                         б

<110>  ϺƼ޹˾
 
<120>  ˲嵰C5Ŀ弰Ӧ

<130>  LC21210005P

<150>  CN202010347154.3
<151>  2020-04-28

<160>  101   

<170>  PatentIn version 3.3

<210>  1
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  1

Glu Val Leu Leu Leu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Leu Lys Ile Pro Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


His Leu Asp Trp Val Lys Gln Ser His Gly Lys Arg Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asp Pro Asp Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Thr Ala Ala Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  2
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  2

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  3

Gln Val His Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Leu Ser Cys Lys Ala Ser Asp Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Asp Ile Asn Trp Val Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Phe Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Asn Ser Tyr Val Phe Asp His Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  4
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  4

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  5
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Gln Pro Gly Thr 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Arg Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Asp Leu Asn Trp Met Arg Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Thr Asp Thr Ala Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Val Gly Asp Tyr Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Ala Thr Leu Thr Val Ser Ser 
        115                 


<210>  6
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  6

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Thr Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Gln Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Val Met Lys 
            100                 105         


<210>  7
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Met Ile His Pro Ser Asp Ser Glu Ile Met Leu Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Asn Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Tyr Ser Pro Thr Ser Glu Asp Ser Ala Ile Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Ser Ser Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  8
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  8

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Phe Gln Leu Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Asn 
            100                 105         


<210>  9
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  9

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ala Val Lys Ile Ser Cys Arg Thr Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Tyr Leu His Trp Met Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Leu Ser Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Ser Leu Thr Ala Asp Arg Ser Ser Ser Ile Ala Ser 
65                  70                  75                  80  


Ile Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Lys Ser His Tyr Asn Asp Tyr Leu Thr Gly Ala Met Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  10

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Ala Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Phe Gly Ile Pro Ser Arg Phe Arg Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Ile Tyr Tyr Cys Gln Gln His Asp Gln Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  117
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Arg Asp Ile 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Tyr 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ser Gly His Thr Glu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Ala Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Gly Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Glu Gly Ile Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Gly Val Ser Ala 
        115         


<210>  12
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  12

Asp Ile Val Met Thr Gln Ser Gln Lys Phe Arg Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Arg Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  13
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  13

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Arg Asn Lys Thr Asn Asn His Ala Thr Tyr Tyr Thr Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gln Gly Asp Gly Tyr Tyr Val Arg Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  14
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  14

Asp Ile Gln Met Ile Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Thr Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Gln Phe Ser Leu Asn Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Ile 
            100                 105         


<210>  15
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  15

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly 
1               5                   10                  15      


Thr Met Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Arg Asn Lys Thr Asn Asn His Ala Thr Tyr Tyr Thr Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Thr Arg Gln Gly Asp Gly Tyr Tyr Val Arg Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         


<210>  16
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  16

Asp Ile Gln Met Ile Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Thr Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro His Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Gly Gly Ser Gly Thr Gln Phe Ser Leu Asn Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  17
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  17

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Leu His Trp Leu Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Arg Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ser Arg Ser Asp Tyr Asp Tyr Asp Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  106
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  18

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Ser 
        35                  40                  45              


Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Tyr His Ser Tyr Pro Phe Thr 
                85                  90                  95      


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105     


<210>  19
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Asp Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Met Gly Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Ile Asn Ser Leu Thr Asp Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Asp Gly Val Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  20
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  20

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  21
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Ser Gly Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Ser Gly Gly Gly Thr Asn Tyr Tyr Pro Asp Ile Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Asp Tyr Gly Tyr Trp Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ala 
        115                 


<210>  22
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  22

Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  23
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  23

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


His Leu Asp Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Asp Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  24
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  24

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
            20                  25                  30          


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  25
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


His Leu Asp Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Asp Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Val Asp Lys Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  26
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  26

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


His Leu Asp Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Asp Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  27
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  27

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


His Leu Asp Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Tyr Ile Asp Pro Asp Thr Gly Gly Thr Phe Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  28
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  28

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Tyr Leu His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Leu Ser Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Ser His Tyr Asn Asp Tyr Leu Thr Gly Ala Met Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  29
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Phe Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asp Gln Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  30

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Tyr Leu His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Leu Ser Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser His Tyr Asn Asp Tyr Leu Thr Gly Ala Met Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  31
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  31

Asp Val Gln Ile Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Phe Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asp Gln Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  32

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Tyr Leu His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Asn Pro Ser Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser His Tyr Asn Asp Tyr Leu Thr Gly Ala Met Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  33
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  33

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Asn Phe 
            20                  25                  30          


Tyr Leu His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Glu Gln Leu Ser Thr Lys Tyr Asn Asp Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Ser His Phe Thr Asp Tyr Leu Thr Gly Ala Met Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  34
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  34

Asp Val Gln Ile Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Ile Phe Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Asp Gln Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  35
<211>  117
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  35

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Val Ser Gly Phe Asn Ile Arg Asp Ile 
            20                  25                  30          


Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ser Gly His Thr Glu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asp Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Glu Asp Tyr Glu Gly Ile Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  36
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  36

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  37
<211>  117
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Thr Val Lys Ile Ser Cys Lys Ala Ser Gly Phe Asn Ile Arg Asp Ile 
            20                  25                  30          


Tyr Ile His Trp Val Gln Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Ser Gly His Thr Glu Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Ala Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Tyr Glu Gly Ile Gly Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  38
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Val Asp Thr His 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  39

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Ala Ile Arg Asn Lys Thr Asn Asn His Ala Thr Tyr Tyr Thr Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gln Gly Asp Gly Tyr Tyr Val Arg Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  40
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  40

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Thr Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  41
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala 
            20                  25                  30          


Trp Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Arg Asn Lys Thr Asn Asn His Ala Thr Tyr Tyr Thr Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Gln Gly Asp Gly Tyr Tyr Val Arg Phe Ala Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  42
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  42

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Thr Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Asp Ala Lys Thr Leu Ala Glu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His His Tyr Gly Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  43
<211>  122
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCVR

<400>  43

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ile Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Thr Glu Tyr Thr Glu Asn Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Phe Phe Gly Ser Ser Pro Asn Trp Tyr Phe Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  44
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCVR

<400>  44

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gly Ala Ser Glu Asn Ile Tyr Gly Ala 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Thr Asn Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Asn Val Leu Asn Thr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  45
<211>  330
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CH

<400>  45

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  46
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CL

<400>  46

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  47
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  47

Asp Tyr His Leu Asp 
1               5   


<210>  48
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  48

Tyr Ile Asp Pro Asp Asn Gly Gly Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  49
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  49

Trp His Asp Tyr Ala Pro Ser Phe Ala Tyr 
1               5                   10  


<210>  50
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  50

His Ala Ser Gln Asn Ile Asn Val Trp Leu Ser 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  51

Lys Ala Ser Asn Leu His Thr 
1               5           


<210>  52
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  52

Gln Gln Gly Gln Ser Tyr Pro Leu Thr 
1               5                   


<210>  53
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  53

Asn Tyr Asp Ile Asn 
1               5   


<210>  54
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  54

Trp Ile Phe Pro Gly Asp Asp Ser Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  55
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  55

Asp Tyr Asp Asn Ser Tyr Val Phe Asp His 
1               5                   10  


<210>  56
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  56

Thr Tyr Asp Leu Asn 
1               5   


<210>  57
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  57

Trp Ile Ser Pro Gly Asp Gly Asn Thr Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  58
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  58

Val Gly Asp Tyr Ser Tyr Tyr Phe Asp Tyr 
1               5                   10  


<210>  59
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  59

His Ala Ser Gln Asn Ile Asn Val Trp Leu Asn 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  60

Lys Ala Ser Asn Leu Tyr Thr 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  61

Gln Gln Gly Gln Ser Phe Pro Leu Thr 
1               5                   


<210>  62
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  62

Asn Tyr Trp Met Asn 
1               5   


<210>  63
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  63

Met Ile His Pro Ser Asp Ser Glu Ile Met Leu Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  64
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  64

Glu Asp Ser Ser Gly Tyr Trp Phe Ala Tyr 
1               5                   10  


<210>  65
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  65

Asn Phe Tyr Leu His 
1               5   


<210>  66
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  66

Trp Ile Tyr Pro Glu Asn Leu Ser Thr Lys Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  67
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  67

Ser His Tyr Asn Asp Tyr Leu Thr Gly Ala Met Asp His 
1               5                   10              


<210>  68
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  68

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  69
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  69

Ser Gly Ser Thr Leu Gln Phe 
1               5           


<210>  70
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  70

Gln Gln His Asp Gln Tyr Pro Trp Thr 
1               5                   


<210>  71
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  71

Asp Ile Tyr Ile His 
1               5   


<210>  72
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  72

Arg Ile Asp Pro Ala Ser Gly His Thr Glu Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Ala 
    


<210>  73
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  73

Glu Asp Tyr Glu Gly Ile Gly Tyr 
1               5               


<210>  74
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  74

Arg Ala Ser Gln Asn Val Asp Thr His Val Ala 
1               5                   10      


<210>  75
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  75

Leu Ala Ser Tyr Arg Tyr Ser 
1               5           


<210>  76
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  76

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  77
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  77

Asp Ala Trp Met Asp 
1               5   


<210>  78
<211>  19
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  78

Ala Ile Arg Asn Lys Thr Asn Asn His Ala Thr Tyr Tyr Thr Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  79
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  79

Gln Gly Asp Gly Tyr Tyr Val Arg Phe Ala Tyr 
1               5                   10      


<210>  80
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  80

Arg Ala Ser Glu Asn Thr Tyr Ser Tyr Leu Ala 
1               5                   10      


<210>  81
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  81

Asp Ala Lys Thr Leu Ala Glu 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  82

Gln His His Tyr Gly Thr Pro Tyr Thr 
1               5                   


<210>  83
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  83

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  84
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  84

Ser Tyr Tyr Leu His 
1               5   


<210>  85
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  85

Trp Ile Tyr Pro Gly Asn Val Asn Thr Asn Tyr Asn Glu Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  86
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  86

Ser Asp Tyr Asp Tyr Asp Ala Met Asp Tyr 
1               5                   10  


<210>  87
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  87

Ser Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  88
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  88

Arg Thr Ser Asn Leu Ala Ser 
1               5           


<210>  89
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR3

<400>  89

Gln Gln Tyr His Ser Tyr Pro Phe Thr 
1               5                   


<210>  90
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  90

Gly Tyr Asp Met His 
1               5   


<210>  91
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  91

Tyr Ile Ser Cys Tyr Asn Gly Gly Thr Lys Tyr Asn Glu Lys Phe Met 
1               5                   10                  15      


Gly 
    


<210>  92
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  92

Glu Gly Asp Asp Gly Val Trp Phe Ala Tyr 
1               5                   10  


<210>  93
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR1

<400>  93

His Ala Ser Gln Asn Ile Asn Val Trp Leu Thr 
1               5                   10      


<210>  94
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR1

<400>  94

Gly Tyr Asp Met Ser 
1               5   


<210>  95
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  95

Tyr Ile Ser Ser Gly Gly Gly Thr Asn Tyr Tyr Pro Asp Ile Val Lys 
1               5                   10                  15      


Gly 
    


<210>  96
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  96

Glu Gly Asp Tyr Gly Tyr Trp Phe Ala Tyr 
1               5                   10  


<210>  97
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  97

Tyr Ile Asp Pro Asp Thr Gly Gly Thr Phe Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  98
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  98

Trp Ile Tyr Pro Glu Asn Pro Ser Thr Lys Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  99
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR2

<400>  99

Trp Ile Tyr Pro Glu Gln Leu Ser Thr Lys Tyr Asn Asp Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  100
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  HCDR3

<400>  100

Ser His Phe Thr Asp Tyr Leu Thr Gly Ala Met Asp His 
1               5                   10              


<210>  101
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  LCDR2

<400>  101

Ser Gly Ser Thr Leu Ile Phe 
1               5           


