                         SEQUENCE LISTING

<110>  CCOA THERAPEUTICS INC.
 
<120>  RAPID AND FACILE ANTIBODY DETECTION USING COVALENTLY IMMOBILIZED 
       SELF-ASSEMBLED POLYPEPTIDES

<130>  10206046-3PCT

<150>  63/015810
<151>  2020-04-27

<160>  12    

<170>  PatentIn version 3.5

<210>  1
<211>  1037
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  AlphaIIb monomeric subunit

<400>  1

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg Gly Gly Gly Ser Gly Gly Gly  Ser Gly Gly Gly Ser  Asp Tyr Lys 
        995                 1000                 1005             


Asp Asp  Asp Asp Lys Gly Asp  Tyr Lys Asp Asp Asp  Asp Lys Ile 
    1010                 1015                 1020             


Asp Tyr  Lys Asp Asp Asp Asp  Lys His His His His  His His 
    1025                 1030                 1035         


<210>  2
<211>  993
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alpha IIb moiety

<400>  2

Met Ala Arg Ala Leu Cys Pro Leu Gln Ala Leu Trp Leu Leu Glu Trp 
1               5                   10                  15      


Val Leu Leu Leu Leu Gly Pro Cys Ala Ala Pro Pro Ala Trp Ala Leu 
            20                  25                  30          


Asn Leu Asp Pro Val Gln Leu Thr Phe Tyr Ala Gly Pro Asn Gly Ser 
        35                  40                  45              


Gln Phe Gly Phe Ser Leu Asp Phe His Lys Asp Ser His Gly Arg Val 
    50                  55                  60                  


Ala Ile Val Val Gly Ala Pro Arg Thr Leu Gly Pro Ser Gln Glu Glu 
65                  70                  75                  80  


Thr Gly Gly Val Phe Leu Cys Pro Trp Arg Ala Glu Gly Gly Gln Cys 
                85                  90                  95      


Pro Ser Leu Leu Phe Asp Leu Arg Asp Glu Thr Arg Asn Val Gly Ser 
            100                 105                 110         


Gln Thr Leu Gln Thr Phe Lys Ala Arg Gln Gly Leu Gly Ala Ser Val 
        115                 120                 125             


Val Ser Trp Ser Asp Val Ile Val Ala Cys Ala Pro Trp Gln His Trp 
    130                 135                 140                 


Asn Val Leu Glu Lys Thr Glu Glu Ala Glu Lys Thr Pro Val Gly Ser 
145                 150                 155                 160 


Cys Phe Leu Ala Gln Pro Glu Ser Gly Arg Arg Ala Glu Tyr Ser Pro 
                165                 170                 175     


Cys Arg Gly Asn Thr Leu Ser Arg Ile Tyr Val Glu Asn Asp Phe Ser 
            180                 185                 190         


Trp Asp Lys Arg Tyr Cys Glu Ala Gly Phe Ser Ser Val Val Thr Gln 
        195                 200                 205             


Ala Gly Glu Leu Val Leu Gly Ala Pro Gly Gly Tyr Tyr Phe Leu Gly 
    210                 215                 220                 


Leu Leu Ala Gln Ala Pro Val Ala Asp Ile Phe Ser Ser Tyr Arg Pro 
225                 230                 235                 240 


Gly Ile Leu Leu Trp His Val Ser Ser Gln Ser Leu Ser Phe Asp Ser 
                245                 250                 255     


Ser Asn Pro Glu Tyr Phe Asp Gly Tyr Trp Gly Tyr Ser Val Ala Val 
            260                 265                 270         


Gly Glu Phe Asp Gly Asp Leu Asn Thr Thr Glu Tyr Val Val Gly Ala 
        275                 280                 285             


Pro Thr Trp Ser Trp Thr Leu Gly Ala Val Glu Ile Leu Asp Ser Tyr 
    290                 295                 300                 


Tyr Gln Arg Leu His Arg Leu Arg Gly Glu Gln Met Ala Ser Tyr Phe 
305                 310                 315                 320 


Gly His Ser Val Ala Val Thr Asp Val Asn Gly Asp Gly Arg His Asp 
                325                 330                 335     


Leu Leu Val Gly Ala Pro Leu Tyr Met Glu Ser Arg Ala Asp Arg Lys 
            340                 345                 350         


Leu Ala Glu Val Gly Arg Val Tyr Leu Phe Leu Gln Pro Arg Gly Pro 
        355                 360                 365             


His Ala Leu Gly Ala Pro Ser Leu Leu Leu Thr Gly Thr Gln Leu Tyr 
    370                 375                 380                 


Gly Arg Phe Gly Ser Ala Ile Ala Pro Leu Gly Asp Leu Asp Arg Asp 
385                 390                 395                 400 


Gly Tyr Asn Asp Ile Ala Val Ala Ala Pro Tyr Gly Gly Pro Ser Gly 
                405                 410                 415     


Arg Gly Gln Val Leu Val Phe Leu Gly Gln Ser Glu Gly Leu Arg Ser 
            420                 425                 430         


Arg Pro Ser Gln Val Leu Asp Ser Pro Phe Pro Thr Gly Ser Ala Phe 
        435                 440                 445             


Gly Phe Ser Leu Arg Gly Ala Val Asp Ile Asp Asp Asn Gly Tyr Pro 
    450                 455                 460                 


Asp Leu Ile Val Gly Ala Tyr Gly Ala Asn Gln Val Ala Val Tyr Arg 
465                 470                 475                 480 


Ala Gln Pro Val Val Lys Ala Ser Val Gln Leu Leu Val Gln Asp Ser 
                485                 490                 495     


Leu Asn Pro Ala Val Lys Ser Cys Val Leu Pro Gln Thr Lys Thr Pro 
            500                 505                 510         


Val Ser Cys Phe Asn Ile Gln Met Cys Val Gly Ala Thr Gly His Asn 
        515                 520                 525             


Ile Pro Gln Lys Leu Ser Leu Asn Ala Glu Leu Gln Leu Asp Arg Gln 
    530                 535                 540                 


Lys Pro Arg Gln Gly Arg Arg Val Leu Leu Leu Gly Ser Gln Gln Ala 
545                 550                 555                 560 


Gly Thr Thr Leu Asn Leu Asp Leu Gly Gly Lys His Ser Pro Ile Cys 
                565                 570                 575     


His Thr Thr Met Ala Phe Leu Arg Asp Glu Ala Asp Phe Arg Asp Lys 
            580                 585                 590         


Leu Ser Pro Ile Val Leu Ser Leu Asn Val Ser Leu Pro Pro Thr Glu 
        595                 600                 605             


Ala Gly Met Ala Pro Ala Val Val Leu His Gly Asp Thr His Val Gln 
    610                 615                 620                 


Glu Gln Thr Arg Ile Val Leu Asp Cys Gly Glu Asp Asp Val Cys Val 
625                 630                 635                 640 


Pro Gln Leu Gln Leu Thr Ala Ser Val Thr Gly Ser Pro Leu Leu Val 
                645                 650                 655     


Gly Ala Asp Asn Val Leu Glu Leu Gln Met Asp Ala Ala Asn Glu Gly 
            660                 665                 670         


Glu Gly Ala Tyr Glu Ala Glu Leu Ala Val His Leu Pro Gln Gly Ala 
        675                 680                 685             


His Tyr Met Arg Ala Leu Ser Asn Val Glu Gly Phe Glu Arg Leu Ile 
    690                 695                 700                 


Cys Asn Gln Lys Lys Glu Asn Glu Thr Arg Val Val Leu Cys Glu Leu 
705                 710                 715                 720 


Gly Asn Pro Met Lys Lys Asn Ala Gln Ile Gly Ile Ala Met Leu Val 
                725                 730                 735     


Ser Val Gly Asn Leu Glu Glu Ala Gly Glu Ser Val Ser Phe Gln Leu 
            740                 745                 750         


Gln Ile Arg Ser Lys Asn Ser Gln Asn Pro Asn Ser Lys Ile Val Leu 
        755                 760                 765             


Leu Asp Val Pro Val Arg Ala Glu Ala Gln Val Glu Leu Arg Gly Asn 
    770                 775                 780                 


Ser Phe Pro Ala Ser Leu Val Val Ala Ala Glu Glu Gly Glu Arg Glu 
785                 790                 795                 800 


Gln Asn Ser Leu Asp Ser Trp Gly Pro Lys Val Glu His Thr Tyr Glu 
                805                 810                 815     


Leu His Asn Asn Gly Pro Gly Thr Val Asn Gly Leu His Leu Ser Ile 
            820                 825                 830         


His Leu Pro Gly Gln Ser Gln Pro Ser Asp Leu Leu Tyr Ile Leu Asp 
        835                 840                 845             


Ile Gln Pro Gln Gly Gly Leu Gln Cys Phe Pro Gln Pro Pro Val Asn 
    850                 855                 860                 


Pro Leu Lys Val Asp Trp Gly Leu Pro Ile Pro Ser Pro Ser Pro Ile 
865                 870                 875                 880 


His Pro Ala His His Lys Arg Asp Arg Arg Gln Ile Phe Leu Pro Glu 
                885                 890                 895     


Pro Glu Gln Pro Ser Arg Leu Gln Asp Pro Val Leu Val Ser Cys Asp 
            900                 905                 910         


Ser Ala Pro Cys Thr Val Val Gln Cys Asp Leu Gln Glu Met Ala Arg 
        915                 920                 925             


Gly Gln Arg Ala Met Val Thr Val Leu Ala Phe Leu Trp Leu Pro Ser 
    930                 935                 940                 


Leu Tyr Gln Arg Pro Leu Asp Gln Phe Val Leu Gln Ser His Ala Trp 
945                 950                 955                 960 


Phe Asn Val Ser Ser Leu Pro Tyr Ala Val Pro Pro Leu Ser Leu Pro 
                965                 970                 975     


Arg Gly Glu Ala Gln Val Trp Thr Gln Leu Leu Arg Ala Leu Glu Glu 
            980                 985                 990         


Arg 
    


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for AlphaIIb

<400>  3

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10          


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Acidic tail for AlphaIIb

<400>  4

Asp Tyr Lys Asp Asp Asp Asp Lys Gly Asp Tyr Lys Asp Asp Asp Asp 
1               5                   10                  15      


Lys Ile Asp Tyr Lys Asp Asp Asp Asp Lys 
            20                  25      


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Histidine tag for AlphaIIb

<400>  5

His His His His His His 
1               5       


<210>  6
<211>  744
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta3 monomeric subunit

<400>  6

Gly Pro Asn Ile Cys Thr Thr Arg Gly Val Ser Ser Cys Gln Gln Cys 
1               5                   10                  15      


Leu Ala Val Ser Pro Met Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro 
            20                  25                  30          


Leu Gly Ser Pro Arg Cys Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn 
        35                  40                  45              


Cys Ala Pro Glu Ser Ile Glu Phe Pro Val Ser Glu Ala Arg Val Leu 
    50                  55                  60                  


Glu Asp Arg Pro Leu Ser Asp Lys Gly Ser Gly Asp Ser Ser Gln Val 
65                  70                  75                  80  


Thr Gln Val Ser Pro Gln Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp 
                85                  90                  95      


Ser Lys Asn Phe Ser Ile Gln Val Arg Gln Val Glu Asp Tyr Pro Val 
            100                 105                 110         


Asp Ile Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu 
        115                 120                 125             


Trp Ser Ile Gln Asn Leu Gly Thr Lys Leu Ala Thr Gln Met Arg Lys 
    130                 135                 140                 


Leu Thr Ser Asn Leu Arg Ile Gly Phe Gly Ala Phe Val Asp Lys Pro 
145                 150                 155                 160 


Val Ser Pro Tyr Met Tyr Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro 
                165                 170                 175     


Cys Tyr Asp Met Lys Thr Thr Cys Leu Pro Met Phe Gly Tyr Lys His 
            180                 185                 190         


Val Leu Thr Leu Thr Asp Gln Val Thr Arg Phe Asn Glu Glu Val Lys 
        195                 200                 205             


Lys Gln Ser Val Ser Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp 
    210                 215                 220                 


Ala Ile Met Gln Ala Thr Val Cys Asp Glu Lys Ile Gly Trp Arg Asn 
225                 230                 235                 240 


Asp Ala Ser His Leu Leu Val Phe Thr Thr Asp Ala Lys Thr His Ile 
                245                 250                 255     


Ala Leu Asp Gly Arg Leu Ala Gly Ile Val Gln Pro Asn Asp Gly Gln 
            260                 265                 270         


Cys His Val Gly Ser Asp Asn His Tyr Ser Ala Ser Thr Thr Met Asp 
        275                 280                 285             


Tyr Pro Ser Leu Gly Leu Met Thr Glu Lys Leu Ser Gln Lys Asn Ile 
    290                 295                 300                 


Asn Leu Ile Phe Ala Val Thr Glu Asn Val Val Asn Leu Tyr Gln Asn 
305                 310                 315                 320 


Tyr Ser Glu Leu Ile Pro Gly Thr Thr Val Gly Val Leu Ser Met Asp 
                325                 330                 335     


Ser Ser Asn Val Leu Gln Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg 
            340                 345                 350         


Ser Lys Val Glu Leu Glu Val Arg Asp Leu Pro Glu Glu Leu Ser Leu 
        355                 360                 365             


Ser Phe Asn Ala Thr Cys Leu Asn Asn Glu Val Ile Pro Gly Leu Lys 
    370                 375                 380                 


Ser Cys Met Gly Leu Lys Ile Gly Asp Thr Val Ser Phe Ser Ile Glu 
385                 390                 395                 400 


Ala Lys Val Arg Gly Cys Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile 
                405                 410                 415     


Lys Pro Val Gly Phe Lys Asp Ser Leu Ile Val Gln Val Thr Phe Asp 
            420                 425                 430         


Cys Asp Cys Ala Cys Gln Ala Gln Ala Glu Pro Asn Ser His Arg Cys 
        435                 440                 445             


Asn Asn Gly Asn Gly Thr Phe Glu Cys Gly Val Cys Arg Cys Gly Pro 
    450                 455                 460                 


Gly Trp Leu Gly Ser Gln Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro 
465                 470                 475                 480 


Ser Gln Gln Asp Glu Cys Ser Pro Arg Glu Gly Gln Pro Val Cys Ser 
                485                 490                 495     


Gln Arg Gly Glu Cys Leu Cys Gly Gln Cys Val Cys His Ser Ser Asp 
            500                 505                 510         


Phe Gly Lys Ile Thr Gly Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys 
        515                 520                 525             


Val Arg Tyr Lys Gly Glu Met Cys Ser Gly His Gly Gln Cys Ser Cys 
    530                 535                 540                 


Gly Asp Cys Leu Cys Asp Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys 
545                 550                 555                 560 


Thr Thr Arg Thr Asp Thr Cys Met Ser Ser Asn Gly Leu Leu Cys Ser 
                565                 570                 575     


Gly Arg Gly Lys Cys Glu Cys Gly Ser Cys Val Cys Ile Gln Pro Gly 
            580                 585                 590         


Ser Tyr Gly Asp Thr Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys 
        595                 600                 605             


Thr Phe Lys Lys Glu Cys Val Glu Cys Lys Lys Phe Asp Arg Gly Ala 
    610                 615                 620                 


Leu His Asp Glu Asn Thr Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu 
625                 630                 635                 640 


Ser Val Lys Glu Leu Lys Asp Thr Gly Lys Asp Ala Val Asn Cys Thr 
                645                 650                 655     


Tyr Lys Asn Glu Asp Asp Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp 
            660                 665                 670         


Ser Ser Gly Lys Ser Ile Leu Tyr Val Val Glu Glu Pro Glu Cys Pro 
        675                 680                 685             


Lys Gly Pro Asp His Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
    690                 695                 700                 


Gly Ser Trp Lys Lys Tyr Lys Lys Ser Asp Pro Gly Trp Lys Lys Tyr 
705                 710                 715                 720 


Lys Lys Ser Asp Gly Gly Trp Lys Lys Tyr Lys Lys Ser Asp Pro Gly 
                725                 730                 735     


Trp Lys Lys Tyr Lys Trp Ser Asp 
            740                 


<210>  7
<211>  692
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta3 moiety

<400>  7

Gly Pro Asn Ile Cys Thr Thr Arg Gly Val Ser Ser Cys Gln Gln Cys 
1               5                   10                  15      


Leu Ala Val Ser Pro Met Cys Ala Trp Cys Ser Asp Glu Ala Leu Pro 
            20                  25                  30          


Leu Gly Ser Pro Arg Cys Asp Leu Lys Glu Asn Leu Leu Lys Asp Asn 
        35                  40                  45              


Cys Ala Pro Glu Ser Ile Glu Phe Pro Val Ser Glu Ala Arg Val Leu 
    50                  55                  60                  


Glu Asp Arg Pro Leu Ser Asp Lys Gly Ser Gly Asp Ser Ser Gln Val 
65                  70                  75                  80  


Thr Gln Val Ser Pro Gln Arg Ile Ala Leu Arg Leu Arg Pro Asp Asp 
                85                  90                  95      


Ser Lys Asn Phe Ser Ile Gln Val Arg Gln Val Glu Asp Tyr Pro Val 
            100                 105                 110         


Asp Ile Tyr Tyr Leu Met Asp Leu Ser Tyr Ser Met Lys Asp Asp Leu 
        115                 120                 125             


Trp Ser Ile Gln Asn Leu Gly Thr Lys Leu Ala Thr Gln Met Arg Lys 
    130                 135                 140                 


Leu Thr Ser Asn Leu Arg Ile Gly Phe Gly Ala Phe Val Asp Lys Pro 
145                 150                 155                 160 


Val Ser Pro Tyr Met Tyr Ile Ser Pro Pro Glu Ala Leu Glu Asn Pro 
                165                 170                 175     


Cys Tyr Asp Met Lys Thr Thr Cys Leu Pro Met Phe Gly Tyr Lys His 
            180                 185                 190         


Val Leu Thr Leu Thr Asp Gln Val Thr Arg Phe Asn Glu Glu Val Lys 
        195                 200                 205             


Lys Gln Ser Val Ser Arg Asn Arg Asp Ala Pro Glu Gly Gly Phe Asp 
    210                 215                 220                 


Ala Ile Met Gln Ala Thr Val Cys Asp Glu Lys Ile Gly Trp Arg Asn 
225                 230                 235                 240 


Asp Ala Ser His Leu Leu Val Phe Thr Thr Asp Ala Lys Thr His Ile 
                245                 250                 255     


Ala Leu Asp Gly Arg Leu Ala Gly Ile Val Gln Pro Asn Asp Gly Gln 
            260                 265                 270         


Cys His Val Gly Ser Asp Asn His Tyr Ser Ala Ser Thr Thr Met Asp 
        275                 280                 285             


Tyr Pro Ser Leu Gly Leu Met Thr Glu Lys Leu Ser Gln Lys Asn Ile 
    290                 295                 300                 


Asn Leu Ile Phe Ala Val Thr Glu Asn Val Val Asn Leu Tyr Gln Asn 
305                 310                 315                 320 


Tyr Ser Glu Leu Ile Pro Gly Thr Thr Val Gly Val Leu Ser Met Asp 
                325                 330                 335     


Ser Ser Asn Val Leu Gln Leu Ile Val Asp Ala Tyr Gly Lys Ile Arg 
            340                 345                 350         


Ser Lys Val Glu Leu Glu Val Arg Asp Leu Pro Glu Glu Leu Ser Leu 
        355                 360                 365             


Ser Phe Asn Ala Thr Cys Leu Asn Asn Glu Val Ile Pro Gly Leu Lys 
    370                 375                 380                 


Ser Cys Met Gly Leu Lys Ile Gly Asp Thr Val Ser Phe Ser Ile Glu 
385                 390                 395                 400 


Ala Lys Val Arg Gly Cys Pro Gln Glu Lys Glu Lys Ser Phe Thr Ile 
                405                 410                 415     


Lys Pro Val Gly Phe Lys Asp Ser Leu Ile Val Gln Val Thr Phe Asp 
            420                 425                 430         


Cys Asp Cys Ala Cys Gln Ala Gln Ala Glu Pro Asn Ser His Arg Cys 
        435                 440                 445             


Asn Asn Gly Asn Gly Thr Phe Glu Cys Gly Val Cys Arg Cys Gly Pro 
    450                 455                 460                 


Gly Trp Leu Gly Ser Gln Cys Glu Cys Ser Glu Glu Asp Tyr Arg Pro 
465                 470                 475                 480 


Ser Gln Gln Asp Glu Cys Ser Pro Arg Glu Gly Gln Pro Val Cys Ser 
                485                 490                 495     


Gln Arg Gly Glu Cys Leu Cys Gly Gln Cys Val Cys His Ser Ser Asp 
            500                 505                 510         


Phe Gly Lys Ile Thr Gly Lys Tyr Cys Glu Cys Asp Asp Phe Ser Cys 
        515                 520                 525             


Val Arg Tyr Lys Gly Glu Met Cys Ser Gly His Gly Gln Cys Ser Cys 
    530                 535                 540                 


Gly Asp Cys Leu Cys Asp Ser Asp Trp Thr Gly Tyr Tyr Cys Asn Cys 
545                 550                 555                 560 


Thr Thr Arg Thr Asp Thr Cys Met Ser Ser Asn Gly Leu Leu Cys Ser 
                565                 570                 575     


Gly Arg Gly Lys Cys Glu Cys Gly Ser Cys Val Cys Ile Gln Pro Gly 
            580                 585                 590         


Ser Tyr Gly Asp Thr Cys Glu Lys Cys Pro Thr Cys Pro Asp Ala Cys 
        595                 600                 605             


Thr Phe Lys Lys Glu Cys Val Glu Cys Lys Lys Phe Asp Arg Gly Ala 
    610                 615                 620                 


Leu His Asp Glu Asn Thr Cys Asn Arg Tyr Cys Arg Asp Glu Ile Glu 
625                 630                 635                 640 


Ser Val Lys Glu Leu Lys Asp Thr Gly Lys Asp Ala Val Asn Cys Thr 
                645                 650                 655     


Tyr Lys Asn Glu Asp Asp Cys Val Val Arg Phe Gln Tyr Tyr Glu Asp 
            660                 665                 670         


Ser Ser Gly Lys Ser Ile Leu Tyr Val Val Glu Glu Pro Glu Cys Pro 
        675                 680                 685             


Lys Gly Pro Asp 
    690         


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker for Beta3

<400>  8

His Pro Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  


<210>  9
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basic tail for Beta3

<400>  9

Arg Phe Gln Tyr Tyr Glu Asp Ser Ser Gly Lys Ser Ile Leu Tyr Val 
1               5                   10                  15      


Val Glu Glu Pro Glu Cys Pro Lys Gly Pro Asp His Pro Gly Gly Gly 
            20                  25                  30          


Ser Gly Gly Gly Ser Gly Gly Gly Ser Trp Lys Lys Tyr Lys Lys Ser 
        35                  40                  45              


Asp Pro Gly Trp Lys Lys Tyr Lys Lys Ser Asp Gly Gly Trp Lys Lys 
    50                  55                  60                  


Tyr Lys Lys Ser Asp Pro Gly Trp Lys Lys Tyr Lys Trp Ser Asp 
65                  70                  75                  


<210>  10
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPIbalpha chimeric unit

<400>  10

His Pro His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu 
1               5                   10                  15      


Val Asn Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro 
            20                  25                  30          


Lys Asp Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe 
        35                  40                  45              


Ser Leu Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu 
    50                  55                  60                  


Asp Arg Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val 
65                  70                  75                  80  


Leu Gly Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu 
                85                  90                  95      


Leu Gly Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn 
            100                 105                 110         


Arg Leu Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu 
        115                 120                 125             


Gln Glu Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly 
    130                 135                 140                 


Leu Leu Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn 
145                 150                 155                 160 


Asn Leu Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu 
                165                 170                 175     


Asp Thr Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly 
            180                 185                 190         


Phe Phe Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro 
        195                 200                 205             


Trp Leu Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp 
    210                 215                 220                 


Asn Ala Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala 
225                 230                 235                 240 


Met Thr Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe 
                245                 250                 255     


Pro Val Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu 
            260                 265                 270         


Gly Asp Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly 
        275                 280                 285             


Asp Lys Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala 
    290                 295                 300                 


His Thr Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu 
305                 310                 315                 320 


Asp Ser Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys 
                325                 330                 335     


Glu Gln Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His 
            340                 345                 350         


Met Glu Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro 
        355                 360                 365             


Thr Pro Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn 
    370                 375                 380                 


Met Thr Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr 
385                 390                 395                 400 


Ser Glu Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro 
                405                 410                 415     


Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro Ser 
            420                 425                 430         


Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile Ala Thr Ser Pro 
        435                 440                 445             


Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro Lys Ser Thr Phe 
    450                 455                 460                 


Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser Thr Lys Lys Thr 
465                 470                 475                 480 


Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu Gly Pro Asp Tyr Lys Asp 
                485                 490                 495     


Asp Asp Asp Lys 
            500 


<210>  11
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  GPIbalpha moiety

<400>  11

His Pro His Pro Ile Cys Glu Val Ser Lys Val Ala Ser His Leu Glu 
1               5                   10                  15      


Val Asn Cys Asp Lys Arg Asn Leu Thr Ala Leu Pro Pro Asp Leu Pro 
            20                  25                  30          


Lys Asp Thr Thr Ile Leu His Leu Ser Glu Asn Leu Leu Tyr Thr Phe 
        35                  40                  45              


Ser Leu Ala Thr Leu Met Pro Tyr Thr Arg Leu Thr Gln Leu Asn Leu 
    50                  55                  60                  


Asp Arg Cys Glu Leu Thr Lys Leu Gln Val Asp Gly Thr Leu Pro Val 
65                  70                  75                  80  


Leu Gly Thr Leu Asp Leu Ser His Asn Gln Leu Gln Ser Leu Pro Leu 
                85                  90                  95      


Leu Gly Gln Thr Leu Pro Ala Leu Thr Val Leu Asp Val Ser Phe Asn 
            100                 105                 110         


Arg Leu Thr Ser Leu Pro Leu Gly Ala Leu Arg Gly Leu Gly Glu Leu 
        115                 120                 125             


Gln Glu Leu Tyr Leu Lys Gly Asn Glu Leu Lys Thr Leu Pro Pro Gly 
    130                 135                 140                 


Leu Leu Thr Pro Thr Pro Lys Leu Glu Lys Leu Ser Leu Ala Asn Asn 
145                 150                 155                 160 


Asn Leu Thr Glu Leu Pro Ala Gly Leu Leu Asn Gly Leu Glu Asn Leu 
                165                 170                 175     


Asp Thr Leu Leu Leu Gln Glu Asn Ser Leu Tyr Thr Ile Pro Lys Gly 
            180                 185                 190         


Phe Phe Gly Ser His Leu Leu Pro Phe Ala Phe Leu His Gly Asn Pro 
        195                 200                 205             


Trp Leu Cys Asn Cys Glu Ile Leu Tyr Phe Arg Arg Trp Leu Gln Asp 
    210                 215                 220                 


Asn Ala Glu Asn Val Tyr Val Trp Lys Gln Gly Val Asp Val Lys Ala 
225                 230                 235                 240 


Met Thr Ser Asn Val Ala Ser Val Gln Cys Asp Asn Ser Asp Lys Phe 
                245                 250                 255     


Pro Val Tyr Lys Tyr Pro Gly Lys Gly Cys Pro Thr Leu Gly Asp Glu 
            260                 265                 270         


Gly Asp Thr Asp Leu Tyr Asp Tyr Tyr Pro Glu Glu Asp Thr Glu Gly 
        275                 280                 285             


Asp Lys Val Arg Ala Thr Arg Thr Val Val Lys Phe Pro Thr Lys Ala 
    290                 295                 300                 


His Thr Thr Pro Trp Gly Leu Phe Tyr Ser Trp Ser Thr Ala Ser Leu 
305                 310                 315                 320 


Asp Ser Gln Met Pro Ser Ser Leu His Pro Thr Gln Glu Ser Thr Lys 
                325                 330                 335     


Glu Gln Thr Thr Phe Pro Pro Arg Trp Thr Pro Asn Phe Thr Leu His 
            340                 345                 350         


Met Glu Ser Ile Thr Phe Ser Lys Thr Pro Lys Ser Thr Thr Glu Pro 
        355                 360                 365             


Thr Pro Ser Pro Thr Thr Ser Glu Pro Val Pro Glu Pro Ala Pro Asn 
    370                 375                 380                 


Met Thr Thr Leu Glu Pro Thr Pro Ser Pro Thr Thr Pro Glu Pro Thr 
385                 390                 395                 400 


Ser Glu Pro Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro 
                405                 410                 415     


Ala Pro Ser Pro Thr Thr Pro Glu Pro Thr Ser Glu Pro Ala Pro Ser 
            420                 425                 430         


Pro Thr Thr Pro Glu Pro Thr Pro Ile Pro Thr Ile Ala Thr Ser Pro 
        435                 440                 445             


Thr Ile Leu Val Ser Ala Thr Ser Leu Ile Thr Pro Lys Ser Thr Phe 
    450                 455                 460                 


Leu Thr Thr Thr Lys Pro Val Ser Leu Leu Glu Ser Thr Lys Lys Thr 
465                 470                 475                 480 


Ile Pro Glu Leu Asp Gln Pro Pro Lys Leu 
                485                 490 


<210>  12
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flat tag for GPlbalpha

<400>  12

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


