                         SEQUENCE LISTING

<110>  Ŵѧ
 
<120>  ɸѡ״ȾϼļԼⷽ

<130>  IEC200146PCT

<150>  CN202010365755.7
<151>  2020-04-30

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  235
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV-2-RBD

<400>  1

Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
1               5                   10                  15      


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            20                  25                  30          


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        35                  40                  45              


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    50                  55                  60                  


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
65                  70                  75                  80  


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                85                  90                  95      


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            100                 105                 110         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        115                 120                 125             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    130                 135                 140                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
145                 150                 155                 160 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                165                 170                 175     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            180                 185                 190         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        195                 200                 205             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    210                 215                 220                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
225                 230                 235 


<210>  2
<211>  705
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV-2-RBD

<400>  2
agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg       60

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc      120

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc      180

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg      240

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc      300

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc      360

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg      420

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc      480

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac      540

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc      600

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag      660

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggc                      705


<210>  3
<211>  60
<212>  DNA
<213>  ˹

<220>
<223>  B2Mźģ

<400>  3
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60


<210>  4
<211>  714
<212>  DNA
<213>  ˹

<220>
<223>  ɫӫ⵰mGamillus

<400>  4
gtgagcaagg gcgaggaggc atctggcaga gccctgttcc agtaccccat gaccagcaag       60

atcgagctga acggcgagat caacggcaag aaattcaagg tggccggcga gggcttcacc      120

cccagcagcg gcagattcaa catgcacgcc tactgcacca ccggcgacct gcctatgagc      180

tgggtcgtga ttgccagccc cctccagtac ggcttccaca tgttcgccca ctaccccgag      240

gacatcacac actttttcca ggaatgcttc cccggcagct acaccctgga ccggaccctg      300

agaatggaag gcgacggcac cctgaccacc caccacgagt acagcctgga ggacggctgc      360

gtgacctcca agaccaccct gaatgccagc ggcttcgacc ctaagggcgc caccatgacc      420

aagagcttcg tgaaacaact gcctaacgag gtgaagatca ccccccacgg ccccaacggc      480

atcagactga ccagcaccgt gctgtacctg aaggaggatg gcaccatcca gatcggcacc      540

caggactgca tcgtgacccc tgtgggcgga aggaaagtga cccagcccaa ggcccacttc      600

ctgcacaccc agatcatcca gaagaaggac cccaacgaca cccgggacca catcgtgcag      660

acagaactgg ccgtggccgg caatctgtgg cacggcatgg acgagctgta caag            714


<210>  5
<211>  705
<212>  DNA
<213>  ˹

<220>
<223>  ɫӫ⵰mNeonGreen

<400>  5
gtgagcaagg gcgaggagga caacatggcc agcctgcccg ccacccacga gctgcacatc       60

ttcggcagca tcaacggcgt ggacttcgac atggtgggcc agggcaccgg caaccccaac      120

gacggctacg aggagctgaa cctgaagagc accaagggcg acctgcagtt cagcccctgg      180

atcttagtgc cccacatcgg ctacggcttc caccagtacc tgccctaccc cgacggcatg      240

agccccttcc aggccgccat ggtggacggc agcggctacc aggtgcaccg caccatgcag      300

ttcgaggacg gcgccagcct gaccgtgaac taccgctaca cctacgaggg cagccacatc      360

aagggcgagg cccaggtgaa gggcaccggc ttccccgccg acggccccgt gatgaccaac      420

agcctgaccg ccgccgactg gtgccgcagc aagaagacct accccaacga caagaccatc      480

atcagcacct tcaagtggag ctacaccacc ggcaacggca agcgctaccg cagcaccgcc      540

cgcaccacct acaccttcgc caagcccatg gccgccaact acctgaagaa ccagcccatg      600

tacgtgttcc gcaagaccga gctgaagcac agcaagaccg agctgaactt caaggagtgg      660

cagaaggcct tcaccgacgt gatgggcatg gacgagctgt acaag                      705


<210>  6
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  ԰У

<400>  6

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  7
<211>  525
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-RBG

<400>  7

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    130                 135                 140                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            180                 185                 190         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        195                 200                 205             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Arg 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Val Ser Lys Gly Glu Glu Ala Ser Gly Arg 
        275                 280                 285             


Ala Leu Phe Gln Tyr Pro Met Thr Ser Lys Ile Glu Leu Asn Gly Glu 
    290                 295                 300                 


Ile Asn Gly Lys Lys Phe Lys Val Ala Gly Glu Gly Phe Thr Pro Ser 
305                 310                 315                 320 


Ser Gly Arg Phe Asn Met His Ala Tyr Cys Thr Thr Gly Asp Leu Pro 
                325                 330                 335     


Met Ser Trp Val Val Ile Ala Ser Pro Leu Gln Tyr Gly Phe His Met 
            340                 345                 350         


Phe Ala His Tyr Pro Glu Asp Ile Thr His Phe Phe Gln Glu Cys Phe 
        355                 360                 365             


Pro Gly Ser Tyr Thr Leu Asp Arg Thr Leu Arg Met Glu Gly Asp Gly 
    370                 375                 380                 


Thr Leu Thr Thr His His Glu Tyr Ser Leu Glu Asp Gly Cys Val Thr 
385                 390                 395                 400 


Ser Lys Thr Thr Leu Asn Ala Ser Gly Phe Asp Pro Lys Gly Ala Thr 
                405                 410                 415     


Met Thr Lys Ser Phe Val Lys Gln Leu Pro Asn Glu Val Lys Ile Thr 
            420                 425                 430         


Pro His Gly Pro Asn Gly Ile Arg Leu Thr Ser Thr Val Leu Tyr Leu 
        435                 440                 445             


Lys Glu Asp Gly Thr Ile Gln Ile Gly Thr Gln Asp Cys Ile Val Thr 
    450                 455                 460                 


Pro Val Gly Gly Arg Lys Val Thr Gln Pro Lys Ala His Phe Leu His 
465                 470                 475                 480 


Thr Gln Ile Ile Gln Lys Lys Asp Pro Asn Asp Thr Arg Asp His Ile 
                485                 490                 495     


Val Gln Thr Glu Leu Ala Val Ala Gly Asn Leu Trp His Gly Met Asp 
            500                 505                 510         


Glu Leu Tyr Lys Gly Ser Gly His His His His His His 
        515                 520                 525 


<210>  8
<211>  525
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-RBN

<400>  8

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    130                 135                 140                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            180                 185                 190         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        195                 200                 205             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Ser 
                245                 250                 255     


Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Gly Ser Gly Val Ser Lys Gly Glu Glu Asp Asn Met 
        275                 280                 285             


Ala Ser Leu Pro Ala Thr His Glu Leu His Ile Phe Gly Ser Ile Asn 
    290                 295                 300                 


Gly Val Asp Phe Asp Met Val Gly Gln Gly Thr Gly Asn Pro Asn Asp 
305                 310                 315                 320 


Gly Tyr Glu Glu Leu Asn Leu Lys Ser Thr Lys Gly Asp Leu Gln Phe 
                325                 330                 335     


Ser Pro Trp Ile Leu Val Pro His Ile Gly Tyr Gly Phe His Gln Tyr 
            340                 345                 350         


Leu Pro Tyr Pro Asp Gly Met Ser Pro Phe Gln Ala Ala Met Val Asp 
        355                 360                 365             


Gly Ser Gly Tyr Gln Val His Arg Thr Met Gln Phe Glu Asp Gly Ala 
    370                 375                 380                 


Ser Leu Thr Val Asn Tyr Arg Tyr Thr Tyr Glu Gly Ser His Ile Lys 
385                 390                 395                 400 


Gly Glu Ala Gln Val Lys Gly Thr Gly Phe Pro Ala Asp Gly Pro Val 
                405                 410                 415     


Met Thr Asn Ser Leu Thr Ala Ala Asp Trp Cys Arg Ser Lys Lys Thr 
            420                 425                 430         


Tyr Pro Asn Asp Lys Thr Ile Ile Ser Thr Phe Lys Trp Ser Tyr Thr 
        435                 440                 445             


Thr Gly Asn Gly Lys Arg Tyr Arg Ser Thr Ala Arg Thr Thr Tyr Thr 
    450                 455                 460                 


Phe Ala Lys Pro Met Ala Ala Asn Tyr Leu Lys Asn Gln Pro Met Tyr 
465                 470                 475                 480 


Val Phe Arg Lys Thr Glu Leu Lys His Ser Lys Thr Glu Leu Asn Phe 
                485                 490                 495     


Lys Glu Trp Gln Lys Ala Phe Thr Asp Val Met Gly Met Asp Glu Leu 
            500                 505                 510         


Tyr Lys Ser Leu Glu His His His His His His His His 
        515                 520                 525 


<210>  9
<211>  1578
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-RBG

<400>  9
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg      120

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc      180

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc      240

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg      300

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc      360

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc      420

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg      480

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc      540

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac      600

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc      660

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag      720

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcagatc tggcggcgga      780

ggaagcggag gaggtggcag cggtggcggt ggctccggcg gaggtggatc cggcgtgagc      840

aagggcgagg aggcatctgg cagagccctg ttccagtacc ccatgaccag caagatcgag      900

ctgaacggcg agatcaacgg caagaaattc aaggtggccg gcgagggctt cacccccagc      960

agcggcagat tcaacatgca cgcctactgc accaccggcg acctgcctat gagctgggtc     1020

gtgattgcca gccccctcca gtacggcttc cacatgttcg cccactaccc cgaggacatc     1080

acacactttt tccaggaatg cttccccggc agctacaccc tggaccggac cctgagaatg     1140

gaaggcgacg gcaccctgac cacccaccac gagtacagcc tggaggacgg ctgcgtgacc     1200

tccaagacca ccctgaatgc cagcggcttc gaccctaagg gcgccaccat gaccaagagc     1260

ttcgtgaaac aactgcctaa cgaggtgaag atcacccccc acggccccaa cggcatcaga     1320

ctgaccagca ccgtgctgta cctgaaggag gatggcacca tccagatcgg cacccaggac     1380

tgcatcgtga cccctgtggg cggaaggaaa gtgacccagc ccaaggccca cttcctgcac     1440

acccagatca tccagaagaa ggaccccaac gacacccggg accacatcgt gcagacagaa     1500

ctggccgtgg ccggcaatct gtggcacggc atggacgagc tgtacaaggg tagcggtcac     1560

caccaccacc accactga                                                   1578


<210>  10
<211>  1578
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-RBN

<400>  10
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg      120

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc      180

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc      240

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg      300

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc      360

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc      420

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg      480

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc      540

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac      600

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc      660

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag      720

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcagcgc tagcggcggc      780

ggaggaagcg gaggaggtgg cagcggtggc ggtggctccg gcggaggtgg atccggcgtg      840

agcaagggcg aggaggacaa catggccagc ctgcccgcca cccacgagct gcacatcttc      900

ggcagcatca acggcgtgga cttcgacatg gtgggccagg gcaccggcaa ccccaacgac      960

ggctacgagg agctgaacct gaagagcacc aagggcgacc tgcagttcag cccctggatc     1020

ttagtgcccc acatcggcta cggcttccac cagtacctgc cctaccccga cggcatgagc     1080

cccttccagg ccgccatggt ggacggcagc ggctaccagg tgcaccgcac catgcagttc     1140

gaggacggcg ccagcctgac cgtgaactac cgctacacct acgagggcag ccacatcaag     1200

ggcgaggccc aggtgaaggg caccggcttc cccgccgacg gccccgtgat gaccaacagc     1260

ctgaccgccg ccgactggtg ccgcagcaag aagacctacc ccaacgacaa gaccatcatc     1320

agcaccttca agtggagcta caccaccggc aacggcaagc gctaccgcag caccgcccgc     1380

accacctaca ccttcgccaa gcccatggcc gccaactacc tgaagaacca gcccatgtac     1440

gtgttccgca agaccgagct gaagcacagc aagaccgagc tgaacttcaa ggagtggcag     1500

aaggccttca ccgacgtgat gggcatggac gagctgtaca agagcctcga gcatcaccac     1560

caccaccacc accactaa                                                   1578


<210>  11
<211>  795
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-RBD-His

<400>  11
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg      120

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc      180

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc      240

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg      300

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc      360

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc      420

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg      480

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc      540

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac      600

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc      660

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag      720

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcagatc tggtcaccac      780

caccaccacc actga                                                       795


<210>  12
<211>  264
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-RBD-His

<400>  12

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    130                 135                 140                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            180                 185                 190         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        195                 200                 205             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Arg 
                245                 250                 255     


Ser Gly His His His His His His 
            260                 


<210>  13
<211>  524
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV1-RBG

<400>  13

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Asn Phe Arg Val Val Pro Ser Gly Asp Val Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Lys Phe Pro Ser Val Tyr Ala Trp Glu Arg Lys Lys Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Phe Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Ala Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Ser Asn Val Tyr Ala Asp Ser Phe Val Val Lys Gly Asp Asp Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Val Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Met Gly Cys Val Leu Ala Trp Asn Thr Arg 
    130                 135                 140                 


Asn Ile Asp Ala Thr Ser Thr Gly Asn Tyr Asn Tyr Lys Tyr Arg Tyr 
145                 150                 155                 160 


Leu Arg His Gly Lys Leu Arg Pro Phe Glu Arg Asp Ile Ser Asn Val 
                165                 170                 175     


Pro Phe Ser Pro Asp Gly Lys Pro Cys Thr Pro Pro Ala Leu Asn Cys 
            180                 185                 190         


Tyr Trp Pro Leu Asn Asp Tyr Gly Phe Tyr Thr Thr Thr Gly Ile Gly 
        195                 200                 205             


Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn Ala 
    210                 215                 220                 


Pro Ala Thr Val Cys Gly Pro Lys Leu Ser Thr Asp Leu Ile Lys Asn 
225                 230                 235                 240 


Gln Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Arg Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            260                 265                 270         


Gly Gly Gly Ser Gly Val Ser Lys Gly Glu Glu Ala Ser Gly Arg Ala 
        275                 280                 285             


Leu Phe Gln Tyr Pro Met Thr Ser Lys Ile Glu Leu Asn Gly Glu Ile 
    290                 295                 300                 


Asn Gly Lys Lys Phe Lys Val Ala Gly Glu Gly Phe Thr Pro Ser Ser 
305                 310                 315                 320 


Gly Arg Phe Asn Met His Ala Tyr Cys Thr Thr Gly Asp Leu Pro Met 
                325                 330                 335     


Ser Trp Val Val Ile Ala Ser Pro Leu Gln Tyr Gly Phe His Met Phe 
            340                 345                 350         


Ala His Tyr Pro Glu Asp Ile Thr His Phe Phe Gln Glu Cys Phe Pro 
        355                 360                 365             


Gly Ser Tyr Thr Leu Asp Arg Thr Leu Arg Met Glu Gly Asp Gly Thr 
    370                 375                 380                 


Leu Thr Thr His His Glu Tyr Ser Leu Glu Asp Gly Cys Val Thr Ser 
385                 390                 395                 400 


Lys Thr Thr Leu Asn Ala Ser Gly Phe Asp Pro Lys Gly Ala Thr Met 
                405                 410                 415     


Thr Lys Ser Phe Val Lys Gln Leu Pro Asn Glu Val Lys Ile Thr Pro 
            420                 425                 430         


His Gly Pro Asn Gly Ile Arg Leu Thr Ser Thr Val Leu Tyr Leu Lys 
        435                 440                 445             


Glu Asp Gly Thr Ile Gln Ile Gly Thr Gln Asp Cys Ile Val Thr Pro 
    450                 455                 460                 


Val Gly Gly Arg Lys Val Thr Gln Pro Lys Ala His Phe Leu His Thr 
465                 470                 475                 480 


Gln Ile Ile Gln Lys Lys Asp Pro Asn Asp Thr Arg Asp His Ile Val 
                485                 490                 495     


Gln Thr Glu Leu Ala Val Ala Gly Asn Leu Trp His Gly Met Asp Glu 
            500                 505                 510         


Leu Tyr Lys Gly Ser Gly His His His His His His 
        515                 520                 


<210>  14
<211>  1575
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV1-RBG

<400>  14
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

agcaacttca gggtggtgcc atctggagat gtggtgaggt ttccaaacat caccaacctg      120

tgtccatttg gagaggtgtt caatgccacc aagtttccat ctgtctatgc ctgggagagg      180

aagaagatta gcaactgtgt ggctgactac tctgtgctct acaacagcac cttcttcagc      240

accttcaagt gttatggagt gtctgccacc aaactgaatg acctgtgttt cagcaatgtc      300

tatgctgact cctttgtggt gaagggagat gatgtgagac agattgcccc tggacaaaca      360

ggagtgattg ctgactacaa ctacaaactg cctgatgact ttatgggctg tgtgctggct      420

tggaacacca ggaacattga tgccaccagc acaggcaact acaactacaa atacagatac      480

ctgagacatg gcaaactgag accatttgag agggacatca gcaatgtgcc attcagccct      540

gatggcaagc catgtactcc tcctgccctg aactgttact ggccactgaa tgactatggc      600

ttctacacca ccacaggcat tggctaccaa ccatacaggg tggtggtgct gtcctttgaa      660

ctgctgaatg cccctgccac agtgtgtgga ccaaaactga gcacagacct gattaagaac      720

cagtgtgtga acttcaactt caatggactg acaggcacag gaagatctgg cggcggagga      780

agcggaggag gtggcagcgg tggcggtggc tccggcggag gtggatccgg cgtgagcaag      840

ggcgaggagg catctggcag agccctgttc cagtacccca tgaccagcaa gatcgagctg      900

aacggcgaga tcaacggcaa gaaattcaag gtggccggcg agggcttcac ccccagcagc      960

ggcagattca acatgcacgc ctactgcacc accggcgacc tgcctatgag ctgggtcgtg     1020

attgccagcc ccctccagta cggcttccac atgttcgccc actaccccga ggacatcaca     1080

cactttttcc aggaatgctt ccccggcagc tacaccctgg accggaccct gagaatggaa     1140

ggcgacggca ccctgaccac ccaccacgag tacagcctgg aggacggctg cgtgacctcc     1200

aagaccaccc tgaatgccag cggcttcgac cctaagggcg ccaccatgac caagagcttc     1260

gtgaaacaac tgcctaacga ggtgaagatc accccccacg gccccaacgg catcagactg     1320

accagcaccg tgctgtacct gaaggaggat ggcaccatcc agatcggcac ccaggactgc     1380

atcgtgaccc ctgtgggcgg aaggaaagtg acccagccca aggcccactt cctgcacacc     1440

cagatcatcc agaagaagga ccccaacgac acccgggacc acatcgtgca gacagaactg     1500

gccgtggccg gcaatctgtg gcacggcatg gacgagctgt acaagggtag cggtcaccac     1560

caccaccacc actga                                                      1575


<210>  15
<211>  542
<212>  PRT
<213>  ˹

<220>
<223>  MERS-RBG

<400>  15

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Ser Phe Glu Ala Lys Pro Ser Gly Ser Val Val 
            20                  25                  30          


Glu Gln Ala Glu Gly Val Glu Cys Asp Phe Ser Pro Leu Leu Ser Gly 
        35                  40                  45              


Thr Pro Pro Gln Val Tyr Asn Phe Lys Arg Leu Val Phe Thr Asn Cys 
    50                  55                  60                  


Asn Tyr Asn Leu Thr Lys Leu Leu Ser Leu Phe Ser Val Asn Asp Phe 
65                  70                  75                  80  


Thr Cys Ser Gln Ile Ser Pro Ala Ala Ile Ala Ser Asn Cys Tyr Ser 
                85                  90                  95      


Ser Leu Ile Leu Asp Tyr Phe Ser Tyr Pro Leu Ser Met Lys Ser Asp 
            100                 105                 110         


Leu Ser Val Ser Ser Ala Gly Pro Ile Ser Gln Phe Asn Tyr Lys Gln 
        115                 120                 125             


Ser Phe Ser Asn Pro Thr Cys Leu Ile Leu Ala Thr Val Pro His Asn 
    130                 135                 140                 


Leu Thr Thr Ile Thr Lys Pro Leu Lys Tyr Ser Tyr Ile Asn Lys Cys 
145                 150                 155                 160 


Ser Arg Leu Leu Ser Asp Asp Arg Thr Glu Val Pro Gln Leu Val Asn 
                165                 170                 175     


Ala Asn Gln Tyr Ser Pro Cys Val Ser Ile Val Pro Ser Thr Val Trp 
            180                 185                 190         


Glu Asp Gly Asp Tyr Tyr Arg Lys Gln Leu Ser Pro Leu Glu Gly Gly 
        195                 200                 205             


Gly Trp Leu Val Ala Ser Gly Ser Thr Val Ala Met Thr Glu Gln Leu 
    210                 215                 220                 


Gln Met Gly Phe Gly Ile Thr Val Gln Tyr Gly Thr Asp Thr Asn Ser 
225                 230                 235                 240 


Val Cys Pro Lys Leu Glu Phe Ala Asn Asp Thr Lys Ile Ala Ser Gln 
                245                 250                 255     


Leu Gly Asn Cys Val Glu Tyr Ser Leu Tyr Gly Val Ser Gly Arg Gly 
            260                 265                 270         


Arg Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        275                 280                 285             


Ser Gly Gly Gly Gly Ser Gly Val Ser Lys Gly Glu Glu Ala Ser Gly 
    290                 295                 300                 


Arg Ala Leu Phe Gln Tyr Pro Met Thr Ser Lys Ile Glu Leu Asn Gly 
305                 310                 315                 320 


Glu Ile Asn Gly Lys Lys Phe Lys Val Ala Gly Glu Gly Phe Thr Pro 
                325                 330                 335     


Ser Ser Gly Arg Phe Asn Met His Ala Tyr Cys Thr Thr Gly Asp Leu 
            340                 345                 350         


Pro Met Ser Trp Val Val Ile Ala Ser Pro Leu Gln Tyr Gly Phe His 
        355                 360                 365             


Met Phe Ala His Tyr Pro Glu Asp Ile Thr His Phe Phe Gln Glu Cys 
    370                 375                 380                 


Phe Pro Gly Ser Tyr Thr Leu Asp Arg Thr Leu Arg Met Glu Gly Asp 
385                 390                 395                 400 


Gly Thr Leu Thr Thr His His Glu Tyr Ser Leu Glu Asp Gly Cys Val 
                405                 410                 415     


Thr Ser Lys Thr Thr Leu Asn Ala Ser Gly Phe Asp Pro Lys Gly Ala 
            420                 425                 430         


Thr Met Thr Lys Ser Phe Val Lys Gln Leu Pro Asn Glu Val Lys Ile 
        435                 440                 445             


Thr Pro His Gly Pro Asn Gly Ile Arg Leu Thr Ser Thr Val Leu Tyr 
    450                 455                 460                 


Leu Lys Glu Asp Gly Thr Ile Gln Ile Gly Thr Gln Asp Cys Ile Val 
465                 470                 475                 480 


Thr Pro Val Gly Gly Arg Lys Val Thr Gln Pro Lys Ala His Phe Leu 
                485                 490                 495     


His Thr Gln Ile Ile Gln Lys Lys Asp Pro Asn Asp Thr Arg Asp His 
            500                 505                 510         


Ile Val Gln Thr Glu Leu Ala Val Ala Gly Asn Leu Trp His Gly Met 
        515                 520                 525             


Asp Glu Leu Tyr Lys Gly Ser Gly His His His His His His 
    530                 535                 540         


<210>  16
<211>  1629
<212>  DNA
<213>  ˹

<220>
<223>  MERS-RBG

<400>  16
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

tcctcctttg aggctaagcc atctggctct gtggtggaac aggctgaggg agtggagtgt      120

gacttcagcc cactgctgtc tggcacacct ccacaggtct acaacttcaa gagactggtg      180

ttcaccaact gtaactacaa cctgaccaaa ctgctgtccc tgttctctgt gaatgacttc      240

acttgtagcc agattagccc tgctgccatt gccagcaact gttactcctc cctgattctg      300

gactacttct cctacccact gagtatgaag tctgacctgt ctgtgtcctc tgctggacca      360

atcagccagt tcaactacaa gcagtccttc agcaacccaa cttgtctgat tctggctaca      420

gtgccacaca acctgaccac catcaccaag ccactgaaat actcctacat caacaagtgt      480

agcagactgc tgtctgatga caggacagag gtgccacaac tagtgaatgc caaccaatac      540

agcccatgtg tgagcattgt gccaagcaca gtgtgggagg atggagacta ctacaggaag      600

caacttagcc cattggaggg aggaggctgg ctggtggcat ctggcagcac agtggctatg      660

acagaacaac tccaaatggg ctttggcatc acagtccaat atggcacaga caccaactct      720

gtgtgtccaa aattggagtt tgccaatgac accaagattg ccagccaact tggcaactgt      780

gtggaatact ccctctatgg agtgtctggc aggggaagat ctggcggcgg aggaagcgga      840

ggaggtggca gcggtggcgg tggctccggc ggaggtggat ccggcgtgag caagggcgag      900

gaggcatctg gcagagccct gttccagtac cccatgacca gcaagatcga gctgaacggc      960

gagatcaacg gcaagaaatt caaggtggcc ggcgagggct tcacccccag cagcggcaga     1020

ttcaacatgc acgcctactg caccaccggc gacctgccta tgagctgggt cgtgattgcc     1080

agccccctcc agtacggctt ccacatgttc gcccactacc ccgaggacat cacacacttt     1140

ttccaggaat gcttccccgg cagctacacc ctggaccgga ccctgagaat ggaaggcgac     1200

ggcaccctga ccacccacca cgagtacagc ctggaggacg gctgcgtgac ctccaagacc     1260

accctgaatg ccagcggctt cgaccctaag ggcgccacca tgaccaagag cttcgtgaaa     1320

caactgccta acgaggtgaa gatcaccccc cacggcccca acggcatcag actgaccagc     1380

accgtgctgt acctgaagga ggatggcacc atccagatcg gcacccagga ctgcatcgtg     1440

acccctgtgg gcggaaggaa agtgacccag cccaaggccc acttcctgca cacccagatc     1500

atccagaaga aggaccccaa cgacacccgg gaccacatcg tgcagacaga actggccgtg     1560

gccggcaatc tgtggcacgg catggacgag ctgtacaagg gtagcggtca ccaccaccac     1620

caccactga                                                             1629


<210>  17
<211>  617
<212>  PRT
<213>  ˹

<220>
<223>  HKU1-RBG

<400>  17

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val His 
            20                  25                  30          


Arg Arg Ile Pro Asp Leu Pro Asp Cys Asp Ile Asp Lys Trp Leu Asn 
        35                  40                  45              


Asn Phe Asn Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Ile Phe Ser 
    50                  55                  60                  


Asn Cys Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Thr Asp 
65                  70                  75                  80  


Ser Phe Ser Cys Asn Asn Phe Asp Glu Ser Lys Ile Tyr Gly Ser Cys 
                85                  90                  95      


Phe Lys Ser Ile Val Leu Asp Lys Phe Ala Ile Pro Asn Ser Arg Arg 
            100                 105                 110         


Ser Asp Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn Tyr 
        115                 120                 125             


Lys Ile Asp Thr Thr Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu Pro 
    130                 135                 140                 


Ala Ile Asn Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn Arg 
145                 150                 155                 160 


Arg Tyr Gly Phe Asn Asn Phe Asn Leu Ser Ser His Ser Val Val Tyr 
                165                 170                 175     


Ser Arg Tyr Cys Phe Ser Val Asn Asn Thr Phe Cys Pro Cys Ala Lys 
            180                 185                 190         


Pro Ser Phe Ala Ser Ser Cys Lys Ser His Lys Pro Pro Ser Ala Ser 
        195                 200                 205             


Cys Pro Ile Gly Thr Asn Tyr Arg Ser Cys Glu Ser Thr Thr Val Leu 
    210                 215                 220                 


Asp His Thr Asp Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile Thr 
225                 230                 235                 240 


Ala Tyr Asp Pro Arg Ser Cys Ser Gln Lys Lys Ser Leu Val Gly Val 
                245                 250                 255     


Gly Glu His Cys Ala Gly Phe Gly Val Asp Glu Glu Lys Cys Gly Val 
            260                 265                 270         


Leu Asp Gly Ser Tyr Asn Val Ser Cys Leu Cys Ser Thr Asp Ala Phe 
        275                 280                 285             


Leu Gly Trp Ser Tyr Asp Thr Cys Val Ser Asn Asn Arg Cys Asn Ile 
    290                 295                 300                 


Phe Ser Asn Phe Ile Leu Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser 
305                 310                 315                 320 


Asn Asp Leu Leu Gln Pro Asn Thr Glu Val Phe Thr Asp Val Cys Val 
                325                 330                 335     


Asp Tyr Asp Leu Tyr Gly Ile Thr Gly Gln Gly Arg Ser Gly Gly Gly 
            340                 345                 350         


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        355                 360                 365             


Ser Gly Val Ser Lys Gly Glu Glu Ala Ser Gly Arg Ala Leu Phe Gln 
    370                 375                 380                 


Tyr Pro Met Thr Ser Lys Ile Glu Leu Asn Gly Glu Ile Asn Gly Lys 
385                 390                 395                 400 


Lys Phe Lys Val Ala Gly Glu Gly Phe Thr Pro Ser Ser Gly Arg Phe 
                405                 410                 415     


Asn Met His Ala Tyr Cys Thr Thr Gly Asp Leu Pro Met Ser Trp Val 
            420                 425                 430         


Val Ile Ala Ser Pro Leu Gln Tyr Gly Phe His Met Phe Ala His Tyr 
        435                 440                 445             


Pro Glu Asp Ile Thr His Phe Phe Gln Glu Cys Phe Pro Gly Ser Tyr 
    450                 455                 460                 


Thr Leu Asp Arg Thr Leu Arg Met Glu Gly Asp Gly Thr Leu Thr Thr 
465                 470                 475                 480 


His His Glu Tyr Ser Leu Glu Asp Gly Cys Val Thr Ser Lys Thr Thr 
                485                 490                 495     


Leu Asn Ala Ser Gly Phe Asp Pro Lys Gly Ala Thr Met Thr Lys Ser 
            500                 505                 510         


Phe Val Lys Gln Leu Pro Asn Glu Val Lys Ile Thr Pro His Gly Pro 
        515                 520                 525             


Asn Gly Ile Arg Leu Thr Ser Thr Val Leu Tyr Leu Lys Glu Asp Gly 
    530                 535                 540                 


Thr Ile Gln Ile Gly Thr Gln Asp Cys Ile Val Thr Pro Val Gly Gly 
545                 550                 555                 560 


Arg Lys Val Thr Gln Pro Lys Ala His Phe Leu His Thr Gln Ile Ile 
                565                 570                 575     


Gln Lys Lys Asp Pro Asn Asp Thr Arg Asp His Ile Val Gln Thr Glu 
            580                 585                 590         


Leu Ala Val Ala Gly Asn Leu Trp His Gly Met Asp Glu Leu Tyr Lys 
        595                 600                 605             


Gly Ser Gly His His His His His His 
    610                 615         


<210>  18
<211>  1854
<212>  DNA
<213>  ˹

<220>
<223>  HKU1-RBG

<400>  18
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

tctggcttca cagtgaagcc tgtggccaca gtgcacagga ggatacctga cctgcctgac      120

tgtgacattg acaagtggct gaacaacttc aatgtgccat cccccctgaa ctgggagagg      180

aagatcttct ccaactgcaa cttcaacctg tccaccctgc tgaggctggt gcacacagac      240

tccttctcct gcaacaactt tgatgagtcc aagatctatg gctcctgctt caagtccatt      300

gtgctggaca agtttgccat ccccaactcc aggaggtctg acctgcagct gggctcctct      360

ggcttcctgc agtcctccaa ctacaagatt gacaccacct cctcctcctg ccagctgtac      420

tactccctgc ctgccatcaa tgtgaccatc aacaactaca acccatcctc ctggaacagg      480

aggtatggct tcaacaactt caacctgtcc tcccactctg tggtctactc caggtactgc      540

ttctctgtga acaacacctt ctgcccatgt gccaagccat cctttgcctc ctcctgcaag      600

tcccacaagc ccccatctgc ctcctgcccc attggcacca actacaggtc ctgtgagtcc      660

accacagtgc tggaccacac agactggtgc aggtgctcct gcctgcctga ccccatcaca      720

gcctatgacc ccaggtcctg ctcccagaag aagtccctgg tgggcgtggg cgagcactgt      780

gctggctttg gcgtggatga ggagaagtgt ggcgtgctgg atggctccta caatgtctcc      840

tgcctgtgct ccacagatgc cttcctgggc tggtcctatg acacctgtgt ctccaacaac      900

aggtgcaaca tcttctccaa cttcatcctg aatggcatca actctggcac cacctgctcc      960

aatgacctgc tgcagcccaa cacagaggtc ttcacagatg tctgtgtgga ctatgacctg     1020

tatggcatca caggccaggg cagatctggc ggcggaggaa gcggaggagg tggcagcggt     1080

ggcggtggct ccggcggagg tggatccggc gtgagcaagg gcgaggaggc atctggcaga     1140

gccctgttcc agtaccccat gaccagcaag atcgagctga acggcgagat caacggcaag     1200

aaattcaagg tggccggcga gggcttcacc cccagcagcg gcagattcaa catgcacgcc     1260

tactgcacca ccggcgacct gcctatgagc tgggtcgtga ttgccagccc cctccagtac     1320

ggcttccaca tgttcgccca ctaccccgag gacatcacac actttttcca ggaatgcttc     1380

cccggcagct acaccctgga ccggaccctg agaatggaag gcgacggcac cctgaccacc     1440

caccacgagt acagcctgga ggacggctgc gtgacctcca agaccaccct gaatgccagc     1500

ggcttcgacc ctaagggcgc caccatgacc aagagcttcg tgaaacaact gcctaacgag     1560

gtgaagatca ccccccacgg ccccaacggc atcagactga ccagcaccgt gctgtacctg     1620

aaggaggatg gcaccatcca gatcggcacc caggactgca tcgtgacccc tgtgggcgga     1680

aggaaagtga cccagcccaa ggcccacttc ctgcacaccc agatcatcca gaagaaggac     1740

cccaacgaca cccgggacca catcgtgcag acagaactgg ccgtggccgg caatctgtgg     1800

cacggcatgg acgagctgta caagggtagc ggtcaccacc accaccacca ctga           1854


<210>  19
<211>  525
<212>  PRT
<213>  ˹

<220>
<223>  RaTG13-RBG

<400>  19

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Ser Asn Phe Arg Val Gln Pro Thr Asp Ser Ile Val 
            20                  25                  30          


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        35                  40                  45              


Ala Thr Thr Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    50                  55                  60                  


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Thr Ser Phe Ser 
65                  70                  75                  80  


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                85                  90                  95      


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Thr Gly Asp Glu Val 
            100                 105                 110         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        115                 120                 125             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Lys 
    130                 135                 140                 


His Ile Asp Ala Lys Glu Gly Gly Asn Phe Asn Tyr Leu Tyr Arg Leu 
145                 150                 155                 160 


Phe Arg Lys Ala Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                165                 170                 175     


Ile Tyr Gln Ala Gly Ser Lys Pro Cys Asn Gly Gln Thr Gly Leu Asn 
            180                 185                 190         


Cys Tyr Tyr Pro Leu Tyr Arg Tyr Gly Phe Tyr Pro Thr Asp Gly Val 
        195                 200                 205             


Gly His Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu Asn 
    210                 215                 220                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
225                 230                 235                 240 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Arg 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Val Ser Lys Gly Glu Glu Ala Ser Gly Arg 
        275                 280                 285             


Ala Leu Phe Gln Tyr Pro Met Thr Ser Lys Ile Glu Leu Asn Gly Glu 
    290                 295                 300                 


Ile Asn Gly Lys Lys Phe Lys Val Ala Gly Glu Gly Phe Thr Pro Ser 
305                 310                 315                 320 


Ser Gly Arg Phe Asn Met His Ala Tyr Cys Thr Thr Gly Asp Leu Pro 
                325                 330                 335     


Met Ser Trp Val Val Ile Ala Ser Pro Leu Gln Tyr Gly Phe His Met 
            340                 345                 350         


Phe Ala His Tyr Pro Glu Asp Ile Thr His Phe Phe Gln Glu Cys Phe 
        355                 360                 365             


Pro Gly Ser Tyr Thr Leu Asp Arg Thr Leu Arg Met Glu Gly Asp Gly 
    370                 375                 380                 


Thr Leu Thr Thr His His Glu Tyr Ser Leu Glu Asp Gly Cys Val Thr 
385                 390                 395                 400 


Ser Lys Thr Thr Leu Asn Ala Ser Gly Phe Asp Pro Lys Gly Ala Thr 
                405                 410                 415     


Met Thr Lys Ser Phe Val Lys Gln Leu Pro Asn Glu Val Lys Ile Thr 
            420                 425                 430         


Pro His Gly Pro Asn Gly Ile Arg Leu Thr Ser Thr Val Leu Tyr Leu 
        435                 440                 445             


Lys Glu Asp Gly Thr Ile Gln Ile Gly Thr Gln Asp Cys Ile Val Thr 
    450                 455                 460                 


Pro Val Gly Gly Arg Lys Val Thr Gln Pro Lys Ala His Phe Leu His 
465                 470                 475                 480 


Thr Gln Ile Ile Gln Lys Lys Asp Pro Asn Asp Thr Arg Asp His Ile 
                485                 490                 495     


Val Gln Thr Glu Leu Ala Val Ala Gly Asn Leu Trp His Gly Met Asp 
            500                 505                 510         


Glu Leu Tyr Lys Gly Ser Gly His His His His His His 
        515                 520                 525 


<210>  20
<211>  1578
<212>  DNA
<213>  ˹

<220>
<223>  RaTG13-RBG

<400>  20
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

agcaacttcc gcgtgcagcc caccgacagc atcgtgcgct tccccaacat caccaacctg      120

tgccccttcg gcgaggtgtt caacgccacc accttcgcca gcgtgtacgc ctggaaccgc      180

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcac cagcttcagc      240

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg      300

tacgccgaca gcttcgtgat caccggcgac gaggtgcgcc agatcgcccc cggccagacc      360

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc      420

tggaacagca agcacatcga cgccaaggag ggcggcaact tcaactacct gtaccgcctg      480

ttccgcaagg ccaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc      540

ggcagcaagc cctgcaacgg ccagaccggc ctgaactgct actaccccct gtaccgctac      600

ggcttctacc ccaccgacgg cgtgggccac cagccctacc gcgtggtggt gctgagcttc      660

gagctgctga acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag      720

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcagatc tggcggcgga      780

ggaagcggag gaggtggcag cggtggcggt ggctccggcg gaggtggatc cggcgtgagc      840

aagggcgagg aggcatctgg cagagccctg ttccagtacc ccatgaccag caagatcgag      900

ctgaacggcg agatcaacgg caagaaattc aaggtggccg gcgagggctt cacccccagc      960

agcggcagat tcaacatgca cgcctactgc accaccggcg acctgcctat gagctgggtc     1020

gtgattgcca gccccctcca gtacggcttc cacatgttcg cccactaccc cgaggacatc     1080

acacactttt tccaggaatg cttccccggc agctacaccc tggaccggac cctgagaatg     1140

gaaggcgacg gcaccctgac cacccaccac gagtacagcc tggaggacgg ctgcgtgacc     1200

tccaagacca ccctgaatgc cagcggcttc gaccctaagg gcgccaccat gaccaagagc     1260

ttcgtgaaac aactgcctaa cgaggtgaag atcacccccc acggccccaa cggcatcaga     1320

ctgaccagca ccgtgctgta cctgaaggag gatggcacca tccagatcgg cacccaggac     1380

tgcatcgtga cccctgtggg cggaaggaaa gtgacccagc ccaaggccca cttcctgcac     1440

acccagatca tccagaagaa ggaccccaac gacacccggg accacatcgt gcagacagaa     1500

ctggccgtgg ccggcaatct gtggcacggc atggacgagc tgtacaaggg tagcggtcac     1560

caccaccacc accactga                                                   1578


<210>  21
<211>  1192
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-Secd

<400>  21

Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
1               5                   10                  15      


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
            20                  25                  30          


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
        35                  40                  45              


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
    50                  55                  60                  


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
65                  70                  75                  80  


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
                85                  90                  95      


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
            100                 105                 110         


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
        115                 120                 125             


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
    130                 135                 140                 


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
145                 150                 155                 160 


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
                165                 170                 175     


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
            180                 185                 190         


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
        195                 200                 205             


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
    210                 215                 220                 


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
225                 230                 235                 240 


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
                245                 250                 255     


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
            260                 265                 270         


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
        275                 280                 285             


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
    290                 295                 300                 


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
305                 310                 315                 320 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
                325                 330                 335     


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
            340                 345                 350         


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
        355                 360                 365             


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
    370                 375                 380                 


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
385                 390                 395                 400 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
                405                 410                 415     


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
            420                 425                 430         


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
        435                 440                 445             


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
    450                 455                 460                 


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
465                 470                 475                 480 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
                485                 490                 495     


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
            500                 505                 510         


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
        515                 520                 525             


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
    530                 535                 540                 


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
545                 550                 555                 560 


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
                565                 570                 575     


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
            580                 585                 590         


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
        595                 600                 605             


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
    610                 615                 620                 


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
625                 630                 635                 640 


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
                645                 650                 655     


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser Ala Ser Ser Val 
            660                 665                 670         


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
        675                 680                 685             


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
    690                 695                 700                 


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
705                 710                 715                 720 


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
                725                 730                 735     


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
            740                 745                 750         


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
        755                 760                 765             


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
    770                 775                 780                 


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
785                 790                 795                 800 


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
                805                 810                 815     


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
            820                 825                 830         


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
        835                 840                 845             


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
    850                 855                 860                 


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
865                 870                 875                 880 


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
                885                 890                 895     


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
            900                 905                 910         


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
        915                 920                 925             


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
    930                 935                 940                 


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
945                 950                 955                 960 


Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val 
                965                 970                 975     


Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr Tyr 
            980                 985                 990         


Val Thr Gln Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
        995                 1000                 1005             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1010                 1015                 1020             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1025                 1030                 1035             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1040                 1045                 1050             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1055                 1060                 1065             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1070                 1075                 1080             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1085                 1090                 1095             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1100                 1105                 1110             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1115                 1120                 1125             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1130                 1135                 1140             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1145                 1150                 1155             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1160                 1165                 1170             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1175                 1180                 1185             


Gly Lys  Tyr Glu 
    1190         


<210>  22
<211>  3576
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-Secd

<400>  22
gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc       60

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      120

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      180

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      240

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      300

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      360

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      420

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      480

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      540

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      600

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      660

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      720

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      780

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      840

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      900

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg      960

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1020

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1080

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1140

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1200

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1260

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1320

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1380

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1440

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1500

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1560

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1620

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1680

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1740

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1800

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1860

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1920

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     1980

acccagacca acagccccgg tagcgcgagc tctgtggcca gccagagcat catcgcctac     2040

accatgagcc tgggcgccga gaacagcgtg gcctacagca acaacagcat cgccatcccc     2100

accaacttca ccatcagcgt gaccaccgag atcctgcccg tgagcatgac caagaccagc     2160

gtggactgca ccatgtacat ctgcggcgac agcaccgagt gcagcaacct gctgctgcag     2220

tacggcagct tctgcaccca gctgaaccgc gccctgaccg gcatcgccgt ggagcaggac     2280

aagaacaccc aggaggtgtt cgcccaggtg aagcagatat acaagacccc ccccatcaag     2340

gacttcggcg gcttcaactt cagccagatc ctgcccgacc ccagcaagcc cagcaagcgc     2400

agcttcatcg aggacctgct gttcaacaag gtgaccctgg ccgacgccgg cttcatcaag     2460

cagtacggcg actgcctggg cgacatcgcc gcccgcgacc tgatctgcgc ccagaagttc     2520

aacggcctga ccgtgctgcc ccccctgctg accgacgaga tgatcgccca gtacaccagc     2580

gccctgctgg ccggcaccat caccagcggc tggaccttcg gcgccggcgc cgccctgcag     2640

atccccttcg ccatgcagat ggcctaccgc ttcaacggca tcggcgtgac ccagaacgtg     2700

ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg caagatccag     2760

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc aggacgtggt gaaccagaac     2820

gcccaggccc tgaacaccct ggtgaagcag ctgagcagca acttcggcgc catcagcagc     2880

gtgctgaacg acatcctgag ccgcctggac aaggtggagg ccgaggtgca gatcgaccgc     2940

ctgatcaccg gccgcctgca gagcctgcag acctacgtga cccagcagct gatccgcgcc     3000

gccgagatcc gcgccagcgc caacctggcc gccaccaaga tgagcgagtg cgtgctgggc     3060

cagagcaagc gcgtggactt ctgcggcaag ggctaccacc tgatgagctt cccccagagc     3120

gccccccacg gcgtggtgtt cctgcacgtg acctacgtgc ccgcccagga gaagaacttc     3180

accaccgccc ccgccatctg ccacgacggc aaggcccact tcccccgcga gggcgtgttc     3240

gtgagcaacg gcacccactg gttcgtgacc cagcgcaact tctacgagcc ccagatcatc     3300

accaccgaca acaccttcgt gagcggcaac tgcgacgtgg tgatcggcat cgtgaacaac     3360

accgtgtacg accccctgca gcccgagctg gacagcttca aggaggagct ggacaagtac     3420

ttcaagaacc acaccagccc cgacgtggac ctgggcgaca tcagcggcat caacgctagc     3480

gtggtgaaca tccagaagga gatcgaccgc ctgaacgagg tggccaagaa cctgaacgag     3540

agcctgatcg acctgcagga gctgggcaag tacgag                               3576


<210>  23
<211>  81
<212>  DNA
<213>  ˹

<220>
<223>  TFD

<400>  23
tacatccccg aggccccccg cgacggccag gcctacgtgc gcaaggacgg cgagtgggtg       60

ctgctgagca ccttcctggg c                                                 81


<210>  24
<211>  4542
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-STG

<400>  24
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc      120

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      180

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      240

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      360

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      420

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      480

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      540

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      600

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      660

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      720

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      780

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      840

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      900

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      960

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg     1020

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1080

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1140

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1200

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1260

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1320

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1380

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1440

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1500

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1560

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1620

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1680

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1740

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1800

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1860

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1920

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1980

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     2040

acccagacca acagccccgg tagcgcgagc tctgtggcca gccagagcat catcgcctac     2100

accatgagcc tgggcgccga gaacagcgtg gcctacagca acaacagcat cgccatcccc     2160

accaacttca ccatcagcgt gaccaccgag atcctgcccg tgagcatgac caagaccagc     2220

gtggactgca ccatgtacat ctgcggcgac agcaccgagt gcagcaacct gctgctgcag     2280

tacggcagct tctgcaccca gctgaaccgc gccctgaccg gcatcgccgt ggagcaggac     2340

aagaacaccc aggaggtgtt cgcccaggtg aagcagatat acaagacccc ccccatcaag     2400

gacttcggcg gcttcaactt cagccagatc ctgcccgacc ccagcaagcc cagcaagcgc     2460

agcttcatcg aggacctgct gttcaacaag gtgaccctgg ccgacgccgg cttcatcaag     2520

cagtacggcg actgcctggg cgacatcgcc gcccgcgacc tgatctgcgc ccagaagttc     2580

aacggcctga ccgtgctgcc ccccctgctg accgacgaga tgatcgccca gtacaccagc     2640

gccctgctgg ccggcaccat caccagcggc tggaccttcg gcgccggcgc cgccctgcag     2700

atccccttcg ccatgcagat ggcctaccgc ttcaacggca tcggcgtgac ccagaacgtg     2760

ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg caagatccag     2820

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc aggacgtggt gaaccagaac     2880

gcccaggccc tgaacaccct ggtgaagcag ctgagcagca acttcggcgc catcagcagc     2940

gtgctgaacg acatcctgag ccgcctggac aaggtggagg ccgaggtgca gatcgaccgc     3000

ctgatcaccg gccgcctgca gagcctgcag acctacgtga cccagcagct gatccgcgcc     3060

gccgagatcc gcgccagcgc caacctggcc gccaccaaga tgagcgagtg cgtgctgggc     3120

cagagcaagc gcgtggactt ctgcggcaag ggctaccacc tgatgagctt cccccagagc     3180

gccccccacg gcgtggtgtt cctgcacgtg acctacgtgc ccgcccagga gaagaacttc     3240

accaccgccc ccgccatctg ccacgacggc aaggcccact tcccccgcga gggcgtgttc     3300

gtgagcaacg gcacccactg gttcgtgacc cagcgcaact tctacgagcc ccagatcatc     3360

accaccgaca acaccttcgt gagcggcaac tgcgacgtgg tgatcggcat cgtgaacaac     3420

accgtgtacg accccctgca gcccgagctg gacagcttca aggaggagct ggacaagtac     3480

ttcaagaacc acaccagccc cgacgtggac ctgggcgaca tcagcggcat caacgctagc     3540

gtggtgaaca tccagaagga gatcgaccgc ctgaacgagg tggccaagaa cctgaacgag     3600

agcctgatcg acctgcagga gctgggcaag tacgaattcg gttacatccc cgaggccccc     3660

cgcgacggcc aggcctacgt gcgcaaggac ggcgagtggg tgctgctgag caccttcctg     3720

ggcgtcgacg gcggcggagg aagcggagga ggtggcagcg gtggcggtgg ctccggcgga     3780

ggtggatccg gcgtgagcaa gggcgaggag gcatctggca gagccctgtt ccagtacccc     3840

atgaccagca agatcgagct gaacggcgag atcaacggca agaaattcaa ggtggccggc     3900

gagggcttca cccccagcag cggcagattc aacatgcacg cctactgcac caccggcgac     3960

ctgcctatga gctgggtcgt gattgccagc cccctccagt acggcttcca catgttcgcc     4020

cactaccccg aggacatcac acactttttc caggaatgct tccccggcag ctacaccctg     4080

gaccggaccc tgagaatgga aggcgacggc accctgacca cccaccacga gtacagcctg     4140

gaggacggct gcgtgacctc caagaccacc ctgaatgcca gcggcttcga ccctaagggc     4200

gccaccatga ccaagagctt cgtgaaacaa ctgcctaacg aggtgaagat caccccccac     4260

ggccccaacg gcatcagact gaccagcacc gtgctgtacc tgaaggagga tggcaccatc     4320

cagatcggca cccaggactg catcgtgacc cctgtgggcg gaaggaaagt gacccagccc     4380

aaggcccact tcctgcacac ccagatcatc cagaagaagg accccaacga cacccgggac     4440

cacatcgtgc agacagaact ggccgtggcc ggcaatctgt ggcacggcat ggacgagctg     4500

tacaagagcc tcgagcatca ccaccaccac caccaccact aa                        4542


<210>  25
<211>  4533
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-STN

<400>  25
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc      120

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      180

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      240

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      360

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      420

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      480

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      540

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      600

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      660

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      720

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      780

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      840

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      900

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      960

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg     1020

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1080

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1140

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1200

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1260

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1320

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1380

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1440

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1500

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1560

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1620

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1680

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1740

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1800

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1860

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1920

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1980

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     2040

acccagacca acagccccgg tagcgcgagc tctgtggcca gccagagcat catcgcctac     2100

accatgagcc tgggcgccga gaacagcgtg gcctacagca acaacagcat cgccatcccc     2160

accaacttca ccatcagcgt gaccaccgag atcctgcccg tgagcatgac caagaccagc     2220

gtggactgca ccatgtacat ctgcggcgac agcaccgagt gcagcaacct gctgctgcag     2280

tacggcagct tctgcaccca gctgaaccgc gccctgaccg gcatcgccgt ggagcaggac     2340

aagaacaccc aggaggtgtt cgcccaggtg aagcagatat acaagacccc ccccatcaag     2400

gacttcggcg gcttcaactt cagccagatc ctgcccgacc ccagcaagcc cagcaagcgc     2460

agcttcatcg aggacctgct gttcaacaag gtgaccctgg ccgacgccgg cttcatcaag     2520

cagtacggcg actgcctggg cgacatcgcc gcccgcgacc tgatctgcgc ccagaagttc     2580

aacggcctga ccgtgctgcc ccccctgctg accgacgaga tgatcgccca gtacaccagc     2640

gccctgctgg ccggcaccat caccagcggc tggaccttcg gcgccggcgc cgccctgcag     2700

atccccttcg ccatgcagat ggcctaccgc ttcaacggca tcggcgtgac ccagaacgtg     2760

ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg caagatccag     2820

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc aggacgtggt gaaccagaac     2880

gcccaggccc tgaacaccct ggtgaagcag ctgagcagca acttcggcgc catcagcagc     2940

gtgctgaacg acatcctgag ccgcctggac aaggtggagg ccgaggtgca gatcgaccgc     3000

ctgatcaccg gccgcctgca gagcctgcag acctacgtga cccagcagct gatccgcgcc     3060

gccgagatcc gcgccagcgc caacctggcc gccaccaaga tgagcgagtg cgtgctgggc     3120

cagagcaagc gcgtggactt ctgcggcaag ggctaccacc tgatgagctt cccccagagc     3180

gccccccacg gcgtggtgtt cctgcacgtg acctacgtgc ccgcccagga gaagaacttc     3240

accaccgccc ccgccatctg ccacgacggc aaggcccact tcccccgcga gggcgtgttc     3300

gtgagcaacg gcacccactg gttcgtgacc cagcgcaact tctacgagcc ccagatcatc     3360

accaccgaca acaccttcgt gagcggcaac tgcgacgtgg tgatcggcat cgtgaacaac     3420

accgtgtacg accccctgca gcccgagctg gacagcttca aggaggagct ggacaagtac     3480

ttcaagaacc acaccagccc cgacgtggac ctgggcgaca tcagcggcat caacgctagc     3540

gtggtgaaca tccagaagga gatcgaccgc ctgaacgagg tggccaagaa cctgaacgag     3600

agcctgatcg acctgcagga gctgggcaag tacgaattcg gttacatccc cgaggccccc     3660

cgcgacggcc aggcctacgt gcgcaaggac ggcgagtggg tgctgctgag caccttcctg     3720

ggcgtcgacg gcggcggagg aagcggagga ggtggcagcg gtggcggtgg ctccggcgga     3780

ggtggatccg gcgtgagcaa gggcgaggag gacaacatgg ccagcctgcc cgccacccac     3840

gagctgcaca tcttcggcag catcaacggc gtggacttcg acatggtggg ccagggcacc     3900

ggcaacccca acgacggcta cgaggagctg aacctgaaga gcaccaaggg cgacctgcag     3960

ttcagcccct ggatcttagt gccccacatc ggctacggct tccaccagta cctgccctac     4020

cccgacggca tgagcccctt ccaggccgcc atggtggacg gcagcggcta ccaggtgcac     4080

cgcaccatgc agttcgagga cggcgccagc ctgaccgtga actaccgcta cacctacgag     4140

ggcagccaca tcaagggcga ggcccaggtg aagggcaccg gcttccccgc cgacggcccc     4200

gtgatgacca acagcctgac cgccgccgac tggtgccgca gcaagaagac ctaccccaac     4260

gacaagacca tcatcagcac cttcaagtgg agctacacca ccggcaacgg caagcgctac     4320

cgcagcaccg cccgcaccac ctacaccttc gccaagccca tggccgccaa ctacctgaag     4380

aaccagccca tgtacgtgtt ccgcaagacc gagctgaagc acagcaagac cgagctgaac     4440

ttcaaggagt ggcagaaggc cttcaccgac gtgatgggca tggacgagct gtacaagagc     4500

ctcgagcatc accaccacca ccaccaccac taa                                  4533


<210>  26
<211>  1513
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-STG

<400>  26

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
            20                  25                  30          


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        35                  40                  45              


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    50                  55                  60                  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
65                  70                  75                  80  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
                85                  90                  95      


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
        115                 120                 125             


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
    130                 135                 140                 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
145                 150                 155                 160 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
                165                 170                 175     


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
            180                 185                 190         


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
        195                 200                 205             


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
    210                 215                 220                 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
                245                 250                 255     


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
            260                 265                 270         


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
        275                 280                 285             


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
    290                 295                 300                 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
305                 310                 315                 320 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
                325                 330                 335     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            340                 345                 350         


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        355                 360                 365             


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    370                 375                 380                 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
385                 390                 395                 400 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                405                 410                 415     


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            420                 425                 430         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        435                 440                 445             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    450                 455                 460                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
465                 470                 475                 480 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                485                 490                 495     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            500                 505                 510         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        515                 520                 525             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    530                 535                 540                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
545                 550                 555                 560 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
                565                 570                 575     


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
            580                 585                 590         


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
        595                 600                 605             


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
    610                 615                 620                 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
625                 630                 635                 640 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
                645                 650                 655     


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
            660                 665                 670         


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
        675                 680                 685             


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Phe Gly Tyr  Ile Pro Glu 
    1205                 1210                 1215             


Ala Pro  Arg Asp Gly Gln Ala  Tyr Val Arg Lys Asp  Gly Glu Trp 
    1220                 1225                 1230             


Val Leu  Leu Ser Thr Phe Leu  Gly Val Asp Gly Gly  Gly Gly Ser 
    1235                 1240                 1245             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1250                 1255                 1260             


Gly Val  Ser Lys Gly Glu Glu  Ala Ser Gly Arg Ala  Leu Phe Gln 
    1265                 1270                 1275             


Tyr Pro  Met Thr Ser Lys Ile  Glu Leu Asn Gly Glu  Ile Asn Gly 
    1280                 1285                 1290             


Lys Lys  Phe Lys Val Ala Gly  Glu Gly Phe Thr Pro  Ser Ser Gly 
    1295                 1300                 1305             


Arg Phe  Asn Met His Ala Tyr  Cys Thr Thr Gly Asp  Leu Pro Met 
    1310                 1315                 1320             


Ser Trp  Val Val Ile Ala Ser  Pro Leu Gln Tyr Gly  Phe His Met 
    1325                 1330                 1335             


Phe Ala  His Tyr Pro Glu Asp  Ile Thr His Phe Phe  Gln Glu Cys 
    1340                 1345                 1350             


Phe Pro  Gly Ser Tyr Thr Leu  Asp Arg Thr Leu Arg  Met Glu Gly 
    1355                 1360                 1365             


Asp Gly  Thr Leu Thr Thr His  His Glu Tyr Ser Leu  Glu Asp Gly 
    1370                 1375                 1380             


Cys Val  Thr Ser Lys Thr Thr  Leu Asn Ala Ser Gly  Phe Asp Pro 
    1385                 1390                 1395             


Lys Gly  Ala Thr Met Thr Lys  Ser Phe Val Lys Gln  Leu Pro Asn 
    1400                 1405                 1410             


Glu Val  Lys Ile Thr Pro His  Gly Pro Asn Gly Ile  Arg Leu Thr 
    1415                 1420                 1425             


Ser Thr  Val Leu Tyr Leu Lys  Glu Asp Gly Thr Ile  Gln Ile Gly 
    1430                 1435                 1440             


Thr Gln  Asp Cys Ile Val Thr  Pro Val Gly Gly Arg  Lys Val Thr 
    1445                 1450                 1455             


Gln Pro  Lys Ala His Phe Leu  His Thr Gln Ile Ile  Gln Lys Lys 
    1460                 1465                 1470             


Asp Pro  Asn Asp Thr Arg Asp  His Ile Val Gln Thr  Glu Leu Ala 
    1475                 1480                 1485             


Val Ala  Gly Asn Leu Trp His  Gly Met Asp Glu Leu  Tyr Lys Ser 
    1490                 1495                 1500             


Leu Glu  His His His His His  His His His 
    1505                 1510             


<210>  27
<211>  1510
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-STN

<400>  27

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
            20                  25                  30          


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        35                  40                  45              


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    50                  55                  60                  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
65                  70                  75                  80  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
                85                  90                  95      


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
        115                 120                 125             


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
    130                 135                 140                 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
145                 150                 155                 160 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
                165                 170                 175     


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
            180                 185                 190         


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
        195                 200                 205             


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
    210                 215                 220                 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
                245                 250                 255     


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
            260                 265                 270         


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
        275                 280                 285             


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
    290                 295                 300                 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
305                 310                 315                 320 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
                325                 330                 335     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            340                 345                 350         


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        355                 360                 365             


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    370                 375                 380                 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
385                 390                 395                 400 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                405                 410                 415     


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            420                 425                 430         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        435                 440                 445             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    450                 455                 460                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
465                 470                 475                 480 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                485                 490                 495     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            500                 505                 510         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        515                 520                 525             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    530                 535                 540                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
545                 550                 555                 560 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
                565                 570                 575     


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
            580                 585                 590         


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
        595                 600                 605             


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
    610                 615                 620                 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
625                 630                 635                 640 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
                645                 650                 655     


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
            660                 665                 670         


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
        675                 680                 685             


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Phe Gly Tyr  Ile Pro Glu 
    1205                 1210                 1215             


Ala Pro  Arg Asp Gly Gln Ala  Tyr Val Arg Lys Asp  Gly Glu Trp 
    1220                 1225                 1230             


Val Leu  Leu Ser Thr Phe Leu  Gly Val Asp Gly Gly  Gly Gly Ser 
    1235                 1240                 1245             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1250                 1255                 1260             


Gly Val  Ser Lys Gly Glu Glu  Asp Asn Met Ala Ser  Leu Pro Ala 
    1265                 1270                 1275             


Thr His  Glu Leu His Ile Phe  Gly Ser Ile Asn Gly  Val Asp Phe 
    1280                 1285                 1290             


Asp Met  Val Gly Gln Gly Thr  Gly Asn Pro Asn Asp  Gly Tyr Glu 
    1295                 1300                 1305             


Glu Leu  Asn Leu Lys Ser Thr  Lys Gly Asp Leu Gln  Phe Ser Pro 
    1310                 1315                 1320             


Trp Ile  Leu Val Pro His Ile  Gly Tyr Gly Phe His  Gln Tyr Leu 
    1325                 1330                 1335             


Pro Tyr  Pro Asp Gly Met Ser  Pro Phe Gln Ala Ala  Met Val Asp 
    1340                 1345                 1350             


Gly Ser  Gly Tyr Gln Val His  Arg Thr Met Gln Phe  Glu Asp Gly 
    1355                 1360                 1365             


Ala Ser  Leu Thr Val Asn Tyr  Arg Tyr Thr Tyr Glu  Gly Ser His 
    1370                 1375                 1380             


Ile Lys  Gly Glu Ala Gln Val  Lys Gly Thr Gly Phe  Pro Ala Asp 
    1385                 1390                 1395             


Gly Pro  Val Met Thr Asn Ser  Leu Thr Ala Ala Asp  Trp Cys Arg 
    1400                 1405                 1410             


Ser Lys  Lys Thr Tyr Pro Asn  Asp Lys Thr Ile Ile  Ser Thr Phe 
    1415                 1420                 1425             


Lys Trp  Ser Tyr Thr Thr Gly  Asn Gly Lys Arg Tyr  Arg Ser Thr 
    1430                 1435                 1440             


Ala Arg  Thr Thr Tyr Thr Phe  Ala Lys Pro Met Ala  Ala Asn Tyr 
    1445                 1450                 1455             


Leu Lys  Asn Gln Pro Met Tyr  Val Phe Arg Lys Thr  Glu Leu Lys 
    1460                 1465                 1470             


His Ser  Lys Thr Glu Leu Asn  Phe Lys Glu Trp Gln  Lys Ala Phe 
    1475                 1480                 1485             


Thr Asp  Val Met Gly Met Asp  Glu Leu Tyr Lys Ser  Leu Glu His 
    1490                 1495                 1500             


His His  His His His His His  
    1505                 1510 


<210>  28
<211>  3765
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-ST

<400>  28
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc      120

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      180

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      240

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      360

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      420

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      480

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      540

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      600

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      660

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      720

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      780

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      840

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      900

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      960

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg     1020

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1080

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1140

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1200

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1260

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1320

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1380

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1440

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1500

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1560

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1620

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1680

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1740

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1800

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1860

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1920

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1980

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     2040

acccagacca acagccccgg tagcgcgagc tctgtggcca gccagagcat catcgcctac     2100

accatgagcc tgggcgccga gaacagcgtg gcctacagca acaacagcat cgccatcccc     2160

accaacttca ccatcagcgt gaccaccgag atcctgcccg tgagcatgac caagaccagc     2220

gtggactgca ccatgtacat ctgcggcgac agcaccgagt gcagcaacct gctgctgcag     2280

tacggcagct tctgcaccca gctgaaccgc gccctgaccg gcatcgccgt ggagcaggac     2340

aagaacaccc aggaggtgtt cgcccaggtg aagcagatat acaagacccc ccccatcaag     2400

gacttcggcg gcttcaactt cagccagatc ctgcccgacc ccagcaagcc cagcaagcgc     2460

agcttcatcg aggacctgct gttcaacaag gtgaccctgg ccgacgccgg cttcatcaag     2520

cagtacggcg actgcctggg cgacatcgcc gcccgcgacc tgatctgcgc ccagaagttc     2580

aacggcctga ccgtgctgcc ccccctgctg accgacgaga tgatcgccca gtacaccagc     2640

gccctgctgg ccggcaccat caccagcggc tggaccttcg gcgccggcgc cgccctgcag     2700

atccccttcg ccatgcagat ggcctaccgc ttcaacggca tcggcgtgac ccagaacgtg     2760

ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg caagatccag     2820

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc aggacgtggt gaaccagaac     2880

gcccaggccc tgaacaccct ggtgaagcag ctgagcagca acttcggcgc catcagcagc     2940

gtgctgaacg acatcctgag ccgcctggac aaggtggagg ccgaggtgca gatcgaccgc     3000

ctgatcaccg gccgcctgca gagcctgcag acctacgtga cccagcagct gatccgcgcc     3060

gccgagatcc gcgccagcgc caacctggcc gccaccaaga tgagcgagtg cgtgctgggc     3120

cagagcaagc gcgtggactt ctgcggcaag ggctaccacc tgatgagctt cccccagagc     3180

gccccccacg gcgtggtgtt cctgcacgtg acctacgtgc ccgcccagga gaagaacttc     3240

accaccgccc ccgccatctg ccacgacggc aaggcccact tcccccgcga gggcgtgttc     3300

gtgagcaacg gcacccactg gttcgtgacc cagcgcaact tctacgagcc ccagatcatc     3360

accaccgaca acaccttcgt gagcggcaac tgcgacgtgg tgatcggcat cgtgaacaac     3420

accgtgtacg accccctgca gcccgagctg gacagcttca aggaggagct ggacaagtac     3480

ttcaagaacc acaccagccc cgacgtggac ctgggcgaca tcagcggcat caacgctagc     3540

gtggtgaaca tccagaagga gatcgaccgc ctgaacgagg tggccaagaa cctgaacgag     3600

agcctgatcg acctgcagga gctgggcaag tacgagcagg gatccggtta catccccgag     3660

gccccccgcg acggccaggc ctacgtgcgc aaggacggcg agtgggtgct gctgagcacc     3720

ttcctgggca gcctcgagca tcaccaccac caccaccacc actaa                     3765


<210>  29
<211>  1254
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-ST

<400>  29

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
            20                  25                  30          


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        35                  40                  45              


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    50                  55                  60                  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
65                  70                  75                  80  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
                85                  90                  95      


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
        115                 120                 125             


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
    130                 135                 140                 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
145                 150                 155                 160 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
                165                 170                 175     


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
            180                 185                 190         


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
        195                 200                 205             


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
    210                 215                 220                 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
                245                 250                 255     


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
            260                 265                 270         


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
        275                 280                 285             


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
    290                 295                 300                 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
305                 310                 315                 320 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
                325                 330                 335     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            340                 345                 350         


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        355                 360                 365             


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    370                 375                 380                 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
385                 390                 395                 400 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                405                 410                 415     


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            420                 425                 430         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        435                 440                 445             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    450                 455                 460                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
465                 470                 475                 480 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                485                 490                 495     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            500                 505                 510         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        515                 520                 525             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    530                 535                 540                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
545                 550                 555                 560 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
                565                 570                 575     


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
            580                 585                 590         


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
        595                 600                 605             


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
    610                 615                 620                 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
625                 630                 635                 640 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
                645                 650                 655     


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
            660                 665                 670         


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
        675                 680                 685             


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln Gly Ser  Gly Tyr Ile 
    1205                 1210                 1215             


Pro Glu  Ala Pro Arg Asp Gly  Gln Ala Tyr Val Arg  Lys Asp Gly 
    1220                 1225                 1230             


Glu Trp  Val Leu Leu Ser Thr  Phe Leu Gly Ser Leu  Glu His His 
    1235                 1240                 1245             


His His  His His His His 
    1250                 


<210>  30
<211>  2415
<212>  DNA
<213>  ˹

<220>
<223>  hACE2

<400>  30
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct ccttt                                                      2415


<210>  31
<211>  3183
<212>  DNA
<213>  ˹

<220>
<223>  hACE2mRb3

<400>  31
atgtcaagct cttcctggct ccttctcagc cttgttgctg taactgctgc tcagtccacc       60

attgaggaac aggccaagac atttttggac aagtttaacc acgaagccga agacctgttc      120

tatcaaagtt cacttgcttc ttggaattat aacaccaata ttactgaaga gaatgtccaa      180

aacatgaata atgctgggga caaatggtct gcctttttaa aggaacagtc cacacttgcc      240

caaatgtatc cactacaaga aattcagaat ctcacagtca agcttcagct gcaggctctt      300

cagcaaaatg ggtcttcagt gctctcagaa gacaagagca aacggttgaa cacaattcta      360

aatacaatga gcaccatcta cagtactgga aaagtttgta acccagataa tccacaagaa      420

tgcttattac ttgaaccagg tttgaatgaa ataatggcaa acagtttaga ctacaatgag      480

aggctctggg cttgggaaag ctggagatct gaggtcggca agcagctgag gccattatat      540

gaagagtatg tggtcttgaa aaatgagatg gcaagagcaa atcattatga ggactatggg      600

gattattgga gaggagacta tgaagtaaat ggggtagatg gctatgacta cagccgcggc      660

cagttgattg aagatgtgga acataccttt gaagagatta aaccattata tgaacatctt      720

catgcctatg tgagggcaaa gttgatgaat gcctatcctt cctatatcag tccaattgga      780

tgcctccctg ctcatttgct tggtgatatg tggggtagat tttggacaaa tctgtactct      840

ttgacagttc cctttggaca gaaaccaaac atagatgtta ctgatgcaat ggtggaccag      900

gcctgggatg cacagagaat attcaaggag gccgagaagt tctttgtatc tgttggtctt      960

cctaatatga ctcaaggatt ctgggaaaat tccatgctaa cggacccagg aaatgttcag     1020

aaagcagtct gccatcccac agcttgggac ctggggaagg gcgacttcag gatccttatg     1080

tgcacaaagg tgacaatgga cgacttcctg acagctcatc atgagatggg gcatatccag     1140

tatgatatgg catatgctgc acaacctttt ctgctaagaa atggagctaa tgaaggattc     1200

catgaagctg ttggggaaat catgtcactt tctgcagcca cacctaagca tttaaaatcc     1260

attggtcttc tgtcacccga ttttcaagaa gacaatgaaa cagaaataaa cttcctgctc     1320

aaacaagcac tcacgattgt tgggactctg ccatttactt acatgttaga gaagtggagg     1380

tggatggtct ttaaagggga aattcccaaa gaccagtgga tgaaaaagtg gtgggagatg     1440

aagcgagaga tagttggggt ggtggaacct gtgccccatg atgaaacata ctgtgacccc     1500

gcatctctgt tccatgtttc taatgattac tcattcattc gatattacac aaggaccctt     1560

taccaattcc agtttcaaga agcactttgt caagcagcta aacatgaagg ccctctgcac     1620

aaatgtgaca tctcaaactc tacagaagct ggacagaaac tgttcaatat gctgaggctt     1680

ggaaaatcag aaccctggac cctagcattg gaaaatgttg taggagcaaa gaacatgaat     1740

gtaaggccac tgctcaacta ctttgagccc ttatttacct ggctgaaaga ccagaacaag     1800

aattcttttg tgggatggag taccgactgg agtccatatg cagaccaaag catcaaagtg     1860

aggataagcc taaaatcagc tcttggagat aaagcatatg aatggaacga caatgaaatg     1920

tacctgttcc gatcatctgt tgcatatgct atgaggcagt actttttaaa agtaaaaaat     1980

cagatgattc tttttgggga ggaggatgtg cgagtggcta atttgaaacc aagaatctcc     2040

tttaatttct ttgtcactgc acctaaaaat gtgtctgata tcattcctag aactgaagtt     2100

gaaaaggcca tcaggatgtc ccggagccgt atcaatgatg ctttccgtct gaatgacaac     2160

agcctagagt ttctggggat acagccaaca cttggacctc ctaaccagcc ccctgtttcc     2220

atatggctga ttgtttttgg agttgtgatg ggagtgatag tggttggcat tgtcatcctg     2280

atcttcactg ggatcagaga tcggaagaag aaaaataaag caagaagtgg agaaaatcct     2340

tatgcctcca tcgatattag caaaggagaa aataatccag gattccaaaa cactgatgat     2400

gttcagacct cctttgctag cggcggtggt ggcagcggta gcggttctgt gagcaagggc     2460

gaggagctga tcaaggagaa catgcgcatg aaggtggtga tggagggcag cgtgaacggc     2520

caccagttca agtgcaccgg cgagggcgag ggccgcccct acgagggcgt gcagaccatg     2580

cgcatcaagg tgatcgaggg cggccccctg cccttcgcct tcgacatcct ggccaccagc     2640

ttcatgtacg gcagccgcac cttcatcaag taccccgccg acatccccga cttcttcaag     2700

cagagcttcc ccgagggctt cacctgggag cgcgtgaccc gctacgagga cggcggcgtg     2760

gtgaccgtga cccaggacac cagcctggag gacggcgagc tggtgtacaa cgtgaaggtg     2820

cgcggcgtga acttccccag caacggcccc gtgatgcaga agaagaccaa gggctgggag     2880

cccaacaccg agatgatgta ccccgccgac ggcggcctgc gcggctacac cgacatcgcc     2940

ctgaaggtgg acggcggcgg ccacctgcac tgcaacttcg tgaccaccta ccgcagcaag     3000

aagaccgtgg gcaacatcaa gatgcccggc gtgcacgccg tggaccaccg cctggagcgc     3060

atcgaggaga gcgacaacga gacctacgtg gtgcagcgcg aggtggccgt ggccaagtac     3120

agcaacctgg gcggcggcat ggacgagctg tacaagggat cccaccacca ccaccaccac     3180

taa                                                                   3183


<210>  32
<211>  1060
<212>  PRT
<213>  ˹

<220>
<223>  hACE2mRb3

<400>  32

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe Ala Ser Gly Gly Gly Gly Ser Gly Ser Gly Ser 
                805                 810                 815     


Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met Arg Met Lys Val 
            820                 825                 830         


Val Met Glu Gly Ser Val Asn Gly His Gln Phe Lys Cys Thr Gly Glu 
        835                 840                 845             


Gly Glu Gly Arg Pro Tyr Glu Gly Val Gln Thr Met Arg Ile Lys Val 
    850                 855                 860                 


Ile Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser 
865                 870                 875                 880 


Phe Met Tyr Gly Ser Arg Thr Phe Ile Lys Tyr Pro Ala Asp Ile Pro 
                885                 890                 895     


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
            900                 905                 910         


Thr Arg Tyr Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Thr Ser 
        915                 920                 925             


Leu Glu Asp Gly Glu Leu Val Tyr Asn Val Lys Val Arg Gly Val Asn 
    930                 935                 940                 


Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Lys Gly Trp Glu 
945                 950                 955                 960 


Pro Asn Thr Glu Met Met Tyr Pro Ala Asp Gly Gly Leu Arg Gly Tyr 
                965                 970                 975     


Thr Asp Ile Ala Leu Lys Val Asp Gly Gly Gly His Leu His Cys Asn 
            980                 985                 990         


Phe Val Thr Thr Tyr Arg Ser Lys  Lys Thr Val Gly Asn  Ile Lys Met 
        995                 1000                 1005             


Pro Gly  Val His Ala Val Asp  His Arg Leu Glu Arg  Ile Glu Glu 
    1010                 1015                 1020             


Ser Asp  Asn Glu Thr Tyr Val  Val Gln Arg Glu Val  Ala Val Ala 
    1025                 1030                 1035             


Lys Tyr  Ser Asn Leu Gly Gly  Gly Met Asp Glu Leu  Tyr Lys Gly 
    1040                 1045                 1050             


Ser His  His His His His His  
    1055                 1060 


<210>  33
<211>  1483
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-SMG

<400>  33

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
            20                  25                  30          


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        35                  40                  45              


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    50                  55                  60                  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
65                  70                  75                  80  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
                85                  90                  95      


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
        115                 120                 125             


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
    130                 135                 140                 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
145                 150                 155                 160 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
                165                 170                 175     


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
            180                 185                 190         


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
        195                 200                 205             


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
    210                 215                 220                 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
                245                 250                 255     


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
            260                 265                 270         


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
        275                 280                 285             


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
    290                 295                 300                 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
305                 310                 315                 320 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
                325                 330                 335     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            340                 345                 350         


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        355                 360                 365             


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    370                 375                 380                 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
385                 390                 395                 400 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                405                 410                 415     


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            420                 425                 430         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        435                 440                 445             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    450                 455                 460                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
465                 470                 475                 480 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                485                 490                 495     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            500                 505                 510         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        515                 520                 525             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    530                 535                 540                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
545                 550                 555                 560 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
                565                 570                 575     


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
            580                 585                 590         


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
        595                 600                 605             


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
    610                 615                 620                 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
625                 630                 635                 640 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
                645                 650                 655     


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
            660                 665                 670         


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Gly Ser 
        675                 680                 685             


Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
    690                 695                 700                 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
705                 710                 715                 720 


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
                725                 730                 735     


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
            740                 745                 750         


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
        755                 760                 765             


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
    770                 775                 780                 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
785                 790                 795                 800 


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
                805                 810                 815     


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
            820                 825                 830         


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
        835                 840                 845             


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
    850                 855                 860                 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
865                 870                 875                 880 


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
                885                 890                 895     


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
            900                 905                 910         


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
        915                 920                 925             


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
    930                 935                 940                 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
945                 950                 955                 960 


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
                965                 970                 975     


Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val 
            980                 985                 990         


Glu Ala Glu Val Gln Ile Asp Arg  Leu Ile Thr Gly Arg  Leu Gln Ser 
        995                 1000                 1005             


Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile 
    1010                 1015                 1020             


Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val 
    1025                 1030                 1035             


Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His 
    1040                 1045                 1050             


Leu Met  Ser Phe Pro Gln Ser  Ala Pro His Gly Val  Val Phe Leu 
    1055                 1060                 1065             


His Val  Thr Tyr Val Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala 
    1070                 1075                 1080             


Pro Ala  Ile Cys His Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly 
    1085                 1090                 1095             


Val Phe  Val Ser Asn Gly Thr  His Trp Phe Val Thr  Gln Arg Asn 
    1100                 1105                 1110             


Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser 
    1115                 1120                 1125             


Gly Asn  Cys Asp Val Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr 
    1130                 1135                 1140             


Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp 
    1145                 1150                 1155             


Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp Val Asp  Leu Gly Asp 
    1160                 1165                 1170             


Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile 
    1175                 1180                 1185             


Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile 
    1190                 1195                 1200             


Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Phe Gly Gly  Gly Gly Ser 
    1205                 1210                 1215             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1220                 1225                 1230             


Gly Val  Ser Lys Gly Glu Glu  Ala Ser Gly Arg Ala  Leu Phe Gln 
    1235                 1240                 1245             


Tyr Pro  Met Thr Ser Lys Ile  Glu Leu Asn Gly Glu  Ile Asn Gly 
    1250                 1255                 1260             


Lys Lys  Phe Lys Val Ala Gly  Glu Gly Phe Thr Pro  Ser Ser Gly 
    1265                 1270                 1275             


Arg Phe  Asn Met His Ala Tyr  Cys Thr Thr Gly Asp  Leu Pro Met 
    1280                 1285                 1290             


Ser Trp  Val Val Ile Ala Ser  Pro Leu Gln Tyr Gly  Phe His Met 
    1295                 1300                 1305             


Phe Ala  His Tyr Pro Glu Asp  Ile Thr His Phe Phe  Gln Glu Cys 
    1310                 1315                 1320             


Phe Pro  Gly Ser Tyr Thr Leu  Asp Arg Thr Leu Arg  Met Glu Gly 
    1325                 1330                 1335             


Asp Gly  Thr Leu Thr Thr His  His Glu Tyr Ser Leu  Glu Asp Gly 
    1340                 1345                 1350             


Cys Val  Thr Ser Lys Thr Thr  Leu Asn Ala Ser Gly  Phe Asp Pro 
    1355                 1360                 1365             


Lys Gly  Ala Thr Met Thr Lys  Ser Phe Val Lys Gln  Leu Pro Asn 
    1370                 1375                 1380             


Glu Val  Lys Ile Thr Pro His  Gly Pro Asn Gly Ile  Arg Leu Thr 
    1385                 1390                 1395             


Ser Thr  Val Leu Tyr Leu Lys  Glu Asp Gly Thr Ile  Gln Ile Gly 
    1400                 1405                 1410             


Thr Gln  Asp Cys Ile Val Thr  Pro Val Gly Gly Arg  Lys Val Thr 
    1415                 1420                 1425             


Gln Pro  Lys Ala His Phe Leu  His Thr Gln Ile Ile  Gln Lys Lys 
    1430                 1435                 1440             


Asp Pro  Asn Asp Thr Arg Asp  His Ile Val Gln Thr  Glu Leu Ala 
    1445                 1450                 1455             


Val Ala  Gly Asn Leu Trp His  Gly Met Asp Glu Leu  Tyr Lys Ser 
    1460                 1465                 1470             


Leu Glu  His His His His His  His His His 
    1475                 1480             


<210>  34
<211>  4452
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-SMG

<400>  34
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc      120

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      180

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      240

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      360

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      420

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      480

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      540

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      600

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      660

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      720

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      780

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      840

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      900

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      960

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg     1020

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1080

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1140

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1200

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1260

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1320

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1380

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1440

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1500

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1560

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1620

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1680

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1740

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1800

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1860

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1920

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1980

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     2040

acccagacca acagccccgg tagcgcgagc tctgtggcca gccagagcat catcgcctac     2100

accatgagcc tgggcgccga gaacagcgtg gcctacagca acaacagcat cgccatcccc     2160

accaacttca ccatcagcgt gaccaccgag atcctgcccg tgagcatgac caagaccagc     2220

gtggactgca ccatgtacat ctgcggcgac agcaccgagt gcagcaacct gctgctgcag     2280

tacggcagct tctgcaccca gctgaaccgc gccctgaccg gcatcgccgt ggagcaggac     2340

aagaacaccc aggaggtgtt cgcccaggtg aagcagatat acaagacccc ccccatcaag     2400

gacttcggcg gcttcaactt cagccagatc ctgcccgacc ccagcaagcc cagcaagcgc     2460

agcttcatcg aggacctgct gttcaacaag gtgaccctgg ccgacgccgg cttcatcaag     2520

cagtacggcg actgcctggg cgacatcgcc gcccgcgacc tgatctgcgc ccagaagttc     2580

aacggcctga ccgtgctgcc ccccctgctg accgacgaga tgatcgccca gtacaccagc     2640

gccctgctgg ccggcaccat caccagcggc tggaccttcg gcgccggcgc cgccctgcag     2700

atccccttcg ccatgcagat ggcctaccgc ttcaacggca tcggcgtgac ccagaacgtg     2760

ctgtacgaga accagaagct gatcgccaac cagttcaaca gcgccatcgg caagatccag     2820

gacagcctga gcagcaccgc cagcgccctg ggcaagctgc aggacgtggt gaaccagaac     2880

gcccaggccc tgaacaccct ggtgaagcag ctgagcagca acttcggcgc catcagcagc     2940

gtgctgaacg acatcctgag ccgcctggac aaggtggagg ccgaggtgca gatcgaccgc     3000

ctgatcaccg gccgcctgca gagcctgcag acctacgtga cccagcagct gatccgcgcc     3060

gccgagatcc gcgccagcgc caacctggcc gccaccaaga tgagcgagtg cgtgctgggc     3120

cagagcaagc gcgtggactt ctgcggcaag ggctaccacc tgatgagctt cccccagagc     3180

gccccccacg gcgtggtgtt cctgcacgtg acctacgtgc ccgcccagga gaagaacttc     3240

accaccgccc ccgccatctg ccacgacggc aaggcccact tcccccgcga gggcgtgttc     3300

gtgagcaacg gcacccactg gttcgtgacc cagcgcaact tctacgagcc ccagatcatc     3360

accaccgaca acaccttcgt gagcggcaac tgcgacgtgg tgatcggcat cgtgaacaac     3420

accgtgtacg accccctgca gcccgagctg gacagcttca aggaggagct ggacaagtac     3480

ttcaagaacc acaccagccc cgacgtggac ctgggcgaca tcagcggcat caacgctagc     3540

gtggtgaaca tccagaagga gatcgaccgc ctgaacgagg tggccaagaa cctgaacgag     3600

agcctgatcg acctgcagga gctgggcaag tacgaattcg gcggcggagg aagcggagga     3660

ggtggcagcg gtggcggtgg ctccggcgga ggtggatccg gcgtgagcaa gggcgaggag     3720

gcatctggca gagccctgtt ccagtacccc atgaccagca agatcgagct gaacggcgag     3780

atcaacggca agaaattcaa ggtggccggc gagggcttca cccccagcag cggcagattc     3840

aacatgcacg cctactgcac caccggcgac ctgcctatga gctgggtcgt gattgccagc     3900

cccctccagt acggcttcca catgttcgcc cactaccccg aggacatcac acactttttc     3960

caggaatgct tccccggcag ctacaccctg gaccggaccc tgagaatgga aggcgacggc     4020

accctgacca cccaccacga gtacagcctg gaggacggct gcgtgacctc caagaccacc     4080

ctgaatgcca gcggcttcga ccctaagggc gccaccatga ccaagagctt cgtgaaacaa     4140

ctgcctaacg aggtgaagat caccccccac ggccccaacg gcatcagact gaccagcacc     4200

gtgctgtacc tgaaggagga tggcaccatc cagatcggca cccaggactg catcgtgacc     4260

cctgtgggcg gaaggaaagt gacccagccc aaggcccact tcctgcacac ccagatcatc     4320

cagaagaagg accccaacga cacccgggac cacatcgtgc agacagaact ggccgtggcc     4380

ggcaatctgt ggcacggcat ggacgagctg tacaagagcc tcgagcatca ccaccaccac     4440

caccaccact aa                                                         4452


<210>  35
<211>  699
<212>  PRT
<213>  ˹

<220>
<223>  SARS-CoV2-S1

<400>  35

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
            20                  25                  30          


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
        35                  40                  45              


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
    50                  55                  60                  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
65                  70                  75                  80  


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
                85                  90                  95      


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
            100                 105                 110         


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
        115                 120                 125             


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
    130                 135                 140                 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
145                 150                 155                 160 


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
                165                 170                 175     


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
            180                 185                 190         


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
        195                 200                 205             


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
    210                 215                 220                 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
225                 230                 235                 240 


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
                245                 250                 255     


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
            260                 265                 270         


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
        275                 280                 285             


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
    290                 295                 300                 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
305                 310                 315                 320 


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
                325                 330                 335     


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
            340                 345                 350         


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
        355                 360                 365             


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
    370                 375                 380                 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
385                 390                 395                 400 


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
                405                 410                 415     


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
            420                 425                 430         


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
        435                 440                 445             


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
    450                 455                 460                 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
465                 470                 475                 480 


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
                485                 490                 495     


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
            500                 505                 510         


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
        515                 520                 525             


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
    530                 535                 540                 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
545                 550                 555                 560 


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
                565                 570                 575     


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
            580                 585                 590         


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
        595                 600                 605             


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
    610                 615                 620                 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
625                 630                 635                 640 


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
                645                 650                 655     


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
            660                 665                 670         


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg 
        675                 680                 685             


Gly Gly Gly Gly Ser His His His His His His 
    690                 695                 


<210>  36
<211>  2100
<212>  DNA
<213>  ˹

<220>
<223>  SARS-CoV2-S1

<400>  36
atggcccgca gcgtgaccct ggtgttcctg gtgctggtga gcctgaccgg tctgtacgcc       60

gtgaacctga ccacccgcac ccagctgccc cccgcctaca ccaacagctt cacccgcggc      120

gtgtactacc ccgacaaggt gttccgcagc agcgtgctgc acagcaccca ggacctgttc      180

ctgcccttct tcagcaacgt gacctggttc cacgccatcc acgtgagcgg caccaacggc      240

accaagcgct tcgacaaccc cgtgctgccc ttcaacgacg gcgtgtactt cgccagcacc      300

gagaagagca acatcatccg cggctggatc ttcggcacca ccctggacag caagacccag      360

agcctgctga tcgtgaacaa cgccaccaac gtggtgatca aggtgtgcga gttccagttc      420

tgcaacgacc ccttcctggg cgtgtactac cacaagaaca acaagagctg gatggagagc      480

gagttccgcg tgtacagcag cgccaacaac tgcaccttcg agtacgtgag ccagcccttc      540

ctgatggacc tggagggcaa gcagggcaac ttcaagaacc tgcgcgagtt cgtgttcaag      600

aacatcgacg gctacttcaa gatatacagc aagcacaccc ccatcaacct ggtgcgcgac      660

ctgccccagg gcttcagcgc cctggagccc ctggtggacc tgcccatcgg catcaacatc      720

acccgcttcc agaccctgct ggccctgcac cgcagctacc tgacccccgg cgacagcagc      780

agcggctgga ccgccggcgc cgccgcctac tacgtgggct acctgcagcc ccgcaccttc      840

ctgctgaagt acaacgagaa cggcaccatc accgacgccg tggactgcgc cctggacccc      900

ctgagcgaga ccaagtgcac cctgaagagc ttcaccgtgg agaagggcat ctaccagacc      960

agcaacttcc gcgtgcagcc caccgagagc atcgtgcgct tccccaacat caccaacctg     1020

tgccccttcg gcgaggtgtt caacgccacc cgcttcgcca gcgtgtacgc ctggaaccgc     1080

aagcgcatca gcaactgcgt ggccgactac agcgtgctgt acaacagcgc cagcttcagc     1140

accttcaagt gctacggcgt gagccccacc aagctgaacg acctgtgctt caccaacgtg     1200

tacgccgaca gcttcgtgat ccgcggcgac gaggtgcgcc agatcgcccc cggccagacc     1260

ggcaagatcg ccgactacaa ctacaagctg cccgacgact tcaccggctg cgtgatcgcc     1320

tggaacagca acaacctgga cagcaaggtg ggcggcaact acaactacct gtaccgcctg     1380

ttccgcaaga gcaacctgaa gcccttcgag cgcgacatca gcaccgagat ataccaggcc     1440

ggcagcaccc cctgcaacgg cgtggagggc ttcaactgct acttccccct gcagagctac     1500

ggcttccagc ccaccaacgg cgtgggctac cagccctacc gcgtggtggt gctgagcttc     1560

gagctgctgc acgcccccgc caccgtgtgc ggccccaaga agagcaccaa cctggtgaag     1620

aacaagtgcg tgaacttcaa cttcaacggc ctgaccggca ccggcgtgct gaccgagagc     1680

aacaagaagt tcctgccctt ccagcagttc ggccgcgaca tcgccgacac caccgacgcc     1740

gtgcgcgacc cccagaccct ggagatcctg gacatcaccc cctgcagctt cggcggcgtg     1800

agcgtgatca cccccggcac caacaccagc aaccaggtgg ccgtgctgta ccaggacgtg     1860

aactgcaccg aggtgcccgt ggccatccac gccgaccagc tgacccccac ctggcgcgtg     1920

tacagcaccg gcagcaacgt gttccagacc cgcgccggct gcctgatcgg cgccgagcac     1980

gtgaacaaca gctacgagtg cgacatcccc atcggcgccg gcatctgcgc cagctaccag     2040

acccagacca acagcccccg ccgcggtggc ggtggatccc accaccacca ccaccactaa     2100


<210>  37
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  B2Mźģ

<400>  37

Met Ala Arg Ser Val Thr Leu Val Phe Leu Val Leu Val Ser Leu Thr 
1               5                   10                  15      


Gly Leu Tyr Ala 
            20  


<210>  38
<211>  238
<212>  PRT
<213>  ˹

<220>
<223>  ɫӫ⵰mGamillus

<400>  38

Val Ser Lys Gly Glu Glu Ala Ser Gly Arg Ala Leu Phe Gln Tyr Pro 
1               5                   10                  15      


Met Thr Ser Lys Ile Glu Leu Asn Gly Glu Ile Asn Gly Lys Lys Phe 
            20                  25                  30          


Lys Val Ala Gly Glu Gly Phe Thr Pro Ser Ser Gly Arg Phe Asn Met 
        35                  40                  45              


His Ala Tyr Cys Thr Thr Gly Asp Leu Pro Met Ser Trp Val Val Ile 
    50                  55                  60                  


Ala Ser Pro Leu Gln Tyr Gly Phe His Met Phe Ala His Tyr Pro Glu 
65                  70                  75                  80  


Asp Ile Thr His Phe Phe Gln Glu Cys Phe Pro Gly Ser Tyr Thr Leu 
                85                  90                  95      


Asp Arg Thr Leu Arg Met Glu Gly Asp Gly Thr Leu Thr Thr His His 
            100                 105                 110         


Glu Tyr Ser Leu Glu Asp Gly Cys Val Thr Ser Lys Thr Thr Leu Asn 
        115                 120                 125             


Ala Ser Gly Phe Asp Pro Lys Gly Ala Thr Met Thr Lys Ser Phe Val 
    130                 135                 140                 


Lys Gln Leu Pro Asn Glu Val Lys Ile Thr Pro His Gly Pro Asn Gly 
145                 150                 155                 160 


Ile Arg Leu Thr Ser Thr Val Leu Tyr Leu Lys Glu Asp Gly Thr Ile 
                165                 170                 175     


Gln Ile Gly Thr Gln Asp Cys Ile Val Thr Pro Val Gly Gly Arg Lys 
            180                 185                 190         


Val Thr Gln Pro Lys Ala His Phe Leu His Thr Gln Ile Ile Gln Lys 
        195                 200                 205             


Lys Asp Pro Asn Asp Thr Arg Asp His Ile Val Gln Thr Glu Leu Ala 
    210                 215                 220                 


Val Ala Gly Asn Leu Trp His Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235             


<210>  39
<211>  235
<212>  PRT
<213>  ˹

<220>
<223>  ɫӫ⵰mNeonGreen

<400>  39

Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ser Leu Pro Ala Thr His 
1               5                   10                  15      


Glu Leu His Ile Phe Gly Ser Ile Asn Gly Val Asp Phe Asp Met Val 
            20                  25                  30          


Gly Gln Gly Thr Gly Asn Pro Asn Asp Gly Tyr Glu Glu Leu Asn Leu 
        35                  40                  45              


Lys Ser Thr Lys Gly Asp Leu Gln Phe Ser Pro Trp Ile Leu Val Pro 
    50                  55                  60                  


His Ile Gly Tyr Gly Phe His Gln Tyr Leu Pro Tyr Pro Asp Gly Met 
65                  70                  75                  80  


Ser Pro Phe Gln Ala Ala Met Val Asp Gly Ser Gly Tyr Gln Val His 
                85                  90                  95      


Arg Thr Met Gln Phe Glu Asp Gly Ala Ser Leu Thr Val Asn Tyr Arg 
            100                 105                 110         


Tyr Thr Tyr Glu Gly Ser His Ile Lys Gly Glu Ala Gln Val Lys Gly 
        115                 120                 125             


Thr Gly Phe Pro Ala Asp Gly Pro Val Met Thr Asn Ser Leu Thr Ala 
    130                 135                 140                 


Ala Asp Trp Cys Arg Ser Lys Lys Thr Tyr Pro Asn Asp Lys Thr Ile 
145                 150                 155                 160 


Ile Ser Thr Phe Lys Trp Ser Tyr Thr Thr Gly Asn Gly Lys Arg Tyr 
                165                 170                 175     


Arg Ser Thr Ala Arg Thr Thr Tyr Thr Phe Ala Lys Pro Met Ala Ala 
            180                 185                 190         


Asn Tyr Leu Lys Asn Gln Pro Met Tyr Val Phe Arg Lys Thr Glu Leu 
        195                 200                 205             


Lys His Ser Lys Thr Glu Leu Asn Phe Lys Glu Trp Gln Lys Ala Phe 
    210                 215                 220                 


Thr Asp Val Met Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235 


<210>  40
<211>  27
<212>  PRT
<213>  ˹

<220>
<223>  TFD

<400>  40

Tyr Ile Pro Glu Ala Pro Arg Asp Gly Gln Ala Tyr Val Arg Lys Asp 
1               5                   10                  15      


Gly Glu Trp Val Leu Leu Ser Thr Phe Leu Gly 
            20                  25          


<210>  41
<211>  805
<212>  PRT
<213>  ˹

<220>
<223>  hACE2

<400>  41

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  42
<211>  236
<212>  PRT
<213>  ˹

<220>
<223>  ɫӫ⵰mRuby3

<400>  42

Val Ser Lys Gly Glu Glu Leu Ile Lys Glu Asn Met Arg Met Lys Val 
1               5                   10                  15      


Val Met Glu Gly Ser Val Asn Gly His Gln Phe Lys Cys Thr Gly Glu 
            20                  25                  30          


Gly Glu Gly Arg Pro Tyr Glu Gly Val Gln Thr Met Arg Ile Lys Val 
        35                  40                  45              


Ile Glu Gly Gly Pro Leu Pro Phe Ala Phe Asp Ile Leu Ala Thr Ser 
    50                  55                  60                  


Phe Met Tyr Gly Ser Arg Thr Phe Ile Lys Tyr Pro Ala Asp Ile Pro 
65                  70                  75                  80  


Asp Phe Phe Lys Gln Ser Phe Pro Glu Gly Phe Thr Trp Glu Arg Val 
                85                  90                  95      


Thr Arg Tyr Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Thr Ser 
            100                 105                 110         


Leu Glu Asp Gly Glu Leu Val Tyr Asn Val Lys Val Arg Gly Val Asn 
        115                 120                 125             


Phe Pro Ser Asn Gly Pro Val Met Gln Lys Lys Thr Lys Gly Trp Glu 
    130                 135                 140                 


Pro Asn Thr Glu Met Met Tyr Pro Ala Asp Gly Gly Leu Arg Gly Tyr 
145                 150                 155                 160 


Thr Asp Ile Ala Leu Lys Val Asp Gly Gly Gly His Leu His Cys Asn 
                165                 170                 175     


Phe Val Thr Thr Tyr Arg Ser Lys Lys Thr Val Gly Asn Ile Lys Met 
            180                 185                 190         


Pro Gly Val His Ala Val Asp His Arg Leu Glu Arg Ile Glu Glu Ser 
        195                 200                 205             


Asp Asn Glu Thr Tyr Val Val Gln Arg Glu Val Ala Val Ala Lys Tyr 
    210                 215                 220                 


Ser Asn Leu Gly Gly Gly Met Asp Glu Leu Tyr Lys 
225                 230                 235     


