                         б

<110>  Ƽ޹˾
 
<120>  εհתȩøӦ

<130>  P2021TC1592

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  1323
<212>  DNA
<213>  Pseudomonas fluorescens

<400>  1
atgagtaacg tgaaacagca gaccgcccag attgtggatt ggctgagtag taccctgggt       60

aaagatcatc agtatcgtga agatagcctg agcctgaccg ccaatgaaaa ttatccgagc      120

gccctggttc gtctgaccag cggcagcacc gcaggtgcct tttatcattg cagttttccg      180

tttgaagtgc cggcaggcga atggcatttt ccggaaccgg gccacatgaa tgccattgca      240

gatcaggttc gtgatctggg taaaaccctg attggtgcac aggcctttga ttggcgtccg      300

aatggtggta gtaccgccga acaggcactg atgctggcag catgcaaacc gggcgaaggc      360

tttgtgcatt ttgcccatcg tgatggtggc cattttgccc tggaaagcct ggcccagaaa      420

atgggcattg aaatttttca tctgccggtt aatccgacca gcctgctgat tgatgtggcc      480

aaactggatg aaatggttcg ccgcaatccg catattcgca ttgtgattct ggatcagagt      540

tttaaactgc gttggcagcc gctggcagaa attcgtagtg ttctgccgga tagctgtacc      600

ctgacctatg atatgagcca tgatggcggt ctgattatgg gcggtgtttt tgatagcccg      660

ctgagttgtg gtgccgatat tgttcatggc aatacccata aaaccattcc gggtccgcag      720

aaaggttata ttggctttaa aagcgcccag catccgctgc tggttgatac cagtctgtgg      780

gtgtgcccgc atctgcagag taattgccat gccgaacagc tgccgccgat gtgggttgca      840

ttcaaagaaa tggaactgtt tggccgcgat tatgcagccc agattgttag caatgcaaaa      900

accctggcac gtcatctgca tgaactgggt ctggatgtta ccggcgaaag ttttggtttt      960

acccagaccc atcaggttca ttttgccgtt ggtgacctgc agaaagcact ggatctgtgt     1020

gtgaatagcc tgcatgcagg cggcattcgt agcaccaata ttgaaattcc gggcaaaccg     1080

ggtgtgcatg gcattcgtct gggcgttcag gccatgaccc gccgcggtat gaaagaaaaa     1140

gattttgaag tggtggcacg ctttattgca gatctgtatt ttaaaaagac cgaaccggca     1200

aaagttgcac agcagattaa ggaatttctg caggcatttc cgctggcacc gctggcctat     1260

agttttgata attatctgga tgaagagctg ctggccgcag tgtatcaggg tgcacagcgt     1320

taa                                                                   1323


<210>  2
<211>  440
<212>  PRT
<213>  Pseudomonas fluorescens

<400>  2

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  3
<211>  1323
<212>  DNA
<213>  Pseudomonas sp. 34 E 7

<400>  3
atgagtaacg tgaaacagca gaccgcccag attgtggatt ggctgagtag taccctgggt       60

aaagatcatc agtatcgtga agatagcctg agcctgaccg ccaatgaaaa ttatccgagc      120

gccctggttc gtctgaccag cggcagcacc gcaggtgcct tttatcattg cagttttccg      180

tttgaagtgc cggcaggcga atggcatttt ccggaaccgg gccacatgaa tgccattgca      240

gatcaggttc gtgatctggg taaaaccctg attggtgcac aggcctttga ttggcgtccg      300

aatggtggta gtaccgccga acaggcactg atgctggcag catgcaaacc gggcgaaggc      360

tttgtgcatt ttgcccatcg tgatggtggc cattttgccc tggaaagcct ggcccagaaa      420

atgggcattg aaatttttca tctgccggtt aatccgatta gcctgctgat tgatgtggcc      480

aaactggatg aaatggttcg ccgcaatccg catattcgca ttgtgattct ggatcagagt      540

tttaaactgc gttggcagcc gctggcagaa attcgtagtg ttctgccgga tagctgtacc      600

ctgacctatg atatgagcca tgatggcggt ctgattatgg gcggtgtttt tgatagcccg      660

ctgagttgtg gtgccgatat tgttcatggc aatacccata aaaccattcc gggtccgcag      720

aaaggttata ttggctttaa aagcgcccag catccgctgc tggttgatac cagtctgtgg      780

gtgtgcccgc atctgcagag taattgccat gccgaacagc tgccgccgat gtgggttgca      840

ttcaaagaaa tggaactgtt tggccgcgat tatgcagccc agattgttag caatgcaaaa      900

accctggcac gtcatctgca tgaactgggt ctggatgtta ccggcgaaag ttttggtttt      960

acccagaccc atcaggttca ttttgccgtt ggtgacctgc agaaagcact ggatctgtgt     1020

gtgaatagcc tgcatgcagg cggcattcgt agcaccaata ttgaaattcc gggcaaaccg     1080

ggtgtgcatg gcattcgtct gggcgttcag gccatgaccc gccgcggtat gaaagaaaaa     1140

gattttgaag tggtggcacg ctttattgca gatctgtatt ttaaaaagac cgaaccggca     1200

aaagttgcac agcagattaa ggaatttctg caggcatttc cgctggcacc gctggcctat     1260

agttttgata attatctgga tgatgagctg ctggccgcag tgtatcaggg tgcacagcgt     1320

taa                                                                   1323


<210>  4
<211>  440
<212>  PRT
<213>  Pseudomonas sp. 34 E 7

<400>  4

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Ile Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Asp Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  5
<211>  1323
<212>  DNA
<213>  Pseudomonas sp. Irchel s3a18

<400>  5
atgaagcagg atgaaagtaa tgttggtccg gttattgatt ggctggcaca gaccctgggc       60

caggattata aatatcgtca ggataccctg agtctgaccg ccaatgaaaa ttatccgagt      120

gaactggtgc gtctgaccag cggtagcacc gccggcgctt tttatcattg cagttttccg      180

tttccggttc cgctgggtga atggcatttt ccggaaccgg gccagatgaa tgaaattgcc      240

gatgatctgc gtggtctggc caaacgcatg atgggcgccc aggcctttga ttggcgcccg      300

aatggcggta gtccggccga acaggcactg atgctggcag cctgtaaaca gggcgaaggt      360

tttgttcatt ttgcacatcg cgatggcggt cattttgccc tggaacagct ggccaccaaa      420

atgggtattg aaatttttca tctgccggtt gatccgcaga gtctgctgat tgatgtggca      480

aaactggatg atatggttcg tcgcaatccg catattcgta ttgtgattct ggatcagagt      540

tttaaactgc gttggcagcc gctggccgaa attcgcgcca ttctgccgga tagttgcacc      600

ctgacctatg atatgagcca tgatggcggt ctgattctgg gcggtgtgtt tgatagtccg      660

ctggcatgcg gcgccgatat tgcacatggc aatacccata aaaccattcc gggtccgcag      720

aaaggtttta ttgcattcaa aagcgcccag catccgctgc tggtggaaac cagtctgtgg      780

gtgtgtccgc atctgcagag taattgtcat gccgaactgc tgccgagcat gtgggccgcc      840

tttaaagaaa tggaagcatt tggcccggca tacgctcatc agatggtgcg caatgcaaaa      900

gcactggcca atcagctgca tgaactgggt ctgaatgtta gtggcgaaag ttttggtttt      960

accgaaaccc atcaggttca ttttgccgtt ggtgacctgc agcaggccct gagcatgtgc     1020

gtggatagtc tgcatgccgg tggcattcgt agcaccaata ttgaaattcc gggcaaaccg     1080

ggtatgcatg gcattcgtct gggtgttcag gcaatgaccc gccgcggcat gaaagaagat     1140

gattttcgcc gtgtggcagg tctgattgcc gatctgtatt ttaaacgcac cgaaccggcc     1200

cgtgttgcca gcaaagttaa agaactgctg ggtgactttc cgctggcacc gctggcatat     1260

agctttgatc agcagattga tgaaagtcgt cgccgtctgc tggaacgcgg cattcagcgc     1320

taa                                                                   1323


<210>  6
<211>  440
<212>  PRT
<213>  Pseudomonas sp. Irchel s3a18

<400>  6

Met Lys Gln Asp Glu Ser Asn Val Gly Pro Val Ile Asp Trp Leu Ala 
1               5                   10                  15      


Gln Thr Leu Gly Gln Asp Tyr Lys Tyr Arg Gln Asp Thr Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Glu Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Pro Val Pro 
    50                  55                  60                  


Leu Gly Glu Trp His Phe Pro Glu Pro Gly Gln Met Asn Glu Ile Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Gly Leu Ala Lys Arg Met Met Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Pro Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Gln Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Gln Leu Ala Thr Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asp Pro Gln Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Asp Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ala Ile Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Leu Gly Gly Val Phe Asp Ser Pro Leu Ala Cys Gly 
    210                 215                 220                 


Ala Asp Ile Ala His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Phe Ile Ala Phe Lys Ser Ala Gln His Pro Leu Leu Val Glu 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Leu Leu Pro Ser Met Trp Ala Ala Phe Lys Glu Met Glu Ala Phe Gly 
        275                 280                 285             


Pro Ala Tyr Ala His Gln Met Val Arg Asn Ala Lys Ala Leu Ala Asn 
    290                 295                 300                 


Gln Leu His Glu Leu Gly Leu Asn Val Ser Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Glu Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Gln Ala 
                325                 330                 335     


Leu Ser Met Cys Val Asp Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Met His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Asp Asp Phe Arg Arg 
    370                 375                 380                 


Val Ala Gly Leu Ile Ala Asp Leu Tyr Phe Lys Arg Thr Glu Pro Ala 
385                 390                 395                 400 


Arg Val Ala Ser Lys Val Lys Glu Leu Leu Gly Asp Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Gln Gln Ile Asp Glu Ser Arg Arg Arg 
            420                 425                 430         


Leu Leu Glu Arg Gly Ile Gln Arg 
        435                 440 


<210>  7
<211>  1323
<212>  DNA
<213>  Chitiniphilus shinanonensis

<400>  7
atgacccgca ccaccccgca ggcacgccat gtggtggaac gcctgaatag tgtgctgggt       60

caggattatc gttatcgtga agattgtctg agtctgaccg ccaatgaaaa ttatccgagt      120

gcactggttc gtctggccgg tagtgcaacc gcaggcgcct tttatcattg cagttttccg      180

tttgaagtgc cgccgggtga atggtatttt ccggaaagtg gccgtatggg cgaactggca      240

cagcagctga atgaactggg ccgtagtctg ctgggtgccg gcacctttga ttggcgcccg      300

aatggtggta gcccggcaga acaggccctg atgctggcag cctgtaaaca tggtgaaggt      360

atggtgcatt ttgcacatcg tgatggtggt cattttgcac tggaaaatct ggcacagaaa      420

gcaggcattg atatttttca tctgccggtt gatccgcaga ccctgctgat tgatgttgca      480

cgtctggatg aactggttcg tcgcaatccg cagattcgca ttgttattct ggatcagagt      540

tttaaactgc gttggcagcc gctggcagcc attcgcaaag tgctgccgcc gagttgcacc      600

ctgacctatg ataccagtca tgatggcggt ctgattatgg gcggtgtttt tgatagcccg      660

ctgcattgtg gtgccgatgt tattcatggc aatacccata aaaccgtgcc gggtccgcag      720

aaaggttata ttgcattcaa aagcgccgaa catccgctgc tggtggatac cagtctgtgg      780

ctgtgcccgc atctgcagag taattgtcat gcagaactgc tgccgccgat gtgggttgca      840

ttcaaagaaa tggaagcctt tggtcatgat tatgcaccgc aggttgcccg caatgcaaaa      900

gccctggccg gccatctgca tcgcctgggt tttgaagtga gtggcgaagc atttggcttt      960

accgaaaccc atcaggttca ttttgccgtt ggcgatctgc agcaggcact ggatctgtgc     1020

atgaataccc tgcatcgtgg tggtattcgc agcaccaata ttgaaattcc gggtaaaccg     1080

ggcattcagg gtattcgcct gggtgttcag gcaatgaccc gtcgcggtct gcgcgaagat     1140

gattttgaac aggtggcccg ctttattgca gatctgcatt ttcgcaaagc cgatccggcc     1200

ggtgttgcag cacaggttgc agaatttctg cgcgcctttc cgctggcacc gctgcattat     1260

agctttgatc aggaactgga tcatgaactg ctgcagagtc tgattggcga agcactgcgt     1320

taa                                                                   1323


<210>  8
<211>  440
<212>  PRT
<213>  Chitiniphilus shinanonensis

<400>  8

Met Thr Arg Thr Thr Pro Gln Ala Arg His Val Val Glu Arg Leu Asn 
1               5                   10                  15      


Ser Val Leu Gly Gln Asp Tyr Arg Tyr Arg Glu Asp Cys Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Ala Gly Ser 
        35                  40                  45              


Ala Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Pro Gly Glu Trp Tyr Phe Pro Glu Ser Gly Arg Met Gly Glu Leu Ala 
65                  70                  75                  80  


Gln Gln Leu Asn Glu Leu Gly Arg Ser Leu Leu Gly Ala Gly Thr Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Pro Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys His Gly Glu Gly Met Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Asn Leu Ala Gln Lys Ala Gly Ile Asp 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asp Pro Gln Thr Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Arg Leu Asp Glu Leu Val Arg Arg Asn Pro Gln Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Ala Ile Arg 
            180                 185                 190         


Lys Val Leu Pro Pro Ser Cys Thr Leu Thr Tyr Asp Thr Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu His Cys Gly 
    210                 215                 220                 


Ala Asp Val Ile His Gly Asn Thr His Lys Thr Val Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Ala Phe Lys Ser Ala Glu His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Leu Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Leu Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Ala Phe Gly 
        275                 280                 285             


His Asp Tyr Ala Pro Gln Val Ala Arg Asn Ala Lys Ala Leu Ala Gly 
    290                 295                 300                 


His Leu His Arg Leu Gly Phe Glu Val Ser Gly Glu Ala Phe Gly Phe 
305                 310                 315                 320 


Thr Glu Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Gln Ala 
                325                 330                 335     


Leu Asp Leu Cys Met Asn Thr Leu His Arg Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Ile Gln Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Leu Arg Glu Asp Asp Phe Glu Gln 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu His Phe Arg Lys Ala Asp Pro Ala 
385                 390                 395                 400 


Gly Val Ala Ala Gln Val Ala Glu Phe Leu Arg Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu His Tyr Ser Phe Asp Gln Glu Leu Asp His Glu Leu Leu Gln 
            420                 425                 430         


Ser Leu Ile Gly Glu Ala Leu Arg 
        435                 440 


<210>  9
<211>  1011
<212>  DNA
<213>  Escherichia coli

<400>  9
atgaaggctg cagttgttac gaaggatcat catgttgacg ttacgtataa aacactgcgc       60

tcactgaaac atggcgaagc cctgctgaaa atggagtgtt gtggtgtatg tcataccgat      120

cttcatgtta agaatggcga ttttggtgac aaaaccggcg taattctggg ccatgaaggc      180

atcggtgtgg tggcagaagt gggtccaggt gtcacctcat taaaaccagg cgatcgtgcc      240

agcgtggcgt ggttctacga aggatgcggt cattgcgaat actgtaacag tggtaacgaa      300

acgctctgcc gttcagttaa aaatgccgga tacagcgttg atggcgggat ggcggaagag      360

tgcatcgtgg tcgccgatta cgcggtaaaa gtgccagatg gtctggactc ggcggcggcc      420

agcagcatta cctgtgcggg agtcaccacc tacaaagccg ttaagctgtc aaaaattcgt      480

ccagggcagt ggattgctat ctacggtctt ggcggtctgg gtaacctcgc cctgcaatac      540

gcgaagaatg tctttaacgc caaagtgatc gccattgatg tcaatgatga gcagttaaaa      600

ctggcaaccg aaatgggcgc agatttagcg attaactcac acaccgaaga cgccgccaaa      660

attgtgcagg agaaaactgg tggcgctcac gctgcggtgg taacagcggt agctaaagct      720

gcgtttaact cggcagttga tgctgtccgt gcaggcggtc gtgttgtggc tgtcggtcta      780

ccgccggagt ctatgagcct ggatatccca cgtcttgtgc tggatggtat tgaagtggtc      840

ggttcgctgg tcggcacgcg ccaggattta actgaagcct tccagtttgc cgccgaaggt      900

aaagtggtgc cgaaagtcgc cctgcgtccg ttagcggaca tcaacaccat ctttactgag      960

atggaagaag gcaaaatccg tggccgcatg gtgattgatt tccgtcacta a              1011


<210>  10
<211>  336
<212>  PRT
<213>  Escherichia coli

<400>  10

Met Lys Ala Ala Val Val Thr Lys Asp His His Val Asp Val Thr Tyr 
1               5                   10                  15      


Lys Thr Leu Arg Ser Leu Lys His Gly Glu Ala Leu Leu Lys Met Glu 
            20                  25                  30          


Cys Cys Gly Val Cys His Thr Asp Leu His Val Lys Asn Gly Asp Phe 
        35                  40                  45              


Gly Asp Lys Thr Gly Val Ile Leu Gly His Glu Gly Ile Gly Val Val 
    50                  55                  60                  


Ala Glu Val Gly Pro Gly Val Thr Ser Leu Lys Pro Gly Asp Arg Ala 
65                  70                  75                  80  


Ser Val Ala Trp Phe Tyr Glu Gly Cys Gly His Cys Glu Tyr Cys Asn 
                85                  90                  95      


Ser Gly Asn Glu Thr Leu Cys Arg Ser Val Lys Asn Ala Gly Tyr Ser 
            100                 105                 110         


Val Asp Gly Gly Met Ala Glu Glu Cys Ile Val Val Ala Asp Tyr Ala 
        115                 120                 125             


Val Lys Val Pro Asp Gly Leu Asp Ser Ala Ala Ala Ser Ser Ile Thr 
    130                 135                 140                 


Cys Ala Gly Val Thr Thr Tyr Lys Ala Val Lys Leu Ser Lys Ile Arg 
145                 150                 155                 160 


Pro Gly Gln Trp Ile Ala Ile Tyr Gly Leu Gly Gly Leu Gly Asn Leu 
                165                 170                 175     


Ala Leu Gln Tyr Ala Lys Asn Val Phe Asn Ala Lys Val Ile Ala Ile 
            180                 185                 190         


Asp Val Asn Asp Glu Gln Leu Lys Leu Ala Thr Glu Met Gly Ala Asp 
        195                 200                 205             


Leu Ala Ile Asn Ser His Thr Glu Asp Ala Ala Lys Ile Val Gln Glu 
    210                 215                 220                 


Lys Thr Gly Gly Ala His Ala Ala Val Val Thr Ala Val Ala Lys Ala 
225                 230                 235                 240 


Ala Phe Asn Ser Ala Val Asp Ala Val Arg Ala Gly Gly Arg Val Val 
                245                 250                 255     


Ala Val Gly Leu Pro Pro Glu Ser Met Ser Leu Asp Ile Pro Arg Leu 
            260                 265                 270         


Val Leu Asp Gly Ile Glu Val Val Gly Ser Leu Val Gly Thr Arg Gln 
        275                 280                 285             


Asp Leu Thr Glu Ala Phe Gln Phe Ala Ala Glu Gly Lys Val Val Pro 
    290                 295                 300                 


Lys Val Ala Leu Arg Pro Leu Ala Asp Ile Asn Thr Ile Phe Thr Glu 
305                 310                 315                 320 


Met Glu Glu Gly Lys Ile Arg Gly Arg Met Val Ile Asp Phe Arg His 
                325                 330                 335     


<210>  11
<211>  786
<212>  DNA
<213>  Bacillus subtilis

<400>  11
atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc agggctcgga       60

aaggcaatgg ccattcgctt cggcaaggag caggcaaaag tggtcattaa ctattatagt      120

aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg tgaagctgtt      180

gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca aacggcaatt      240

aaagagttcg gcacactcga tgttatgatt aataatgccg gtcttgaaaa tcctgtgcca      300

tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt aacaggtgcc      360

tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa gggaaatgtc      420

atcaacatgt ccagcgtgca cgaagtgatt ccttggccgt tatttgtcca ctatgcggca      480

agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc gccgaagggc      540

attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc tgaaaaattc      600

gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggcta tatcggcgaa      660

ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag ctacgtcaca      720

ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca ggcaggacgc      780

ggttaa                                                                 786


<210>  12
<211>  261
<212>  PRT
<213>  Bacillus subtilis

<400>  12

Met Tyr Pro Asp Leu Lys Gly Lys Val Val Ala Ile Thr Gly Ala Ala 
1               5                   10                  15      


Ser Gly Leu Gly Lys Ala Met Ala Ile Arg Phe Gly Lys Glu Gln Ala 
            20                  25                  30          


Lys Val Val Ile Asn Tyr Tyr Ser Asn Lys Gln Asp Pro Asn Glu Val 
        35                  40                  45              


Lys Glu Glu Val Ile Lys Ala Gly Gly Glu Ala Val Val Val Gln Gly 
    50                  55                  60                  


Asp Val Thr Lys Glu Glu Asp Val Lys Asn Ile Val Gln Thr Ala Ile 
65                  70                  75                  80  


Lys Glu Phe Gly Thr Leu Asp Val Met Ile Asn Asn Ala Gly Leu Glu 
                85                  90                  95      


Asn Pro Val Pro Ser His Glu Met Pro Leu Lys Asp Trp Asp Lys Val 
            100                 105                 110         


Ile Gly Thr Asn Leu Thr Gly Ala Phe Leu Gly Ser Arg Glu Ala Ile 
        115                 120                 125             


Lys Tyr Phe Val Glu Asn Asp Ile Lys Gly Asn Val Ile Asn Met Ser 
    130                 135                 140                 


Ser Val His Glu Val Ile Pro Trp Pro Leu Phe Val His Tyr Ala Ala 
145                 150                 155                 160 


Ser Lys Gly Gly Ile Lys Leu Met Thr Glu Thr Leu Ala Leu Glu Tyr 
                165                 170                 175     


Ala Pro Lys Gly Ile Arg Val Asn Asn Ile Gly Pro Gly Ala Ile Asn 
            180                 185                 190         


Thr Pro Ile Asn Ala Glu Lys Phe Ala Asp Pro Lys Gln Lys Ala Asp 
        195                 200                 205             


Val Glu Ser Met Ile Pro Met Gly Tyr Ile Gly Glu Pro Glu Glu Ile 
    210                 215                 220                 


Ala Ala Val Ala Ala Trp Leu Ala Ser Lys Glu Ala Ser Tyr Val Thr 
225                 230                 235                 240 


Gly Ile Thr Leu Phe Ala Asp Gly Gly Met Thr Gln Tyr Pro Ser Phe 
                245                 250                 255     


Gln Ala Gly Arg Gly 
            260     


<210>  13
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  13

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ala Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  14
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  14

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  15
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  15

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Met Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  16
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  16

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Thr Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  17
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  17

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  18
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  18

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Tyr Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  19
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  19

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  20
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  20

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  21
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  21

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  22
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  22

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Ser Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  23
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  23

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Gln Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  24
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  24

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Ala Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  25
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  25

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val Cys Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  26
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  26

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  27
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  27

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Gln Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  28
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  28

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Asn Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  29
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  29

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  30
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  30

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  31
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  31

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  32
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  32

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Cys 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  33
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  33

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Tyr Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  34
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  34

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  35
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  35

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Ser Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  36
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  36

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Asn Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  37
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mkutant

<400>  37

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  38
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  38

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Leu Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  39
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  39

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Gln Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  40
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  40

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  41
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  41

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Met Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  42
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  42

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  43
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  43

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Asn Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  44
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  44

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  45
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  45

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  46
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  46

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  47
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  47

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Ser Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  48
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  48

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  49
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  49

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  50
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  50

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Gln Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  51
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  51

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Tyr Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Gln Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  52
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  52

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  53
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  53

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Ser Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  54
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  54

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Asn Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  55
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  55

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  56
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  56

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  57
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  57

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  58
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  58

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Arg Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  59
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  59

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Phe Pro Ser Ala Leu Val Arg Leu Thr Ser Ala 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Ser Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  60
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  60

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Thr Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  61
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  61

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Ser Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  62
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  62

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Met Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  63
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  63

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Gly Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  64
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  64

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Arg Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  65
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  65

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Ala Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Glu Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Cys Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Ala Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  66
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  66

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Met Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His His Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Ile Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Asp Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  67
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  67

Met Lys Gln Asp Glu Ser Asn Val Gly Pro Val Ile Asp Trp Leu Ala 
1               5                   10                  15      


Gln Thr Leu Gly Gln Asp Tyr Lys Tyr Arg Gln Asp Thr Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Glu Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Met Ser Phe Pro Phe Pro Val Pro 
    50                  55                  60                  


Leu Gly Glu Trp His His Pro Glu Pro Gly Gln Met Asn Glu Ile Ala 
65                  70                  75                  80  


Asp Asp Leu Arg Gly Leu Ala Lys Arg Met Met Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Pro Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Gln Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Gln Leu Ala Thr Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asp Pro Gln Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Asp Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ala Ile Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Leu Gly Gly Val Phe Asp Ser Pro Leu Ala Cys Gly 
    210                 215                 220                 


Ala Asp Ile Ala His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Phe Ile Ala Phe Lys Ser Ala Gln His Pro Leu Leu Val Glu 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Leu Leu Pro Ser Met Trp Ala Ala Phe Lys Glu Met Glu Ala Phe Gly 
        275                 280                 285             


Pro Ala Tyr Ala His Gln Met Val Arg Asn Ala Lys Ala Leu Ala Asn 
    290                 295                 300                 


Gln Leu His Glu Leu Gly Leu Asn Val Ser Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Glu Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Gln Ala 
                325                 330                 335     


Leu Ser Met Cys Val Asp Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Met His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Asp Asp Phe Arg Arg 
    370                 375                 380                 


Val Ala Gly Leu Ile Ala Asp Leu Tyr Phe Lys Arg Thr Glu Pro Ala 
385                 390                 395                 400 


Arg Val Ala Ser Lys Val Lys Glu Leu Leu Gly Asp Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Gln Gln Ile Asp Glu Ser Arg Arg Arg 
            420                 425                 430         


Leu Leu Glu Arg Gly Ile Gln Arg 
        435                 440 


<210>  68
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  68

Met Thr Arg Thr Thr Pro Gln Ala Arg His Val Val Glu Arg Leu Asn 
1               5                   10                  15      


Ser Val Leu Gly Gln Asp Tyr Arg Tyr Arg Glu Asp Cys Leu Ser Leu 
            20                  25                  30          


Thr Ala Ser Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Ala Gly Ser 
        35                  40                  45              


Ala Thr Ala Gly Ala Phe Tyr His Met Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Pro Gly Glu Trp Tyr His Pro Glu Ser Gly Arg Met Gly Glu Leu Ala 
65                  70                  75                  80  


Gln Gln Leu Asn Glu Leu Gly Arg Ser Leu Leu Gly Ala Gly Thr Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Pro Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys His Gly Glu Gly Met Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Asn Leu Ala Gln Lys Ala Gly Ile Asp 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asp Pro Gln Thr Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Arg Leu Asp Glu Leu Val Arg Arg Asn Pro Gln Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Ala Ile Arg 
            180                 185                 190         


Lys Val Leu Pro Pro Ser Cys Thr Leu Thr Tyr Asp Thr Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu His Cys Gly 
    210                 215                 220                 


Ala Asp Val Ile His Gly Asn Thr His Lys Thr Val Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Ala Phe Lys Ser Ala Glu His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Leu Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Leu Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Ala Phe Gly 
        275                 280                 285             


His Asp Tyr Ala Pro Gln Val Ala Arg Asn Ala Lys Ala Leu Ala Gly 
    290                 295                 300                 


His Leu His Arg Leu Gly Phe Glu Val Ser Gly Glu Ala Phe Gly Phe 
305                 310                 315                 320 


Thr Glu Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Gln Ala 
                325                 330                 335     


Leu Asp Leu Cys Met Asn Thr Leu His Arg Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Ile Gln Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Leu Arg Glu Asp Asp Phe Glu Gln 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu His Phe Arg Lys Ala Asp Pro Ala 
385                 390                 395                 400 


Gly Val Ala Ala Gln Val Ala Glu Phe Leu Arg Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu His Tyr Ser Phe Asp Gln Glu Leu Asp His Glu Leu Leu Gln 
            420                 425                 430         


Ser Leu Ile Gly Glu Ala Leu Arg 
        435                 440 


<210>  69
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  69

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Gly Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  70
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  70

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Trp Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Phe Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  71
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  71

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Asn Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  72
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant

<400>  72

Met Ser Asn Val Lys Gln Gln Thr Ala Gln Ile Val Asp Trp Leu Ser 
1               5                   10                  15      


Ser Thr Leu Gly Lys Asp His Gln Tyr Arg Glu Asp Ser Leu Ser Leu 
            20                  25                  30          


Thr Ala Asn Glu Asn Tyr Pro Ser Ala Leu Val Arg Leu Thr Ser Gly 
        35                  40                  45              


Ser Thr Ala Gly Ala Phe Tyr His Cys Ser Phe Pro Phe Glu Val Pro 
    50                  55                  60                  


Ala Gly Glu Trp His Ser Pro Glu Pro Gly His Met Asn Ala Ile Ala 
65                  70                  75                  80  


Asp Gln Val Arg Asp Leu Gly Lys Thr Leu Ile Gly Ala Gln Ala Phe 
                85                  90                  95      


Asp Trp Arg Pro Asn Gly Gly Ser Thr Ala Glu Gln Ala Leu Met Leu 
            100                 105                 110         


Ala Ala Cys Lys Pro Gly Glu Gly Phe Val His Phe Ala His Arg Asp 
        115                 120                 125             


Gly Gly His Phe Ala Leu Glu Ser Leu Ala Gln Lys Met Gly Ile Glu 
    130                 135                 140                 


Ile Phe His Leu Pro Val Asn Pro Thr Ser Leu Leu Ile Asp Val Ala 
145                 150                 155                 160 


Lys Leu Asp Glu Met Val Arg Arg Asn Pro His Ile Arg Ile Val Ile 
                165                 170                 175     


Leu Asp Gln Ser Phe Lys Leu Arg Trp Gln Pro Leu Ala Glu Ile Arg 
            180                 185                 190         


Ser Val Leu Pro Asp Ser Cys Thr Leu Thr Tyr Asp Met Ser His Asp 
        195                 200                 205             


Gly Gly Leu Ile Met Gly Gly Val Phe Asp Ser Pro Leu Ser Cys Gly 
    210                 215                 220                 


Ala Asp Ile Val His Gly Asn Thr His Lys Thr Ile Pro Gly Pro Gln 
225                 230                 235                 240 


Lys Gly Tyr Ile Gly Phe Lys Ser Ala Gln His Pro Leu Leu Val Asp 
                245                 250                 255     


Thr Ser Leu Trp Val Cys Pro His Leu Gln Ser Asn Cys His Ala Glu 
            260                 265                 270         


Gln Leu Pro Pro Met Trp Val Ala Phe Lys Glu Met Glu Leu Phe Gly 
        275                 280                 285             


Arg Asp Tyr Ala Ala Gln Ile Val Ser Asn Ala Lys Thr Leu Ala Arg 
    290                 295                 300                 


His Leu His Glu Leu Gly Leu Asp Val Thr Gly Glu Ser Phe Gly Phe 
305                 310                 315                 320 


Thr Gln Thr His Gln Val His Phe Ala Val Gly Asp Leu Gln Lys Ala 
                325                 330                 335     


Leu Asp Leu Cys Val Asn Ser Leu His Ala Gly Gly Ile Arg Ser Thr 
            340                 345                 350         


Asn Ile Glu Ile Pro Gly Lys Pro Gly Val His Gly Ile Arg Leu Gly 
        355                 360                 365             


Val Gln Ala Met Thr Arg Arg Gly Met Lys Glu Lys Asp Phe Glu Val 
    370                 375                 380                 


Val Ala Arg Phe Ile Ala Asp Leu Tyr Phe Lys Lys Thr Glu Pro Ala 
385                 390                 395                 400 


Lys Val Ala Gln Gln Ile Lys Glu Phe Leu Gln Ala Phe Pro Leu Ala 
                405                 410                 415     


Pro Leu Ala Tyr Ser Phe Asp Asn Tyr Leu Asp Glu Glu Leu Leu Ala 
            420                 425                 430         


Ala Val Tyr Gln Gly Ala Gln Arg 
        435                 440 


<210>  73
<211>  364
<212>  PRT
<213>  Candida boidinii

<400>  73

Met Lys Ile Val Leu Val Leu Tyr Asp Ala Gly Lys His Ala Ala Asp 
1               5                   10                  15      


Glu Glu Lys Leu Tyr Gly Cys Thr Glu Asn Lys Leu Gly Ile Ala Asn 
            20                  25                  30          


Trp Leu Lys Asp Gln Gly His Glu Leu Ile Thr Thr Ser Asp Lys Glu 
        35                  40                  45              


Gly Glu Thr Ser Glu Leu Asp Lys His Ile Pro Asp Ala Asp Ile Ile 
    50                  55                  60                  


Ile Thr Thr Pro Phe His Pro Ala Tyr Ile Thr Lys Glu Arg Leu Asp 
65                  70                  75                  80  


Lys Ala Lys Asn Leu Lys Leu Val Val Val Ala Gly Val Gly Ser Asp 
                85                  90                  95      


His Ile Asp Leu Asp Tyr Ile Asn Gln Thr Gly Lys Lys Ile Ser Val 
            100                 105                 110         


Leu Glu Val Thr Gly Ser Asn Val Val Ser Val Ala Glu His Val Val 
        115                 120                 125             


Met Thr Met Leu Val Leu Val Arg Asn Phe Val Pro Ala His Glu Gln 
    130                 135                 140                 


Ile Ile Asn His Asp Trp Glu Val Ala Ala Ile Ala Lys Asp Ala Tyr 
145                 150                 155                 160 


Asp Ile Glu Gly Lys Thr Ile Ala Thr Ile Gly Ala Gly Arg Ile Gly 
                165                 170                 175     


Tyr Arg Val Leu Glu Arg Leu Leu Pro Phe Asn Pro Lys Glu Leu Leu 
            180                 185                 190         


Tyr Tyr Asp Tyr Gln Ala Leu Pro Lys Glu Ala Glu Glu Lys Val Gly 
        195                 200                 205             


Ala Arg Arg Val Glu Asn Ile Glu Glu Leu Val Ala Gln Ala Asp Ile 
    210                 215                 220                 


Val Thr Val Asn Ala Pro Leu His Ala Gly Thr Lys Gly Leu Ile Asn 
225                 230                 235                 240 


Lys Glu Leu Leu Ser Lys Phe Lys Lys Gly Ala Trp Leu Val Asn Thr 
                245                 250                 255     


Ala Arg Gly Ala Ile Cys Val Ala Glu Asp Val Ala Ala Ala Leu Glu 
            260                 265                 270         


Ser Gly Gln Leu Arg Gly Tyr Gly Gly Asp Val Trp Phe Pro Gln Pro 
        275                 280                 285             


Ala Pro Lys Asp His Pro Trp Arg Asp Met Arg Asn Lys Tyr Gly Ala 
    290                 295                 300                 


Gly Asn Ala Met Thr Pro His Tyr Ser Gly Thr Thr Leu Asp Ala Gln 
305                 310                 315                 320 


Thr Arg Tyr Ala Glu Gly Thr Lys Asn Ile Leu Glu Ser Phe Phe Thr 
                325                 330                 335     


Gly Lys Phe Asp Tyr Arg Pro Gln Asp Ile Ile Leu Leu Asn Gly Glu 
            340                 345                 350         


Tyr Val Thr Lys Ala Tyr Gly Lys His Asp Lys Lys 
        355                 360                 


