                         SEQUENCE LISTING

<110>  University of Virginia Patent Foundation
       Zimring, James C.
       Bazydlo, Lindsay Ann Legendre
       Wiencek, Joesph Richard
       Gorham, James David
       Howie, Heather
 
<120>  SPECIFICITY ENHANCING REAGENTS FOR COVID-19 ANTIBODY TESTING

<130>  3062/127 PCT

<150>  63/015,215
<151>  2020-04-24

<160>  63    

<170>  PatentIn version 3.3

<210>  1
<211>  1347
<212>  DNA
<213>  Coronavirus

<400>  1
atgtctttta ctcctggtaa gcaatccagt agtagagcgt cctctggaaa tcgttctggt     60

aatggcatcc tcaagtgggc cgatcagtcc gaccagttta gaaatgttca aaccaggggt    120

agaagagctc aacccaagca aactgctacc tctcagcaac catcaggagg gaatgttgta    180

ccctactatt cttggttctc tggaattact cagtttcaaa agggaaagga gtttgagttt    240

gtagaaggac aaggtgtgcc tattgcacca ggagtcccag ctactgaagc taaggggtac    300

tggtacagac acaacagacg ttcttttaaa acagccgatg gcaaccagcg tcaactgctg    360

ccacgatggt atttttacta tctgggaaca ggaccgcatg ctaaagacca gtacggcacc    420

gatattgacg gagtctactg ggtcgctagc aaccaggctg atgtcaatac cccggctgac    480

attgtcgatc gggacccaag tagcgatgag gctattccga ctaggtttcc gcctggcacg    540

gtactccctc agggttacta tattgaaggc tcaggaaggt ctgctcctaa ttccagatct    600

acttcgcgca catccagcag agcctctagt gcaggatcgc gtagtagagc caattctggc    660

aatagaaccc ctacctctgg tgtaacacct gacatggctg atcaaattgc tagtcttgtt    720

ctggcaaaac ttggcaagga tgccactaaa cctcagcaag taactaagca tactgccaaa    780

gaagtcagac agaaaatttt gaataagccc cgccagaaga ggagccccaa taaacaatgc    840

actgttcagc agtgttttgg taagagaggc cctaatcaga attttggtgg tggagaaatg    900

ttaaaacttg gaactagtga cccacagttc cccattcttg cagaactcgc acccacagct    960

ggtgcgtttt tctttggatc aagattagag ttggccaaag tgcagaattt atctgggaat   1020

cctgacgagc cccagaagga tgtttatgaa ttgcgctata acggcgcaat taggtttgac   1080

agtacacttt caggttttga gaccataatg aaggtgctga atgagaattt gaatgcctat   1140

caacaacaag atggtatgat gaatatgagt ccaaaaccac agcgtcagcg tggtcataag   1200

aatggacaag gagaaaatga taatataagt gttgcagtgc ccaaaagccg cgtgcagcaa   1260

aataagagta gagagttgac tgcagaggac atcagccttc ttaagaagat ggatgagccc   1320

tatactgaag acacctcaga aatataa                                       1347


<210>  2
<211>  448
<212>  PRT
<213>  coronavirus

<400>  2

Met Ser Phe Thr Pro Gly Lys Gln Ser Ser Ser Arg Ala Ser Ser Gly 
1               5                   10                  15      


Asn Arg Ser Gly Asn Gly Ile Leu Lys Trp Ala Asp Gln Ser Asp Gln 
            20                  25                  30          


Phe Arg Asn Val Gln Thr Arg Gly Arg Arg Ala Gln Pro Lys Gln Thr 
        35                  40                  45              


Ala Thr Ser Gln Gln Pro Ser Gly Gly Asn Val Val Pro Tyr Tyr Ser 
    50                  55                  60                  


Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Glu Phe 
65                  70                  75                  80  


Val Glu Gly Gln Gly Val Pro Ile Ala Pro Gly Val Pro Ala Thr Glu 
                85                  90                  95      


Ala Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Ala 
            100                 105                 110         


Asp Gly Asn Gln Arg Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu 
        115                 120                 125             


Gly Thr Gly Pro His Ala Lys Asp Gln Tyr Gly Thr Asp Ile Asp Gly 
    130                 135                 140                 


Val Tyr Trp Val Ala Ser Asn Gln Ala Asp Val Asn Thr Pro Ala Asp 
145                 150                 155                 160 


Ile Val Asp Arg Asp Pro Ser Ser Asp Glu Ala Ile Pro Thr Arg Phe 
                165                 170                 175     


Pro Pro Gly Thr Val Leu Pro Gln Gly Tyr Tyr Ile Glu Gly Ser Gly 
            180                 185                 190         


Arg Ser Ala Pro Asn Ser Arg Ser Thr Ser Arg Thr Ser Ser Arg Ala 
        195                 200                 205             


Ser Ser Ala Gly Ser Arg Ser Arg Ala Asn Ser Gly Asn Arg Thr Pro 
    210                 215                 220                 


Thr Ser Gly Val Thr Pro Asp Met Ala Asp Gln Ile Ala Ser Leu Val 
225                 230                 235                 240 


Leu Ala Lys Leu Gly Lys Asp Ala Thr Lys Pro Gln Gln Val Thr Lys 
                245                 250                 255     


His Thr Ala Lys Glu Val Arg Gln Lys Ile Leu Asn Lys Pro Arg Gln 
            260                 265                 270         


Lys Arg Ser Pro Asn Lys Gln Cys Thr Val Gln Gln Cys Phe Gly Lys 
        275                 280                 285             


Arg Gly Pro Asn Gln Asn Phe Gly Gly Gly Glu Met Leu Lys Leu Gly 
    290                 295                 300                 


Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Ala 
305                 310                 315                 320 


Gly Ala Phe Phe Phe Gly Ser Arg Leu Glu Leu Ala Lys Val Gln Asn 
                325                 330                 335     


Leu Ser Gly Asn Pro Asp Glu Pro Gln Lys Asp Val Tyr Glu Leu Arg 
            340                 345                 350         


Tyr Asn Gly Ala Ile Arg Phe Asp Ser Thr Leu Ser Gly Phe Glu Thr 
        355                 360                 365             


Ile Met Lys Val Leu Asn Glu Asn Leu Asn Ala Tyr Gln Gln Gln Asp 
    370                 375                 380                 


Gly Met Met Asn Met Ser Pro Lys Pro Gln Arg Gln Arg Gly His Lys 
385                 390                 395                 400 


Asn Gly Gln Gly Glu Asn Asp Asn Ile Ser Val Ala Val Pro Lys Ser 
                405                 410                 415     


Arg Val Gln Gln Asn Lys Ser Arg Glu Leu Thr Ala Glu Asp Ile Ser 
            420                 425                 430         


Leu Leu Lys Lys Met Asp Glu Pro Tyr Thr Glu Asp Thr Ser Glu Ile 
        435                 440                 445             


<210>  3
<211>  1326
<212>  DNA
<213>  coronavirus

<400>  3
atgtcttata ctcccggtca ttatgctgga agtagaagct cctctggaaa tcgttcagga     60

atcctcaaga aaacttcttg ggctgaccaa tctgagcgaa attaccaaac ctttaataga    120

ggcagaaaaa cccaacctaa attcactgtg tctactcaac cacaaggaaa tactatccca    180

cattattcct ggttctccgg gatcactcaa tttcaaaaag gtagagactt taaattttca    240

gatggtcaag gagttcccat tgctttcgga gtaccccctt ctgaagcaaa aggatattgg    300

tatagacaca gccggcgttc ttttaaaaca gctgatggtc aacaaaagca gttgttaccg    360

agatggtatt tctactatct cggtaccggc ccatatgcca atgcatccta tggtgaatcc    420

ctcgaagggg tcttctgggt tgctaatcac caagctgaca cttctactcc ctccgatgtt    480

tcgtcaaggg atcctactac tcaagaagct atccctacta ggtttccgcc tggtacgatt    540

ttgcctcaag gctattatgt tgaaggctca ggaaggtctg cttctaatag tcgaccaggt    600

tcacgttctc aatcacgtgg acccaataat cgttcattaa gtagaagtaa ttctaatttt    660

agacattcag attctatagt aaaacctgat atggctgatg agatcgctaa tcttgtttta    720

gccaagcttg gtaaagattc taaacctcag caagtcacta agcaaaatgc caaggaaatc    780

aggcataaaa ttttaacaaa acctcgccaa aagcgaactc ctaataaaca ttgtaatgtt    840

caacagtgtt ttggtaaaag aggaccttct caaaattttg gtaatgctga aatgttaaag    900

cttggtacta atgatcctca gtttcctatt cttgcagaat tagctcctac accaggtgct    960

tttttctttg gttctaaatt agacttggtt aaaagagatt ccgaggctga ctcacctgtt   1020

aaagatgttt ttgaacttca ttattctggt tctattaggt ttgatagtac tttaccaggc   1080

tttgagacaa ttatgaaagt tcttgaagag aatttaaatg cttacgttaa ttctaatcag   1140

aacactgatt ctgattcgtt gagttctaaa cctcagcgta aaagaggtgt taaacaatta   1200

ccagaacagt ttgactctct taatttaagt gctggtactc agcacatttc aaatgatttt   1260

actcctgagg atcatagttt acttgctact cttgatgatc cttatgtaga agactctgtt   1320

gcttaa                                                              1326


<210>  4
<211>  448
<212>  PRT
<213>  coronavirus

<400>  4

Met Ser Phe Thr Pro Gly Lys Gln Ser Ser Ser Arg Ala Ser Ser Gly 
1               5                   10                  15      


Asn Arg Ser Gly Asn Gly Ile Leu Lys Trp Ala Asp Gln Ser Asp Gln 
            20                  25                  30          


Phe Arg Asn Val Gln Thr Arg Gly Arg Arg Ala Gln Pro Lys Gln Thr 
        35                  40                  45              


Ala Thr Ser Gln Gln Pro Ser Gly Gly Asn Val Val Pro Tyr Tyr Ser 
    50                  55                  60                  


Trp Phe Ser Gly Ile Thr Gln Phe Gln Lys Gly Lys Glu Phe Glu Phe 
65                  70                  75                  80  


Val Glu Gly Gln Gly Val Pro Ile Ala Pro Gly Val Pro Ala Thr Glu 
                85                  90                  95      


Ala Lys Gly Tyr Trp Tyr Arg His Asn Arg Arg Ser Phe Lys Thr Ala 
            100                 105                 110         


Asp Gly Asn Gln Arg Gln Leu Leu Pro Arg Trp Tyr Phe Tyr Tyr Leu 
        115                 120                 125             


Gly Thr Gly Pro His Ala Lys Asp Gln Tyr Gly Thr Asp Ile Asp Gly 
    130                 135                 140                 


Val Tyr Trp Val Ala Ser Asn Gln Ala Asp Val Asn Thr Pro Ala Asp 
145                 150                 155                 160 


Ile Val Asp Arg Asp Pro Ser Ser Asp Glu Ala Ile Pro Thr Arg Phe 
                165                 170                 175     


Pro Pro Gly Thr Val Leu Pro Gln Gly Tyr Tyr Ile Glu Gly Ser Gly 
            180                 185                 190         


Arg Ser Ala Pro Asn Ser Arg Ser Thr Ser Arg Thr Ser Ser Arg Ala 
        195                 200                 205             


Ser Ser Ala Gly Ser Arg Ser Arg Ala Asn Ser Gly Asn Arg Thr Pro 
    210                 215                 220                 


Thr Ser Gly Val Thr Pro Asp Met Ala Asp Gln Ile Ala Ser Leu Val 
225                 230                 235                 240 


Leu Ala Lys Leu Gly Lys Asp Ala Thr Lys Pro Gln Gln Val Thr Lys 
                245                 250                 255     


His Thr Ala Lys Glu Val Arg Gln Lys Ile Leu Asn Lys Pro Arg Gln 
            260                 265                 270         


Lys Arg Ser Pro Asn Lys Gln Cys Thr Val Gln Gln Cys Phe Gly Lys 
        275                 280                 285             


Arg Gly Pro Asn Gln Asn Phe Gly Gly Gly Glu Met Leu Lys Leu Gly 
    290                 295                 300                 


Thr Ser Asp Pro Gln Phe Pro Ile Leu Ala Glu Leu Ala Pro Thr Ala 
305                 310                 315                 320 


Gly Ala Phe Phe Phe Gly Ser Arg Leu Glu Leu Ala Lys Val Gln Asn 
                325                 330                 335     


Leu Ser Gly Asn Pro Asp Glu Pro Gln Lys Asp Val Tyr Glu Leu Arg 
            340                 345                 350         


Tyr Asn Gly Ala Ile Arg Phe Asp Ser Thr Leu Ser Gly Phe Glu Thr 
        355                 360                 365             


Ile Met Lys Val Leu Asn Glu Asn Leu Asn Ala Tyr Gln Gln Gln Asp 
    370                 375                 380                 


Gly Met Met Asn Met Ser Pro Lys Pro Gln Arg Gln Arg Gly His Lys 
385                 390                 395                 400 


Asn Gly Gln Gly Glu Asn Asp Asn Ile Ser Val Ala Val Pro Lys Ser 
                405                 410                 415     


Arg Val Gln Gln Asn Lys Ser Arg Glu Leu Thr Ala Glu Asp Ile Ser 
            420                 425                 430         


Leu Leu Lys Lys Met Asp Glu Pro Tyr Thr Glu Asp Thr Ser Glu Ile 
        435                 440                 445             


<210>  5
<211>  1134
<212>  DNA
<213>  coronaviurs

<400>  5
atggctagtg taaattgggc cgatgacaga gctgctagga agaaatttcc tcctccttca     60

ttttacatgc ctcttttggt tagttctgat aaggcaccat atagggtcat tcccaggaat    120

cttgtcccta ttggtaaggg taataaagat gagcagattg gttattggaa tgttcaagag    180

cgttggcgta tgcgcagggg gcaacgtgtt gatttgcctc ctaaagttca tttttattac    240

ctaggtactg gacctcataa ggaccttaaa ttcagacaac gttctgatgg tgttgtttgg    300

gttgctaagg aaggtgctaa aactgttaat accagtcttg gtaatcgcaa acgtaatcag    360

aaacctttgg aaccaaagtt ctctattgct ttgcctccag agctctctgt tgttgagttt    420

gaggatcgct ctaataactc atctcgtgct agcagtcgtt cttcaactcg taacaactca    480

cgagactctt ctcgtagcac ttcaagacaa cagtctcgca ctcgttctga ttctaaccag    540

tcttcttcag atcttgttgc tgctgttact ttggctttaa agaacttagg ttttgataac    600

cagtcgaagt cacctagttc ttctggtact tccactccta agaaacctaa taagcctctt    660

tctcaaccca gggctgataa gccttctcag ttgaagaaac ctcgttggaa gcgtgttcct    720

accagagagg aaaatgttat tcagtgcttt ggtcctcgtg attttaatca caatatgggg    780

gattcagatc ttgttcagaa tggtgttgat gccaaaggtt ttccacagct tgctgaattg    840

attcctaatc aggctgcgtt attctttgat agtgaggtta gcactgatga agtgggtgat    900

aatgttcaga ttacctacac ctacaaaatg cttgtagcta aggataataa gaaccttcct    960

aagttcattg agcagattag tgcttttact aaacccagtt ctatcaaaga aatgcagtca   1020

caatcatctc atgttgctca gaacacagta cttaatgctt ctattccaga atctaaacca   1080

ttggctgatg atgattcagc cattatagaa attgtcaacg aggttttgca ttaa         1134


<210>  6
<211>  377
<212>  PRT
<213>  coronavirus

<400>  6

Met Ala Ser Val Asn Trp Ala Asp Asp Arg Ala Ala Arg Lys Lys Phe 
1               5                   10                  15      


Pro Pro Pro Ser Phe Tyr Met Pro Leu Leu Val Ser Ser Asp Lys Ala 
            20                  25                  30          


Pro Tyr Arg Val Ile Pro Arg Asn Leu Val Pro Ile Gly Lys Gly Asn 
        35                  40                  45              


Lys Asp Glu Gln Ile Gly Tyr Trp Asn Val Gln Glu Arg Trp Arg Met 
    50                  55                  60                  


Arg Arg Gly Gln Arg Val Asp Leu Pro Pro Lys Val His Phe Tyr Tyr 
65                  70                  75                  80  


Leu Gly Thr Gly Pro His Lys Asp Leu Lys Phe Arg Gln Arg Ser Asp 
                85                  90                  95      


Gly Val Val Trp Val Ala Lys Glu Gly Ala Lys Thr Val Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Arg Lys Arg Asn Gln Lys Pro Leu Glu Pro Lys Phe Ser 
        115                 120                 125             


Ile Ala Leu Pro Pro Glu Leu Ser Val Val Glu Phe Glu Asp Arg Ser 
    130                 135                 140                 


Asn Asn Ser Ser Arg Ala Ser Ser Arg Ser Ser Thr Arg Asn Asn Ser 
145                 150                 155                 160 


Arg Asp Ser Ser Arg Ser Thr Ser Arg Gln Gln Ser Arg Thr Arg Ser 
                165                 170                 175     


Asp Ser Asn Gln Ser Ser Ser Asp Leu Val Ala Ala Val Thr Leu Ala 
            180                 185                 190         


Leu Lys Asn Leu Gly Phe Asp Asn Gln Ser Lys Ser Pro Ser Ser Ser 
        195                 200                 205             


Gly Thr Ser Thr Pro Lys Lys Pro Asn Lys Pro Leu Ser Gln Pro Arg 
    210                 215                 220                 


Ala Asp Lys Pro Ser Gln Leu Lys Lys Pro Arg Trp Lys Arg Val Pro 
225                 230                 235                 240 


Thr Arg Glu Glu Asn Val Ile Gln Cys Phe Gly Pro Arg Asp Phe Asn 
                245                 250                 255     


His Asn Met Gly Asp Ser Asp Leu Val Gln Asn Gly Val Asp Ala Lys 
            260                 265                 270         


Gly Phe Pro Gln Leu Ala Glu Leu Ile Pro Asn Gln Ala Ala Leu Phe 
        275                 280                 285             


Phe Asp Ser Glu Val Ser Thr Asp Glu Val Gly Asp Asn Val Gln Ile 
    290                 295                 300                 


Thr Tyr Thr Tyr Lys Met Leu Val Ala Lys Asp Asn Lys Asn Leu Pro 
305                 310                 315                 320 


Lys Phe Ile Glu Gln Ile Ser Ala Phe Thr Lys Pro Ser Ser Ile Lys 
                325                 330                 335     


Glu Met Gln Ser Gln Ser Ser His Val Ala Gln Asn Thr Val Leu Asn 
            340                 345                 350         


Ala Ser Ile Pro Glu Ser Lys Pro Leu Ala Asp Asp Asp Ser Ala Ile 
        355                 360                 365             


Ile Glu Ile Val Asn Glu Val Leu His 
    370                 375         


<210>  7
<211>  1170
<212>  DNA
<213>  coronavirus

<400>  7
atggctacag tcaaatgggc tgatgcatct gaaccacaac gtggtcgtca gggtagaata     60

ccttattctc tttatagccc tttgcttgtt gatagtgaac aaccttggaa ggtgatacct    120

cgtaatttgg tacccatcaa caagaaagac aaaaataagc ttataggcta ttggaatgtt    180

caaaaacgtt tcagaactag aaagggcaaa cgggtggatt tgtcacccaa gctgcatttt    240

tattatcttg gcacaggacc ccataaagat gcaaaattta gagagcgtgt tgaaggtgtc    300

gtctgggttg ctgttgatgg tgctaaaact gaacctacag gttacggtgt taggcgcaag    360

aattcagaac cagagatacc acacttcaat caaaagctcc caaatggtgt tactgttgtt    420

gaagaacctg actcccgtgc tccttcccgg tctcagtcga ggtcgcagag tcgcggtcgt    480

ggtgaatcca aacctcaatc tcggaatcct tcaagtgaca gaaaccataa cagtcaggat    540

gacatcatga aggcagttgc tgcggctctt aaatctttag gttttgacaa gcctcaggaa    600

aaagataaaa agtcagcgaa aacgggtact cctaagcctt ctcgtaatca gagtcctgct    660

tcttctcaaa cttctgccaa gagtcttgct cgttctcaga gttctgaaac aaaagaacaa    720

aagcatgaaa tgcaaaagcc acggtggaaa agacagccta atgatgatgt gacatctaat    780

gtcacacaat gttttggccc cagagacctt gaccacaact ttggaagtgc aggtgttgtg    840

gccaatggtg ttaaagctaa aggctatcca caatttgctg agcttgtgcc gtcaacagct    900

gctatgctgt ttgatagtca cattgtttcc aaagagtcag gcaacactgt ggtcttgact    960

ttcactacta gagtgactgt gcccaaagac catccacact tgggtaagtt tcttgaggag   1020

ttaaatgcat tcactagaga aatgcaacaa catcctcttc ttaaccctag tgcactagaa   1080

ttcaacccat ctcaaacttc acctgcaact gctgaaccag tgcgtgatga agtttctatt   1140

gaaactgaca taattgatga agtaaactaa                                    1170


<210>  8
<211>  389
<212>  PRT
<213>  coronavirus

<400>  8

Met Ala Thr Val Lys Trp Ala Asp Ala Ser Glu Pro Gln Arg Gly Arg 
1               5                   10                  15      


Gln Gly Arg Ile Pro Tyr Ser Leu Tyr Ser Pro Leu Leu Val Asp Ser 
            20                  25                  30          


Glu Gln Pro Trp Lys Val Ile Pro Arg Asn Leu Val Pro Ile Asn Lys 
        35                  40                  45              


Lys Asp Lys Asn Lys Leu Ile Gly Tyr Trp Asn Val Gln Lys Arg Phe 
    50                  55                  60                  


Arg Thr Arg Lys Gly Lys Arg Val Asp Leu Ser Pro Lys Leu His Phe 
65                  70                  75                  80  


Tyr Tyr Leu Gly Thr Gly Pro His Lys Asp Ala Lys Phe Arg Glu Arg 
                85                  90                  95      


Val Glu Gly Val Val Trp Val Ala Val Asp Gly Ala Lys Thr Glu Pro 
            100                 105                 110         


Thr Gly Tyr Gly Val Arg Arg Lys Asn Ser Glu Pro Glu Ile Pro His 
        115                 120                 125             


Phe Asn Gln Lys Leu Pro Asn Gly Val Thr Val Val Glu Glu Pro Asp 
    130                 135                 140                 


Ser Arg Ala Pro Ser Arg Ser Gln Ser Arg Ser Gln Ser Arg Gly Arg 
145                 150                 155                 160 


Gly Glu Ser Lys Pro Gln Ser Arg Asn Pro Ser Ser Asp Arg Asn His 
                165                 170                 175     


Asn Ser Gln Asp Asp Ile Met Lys Ala Val Ala Ala Ala Leu Lys Ser 
            180                 185                 190         


Leu Gly Phe Asp Lys Pro Gln Glu Lys Asp Lys Lys Ser Ala Lys Thr 
        195                 200                 205             


Gly Thr Pro Lys Pro Ser Arg Asn Gln Ser Pro Ala Ser Ser Gln Thr 
    210                 215                 220                 


Ser Ala Lys Ser Leu Ala Arg Ser Gln Ser Ser Glu Thr Lys Glu Gln 
225                 230                 235                 240 


Lys His Glu Met Gln Lys Pro Arg Trp Lys Arg Gln Pro Asn Asp Asp 
                245                 250                 255     


Val Thr Ser Asn Val Thr Gln Cys Phe Gly Pro Arg Asp Leu Asp His 
            260                 265                 270         


Asn Phe Gly Ser Ala Gly Val Val Ala Asn Gly Val Lys Ala Lys Gly 
        275                 280                 285             


Tyr Pro Gln Phe Ala Glu Leu Val Pro Ser Thr Ala Ala Met Leu Phe 
    290                 295                 300                 


Asp Ser His Ile Val Ser Lys Glu Ser Gly Asn Thr Val Val Leu Thr 
305                 310                 315                 320 


Phe Thr Thr Arg Val Thr Val Ser Lys Asp His Pro His Leu Gly Lys 
                325                 330                 335     


Phe Leu Glu Glu Leu Asn Ala Phe Thr Arg Glu Met Gln Gln His Pro 
            340                 345                 350         


Leu Leu Asn Pro Ser Ala Leu Glu Phe Asn Pro Ser Gln Thr Ser Pro 
        355                 360                 365             


Ala Thr Ala Glu Pro Val Arg Asp Glu Val Ser Ile Glu Thr Asp Ile 
    370                 375                 380                 


Ile Asp Glu Val Asn 
385                 


<210>  9
<211>  1170
<212>  DNA
<213>  coronavirus

<400>  9
atggctacag tcaaatgggc tgatgcatct gaaccacaac gtggtcgtca gggtagaata     60

ccttattctc tttatagccc tttgcttgtt gatagtgaac aaccttggaa ggtgatacct    120

cgtaatttgg tacccatcaa caagaaagac aaaaataagc ttataggcta ttggaatgtt    180

caaaaacgtt tcagaactag aaagggcaaa cgggtggatt tgtcacccaa gctgcatttt    240

tattatcttg gcacaggacc ccataaagat gcaaaattta gagagcgtgt tgaaggtgtc    300

gtctgggttg ctgttgatgg tgctaaaact gaacctacag gttacggtgt taggcgcaag    360

aattcagaac cagagatacc acacttcaat caaaagctcc caaatggtgt tactgttgtt    420

gaagaacctg actcccgtgc tccttcccgg tctcagtcga ggtcgcagag tcgcggtcgt    480

ggtgaatcca aacctcaatc tcggaatcct tcaagtgaca gaaaccataa cagtcaggat    540

gacatcatga aggcagttgc tgcggctctt aaatctttag gttttgacaa gcctcaggaa    600

aaagataaaa agtcagcgaa aacgggtact cctaagcctt ctcgtaatca gagtcctgct    660

tcttctcaaa cttctgccaa gagtcttgct cgttctcaga gttctgaaac aaaagaacaa    720

aagcatgaaa tgcaaaagcc acggtggaaa agacagccta atgatgatgt gacatctaat    780

gtcacacaat gttttggccc cagagacctt gaccacaact ttggaagtgc aggtgttgtg    840

gccaatggtg ttaaagctaa aggctatcca caatttgctg agcttgtgcc gtcaacagct    900

gctatgctgt ttgatagtca cattgtttcc aaagagtcag gcaacactgt ggtcttgact    960

ttcactacta gagtgactgt gcccaaagac catccacact tgggtaagtt tcttgaggag   1020

ttaaatgcat tcactagaga aatgcaacaa catcctcttc ttaaccctag tgcactagaa   1080

ttcaacccat ctcaaacttc acctgcaact gctgaaccag tgcgtgatga agtttctatt   1140

gaaactgaca taattgatga agtaaactaa                                    1170


<210>  10
<211>  389
<212>  PRT
<213>  coronavirus

<400>  10

Met Ala Thr Val Lys Trp Ala Asp Ala Ser Glu Pro Gln Arg Gly Arg 
1               5                   10                  15      


Gln Gly Arg Ile Pro Tyr Ser Leu Tyr Ser Pro Leu Leu Val Asp Ser 
            20                  25                  30          


Glu Gln Pro Trp Lys Val Ile Pro Arg Asn Leu Val Pro Ile Asn Lys 
        35                  40                  45              


Lys Asp Lys Asn Lys Leu Ile Gly Tyr Trp Asn Val Gln Lys Arg Phe 
    50                  55                  60                  


Arg Thr Arg Lys Gly Lys Arg Val Asp Leu Ser Pro Lys Leu His Phe 
65                  70                  75                  80  


Tyr Tyr Leu Gly Thr Gly Pro His Lys Asp Ala Lys Phe Arg Glu Arg 
                85                  90                  95      


Val Glu Gly Val Val Trp Val Ala Val Asp Gly Ala Lys Thr Glu Pro 
            100                 105                 110         


Thr Gly Tyr Gly Val Arg Arg Lys Asn Ser Glu Pro Glu Ile Pro His 
        115                 120                 125             


Phe Asn Gln Lys Leu Pro Asn Gly Val Thr Val Val Glu Glu Pro Asp 
    130                 135                 140                 


Ser Arg Ala Pro Ser Arg Ser Gln Ser Arg Ser Gln Ser Arg Gly Arg 
145                 150                 155                 160 


Gly Glu Ser Lys Pro Gln Ser Arg Asn Pro Ser Ser Asp Arg Asn His 
                165                 170                 175     


Asn Ser Gln Asp Asp Ile Met Lys Ala Val Ala Ala Ala Leu Lys Ser 
            180                 185                 190         


Leu Gly Phe Asp Lys Pro Gln Glu Lys Asp Lys Lys Ser Ala Lys Thr 
        195                 200                 205             


Gly Thr Pro Lys Pro Ser Arg Asn Gln Ser Pro Ala Ser Ser Gln Thr 
    210                 215                 220                 


Ser Ala Lys Ser Leu Ala Arg Ser Gln Ser Ser Glu Thr Lys Glu Gln 
225                 230                 235                 240 


Lys His Glu Met Gln Lys Pro Arg Trp Lys Arg Gln Pro Asn Asp Asp 
                245                 250                 255     


Val Thr Ser Asn Val Thr Gln Cys Phe Gly Pro Arg Asp Leu Asp His 
            260                 265                 270         


Asn Phe Gly Ser Ala Gly Val Val Ala Asn Gly Val Lys Ala Lys Gly 
        275                 280                 285             


Tyr Pro Gln Phe Ala Glu Leu Val Pro Ser Thr Ala Ala Met Leu Phe 
    290                 295                 300                 


Asp Ser His Ile Val Ser Lys Glu Ser Gly Asn Thr Val Val Leu Thr 
305                 310                 315                 320 


Phe Thr Thr Arg Val Thr Val Pro Lys Asp His Pro His Leu Gly Lys 
                325                 330                 335     


Phe Leu Glu Glu Leu Asn Ala Phe Thr Arg Glu Met Gln Gln His Pro 
            340                 345                 350         


Leu Leu Asn Pro Ser Ala Leu Glu Phe Asn Pro Ser Gln Thr Ser Pro 
        355                 360                 365             


Ala Thr Ala Glu Pro Val Arg Asp Glu Val Ser Ile Glu Thr Asp Ile 
    370                 375                 380                 


Ile Asp Glu Val Asn 
385                 


<210>  11
<211>  1260
<212>  DNA
<213>  coronavirus

<400>  11
atgtctgata atggacccca aaatcagcga aatgcacccc gcattacgtt tggtggaccc     60

tcagattcaa ctggcagtaa ccagaatgga gaacgcagtg gggcgcgatc aaaacaacgt    120

cggccccaag gtttacccaa taatactgcg tcttggttca ccgctctcac tcaacatggc    180

aaggaagacc ttaaattccc tcgaggacaa ggcgttccaa ttaacaccaa tagcagtcca    240

gatgaccaaa ttggctacta ccgaagagct accagacgaa ttcgtggtgg tgacggtaaa    300

atgaaagatc tcagtccaag atggtatttc tactacctag gaactgggcc agaagctgga    360

cttccctatg gtgctaacaa agacggcatc atatgggttg caactgaggg agccttgaat    420

acaccaaaag atcacattgg cacccgcaat cctgctaaca atgctgcaat cgtgctacaa    480

cttcctcaag gaacaacatt gccaaaaggc ttctacgcag aagggagcag aggcggcagt    540

caagcctctt ctcgttcctc atcacgtagt cgcaacagtt caagaaattc aactccaggc    600

agcagtaggg gaacttctcc tgctagaatg gctggcaatg gcggtgatgc tgctcttgct    660

ttgctgctgc ttgacagatt gaaccagctt gagagcaaaa tgtctggtaa aggccaacaa    720

caacaaggcc aaactgtcac taagaaatct gctgctgagg cttctaagaa gcctcggcaa    780

aaacgtactg ccactaaagc atacaatgta acacaagctt tcggcagacg tggtccagaa    840

caaacccaag gaaattttgg ggaccaggaa ctaatcagac aaggaactga ttacaaacat    900

tggccgcaaa ttgcacaatt tgcccccagc gcttcagcgt tcttcggaat gtcgcgcatt    960

ggcatggaag tcacaccttc gggaacgtgg ttgacctaca caggtgccat caaattggat   1020

gacaaagatc caaatttcaa agatcaagtc attttgctga ataagcatat tgacgcatac   1080

aaaacattcc caccaacaga gcctaaaaag gacaaaaaga agaaggctga tgaaactcaa   1140

gccttaccgc agagacagaa gaaacagcaa actgtgactc ttcttcctgc tgcagatttg   1200

gatgatttct ccaaacaatt gcaacaatcc atgagcagtg ctgactcaac tcaggcctaa   1260


<210>  12
<211>  419
<212>  PRT
<213>  coronavirus

<400>  12

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
65                  70                  75                  80  


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
                85                  90                  95      


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
            100                 105                 110         


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
        115                 120                 125             


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
    130                 135                 140                 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
145                 150                 155                 160 


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
                165                 170                 175     


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
            180                 185                 190         


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
        195                 200                 205             


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
    210                 215                 220                 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
225                 230                 235                 240 


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
                245                 250                 255     


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
            260                 265                 270         


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
        275                 280                 285             


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
    290                 295                 300                 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
305                 310                 315                 320 


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
                325                 330                 335     


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
            340                 345                 350         


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
        355                 360                 365             


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
    370                 375                 380                 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
385                 390                 395                 400 


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
                405                 410                 415     


Thr Gln Ala 
            


<210>  13
<211>  4062
<212>  DNA
<213>  coronavirus

<400>  13
atgtttttga tacttttaat ttccttacca acggcttttg ctgttatagg agatttaaag     60

tgtacttcag ataatattaa tgataaagac accggtcctc ctcctataag tactgatact    120

gttgatgtta ctaatggttt gggtacttat tatgttttag atcgtgtgta tttaaatact    180

acgttgtttc ttaatggtta ttaccctact tcaggttcca catatcgtaa tatggcactg    240

aagggaagtg tactattgag cagactatgg tttaaaccac catttctttc tgattttatt    300

aatggtattt ttgctaaggt caaaaatacc aaggttatta aagatcgtgt aatgtatagt    360

gagttccctg ctataactat aggtagtact tttgtaaata catcctatag tgtggtagta    420

caaccacgta caatcaattc aacacaggat ggtgataata aattacaagg tcttttagag    480

gtctctgttt gccagtataa tatgtgcgag tacccacaaa cgatttgtca tcctaacctg    540

ggtaatcatc gcaaagaact atggcatttg gatacaggtg ttgtttcctg tttatataag    600

cgtaatttca catatgatgt gaatgctgat tatttgtatt ttcattttta tcaagaaggt    660

ggtacttttt atgcatattt tacagacact ggtgttgtta ctaagttttt gtttaatgtt    720

tatttaggca tggcgctttc acactattat gtcatgcctc tgacttgtaa tagtaagctt    780

actttagaat attgggttac acctctcact tctagacaat atttactcgc tttcaatcaa    840

gatggtatta tttttaatgc tgttgattgt atgagtgatt ttatgagtga gattaagtgt    900

aaaacacaat ctatagcacc acctactggt gtttatgaat taaacggtta cactgttcag    960

ccaatcgcag atgtttaccg acgtaaacct aatcttccca attgcaatat agaagcttgg   1020

cttaatgata agtcggtgcc ctctccatta aattgggaac gtaagacatt ttcaaattgt   1080

aattttaata tgagcagcct gatgtctttt attcaggcag actcatttac ttgtaataat   1140

attgatgctg ctaagatata tggtatgtgt ttttccagca taactataga taagtttgct   1200

atacccaatg gcaggaaggt tgacctacaa ttgggtaatt tgggctattt gcagtcattt   1260

aactatagaa ttgatactac tgcaacaagt tgtcagttgt attataattt acctgctgct   1320

aatgtttctg ttagcaggtt taatccttct acttggaata agagatttgg ttttatagaa   1380

gattctgttt ttaagcctcg acctgcaggt gttcttacta atcatgatgt agtttatgca   1440

caacactgtt tcaaagctcc taaaaatttc tgtccgtgta aattgaatgg ttcgtgtgta   1500

ggtagtggtc ctggtaaaaa taatggtata ggcacttgtc ctgcaggtac taattattta   1560

acttgtgata atttgtgcac tcctgatcct attacattta caggtactta taagtgcccc   1620

caaactaaat ctttagttgg cataggtgag cactgttcgg gtcttgctgt taaaagtgat   1680

tattgtggag gcaattcttg tacttgccga ccacaagcat ttttgggttg gtctgcagac   1740

tcttgtttac aaggagacaa gtgtaatatt tttgctaatt ttattttgca tgatgttaat   1800

agtggtctta cttgttctac tgatttacaa aaagctaaca cagacataat tcttggtgtt   1860

tgtgttaatt atgacctcta tggtatttta ggccaaggca tttttgttga ggttaatgcg   1920

acttattata atagttggca gaacctttta tatgattcta atggtaatct ctacggtttt   1980

agagactaca taacaaacag aacttttatg attcgtagtt gctatagcgg tcgtgtttct   2040

gcggcctttc acgctaactc ttccgaacca gcattgctat ttcggaatat taaatgcaac   2100

tacgttttta ataatagtct tacacgacag ctgcaaccca ttaactattt tgatagttat   2160

cttggttgtg ttgtcaatgc ttataatagt actgctattt ctgttcaaac atgtgatctc   2220

acagtaggta gtggttactg tgtggattac tctaaaaaca gacgaagtcg tggagcgatt   2280

accactggtt atcggtttac taattttgag ccatttactg ttaattcagt aaacgatagt   2340

ttagaacctg taggtggttt gtatgaaatt caaatacctt cagagtttac tataggtaat   2400

atggtggagt ttattcaaac aagctctcct aaagttacta ttgattgtgc tgcatttgtc   2460

tgtggtgatt atgcagcatg taaatcacag ttggttgaat atggtagttt ctgtgataac   2520

attaatgcca tactcacaga agtaaatgaa ctacttgaca ctacacagtt gcaagtagct   2580

aatagtttaa tgaatggtgt tactcttagc actaagctta aagatggcgt taatttcaat   2640

gtagacgaca tcaatttttc ccctgtatta ggttgtctag gcagcgaatg tagtaaagct   2700

tccagtagat ctgctataga ggatttactt tttgataaag taaagttatc tgatgtcggt   2760

tttgttgagg cttataataa ttgtacagga ggtgccgaaa ttagggacct catttgtgtg   2820

caaagttata aaggcatcaa agtgttgcct ccactgctct cagaaaatca gatcagtgga   2880

tacactttgg ctgccacctc tgctagtcta tttcctcctt ggacagcagc agcaggtgta   2940

ccattttatt taaatgttca gtatcgcatt aatgggcttg gtgtcaccat ggatgtgcta   3000

agtcaaaatc aaaagcttat tgctaatgca tttaacaatg ccctttatgc tattcaggaa   3060

gggttcgatg caactaattc tgctttagtt aaaattcaag ctgttgttaa tgcaaatgct   3120

gaagctctta ataacttatt gcaacaactc tctaatagat ttggtgctat aagtgcttct   3180

ttacaagaaa ttctatctag acttgatgct cttgaagcgg aagctcagat agatagactt   3240

attaatggtc gtcttaccgc tcttaatgct tatgtttctc aacagcttag tgattctaca   3300

ctggtaaaat ttagtgcagc acaagctatg gagaaggtta atgaatgtgt caaaagccaa   3360

tcatctagga taaatttctg tggtaatggt aatcatatta tatcattagt gcagaatgct   3420

ccatatggtt tgtattttat ccactttagt tatgtcccta ctaagtatgt cacagcgagg   3480

gttagtcctg gtctgtgcat tgctggtgat agaggtatag ctcctaagag tggttatttt   3540

gttaatgtaa ataatacttg gatgtacact ggtagtggtt actactaccc tgaacctata   3600

actgaaaata atgttgttgt tatgagtacc tgcgctgtta attatactaa agcgccgtat   3660

gtaatgctga acacttcaat acccaacctt cctgatttta aggaagagtt ggatcaatgg   3720

tttaaaaatc aaacatcagt ggcaccagat ttgtcacttg attatataaa tgttacattc   3780

ttggacctac aagttgaaat gaataggtta caggaggcaa taaaagtctt aaatcagagc   3840

tacatcaatc tcaaggacat tggtacatat gaatattatg taaaatggcc ttggtatgta   3900

tggcttttaa tctgccttgc tggtgtagct atgcttgttt tactattctt catatgctgt   3960

tgtacaggat gtgggactag ttgttttaag aaatgtggtg gttgttgtga tgattatact   4020

ggataccagg agttagtaat caaaacttca catgacgact aa                      4062


<210>  14
<211>  1353
<212>  PRT
<213>  coronavirus

<400>  14

Met Phe Leu Ile Leu Leu Ile Ser Leu Pro Thr Ala Phe Ala Val Ile 
1               5                   10                  15      


Gly Asp Leu Lys Cys Thr Ser Asp Asn Ile Asn Asp Lys Asp Thr Gly 
            20                  25                  30          


Pro Pro Pro Ile Ser Thr Asp Thr Val Asp Val Thr Asn Gly Leu Gly 
        35                  40                  45              


Thr Tyr Tyr Val Leu Asp Arg Val Tyr Leu Asn Thr Thr Leu Phe Leu 
    50                  55                  60                  


Asn Gly Tyr Tyr Pro Thr Ser Gly Ser Thr Tyr Arg Asn Met Ala Leu 
65                  70                  75                  80  


Lys Gly Ser Val Leu Leu Ser Arg Leu Trp Phe Lys Pro Pro Phe Leu 
                85                  90                  95      


Ser Asp Phe Ile Asn Gly Ile Phe Ala Lys Val Lys Asn Thr Lys Val 
            100                 105                 110         


Ile Lys Asp Arg Val Met Tyr Ser Glu Phe Pro Ala Ile Thr Ile Gly 
        115                 120                 125             


Ser Thr Phe Val Asn Thr Ser Tyr Ser Val Val Val Gln Pro Arg Thr 
    130                 135                 140                 


Ile Asn Ser Thr Gln Asp Gly Asp Asn Lys Leu Gln Gly Leu Leu Glu 
145                 150                 155                 160 


Val Ser Val Cys Gln Tyr Asn Met Cys Glu Tyr Pro Gln Thr Ile Cys 
                165                 170                 175     


His Pro Asn Leu Gly Asn His Arg Lys Glu Leu Trp His Leu Asp Thr 
            180                 185                 190         


Gly Val Val Ser Cys Leu Tyr Lys Arg Asn Phe Thr Tyr Asp Val Asn 
        195                 200                 205             


Ala Asp Tyr Leu Tyr Phe His Phe Tyr Gln Glu Gly Gly Thr Phe Tyr 
    210                 215                 220                 


Ala Tyr Phe Thr Asp Thr Gly Val Val Thr Lys Phe Leu Phe Asn Val 
225                 230                 235                 240 


Tyr Leu Gly Met Ala Leu Ser His Tyr Tyr Val Met Pro Leu Thr Cys 
                245                 250                 255     


Asn Ser Lys Leu Thr Leu Glu Tyr Trp Val Thr Pro Leu Thr Ser Arg 
            260                 265                 270         


Gln Tyr Leu Leu Ala Phe Asn Gln Asp Gly Ile Ile Phe Asn Ala Val 
        275                 280                 285             


Asp Cys Met Ser Asp Phe Met Ser Glu Ile Lys Cys Lys Thr Gln Ser 
    290                 295                 300                 


Ile Ala Pro Pro Thr Gly Val Tyr Glu Leu Asn Gly Tyr Thr Val Gln 
305                 310                 315                 320 


Pro Ile Ala Asp Val Tyr Arg Arg Lys Pro Asn Leu Pro Asn Cys Asn 
                325                 330                 335     


Ile Glu Ala Trp Leu Asn Asp Lys Ser Val Pro Ser Pro Leu Asn Trp 
            340                 345                 350         


Glu Arg Lys Thr Phe Ser Asn Cys Asn Phe Asn Met Ser Ser Leu Met 
        355                 360                 365             


Ser Phe Ile Gln Ala Asp Ser Phe Thr Cys Asn Asn Ile Asp Ala Ala 
    370                 375                 380                 


Lys Ile Tyr Gly Met Cys Phe Ser Ser Ile Thr Ile Asp Lys Phe Ala 
385                 390                 395                 400 


Ile Pro Asn Gly Arg Lys Val Asp Leu Gln Leu Gly Asn Leu Gly Tyr 
                405                 410                 415     


Leu Gln Ser Phe Asn Tyr Arg Ile Asp Thr Thr Ala Thr Ser Cys Gln 
            420                 425                 430         


Leu Tyr Tyr Asn Leu Pro Ala Ala Asn Val Ser Val Ser Arg Phe Asn 
        435                 440                 445             


Pro Ser Thr Trp Asn Lys Arg Phe Gly Phe Ile Glu Asp Ser Val Phe 
    450                 455                 460                 


Lys Pro Arg Pro Ala Gly Val Leu Thr Asn His Asp Val Val Tyr Ala 
465                 470                 475                 480 


Gln His Cys Phe Lys Ala Pro Lys Asn Phe Cys Pro Cys Lys Leu Asn 
                485                 490                 495     


Gly Ser Cys Val Gly Ser Gly Pro Gly Lys Asn Asn Gly Ile Gly Thr 
            500                 505                 510         


Cys Pro Ala Gly Thr Asn Tyr Leu Thr Cys Asp Asn Leu Cys Thr Pro 
        515                 520                 525             


Asp Pro Ile Thr Phe Thr Gly Thr Tyr Lys Cys Pro Gln Thr Lys Ser 
    530                 535                 540                 


Leu Val Gly Ile Gly Glu His Cys Ser Gly Leu Ala Val Lys Ser Asp 
545                 550                 555                 560 


Tyr Cys Gly Gly Asn Ser Cys Thr Cys Arg Pro Gln Ala Phe Leu Gly 
                565                 570                 575     


Trp Ser Ala Asp Ser Cys Leu Gln Gly Asp Lys Cys Asn Ile Phe Ala 
            580                 585                 590         


Asn Phe Ile Leu His Asp Val Asn Ser Gly Leu Thr Cys Ser Thr Asp 
        595                 600                 605             


Leu Gln Lys Ala Asn Thr Asp Ile Ile Leu Gly Val Cys Val Asn Tyr 
    610                 615                 620                 


Asp Leu Tyr Gly Ile Leu Gly Gln Gly Ile Phe Val Glu Val Asn Ala 
625                 630                 635                 640 


Thr Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
                645                 650                 655     


Leu Tyr Gly Phe Arg Asp Tyr Ile Thr Asn Arg Thr Phe Met Ile Arg 
            660                 665                 670         


Ser Cys Tyr Ser Gly Arg Val Ser Ala Ala Phe His Ala Asn Ser Ser 
        675                 680                 685             


Glu Pro Ala Leu Leu Phe Arg Asn Ile Lys Cys Asn Tyr Val Phe Asn 
    690                 695                 700                 


Asn Ser Leu Thr Arg Gln Leu Gln Pro Ile Asn Tyr Phe Asp Ser Tyr 
705                 710                 715                 720 


Leu Gly Cys Val Val Asn Ala Tyr Asn Ser Thr Ala Ile Ser Val Gln 
                725                 730                 735     


Thr Cys Asp Leu Thr Val Gly Ser Gly Tyr Cys Val Asp Tyr Ser Lys 
            740                 745                 750         


Asn Arg Arg Ser Arg Gly Ala Ile Thr Thr Gly Tyr Arg Phe Thr Asn 
        755                 760                 765             


Phe Glu Pro Phe Thr Val Asn Ser Val Asn Asp Ser Leu Glu Pro Val 
    770                 775                 780                 


Gly Gly Leu Tyr Glu Ile Gln Ile Pro Ser Glu Phe Thr Ile Gly Asn 
785                 790                 795                 800 


Met Val Glu Phe Ile Gln Thr Ser Ser Pro Lys Val Thr Ile Asp Cys 
                805                 810                 815     


Ala Ala Phe Val Cys Gly Asp Tyr Ala Ala Cys Lys Ser Gln Leu Val 
            820                 825                 830         


Glu Tyr Gly Ser Phe Cys Asp Asn Ile Asn Ala Ile Leu Thr Glu Val 
        835                 840                 845             


Asn Glu Leu Leu Asp Thr Thr Gln Leu Gln Val Ala Asn Ser Leu Met 
    850                 855                 860                 


Asn Gly Val Thr Leu Ser Thr Lys Leu Lys Asp Gly Val Asn Phe Asn 
865                 870                 875                 880 


Val Asp Asp Ile Asn Phe Ser Pro Val Leu Gly Cys Leu Gly Ser Glu 
                885                 890                 895     


Cys Ser Lys Ala Ser Ser Arg Ser Ala Ile Glu Asp Leu Leu Phe Asp 
            900                 905                 910         


Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn Cys 
        915                 920                 925             


Thr Gly Gly Ala Glu Ile Arg Asp Leu Ile Cys Val Gln Ser Tyr Lys 
    930                 935                 940                 


Gly Ile Lys Val Leu Pro Pro Leu Leu Ser Glu Asn Gln Ile Ser Gly 
945                 950                 955                 960 


Tyr Thr Leu Ala Ala Thr Ser Ala Ser Leu Phe Pro Pro Trp Thr Ala 
                965                 970                 975     


Ala Ala Gly Val Pro Phe Tyr Leu Asn Val Gln Tyr Arg Ile Asn Gly 
            980                 985                 990         


Leu Gly Val Thr Met Asp Val Leu  Ser Gln Asn Gln Lys  Leu Ile Ala 
        995                 1000                 1005             


Asn Ala  Phe Asn Asn Ala Leu  Tyr Ala Ile Gln Glu  Gly Phe Asp 
    1010                 1015                 1020             


Ala Thr  Asn Ser Ala Leu Val  Lys Ile Gln Ala Val  Val Asn Ala 
    1025                 1030                 1035             


Asn Ala  Glu Ala Leu Asn Asn  Leu Leu Gln Gln Leu  Ser Asn Arg 
    1040                 1045                 1050             


Phe Gly  Ala Ile Ser Ala Ser  Leu Gln Glu Ile Leu  Ser Arg Leu 
    1055                 1060                 1065             


Asp Ala  Leu Glu Ala Glu Ala  Gln Ile Asp Arg Leu  Ile Asn Gly 
    1070                 1075                 1080             


Arg Leu  Thr Ala Leu Asn Ala  Tyr Val Ser Gln Gln  Leu Ser Asp 
    1085                 1090                 1095             


Ser Thr  Leu Val Lys Phe Ser  Ala Ala Gln Ala Met  Glu Lys Val 
    1100                 1105                 1110             


Asn Glu  Cys Val Lys Ser Gln  Ser Ser Arg Ile Asn  Phe Cys Gly 
    1115                 1120                 1125             


Asn Gly  Asn His Ile Ile Ser  Leu Val Gln Asn Ala  Pro Tyr Gly 
    1130                 1135                 1140             


Leu Tyr  Phe Ile His Phe Ser  Tyr Val Pro Thr Lys  Tyr Val Thr 
    1145                 1150                 1155             


Ala Arg  Val Ser Pro Gly Leu  Cys Ile Ala Gly Asp  Arg Gly Ile 
    1160                 1165                 1170             


Ala Pro  Lys Ser Gly Tyr Phe  Val Asn Val Asn Asn  Thr Trp Met 
    1175                 1180                 1185             


Tyr Thr  Gly Ser Gly Tyr Tyr  Tyr Pro Glu Pro Ile  Thr Glu Asn 
    1190                 1195                 1200             


Asn Val  Val Val Met Ser Thr  Cys Ala Val Asn Tyr  Thr Lys Ala 
    1205                 1210                 1215             


Pro Tyr  Val Met Leu Asn Thr  Ser Ile Pro Asn Leu  Pro Asp Phe 
    1220                 1225                 1230             


Lys Glu  Glu Leu Asp Gln Trp  Phe Lys Asn Gln Thr  Ser Val Ala 
    1235                 1240                 1245             


Pro Asp  Leu Ser Leu Asp Tyr  Ile Asn Val Thr Phe  Leu Asp Leu 
    1250                 1255                 1260             


Gln Val  Glu Met Asn Arg Leu  Gln Glu Ala Ile Lys  Val Leu Asn 
    1265                 1270                 1275             


Gln Ser  Tyr Ile Asn Leu Lys  Asp Ile Gly Thr Tyr  Glu Tyr Tyr 
    1280                 1285                 1290             


Val Lys  Trp Pro Trp Tyr Val  Trp Leu Leu Ile Cys  Leu Ala Gly 
    1295                 1300                 1305             


Val Ala  Met Leu Val Leu Leu  Phe Phe Ile Cys Cys  Cys Thr Gly 
    1310                 1315                 1320             


Cys Gly  Thr Ser Cys Phe Lys  Lys Cys Gly Gly Cys  Cys Asp Asp 
    1325                 1330                 1335             


Tyr Thr  Gly Tyr Gln Glu Leu  Val Ile Lys Thr Ser  His Asp Asp 
    1340                 1345                 1350             


<210>  15
<211>  4071
<212>  DNA
<213>  coronavirus

<400>  15
atgttattaa ttatttttat tttgcctaca acattagctg ttataggtga ttttaattgt     60

actaattttg ctattaatga tttaaacacc acagttcctc gcataagtga gtatgttgtg    120

gatgtttctt atggtttggg tacatattat atacttgatc gtgtttattt aaatactact    180

atattattta ctggttattt ccctaaatct ggtgccaatt ttagggatct atctttaaaa    240

ggtactacat atttgagtac tctttggtat cagaaaccct ttttatctga ttttaataat    300

ggtatttttt ctagagttaa gaatactaag ttgtatgtta ataaaacttt gtatagtgag    360

tttagtacta tagttatagg tagtgttttt attaacaact cttatactat tgttgttcaa    420

cctcataatg gtgttttgga gattacagct tgtcaataca ctatgtgtga gtatcctcat    480

actatttgta aatctaaagg tagttctcgt aatgaatctt ggcattttga taaatctgaa    540

cctttgtgtc tgttcaagaa aaattttact tataatgttt ctacagattg gttgtatttt    600

catttttatc aagaacgtgg cactttttat gcttattatg ctgattctgg catgcctact    660

acttttttat ttagtttgta tcttggtact cttttatctc attattatgt tttgcctttg    720

acttgtaatg ctatatcttc taatactgat aatgagactt tacaatattg ggtcacacct    780

ttgtctaaac gccaatatct tcttaaattt gacaaccgtg gtgttattac taatgctgtt    840

gattgttcta gtagtttctt tagcgagatt caatgtaaaa ctaaatcttt attacctaat    900

actggtgttt atgacttatc tggttttact gttaagcctg ttgcaactgt acatcgtcgt    960

attcctgatt tacctgattg tgacattgat aaatggctta acaattttaa tgtaccctca   1020

cctcttaatt gggaacgtaa aattttttct aattgcaact ttaatttgag tactttgctt   1080

cgtttagttc atactgattc tttttcttgt aataattttg atgaatctaa gatatatggt   1140

agttgtttta agagtattgt tttagataaa tttgccatac ccaactccag acgatctgat   1200

ttgcagttgg gcagttctgg ttttctgcaa tcttctaatt ataaaattga cactacttct   1260

agttcttgtc aattgtatta tagtttgcct gcaattaatg ttactattaa taattataat   1320

ccttcttctt ggaatagaag gtatggtttt aataatttta atttgagctc tcatagtgtt   1380

gtttactcac gttattgttt ttctgttaat aatacttttt gtccttgtgc taaaccttct   1440

tttgcttcaa gttgcaagag tcataaacca ccttctgctt cctgtcctat tggtactaat   1500

tatcgttctt gtgagagtac tactgtactc gaccacactg actggtgtag gtgttcttgt   1560

ttacctgatc ctataactgc ttatgaccct aggtcttgtt ctcaaaaaaa gtctctggtt   1620

ggtgttggtg aacattgtgc agggttcggt gttgatgaag aaaagtgtgg tgtattggat   1680

ggatcatata atgtttcttg tctttgtagt actgatgcct ttctaggttg gtcttatgac   1740

acttgcgtca gtaacaaccg ttgtaatatt ttttctaatt ttattttaaa tggtatcaat   1800

agtggtacca cttgttctaa tgatttattg cagcctaata ctgaagtttt tactgatgtt   1860

tgtgttgatt acgaccttta tggtattaca ggacaaggta tttttaaaga agtttctgct   1920

gtttattata atagttggca aaatcttttg tatgattcta atggcaacat tattggtttt   1980

aaagattttg ttactaataa aacatataat attttccctt gttatgcagg aagagtttct   2040

gctgcttttc atcaaaatgc ttcctctttg gctttacttt atcgtaattt aaaatgtagc   2100

tatgttttga ataatatttc tttaactact cagccatatt ttgatagtta tcttggttgc   2160

gtttttaatg ctgataattt aactgattat tctgtttctt cttgtgctct tcgcatgggt   2220

agtggttttt gtgttgatta taactcacct tcttcttcct cttcgcgtcg taaacgtaga   2280

agtatttctg cttcttatcg ttttgttact tttgaaccct ttaatgtcag ttttgttaat   2340

gacagtattg agtctgtggg tggtctttat gagatcaaaa ttcccactaa ctttactata   2400

gttggtcaag aggaatttat tcaaactaat tctcctaaag ttactattga ttgttcttta   2460

tttgtctgtt ctaattatgc agcttgccat gacttattgt cagagtatgg cactttttgt   2520

gataatatta atagtatttt agatgaagtt aatggtttac ttgatactac tcaattgcat   2580

gtagctgata ctcttatgca aggtgtcaca cttagctcca atcttaatac taatttgcat   2640

tttgatgttg ataatattaa ttttaaatcc ctagttggat gtttaggtcc acactgcggt   2700

tcttcttctc gttctttttt tgaagattta ttgtttgaca aagttaaact ttcagatgtt   2760

ggttttgttg aagcttataa caattgtact ggtggtagtg aaattagaga tcttctttgt   2820

gtacaatcct ttaatggtat taaagttttg cctcctattt tgtctgaatc tcaaatttct   2880

ggttacacca cagccgctac tgttgctgct atgtttccac catggtcagc agcagctggc   2940

ataccatttt ctcttaatgt acaatataga attaatggtt tgggtgttac tatggatgtt   3000

cttaataaaa atcaaaagtt gatagctact gcttttaata atgctcttct ttctattcag   3060

aatggtttta gtgctaccaa ctctgcactt gctaaaatac aaagtgttgt taattctaat   3120

gctcaagcac ttaatagttt gttacagcaa ttatttaata aatttggtgc aattagttct   3180

tctttacaag aaattttatc tcgtctcgat gctttagagg ctcaggttca gattgatagg   3240

cttattaatg gtcgtttaac tgctttaaat gcttatgtct ctcaacagct tagtgatatt   3300

tctcttgtaa aatttggtgc tgctttagct atggagaagg ttaatgagtg tgttaaaagt   3360

caatctcctc gtattaattt ttgtggtaat ggtaatcata ttttgtcatt agttcaaaat   3420

gctccttatg gtttgttgtt tatgcatttt agttataaac ctatttcttt taaaactgtt   3480

ttagtaagtc ctggtttgtg tatatcaggt gatgtaggta ttgcacctaa acaagggtat   3540

tttattaaac ataatgatca ttggatgttc actggtagtt cttactatta tcctgaacca   3600

atttcagata aaaatgttgt ttttatgaat acttgttctg ttaattttac taaagcgcct   3660

cttgtttatt tgaatcattc tgtaccaaaa ttgtctgatt ttgaatctga gttatctcat   3720

tggtttaaaa atcaaacatc cattgcgcct aatttgactt taaatcttca tactattaat   3780

gctacttttt tagatttgta ttatgagatg aatcttattc aagagtctat taagtctttg   3840

aataatagtt atatcaatct taaagatata ggtacatatg aaatgtatgt aaaatggcct   3900

tggtatgttt ggctactaat ttctttttca tttataatat tccttgtatt gctctttttt   3960

atatgttgtt gtactggttg tggttctgca tgttttagta aatgtcataa ttgttgtgat   4020

gagtatggtg gtcatcatga ttttgttatc aaaacatctc atgatgatta g            4071


<210>  16
<211>  1356
<212>  PRT
<213>  coronavirus

<400>  16

Met Leu Leu Ile Ile Phe Ile Leu Pro Thr Thr Leu Ala Val Ile Gly 
1               5                   10                  15      


Asp Phe Asn Cys Thr Asn Phe Ala Ile Asn Asp Leu Asn Thr Thr Val 
            20                  25                  30          


Pro Arg Ile Ser Glu Tyr Val Val Asp Val Ser Tyr Gly Leu Gly Thr 
        35                  40                  45              


Tyr Tyr Ile Leu Asp Arg Val Tyr Leu Asn Thr Thr Ile Leu Phe Thr 
    50                  55                  60                  


Gly Tyr Phe Pro Lys Ser Gly Ala Asn Phe Arg Asp Leu Ser Leu Lys 
65                  70                  75                  80  


Gly Thr Thr Tyr Leu Ser Thr Leu Trp Tyr Gln Lys Pro Phe Leu Ser 
                85                  90                  95      


Asp Phe Asn Asn Gly Ile Phe Ser Arg Val Lys Asn Thr Lys Leu Tyr 
            100                 105                 110         


Val Asn Lys Thr Leu Tyr Ser Glu Phe Ser Thr Ile Val Ile Gly Ser 
        115                 120                 125             


Val Phe Ile Asn Asn Ser Tyr Thr Ile Val Val Gln Pro His Asn Gly 
    130                 135                 140                 


Val Leu Glu Ile Thr Ala Cys Gln Tyr Thr Met Cys Glu Tyr Pro His 
145                 150                 155                 160 


Thr Ile Cys Lys Ser Lys Gly Ser Ser Arg Asn Glu Ser Trp His Phe 
                165                 170                 175     


Asp Lys Ser Glu Pro Leu Cys Leu Phe Lys Lys Asn Phe Thr Tyr Asn 
            180                 185                 190         


Val Ser Thr Asp Trp Leu Tyr Phe His Phe Tyr Gln Glu Arg Gly Thr 
        195                 200                 205             


Phe Tyr Ala Tyr Tyr Ala Asp Ser Gly Met Pro Thr Thr Phe Leu Phe 
    210                 215                 220                 


Ser Leu Tyr Leu Gly Thr Leu Leu Ser His Tyr Tyr Val Leu Pro Leu 
225                 230                 235                 240 


Thr Cys Asn Ala Ile Ser Ser Asn Thr Asp Asn Glu Thr Leu Gln Tyr 
                245                 250                 255     


Trp Val Thr Pro Leu Ser Lys Arg Gln Tyr Leu Leu Lys Phe Asp Asn 
            260                 265                 270         


Arg Gly Val Ile Thr Asn Ala Val Asp Cys Ser Ser Ser Phe Phe Ser 
        275                 280                 285             


Glu Ile Gln Cys Lys Thr Lys Ser Leu Leu Pro Asn Thr Gly Val Tyr 
    290                 295                 300                 


Asp Leu Ser Gly Phe Thr Val Lys Pro Val Ala Thr Val His Arg Arg 
305                 310                 315                 320 


Ile Pro Asp Leu Pro Asp Cys Asp Ile Asp Lys Trp Leu Asn Asn Phe 
                325                 330                 335     


Asn Val Pro Ser Pro Leu Asn Trp Glu Arg Lys Ile Phe Ser Asn Cys 
            340                 345                 350         


Asn Phe Asn Leu Ser Thr Leu Leu Arg Leu Val His Thr Asp Ser Phe 
        355                 360                 365             


Ser Cys Asn Asn Phe Asp Glu Ser Lys Ile Tyr Gly Ser Cys Phe Lys 
    370                 375                 380                 


Ser Ile Val Leu Asp Lys Phe Ala Ile Pro Asn Ser Arg Arg Ser Asp 
385                 390                 395                 400 


Leu Gln Leu Gly Ser Ser Gly Phe Leu Gln Ser Ser Asn Tyr Lys Ile 
                405                 410                 415     


Asp Thr Thr Ser Ser Ser Cys Gln Leu Tyr Tyr Ser Leu Pro Ala Ile 
            420                 425                 430         


Asn Val Thr Ile Asn Asn Tyr Asn Pro Ser Ser Trp Asn Arg Arg Tyr 
        435                 440                 445             


Gly Phe Asn Asn Phe Asn Leu Ser Ser His Ser Val Val Tyr Ser Arg 
    450                 455                 460                 


Tyr Cys Phe Ser Val Asn Asn Thr Phe Cys Pro Cys Ala Lys Pro Ser 
465                 470                 475                 480 


Phe Ala Ser Ser Cys Lys Ser His Lys Pro Pro Ser Ala Ser Cys Pro 
                485                 490                 495     


Ile Gly Thr Asn Tyr Arg Ser Cys Glu Ser Thr Thr Val Leu Asp His 
            500                 505                 510         


Thr Asp Trp Cys Arg Cys Ser Cys Leu Pro Asp Pro Ile Thr Ala Tyr 
        515                 520                 525             


Asp Pro Arg Ser Cys Ser Gln Lys Lys Ser Leu Val Gly Val Gly Glu 
    530                 535                 540                 


His Cys Ala Gly Phe Gly Val Asp Glu Glu Lys Cys Gly Val Leu Asp 
545                 550                 555                 560 


Gly Ser Tyr Asn Val Ser Cys Leu Cys Ser Thr Asp Ala Phe Leu Gly 
                565                 570                 575     


Trp Ser Tyr Asp Thr Cys Val Ser Asn Asn Arg Cys Asn Ile Phe Ser 
            580                 585                 590         


Asn Phe Ile Leu Asn Gly Ile Asn Ser Gly Thr Thr Cys Ser Asn Asp 
        595                 600                 605             


Leu Leu Gln Pro Asn Thr Glu Val Phe Thr Asp Val Cys Val Asp Tyr 
    610                 615                 620                 


Asp Leu Tyr Gly Ile Thr Gly Gln Gly Ile Phe Lys Glu Val Ser Ala 
625                 630                 635                 640 


Val Tyr Tyr Asn Ser Trp Gln Asn Leu Leu Tyr Asp Ser Asn Gly Asn 
                645                 650                 655     


Ile Ile Gly Phe Lys Asp Phe Val Thr Asn Lys Thr Tyr Asn Ile Phe 
            660                 665                 670         


Pro Cys Tyr Ala Gly Arg Val Ser Ala Ala Phe His Gln Asn Ala Ser 
        675                 680                 685             


Ser Leu Ala Leu Leu Tyr Arg Asn Leu Lys Cys Ser Tyr Val Leu Asn 
    690                 695                 700                 


Asn Ile Ser Leu Thr Thr Gln Pro Tyr Phe Asp Ser Tyr Leu Gly Cys 
705                 710                 715                 720 


Val Phe Asn Ala Asp Asn Leu Thr Asp Tyr Ser Val Ser Ser Cys Ala 
                725                 730                 735     


Leu Arg Met Gly Ser Gly Phe Cys Val Asp Tyr Asn Ser Pro Ser Ser 
            740                 745                 750         


Ser Ser Ser Arg Arg Lys Arg Arg Ser Ile Ser Ala Ser Tyr Arg Phe 
        755                 760                 765             


Val Thr Phe Glu Pro Phe Asn Val Ser Phe Val Asn Asp Ser Ile Glu 
    770                 775                 780                 


Ser Val Gly Gly Leu Tyr Glu Ile Lys Ile Pro Thr Asn Phe Thr Ile 
785                 790                 795                 800 


Val Gly Gln Glu Glu Phe Ile Gln Thr Asn Ser Pro Lys Val Thr Ile 
                805                 810                 815     


Asp Cys Ser Leu Phe Val Cys Ser Asn Tyr Ala Ala Cys His Asp Leu 
            820                 825                 830         


Leu Ser Glu Tyr Gly Thr Phe Cys Asp Asn Ile Asn Ser Ile Leu Asp 
        835                 840                 845             


Glu Val Asn Gly Leu Leu Asp Thr Thr Gln Leu His Val Ala Asp Thr 
    850                 855                 860                 


Leu Met Gln Gly Val Thr Leu Ser Ser Asn Leu Asn Thr Asn Leu His 
865                 870                 875                 880 


Phe Asp Val Asp Asn Ile Asn Phe Lys Ser Leu Val Gly Cys Leu Gly 
                885                 890                 895     


Pro His Cys Gly Ser Ser Ser Arg Ser Phe Phe Glu Asp Leu Leu Phe 
            900                 905                 910         


Asp Lys Val Lys Leu Ser Asp Val Gly Phe Val Glu Ala Tyr Asn Asn 
        915                 920                 925             


Cys Thr Gly Gly Ser Glu Ile Arg Asp Leu Leu Cys Val Gln Ser Phe 
    930                 935                 940                 


Asn Gly Ile Lys Val Leu Pro Pro Ile Leu Ser Glu Ser Gln Ile Ser 
945                 950                 955                 960 


Gly Tyr Thr Thr Ala Ala Thr Val Ala Ala Met Phe Pro Pro Trp Ser 
                965                 970                 975     


Ala Ala Ala Gly Ile Pro Phe Ser Leu Asn Val Gln Tyr Arg Ile Asn 
            980                 985                 990         


Gly Leu Gly Val Thr Met Asp Val  Leu Asn Lys Asn Gln  Lys Leu Ile 
        995                 1000                 1005             


Ala Thr  Ala Phe Asn Asn Ala  Leu Leu Ser Ile Gln  Asn Gly Phe 
    1010                 1015                 1020             


Ser Ala  Thr Asn Ser Ala Leu  Ala Lys Ile Gln Ser  Val Val Asn 
    1025                 1030                 1035             


Ser Asn  Ala Gln Ala Leu Asn  Ser Leu Leu Gln Gln  Leu Phe Asn 
    1040                 1045                 1050             


Lys Phe  Gly Ala Ile Ser Ser  Ser Leu Gln Glu Ile  Leu Ser Arg 
    1055                 1060                 1065             


Leu Asp  Ala Leu Glu Ala Gln  Val Gln Ile Asp Arg  Leu Ile Asn 
    1070                 1075                 1080             


Gly Arg  Leu Thr Ala Leu Asn  Ala Tyr Val Ser Gln  Gln Leu Ser 
    1085                 1090                 1095             


Asp Ile  Ser Leu Val Lys Phe  Gly Ala Ala Leu Ala  Met Glu Lys 
    1100                 1105                 1110             


Val Asn  Glu Cys Val Lys Ser  Gln Ser Pro Arg Ile  Asn Phe Cys 
    1115                 1120                 1125             


Gly Asn  Gly Asn His Ile Leu  Ser Leu Val Gln Asn  Ala Pro Tyr 
    1130                 1135                 1140             


Gly Leu  Leu Phe Met His Phe  Ser Tyr Lys Pro Ile  Ser Phe Lys 
    1145                 1150                 1155             


Thr Val  Leu Val Ser Pro Gly  Leu Cys Ile Ser Gly  Asp Val Gly 
    1160                 1165                 1170             


Ile Ala  Pro Lys Gln Gly Tyr  Phe Ile Lys His Asn  Asp His Trp 
    1175                 1180                 1185             


Met Phe  Thr Gly Ser Ser Tyr  Tyr Tyr Pro Glu Pro  Ile Ser Asp 
    1190                 1195                 1200             


Lys Asn  Val Val Phe Met Asn  Thr Cys Ser Val Asn  Phe Thr Lys 
    1205                 1210                 1215             


Ala Pro  Leu Val Tyr Leu Asn  His Ser Val Pro Lys  Leu Ser Asp 
    1220                 1225                 1230             


Phe Glu  Ser Glu Leu Ser His  Trp Phe Lys Asn Gln  Thr Ser Ile 
    1235                 1240                 1245             


Ala Pro  Asn Leu Thr Leu Asn  Leu His Thr Ile Asn  Ala Thr Phe 
    1250                 1255                 1260             


Leu Asp  Leu Tyr Tyr Glu Met  Asn Leu Ile Gln Glu  Ser Ile Lys 
    1265                 1270                 1275             


Ser Leu  Asn Asn Ser Tyr Ile  Asn Leu Lys Asp Ile  Gly Thr Tyr 
    1280                 1285                 1290             


Glu Met  Tyr Val Lys Trp Pro  Trp Tyr Val Trp Leu  Leu Ile Ser 
    1295                 1300                 1305             


Phe Ser  Phe Ile Ile Phe Leu  Val Leu Leu Phe Phe  Ile Cys Cys 
    1310                 1315                 1320             


Cys Thr  Gly Cys Gly Ser Ala  Cys Phe Ser Lys Cys  His Asn Cys 
    1325                 1330                 1335             


Cys Asp  Glu Tyr Gly Gly His  His Asp Phe Val Ile  Lys Thr Ser 
    1340                 1345                 1350             


His Asp  Asp 
    1355     


<210>  17
<211>  4071
<212>  DNA
<213>  coronavirus

<400>  17
atgaaacttt tcttgatttt gcttgttttg cccctggcct cttgcttttt cacatgtaat     60

agtaatgcta atctctctat gttacaatta ggtgttcctg acaattcttc aactattgtt    120

acgggtttat tgccaactca ttggttttgt gctaatcaga gtacatctgt ttactcagcc    180

aatggtttct tttatattga tgttggtaat caccgtagtg cttttgcgct ccatactggt    240

tattatgatg ctaatcagta ttatatttat gttactaatg aaataggctt aaatgcttct    300

gttactctta agatttgtaa gtttagtaga aacactactt ttgatttttt aagtaatgct    360

tctagttctt ttgactgtat agttaatttg ttatttacag aacagttagg tgcgcctttg    420

ggcataacta tatctggtga aactgtgcgt ctgcatttat ataatgtaac tcgtactttt    480

tatgtgccag cagcttataa acttactaaa cttagtgtta aatgttactt taactattcc    540

tgtgttttta gtgttgtcaa cgccaccgtt actgtgaatg tcaccacaca taatggccgt    600

gtagttaact acactgtttg tgatgattgt aatggttata ctgataacat attttctgtt    660

caacaggatg gccgcattcc taatggtttc ccttttaata attggttttt gttaactaat    720

ggttccacac tagtggacgg ggtctctaga ctttatcaac cactccgttt aacttgttta    780

tggcctgtac ctggtcttaa atcttcaact ggttttgttt attttaatgc cactggttct    840

gatgttaatt gtaacggcta tcaacataat tctgttgttg atgttatgcg ttacaatctt    900

aacttcagtg ctaattcttt ggacaatctc aagagtggtg ttatagtttt taaaacttta    960

cagtacgatg ttttgtttta ttgtagtaat tcttcctcag gtgttcttga caccacaata   1020

ccttttggcc cgtcctctca accttattac tgttttataa acagcactat caacactact   1080

catgttagca cttttgtggg tattttacca cccactgtgc gtgaaattgt tgttgctaga   1140

actggccagt tttatattaa tggttttaag tatttcgatt tgggtttcat agaagctgtc   1200

aattttaatg tcacgactgc tagcgccaca gatttttgga cggttgcatt tgctactttt   1260

gttgatgttt tggttaatgt tagtgcaact aacattcaaa acttacttta ttgcgattct   1320

ccatttgaaa agttgcagtg tgagcacttg cagtttggat tgcaggatgg tttttattct   1380

gcaaattttc ttgatgataa tgttttgcct gagacttatg ttgcactccc catttattat   1440

caacacacgg acataaattt tactgcaact gcatcttttg gtggttcttg ttatgtttgt   1500

aaaccacacc aggttaatat atctcttaat ggtaacactt cagtgtgtgt tagaacatct   1560

catttttcaa ttaggtatat ttataaccgc gttaagagtg gttcaccagg tgactcttca   1620

tggcacattt atttaaagag tggcacttgt ccattttctt tttctaagtt aaataatttt   1680

caaaagttca agactatttg tttctcaacc gtcgaagtgc ctggtagttg taattttccg   1740

cttgaagcca cctggcatta cacttcttat actattgttg gtgctttgta tgttacttgg   1800

tctgaaggta attctattac tggtgtacct tatcctgtct ctggtattcg tgagtttagt   1860

aatttagttt taaataattg taccaaatat aatatttatg attatgttgg tactggaatt   1920

atacgttctt caaaccagtc acttgctggt ggtattacat atgtttctaa ctctggtaat   1980

ttacttggtt ttaaaaatgt ttccactggt aacattttta ttgtgacacc atgtaaccaa   2040

ccagaccaag tagctgttta tcaacaaagc attattggtg ccatgaccgc tgttaatgag   2100

tctagatatg gcttgcaaaa cttactacag ttacctaact tttattatgt tagtaatggt   2160

ggtaacaatt gcactacggc cgttatgact tattctaatt ttggtatttg tgctgatggt   2220

tctttgattc ctgttcgtcc gcgtaattct agtgataatg gtatttcagc cataatcact   2280

gctaatttat ccattccttc taactggact acttcagttc aagttgagta cctccaaatt   2340

actagtactc caatagttgt tgattgtgct acttatgtgt gtaatggtaa ccctcgctgt   2400

aagaatctac ttaagcagta tacttctgct tgtaaaacta ttgaagatgc cttacgactt   2460

agtgctcatt tggaaactaa tgatgttagt agtatgctaa ctttcgatag caatgctttt   2520

agtttggcta atgttactag ttttggagat tataaccttt ctagtgtttt acctcagaga   2580

aacattcgtt caagccgtat agcaggacgt agtgctttgg aagatttgtt gtttagcaaa   2640

gttgttacat ctggtttggg tactgttgat gttgactata agtcttgtac taaaggtctt   2700

tctattgctg accttgcttg tgctcagtac tacaatggca taatggtttt gccaggtgtt   2760

gctgatgctg aacgtatggc catgtacaca ggttctctta taggtggcat ggtgctcgga   2820

ggtcttacat cagcagccgc catacctttt tctttggcac tgcaagcacg acttaactat   2880

gttgctttac aaactgatgt gcttcaagaa aatcagaaaa ttttggctgc atcatttaat   2940

aaggctatta ataatattgt tgcttctttt agtagcgtta atgatgctat tacacaaact   3000

gcagaggcta tacatactgt tactattgca cttaataaga ttcaggatgt tgttaatcaa   3060

cagggtagtg ctcttaacca tctcacttca caattgagac ataattttca ggccatttct   3120

aattcaattc aggctattta tgaccggctt gattcaattc aagccgatca acaagttgac   3180

agattaatta ctggacggct tgcagctttg aatgcatttg tttcccaagt tttgaataaa   3240

tatactgaag ttcgtggttc aagacgctta gcacagcaga agattaatga atgtgtcaag   3300

tcacaatcta atagatatgg tttttgtggc aatggcactc acatcttttc aatcgtcaac   3360

tcagctccag atggtttgct ttttcttcat actgttttgc tgccaactga ttacaagaat   3420

gtaaaggcgt ggtctggtat ctgtgttgat ggcatttatg gctatgttct gcgtcaacct   3480

aacttggttc tttattctga taatggtgtc tttcgtgtaa cttccagggt catgtttcaa   3540

cctcgcttac ctgttttgtc tgattttgtg caaatatata attgtaatgt tacttttgtt   3600

aacatatctc gtgttgagtt acatactgtc atacctgact acgttgatgt taataaaaca   3660

ttacaagagt ttgcacaaaa cttaccaaag tatgttaagc ctaattttga cttgactcct   3720

tttaatttaa catatcttaa tttgagttct gagttgaagc aactcgaagc taaaactgct   3780

agtctttttc aaactactgt tgaattacaa ggtcttattg atcagattaa cagtacatat   3840

gttgatttga agttgcttaa taggtttgaa aattatatca aatggccttg gtgggtttgg   3900

ctcattattt ctgttgtttt tgttgtattg ttgagtcttc ttgtgttttg ttgtctttct   3960

acaggttgtt gtggttgttg caattgttta acttcatcaa tgcgaggctg ttgtgattgt   4020

ggttcaacta aacttcctta ttacgaattt gaaaaggtcc acgttcaata a            4071


<210>  18
<211>  1356
<212>  PRT
<213>  coronavirus

<400>  18

Met Lys Leu Phe Leu Ile Leu Leu Val Leu Pro Leu Ala Ser Cys Phe 
1               5                   10                  15      


Phe Thr Cys Asn Ser Asn Ala Asn Leu Ser Met Leu Gln Leu Gly Val 
            20                  25                  30          


Pro Asp Asn Ser Ser Thr Ile Val Thr Gly Leu Leu Pro Thr His Trp 
        35                  40                  45              


Phe Cys Ala Asn Gln Ser Thr Ser Val Tyr Ser Ala Asn Gly Phe Phe 
    50                  55                  60                  


Tyr Ile Asp Val Gly Asn His Arg Ser Ala Phe Ala Leu His Thr Gly 
65                  70                  75                  80  


Tyr Tyr Asp Ala Asn Gln Tyr Tyr Ile Tyr Val Thr Asn Glu Ile Gly 
                85                  90                  95      


Leu Asn Ala Ser Val Thr Leu Lys Ile Cys Lys Phe Ser Arg Asn Thr 
            100                 105                 110         


Thr Phe Asp Phe Leu Ser Asn Ala Ser Ser Ser Phe Asp Cys Ile Val 
        115                 120                 125             


Asn Leu Leu Phe Thr Glu Gln Leu Gly Ala Pro Leu Gly Ile Thr Ile 
    130                 135                 140                 


Ser Gly Glu Thr Val Arg Leu His Leu Tyr Asn Val Thr Arg Thr Phe 
145                 150                 155                 160 


Tyr Val Pro Ala Ala Tyr Lys Leu Thr Lys Leu Ser Val Lys Cys Tyr 
                165                 170                 175     


Phe Asn Tyr Ser Cys Val Phe Ser Val Val Asn Ala Thr Val Thr Val 
            180                 185                 190         


Asn Val Thr Thr His Asn Gly Arg Val Val Asn Tyr Thr Val Cys Asp 
        195                 200                 205             


Asp Cys Asn Gly Tyr Thr Asp Asn Ile Phe Ser Val Gln Gln Asp Gly 
    210                 215                 220                 


Arg Ile Pro Asn Gly Phe Pro Phe Asn Asn Trp Phe Leu Leu Thr Asn 
225                 230                 235                 240 


Gly Ser Thr Leu Val Asp Gly Val Ser Arg Leu Tyr Gln Pro Leu Arg 
                245                 250                 255     


Leu Thr Cys Leu Trp Pro Val Pro Gly Leu Lys Ser Ser Thr Gly Phe 
            260                 265                 270         


Val Tyr Phe Asn Ala Thr Gly Ser Asp Val Asn Cys Asn Gly Tyr Gln 
        275                 280                 285             


His Asn Ser Val Val Asp Val Met Arg Tyr Asn Leu Asn Phe Ser Ala 
    290                 295                 300                 


Asn Ser Leu Asp Asn Leu Lys Ser Gly Val Ile Val Phe Lys Thr Leu 
305                 310                 315                 320 


Gln Tyr Asp Val Leu Phe Tyr Cys Ser Asn Ser Ser Ser Gly Val Leu 
                325                 330                 335     


Asp Thr Thr Ile Pro Phe Gly Pro Ser Ser Gln Pro Tyr Tyr Cys Phe 
            340                 345                 350         


Ile Asn Ser Thr Ile Asn Thr Thr His Val Ser Thr Phe Val Gly Ile 
        355                 360                 365             


Leu Pro Pro Thr Val Arg Glu Ile Val Val Ala Arg Thr Gly Gln Phe 
    370                 375                 380                 


Tyr Ile Asn Gly Phe Lys Tyr Phe Asp Leu Gly Phe Ile Glu Ala Val 
385                 390                 395                 400 


Asn Phe Asn Val Thr Thr Ala Ser Ala Thr Asp Phe Trp Thr Val Ala 
                405                 410                 415     


Phe Ala Thr Phe Val Asp Val Leu Val Asn Val Ser Ala Thr Asn Ile 
            420                 425                 430         


Gln Asn Leu Leu Tyr Cys Asp Ser Pro Phe Glu Lys Leu Gln Cys Glu 
        435                 440                 445             


His Leu Gln Phe Gly Leu Gln Asp Gly Phe Tyr Ser Ala Asn Phe Leu 
    450                 455                 460                 


Asp Asp Asn Val Leu Pro Glu Thr Tyr Val Ala Leu Pro Ile Tyr Tyr 
465                 470                 475                 480 


Gln His Thr Asp Ile Asn Phe Thr Ala Thr Ala Ser Phe Gly Gly Ser 
                485                 490                 495     


Cys Tyr Val Cys Lys Pro His Gln Val Asn Ile Ser Leu Asn Gly Asn 
            500                 505                 510         


Thr Ser Val Cys Val Arg Thr Ser His Phe Ser Ile Arg Tyr Ile Tyr 
        515                 520                 525             


Asn Arg Val Lys Ser Gly Ser Pro Gly Asp Ser Ser Trp His Ile Tyr 
    530                 535                 540                 


Leu Lys Ser Gly Thr Cys Pro Phe Ser Phe Ser Lys Leu Asn Asn Phe 
545                 550                 555                 560 


Gln Lys Phe Lys Thr Ile Cys Phe Ser Thr Val Glu Val Pro Gly Ser 
                565                 570                 575     


Cys Asn Phe Pro Leu Glu Ala Thr Trp His Tyr Thr Ser Tyr Thr Ile 
            580                 585                 590         


Val Gly Ala Leu Tyr Val Thr Trp Ser Glu Gly Asn Ser Ile Thr Gly 
        595                 600                 605             


Val Pro Tyr Pro Val Ser Gly Ile Arg Glu Phe Ser Asn Leu Val Leu 
    610                 615                 620                 


Asn Asn Cys Thr Lys Tyr Asn Ile Tyr Asp Tyr Val Gly Thr Gly Ile 
625                 630                 635                 640 


Ile Arg Ser Ser Asn Gln Ser Leu Ala Gly Gly Ile Thr Tyr Val Ser 
                645                 650                 655     


Asn Ser Gly Asn Leu Leu Gly Phe Lys Asn Val Ser Thr Gly Asn Ile 
            660                 665                 670         


Phe Ile Val Thr Pro Cys Asn Gln Pro Asp Gln Val Ala Val Tyr Gln 
        675                 680                 685             


Gln Ser Ile Ile Gly Ala Met Thr Ala Val Asn Glu Ser Arg Tyr Gly 
    690                 695                 700                 


Leu Gln Asn Leu Leu Gln Leu Pro Asn Phe Tyr Tyr Val Ser Asn Gly 
705                 710                 715                 720 


Gly Asn Asn Cys Thr Thr Ala Val Met Thr Tyr Ser Asn Phe Gly Ile 
                725                 730                 735     


Cys Ala Asp Gly Ser Leu Ile Pro Val Arg Pro Arg Asn Ser Ser Asp 
            740                 745                 750         


Asn Gly Ile Ser Ala Ile Ile Thr Ala Asn Leu Ser Ile Pro Ser Asn 
        755                 760                 765             


Trp Thr Thr Ser Val Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro 
    770                 775                 780                 


Ile Val Val Asp Cys Ala Thr Tyr Val Cys Asn Gly Asn Pro Arg Cys 
785                 790                 795                 800 


Lys Asn Leu Leu Lys Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp 
                805                 810                 815     


Ala Leu Arg Leu Ser Ala His Leu Glu Thr Asn Asp Val Ser Ser Met 
            820                 825                 830         


Leu Thr Phe Asp Ser Asn Ala Phe Ser Leu Ala Asn Val Thr Ser Phe 
        835                 840                 845             


Gly Asp Tyr Asn Leu Ser Ser Val Leu Pro Gln Arg Asn Ile Arg Ser 
    850                 855                 860                 


Ser Arg Ile Ala Gly Arg Ser Ala Leu Glu Asp Leu Leu Phe Ser Lys 
865                 870                 875                 880 


Val Val Thr Ser Gly Leu Gly Thr Val Asp Val Asp Tyr Lys Ser Cys 
                885                 890                 895     


Thr Lys Gly Leu Ser Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn 
            900                 905                 910         


Gly Ile Met Val Leu Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met 
        915                 920                 925             


Tyr Thr Gly Ser Leu Ile Gly Gly Met Val Leu Gly Gly Leu Thr Ser 
    930                 935                 940                 


Ala Ala Ala Ile Pro Phe Ser Leu Ala Leu Gln Ala Arg Leu Asn Tyr 
945                 950                 955                 960 


Val Ala Leu Gln Thr Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala 
                965                 970                 975     


Ala Ser Phe Asn Lys Ala Ile Asn Asn Ile Val Ala Ser Phe Ser Ser 
            980                 985                 990         


Val Asn Asp Ala Ile Thr Gln Thr  Ala Glu Ala Ile His  Thr Val Thr 
        995                 1000                 1005             


Ile Ala  Leu Asn Lys Ile Gln  Asp Val Val Asn Gln  Gln Gly Ser 
    1010                 1015                 1020             


Ala Leu  Asn His Leu Thr Ser  Gln Leu Arg His Asn  Phe Gln Ala 
    1025                 1030                 1035             


Ile Ser  Asn Ser Ile Gln Ala  Ile Tyr Asp Arg Leu  Asp Ser Ile 
    1040                 1045                 1050             


Gln Ala  Asp Gln Gln Val Asp  Arg Leu Ile Thr Gly  Arg Leu Ala 
    1055                 1060                 1065             


Ala Leu  Asn Ala Phe Val Ser  Gln Val Leu Asn Lys  Tyr Thr Glu 
    1070                 1075                 1080             


Val Arg  Gly Ser Arg Arg Leu  Ala Gln Gln Lys Ile  Asn Glu Cys 
    1085                 1090                 1095             


Val Lys  Ser Gln Ser Asn Arg  Tyr Gly Phe Cys Gly  Asn Gly Thr 
    1100                 1105                 1110             


His Ile  Phe Ser Ile Val Asn  Ser Ala Pro Asp Gly  Leu Leu Phe 
    1115                 1120                 1125             


Leu His  Thr Val Leu Leu Pro  Thr Asp Tyr Lys Asn  Val Lys Ala 
    1130                 1135                 1140             


Trp Ser  Gly Ile Cys Val Asp  Gly Ile Tyr Gly Tyr  Val Leu Arg 
    1145                 1150                 1155             


Gln Pro  Asn Leu Val Leu Tyr  Ser Asp Asn Gly Val  Phe Arg Val 
    1160                 1165                 1170             


Thr Ser  Arg Val Met Phe Gln  Pro Arg Leu Pro Val  Leu Ser Asp 
    1175                 1180                 1185             


Phe Val  Gln Ile Tyr Asn Cys  Asn Val Thr Phe Val  Asn Ile Ser 
    1190                 1195                 1200             


Arg Val  Glu Leu His Thr Val  Ile Pro Asp Tyr Val  Asp Val Asn 
    1205                 1210                 1215             


Lys Thr  Leu Gln Glu Phe Ala  Gln Asn Leu Pro Lys  Tyr Val Lys 
    1220                 1225                 1230             


Pro Asn  Phe Asp Leu Thr Pro  Phe Asn Leu Thr Tyr  Leu Asn Leu 
    1235                 1240                 1245             


Ser Ser  Glu Leu Lys Gln Leu  Glu Ala Lys Thr Ala  Ser Leu Phe 
    1250                 1255                 1260             


Gln Thr  Thr Val Glu Leu Gln  Gly Leu Ile Asp Gln  Ile Asn Ser 
    1265                 1270                 1275             


Thr Tyr  Val Asp Leu Lys Leu  Leu Asn Arg Phe Glu  Asn Tyr Ile 
    1280                 1285                 1290             


Lys Trp  Pro Trp Trp Val Trp  Leu Ile Ile Ser Val  Val Phe Val 
    1295                 1300                 1305             


Val Leu  Leu Ser Leu Leu Val  Phe Cys Cys Leu Ser  Thr Gly Cys 
    1310                 1315                 1320             


Cys Gly  Cys Cys Asn Cys Leu  Thr Ser Ser Met Arg  Gly Cys Cys 
    1325                 1330                 1335             


Asp Cys  Gly Ser Thr Lys Leu  Pro Tyr Tyr Glu Phe  Glu Lys Val 
    1340                 1345                 1350             


His Val  Gln 
    1355     


<210>  19
<211>  3522
<212>  DNA
<213>  coronavirus

<400>  19
atgtttgttt tgcttgttgc atatgccttg ttgcatattg ctggttgtca aactacaaat     60

gggctgaaca ctagttactc tgtttgcaac ggctgtgttg gttattcaga aaatgtattt    120

gctgttgaga gtggtggtta tataccctcc gactttgcat tcaataattg gttccttcta    180

actaatacct catctgttgt agatggtgtt gtgaggagtt ttcagccttt gttgcttaat    240

tgcttatggt ctgtttctgg cttgcggttt actactggtt ttgtctattt taatggtact    300

gggagaggtg attgtaaagg tttttcctca gatgttttgt ctgatgtcat acgttacaac    360

ctcaattttg aagaaaacct tagacgtgga accattttgt ttaaaacatc ttatggtgtt    420

gttgtgtttt attgtaccaa caacacttta gtttcaggtg atgctcacat accatttggt    480

acagttttgg gcaattttta ttgctttgta aatactacta ttggcaatga aactacgtct    540

gcttttgtgg gtgcactacc taagacagtt cgtgagtttg ttatttcacg cacaggacat    600

ttttatatta atggctatcg ctatttcact ttaggtaatg tagaagccgt taatttcaat    660

gtcactactg cagaaaccac tgatttttgt actgttgcgt tagcttctta tgctgacgtt    720

ttggttaatg tgtcacaaac ctctattgct aatataattt attgcaactc tgttattaac    780

agactgagat gtgaccagtt gtcctttgat gtaccagatg gtttttattc tacaagccct    840

attcaatccg ttgagctacc tgtgtctatt gtgtcgctac ctgtttatca taaacatacg    900

tttattgtgt tgtacgttga cttcaaacct cagagtggcg gtggcaagtg ctttaactgt    960

tatcctgctg gtgttaatat tacactggcc aattttaatg aaactaaagg gcctttgtgt   1020

gttgacacat cacacttcac taccaaatac gttgctgttt atgccaatgt tggtaggtgg   1080

agtgctagta ttaacacggg aaattgccct ttttcttttg gcaaagttaa taactttgtt   1140

aaatttggca gtgtatgttt ttcgctaaag gatatacccg gtggttgcgc aatgcctata   1200

gtggctaatt gggcttatag taagtactat actataggct cattgtatgt ttcttggagt   1260

gatggtgatg gaattactgg cgtcccacaa cctgttgagg gtgttagttc ctttatgaat   1320

gttacattgg acaaatgtac taaatataat atttatgatg tatctggtgt gggtgttatt   1380

cgcgttagca atgacacctt tcttaatgga attacgtaca catcaacttc aggtaacctt   1440

ctgggtttta aagatgttac taagggcacc atctactcta tcactccttg taacccacca   1500

gatcagcttg ttgtttatca gcaagctgtt gttggtgcta tgttgtctga aaattttact   1560

agttacggct tttctaatgt tgtagaactg ccgaaatttt tctatgcgtc caatggcact   1620

tataattgca cagacgctgt tttaacttat tctagttttg gcgtttgtgc agatggttct   1680

ataattgctg ttcaaccacg taatgtttca tatgatagtg tttcagctat cgtcacagct   1740

aatttgtcta taccttccaa ttggaccact tcggtccagg ttgagtattt acaaattaca   1800

agtacaccta tcgtagttga ttgctccact tatgtttgca atggtaatgt gcgctgtgtt   1860

gaattgctta agcagtatac ttctgcttgt aaaactattg aagacgcctt aagaaatagc   1920

gccaggctgg agtctgcaga tgttagtgag atgctcactt ttgacaagaa agcgtttaca   1980

cttgctaatg ttagtagttt tggtgactac aaccttagca gcgtcatacc tagcttgccc   2040

acaagtggta gtagagtggc tggtcgcagt gccatagaag acatactttt tagcaaactt   2100

gttacttctg gacttggcac tgtggacgca gactacaaaa agtgcactaa gggtctttcc   2160

attgctgact tggcttgtgc tcaatattat aatggcatta tggttttgcc tggcgtcgct   2220

gatgctgaac gaatggccat gtatacaggt tctttaattg gtggaattgc tttaggaggt   2280

ctaacatcag ccgtttcaat accattttca ttagcaattc aggcacgttt aaattatgtt   2340

gcattgcaga ctgatgtttt acaagaaaat cagaaaattc ttgctgcatc ttttaacaaa   2400

gcaatgacca acatagtaga tgcctttact ggtgttaatg atgctattac acaaacttca   2460

caagccctac aaacagttgc tactgcactt aacaagatcc aggatgttgt taatcaacaa   2520

ggcaactcat tgaaccattt aacttctcag ttgaggcaga attttcaagc tatctctagc   2580

tctattcagg ctatctatga cagacttgac actattcagg ctgatcaaca agtagatagg   2640

ctgattactg gtagattggc tgctttgaat gtattcgttt ctcatacatt gactaagtac   2700

actgaagttc gtgcttccag acagcttgca caacaaaaag tgaatgagtg tgtcaaatcc   2760

cagtctaagc gttatggctt ctgtggaaat ggcactcaca ttttctcaat tgttaatgct   2820

gctcctgagg ggcttgtttt tctccacact gtcttgttgc cgacacaata taaggatgtt   2880

gaagcgtggt ctgggttgtg cgttgatggt acaaacggtt atgtgttgcg acaacctaat   2940

cttgctcttt acaaagaagg caattattat agaatcacat ctcgcataat gtttgaacca   3000

cgtattccta ccatggcaga ttttgttcaa attgaaaatt gcaatgtcac atttgttaac   3060

atttctcgct ctgagttgca aaccattgtg ccagagtata ttgatgttaa taagacgctg   3120

caagaattaa gttacaaatt gccaaattac actgttccag acctagttgt cgaacagtac   3180

aaccagacta ttttgaattt gaccagtgaa attagcaccc ttgaaaataa atctgcggag   3240

cttaattaca ctgttcaaaa attgcaaact ctgattgaca acataaatag cacattagtc   3300

gacttaaagt ggctcaaccg ggttgagact tacatcaagt ggccgtggtg ggtgtggttg   3360

tgcatttcag tcgtgctcat ctttgtggtg agtatgttgc tattatgttg ttgttctact   3420

ggttgctgtg gcttctttag ttgttttgca tcttctatta gaggttgttg tgaatcaact   3480

aaacttcctt attacgacgt tgaaaagatc cacatacagt aa                      3522


<210>  20
<211>  1173
<212>  PRT
<213>  coronavirus

<400>  20

Met Phe Val Leu Leu Val Ala Tyr Ala Leu Leu His Ile Ala Gly Cys 
1               5                   10                  15      


Gln Thr Thr Asn Gly Leu Asn Thr Ser Tyr Ser Val Cys Asn Gly Cys 
            20                  25                  30          


Val Gly Tyr Ser Glu Asn Val Phe Ala Val Glu Ser Gly Gly Tyr Ile 
        35                  40                  45              


Pro Ser Asp Phe Ala Phe Asn Asn Trp Phe Leu Leu Thr Asn Thr Ser 
    50                  55                  60                  


Ser Val Val Asp Gly Val Val Arg Ser Phe Gln Pro Leu Leu Leu Asn 
65                  70                  75                  80  


Cys Leu Trp Ser Val Ser Gly Leu Arg Phe Thr Thr Gly Phe Val Tyr 
                85                  90                  95      


Phe Asn Gly Thr Gly Arg Gly Asp Cys Lys Gly Phe Ser Ser Asp Val 
            100                 105                 110         


Leu Ser Asp Val Ile Arg Tyr Asn Leu Asn Phe Glu Glu Asn Leu Arg 
        115                 120                 125             


Arg Gly Thr Ile Leu Phe Lys Thr Ser Tyr Gly Val Val Val Phe Tyr 
    130                 135                 140                 


Cys Thr Asn Asn Thr Leu Val Ser Gly Asp Ala His Ile Pro Phe Gly 
145                 150                 155                 160 


Thr Val Leu Gly Asn Phe Tyr Cys Phe Val Asn Thr Thr Ile Gly Asn 
                165                 170                 175     


Glu Thr Thr Ser Ala Phe Val Gly Ala Leu Pro Lys Thr Val Arg Glu 
            180                 185                 190         


Phe Val Ile Ser Arg Thr Gly His Phe Tyr Ile Asn Gly Tyr Arg Tyr 
        195                 200                 205             


Phe Thr Leu Gly Asn Val Glu Ala Val Asn Phe Asn Val Thr Thr Ala 
    210                 215                 220                 


Glu Thr Thr Asp Phe Cys Thr Val Ala Leu Ala Ser Tyr Ala Asp Val 
225                 230                 235                 240 


Leu Val Asn Val Ser Gln Thr Ser Ile Ala Asn Ile Ile Tyr Cys Asn 
                245                 250                 255     


Ser Val Ile Asn Arg Leu Arg Cys Asp Gln Leu Ser Phe Asp Val Pro 
            260                 265                 270         


Asp Gly Phe Tyr Ser Thr Ser Pro Ile Gln Ser Val Glu Leu Pro Val 
        275                 280                 285             


Ser Ile Val Ser Leu Pro Val Tyr His Lys His Thr Phe Ile Val Leu 
    290                 295                 300                 


Tyr Val Asp Phe Lys Pro Gln Ser Gly Gly Gly Lys Cys Phe Asn Cys 
305                 310                 315                 320 


Tyr Pro Ala Gly Val Asn Ile Thr Leu Ala Asn Phe Asn Glu Thr Lys 
                325                 330                 335     


Gly Pro Leu Cys Val Asp Thr Ser His Phe Thr Thr Lys Tyr Val Ala 
            340                 345                 350         


Val Tyr Ala Asn Val Gly Arg Trp Ser Ala Ser Ile Asn Thr Gly Asn 
        355                 360                 365             


Cys Pro Phe Ser Phe Gly Lys Val Asn Asn Phe Val Lys Phe Gly Ser 
    370                 375                 380                 


Val Cys Phe Ser Leu Lys Asp Ile Pro Gly Gly Cys Ala Met Pro Ile 
385                 390                 395                 400 


Val Ala Asn Trp Ala Tyr Ser Lys Tyr Tyr Thr Ile Gly Ser Leu Tyr 
                405                 410                 415     


Val Ser Trp Ser Asp Gly Asp Gly Ile Thr Gly Val Pro Gln Pro Val 
            420                 425                 430         


Glu Gly Val Ser Ser Phe Met Asn Val Thr Leu Asp Lys Cys Thr Lys 
        435                 440                 445             


Tyr Asn Ile Tyr Asp Val Ser Gly Val Gly Val Ile Arg Val Ser Asn 
    450                 455                 460                 


Asp Thr Phe Leu Asn Gly Ile Thr Tyr Thr Ser Thr Ser Gly Asn Leu 
465                 470                 475                 480 


Leu Gly Phe Lys Asp Val Thr Lys Gly Thr Ile Tyr Ser Ile Thr Pro 
                485                 490                 495     


Cys Asn Pro Pro Asp Gln Leu Val Val Tyr Gln Gln Ala Val Val Gly 
            500                 505                 510         


Ala Met Leu Ser Glu Asn Phe Thr Ser Tyr Gly Phe Ser Asn Val Val 
        515                 520                 525             


Glu Leu Pro Lys Phe Phe Tyr Ala Ser Asn Gly Thr Tyr Asn Cys Thr 
    530                 535                 540                 


Asp Ala Val Leu Thr Tyr Ser Ser Phe Gly Val Cys Ala Asp Gly Ser 
545                 550                 555                 560 


Ile Ile Ala Val Gln Pro Arg Asn Val Ser Tyr Asp Ser Val Ser Ala 
                565                 570                 575     


Ile Val Thr Ala Asn Leu Ser Ile Pro Ser Asn Trp Thr Thr Ser Val 
            580                 585                 590         


Gln Val Glu Tyr Leu Gln Ile Thr Ser Thr Pro Ile Val Val Asp Cys 
        595                 600                 605             


Ser Thr Tyr Val Cys Asn Gly Asn Val Arg Cys Val Glu Leu Leu Lys 
    610                 615                 620                 


Gln Tyr Thr Ser Ala Cys Lys Thr Ile Glu Asp Ala Leu Arg Asn Ser 
625                 630                 635                 640 


Ala Arg Leu Glu Ser Ala Asp Val Ser Glu Met Leu Thr Phe Asp Lys 
                645                 650                 655     


Lys Ala Phe Thr Leu Ala Asn Val Ser Ser Phe Gly Asp Tyr Asn Leu 
            660                 665                 670         


Ser Ser Val Ile Pro Ser Leu Pro Thr Ser Gly Ser Arg Val Ala Gly 
        675                 680                 685             


Arg Ser Ala Ile Glu Asp Ile Leu Phe Ser Lys Leu Val Thr Ser Gly 
    690                 695                 700                 


Leu Gly Thr Val Asp Ala Asp Tyr Lys Lys Cys Thr Lys Gly Leu Ser 
705                 710                 715                 720 


Ile Ala Asp Leu Ala Cys Ala Gln Tyr Tyr Asn Gly Ile Met Val Leu 
                725                 730                 735     


Pro Gly Val Ala Asp Ala Glu Arg Met Ala Met Tyr Thr Gly Ser Leu 
            740                 745                 750         


Ile Gly Gly Ile Ala Leu Gly Gly Leu Thr Ser Ala Val Ser Ile Pro 
        755                 760                 765             


Phe Ser Leu Ala Ile Gln Ala Arg Leu Asn Tyr Val Ala Leu Gln Thr 
    770                 775                 780                 


Asp Val Leu Gln Glu Asn Gln Lys Ile Leu Ala Ala Ser Phe Asn Lys 
785                 790                 795                 800 


Ala Met Thr Asn Ile Val Asp Ala Phe Thr Gly Val Asn Asp Ala Ile 
                805                 810                 815     


Thr Gln Thr Ser Gln Ala Leu Gln Thr Val Ala Thr Ala Leu Asn Lys 
            820                 825                 830         


Ile Gln Asp Val Val Asn Gln Gln Gly Asn Ser Leu Asn His Leu Thr 
        835                 840                 845             


Ser Gln Leu Arg Gln Asn Phe Gln Ala Ile Ser Ser Ser Ile Gln Ala 
    850                 855                 860                 


Ile Tyr Asp Arg Leu Asp Thr Ile Gln Ala Asp Gln Gln Val Asp Arg 
865                 870                 875                 880 


Leu Ile Thr Gly Arg Leu Ala Ala Leu Asn Val Phe Val Ser His Thr 
                885                 890                 895     


Leu Thr Lys Tyr Thr Glu Val Arg Ala Ser Arg Gln Leu Ala Gln Gln 
            900                 905                 910         


Lys Val Asn Glu Cys Val Lys Ser Gln Ser Lys Arg Tyr Gly Phe Cys 
        915                 920                 925             


Gly Asn Gly Thr His Ile Phe Ser Ile Val Asn Ala Ala Pro Glu Gly 
    930                 935                 940                 


Leu Val Phe Leu His Thr Val Leu Leu Pro Thr Gln Tyr Lys Asp Val 
945                 950                 955                 960 


Glu Ala Trp Ser Gly Leu Cys Val Asp Gly Thr Asn Gly Tyr Val Leu 
                965                 970                 975     


Arg Gln Pro Asn Leu Ala Leu Tyr Lys Glu Gly Asn Tyr Tyr Arg Ile 
            980                 985                 990         


Thr Ser Arg Ile Met Phe Glu Pro  Arg Ile Pro Thr Met  Ala Asp Phe 
        995                 1000                 1005             


Val Gln  Ile Glu Asn Cys Asn  Val Thr Phe Val Asn  Ile Ser Arg 
    1010                 1015                 1020             


Ser Glu  Leu Gln Thr Ile Val  Pro Glu Tyr Ile Asp  Val Asn Lys 
    1025                 1030                 1035             


Thr Leu  Gln Glu Leu Ser Tyr  Lys Leu Pro Asn Tyr  Thr Val Pro 
    1040                 1045                 1050             


Asp Leu  Val Val Glu Gln Tyr  Asn Gln Thr Ile Leu  Asn Leu Thr 
    1055                 1060                 1065             


Ser Glu  Ile Ser Thr Leu Glu  Asn Lys Ser Ala Glu  Leu Asn Tyr 
    1070                 1075                 1080             


Thr Val  Gln Lys Leu Gln Thr  Leu Ile Asp Asn Ile  Asn Ser Thr 
    1085                 1090                 1095             


Leu Val  Asp Leu Lys Trp Leu  Asn Arg Val Glu Thr  Tyr Ile Lys 
    1100                 1105                 1110             


Trp Pro  Trp Trp Val Trp Leu  Cys Ile Ser Val Val  Leu Ile Phe 
    1115                 1120                 1125             


Val Val  Ser Met Leu Leu Leu  Cys Cys Cys Ser Thr  Gly Cys Cys 
    1130                 1135                 1140             


Gly Phe  Phe Ser Cys Phe Ala  Ser Ser Ile Arg Gly  Cys Cys Glu 
    1145                 1150                 1155             


Ser Thr  Lys Leu Pro Tyr Tyr  Asp Val Glu Lys Ile  His Ile Gln 
    1160                 1165                 1170             


<210>  21
<211>  3822
<212>  DNA
<213>  coronavirus

<400>  21
atgtttgttt ttcttgtttt attgccacta gtctctagtc agtgtgttaa tcttacaacc     60

agaactcaat taccccctgc atacactaat tctttcacac gtggtgttta ttaccctgac    120

aaagttttca gatcctcagt tttacattca actcaggact tgttcttacc tttcttttcc    180

aatgttactt ggttccatgc tatacatgtc tctgggacca atggtactaa gaggtttgat    240

aaccctgtcc taccatttaa tgatggtgtt tattttgctt ccactgagaa gtctaacata    300

ataagaggct ggatttttgg tactacttta gattcgaaga cccagtccct acttattgtt    360

aataacgcta ctaatgttgt tattaaagtc tgtgaatttc aattttgtaa tgatccattt    420

ttgggtgttt attaccacaa aaacaacaaa agttggatgg aaagtgagtt cagagtttat    480

tctagtgcga ataattgcac ttttgaatat gtctctcagc cttttcttat ggaccttgaa    540

ggaaaacagg gtaatttcaa aaatcttagg gaatttgtgt ttaagaatat tgatggttat    600

tttaaaatat attctaagca cacgcctatt aatttagtgc gtgatctccc tcagggtttt    660

tcggctttag aaccattggt agatttgcca ataggtatta acatcactag gtttcaaact    720

ttacttgctt tacatagaag ttatttgact cctggtgatt cttcttcagg ttggacagct    780

ggtgctgcag cttattatgt gggttatctt caacctagga cttttctatt aaaatataat    840

gaaaatggaa ccattacaga tgctgtagac tgtgcacttg accctctctc agaaacaaag    900

tgtacgttga aatccttcac tgtagaaaaa ggaatctatc aaacttctaa ctttagagtc    960

caaccaacag aatctattgt tagatttcct aatattacaa acttgtgccc ttttggtgaa   1020

gtttttaacg ccaccagatt tgcatctgtt tatgcttgga acaggaagag aatcagcaac   1080

tgtgttgctg attattctgt cctatataat tccgcatcat tttccacttt taagtgttat   1140

ggagtgtctc ctactaaatt aaatgatctc tgctttacta atgtctatgc agattcattt   1200

gtaattagag gtgatgaagt cagacaaatc gctccagggc aaactggaaa gattgctgat   1260

tataattata aattaccaga tgattttaca ggctgcgtta tagcttggaa ttctaacaat   1320

cttgattcta aggttggtgg taattataat tacctgtata gattgtttag gaagtctaat   1380

ctcaaacctt ttgagagaga tatttcaact gaaatctatc aggccggtag cacaccttgt   1440

aatggtgttg aaggttttaa ttgttacttt cctttacaat catatggttt ccaacccact   1500

aatggtgttg gttaccaacc atacagagta gtagtacttt cttttgaact tctacatgca   1560

ccagcaactg tttgtggacc taaaaagtct actaatttgg ttaaaaacaa atgtgtcaat   1620

ttcaacttca atggtttaac aggcacaggt gttcttactg agtctaacaa aaagtttctg   1680

cctttccaac aatttggcag agacattgct gacactactg atgctgtccg tgatccacag   1740

acacttgaga ttcttgacat tacaccatgt tcttttggtg gtgtcagtgt tataacacca   1800

ggaacaaata cttctaacca ggttgctgtt ctttatcagg atgttaactg cacagaagtc   1860

cctgttgcta ttcatgcaga tcaacttact cctacttggc gtgtttattc tacaggttct   1920

aatgtttttc aaacacgtgc aggctgttta ataggggctg aacatgtcaa caactcatat   1980

gagtgtgaca tacccattgg tgcaggtata tgcgctagtt atcagactca gactaattct   2040

cctcggcggg cacgtagtgt agctagtcaa tccatcattg cctacactat gtcacttggt   2100

gcagaaaatt cagttgctta ctctaataac tctattgcca tacccacaaa ttttactatt   2160

agtgttacca cagaaattct accagtgtct atgaccaaga catcagtaga ttgtacaatg   2220

tacatttgtg gtgattcaac tgaatgcagc aatcttttgt tgcaatatgg cagtttttgt   2280

acacaattaa accgtgcttt aactggaata gctgttgaac aagacaaaaa cacccaagaa   2340

gtttttgcac aagtcaaaca aatttacaaa acaccaccaa ttaaagattt tggtggtttt   2400

aatttttcac aaatattacc agatccatca aaaccaagca agaggtcatt tattgaagat   2460

ctacttttca acaaagtgac acttgcagat gctggcttca tcaaacaata tggtgattgc   2520

cttggtgata ttgctgctag agacctcatt tgtgcacaaa agtttaacgg ccttactgtt   2580

ttgccacctt tgctcacaga tgaaatgatt gctcaataca cttctgcact gttagcgggt   2640

acaatcactt ctggttggac ctttggtgca ggtgctgcat tacaaatacc atttgctatg   2700

caaatggctt ataggtttaa tggtattgga gttacacaga atgttctcta tgagaaccaa   2760

aaattgattg ccaaccaatt taatagtgct attggcaaaa ttcaagactc actttcttcc   2820

acagcaagtg cacttggaaa acttcaagat gtggtcaacc aaaatgcaca agctttaaac   2880

acgcttgtta aacaacttag ctccaatttt ggtgcaattt caagtgtttt aaatgatatc   2940

ctttcacgtc ttgacaaagt tgaggctgaa gtgcaaattg ataggttgat cacaggcaga   3000

cttcaaagtt tgcagacata tgtgactcaa caattaatta gagctgcaga aatcagagct   3060

tctgctaatc ttgctgctac taaaatgtca gagtgtgtac ttggacaatc aaaaagagtt   3120

gatttttgtg gaaagggcta tcatcttatg tccttccctc agtcagcacc tcatggtgta   3180

gtcttcttgc atgtgactta tgtccctgca caagaaaaga acttcacaac tgctcctgcc   3240

atttgtcatg atggaaaagc acactttcct cgtgaaggtg tctttgtttc aaatggcaca   3300

cactggtttg taacacaaag gaatttttat gaaccacaaa tcattactac agacaacaca   3360

tttgtgtctg gtaactgtga tgttgtaata ggaattgtca acaacacagt ttatgatcct   3420

ttgcaacctg aattagactc attcaaggag gagttagata aatattttaa gaatcataca   3480

tcaccagatg ttgatttagg tgacatctct ggcattaatg cttcagttgt aaacattcaa   3540

aaagaaattg accgcctcaa tgaggttgcc aagaatttaa atgaatctct catcgatctc   3600

caagaacttg gaaagtatga gcagtatata aaatggccat ggtacatttg gctaggtttt   3660

atagctggct tgattgccat agtaatggtg acaattatgc tttgctgtat gaccagttgc   3720

tgtagttgtc tcaagggctg ttgttcttgt ggatcctgct gcaaatttga tgaagacgac   3780

tctgagccag tgctcaaagg agtcaaatta cattacacat aa                      3822


<210>  22
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  22

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  23
<211>  1270
<212>  PRT
<213>  coronavirus

<400>  23

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  24
<211>  1270
<212>  PRT
<213>  coronavirus

<400>  24

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  25
<211>  1270
<212>  PRT
<213>  coronavirus

<400>  25

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala 
225                 230                 235                 240 


Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr 
                245                 250                 255     


Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe 
            260                 265                 270         


Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys 
        275                 280                 285             


Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr 
    290                 295                 300                 


Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr 
305                 310                 315                 320 


Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly 
                325                 330                 335     


Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg 
            340                 345                 350         


Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser 
        355                 360                 365             


Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu 
    370                 375                 380                 


Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg 
385                 390                 395                 400 


Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala 
                405                 410                 415     


Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala 
            420                 425                 430         


Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr 
        435                 440                 445             


Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp 
    450                 455                 460                 


Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val 
465                 470                 475                 480 


Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Pro Tyr Gly Phe Gln Pro 
                485                 490                 495     


Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe 
            500                 505                 510         


Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr 
        515                 520                 525             


Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr 
    530                 535                 540                 


Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln 
545                 550                 555                 560 


Gln Phe Gly Arg Asp Ile Asp Asp Thr Thr Asp Ala Val Arg Asp Pro 
                565                 570                 575     


Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val 
            580                 585                 590         


Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu 
        595                 600                 605             


Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp 
    610                 615                 620                 


Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe 
625                 630                 635                 640 


Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser 
                645                 650                 655     


Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln 
            660                 665                 670         


Thr Gln Thr Asn Ser His Arg Arg Ala Arg Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile Trp Leu  Gly Phe Ile 
    1205                 1210                 1215             


Ala Gly  Leu Ile Ala Ile Val  Met Val Thr Ile Met  Leu Cys Cys 
    1220                 1225                 1230             


Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly Cys Cys  Ser Cys Gly 
    1235                 1240                 1245             


Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser Glu Pro  Val Leu Lys 
    1250                 1255                 1260             


Gly Val  Lys Leu His Tyr Thr  
    1265                 1270 


<210>  26
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  26

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  27
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  27

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Thr Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  28
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  28

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  29
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  29

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  30
<211>  1273
<212>  PRT
<213>  coronavirus

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Cys Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Arg Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Gly Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  31
<211>  6
<212>  PRT
<213>  coronavirus

<400>  31

Gly Gln Gly Val Pro Ile 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  coronavirus

<400>  32

Arg Asn Leu Val Pro Ile 
1               5       


<210>  33
<211>  12
<212>  PRT
<213>  coronavirus

<400>  33

Pro Arg Trp Tyr Phe Tyr Tyr Leu Gly Thr Gly Pro 
1               5                   10          


<210>  34
<211>  12
<212>  PRT
<213>  coronavirus

<400>  34

Pro Lys Val His Phe Tyr Tyr Leu Gly Thr Gly Pro 
1               5                   10          


<210>  35
<211>  12
<212>  PRT
<213>  coronavirus

<400>  35

Pro Lys Leu His Phe Tyr Tyr Leu Gly Thr Gly Pro 
1               5                   10          


<210>  36
<211>  6
<212>  PRT
<213>  coronavirus

<400>  36

Lys Pro Arg Gln Lys Arg 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  coronavirus

<400>  37

Lys Pro Arg Trp Lys Arg 
1               5       


<210>  38
<211>  9
<212>  PRT
<213>  coronavirus

<400>  38

Arg Ser Ala Ile Glu Asp Leu Leu Phe 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  coronavirus

<400>  39

Arg Ser Phe Ile Glu Asp Leu Leu Phe 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  coronavirus

<400>  40

Arg Ser Phe Phe Glu Asp Leu Leu Phe 
1               5                   


<210>  41
<211>  6
<212>  PRT
<213>  coronavirus

<400>  41

Val Leu Pro Pro Leu Leu 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  coronavirus

<400>  42

Val Leu Pro Pro Ile Leu 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  coronavirus

<400>  43

Asn Gln Lys Leu Ile Ala 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  coronavirus

<400>  44

Ile Leu Ser Arg Leu Asp 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  coronavirus

<400>  45

Gln Ile Asp Arg Leu Ile 
1               5       


<210>  46
<211>  5
<212>  PRT
<213>  coronavirus

<400>  46

Lys Trp Pro Trp Tyr 
1               5   


<210>  47
<211>  10
<212>  PRT
<213>  coronavirus

<400>  47

Lys Val Asn Glu Cys Val Lys Ser Gln Ser 
1               5                   10  


<210>  48
<211>  5
<212>  PRT
<213>  coronavirus

<400>  48

Phe Cys Gly Asn Gly 
1               5   


<210>  49
<211>  8
<212>  PRT
<213>  coronavirus

<400>  49

Lys Trp Pro Trp Tyr Val Trp Leu 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  coronavirus

<400>  50

Lys Trp Pro Trp Trp Val Trp Leu 
1               5               


<210>  51
<211>  395
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  51

Met Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
1               5                   10                  15      


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
            20                  25                  30          


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
        35                  40                  45              


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
    50                  55                  60                  


Lys Phe Pro Arg Asn Thr Asn Ser Ser Pro Asp Asp Gln Ile Gly Tyr 
65                  70                  75                  80  


Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly Asp Gly Lys Met Lys 
                85                  90                  95      


Asp Leu Ser Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly Ile 
            100                 105                 110         


Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His Ile 
        115                 120                 125             


Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu Pro 
    130                 135                 140                 


Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg Gly 
145                 150                 155                 160 


Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser Ser 
                165                 170                 175     


Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg Met 
            180                 185                 190         


Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp Arg 
        195                 200                 205             


Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln Gln 
    210                 215                 220                 


Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Thr Ala 
225                 230                 235                 240 


Thr Lys Ala Tyr Asn Val Thr Gln Ala Phe Gly Arg Arg Gly Pro Glu 
                245                 250                 255     


Gln Thr Gln Gly Asn Phe Gly Asp Gln Glu Leu Ile Arg Gln Gly Thr 
            260                 265                 270         


Asp Tyr Lys His Trp Pro Gln Ile Ala Gln Phe Ala Pro Ser Ala Ser 
        275                 280                 285             


Ala Phe Phe Gly Met Ser Arg Ile Gly Met Glu Val Thr Pro Ser Gly 
    290                 295                 300                 


Thr Trp Leu Thr Tyr Thr Gly Ala Ile Lys Leu Asp Asp Lys Asp Pro 
305                 310                 315                 320 


Asn Phe Lys Asp Gln Val Ile Leu Leu Asn Lys His Ile Asp Ala Tyr 
                325                 330                 335     


Lys Thr Phe Pro Pro Thr Glu Pro Lys Lys Asp Lys Lys Lys Lys Ala 
            340                 345                 350         


Asp Glu Thr Gln Ala Leu Pro Gln Arg Gln Lys Lys Gln Gln Thr Val 
        355                 360                 365             


Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe Ser Lys Gln Leu Gln 
    370                 375                 380                 


Gln Ser Met Ser Ser Ala Asp Ser Thr Gln Ala 
385                 390                 395 


<210>  52
<211>  554
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  52
atgtccccta tactaggtta ttggaaaatt aagggccttg tgcaacccac tcgacttctt     60

ttggaatatc ttgaagaaaa atatgaagag catttgtatg agcgcgatga aggtgataaa    120

tggcgaaaca aaaagtttga attgggtttg gagtttccca atcttcctta ttatattgat    180

ggtgatgtta aattaacaca gtctatggcc atcatacgtt atatagctga caagcacaac    240

atgttgggtg gttgtccaaa agagcgtgca gagatttcaa tgcttgaagg agcggttttg    300

gatattagat acggtgtttc gagaattgca tatagtaaag actttgaaac tctcaaagtt    360

gattttctta gcaagctacc tgaaatgctg aaaatgttcg aagatcgttt atgtcataaa    420

acatatttaa atggtgatca tgtaacccat cctgacttca tgttgtatga cgctcttgat    480

gttgttttat acatggaccc aatgtgcctg gatgcgttcc caaaattagt ttgttttaaa    540

aaacgtattg aagc                                                      554


<210>  53
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  53

Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      


Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          


Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              


Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  


Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  


Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      


Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         


Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             


Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 


Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 


Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     


Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         


Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             


Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
    210                 215             


<210>  54
<211>  18
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  54
catcaccatc accatcac                                                   18


<210>  55
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  55

His His His His His His 
1               5       


<210>  56
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  56

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  57
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  57

Tyr Pro Tyr Asp Tyr Pro Asp Tyr Ala 
1               5                   


<210>  58
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  58

Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu 
1               5                   10  


<210>  59
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  59

Ser Arg Leu Glu Glu Glu Leu Arg Arg Arg Leu Thr Glu 
1               5                   10              


<210>  60
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  60

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  61
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  61

Pro Asp Arg Val Arg Ala Val Ser His Trp Ser Ser 
1               5                   10          


<210>  62
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  62

Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly 
1               5                   10      


<210>  63
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  63

Thr Lys Glu Asn Pro Arg Ser Asn Gln Glu Phe Ser Tyr Asp Asp Asn 
1               5                   10                  15      


Glu Ser 
        


