                         SEQUENCE LISTING

<110>  New York University
       Alberini, Cristina Maria
       Cruz, Emmanuel
 
<120>  Use of IGF-2 for Treatment of Epileptic Seizures

<130>  RTTP-006/01WO

<150>  63,015,181
<151>  2020-04-24

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ile Pro Met Gly Lys Ser Met Leu Val Leu Leu Thr Phe Leu 
1               5                   10                  15      


Ala Phe Ala Ser Cys Cys Ile Ala Ala Tyr Arg Pro Ser Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Gly Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ala Ser Arg Val Ser Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Pro Pro Thr Val Leu Pro Asp Asn Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Lys Gln Ser Thr Gln Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly His Val Leu Ala Lys 
    130                 135                 140                 


Glu Leu Glu Ala Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Ala 
145                 150                 155                 160 


Leu Pro Thr Gln Asp Pro Ala His Gly Gly Ala Pro Pro Glu Met Ala 
                165                 170                 175     


Ser Asn Arg Lys 
            180 


<210>  2
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  2
atgggaatcc caatggggaa gtcgatgctg gtgcttctca ccttcttggc cttcgcctcg       60

tgctgcattg ctgcttaccg ccccagtgag accctgtgcg gcggggagct ggtggacacc      120

ctccagttcg tctgtgggga ccgcggcttc tacttcagca ggcccgcaag ccgtgtgagc      180

cgtcgcagcc gtggcatcgt tgaggagtgc tgtttccgca gctgtgacct ggccctcctg      240

gagacgtact gtgctacccc cgccaagtcc gagagggacg tgtcgacccc tccgaccgtg      300

cttccggaca acttccccag ataccccgtg ggcaagttct tccaatatga cacctggaag      360

cagtccaccc agcgcctgcg caggggcctg cctgccctcc tgcgtgcccg ccggggtcac      420

gtgctcgcca aggagctcga ggcgttcagg gaggccaaac gtcaccgtcc cctgattgct      480

ctacccaccc aagaccccgc ccacgggggc gcccccccag agatggccag caatcggaag      540


<210>  3
<211>  236
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Val Ser Pro Asp Pro Gln Ile Ile Val Val Ala Pro Glu Thr Glu 
1               5                   10                  15      


Leu Ala Ser Met Gln Val Gln Arg Thr Glu Asp Gly Val Thr Ile Ile 
            20                  25                  30          


Gln Ile Phe Trp Val Gly Arg Lys Gly Glu Leu Leu Arg Arg Thr Pro 
        35                  40                  45              


Val Ser Ser Ala Met Gln Thr Pro Met Gly Ile Pro Met Gly Lys Ser 
    50                  55                  60                  


Met Leu Val Leu Leu Thr Phe Leu Ala Phe Ala Ser Cys Cys Ile Ala 
65                  70                  75                  80  


Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
                85                  90                  95      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            100                 105                 110         


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        115                 120                 125             


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    130                 135                 140                 


Lys Ser Glu Arg Asp Val Ser Thr Pro Pro Thr Val Leu Pro Asp Asn 
145                 150                 155                 160 


Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp Thr Trp Lys 
                165                 170                 175     


Gln Ser Thr Gln Arg Leu Arg Arg Gly Leu Pro Ala Leu Leu Arg Ala 
            180                 185                 190         


Arg Arg Gly His Val Leu Ala Lys Glu Leu Glu Ala Phe Arg Glu Ala 
        195                 200                 205             


Lys Arg His Arg Pro Leu Ile Ala Leu Pro Thr Gln Asp Pro Ala His 
    210                 215                 220                 


Gly Gly Ala Pro Pro Glu Met Ala Ser Asn Arg Lys 
225                 230                 235     


<210>  4
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  4
atgggaatcc caatggggaa gtcgatgctg gtgcttctca ccttcttggc cttcgcctcg       60

tgctgcattg ctgcttaccg ccccagtgag accctgtgcg gcggggagct ggtggacacc      120

ctccagttcg tctgtgggga ccgcggcttc tacttcagca ggcccgcaag ccgtgtgagc      180

cgtcgcagcc gtggcatcgt tgaggagtgc tgtttccgca gctgtgacct ggccctcctg      240

gagacgtact gtgctacccc cgccaagtcc gagagggacg tgtcgacccc tccgaccgtg      300

cttccggaca acttccccag ataccccgtg ggcaagttct tccaatatga cacctggaag      360

cagtccaccc agcgcctgcg caggggcctg cctgccctcc tgcgtgcccg ccggggtcac      420

gtgctcgcca aggagctcga ggcgttcagg gaggccaaac gtcaccgtcc cctgattgct      480

ctacccaccc aagaccccgc ccacgggggc gcccccccag agatggccag caatcggaag      540


<210>  5
<211>  57
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu 
    50                  55          


<210>  6
<211>  171
<212>  DNA
<213>  Homo sapiens

<400>  6
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga g               171


<210>  7
<211>  191
<212>  PRT
<213>  Mus musculus

<400>  7

Met Gly Gly Ser Val Ala Gly Phe Gln Val Pro Met Gly Ile Pro Val 
1               5                   10                  15      


Gly Lys Ser Met Leu Val Leu Leu Ile Ser Leu Ala Phe Ala Leu Cys 
            20                  25                  30          


Cys Ile Ala Ala Tyr Gly Pro Gly Glu Thr Leu Cys Gly Gly Glu Leu 
        35                  40                  45              


Val Asp Thr Leu Gln Phe Val Cys Ser Asp Arg Gly Phe Tyr Phe Ser 
    50                  55                  60                  


Arg Pro Ser Ser Arg Ala Asn Arg Arg Ser Arg Gly Ile Val Glu Glu 
65                  70                  75                  80  


Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala 
                85                  90                  95      


Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr Ser Gln Ala Val Leu 
            100                 105                 110         


Pro Asp Asp Phe Pro Arg Tyr Pro Val Gly Lys Phe Phe Gln Tyr Asp 
        115                 120                 125             


Thr Trp Arg Gln Ser Ala Gly Arg Leu Arg Arg Gly Leu Pro Ala Leu 
    130                 135                 140                 


Leu Arg Ala Arg Arg Gly Arg Met Leu Ala Lys Glu Leu Lys Glu Phe 
145                 150                 155                 160 


Arg Glu Ala Lys Arg His Arg Pro Leu Ile Val Leu Pro Pro Lys Asp 
                165                 170                 175     


Pro Ala His Gly Gly Ala Ser Ser Glu Met Ser Ser Asn His Gln 
            180                 185                 190     


<210>  8
<211>  573
<212>  DNA
<213>  Mus musculus

<400>  8
atgggcggca gcgtcgccgg cttccaggta ccaatgggga tcccagtggg gaagtcgatg       60

ttggtgcttc tcatctcttt ggccttcgcc ttgtgctgca tcgctgctta cggccccgga      120

gagactctgt gcggagggga gcttgttgac acgcttcagt ttgtctgttc ggaccgcggc      180

ttctacttca gcaggccttc aagccgtgcc aaccgtcgca gccgtggcat cgtggaagag      240

tgctgcttcc gcagctgcga cctggccctc ctggagacat actgtgccac ccccgccaag      300

tccgagaggg acgtgtctac ctctcaggcc gtacttccgg acgacttccc cagatacccc      360

gtgggcaagt tcttccaata tgacacctgg agacagtccg cgggacgcct gcgcagaggc      420

ctgcctgccc tcctgcgtgc ccgccggggt cgcatgcttg ccaaagagct caaagagttc      480

agagaggcca aacgtcatcg tcccctgatc gtgttaccac ccaaagaccc cgcccacggg      540

ggagcctctt cggagatgtc cagcaaccat cag                                   573


<210>  9
<211>  180
<212>  PRT
<213>  Mus musculus

<400>  9

Met Gly Ile Pro Val Gly Lys Ser Met Leu Val Leu Leu Ile Ser Leu 
1               5                   10                  15      


Ala Phe Ala Leu Cys Cys Ile Ala Ala Tyr Gly Pro Gly Glu Thr Leu 
            20                  25                  30          


Cys Gly Gly Glu Leu Val Asp Thr Leu Gln Phe Val Cys Ser Asp Arg 
        35                  40                  45              


Gly Phe Tyr Phe Ser Arg Pro Ser Ser Arg Ala Asn Arg Arg Ser Arg 
    50                  55                  60                  


Gly Ile Val Glu Glu Cys Cys Phe Arg Ser Cys Asp Leu Ala Leu Leu 
65                  70                  75                  80  


Glu Thr Tyr Cys Ala Thr Pro Ala Lys Ser Glu Arg Asp Val Ser Thr 
                85                  90                  95      


Ser Gln Ala Val Leu Pro Asp Asp Phe Pro Arg Tyr Pro Val Gly Lys 
            100                 105                 110         


Phe Phe Gln Tyr Asp Thr Trp Arg Gln Ser Ala Gly Arg Leu Arg Arg 
        115                 120                 125             


Gly Leu Pro Ala Leu Leu Arg Ala Arg Arg Gly Arg Met Leu Ala Lys 
    130                 135                 140                 


Glu Leu Lys Glu Phe Arg Glu Ala Lys Arg His Arg Pro Leu Ile Val 
145                 150                 155                 160 


Leu Pro Pro Lys Asp Pro Ala His Gly Gly Ala Ser Ser Glu Met Ser 
                165                 170                 175     


Ser Asn His Gln 
            180 


<210>  10
<211>  540
<212>  DNA
<213>  Mus musculus

<400>  10
atggggatcc cagtggggaa gtcgatgttg gtgcttctca tctctttggc cttcgccttg       60

tgctgcatcg ctgcttacgg ccccggagag actctgtgcg gaggggagct tgttgacacg      120

cttcagtttg tctgttcgga ccgcggcttc tacttcagca ggccttcaag ccgtgccaac      180

cgtcgcagcc gtggcatcgt ggaagagtgc tgcttccgca gctgcgacct ggccctcctg      240

gagacatact gtgccacccc cgccaagtcc gagagggacg tgtctacctc tcaggccgta      300

cttccggacg acttccccag ataccccgtg ggcaagttct tccaatatga cacctggaga      360

cagtccgcgg gacgcctgcg cagaggcctg cctgccctcc tgcgtgcccg ccggggtcgc      420

atgcttgcca aagagctcaa agagttcaga gaggccaaac gtcatcgtcc cctgatcgtg      480

ttaccaccca aagaccccgc ccacggggga gcctcttcgg agatgtccag caaccatcag      540


<210>  11
<211>  67
<212>  PRT
<213>  Mus musculus

<400>  11

Ala Tyr Gly Pro Gly Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Ser Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ser 
            20                  25                  30          


Ser Arg Ala Asn Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  12
<211>  201
<212>  DNA
<213>  Mus musculus

<400>  12
gcttacggcc ccggagagac tctgtgcgga ggggagcttg ttgacacgct tcagtttgtc       60

tgttcggacc gcggcttcta cttcagcagg ccttcaagcc gtgccaaccg tcgcagccgt      120

ggcatcgtgg aagagtgctg cttccgcagc tgcgacctgg ccctcctgga gacatactgt      180

gccacccccg ccaagtccga g                                                201


<210>  13
<211>  67
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Tyr Arg Pro Ser Glu Thr Leu Cys Gly Gly Glu Leu Val Asp Thr 
1               5                   10                  15      


Leu Gln Phe Val Cys Gly Asp Arg Gly Phe Tyr Phe Ser Arg Pro Ala 
            20                  25                  30          


Ser Arg Val Ser Arg Arg Ser Arg Gly Ile Val Glu Glu Cys Cys Phe 
        35                  40                  45              


Arg Ser Cys Asp Leu Ala Leu Leu Glu Thr Tyr Cys Ala Thr Pro Ala 
    50                  55                  60                  


Lys Ser Glu 
65          


<210>  14
<211>  201
<212>  DNA
<213>  Homo sapiens

<400>  14
gcttaccgcc ccagtgagac cctgtgcggc ggggagctgg tggacaccct ccagttcgtc       60

tgtggggacc gcggcttcta cttcagcagg cccgcaagcc gtgtgagccg tcgcagccgt      120

ggcatcgttg aggagtgctg tttccgcagc tgtgacctgg ccctcctgga gacgtactgt      180

gctacccccg ccaagtccga g                                                201


