met Gln Ser Thr Ile Arg Glu Glu 
                325                 330                 335     
Gly Arg Val Phe Val Tyr Ile Asn Ser Gly Ser Gly Ala Val Met Asn 
            340                 345                 350         
Ala Met Glu Thr Asn Leu Val Gly Ser Asp Lys Tyr Ala Ala Arg Phe 
        355                 360                 365             
Gly Glu Ser Ile Val Asn Leu Gly Asp Ile Asp Asn Asp Gly Phe Glu 
    370                 375                 380                 
Asp Val Ala Ile Gly Ala Pro Gln Glu Asp Asp Leu Gln Gly Ala Ile 
385                 390                 395                 400 
Tyr Ile Tyr Asn Gly Arg Ala Asp Gly Ile Ser Ser Thr Phe Ser Gln 
                405                 410                 415     
Arg Ile Glu Gly Leu Gln Ile Ser Lys Ser Leu Ser Met Phe Gly Gln 
            420                 425                 430         
Ser Ile Ser Gly Gln Ile Asp Ala Asp Asn Asn Gly Tyr Val Asp Val 
        435                 440                 445             
Ala Val Gly Ala Phe Arg Ser Asp Ser Ala Val Leu Leu Arg Thr Arg 
    450                 455                 460                 
Pro Val Val Ile Val Asp Ala Ser Leu Ser His Pro Glu Ser Val Asn 
465                 470                 475                 480 
Arg Thr Lys Phe Asp Cys Val Glu Asn Gly Trp Pro Ser Val Cys Ile 
                485                 490                 495     
Asp Leu Thr Leu Cys Phe Ser Tyr Lys Gly Lys Glu Val Pro Gly Tyr 
            500                 505                 510         
Ile Val Leu Phe Tyr Asn Met Ser Leu Asp Val Asn Arg Lys Ala Glu 
        515                 520                 525             
Ser Pro Pro Arg Phe Tyr Phe Ser Ser Asn Gly Thr Ser Asp Val Ile 
    530                 535                 540                 
Thr Gly Ser Ile Gln Val Ser Ser Arg Glu Ala Asn Cys Arg Thr His 
545                 550                 555                 560 
Gln Ala Phe Met Arg Lys Asp Val Arg Asp Ile Leu Thr Pro Ile Gln 
                565                 570                 575     
Ile Glu Ala Ala Tyr His Leu Gly Pro His Val Ile Ser Lys Arg Ser 
            580                 585                 590         
Thr Glu Glu Phe Pro Pro Leu Gln Pro Ile Leu Gln Gln Lys Lys Glu 
        595                 600                 605             
Lys Asp Ile Met Lys Lys Thr Ile Asn Phe Ala Arg Phe Cys Ala His 
    610                 615                 620                 
Glu Asn Cys Ser Ala Asp Leu Gln Val Ser Ala Lys Ile Gly Phe Leu 
625                 630                 635                 640 
Lys Pro His Glu Asn Lys Thr Tyr Leu Ala Val Gly Ser Met Lys Thr 
                645                 650                 655     
Leu Met Leu Asn Val Ser Leu Phe Asn Ala Gly Asp Asp Ala Tyr Glu 
            660                 665                 670         
Thr Thr Leu His Val Lys Leu Pro Val Gly Leu Tyr Phe Ile Lys Ile 
        675                 680                 685             
Leu Glu Leu Glu Glu Lys Gln Ile Asn Cys Glu Val Thr Asp Asn Ser 
    690                 695                 700                 
Gly Val Val Gln Leu Asp Cys Ser Ile Gly Tyr Ile Tyr Val Asp His 
705                 710                 715                 720 
Leu Ser Arg Ile Asp Ile Ser Phe Leu Leu Asp Val Ser Ser Leu Ser 
                725                 730                 735     
Arg Ala Glu Glu Asp Leu Ser Ile Thr Val His Ala Thr Cys Glu Asn 
            740                 745                 750         
Glu Glu Glu Met Asp Asn Leu Lys His Ser Arg Val Thr Val Ala Ile 
        755                 760                 765             
Pro Leu Lys Tyr Glu Val Lys Leu Thr Val His Gly Phe Val Asn Pro 
    770                 775                 780                 
Thr Ser Phe Val Tyr Gly Ser Asn Asp Glu Asn Glu Pro Glu Thr Cys 
785                 790                 795                 800 
Met Val Glu Lys Met Asn Leu Thr Phe His Val Ile Asn Thr Gly Asn 
                805                 810                 815     
Ser Met Ala Pro Asn Val Ser Val Glu Ile Met Val Pro Asn Ser Phe 
            820                 825                 830         
Ser Pro Gln Thr Asp Lys Leu Phe Asn Ile Leu Asp Val Gln Thr Thr 
        835                 840                 845             
Thr Gly Glu Cys His Phe Glu Asn Tyr Gln Arg Val Cys Ala Leu Glu 
    850                 855                 860                 
Gln Gln Lys Ser Ala Met Gln Thr Leu Lys Gly Ile Val Arg Phe Leu 
865                 870                 875                 880 
Ser Lys Thr Asp Lys Arg Leu Leu Tyr Cys Ile Lys Ala Asp Pro His 
                885                 890                 895     
Cys Leu Asn Phe Leu Cys Asn Phe Gly Lys Met Glu Ser Gly Lys Glu 
            900                 905                 910         
Ala Ser Val His Ile Gln Leu Glu Gly Arg Pro Ser Ile Leu Glu Met 
        915                 920                 925             
Asp Glu Thr Ser Ala Leu Lys Phe Glu Ile Arg Ala Thr Gly Phe Pro 
    930                 935                 940                 
Glu Pro Asn Pro Arg Val Ile Glu Leu Asn Lys Asp Glu Asn Val Ala 
945                 950                 955                 960 
His Val Leu Leu Glu Gly Leu His His Gln Arg Pro Lys Arg Tyr Phe 
                965                 970                 975     
Thr Ile Val Ile Ile Ser Ser Ser Leu Leu Leu Gly Leu Ile Val Leu 
            980                 985                 990         
Leu Leu Ile Ser Tyr Val Met Trp Lys Ala Gly Phe Phe Lys Arg Gln 
        995                 1000                1005            
Tyr Lys Ser Ile Leu Gln Glu Glu Asn Arg Arg Asp Ser Trp Ser Tyr 
    1010                1015                1020                
Ile Asn Ser Lys Ser Asn Asp Asp 
1025                1030        

