                         SEQUENCE LISTING

<110>  University of Miami
 
<120>  METHODS AND COMPOSITIONS FOR TREATING VIRUS-ASSOCIATED INFLAMMATION

<130>  UNMI-010/05WO 316457-2114

<150>  US 16/856,407
<151>  2020-04-23

<150>  US 16/026,482
<151>  2018-07-03

<150>  PCT/US2017/068713
<151>  2017-12-28

<150>  US 62/440,180
<151>  2016-12-29

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  1

Ala Leu Arg Gln Thr Gln Pro Tyr Leu Val Thr Asp Leu Glu Gln Ser 
1               5                   10                  15      


<210>  2
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Glu Ser Gln Ser Tyr Leu Val Glu Asp Leu Glu Arg Ser 
1               5                   10                  


<210>  3
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Glu Tyr Tyr Thr Glu Ile Arg Glu Arg Glu Arg Glu Lys Ser Glu 
1               5                   10                  15      


Lys Gly Arg 
            


<210>  4
<211>  15
<212>  PRT
<213>  Rattus norvegicus

<400>  4

Met Glu Glu Ser Gln Ser Lys Glu Glu Ser Asn Thr Glu Gly Cys 
1               5                   10                  15  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  antigenic fragment of caspase activating recruitment domain (ASC)

<400>  5

Lys Lys Phe Lys Leu Lys Leu Leu Ser Val Pro Leu Arg Glu Gly Tyr 
1               5                   10                  15      


Gly Arg Ile Pro Arg 
            20      


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Amino Acid Sequence

<400>  6

Thr Ser Gly Met Gly Val Ser 
1               5           


<210>  7
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Amino Acid Sequence

<400>  7

His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  8
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 Amino Acid Sequence

<400>  8

Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr 
1               5                   10      


<210>  9
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR1 Nucleic Acid Sequence

<400>  9
actagtggaa tgggtgtgag c                                                 21


<210>  10
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR2 Nucleic Acid Sequence

<400>  10
cacatttatt gggatgatga taagcgctac aacccatctc tgaagagc                    48


<210>  11
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain CDR3 Nucleic Acid Sequence

<400>  11
agcaccccca tcgtggccaa cgccatggac tac                                    33


<210>  12
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR1 Amino Acid Sequence

<400>  12

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  13
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR2 Amino Acid Sequence

<400>  13

Ala Ala Ser Asn Leu Glu Ser 
1               5           


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR3 Amino Acid Sequence

<400>  14

Gln Gln Ser Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR1 Nucleic Acid Sequence

<400>  15
aaggccagcc agagtgttga ctacgacggc gacagttaca tgaat                       45


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR2 Nucleic Acid Sequence

<400>  16
gccgcatcta acctggaatc c                                                 21


<210>  17
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light (Kappa) Chain CDR3 Nucleic Acid Sequence

<400>  17
cagcaatcta atgaggaccc ttacact                                           27


<210>  18
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH1 Heavy Chain Sequence

<400>  18

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Ile Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Lys Ile Thr Ser Val Asp Pro Val Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  19
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH2 Heavy Chain Sequence

<400>  19

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  20
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH3 Heavy Chain Sequence

<400>  20

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  21
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH4 Heavy Chain Sequence

<400>  21

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ala Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  22
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH0 (Chimeric) Heavy Chain

<400>  22

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Ser Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Tyr Trp Asp Asp Asp Lys Arg Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Ser Ser Ser Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Val Asp Thr Ala Asp Thr Ala Thr Tyr Ser 
                85                  90                  95      


Cys Ala Arg Ser Thr Pro Ile Val Ala Asn Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  23
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH1 Heavy Chain Sequence

<400>  23
caggtcacct tgaaggagtc tggtcctgcc atcgtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagccctcag gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttaaaa tcaccagcgt ggaccctgtg gacacagcca catattcctg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccagcgt caccgtctcc      360

tca                                                                    363


<210>  24
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH2 Heavy Chain Sequence

<400>  24
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattcctg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  25
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH3 Heavy Chain Sequence

<400>  25
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcagct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acagctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  26
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH4 Heavy Chain Sequence

<400>  26
caggtcacct tgaaggagtc tggtcctgcc ctggtgaaac ccacacagac cctcacgctg       60

acctgcacct tctctgggtt ctcactcagc actagtggaa tgggtgtgag ctggatccgt      120

cagcccgccg gaaagggcct ggagtggctt gcacacattt attgggatga tgataagcgc      180

tacaacccat ctctgaagag caggctcacc atctccaagg acacctccaa aaaccaggtg      240

gtccttacaa tgaccaacat ggaccctgtg gacacagcca catattactg tgcacggagc      300

acccccatcg tggccaacgc catggactac tggggccaag gaaccctggt caccgtctcc      360

tca                                                                    363


<210>  27
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VH0 (Chimeric) Heavy Chain

<400>  27
caggttactc tgaaagagtc tggccctggg atattgcagc cctcccagac cctcagtctg       60

acttgttctt tctctgggtt ttcactgagc acttctggta tgggtgtgag ctggattcgt      120

cagccttcag gaaagggtct ggagtggctg gcacacattt actgggatga tgacaagcgc      180

tataacccat ccctgaagag ccggctcaca atctccaagg attcctccag caaccaggtc      240

ttcctcaaga tcaccagtgt ggacactgca gatactgcca catactcctg tgctcgaagt      300

actccgattg tagctaatgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL1 Light Chain Sequence

<400>  28

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Glu Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL2 Light Chain Sequence

<400>  29

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL3 Light Chain Sequence

<400>  30

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VLO Chimeric Light Chain Sequence

<400>  31

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp Tyr Asp 
            20                  25                  30          


Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  32
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL1 Light Chain Sequence

<400>  32
gacatcgtgc tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagg aggaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  33
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL2 Light Chain Sequence

<400>  33
gacatcgtgc tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagc ctgaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  34
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VL3 Light Chain Sequence

<400>  34
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gagggccacc       60

atcaactgca aggccagcca gagtgttgac tacgacggcg acagttacat gaattggtac      120

cagcagaaac caggacagcc tcctaagctg ctcatttacg ccgcatctaa cctggaatcc      180

ggcatccctg cccgattcag tggcagcggg tctgggacag atttcactct caccatcagc      240

agcctgcagc ctgaagatgt ggcaacttat tactgtcagc aatctaatga ggacccttac      300

acttttggcc aggggaccaa gctggagatc aaa                                   333


<210>  35
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VLO Chimeric Light Chain Sequence

<400>  35
gacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atctcctgca aggccagcca aagtgttgat tatgatggtg atagttatat gaactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatg ctgcatccaa tctagaatct      180

ggcatcccag ccaggtttag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc aaagtaatga ggacccgtac      300

acgttcggag gggggaccaa gctggaaata aaa                                   333


