                         SEQUENCE LISTING

<110>  Emory University
 
<120>  Coronavirus Vaccines, Compositions, and  Methods Related Thereto

<130>  20121 PCT

<150>  US 63/012,920
<151>  2020-04-21

<150>  US 63/044,711
<151>  2020-06-26

<150>  US 63/084,065
<151>  2020-09-28

<150>  US 63/143,191
<151>  2021-01-29

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
            980                 985         


<210>  2
<211>  1273
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  3
<211>  1614
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  3

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr Gly Ser  Gly Ala Thr 
    1265                 1270                 1275             


Asn Phe  Ser Leu Leu Lys Gln  Ala Gly Asp Val Glu  Glu Asn Pro 
    1280                 1285                 1290             


Gly Pro  Met Ala Asp Ser Asn  Gly Thr Ile Thr Val  Glu Glu Leu 
    1295                 1300                 1305             


Lys Lys  Leu Leu Glu Gln Trp  Asn Leu Val Ile Gly  Phe Leu Phe 
    1310                 1315                 1320             


Leu Thr  Trp Ile Cys Leu Leu  Gln Phe Ala Tyr Ala  Asn Arg Asn 
    1325                 1330                 1335             


Arg Phe  Leu Tyr Ile Ile Lys  Leu Ile Phe Leu Trp  Leu Leu Trp 
    1340                 1345                 1350             


Pro Val  Thr Leu Ala Cys Phe  Val Leu Ala Ala Val  Tyr Arg Ile 
    1355                 1360                 1365             


Asn Trp  Ile Thr Gly Gly Ile  Ala Ile Ala Met Ala  Cys Leu Val 
    1370                 1375                 1380             


Gly Leu  Met Trp Leu Ser Tyr  Phe Ile Ala Ser Phe  Arg Leu Phe 
    1385                 1390                 1395             


Ala Arg  Thr Arg Ser Met Trp  Ser Phe Asn Pro Glu  Thr Asn Ile 
    1400                 1405                 1410             


Leu Leu  Asn Val Pro Leu His  Gly Thr Ile Leu Thr  Arg Pro Leu 
    1415                 1420                 1425             


Leu Glu  Ser Glu Leu Val Ile  Gly Ala Val Ile Leu  Arg Gly His 
    1430                 1435                 1440             


Leu Arg  Ile Ala Gly His His  Leu Gly Arg Cys Asp  Ile Lys Asp 
    1445                 1450                 1455             


Leu Pro  Lys Glu Ile Thr Val  Ala Thr Ser Arg Thr  Leu Ser Tyr 
    1460                 1465                 1470             


Tyr Lys  Leu Gly Ala Ser Gln  Arg Val Ala Gly Asp  Ser Gly Phe 
    1475                 1480                 1485             


Ala Ala  Tyr Ser Arg Tyr Arg  Ile Gly Asn Tyr Lys  Leu Asn Thr 
    1490                 1495                 1500             


Asp His  Ser Ser Ser Ser Asp  Asn Ile Ala Leu Leu  Val Gln Gly 
    1505                 1510                 1515             


Ser Gly  Ala Thr Asn Phe Ser  Leu Leu Lys Gln Ala  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Asn Pro Gly Pro Met  Tyr Ser Phe Val Ser  Glu Glu Thr 
    1535                 1540                 1545             


Gly Thr  Leu Ile Val Asn Ser  Val Leu Leu Phe Leu  Ala Phe Val 
    1550                 1555                 1560             


Val Phe  Leu Leu Val Thr Leu  Ala Ile Leu Thr Ala  Leu Arg Leu 
    1565                 1570                 1575             


Cys Ala  Tyr Cys Cys Asn Ile  Val Asn Val Ser Leu  Val Lys Pro 
    1580                 1585                 1590             


Ser Phe  Tyr Val Tyr Ser Arg  Val Lys Asn Leu Asn  Ser Ser Arg 
    1595                 1600                 1605             


Val Pro  Asp Leu Leu Val 
    1610                 


<210>  4
<211>  2973
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  4
atgtggttac aaggactact attactaggt actgttgcct gttcaatttc acaatgtgta       60

aatctaacta caagaactca attaccgcct gcctatacta attcttttac aagaggagta      120

tattatcctg ataaagtttt tagatcttct gtattacatt ctacacaaga tttgttttta      180

ccatttttct ctaatgttac ttggtttcat gcaatacatg tatctggaac taatggaaca      240

aaaagatttg ataatccagt attacctttt aatgatggag tttattttgc ttctactgaa      300

aaatctaata taattagagg atggatattt ggaactacat tagattctaa aacacaatct      360

ctactaattg ttaataatgc aactaatgta gttataaaag tatgtgaatt tcaattttgt      420

aatgatccat ttttgggagt ttattatcat aaaaataata agtcttggat ggaatctgaa      480

ttcagagtat attcttctgc taataattgt acatttgaat atgtatctca accatttttg      540

atggatttgg aaggaaaaca aggaaacttt aaaaatttga gagaatttgt ttttaaaaat      600

attgatggat actttaaaat ctattctaaa catactccaa ttaatctagt aagagatttg      660

cctcaaggat tttctgcttt agaaccacta gtagatttgc ctataggaat taatattact      720

agatttcaaa cattattagc tttacataga tcttatttga cacctggaga ttcttcttct      780

ggatggactg caggagctgc agcttattat gttggatatt tgcaaccaag aacatttttg      840

ttaaaatata atgaaaatgg aactataaca gatgcagttg attgtgcttt agatcctcta      900

tctgaaacta aatgtacttt aaaatctttt actgtagaaa aaggaatcta tcaaacatct      960

aactttagag tacaaccaac tgaatctatt gttagatttc caaatataac aaatctatgt     1020

ccttttggag aagtttttaa tgcaactaga tttgcttctg tatatgcatg gaatagaaaa     1080

agaatatcta attgcgtagc tgattattct gtattatata attctgcatc tttttctact     1140

tttaaatgtt atggagtatc tccaacaaaa ttgaatgatc tatgttttac taatgtttat     1200

gcagattctt ttgtaataag aggagatgaa gttagacaaa tagctcctgg acaaacagga     1260

aaaatagcag attataatta taaattacca gatgatttca ctggatgcgt aattgcttgg     1320

aattctaata atttggattc taaagtagga ggaaattata attatttgta tagattgttt     1380

agaaaatcta atttgaaacc ttttgaaaga gatatttcta cagaaatcta tcaagcagga     1440

tctactccat gtaatggagt tgaaggtttt aattgttatt ttccactaca atcttatgga     1500

tttcaaccta caaatggagt aggatatcaa ccatatagag tagttgtatt atcttttgaa     1560

ttattacatg caccagctac agtatgtgga cctaaaaaat ctactaattt ggttaaaaat     1620

aagtgcgtaa actttaactt taatggatta actggaacag gagttttaac tgaatctaat     1680

aagaaatttt tgccttttca acaatttgga agagatattg ctgatactac agatgcagta     1740

agagatcctc aaactttaga aatattggat attacaccat gttcttttgg aggagtttct     1800

gtaataacac caggaactaa tacatctaat caagttgctg tattatatca agatgttaat     1860

tgtactgaag ttcctgtagc aattcatgct gatcaattaa ctccaacatg gagagtatat     1920

tctactggat ctaatgtttt tcaaacaaga gctggatgtc taattggagc agaacatgta     1980

aataattctt atgaatgtga tattcctata ggagctggaa tatgtgcatc ttatcaaact     2040

caaacaaatt ctccaagaag agctagatct gttgcatctc aatctataat tgcttataca     2100

atgtctttag gagctgaaaa ttctgtagca tattctaata attctattgc aattcctact     2160

aactttacta tttctgtaac tacagaaata ttgccagttt ctatgactaa aacatctgta     2220

gattgtacaa tgtatatatg tggagattct actgaatgtt ctaatttgct actacaatat     2280

ggatcttttt gtactcaatt gaatagagct ttaacaggaa tagcagtaga acaagataaa     2340

aatacacaag aagtttttgc tcaagtaaaa caaatctata aaactccacc tataaaagat     2400

tttggaggtt ttaatttttc tcaaatattg ccagatcctt ctaaaccttc taaaagatct     2460

tttattgaag atttgttgtt taataaggtt acattagcag atgctggttt tataaaacaa     2520

tatggagatt gtttaggaga tattgcagct agagatttga tttgtgctca aaagtttaat     2580

ggattaactg tattaccacc tctactaaca gatgaaatga tagcacaata tacatctgca     2640

ttattagctg gaactattac atctggatgg acttttggag ctggagcagc tttacaaata     2700

ccatttgcta tgcaaatggc atatagattc aatggaattg gagttactca aaatgtatta     2760

tatgaaaatc aaaaactaat tgctaatcaa ttcaattctg caattggaaa aattcaagat     2820

tctctatctt ctacagcatc tgctttagga aaactacaag atgttgtaaa tcaaaatgca     2880

caagctttaa atactctagt taaacaacta tcttctaatt ttggagctat ttcttctgtt     2940

ttaaatgata tattgtctag actagatcca cct                                  2973


<210>  5
<211>  9903
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  5
gaattccctg ggacatacgt atatttctat gatctgtctt atatgaagtc tatacagcga       60

atagattcag aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc      120

cccgaagatt tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat      180

atagactcgt tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg      240

aagatgatag agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat      300

aattttgaga ggacgggaga attaactagt attgtacaag aagccatttt atctctaaat      360

ttacgaatta agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt      420

aaaatattat tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta      480

acgggatata tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaggc      540

gcgcctttca ttttgttttt ttctatgcta taaatggtga gcaagggcga ggagctgttc      600

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      660

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc      720

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg      780

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      840

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      900

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      960

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1020

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     1080

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     1140

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     1200

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     1260

atcactctcg gcatgcacga gctgtacaag taagagctcg aggacgggag aattaactag     1320

tattgtacaa gaagccattt tatctctaaa tttacgaatt aagattttaa attttaaaca     1380

taaagatgat gatacgtata tacacttttg taaaatatta ttcggtgtct ataacggaac     1440

aaacgctact atatattatc atagacctct aacgggatat atgaatatga tttcagatac     1500

tatatttgtt cctgtagata ataactaact cgaggccgct ggtacccaac ctaaaaattg     1560

aaaataaata caaaggttct tgagggttgt gttaaattga aagcgagaaa taatcataaa     1620

taagcccggg accatgtttg tttttctagt tttgctaccg ttggtttcaa gtcaatgtgt     1680

aaatctaact acaagaactc aattaccgcc tgcctatact aattctttta caagaggagt     1740

atattatcct gataaagttt ttagatcttc tgtattacat tctacacaag atttgttttt     1800

accatttttc tctaatgtta cttggtttca tgcaatacat gtatctggaa ctaatggaac     1860

aaaaagattt gataatccag tattaccttt taatgatgga gtttattttg cttctactga     1920

aaaatctaat ataattagag gatggatatt tggaactaca ttagattcta aaacacaatc     1980

tctactaatt gttaataatg caactaatgt agttataaaa gtatgtgaat ttcaattttg     2040

taatgatcca tttttgggag tttattatca taaaaataat aagtcttgga tggaatctga     2100

attcagagta tattcttctg ctaataattg tacatttgaa tatgtatctc aaccattttt     2160

gatggatttg gaaggaaaac aaggaaactt taaaaatttg agagaatttg tttttaaaaa     2220

tattgatgga tactttaaaa tctattctaa acatactcca attaatctag taagagattt     2280

gcctcaagga ttttctgctt tagaaccact agtagatttg cctataggaa ttaatattac     2340

tagatttcaa acattattag ctttacatag atcttatttg acacctggag attcttcttc     2400

tggatggact gcaggagctg cagcttatta tgttggatat ttgcaaccaa gaacattttt     2460

gttaaaatat aatgaaaatg gaactataac agatgcagtt gattgtgctt tagatcctct     2520

atctgaaact aaatgtactt taaaatcttt tactgtagaa aaaggaatct atcaaacatc     2580

taactttaga gtacaaccaa ctgaatctat tgttagattt ccaaatataa caaatctatg     2640

tccttttgga gaagttttta atgcaactag atttgcttct gtatatgcat ggaatagaaa     2700

aagaatatct aattgcgtag ctgattattc tgtattatat aattctgcat ctttttctac     2760

ttttaaatgt tatggagtat ctccaacaaa attgaatgat ctatgtttta ctaatgttta     2820

tgcagattct tttgtaataa gaggagatga agttagacaa atagctcctg gacaaacagg     2880

aaaaatagca gattataatt ataaattacc agatgatttc actggatgcg taattgcttg     2940

gaattctaat aatttggatt ctaaagtagg aggaaattat aattatttgt atagattgtt     3000

tagaaaatct aatttgaaac cttttgaaag agatatttct acagaaatct atcaagcagg     3060

atctactcca tgtaatggag ttgaaggttt taattgttat tttccactac aatcttatgg     3120

atttcaacct acaaatggag taggatatca accatataga gtagttgtat tatcttttga     3180

attattacat gcaccagcta cagtatgtgg acctaaaaaa tctactaatt tggttaaaaa     3240

taagtgcgta aactttaact ttaatggatt aactggaaca ggagttttaa ctgaatctaa     3300

taagaaattt ttgccttttc aacaatttgg aagagatatt gctgatacta cagatgcagt     3360

aagagatcct caaactttag aaatattgga tattacacca tgttcttttg gaggagtttc     3420

tgtaataaca ccaggaacta atacatctaa tcaagttgct gtattatatc aagatgttaa     3480

ttgtactgaa gttcctgtag caattcatgc tgatcaatta actccaacat ggagagtata     3540

ttctactgga tctaatgttt ttcaaacaag agctggatgt ctaattggag cagaacatgt     3600

aaataattct tatgaatgtg atattcctat aggagctgga atatgtgcat cttatcaaac     3660

tcaaacaaat tctccaagaa gagctagatc tgttgcatct caatctataa ttgcttatac     3720

aatgtcttta ggagctgaaa attctgtagc atattctaat aattctattg caattcctac     3780

taactttact atttctgtaa ctacagaaat attgccagtt tctatgacta aaacatctgt     3840

agattgtaca atgtatatat gtggagattc tactgaatgt tctaatttgc tactacaata     3900

tggatctttt tgtactcaat tgaatagagc tttaacagga atagcagtag aacaagataa     3960

aaatacacaa gaagtttttg ctcaagtaaa acaaatctat aaaactccac ctataaaaga     4020

ttttggaggt tttaattttt ctcaaatatt gccagatcct tctaaacctt ctaaaagatc     4080

ttttattgaa gatttgttgt ttaataaggt tacattagca gatgctggtt ttataaaaca     4140

atatggagat tgtttaggag atattgcagc tagagatttg atttgtgctc aaaagtttaa     4200

tggattaact gtattaccac ctctactaac agatgaaatg atagcacaat atacatctgc     4260

attattagct ggaactatta catctggatg gacttttgga gctggagcag ctttacaaat     4320

accatttgct atgcaaatgg catatagatt caatggaatt ggagttactc aaaatgtatt     4380

atatgaaaat caaaaactaa ttgctaatca attcaattct gcaattggaa aaattcaaga     4440

ttctctatct tctacagcat ctgctttagg aaaactacaa gatgttgtaa atcaaaatgc     4500

acaagcttta aatactctag ttaaacaact atcttctaat tttggagcta tttcttctgt     4560

tttaaatgat atattgtcta gactagatcc acctgaagca gaagtacaaa ttgatagact     4620

aattacagga agattacaat ctctacaaac ttatgtaaca caacaactaa ttagagcagc     4680

tgaaataaga gcatctgcta atttggcagc tactaaaatg tctgaatgcg tattaggaca     4740

atctaaaaga gtagattttt gtggaaaagg atatcatttg atgtcttttc cacaatctgc     4800

tcctcatgga gtagtatttt tgcatgttac atatgtacct gcacaagaaa agaactttac     4860

tacagcacca gctatatgtc atgatggaaa agctcatttt cctagagaag gagtttttgt     4920

atctaatgga actcattggt ttgttacaca aagaaacttt tatgaaccac aaattataac     4980

tacagataat acatttgtat ctggaaattg tgatgttgta attggaattg ttaataatac     5040

tgtatatgat ccactacaac ctgaactaga ttcttttaaa gaagaactag ataaatactt     5100

taaaaatcat acttctcctg atgttgattt gggagatata tctggaatta atgcttctgt     5160

tgtaaatatt caaaaagaaa tagatagatt gaatgaagta gcaaaaaatt tgaatgaatc     5220

tctaattgat ttgcaagaat taggaaaata tgaacaatat atcaaatggc catggtatat     5280

ttggctaggt tttatagctg gattaatagc aattgttatg gtaactatta tgttatgttg     5340

tatgacatct tgttgttctt gtctaaaagg atgttgttct tgtggatctt gttgtaaatt     5400

tgatgaagat gattctgaac ctgttttgaa aggtgttaaa ctacattata ctggatctgg     5460

agcaactaat ttttctttgt taaaacaagc tggagatgta gaagaaaatc caggacctat     5520

ggctgattct aatggaacta taacagttga agaattgaaa aaactattag aacaatggaa     5580

tttggtaata ggatttttgt ttttaacatg gatttgttta ttacaatttg catatgctaa     5640

tagaaataga tttttgtata tcataaaact aatatttttg tggttattat ggccagttac     5700

tttagcatgt tttgttttag cagctgtata tagaattaat tggattacag gaggaattgc     5760

aatagctatg gcatgtctag taggattaat gtggctatct tactttatag catcttttag     5820

actatttgct agaactagat ctatgtggtc ttttaatcct gaaacaaata tattgttaaa     5880

tgtaccatta catggaacta tattgacaag acctctacta gaatctgaat tagttattgg     5940

agcagtaata ttaagaggac atttgagaat tgctggacat catttgggaa gatgtgatat     6000

caaagatttg cctaaagaaa ttactgttgc tacatctaga actttatctt attataaact     6060

aggagcatct caaagagtag ctggagattc tggatttgca gcttattcta gatatagaat     6120

tggaaattat aaattgaata ctgatcattc ttcttcttct gataatattg cattattagt     6180

acaaggatct ggagctacaa atttttcttt gttaaaacag gcaggagatg ttgaagaaaa     6240

tccaggacca atgtattctt ttgtatctga agaaactgga acattaattg ttaattctgt     6300

attattgttt ttagcttttg tagtattttt gctagttaca ttagcaatat tgactgcttt     6360

aagattatgt gcatattgtt gtaatattgt taatgtatct ttagtaaaac catcttttta     6420

tgtatattca agagttaaaa atctaaattc atcaagagtt cctgatctat tggtataata     6480

atttttatgg atcctctaga gtcgacctgc agtcaaactc taatgaccac atcttttttt     6540

agagatgaaa aattttccac atctcctttt gtagacacga ctaaacattt tgcagaaaaa     6600

agtttattag tgtttagata atcgtatact tcatcagtgt agatagtaaa tgtgaacaga     6660

taaaaggtat tcttgctcaa tagattggta aattccatag aatatattaa tcctttcttc     6720

ttgagatccc acatcatttc aaccagagac gttttatcca atgatttacc tcgtactata     6780

ccacatacaa aactagattt tgcagtgacg tcgtatctgg tattcctacc aaacaaaatt     6840

ttacttttag ttcttttaga aaattctaag gtagaatctc tatttgccaa tatgtcatct     6900

atggaattac cactagcaaa aaatgataga aatatatatt gatacatcgc agctggtttt     6960

gatctactat actttaaaaa cgaatcagat tccataattg cctgtatatc atcagctgaa     7020

aaactatgtt ttacacgtat tccttcggca tttcttttta atgatatatc ttgtttagac     7080

aatgataaag ttatcatgtc catgagagac gcgtctccgt atcgtataaa tatttcatta     7140

gatgttagac gcttcattag gggtatactt ctataaggtt tcttaatcag tccatcattg     7200

gttgcgtcaa gaacaagctt gtctccctat agtgagtcgt attagagctt ggcgtaatca     7260

tggtcatagc tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga     7320

gccggaagca taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt     7380

gcgttgcgct cactgcccgc tttcgagtcg ggaaacctgt cgtgccagct gcattaatga     7440

atcggccaac gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc     7500

actgactcgc tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg     7560

gtaatacggt tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc     7620

cagcaaaagg ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcga taggctccgc     7680

ccccctgacg agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga     7740

ctataaagat accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc     7800

ctgccgctta ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcat     7860

agctcacgct gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg     7920

cacgaacccc ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc     7980

aacccggtaa gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga     8040

gcgaggtatg taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact     8100

agaaggacag tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt     8160

ggtagctctt gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag     8220

cagcagatta cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg     8280

tctgacgctc agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa     8340

aggatcttca cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata     8400

tatgagtaaa cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg     8460

atctgtctat ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata     8520

cgggagggct taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg     8580

gctccagatt tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct     8640

gcaactttat ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt     8700

tcgccagtta atagtttgcg caacgttgtt ggcattgcta caggcatcgt ggtgtcacgc     8760

tcgtcgtttg gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga     8820

tcccccatgt tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt     8880

aagttggccg cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc     8940

atgccatccg taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa     9000

tagtgtatgc ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca     9060

catagcagaa ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca     9120

aggatcttac cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct     9180

tcagcatctt ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc     9240

gcaaaaaagg gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa     9300

tattattgaa gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt     9360

tagaaaaata aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc     9420

taagaaacca ttattatcat gacattaacc tataaaaata ggcgtatcac gaggcccttt     9480

cgtctcgcgc gtttcggtga tgacggtgaa aacctctgac acatgcagct cccggagacg     9540

gtcacagctt gtctgtaagc ggatgccggg agcagacaag cccgtcaggg cgcgtcagcg     9600

ggtgttggcg ggtgtcgggg ctggcttaac tatgcggcat cagagcagat tgtactgaga     9660

gtgcaccata tgcggtgtga aataccgcac agatgcgtaa ggagaaaata ccgcatcagg     9720

cgccattcgc cattcaggct gcgcaactgt tgggaagggc gatcggtgcg ggcctcttcg     9780

ctattacgcc agctggcgaa agggggatgt gctgcaaggc gattaagttg ggtaacgcca     9840

gggttttccc agtcacgacg ttgtaaaacg acggccagtg aattggattt aggtgacact     9900

ata                                                                   9903


<210>  6
<211>  4848
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  6
atgtttgttt ttctagtttt gctaccgttg gtttcaagtc aatgtgtaaa tctaactaca       60

agaactcaat taccgcctgc ctatactaat tcttttacaa gaggagtata ttatcctgat      120

aaagttttta gatcttctgt attacattct acacaagatt tgtttttacc atttttctct      180

aatgttactt ggtttcatgc aatacatgta tctggaacta atggaacaaa aagatttgat      240

aatccagtat taccttttaa tgatggagtt tattttgctt ctactgaaaa atctaatata      300

attagaggat ggatatttgg aactacatta gattctaaaa cacaatctct actaattgtt      360

aataatgcaa ctaatgtagt tataaaagta tgtgaatttc aattttgtaa tgatccattt      420

ttgggagttt attatcataa aaataataag tcttggatgg aatctgaatt cagagtatat      480

tcttctgcta ataattgtac atttgaatat gtatctcaac catttttgat ggatttggaa      540

ggaaaacaag gaaactttaa aaatttgaga gaatttgttt ttaaaaatat tgatggatac      600

tttaaaatct attctaaaca tactccaatt aatctagtaa gagatttgcc tcaaggattt      660

tctgctttag aaccactagt agatttgcct ataggaatta atattactag atttcaaaca      720

ttattagctt tacatagatc ttatttgaca cctggagatt cttcttctgg atggactgca      780

ggagctgcag cttattatgt tggatatttg caaccaagaa catttttgtt aaaatataat      840

gaaaatggaa ctataacaga tgcagttgat tgtgctttag atcctctatc tgaaactaaa      900

tgtactttaa aatcttttac tgtagaaaaa ggaatctatc aaacatctaa ctttagagta      960

caaccaactg aatctattgt tagatttcca aatataacaa atctatgtcc ttttggagaa     1020

gtttttaatg caactagatt tgcttctgta tatgcatgga atagaaaaag aatatctaat     1080

tgcgtagctg attattctgt attatataat tctgcatctt tttctacttt taaatgttat     1140

ggagtatctc caacaaaatt gaatgatcta tgttttacta atgtttatgc agattctttt     1200

gtaataagag gagatgaagt tagacaaata gctcctggac aaacaggaaa aatagcagat     1260

tataattata aattaccaga tgatttcact ggatgcgtaa ttgcttggaa ttctaataat     1320

ttggattcta aagtaggagg aaattataat tatttgtata gattgtttag aaaatctaat     1380

ttgaaacctt ttgaaagaga tatttctaca gaaatctatc aagcaggatc tactccatgt     1440

aatggagttg aaggttttaa ttgttatttt ccactacaat cttatggatt tcaacctaca     1500

aatggagtag gatatcaacc atatagagta gttgtattat cttttgaatt attacatgca     1560

ccagctacag tatgtggacc taaaaaatct actaatttgg ttaaaaataa gtgcgtaaac     1620

tttaacttta atggattaac tggaacagga gttttaactg aatctaataa gaaatttttg     1680

ccttttcaac aatttggaag agatattgct gatactacag atgcagtaag agatcctcaa     1740

actttagaaa tattggatat tacaccatgt tcttttggag gagtttctgt aataacacca     1800

ggaactaata catctaatca agttgctgta ttatatcaag atgttaattg tactgaagtt     1860

cctgtagcaa ttcatgctga tcaattaact ccaacatgga gagtatattc tactggatct     1920

aatgtttttc aaacaagagc tggatgtcta attggagcag aacatgtaaa taattcttat     1980

gaatgtgata ttcctatagg agctggaata tgtgcatctt atcaaactca aacaaattct     2040

ccaagaagag ctagatctgt tgcatctcaa tctataattg cttatacaat gtctttagga     2100

gctgaaaatt ctgtagcata ttctaataat tctattgcaa ttcctactaa ctttactatt     2160

tctgtaacta cagaaatatt gccagtttct atgactaaaa catctgtaga ttgtacaatg     2220

tatatatgtg gagattctac tgaatgttct aatttgctac tacaatatgg atctttttgt     2280

actcaattga atagagcttt aacaggaata gcagtagaac aagataaaaa tacacaagaa     2340

gtttttgctc aagtaaaaca aatctataaa actccaccta taaaagattt tggaggtttt     2400

aatttttctc aaatattgcc agatccttct aaaccttcta aaagatcttt tattgaagat     2460

ttgttgttta ataaggttac attagcagat gctggtttta taaaacaata tggagattgt     2520

ttaggagata ttgcagctag agatttgatt tgtgctcaaa agtttaatgg attaactgta     2580

ttaccacctc tactaacaga tgaaatgata gcacaatata catctgcatt attagctgga     2640

actattacat ctggatggac ttttggagct ggagcagctt tacaaatacc atttgctatg     2700

caaatggcat atagattcaa tggaattgga gttactcaaa atgtattata tgaaaatcaa     2760

aaactaattg ctaatcaatt caattctgca attggaaaaa ttcaagattc tctatcttct     2820

acagcatctg ctttaggaaa actacaagat gttgtaaatc aaaatgcaca agctttaaat     2880

actctagtta aacaactatc ttctaatttt ggagctattt cttctgtttt aaatgatata     2940

ttgtctagac tagatccacc tgaagcagaa gtacaaattg atagactaat tacaggaaga     3000

ttacaatctc tacaaactta tgtaacacaa caactaatta gagcagctga aataagagca     3060

tctgctaatt tggcagctac taaaatgtct gaatgcgtat taggacaatc taaaagagta     3120

gatttttgtg gaaaaggata tcatttgatg tcttttccac aatctgctcc tcatggagta     3180

gtatttttgc atgttacata tgtacctgca caagaaaaga actttactac agcaccagct     3240

atatgtcatg atggaaaagc tcattttcct agagaaggag tttttgtatc taatggaact     3300

cattggtttg ttacacaaag aaacttttat gaaccacaaa ttataactac agataataca     3360

tttgtatctg gaaattgtga tgttgtaatt ggaattgtta ataatactgt atatgatcca     3420

ctacaacctg aactagattc ttttaaagaa gaactagata aatactttaa aaatcatact     3480

tctcctgatg ttgatttggg agatatatct ggaattaatg cttctgttgt aaatattcaa     3540

aaagaaatag atagattgaa tgaagtagca aaaaatttga atgaatctct aattgatttg     3600

caagaattag gaaaatatga acaatatatc aaatggccat ggtatatttg gctaggtttt     3660

atagctggat taatagcaat tgttatggta actattatgt tatgttgtat gacatcttgt     3720

tgttcttgtc taaaaggatg ttgttcttgt ggatcttgtt gtaaatttga tgaagatgat     3780

tctgaacctg ttttgaaagg tgttaaacta cattatactg gatctggagc aactaatttt     3840

tctttgttaa aacaagctgg agatgtagaa gaaaatccag gacctatggc tgattctaat     3900

ggaactataa cagttgaaga attgaaaaaa ctattagaac aatggaattt ggtaatagga     3960

tttttgtttt taacatggat ttgtttatta caatttgcat atgctaatag aaatagattt     4020

ttgtatatca taaaactaat atttttgtgg ttattatggc cagttacttt agcatgtttt     4080

gttttagcag ctgtatatag aattaattgg attacaggag gaattgcaat agctatggca     4140

tgtctagtag gattaatgtg gctatcttac tttatagcat cttttagact atttgctaga     4200

actagatcta tgtggtcttt taatcctgaa acaaatatat tgttaaatgt accattacat     4260

ggaactatat tgacaagacc tctactagaa tctgaattag ttattggagc agtaatatta     4320

agaggacatt tgagaattgc tggacatcat ttgggaagat gtgatatcaa agatttgcct     4380

aaagaaatta ctgttgctac atctagaact ttatcttatt ataaactagg agcatctcaa     4440

agagtagctg gagattctgg atttgcagct tattctagat atagaattgg aaattataaa     4500

ttgaatactg atcattcttc ttcttctgat aatattgcat tattagtaca aggatctgga     4560

gctacaaatt tttctttgtt aaaacaggca ggagatgttg aagaaaatcc aggaccaatg     4620

tattcttttg tatctgaaga aactggaaca ttaattgtta attctgtatt attgttttta     4680

gcttttgtag tatttttgct agttacatta gcaatattga ctgctttaag attatgtgca     4740

tattgttgta atattgttaa tgtatcttta gtaaaaccat ctttttatgt atattcaaga     4800

gttaaaaatc taaattcatc aagagttcct gatctattgg tataataa                  4848


<210>  7
<211>  8880
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  7
gaattccctg ggacatacgt atatttctat gatctgtctt atatgaagtc tatacagcga       60

atagattcag aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc      120

cccgaagatt tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat      180

atagactcgt tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg      240

aagatgatag agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat      300

aattttgaga ggacgggaga attaactagt attgtacaag aagccatttt atctctaaat      360

ttacgaatta agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt      420

aaaatattat tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta      480

acgggatata tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaggc      540

gcgcctttca ttttgttttt ttctatgcta taaatggtga gcaagggcga ggagctgttc      600

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      660

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc      720

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg      780

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      840

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      900

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      960

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1020

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     1080

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     1140

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     1200

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     1260

atcactctcg gcatgcacga gctgtacaag taagagctcg aggacgggag aattaactag     1320

tattgtacaa gaagccattt tatctctaaa tttacgaatt aagattttaa attttaaaca     1380

taaagatgat gatacgtata tacacttttg taaaatatta ttcggtgtct ataacggaac     1440

aaacgctact atatattatc atagacctct aacgggatat atgaatatga tttcagatac     1500

tatatttgtt cctgtagata ataactaact cgaggccgct ggtacccaac ctaaaaattg     1560

aaaataaata caaaggttct tgagggttgt gttaaattga aagcgagaaa taatcataaa     1620

taagcccggg accatgtttg tttttctagt tttgctaccg ttggtttcaa gtcaatgtgt     1680

aaatctaact acaagaactc aattaccgcc tgcctatact aattctttta caagaggagt     1740

atattatcct gataaagttt ttagatcttc tgtattacat tctacacaag atttgttttt     1800

accatttttc tctaatgtta cttggtttca tgcaatacat gtatctggaa ctaatggaac     1860

aaaaagattt gataatccag tattaccttt taatgatgga gtttattttg cttctactga     1920

aaaatctaat ataattagag gatggatatt tggaactaca ttagattcta aaacacaatc     1980

tctactaatt gttaataatg caactaatgt agttataaaa gtatgtgaat ttcaattttg     2040

taatgatcca tttttgggag tttattatca taaaaataat aagtcttgga tggaatctga     2100

attcagagta tattcttctg ctaataattg tacatttgaa tatgtatctc aaccattttt     2160

gatggatttg gaaggaaaac aaggaaactt taaaaatttg agagaatttg tttttaaaaa     2220

tattgatgga tactttaaaa tctattctaa acatactcca attaatctag taagagattt     2280

gcctcaagga ttttctgctt tagaaccact agtagatttg cctataggaa ttaatattac     2340

tagatttcaa acattattag ctttacatag atcttatttg acacctggag attcttcttc     2400

tggatggact gcaggagctg cagcttatta tgttggatat ttgcaaccaa gaacattttt     2460

gttaaaatat aatgaaaatg gaactataac agatgcagtt gattgtgctt tagatcctct     2520

atctgaaact aaatgtactt taaaatcttt tactgtagaa aaaggaatct atcaaacatc     2580

taactttaga gtacaaccaa ctgaatctat tgttagattt ccaaatataa caaatctatg     2640

tccttttgga gaagttttta atgcaactag atttgcttct gtatatgcat ggaatagaaa     2700

aagaatatct aattgcgtag ctgattattc tgtattatat aattctgcat ctttttctac     2760

ttttaaatgt tatggagtat ctccaacaaa attgaatgat ctatgtttta ctaatgttta     2820

tgcagattct tttgtaataa gaggagatga agttagacaa atagctcctg gacaaacagg     2880

aaaaatagca gattataatt ataaattacc agatgatttc actggatgcg taattgcttg     2940

gaattctaat aatttggatt ctaaagtagg aggaaattat aattatttgt atagattgtt     3000

tagaaaatct aatttgaaac cttttgaaag agatatttct acagaaatct atcaagcagg     3060

atctactcca tgtaatggag ttgaaggttt taattgttat tttccactac aatcttatgg     3120

atttcaacct acaaatggag taggatatca accatataga gtagttgtat tatcttttga     3180

attattacat gcaccagcta cagtatgtgg acctaaaaaa tctactaatt tggttaaaaa     3240

taagtgcgta aactttaact ttaatggatt aactggaaca ggagttttaa ctgaatctaa     3300

taagaaattt ttgccttttc aacaatttgg aagagatatt gctgatacta cagatgcagt     3360

aagagatcct caaactttag aaatattgga tattacacca tgttcttttg gaggagtttc     3420

tgtaataaca ccaggaacta atacatctaa tcaagttgct gtattatatc aagatgttaa     3480

ttgtactgaa gttcctgtag caattcatgc tgatcaatta actccaacat ggagagtata     3540

ttctactgga tctaatgttt ttcaaacaag agctggatgt ctaattggag cagaacatgt     3600

aaataattct tatgaatgtg atattcctat aggagctgga atatgtgcat cttatcaaac     3660

tcaaacaaat tctccaagaa gagctagatc tgttgcatct caatctataa ttgcttatac     3720

aatgtcttta ggagctgaaa attctgtagc atattctaat aattctattg caattcctac     3780

taactttact atttctgtaa ctacagaaat attgccagtt tctatgacta aaacatctgt     3840

agattgtaca atgtatatat gtggagattc tactgaatgt tctaatttgc tactacaata     3900

tggatctttt tgtactcaat tgaatagagc tttaacagga atagcagtag aacaagataa     3960

aaatacacaa gaagtttttg ctcaagtaaa acaaatctat aaaactccac ctataaaaga     4020

ttttggaggt tttaattttt ctcaaatatt gccagatcct tctaaacctt ctaaaagatc     4080

ttttattgaa gatttgttgt ttaataaggt tacattagca gatgctggtt ttataaaaca     4140

atatggagat tgtttaggag atattgcagc tagagatttg atttgtgctc aaaagtttaa     4200

tggattaact gtattaccac ctctactaac agatgaaatg atagcacaat atacatctgc     4260

attattagct ggaactatta catctggatg gacttttgga gctggagcag ctttacaaat     4320

accatttgct atgcaaatgg catatagatt caatggaatt ggagttactc aaaatgtatt     4380

atatgaaaat caaaaactaa ttgctaatca attcaattct gcaattggaa aaattcaaga     4440

ttctctatct tctacagcat ctgctttagg aaaactacaa gatgttgtaa atcaaaatgc     4500

acaagcttta aatactctag ttaaacaact atcttctaat tttggagcta tttcttctgt     4560

tttaaatgat atattgtcta gactagatcc acctgaagca gaagtacaaa ttgatagact     4620

aattacagga agattacaat ctctacaaac ttatgtaaca caacaactaa ttagagcagc     4680

tgaaataaga gcatctgcta atttggcagc tactaaaatg tctgaatgcg tattaggaca     4740

atctaaaaga gtagattttt gtggaaaagg atatcatttg atgtcttttc cacaatctgc     4800

tcctcatgga gtagtatttt tgcatgttac atatgtacct gcacaagaaa agaactttac     4860

tacagcacca gctatatgtc atgatggaaa agctcatttt cctagagaag gagtttttgt     4920

atctaatgga actcattggt ttgttacaca aagaaacttt tatgaaccac aaattataac     4980

tacagataat acatttgtat ctggaaattg tgatgttgta attggaattg ttaataatac     5040

tgtatatgat ccactacaac ctgaactaga ttcttttaaa gaagaactag ataaatactt     5100

taaaaatcat acttctcctg atgttgattt gggagatata tctggaatta atgcttctgt     5160

tgtaaatatt caaaaagaaa tagatagatt gaatgaagta gcaaaaaatt tgaatgaatc     5220

tctaattgat ttgcaagaat taggaaaata tgaacaatat atcaaatggc catggtatat     5280

ttggctaggt tttatagctg gattaatagc aattgttatg gtaactatta tgttatgttg     5340

tatgacatct tgttgttctt gtctaaaagg atgttgttct tgtggatctt gttgtaaatt     5400

tgatgaagat gattctgaac ctgttttgaa aggtgttaaa ctacattata cttaataatt     5460

tttatggatc ctctagagtc gacctgcagt caaactctaa tgaccacatc tttttttaga     5520

gatgaaaaat tttccacatc tccttttgta gacacgacta aacattttgc agaaaaaagt     5580

ttattagtgt ttagataatc gtatacttca tcagtgtaga tagtaaatgt gaacagataa     5640

aaggtattct tgctcaatag attggtaaat tccatagaat atattaatcc tttcttcttg     5700

agatcccaca tcatttcaac cagagacgtt ttatccaatg atttacctcg tactatacca     5760

catacaaaac tagattttgc agtgacgtcg tatctggtat tcctaccaaa caaaatttta     5820

cttttagttc ttttagaaaa ttctaaggta gaatctctat ttgccaatat gtcatctatg     5880

gaattaccac tagcaaaaaa tgatagaaat atatattgat acatcgcagc tggttttgat     5940

ctactatact ttaaaaacga atcagattcc ataattgcct gtatatcatc agctgaaaaa     6000

ctatgtttta cacgtattcc ttcggcattt ctttttaatg atatatcttg tttagacaat     6060

gataaagtta tcatgtccat gagagacgcg tctccgtatc gtataaatat ttcattagat     6120

gttagacgct tcattagggg tatacttcta taaggtttct taatcagtcc atcattggtt     6180

gcgtcaagaa caagcttgtc tccctatagt gagtcgtatt agagcttggc gtaatcatgg     6240

tcatagctgt ttcctgtgtg aaattgttat ccgctcacaa ttccacacaa catacgagcc     6300

ggaagcataa agtgtaaagc ctggggtgcc taatgagtga gctaactcac attaattgcg     6360

ttgcgctcac tgcccgcttt cgagtcggga aacctgtcgt gccagctgca ttaatgaatc     6420

ggccaacgcg cggggagagg cggtttgcgt attgggcgct cttccgcttc ctcgctcact     6480

gactcgctgc gctcggtcgt tcggctgcgg cgagcggtat cagctcactc aaaggcggta     6540

atacggttat ccacagaatc aggggataac gcaggaaaga acatgtgagc aaaaggccag     6600

caaaaggcca ggaaccgtaa aaaggccgcg ttgctggcgt ttttcgatag gctccgcccc     6660

cctgacgagc atcacaaaaa tcgacgctca agtcagaggt ggcgaaaccc gacaggacta     6720

taaagatacc aggcgtttcc ccctggaagc tccctcgtgc gctctcctgt tccgaccctg     6780

ccgcttaccg gatacctgtc cgcctttctc ccttcgggaa gcgtggcgct ttctcatagc     6840

tcacgctgta ggtatctcag ttcggtgtag gtcgttcgct ccaagctggg ctgtgtgcac     6900

gaaccccccg ttcagcccga ccgctgcgcc ttatccggta actatcgtct tgagtccaac     6960

ccggtaagac acgacttatc gccactggca gcagccactg gtaacaggat tagcagagcg     7020

aggtatgtag gcggtgctac agagttcttg aagtggtggc ctaactacgg ctacactaga     7080

aggacagtat ttggtatctg cgctctgctg aagccagtta ccttcggaaa aagagttggt     7140

agctcttgat ccggcaaaca aaccaccgct ggtagcggtg gtttttttgt ttgcaagcag     7200

cagattacgc gcagaaaaaa aggatctcaa gaagatcctt tgatcttttc tacggggtct     7260

gacgctcagt ggaacgaaaa ctcacgttaa gggattttgg tcatgagatt atcaaaaagg     7320

atcttcacct agatcctttt aaattaaaaa tgaagtttta aatcaatcta aagtatatat     7380

gagtaaactt ggtctgacag ttaccaatgc ttaatcagtg aggcacctat ctcagcgatc     7440

tgtctatttc gttcatccat agttgcctga ctccccgtcg tgtagataac tacgatacgg     7500

gagggcttac catctggccc cagtgctgca atgataccgc gagacccacg ctcaccggct     7560

ccagatttat cagcaataaa ccagccagcc ggaagggccg agcgcagaag tggtcctgca     7620

actttatccg cctccatcca gtctattaat tgttgccggg aagctagagt aagtagttcg     7680

ccagttaata gtttgcgcaa cgttgttggc attgctacag gcatcgtggt gtcacgctcg     7740

tcgtttggta tggcttcatt cagctccggt tcccaacgat caaggcgagt tacatgatcc     7800

cccatgttgt gcaaaaaagc ggttagctcc ttcggtcctc cgatcgttgt cagaagtaag     7860

ttggccgcag tgttatcact catggttatg gcagcactgc ataattctct tactgtcatg     7920

ccatccgtaa gatgcttttc tgtgactggt gagtactcaa ccaagtcatt ctgagaatag     7980

tgtatgcggc gaccgagttg ctcttgcccg gcgtcaatac gggataatac cgcgccacat     8040

agcagaactt taaaagtgct catcattgga aaacgttctt cggggcgaaa actctcaagg     8100

atcttaccgc tgttgagatc cagttcgatg taacccactc gtgcacccaa ctgatcttca     8160

gcatctttta ctttcaccag cgtttctggg tgagcaaaaa caggaaggca aaatgccgca     8220

aaaaagggaa taagggcgac acggaaatgt tgaatactca tactcttcct ttttcaatat     8280

tattgaagca tttatcaggg ttattgtctc atgagcggat acatatttga atgtatttag     8340

aaaaataaac aaataggggt tccgcgcaca tttccccgaa aagtgccacc tgacgtctaa     8400

gaaaccatta ttatcatgac attaacctat aaaaataggc gtatcacgag gccctttcgt     8460

ctcgcgcgtt tcggtgatga cggtgaaaac ctctgacaca tgcagctccc ggagacggtc     8520

acagcttgtc tgtaagcgga tgccgggagc agacaagccc gtcagggcgc gtcagcgggt     8580

gttggcgggt gtcggggctg gcttaactat gcggcatcag agcagattgt actgagagtg     8640

caccatatgc ggtgtgaaat accgcacaga tgcgtaagga gaaaataccg catcaggcgc     8700

cattcgccat tcaggctgcg caactgttgg gaagggcgat cggtgcgggc ctcttcgcta     8760

ttacgccagc tggcgaaagg gggatgtgct gcaaggcgat taagttgggt aacgccaggg     8820

ttttcccagt cacgacgttg taaaacgacg gccagtgaat tggatttagg tgacactata     8880


<210>  8
<211>  3825
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  8
atgtttgttt ttctagtttt gctaccgttg gtttcaagtc aatgtgtaaa tctaactaca       60

agaactcaat taccgcctgc ctatactaat tcttttacaa gaggagtata ttatcctgat      120

aaagttttta gatcttctgt attacattct acacaagatt tgtttttacc atttttctct      180

aatgttactt ggtttcatgc aatacatgta tctggaacta atggaacaaa aagatttgat      240

aatccagtat taccttttaa tgatggagtt tattttgctt ctactgaaaa atctaatata      300

attagaggat ggatatttgg aactacatta gattctaaaa cacaatctct actaattgtt      360

aataatgcaa ctaatgtagt tataaaagta tgtgaatttc aattttgtaa tgatccattt      420

ttgggagttt attatcataa aaataataag tcttggatgg aatctgaatt cagagtatat      480

tcttctgcta ataattgtac atttgaatat gtatctcaac catttttgat ggatttggaa      540

ggaaaacaag gaaactttaa aaatttgaga gaatttgttt ttaaaaatat tgatggatac      600

tttaaaatct attctaaaca tactccaatt aatctagtaa gagatttgcc tcaaggattt      660

tctgctttag aaccactagt agatttgcct ataggaatta atattactag atttcaaaca      720

ttattagctt tacatagatc ttatttgaca cctggagatt cttcttctgg atggactgca      780

ggagctgcag cttattatgt tggatatttg caaccaagaa catttttgtt aaaatataat      840

gaaaatggaa ctataacaga tgcagttgat tgtgctttag atcctctatc tgaaactaaa      900

tgtactttaa aatcttttac tgtagaaaaa ggaatctatc aaacatctaa ctttagagta      960

caaccaactg aatctattgt tagatttcca aatataacaa atctatgtcc ttttggagaa     1020

gtttttaatg caactagatt tgcttctgta tatgcatgga atagaaaaag aatatctaat     1080

tgcgtagctg attattctgt attatataat tctgcatctt tttctacttt taaatgttat     1140

ggagtatctc caacaaaatt gaatgatcta tgttttacta atgtttatgc agattctttt     1200

gtaataagag gagatgaagt tagacaaata gctcctggac aaacaggaaa aatagcagat     1260

tataattata aattaccaga tgatttcact ggatgcgtaa ttgcttggaa ttctaataat     1320

ttggattcta aagtaggagg aaattataat tatttgtata gattgtttag aaaatctaat     1380

ttgaaacctt ttgaaagaga tatttctaca gaaatctatc aagcaggatc tactccatgt     1440

aatggagttg aaggttttaa ttgttatttt ccactacaat cttatggatt tcaacctaca     1500

aatggagtag gatatcaacc atatagagta gttgtattat cttttgaatt attacatgca     1560

ccagctacag tatgtggacc taaaaaatct actaatttgg ttaaaaataa gtgcgtaaac     1620

tttaacttta atggattaac tggaacagga gttttaactg aatctaataa gaaatttttg     1680

ccttttcaac aatttggaag agatattgct gatactacag atgcagtaag agatcctcaa     1740

actttagaaa tattggatat tacaccatgt tcttttggag gagtttctgt aataacacca     1800

ggaactaata catctaatca agttgctgta ttatatcaag atgttaattg tactgaagtt     1860

cctgtagcaa ttcatgctga tcaattaact ccaacatgga gagtatattc tactggatct     1920

aatgtttttc aaacaagagc tggatgtcta attggagcag aacatgtaaa taattcttat     1980

gaatgtgata ttcctatagg agctggaata tgtgcatctt atcaaactca aacaaattct     2040

ccaagaagag ctagatctgt tgcatctcaa tctataattg cttatacaat gtctttagga     2100

gctgaaaatt ctgtagcata ttctaataat tctattgcaa ttcctactaa ctttactatt     2160

tctgtaacta cagaaatatt gccagtttct atgactaaaa catctgtaga ttgtacaatg     2220

tatatatgtg gagattctac tgaatgttct aatttgctac tacaatatgg atctttttgt     2280

actcaattga atagagcttt aacaggaata gcagtagaac aagataaaaa tacacaagaa     2340

gtttttgctc aagtaaaaca aatctataaa actccaccta taaaagattt tggaggtttt     2400

aatttttctc aaatattgcc agatccttct aaaccttcta aaagatcttt tattgaagat     2460

ttgttgttta ataaggttac attagcagat gctggtttta taaaacaata tggagattgt     2520

ttaggagata ttgcagctag agatttgatt tgtgctcaaa agtttaatgg attaactgta     2580

ttaccacctc tactaacaga tgaaatgata gcacaatata catctgcatt attagctgga     2640

actattacat ctggatggac ttttggagct ggagcagctt tacaaatacc atttgctatg     2700

caaatggcat atagattcaa tggaattgga gttactcaaa atgtattata tgaaaatcaa     2760

aaactaattg ctaatcaatt caattctgca attggaaaaa ttcaagattc tctatcttct     2820

acagcatctg ctttaggaaa actacaagat gttgtaaatc aaaatgcaca agctttaaat     2880

actctagtta aacaactatc ttctaatttt ggagctattt cttctgtttt aaatgatata     2940

ttgtctagac tagatccacc tgaagcagaa gtacaaattg atagactaat tacaggaaga     3000

ttacaatctc tacaaactta tgtaacacaa caactaatta gagcagctga aataagagca     3060

tctgctaatt tggcagctac taaaatgtct gaatgcgtat taggacaatc taaaagagta     3120

gatttttgtg gaaaaggata tcatttgatg tcttttccac aatctgctcc tcatggagta     3180

gtatttttgc atgttacata tgtacctgca caagaaaaga actttactac agcaccagct     3240

atatgtcatg atggaaaagc tcattttcct agagaaggag tttttgtatc taatggaact     3300

cattggtttg ttacacaaag aaacttttat gaaccacaaa ttataactac agataataca     3360

tttgtatctg gaaattgtga tgttgtaatt ggaattgtta ataatactgt atatgatcca     3420

ctacaacctg aactagattc ttttaaagaa gaactagata aatactttaa aaatcatact     3480

tctcctgatg ttgatttggg agatatatct ggaattaatg cttctgttgt aaatattcaa     3540

aaagaaatag atagattgaa tgaagtagca aaaaatttga atgaatctct aattgatttg     3600

caagaattag gaaaatatga acaatatatc aaatggccat ggtatatttg gctaggtttt     3660

atagctggat taatagcaat tgttatggta actattatgt tatgttgtat gacatcttgt     3720

tgttcttgtc taaaaggatg ttgttcttgt ggatcttgtt gtaaatttga tgaagatgat     3780

tctgaacctg ttttgaaagg tgttaaacta cattatactt aataa                     3825


<210>  9
<211>  8787
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  9
gaattccctg ggacatacgt atatttctat gatctgtctt atatgaagtc tatacagcga       60

atagattcag aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc      120

cccgaagatt tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat      180

atagactcgt tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg      240

aagatgatag agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat      300

aattttgaga ggacgggaga attaactagt attgtacaag aagccatttt atctctaaat      360

ttacgaatta agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt      420

aaaatattat tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta      480

acgggatata tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaggc      540

gcgcctttca ttttgttttt ttctatgcta taaatggtga gcaagggcga ggagctgttc      600

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      660

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc      720

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg      780

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      840

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      900

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      960

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1020

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     1080

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     1140

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     1200

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     1260

atcactctcg gcatgcacga gctgtacaag taagagctcg aggacgggag aattaactag     1320

tattgtacaa gaagccattt tatctctaaa tttacgaatt aagattttaa attttaaaca     1380

taaagatgat gatacgtata tacacttttg taaaatatta ttcggtgtct ataacggaac     1440

aaacgctact atatattatc atagacctct aacgggatat atgaatatga tttcagatac     1500

tatatttgtt cctgtagata ataactaact cgaggccgct ggtacccaac ctaaaaattg     1560

aaaataaata caaaggttct tgagggttgt gttaaattga aagcgagaaa taatcataaa     1620

taagcccggg accatgtggt tacaaggact actattacta ggtactgttg cctgttcaat     1680

ttcacaatgt gtaaatctaa ctacaagaac tcaattaccg cctgcctata ctaattcttt     1740

tacaagagga gtatattatc ctgataaagt ttttagatct tctgtattac attctacaca     1800

agatttgttt ttaccatttt tctctaatgt tacttggttt catgcaatac atgtatctgg     1860

aactaatgga acaaaaagat ttgataatcc agtattacct tttaatgatg gagtttattt     1920

tgcttctact gaaaaatcta atataattag aggatggata tttggaacta cattagattc     1980

taaaacacaa tctctactaa ttgttaataa tgcaactaat gtagttataa aagtatgtga     2040

atttcaattt tgtaatgatc catttttggg agtttattat cataaaaata ataagtcttg     2100

gatggaatct gaattcagag tatattcttc tgctaataat tgtacatttg aatatgtatc     2160

tcaaccattt ttgatggatt tggaaggaaa acaaggaaac tttaaaaatt tgagagaatt     2220

tgtttttaaa aatattgatg gatactttaa aatctattct aaacatactc caattaatct     2280

agtaagagat ttgcctcaag gattttctgc tttagaacca ctagtagatt tgcctatagg     2340

aattaatatt actagatttc aaacattatt agctttacat agatcttatt tgacacctgg     2400

agattcttct tctggatgga ctgcaggagc tgcagcttat tatgttggat atttgcaacc     2460

aagaacattt ttgttaaaat ataatgaaaa tggaactata acagatgcag ttgattgtgc     2520

tttagatcct ctatctgaaa ctaaatgtac tttaaaatct tttactgtag aaaaaggaat     2580

ctatcaaaca tctaacttta gagtacaacc aactgaatct attgttagat ttccaaatat     2640

aacaaatcta tgtccttttg gagaagtttt taatgcaact agatttgctt ctgtatatgc     2700

atggaataga aaaagaatat ctaattgcgt agctgattat tctgtattat ataattctgc     2760

atctttttct acttttaaat gttatggagt atctccaaca aaattgaatg atctatgttt     2820

tactaatgtt tatgcagatt cttttgtaat aagaggagat gaagttagac aaatagctcc     2880

tggacaaaca ggaaaaatag cagattataa ttataaatta ccagatgatt tcactggatg     2940

cgtaattgct tggaattcta ataatttgga ttctaaagta ggaggaaatt ataattattt     3000

gtatagattg tttagaaaat ctaatttgaa accttttgaa agagatattt ctacagaaat     3060

ctatcaagca ggatctactc catgtaatgg agttgaaggt tttaattgtt attttccact     3120

acaatcttat ggatttcaac ctacaaatgg agtaggatat caaccatata gagtagttgt     3180

attatctttt gaattattac atgcaccagc tacagtatgt ggacctaaaa aatctactaa     3240

tttggttaaa aataagtgcg taaactttaa ctttaatgga ttaactggaa caggagtttt     3300

aactgaatct aataagaaat ttttgccttt tcaacaattt ggaagagata ttgctgatac     3360

tacagatgca gtaagagatc ctcaaacttt agaaatattg gatattacac catgttcttt     3420

tggaggagtt tctgtaataa caccaggaac taatacatct aatcaagttg ctgtattata     3480

tcaagatgtt aattgtactg aagttcctgt agcaattcat gctgatcaat taactccaac     3540

atggagagta tattctactg gatctaatgt ttttcaaaca agagctggat gtctaattgg     3600

agcagaacat gtaaataatt cttatgaatg tgatattcct ataggagctg gaatatgtgc     3660

atcttatcaa actcaaacaa attctccaag aagagctaga tctgttgcat ctcaatctat     3720

aattgcttat acaatgtctt taggagctga aaattctgta gcatattcta ataattctat     3780

tgcaattcct actaacttta ctatttctgt aactacagaa atattgccag tttctatgac     3840

taaaacatct gtagattgta caatgtatat atgtggagat tctactgaat gttctaattt     3900

gctactacaa tatggatctt tttgtactca attgaataga gctttaacag gaatagcagt     3960

agaacaagat aaaaatacac aagaagtttt tgctcaagta aaacaaatct ataaaactcc     4020

acctataaaa gattttggag gttttaattt ttctcaaata ttgccagatc cttctaaacc     4080

ttctaaaaga tcttttattg aagatttgtt gtttaataag gttacattag cagatgctgg     4140

ttttataaaa caatatggag attgtttagg agatattgca gctagagatt tgatttgtgc     4200

tcaaaagttt aatggattaa ctgtattacc acctctacta acagatgaaa tgatagcaca     4260

atatacatct gcattattag ctggaactat tacatctgga tggacttttg gagctggagc     4320

agctttacaa ataccatttg ctatgcaaat ggcatataga ttcaatggaa ttggagttac     4380

tcaaaatgta ttatatgaaa atcaaaaact aattgctaat caattcaatt ctgcaattgg     4440

aaaaattcaa gattctctat cttctacagc atctgcttta ggaaaactac aagatgttgt     4500

aaatcaaaat gcacaagctt taaatactct agttaaacaa ctatcttcta attttggagc     4560

tatttcttct gttttaaatg atatattgtc tagactagat ccacctgaag cagaagtaca     4620

aattgataga ctaattacag gaagattaca atctctacaa acttatgtaa cacaacaact     4680

aattagagca gctgaaataa gagcatctgc taatttggca gctactaaaa tgtctgaatg     4740

cgtattagga caatctaaaa gagtagattt ttgtggaaaa ggatatcatt tgatgtcttt     4800

tccacaatct gctcctcatg gagtagtatt tttgcatgtt acatatgtac ctgcacaaga     4860

aaagaacttt actacagcac cagctatatg tcatgatgga aaagctcatt ttcctagaga     4920

aggagttttt gtatctaatg gaactcattg gtttgttaca caaagaaact tttatgaacc     4980

acaaattata actacagata atacatttgt atctggaaat tgtgatgttg taattggaat     5040

tgttaataat actgtatatg atccactaca acctgaacta gattctttta aagaagaact     5100

agataaatac tttaaaaatc atacttctcc tgatgttgat ttgggagata tatctggaat     5160

taatgcttct gttgtaaata ttcaaaaaga aatagataga ttgaatgaag tagcaaaaaa     5220

tttgaatgaa tctctaattg atttgcaaga attaggaaaa tatgaacaag gatctgctgg     5280

atatattcca gaagcaccta gagatggaca agcgtatgtt agaaaagatg gtgaatgggt     5340

attattgagt acatttttgt aataattttt atggatcctc tagagtcgac ctgcagtcaa     5400

actctaatga ccacatcttt ttttagagat gaaaaatttt ccacatctcc ttttgtagac     5460

acgactaaac attttgcaga aaaaagttta ttagtgttta gataatcgta tacttcatca     5520

gtgtagatag taaatgtgaa cagataaaag gtattcttgc tcaatagatt ggtaaattcc     5580

atagaatata ttaatccttt cttcttgaga tcccacatca tttcaaccag agacgtttta     5640

tccaatgatt tacctcgtac tataccacat acaaaactag attttgcagt gacgtcgtat     5700

ctggtattcc taccaaacaa aattttactt ttagttcttt tagaaaattc taaggtagaa     5760

tctctatttg ccaatatgtc atctatggaa ttaccactag caaaaaatga tagaaatata     5820

tattgataca tcgcagctgg ttttgatcta ctatacttta aaaacgaatc agattccata     5880

attgcctgta tatcatcagc tgaaaaacta tgttttacac gtattccttc ggcatttctt     5940

tttaatgata tatcttgttt agacaatgat aaagttatca tgtccatgag agacgcgtct     6000

ccgtatcgta taaatatttc attagatgtt agacgcttca ttaggggtat acttctataa     6060

ggtttcttaa tcagtccatc attggttgcg tcaagaacaa gcttgtctcc ctatagtgag     6120

tcgtattaga gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa ttgttatccg     6180

ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg gggtgcctaa     6240

tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcga gtcgggaaac     6300

ctgtcgtgcc agctgcatta atgaatcggc caacgcgcgg ggagaggcgg tttgcgtatt     6360

gggcgctctt ccgcttcctc gctcactgac tcgctgcgct cggtcgttcg gctgcggcga     6420

gcggtatcag ctcactcaaa ggcggtaata cggttatcca cagaatcagg ggataacgca     6480

ggaaagaaca tgtgagcaaa aggccagcaa aaggccagga accgtaaaaa ggccgcgttg     6540

ctggcgtttt tcgataggct ccgcccccct gacgagcatc acaaaaatcg acgctcaagt     6600

cagaggtggc gaaacccgac aggactataa agataccagg cgtttccccc tggaagctcc     6660

ctcgtgcgct ctcctgttcc gaccctgccg cttaccggat acctgtccgc ctttctccct     6720

tcgggaagcg tggcgctttc tcatagctca cgctgtaggt atctcagttc ggtgtaggtc     6780

gttcgctcca agctgggctg tgtgcacgaa ccccccgttc agcccgaccg ctgcgcctta     6840

tccggtaact atcgtcttga gtccaacccg gtaagacacg acttatcgcc actggcagca     6900

gccactggta acaggattag cagagcgagg tatgtaggcg gtgctacaga gttcttgaag     6960

tggtggccta actacggcta cactagaagg acagtatttg gtatctgcgc tctgctgaag     7020

ccagttacct tcggaaaaag agttggtagc tcttgatccg gcaaacaaac caccgctggt     7080

agcggtggtt tttttgtttg caagcagcag attacgcgca gaaaaaaagg atctcaagaa     7140

gatcctttga tcttttctac ggggtctgac gctcagtgga acgaaaactc acgttaaggg     7200

attttggtca tgagattatc aaaaaggatc ttcacctaga tccttttaaa ttaaaaatga     7260

agttttaaat caatctaaag tatatatgag taaacttggt ctgacagtta ccaatgctta     7320

atcagtgagg cacctatctc agcgatctgt ctatttcgtt catccatagt tgcctgactc     7380

cccgtcgtgt agataactac gatacgggag ggcttaccat ctggccccag tgctgcaatg     7440

ataccgcgag acccacgctc accggctcca gatttatcag caataaacca gccagccgga     7500

agggccgagc gcagaagtgg tcctgcaact ttatccgcct ccatccagtc tattaattgt     7560

tgccgggaag ctagagtaag tagttcgcca gttaatagtt tgcgcaacgt tgttggcatt     7620

gctacaggca tcgtggtgtc acgctcgtcg tttggtatgg cttcattcag ctccggttcc     7680

caacgatcaa ggcgagttac atgatccccc atgttgtgca aaaaagcggt tagctccttc     7740

ggtcctccga tcgttgtcag aagtaagttg gccgcagtgt tatcactcat ggttatggca     7800

gcactgcata attctcttac tgtcatgcca tccgtaagat gcttttctgt gactggtgag     7860

tactcaacca agtcattctg agaatagtgt atgcggcgac cgagttgctc ttgcccggcg     7920

tcaatacggg ataataccgc gccacatagc agaactttaa aagtgctcat cattggaaaa     7980

cgttcttcgg ggcgaaaact ctcaaggatc ttaccgctgt tgagatccag ttcgatgtaa     8040

cccactcgtg cacccaactg atcttcagca tcttttactt tcaccagcgt ttctgggtga     8100

gcaaaaacag gaaggcaaaa tgccgcaaaa aagggaataa gggcgacacg gaaatgttga     8160

atactcatac tcttcctttt tcaatattat tgaagcattt atcagggtta ttgtctcatg     8220

agcggataca tatttgaatg tatttagaaa aataaacaaa taggggttcc gcgcacattt     8280

ccccgaaaag tgccacctga cgtctaagaa accattatta tcatgacatt aacctataaa     8340

aataggcgta tcacgaggcc ctttcgtctc gcgcgtttcg gtgatgacgg tgaaaacctc     8400

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     8460

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggctggct taactatgcg     8520

gcatcagagc agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc     8580

gtaaggagaa aataccgcat caggcgccat tcgccattca ggctgcgcaa ctgttgggaa     8640

gggcgatcgg tgcgggcctc ttcgctatta cgccagctgg cgaaaggggg atgtgctgca     8700

aggcgattaa gttgggtaac gccagggttt tcccagtcac gacgttgtaa aacgacggcc     8760

agtgaattgg atttaggtga cactata                                         8787


<210>  10
<211>  3732
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  10
atgtggttac aaggactact attactaggt actgttgcct gttcaatttc acaatgtgta       60

aatctaacta caagaactca attaccgcct gcctatacta attcttttac aagaggagta      120

tattatcctg ataaagtttt tagatcttct gtattacatt ctacacaaga tttgttttta      180

ccatttttct ctaatgttac ttggtttcat gcaatacatg tatctggaac taatggaaca      240

aaaagatttg ataatccagt attacctttt aatgatggag tttattttgc ttctactgaa      300

aaatctaata taattagagg atggatattt ggaactacat tagattctaa aacacaatct      360

ctactaattg ttaataatgc aactaatgta gttataaaag tatgtgaatt tcaattttgt      420

aatgatccat ttttgggagt ttattatcat aaaaataata agtcttggat ggaatctgaa      480

ttcagagtat attcttctgc taataattgt acatttgaat atgtatctca accatttttg      540

atggatttgg aaggaaaaca aggaaacttt aaaaatttga gagaatttgt ttttaaaaat      600

attgatggat actttaaaat ctattctaaa catactccaa ttaatctagt aagagatttg      660

cctcaaggat tttctgcttt agaaccacta gtagatttgc ctataggaat taatattact      720

agatttcaaa cattattagc tttacataga tcttatttga cacctggaga ttcttcttct      780

ggatggactg caggagctgc agcttattat gttggatatt tgcaaccaag aacatttttg      840

ttaaaatata atgaaaatgg aactataaca gatgcagttg attgtgcttt agatcctcta      900

tctgaaacta aatgtacttt aaaatctttt actgtagaaa aaggaatcta tcaaacatct      960

aactttagag tacaaccaac tgaatctatt gttagatttc caaatataac aaatctatgt     1020

ccttttggag aagtttttaa tgcaactaga tttgcttctg tatatgcatg gaatagaaaa     1080

agaatatcta attgcgtagc tgattattct gtattatata attctgcatc tttttctact     1140

tttaaatgtt atggagtatc tccaacaaaa ttgaatgatc tatgttttac taatgtttat     1200

gcagattctt ttgtaataag aggagatgaa gttagacaaa tagctcctgg acaaacagga     1260

aaaatagcag attataatta taaattacca gatgatttca ctggatgcgt aattgcttgg     1320

aattctaata atttggattc taaagtagga ggaaattata attatttgta tagattgttt     1380

agaaaatcta atttgaaacc ttttgaaaga gatatttcta cagaaatcta tcaagcagga     1440

tctactccat gtaatggagt tgaaggtttt aattgttatt ttccactaca atcttatgga     1500

tttcaaccta caaatggagt aggatatcaa ccatatagag tagttgtatt atcttttgaa     1560

ttattacatg caccagctac agtatgtgga cctaaaaaat ctactaattt ggttaaaaat     1620

aagtgcgtaa actttaactt taatggatta actggaacag gagttttaac tgaatctaat     1680

aagaaatttt tgccttttca acaatttgga agagatattg ctgatactac agatgcagta     1740

agagatcctc aaactttaga aatattggat attacaccat gttcttttgg aggagtttct     1800

gtaataacac caggaactaa tacatctaat caagttgctg tattatatca agatgttaat     1860

tgtactgaag ttcctgtagc aattcatgct gatcaattaa ctccaacatg gagagtatat     1920

tctactggat ctaatgtttt tcaaacaaga gctggatgtc taattggagc agaacatgta     1980

aataattctt atgaatgtga tattcctata ggagctggaa tatgtgcatc ttatcaaact     2040

caaacaaatt ctccaagaag agctagatct gttgcatctc aatctataat tgcttataca     2100

atgtctttag gagctgaaaa ttctgtagca tattctaata attctattgc aattcctact     2160

aactttacta tttctgtaac tacagaaata ttgccagttt ctatgactaa aacatctgta     2220

gattgtacaa tgtatatatg tggagattct actgaatgtt ctaatttgct actacaatat     2280

ggatcttttt gtactcaatt gaatagagct ttaacaggaa tagcagtaga acaagataaa     2340

aatacacaag aagtttttgc tcaagtaaaa caaatctata aaactccacc tataaaagat     2400

tttggaggtt ttaatttttc tcaaatattg ccagatcctt ctaaaccttc taaaagatct     2460

tttattgaag atttgttgtt taataaggtt acattagcag atgctggttt tataaaacaa     2520

tatggagatt gtttaggaga tattgcagct agagatttga tttgtgctca aaagtttaat     2580

ggattaactg tattaccacc tctactaaca gatgaaatga tagcacaata tacatctgca     2640

ttattagctg gaactattac atctggatgg acttttggag ctggagcagc tttacaaata     2700

ccatttgcta tgcaaatggc atatagattc aatggaattg gagttactca aaatgtatta     2760

tatgaaaatc aaaaactaat tgctaatcaa ttcaattctg caattggaaa aattcaagat     2820

tctctatctt ctacagcatc tgctttagga aaactacaag atgttgtaaa tcaaaatgca     2880

caagctttaa atactctagt taaacaacta tcttctaatt ttggagctat ttcttctgtt     2940

ttaaatgata tattgtctag actagatcca cctgaagcag aagtacaaat tgatagacta     3000

attacaggaa gattacaatc tctacaaact tatgtaacac aacaactaat tagagcagct     3060

gaaataagag catctgctaa tttggcagct actaaaatgt ctgaatgcgt attaggacaa     3120

tctaaaagag tagatttttg tggaaaagga tatcatttga tgtcttttcc acaatctgct     3180

cctcatggag tagtattttt gcatgttaca tatgtacctg cacaagaaaa gaactttact     3240

acagcaccag ctatatgtca tgatggaaaa gctcattttc ctagagaagg agtttttgta     3300

tctaatggaa ctcattggtt tgttacacaa agaaactttt atgaaccaca aattataact     3360

acagataata catttgtatc tggaaattgt gatgttgtaa ttggaattgt taataatact     3420

gtatatgatc cactacaacc tgaactagat tcttttaaag aagaactaga taaatacttt     3480

aaaaatcata cttctcctga tgttgatttg ggagatatat ctggaattaa tgcttctgtt     3540

gtaaatattc aaaaagaaat agatagattg aatgaagtag caaaaaattt gaatgaatct     3600

ctaattgatt tgcaagaatt aggaaaatat gaacaaggat ctgctggata tattccagaa     3660

gcacctagag atggacaagc gtatgttaga aaagatggtg aatgggtatt attgagtaca     3720

tttttgtaat aa                                                         3732


<210>  11
<211>  7413
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  11
gaattccctg ggacatacgt atatttctat gatctgtctt atatgaagtc tatacagcga       60

atagattcag aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc      120

cccgaagatt tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat      180

atagactcgt tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg      240

aagatgatag agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat      300

aattttgaga ggacgggaga attaactagt attgtacaag aagccatttt atctctaaat      360

ttacgaatta agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt      420

aaaatattat tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta      480

acgggatata tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaggc      540

gcgcctttca ttttgttttt ttctatgcta taaatggtga gcaagggcga ggagctgttc      600

accggggtgg tgcccatcct ggtcgagctg gacggcgacg taaacggcca caagttcagc      660

gtgtccggcg agggcgaggg cgatgccacc tacggcaagc tgaccctgaa gttcatctgc      720

accaccggca agctgcccgt gccctggccc accctcgtga ccaccctgac ctacggcgtg      780

cagtgcttca gccgctaccc cgaccacatg aagcagcacg acttcttcaa gtccgccatg      840

cccgaaggct acgtccagga gcgcaccatc ttcttcaagg acgacggcaa ctacaagacc      900

cgcgccgagg tgaagttcga gggcgacacc ctggtgaacc gcatcgagct gaagggcatc      960

gacttcaagg aggacggcaa catcctgggg cacaagctgg agtacaacta caacagccac     1020

aacgtctata tcatggccga caagcagaag aacggcatca aggtgaactt caagatccgc     1080

cacaacatcg aggacggcag cgtgcagctc gccgaccact accagcagaa cacccccatc     1140

ggcgacggcc ccgtgctgct gcccgacaac cactacctga gcacccagtc cgccctgagc     1200

aaagacccca acgagaagcg cgatcacatg gtcctgctgg agttcgtgac cgccgccggg     1260

atcactctcg gcatgcacga gctgtacaag taagagctcg aggacgggag aattaactag     1320

tattgtacaa gaagccattt tatctctaaa tttacgaatt aagattttaa attttaaaca     1380

taaagatgat gatacgtata tacacttttg taaaatatta ttcggtgtct ataacggaac     1440

aaacgctact atatattatc atagacctct aacgggatat atgaatatga tttcagatac     1500

tatatttgtt cctgtagata ataactaact cgaggccgct ggtacccaac ctaaaaattg     1560

aaaataaata caaaggttct tgagggttgt gttaaattga aagcgagaaa taatcataaa     1620

taagcccggg accatgtggt tacaaggact actattacta ggtactgttg cctgttcaat     1680

ttcacaatgt gtaaatctaa ctacaagaac tcaattaccg cctgcctata ctaattcttt     1740

tacaagagga gtatattatc ctgataaagt ttttagatct tctgtattac attctacaca     1800

agatttgttt ttaccatttt tctctaatgt tacttggttt catgcaatac atgtatctgg     1860

aactaatgga acaaaaagat ttgataatcc agtattacct tttaatgatg gagtttattt     1920

tgcttctact gaaaaatcta atataattag aggatggata tttggaacta cattagattc     1980

taaaacacaa tctctactaa ttgttaataa tgcaactaat gtagttataa aagtatgtga     2040

atttcaattt tgtaatgatc catttttggg agtttattat cataaaaata ataagtcttg     2100

gatggaatct gaattcagag tatattcttc tgctaataat tgtacatttg aatatgtatc     2160

tcaaccattt ttgatggatt tggaaggaaa acaaggaaac tttaaaaatt tgagagaatt     2220

tgtttttaaa aatattgatg gatactttaa aatctattct aaacatactc caattaatct     2280

agtaagagat ttgcctcaag gattttctgc tttagaacca ctagtagatt tgcctatagg     2340

aattaatatt actagatttc aaacattatt agctttacat agatcttatt tgacacctgg     2400

agattcttct tctggatgga ctgcaggagc tgcagcttat tatgttggat atttgcaacc     2460

aagaacattt ttgttaaaat ataatgaaaa tggaactata acagatgcag ttgattgtgc     2520

tttagatcct ctatctgaaa ctaaatgtac tttaaaatct tttactgtag aaaaaggaat     2580

ctatcaaaca tctaacttta gagtacaacc aactgaatct attgttagat ttccaaatat     2640

aacaaatcta tgtccttttg gagaagtttt taatgcaact agatttgctt ctgtatatgc     2700

atggaataga aaaagaatat ctaattgcgt agctgattat tctgtattat ataattctgc     2760

atctttttct acttttaaat gttatggagt atctccaaca aaattgaatg atctatgttt     2820

tactaatgtt tatgcagatt cttttgtaat aagaggagat gaagttagac aaatagctcc     2880

tggacaaaca ggaaaaatag cagattataa ttataaatta ccagatgatt tcactggatg     2940

cgtaattgct tggaattcta ataatttgga ttctaaagta ggaggaaatt ataattattt     3000

gtatagattg tttagaaaat ctaatttgaa accttttgaa agagatattt ctacagaaat     3060

ctatcaagca ggatctactc catgtaatgg agttgaaggt tttaattgtt attttccact     3120

acaatcttat ggatttcaac ctacaaatgg agtaggatat caaccatata gagtagttgt     3180

attatctttt gaattattac atgcaccagc tacagtatgt ggacctaaaa aatctactaa     3240

tttggttaaa aataagtgcg taaactttaa ctttaatgga ttaactggaa caggagtttt     3300

aactgaatct aataagaaat ttttgccttt tcaacaattt ggaagagata ttgctgatac     3360

tacagatgca gtaagagatc ctcaaacttt agaaatattg gatattacac catgttcttt     3420

tggaggagtt tctgtaataa caccaggaac taatacatct aatcaagttg ctgtattata     3480

tcaagatgtt aattgtactg aagttcctgt agcaattcat gctgatcaat taactccaac     3540

atggagagta tattctactg gatctaatgt ttttcaaaca agagctggat gtctaattgg     3600

agcagaacat gtaaataatt cttatgaatg tgatattcct ataggagctg gaatatgtgc     3660

atcttatcaa actcaaacaa attctccaag aagagctaga tctgttgcat ctcaatctat     3720

aattgcttat acaatgtctt taggagctga aaattctgta gcatattcta ataattctat     3780

tgcaattcct actaacttta ctatttctgt aactacagaa atattgccag tttctatgac     3840

taaaacatct gtagattgta caatgtatat atgtggagat tctactgaat gttctaattt     3900

gctactacaa tatggatctt tttgtactca attgaataga gctttaacag gaatagcagt     3960

agaacaagat aaaaatacac aagaataata atttttatgg atcctctaga gtcgacctgc     4020

agtcaaactc taatgaccac atcttttttt agagatgaaa aattttccac atctcctttt     4080

gtagacacga ctaaacattt tgcagaaaaa agtttattag tgtttagata atcgtatact     4140

tcatcagtgt agatagtaaa tgtgaacaga taaaaggtat tcttgctcaa tagattggta     4200

aattccatag aatatattaa tcctttcttc ttgagatccc acatcatttc aaccagagac     4260

gttttatcca atgatttacc tcgtactata ccacatacaa aactagattt tgcagtgacg     4320

tcgtatctgg tattcctacc aaacaaaatt ttacttttag ttcttttaga aaattctaag     4380

gtagaatctc tatttgccaa tatgtcatct atggaattac cactagcaaa aaatgataga     4440

aatatatatt gatacatcgc agctggtttt gatctactat actttaaaaa cgaatcagat     4500

tccataattg cctgtatatc atcagctgaa aaactatgtt ttacacgtat tccttcggca     4560

tttcttttta atgatatatc ttgtttagac aatgataaag ttatcatgtc catgagagac     4620

gcgtctccgt atcgtataaa tatttcatta gatgttagac gcttcattag gggtatactt     4680

ctataaggtt tcttaatcag tccatcattg gttgcgtcaa gaacaagctt gtctccctat     4740

agtgagtcgt attagagctt ggcgtaatca tggtcatagc tgtttcctgt gtgaaattgt     4800

tatccgctca caattccaca caacatacga gccggaagca taaagtgtaa agcctggggt     4860

gcctaatgag tgagctaact cacattaatt gcgttgcgct cactgcccgc tttcgagtcg     4920

ggaaacctgt cgtgccagct gcattaatga atcggccaac gcgcggggag aggcggtttg     4980

cgtattgggc gctcttccgc ttcctcgctc actgactcgc tgcgctcggt cgttcggctg     5040

cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt tatccacaga atcaggggat     5100

aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg ccaggaaccg taaaaaggcc     5160

gcgttgctgg cgtttttcga taggctccgc ccccctgacg agcatcacaa aaatcgacgc     5220

tcaagtcaga ggtggcgaaa cccgacagga ctataaagat accaggcgtt tccccctgga     5280

agctccctcg tgcgctctcc tgttccgacc ctgccgctta ccggatacct gtccgccttt     5340

ctcccttcgg gaagcgtggc gctttctcat agctcacgct gtaggtatct cagttcggtg     5400

taggtcgttc gctccaagct gggctgtgtg cacgaacccc ccgttcagcc cgaccgctgc     5460

gccttatccg gtaactatcg tcttgagtcc aacccggtaa gacacgactt atcgccactg     5520

gcagcagcca ctggtaacag gattagcaga gcgaggtatg taggcggtgc tacagagttc     5580

ttgaagtggt ggcctaacta cggctacact agaaggacag tatttggtat ctgcgctctg     5640

ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt gatccggcaa acaaaccacc     5700

gctggtagcg gtggtttttt tgtttgcaag cagcagatta cgcgcagaaa aaaaggatct     5760

caagaagatc ctttgatctt ttctacgggg tctgacgctc agtggaacga aaactcacgt     5820

taagggattt tggtcatgag attatcaaaa aggatcttca cctagatcct tttaaattaa     5880

aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa cttggtctga cagttaccaa     5940

tgcttaatca gtgaggcacc tatctcagcg atctgtctat ttcgttcatc catagttgcc     6000

tgactccccg tcgtgtagat aactacgata cgggagggct taccatctgg ccccagtgct     6060

gcaatgatac cgcgagaccc acgctcaccg gctccagatt tatcagcaat aaaccagcca     6120

gccggaaggg ccgagcgcag aagtggtcct gcaactttat ccgcctccat ccagtctatt     6180

aattgttgcc gggaagctag agtaagtagt tcgccagtta atagtttgcg caacgttgtt     6240

ggcattgcta caggcatcgt ggtgtcacgc tcgtcgtttg gtatggcttc attcagctcc     6300

ggttcccaac gatcaaggcg agttacatga tcccccatgt tgtgcaaaaa agcggttagc     6360

tccttcggtc ctccgatcgt tgtcagaagt aagttggccg cagtgttatc actcatggtt     6420

atggcagcac tgcataattc tcttactgtc atgccatccg taagatgctt ttctgtgact     6480

ggtgagtact caaccaagtc attctgagaa tagtgtatgc ggcgaccgag ttgctcttgc     6540

ccggcgtcaa tacgggataa taccgcgcca catagcagaa ctttaaaagt gctcatcatt     6600

ggaaaacgtt cttcggggcg aaaactctca aggatcttac cgctgttgag atccagttcg     6660

atgtaaccca ctcgtgcacc caactgatct tcagcatctt ttactttcac cagcgtttct     6720

gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg gaataagggc gacacggaaa     6780

tgttgaatac tcatactctt cctttttcaa tattattgaa gcatttatca gggttattgt     6840

ctcatgagcg gatacatatt tgaatgtatt tagaaaaata aacaaatagg ggttccgcgc     6900

acatttcccc gaaaagtgcc acctgacgtc taagaaacca ttattatcat gacattaacc     6960

tataaaaata ggcgtatcac gaggcccttt cgtctcgcgc gtttcggtga tgacggtgaa     7020

aacctctgac acatgcagct cccggagacg gtcacagctt gtctgtaagc ggatgccggg     7080

agcagacaag cccgtcaggg cgcgtcagcg ggtgttggcg ggtgtcgggg ctggcttaac     7140

tatgcggcat cagagcagat tgtactgaga gtgcaccata tgcggtgtga aataccgcac     7200

agatgcgtaa ggagaaaata ccgcatcagg cgccattcgc cattcaggct gcgcaactgt     7260

tgggaagggc gatcggtgcg ggcctcttcg ctattacgcc agctggcgaa agggggatgt     7320

gctgcaaggc gattaagttg ggtaacgcca gggttttccc agtcacgacg ttgtaaaacg     7380

acggccagtg aattggattt aggtgacact ata                                  7413


<210>  12
<211>  2358
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  12
atgtggttac aaggactact attactaggt actgttgcct gttcaatttc acaatgtgta       60

aatctaacta caagaactca attaccgcct gcctatacta attcttttac aagaggagta      120

tattatcctg ataaagtttt tagatcttct gtattacatt ctacacaaga tttgttttta      180

ccatttttct ctaatgttac ttggtttcat gcaatacatg tatctggaac taatggaaca      240

aaaagatttg ataatccagt attacctttt aatgatggag tttattttgc ttctactgaa      300

aaatctaata taattagagg atggatattt ggaactacat tagattctaa aacacaatct      360

ctactaattg ttaataatgc aactaatgta gttataaaag tatgtgaatt tcaattttgt      420

aatgatccat ttttgggagt ttattatcat aaaaataata agtcttggat ggaatctgaa      480

ttcagagtat attcttctgc taataattgt acatttgaat atgtatctca accatttttg      540

atggatttgg aaggaaaaca aggaaacttt aaaaatttga gagaatttgt ttttaaaaat      600

attgatggat actttaaaat ctattctaaa catactccaa ttaatctagt aagagatttg      660

cctcaaggat tttctgcttt agaaccacta gtagatttgc ctataggaat taatattact      720

agatttcaaa cattattagc tttacataga tcttatttga cacctggaga ttcttcttct      780

ggatggactg caggagctgc agcttattat gttggatatt tgcaaccaag aacatttttg      840

ttaaaatata atgaaaatgg aactataaca gatgcagttg attgtgcttt agatcctcta      900

tctgaaacta aatgtacttt aaaatctttt actgtagaaa aaggaatcta tcaaacatct      960

aactttagag tacaaccaac tgaatctatt gttagatttc caaatataac aaatctatgt     1020

ccttttggag aagtttttaa tgcaactaga tttgcttctg tatatgcatg gaatagaaaa     1080

agaatatcta attgcgtagc tgattattct gtattatata attctgcatc tttttctact     1140

tttaaatgtt atggagtatc tccaacaaaa ttgaatgatc tatgttttac taatgtttat     1200

gcagattctt ttgtaataag aggagatgaa gttagacaaa tagctcctgg acaaacagga     1260

aaaatagcag attataatta taaattacca gatgatttca ctggatgcgt aattgcttgg     1320

aattctaata atttggattc taaagtagga ggaaattata attatttgta tagattgttt     1380

agaaaatcta atttgaaacc ttttgaaaga gatatttcta cagaaatcta tcaagcagga     1440

tctactccat gtaatggagt tgaaggtttt aattgttatt ttccactaca atcttatgga     1500

tttcaaccta caaatggagt aggatatcaa ccatatagag tagttgtatt atcttttgaa     1560

ttattacatg caccagctac agtatgtgga cctaaaaaat ctactaattt ggttaaaaat     1620

aagtgcgtaa actttaactt taatggatta actggaacag gagttttaac tgaatctaat     1680

aagaaatttt tgccttttca acaatttgga agagatattg ctgatactac agatgcagta     1740

agagatcctc aaactttaga aatattggat attacaccat gttcttttgg aggagtttct     1800

gtaataacac caggaactaa tacatctaat caagttgctg tattatatca agatgttaat     1860

tgtactgaag ttcctgtagc aattcatgct gatcaattaa ctccaacatg gagagtatat     1920

tctactggat ctaatgtttt tcaaacaaga gctggatgtc taattggagc agaacatgta     1980

aataattctt atgaatgtga tattcctata ggagctggaa tatgtgcatc ttatcaaact     2040

caaacaaatt ctccaagaag agctagatct gttgcatctc aatctataat tgcttataca     2100

atgtctttag gagctgaaaa ttctgtagca tattctaata attctattgc aattcctact     2160

aactttacta tttctgtaac tacagaaata ttgccagttt ctatgactaa aacatctgta     2220

gattgtacaa tgtatatatg tggagattct actgaatgtt ctaatttgct actacaatat     2280

ggatcttttt gtactcaatt gaatagagct ttaacaggaa tagcagtaga acaagataaa     2340

aatacacaag aataataa                                                   2358


<210>  13
<211>  8670
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  13
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acgggttcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      240

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      300

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtccgccccc      360

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttacg      420

ggactttcct acttggcagt acatctacgg tattagtcat cggctattac catggtgatg      480

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      540

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      600

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      660

gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc      720

tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc      780

attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag actctatagg      840

cacacccctt tggctcttat gcatgctata ctgtttttgg cttggggcct atacaccccc      900

gcttccttat gctataggtg atggtatagc ttagcctata ggtgtgggtt attgaccatt      960

attgaccact cccctattgg tgacgatact ttccattact aatccataac atggctcttt     1020

gccacaacta tctctattgg ctatatgcca atactctgtc cttcagagac tgacacggac     1080

tctgtatttt tacaggatgg ggtcccattt attatttaca aattcacata tacaacaacg     1140

ccgtcccccg tgcccgcagt ttttattaaa catagcgtgg gatctccacg cgaatctcgg     1200

gtaccgtgtt ccggacatgg gytcttctcc ggtagcggcg gagcttccac atccgagccc     1260

tggtcccatg cctccagcgg ctcatggtcg ctcggcagct ccttgctcct aacagtggag     1320

gccagactta ggcacagcac aatgcccacc accaccagtg tgccgcacaa ggccgtggcg     1380

gtagggtatg tgtctgaaaa tgagctcgga gattgggctc gcaccgctga cgcagatgga     1440

agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtatt ctgataagag     1500

tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta     1560

ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt     1620

tccatgggtc ttttctgcag tcaccatcga tatgtttgtc ttcctggtcc tgctgcctct     1680

ggtctcctca cagtgcgtca atctgactac ccgaactcag ctgccccccg cctacaccaa     1740

ctccttcacc cggggcgtgt actatccaga caaggtgttt agaagctccg tgctgcactc     1800

cacccaggat ctgtttctgc ccttcttttc taatgtgaca tggttccacg ccatccacgt     1860

gagcggcacc aacggcacaa agaggttcga caaccctgtg ctgccattca atgatggcgt     1920

gtactttgcc tccaccgaga agtctaacat catccgcggc tggatctttg gcaccacact     1980

ggactccaag acccagtccc tgctgatcgt gaacaatgcc acaaacgtgg tcatcaaggt     2040

gtgcgagttc cagttttgta acgatccttt cctgggcgtg tactatcaca agaacaataa     2100

gtcttggatg gagagcgagt ttagggtgta ttctagcgcc aacaattgca ccttcgagta     2160

cgtgtcccag ccatttctga tggacctgga gggcaagcag ggcaatttca agaacctgcg     2220

ggagttcgtg tttaagaaca tcgacggcta cttcaagatc tactccaagc acacccccat     2280

caacctggtg cgggacctgc cacagggctt ctctgccctg gagcctctgg tggatctgcc     2340

aatcggcatc aacatcacac ggtttcagac cctgctggcc ctgcacagaa gctacctgac     2400

ccctggcgac tcctctagcg gatggacagc aggagcagca gcatactatg tgggctatct     2460

gcagccacgg accttcctgc tgaagtacaa cgagaatggc accatcacag acgccgtgga     2520

ttgcgccctg gatccactgt ctgagacaaa gtgtacactg aagagcttta cagtggagaa     2580

gggcatctat cagaccagca acttcagggt gcagcccaca gagtccatcg tgcgctttcc     2640

aaatatcacc aacctgtgcc ccttcggcga ggtgtttaat gccacaagat tcgccagcgt     2700

gtacgcctgg aacaggaagc gcatctccaa ttgcgtggcc gactattctg tgctgtacaa     2760

ctctgccagc ttctccacct ttaagtgcta tggcgtgagc cccaccaagc tgaacgacct     2820

gtgcttcaca aacgtgtacg ccgattcctt tgtgatcagg ggcgacgagg tgcgccagat     2880

cgcaccagga cagaccggca agatcgcaga ctacaactat aagctgcccg acgatttcac     2940

aggctgcgtg atcgcctgga attccaacaa tctggattct aaagtgggcg gcaactacaa     3000

ttatctgtac aggctgttcc gcaagtctaa cctgaagcct tttgagcggg acatctccac     3060

cgagatctac caggccggct ctacaccatg caacggcgtg gagggcttca attgttattt     3120

tcccctgcag agctacggct tccagcctac caatggcgtg ggctatcagc catacagagt     3180

ggtggtgctg tcttttgagc tgctgcacgc accagcaacc gtgtgcggac ctaagaagag     3240

cacaaatctg gtgaagaaca agtgcgtgaa cttcaacttc aacggcctga ccggaacagg     3300

cgtgctgacc gagtccaaca agaagttcct gccctttcag cagttcggca gggacatcgc     3360

agataccaca gacgccgtgc gcgaccccca gacactggag atcctggata tcaccccttg     3420

cagcttcggc ggcgtgtccg tgatcacccc tggaaccaat acaagcaacc aggtggccgt     3480

gctgtatcag gacgtgaact gtacagaggt gccagtggcc atccacgccg atcagctgac     3540

ccccacatgg cgggtgtact ccacaggctc taacgtgttc cagaccagag caggatgcct     3600

gatcggagca gagcacgtga acaatagcta tgagtgcgac atccccatcg gcgccggcat     3660

ctgtgcctcc taccagaccc agacaaactc ccctcggaga gccaggtctg tggcctctca     3720

gagcatcatc gcctatacca tgagcctggg cgccgagaac tccgtggcct acagcaacaa     3780

ttccatcgcc atccccacca atttcacaat ctccgtgacc acagagatcc tgcccgtgag     3840

catgaccaag acaagcgtgg actgcaccat gtatatctgt ggcgattcca cagagtgctc     3900

taatctgctg ctgcagtacg gctctttttg tacacagctg aaccgcgccc tgaccggaat     3960

cgcagtggag caggacaaga atacccagga ggtgttcgcc caggtgaagc agatctacaa     4020

gacaccccct atcaaggact ttggcggctt caactttagc cagatcctgc ctgatccatc     4080

taagcctagc aagaggtcct tcatcgagga cctgctgttt aataaggtga ccctggccga     4140

tgccggcttc atcaagcagt atggcgattg cctgggcgac atcgcagcac gcgacctgat     4200

ctgtgcccag aagtttaacg gcctgacagt gctgccaccc ctgctgaccg atgagatgat     4260

cgcacagtac acctctgccc tgctggccgg aaccatcaca agcggatgga cattcggcgc     4320

aggagccgcc ctgcagatcc cattcgccat gcagatggcc tatcggttta atggcatcgg     4380

cgtgacccag aacgtgctgt acgagaatca gaagctgatc gccaatcagt ttaactccgc     4440

catcggcaag atccaggact ctctgtcctc taccgccagc gccctgggca agctgcagga     4500

tgtggtgaat cagaacgccc aggccctgaa cacactggtg aagcagctga gctccaattt     4560

cggcgccatc tctagcgtgc tgaacgatat cctgagcagg ctggacaagg tggaggccga     4620

ggtgcagatc gaccggctga tcaccggcag actgcagtcc ctgcagacct acgtgacaca     4680

gcagctgatc agggcagcag agatcagggc ctctgccaac ctggcagcaa caaagatgag     4740

cgagtgcgtg ctgggacagt ccaagagggt ggacttttgt ggcaagggct atcacctgat     4800

gagcttccca cagtccgccc cacacggagt ggtgtttctg cacgtgacct acgtgcctgc     4860

ccaggagaag aatttcacca cagccccagc catctgccac gatggcaagg cacacttccc     4920

aagggagggc gtgtttgtga gcaatggcac acactggttc gtgacccaga gaaactttta     4980

cgagcctcag atcatcacca cagacaacac cttcgtgagc ggcaattgtg acgtggtcat     5040

cggcatcgtg aacaatacag tgtatgatcc cctgcagcct gagctggact ctttcaagga     5100

ggagctggat aagtacttta agaaccacac cagccccgac gtggatctgg gcgacatctc     5160

cggcatcaac gcctctgtgg tgaatatcca gaaggagatc gacagactga atgaggtggc     5220

caagaatctg aacgagagcc tgatcgacct gcaggagctg ggcaagtatg agcagtacat     5280

caagtggcca tggtatatct ggctgggctt catcgccggc ctgatcgcca tcgtgatggt     5340

gacaatcatg ctgtgctgta tgacctcttg ctgtagctgc ctgaagggct gctgttcctg     5400

tggctcttgc tgtaagttcg atgaggacga ttccgagccc gtgctgaagg gcgtgaagct     5460

gcactacaca ggctccggcg ccaccaactt ttctctgctg aagcaggcag gcgacgtgga     5520

ggagaaccca ggacctatgg ccgatagcaa tggcaccatc acagtggagg agctgaagaa     5580

gctgctggag cagtggaacc tggtcatcgg cttcctgttt ctgacctgga tctgcctgct     5640

gcagttcgcc tatgccaatc ggaacagatt tctgtacatc atcaagctga tcttcctgtg     5700

gctgctgtgg ccagtgaccc tggcctgctt cgtgctggcc gccgtgtatc ggatcaactg     5760

gatcacaggc ggcatcgcca tcgccatggc ctgtctggtg ggcctgatgt ggctgagcta     5820

cttcatcgcc tcctttagac tgttcgccag gacccgcagc atgtggtcct ttaatcccga     5880

gacaaacatc ctgctgaatg tgcctctgca cggcaccatc ctgacaaggc cactgctgga     5940

gtccgagctg gtcatcggag ccgtgatcct gaggggacac ctgagaatcg caggacacca     6000

cctgggccgc tgcgatatca aggacctgcc taaggagatc accgtggcca catctaggac     6060

cctgagctac tataagctgg gagccagcca gagggtggca ggcgacagcg gattcgcagc     6120

atattcccgg tacagaatcg gcaactacaa gctgaatacc gatcactcct ctagctccga     6180

caatatcgcc ctgctggtgc agggatctgg agcaacaaac ttcagcctgc tgaagcaggc     6240

cggcgatgtg gaagaaaacc caggacccat gtattctttt gtgagcgagg agacaggcac     6300

actgatcgtg aatagcgtgc tgctgtttct ggccttcgtg gtgtttctgc tggtgacact     6360

ggccatcctg accgccctga gactgtgcgc ctactgctgt aatatcgtga acgtgtctct     6420

ggtgaagccc agcttttacg tgtatagtag ggtgaagaat ctgaactcaa gtagggtgcc     6480

cgatctgctg gtctaagcta gccccgggtg ataaacggac cgcgcaatcc ctaggctgtg     6540

ccttctagtt gccagccatc tgttgtttgc ccctcccccg tgccttcctt gaccctggaa     6600

ggtgccactc ccactgtcct ttcctaataa aatgaggaaa ttgcatcgca ttgtctgagt     6660

aggtgtcatt ctattctggg gggtggggtg gggcaggaca gcaaggggga ggattgggaa     6720

gacaatagca ggcatgctgg ggatgcggtg ggctctatat aaaaaacgcc cggcggcaac     6780

cgagcgttct gaacgctaga gtcgacaaat tcagaagaac tcgtcaagaa ggcgatagaa     6840

ggcgatgcgc tgcgaatcgg gagcggcgat accgtaaagc acgaggaagc ggtcagccca     6900

ttcgccgcca agctcttcag caatatcacg ggtagccaac gctatgtcct gatagcggtc     6960

tgccacaccc agccggccac agtcgatgaa tccagaaaag cggccatttt ccaccatgat     7020

attcggcaag caggcatcgc catgggtcac gacgagatcc tcgccgtcgg gcatgctcgc     7080

cttgagcctg gcgaacagtt cggctggcgc gagcccctga tgctcttcgt ccagatcatc     7140

ctgatcgaca agaccggctt ccatccgagt acgtgctcgc tcgatgcgat gtttcgcttg     7200

gtggtcgaat gggcaggtag ccggatcaag cgtatgcagc cgccgcattg catcagccat     7260

gatggatact ttctcggcag gagcaaggtg agatgacagg agatcctgcc ccggcacttc     7320

gcccaatagc agccagtccc ttcccgcttc agtgacaacg tcgagcacag ctgcgcaagg     7380

aacgcccgtc gtggccagcc acgatagccg cgctgcctcg tcttgcagtt cattcagggc     7440

accggacagg tcggtcttga caaaaagaac cgggcgcccc tgcgctgaca gccggaacac     7500

ggcggcatca gagcagccga ttgtctgttg tgcccagtca tagccgaata gcctctccac     7560

ccaagcggcc ggagaacctg cgtgcaatcc atcttgttca atcatgcgaa acgatcctca     7620

tcctgtctct tgatcagatc ttgatcccct gcgccatcag atccttggcg gcaagaaagc     7680

catccagttt actttgcagg gcttcccaac cttaccagag ggcgccccag ctggcaattc     7740

cggttcgctt gctgtccata aaaccgccca gtctagctat cgccatgtaa gcccactgca     7800

agctacctgc tttctctttg cgcttgcgtt ttcccttgtc cagatagccc agtagctgac     7860

attcatccgg ggtcagcacc gtttctgcgg actggctttc tacgtgaaaa ggatctaggt     7920

gaagatcctt tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg     7980

agcgtcagac cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt     8040

aatctgctgc ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca     8100

agagctacca actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac     8160

tgttcttcta gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac     8220

atacctcgct ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct     8280

taccgggttg gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg     8340

gggttcgtgc acacagccca gcttggagcg aacgacctac acccgaactg agatacctac     8400

agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac aggtatccgg     8460

taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga aacgcctggt     8520

atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt ttgtgatgct     8580

cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccctttta cggttcctgg     8640

ccttttgctg gccttttgct cacatgttgt                                      8670


<210>  14
<211>  4845
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  14
atgtttgtct tcctggtcct gctgcctctg gtctcctcac agtgcgtcaa tctgactacc       60

cgaactcagc tgccccccgc ctacaccaac tccttcaccc ggggcgtgta ctatccagac      120

aaggtgttta gaagctccgt gctgcactcc acccaggatc tgtttctgcc cttcttttct      180

aatgtgacat ggttccacgc catccacgtg agcggcacca acggcacaaa gaggttcgac      240

aaccctgtgc tgccattcaa tgatggcgtg tactttgcct ccaccgagaa gtctaacatc      300

atccgcggct ggatctttgg caccacactg gactccaaga cccagtccct gctgatcgtg      360

aacaatgcca caaacgtggt catcaaggtg tgcgagttcc agttttgtaa cgatcctttc      420

ctgggcgtgt actatcacaa gaacaataag tcttggatgg agagcgagtt tagggtgtat      480

tctagcgcca acaattgcac cttcgagtac gtgtcccagc catttctgat ggacctggag      540

ggcaagcagg gcaatttcaa gaacctgcgg gagttcgtgt ttaagaacat cgacggctac      600

ttcaagatct actccaagca cacccccatc aacctggtgc gggacctgcc acagggcttc      660

tctgccctgg agcctctggt ggatctgcca atcggcatca acatcacacg gtttcagacc      720

ctgctggccc tgcacagaag ctacctgacc cctggcgact cctctagcgg atggacagca      780

ggagcagcag catactatgt gggctatctg cagccacgga ccttcctgct gaagtacaac      840

gagaatggca ccatcacaga cgccgtggat tgcgccctgg atccactgtc tgagacaaag      900

tgtacactga agagctttac agtggagaag ggcatctatc agaccagcaa cttcagggtg      960

cagcccacag agtccatcgt gcgctttcca aatatcacca acctgtgccc cttcggcgag     1020

gtgtttaatg ccacaagatt cgccagcgtg tacgcctgga acaggaagcg catctccaat     1080

tgcgtggccg actattctgt gctgtacaac tctgccagct tctccacctt taagtgctat     1140

ggcgtgagcc ccaccaagct gaacgacctg tgcttcacaa acgtgtacgc cgattccttt     1200

gtgatcaggg gcgacgaggt gcgccagatc gcaccaggac agaccggcaa gatcgcagac     1260

tacaactata agctgcccga cgatttcaca ggctgcgtga tcgcctggaa ttccaacaat     1320

ctggattcta aagtgggcgg caactacaat tatctgtaca ggctgttccg caagtctaac     1380

ctgaagcctt ttgagcggga catctccacc gagatctacc aggccggctc tacaccatgc     1440

aacggcgtgg agggcttcaa ttgttatttt cccctgcaga gctacggctt ccagcctacc     1500

aatggcgtgg gctatcagcc atacagagtg gtggtgctgt cttttgagct gctgcacgca     1560

ccagcaaccg tgtgcggacc taagaagagc acaaatctgg tgaagaacaa gtgcgtgaac     1620

ttcaacttca acggcctgac cggaacaggc gtgctgaccg agtccaacaa gaagttcctg     1680

ccctttcagc agttcggcag ggacatcgca gataccacag acgccgtgcg cgacccccag     1740

acactggaga tcctggatat caccccttgc agcttcggcg gcgtgtccgt gatcacccct     1800

ggaaccaata caagcaacca ggtggccgtg ctgtatcagg acgtgaactg tacagaggtg     1860

ccagtggcca tccacgccga tcagctgacc cccacatggc gggtgtactc cacaggctct     1920

aacgtgttcc agaccagagc aggatgcctg atcggagcag agcacgtgaa caatagctat     1980

gagtgcgaca tccccatcgg cgccggcatc tgtgcctcct accagaccca gacaaactcc     2040

cctcggagag ccaggtctgt ggcctctcag agcatcatcg cctataccat gagcctgggc     2100

gccgagaact ccgtggccta cagcaacaat tccatcgcca tccccaccaa tttcacaatc     2160

tccgtgacca cagagatcct gcccgtgagc atgaccaaga caagcgtgga ctgcaccatg     2220

tatatctgtg gcgattccac agagtgctct aatctgctgc tgcagtacgg ctctttttgt     2280

acacagctga accgcgccct gaccggaatc gcagtggagc aggacaagaa tacccaggag     2340

gtgttcgccc aggtgaagca gatctacaag acacccccta tcaaggactt tggcggcttc     2400

aactttagcc agatcctgcc tgatccatct aagcctagca agaggtcctt catcgaggac     2460

ctgctgttta ataaggtgac cctggccgat gccggcttca tcaagcagta tggcgattgc     2520

ctgggcgaca tcgcagcacg cgacctgatc tgtgcccaga agtttaacgg cctgacagtg     2580

ctgccacccc tgctgaccga tgagatgatc gcacagtaca cctctgccct gctggccgga     2640

accatcacaa gcggatggac attcggcgca ggagccgccc tgcagatccc attcgccatg     2700

cagatggcct atcggtttaa tggcatcggc gtgacccaga acgtgctgta cgagaatcag     2760

aagctgatcg ccaatcagtt taactccgcc atcggcaaga tccaggactc tctgtcctct     2820

accgccagcg ccctgggcaa gctgcaggat gtggtgaatc agaacgccca ggccctgaac     2880

acactggtga agcagctgag ctccaatttc ggcgccatct ctagcgtgct gaacgatatc     2940

ctgagcaggc tggacaaggt ggaggccgag gtgcagatcg accggctgat caccggcaga     3000

ctgcagtccc tgcagaccta cgtgacacag cagctgatca gggcagcaga gatcagggcc     3060

tctgccaacc tggcagcaac aaagatgagc gagtgcgtgc tgggacagtc caagagggtg     3120

gacttttgtg gcaagggcta tcacctgatg agcttcccac agtccgcccc acacggagtg     3180

gtgtttctgc acgtgaccta cgtgcctgcc caggagaaga atttcaccac agccccagcc     3240

atctgccacg atggcaaggc acacttccca agggagggcg tgtttgtgag caatggcaca     3300

cactggttcg tgacccagag aaacttttac gagcctcaga tcatcaccac agacaacacc     3360

ttcgtgagcg gcaattgtga cgtggtcatc ggcatcgtga acaatacagt gtatgatccc     3420

ctgcagcctg agctggactc tttcaaggag gagctggata agtactttaa gaaccacacc     3480

agccccgacg tggatctggg cgacatctcc ggcatcaacg cctctgtggt gaatatccag     3540

aaggagatcg acagactgaa tgaggtggcc aagaatctga acgagagcct gatcgacctg     3600

caggagctgg gcaagtatga gcagtacatc aagtggccat ggtatatctg gctgggcttc     3660

atcgccggcc tgatcgccat cgtgatggtg acaatcatgc tgtgctgtat gacctcttgc     3720

tgtagctgcc tgaagggctg ctgttcctgt ggctcttgct gtaagttcga tgaggacgat     3780

tccgagcccg tgctgaaggg cgtgaagctg cactacacag gctccggcgc caccaacttt     3840

tctctgctga agcaggcagg cgacgtggag gagaacccag gacctatggc cgatagcaat     3900

ggcaccatca cagtggagga gctgaagaag ctgctggagc agtggaacct ggtcatcggc     3960

ttcctgtttc tgacctggat ctgcctgctg cagttcgcct atgccaatcg gaacagattt     4020

ctgtacatca tcaagctgat cttcctgtgg ctgctgtggc cagtgaccct ggcctgcttc     4080

gtgctggccg ccgtgtatcg gatcaactgg atcacaggcg gcatcgccat cgccatggcc     4140

tgtctggtgg gcctgatgtg gctgagctac ttcatcgcct cctttagact gttcgccagg     4200

acccgcagca tgtggtcctt taatcccgag acaaacatcc tgctgaatgt gcctctgcac     4260

ggcaccatcc tgacaaggcc actgctggag tccgagctgg tcatcggagc cgtgatcctg     4320

aggggacacc tgagaatcgc aggacaccac ctgggccgct gcgatatcaa ggacctgcct     4380

aaggagatca ccgtggccac atctaggacc ctgagctact ataagctggg agccagccag     4440

agggtggcag gcgacagcgg attcgcagca tattcccggt acagaatcgg caactacaag     4500

ctgaataccg atcactcctc tagctccgac aatatcgccc tgctggtgca gggatctgga     4560

gcaacaaact tcagcctgct gaagcaggcc ggcgatgtgg aagaaaaccc aggacccatg     4620

tattcttttg tgagcgagga gacaggcaca ctgatcgtga atagcgtgct gctgtttctg     4680

gccttcgtgg tgtttctgct ggtgacactg gccatcctga ccgccctgag actgtgcgcc     4740

tactgctgta atatcgtgaa cgtgtctctg gtgaagccca gcttttacgt gtatagtagg     4800

gtgaagaatc tgaactcaag tagggtgccc gatctgctgg tctaa                     4845


<210>  15
<211>  7131
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  15
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acgggttcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      240

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      300

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtccgccccc      360

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttacg      420

ggactttcct acttggcagt acatctacgg tattagtcat cggctattac catggtgatg      480

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      540

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      600

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      660

gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc      720

tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc      780

attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag actctatagg      840

cacacccctt tggctcttat gcatgctata ctgtttttgg cttggggcct atacaccccc      900

gcttccttat gctataggtg atggtatagc ttagcctata ggtgtgggtt attgaccatt      960

attgaccact cccctattgg tgacgatact ttccattact aatccataac atggctcttt     1020

gccacaacta tctctattgg ctatatgcca atactctgtc cttcagagac tgacacggac     1080

tctgtatttt tacaggatgg ggtcccattt attatttaca aattcacata tacaacaacg     1140

ccgtcccccg tgcccgcagt ttttattaaa catagcgtgg gatctccacg cgaatctcgg     1200

gtaccgtgtt ccggacatgg gytcttctcc ggtagcggcg gagcttccac atccgagccc     1260

tggtcccatg cctccagcgg ctcatggtcg ctcggcagct ccttgctcct aacagtggag     1320

gccagactta ggcacagcac aatgcccacc accaccagtg tgccgcacaa ggccgtggcg     1380

gtagggtatg tgtctgaaaa tgagctcgga gattgggctc gcaccgctga cgcagatgga     1440

agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtatt ctgataagag     1500

tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta     1560

ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt     1620

tccatgggtc ttttctgcag tcaccatcga tatgttcgtg tttctggtct tgctgcccct     1680

ggtgtccagc cagtgcgtca acctgacaac cagaacccaa ctgcccccag cctacaccaa     1740

ctccttcaca agaggcgtgt attaccctga caaggtgttt cggagcagcg tgctgcactc     1800

cacccaggac ttgtttctgc ctttcttcag caacgtgacc tggttccacg ccatccacgt     1860

gagcggcacc aatggaacca agagattcga caatcctgtg ctccccttca acgacggcgt     1920

ctacttcgcc agcaccgaaa agtctaacat catcaggggc tggatcttcg gcacaacact     1980

ggacagcaag acccagtccc tgctgattgt gaacaacgcc acaaatgtgg tgatcaaggt     2040

gtgcgaattc cagttttgca acgatccctt tttgggcgtg tattaccaca agaacaacaa     2100

gagctggatg gaaagcgaat tccgggtgta cagcagcgcc aacaactgta ccttcgaata     2160

cgtgagccag cctttcctga tggacctgga aggcaaacag ggcaacttca agaacctgcg     2220

ggaattcgtg ttcaagaaca tcgacgggta cttcaagatc tactctaagc acacccctat     2280

caacctggtc agagacctgc ctcaaggctt tagcgccctg gaacctctgg tggacctgcc     2340

gatcggcatt aacatcacca gattccagac actgctggct ctgcacagat cctacctgac     2400

ccctggcgat agctccagcg gctggaccgc cggagctgct gcttactacg tgggctacct     2460

gcaaccaaga acctttctgc tgaagtacaa cgaaaacggc accatcacag acgccgtgga     2520

ctgcgccctg gatcctctca gcgagacaaa gtgtaccctc aagtcgttca ccgtggaaaa     2580

gggcatatac cagacctcta acttcagagt gcagcctaca gagagcatcg taagattccc     2640

taacatcacc aacctctgtc cctttggcga ggttttcaac gccaccagat tcgccagcgt     2700

atacgcctgg aacagaaaga gaatctccaa ttgcgtggcc gactacagcg tgctgtacaa     2760

ttctgcatct tttagcacat tcaaatgcta cggcgtgtcc ccaaccaagc taaacgacct     2820

gtgcttcacc aacgtctacg ccgactcatt tgtgattcgg ggcgacgaag tgcgccagat     2880

cgcccctggc cagaccggca aaatcgccga ttacaactac aagctgccag atgacttcac     2940

cggctgtgtg atcgcctgga acagcaataa tctggacagc aaggttggag gaaactacaa     3000

ctacctgtat cggctgttca gaaagagcaa cctgaagcct ttcgagcggg acatcagtac     3060

agagatctac caggctggct ccacgccatg caatggcgtg gagggcttca actgctactt     3120

ccccctgcag agctatggct tccagcccac aaacggcgtg ggctaccagc cttacagagt     3180

ggtggtgctg agcttcgagc tgcttcatgc ccctgctaca gtctgcggcc ctaagaaaag     3240

caccaatctg gtgaaaaata aatgcgtgaa cttcaacttt aacggcctga ccggaactgg     3300

agtccttacc gagagcaaca agaagttcct gccttttcag cagttcggaa gagatatcgc     3360

cgacaccacc gatgccgtgc gggatcccca gaccctggag atcctggata tcaccccctg     3420

cagcttcggc ggcgtgtctg tgatcacgcc cggcaccaac accagcaacc aggtggccgt     3480

tctgtaccag gatgtgaatt gcaccgaggt gcctgtggcc atccacgccg atcagctgac     3540

acccacctgg cgggtgtata gcaccggatc taatgtgttc cagacaagag ccggatgtct     3600

gatcggagcc gaacacgtga acaatagcta cgagtgtgac atccctatcg gcgccggaat     3660

ctgcgccagc taccaaacac agactaacag ccctcggaga gccagaagcg tggcctctca     3720

gtcaatcatc gcctacacca tgagcctggg cgccgagaac agcgtggcct acagcaacaa     3780

cagcatcgcg attcctacca actttaccat cagcgttacg acagagatcc tgcctgtgag     3840

catgaccaaa acctccgtgg actgcacaat gtacatctgc ggcgacagca ccgagtgcag     3900

caacctgctg ctgcaatacg gaagcttctg cacccagctg aatcgggccc tgaccggcat     3960

cgccgttgaa caggacaaga acactcagga ggtgtttgcc caggtcaagc agatatacaa     4020

gacccctcct atcaaggact tcggcggatt taacttttct cagatcctgc ctgaccccag     4080

caaaccttcc aaaagaagct tcatcgaaga cctgctgttc aacaaggtga cactcgccga     4140

cgccggattt atcaagcagt acggcgattg cctgggagac atcgccgcta gagatctgat     4200

ctgcgcccaa aaattcaacg gcctgacagt gctgcctcca ctgctgacag acgagatgat     4260

cgcccaatac acctctgccc tgctggccgg aaccatcaca agcggctgga ccttcggcgc     4320

cggcgcagcc ctgcaaatcc ccttcgccat gcagatggct tatagattca atggcatcgg     4380

cgtcacacag aacgtgctgt acgagaatca gaagctgatc gccaaccagt tcaactctgc     4440

tatcggcaaa atccaggatt cactaagcag caccgcctca gccctgggca aactgcagga     4500

tgtggttaat cagaatgccc aggccctgaa cacactggtg aagcaactgt ccagcaattt     4560

cggggctatt agcagtgtgc tgaacgatat cctgagtagg ctggatccac ctgaggccga     4620

agtgcagatc gaccggctca tcacagggag actgcagtcc ctgcagacct acgtgaccca     4680

gcagctcatc agagctgctg agatacgggc ctctgctaat ctggccgcta ccaaaatgag     4740

cgagtgcgtg ctgggccagt ctaagcgggt agatttctgc ggcaagggct atcacctgat     4800

gagcttccca cagagcgctc cgcacggcgt agtgttctta catgtgacat acgtccctgc     4860

ccaggagaag aacttcacca cagctcctgc catctgtcac gatggcaagg cccacttccc     4920

cagagagggc gtgttcgtgt ccaacggcac ccactggttc gtgacgcagc ggaacttcta     4980

cgagcctcag attatcacaa cagacaacac cttcgtgtct ggaaattgcg acgttgtcat     5040

cggcatcgtc aacaacaccg tgtacgaccc actgcagcct gagctggaca gcttcaagga     5100

agagctggac aagtacttca agaaccacac cagccccgat gtggacctgg gcgacatcag     5160

cggaatcaac gcctctgtgg tgaacatcca gaaggaaatc gacagactga acgaggtggc     5220

caagaacctg aatgagtcac ttattgacct gcaggaactg ggcaaatacg aacagtacat     5280

caaatggccc tggtacatct ggctgggatt catcgctggc ctgatcgcca tcgtgatggt     5340

gacaatcatg ctgtgttgca tgacatcttg ttgtagctgc ctgaagggct gctgtagctg     5400

tggctcttgt tgcaagttcg acgaggacga cagcgagccc gtgctcaagg gagtgaagct     5460

gcactatacc taaaccatga tattcggcaa gcaggcatcg ccatgggtca cgacgagatc     5520

ctcgccgtcg ggcatgctcg ccttgagcct ggcgaacagt tcggctggcg cgagcccctg     5580

atgctcttcg tccagatcat cctgatcgac aagaccggct tccatccgag tacgtgctcg     5640

ctcgatgcga tgtttcgctt ggtggtcgaa tgggcaggta gccggatcaa gcgtatgcag     5700

ccgccgcatt gcatcagcca tgatggatac tttctcggca ggagcaaggt gagatgacag     5760

gagatcctgc cccggcactt cgcccaatag cagccagtcc cttcccgctt cagtgacaac     5820

gtcgagcaca gctgcgcaag gaacgcccgt cgtggccagc cacgatagcc gcgctgcctc     5880

gtcttgcagt tcattcaggg caccggacag gtcggtcttg acaaaaagaa ccgggcgccc     5940

ctgcgctgac agccggaaca cggcggcatc agagcagccg attgtctgtt gtgcccagtc     6000

atagccgaat agcctctcca cccaagcggc cggagaacct gcgtgcaatc catcttgttc     6060

aatcatgcga aacgatcctc atcctgtctc ttgatcagat cttgatcccc tgcgccatca     6120

gatccttggc ggcaagaaag ccatccagtt tactttgcag ggcttcccaa ccttaccaga     6180

gggcgcccca gctggcaatt ccggttcgct tgctgtccat aaaaccgccc agtctagcta     6240

tcgccatgta agcccactgc aagctacctg ctttctcttt gcgcttgcgt tttcccttgt     6300

ccagatagcc cagtagctga cattcatccg gggtcagcac cgtttctgcg gactggcttt     6360

ctacgtgaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     6420

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     6480

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     6540

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     6600

cagagcgcag ataccaaata ctgttcttct agtgtagccg tagttaggcc accacttcaa     6660

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     6720

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     6780

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     6840

cacccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt cccgaaggga     6900

gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc acgagggagc     6960

ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac ctctgacttg     7020

agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac gccagcaacg     7080

cggccctttt acggttcctg gccttttgct ggccttttgc tcacatgttg t              7131


<210>  16
<211>  3822
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  16
atgttcgtgt ttctggtctt gctgcccctg gtgtccagcc agtgcgtcaa cctgacaacc       60

agaacccaac tgcccccagc ctacaccaac tccttcacaa gaggcgtgta ttaccctgac      120

aaggtgtttc ggagcagcgt gctgcactcc acccaggact tgtttctgcc tttcttcagc      180

aacgtgacct ggttccacgc catccacgtg agcggcacca atggaaccaa gagattcgac      240

aatcctgtgc tccccttcaa cgacggcgtc tacttcgcca gcaccgaaaa gtctaacatc      300

atcaggggct ggatcttcgg cacaacactg gacagcaaga cccagtccct gctgattgtg      360

aacaacgcca caaatgtggt gatcaaggtg tgcgaattcc agttttgcaa cgatcccttt      420

ttgggcgtgt attaccacaa gaacaacaag agctggatgg aaagcgaatt ccgggtgtac      480

agcagcgcca acaactgtac cttcgaatac gtgagccagc ctttcctgat ggacctggaa      540

ggcaaacagg gcaacttcaa gaacctgcgg gaattcgtgt tcaagaacat cgacgggtac      600

ttcaagatct actctaagca cacccctatc aacctggtca gagacctgcc tcaaggcttt      660

agcgccctgg aacctctggt ggacctgccg atcggcatta acatcaccag attccagaca      720

ctgctggctc tgcacagatc ctacctgacc cctggcgata gctccagcgg ctggaccgcc      780

ggagctgctg cttactacgt gggctacctg caaccaagaa cctttctgct gaagtacaac      840

gaaaacggca ccatcacaga cgccgtggac tgcgccctgg atcctctcag cgagacaaag      900

tgtaccctca agtcgttcac cgtggaaaag ggcatatacc agacctctaa cttcagagtg      960

cagcctacag agagcatcgt aagattccct aacatcacca acctctgtcc ctttggcgag     1020

gttttcaacg ccaccagatt cgccagcgta tacgcctgga acagaaagag aatctccaat     1080

tgcgtggccg actacagcgt gctgtacaat tctgcatctt ttagcacatt caaatgctac     1140

ggcgtgtccc caaccaagct aaacgacctg tgcttcacca acgtctacgc cgactcattt     1200

gtgattcggg gcgacgaagt gcgccagatc gcccctggcc agaccggcaa aatcgccgat     1260

tacaactaca agctgccaga tgacttcacc ggctgtgtga tcgcctggaa cagcaataat     1320

ctggacagca aggttggagg aaactacaac tacctgtatc ggctgttcag aaagagcaac     1380

ctgaagcctt tcgagcggga catcagtaca gagatctacc aggctggctc cacgccatgc     1440

aatggcgtgg agggcttcaa ctgctacttc cccctgcaga gctatggctt ccagcccaca     1500

aacggcgtgg gctaccagcc ttacagagtg gtggtgctga gcttcgagct gcttcatgcc     1560

cctgctacag tctgcggccc taagaaaagc accaatctgg tgaaaaataa atgcgtgaac     1620

ttcaacttta acggcctgac cggaactgga gtccttaccg agagcaacaa gaagttcctg     1680

ccttttcagc agttcggaag agatatcgcc gacaccaccg atgccgtgcg ggatccccag     1740

accctggaga tcctggatat caccccctgc agcttcggcg gcgtgtctgt gatcacgccc     1800

ggcaccaaca ccagcaacca ggtggccgtt ctgtaccagg atgtgaattg caccgaggtg     1860

cctgtggcca tccacgccga tcagctgaca cccacctggc gggtgtatag caccggatct     1920

aatgtgttcc agacaagagc cggatgtctg atcggagccg aacacgtgaa caatagctac     1980

gagtgtgaca tccctatcgg cgccggaatc tgcgccagct accaaacaca gactaacagc     2040

cctcggagag ccagaagcgt ggcctctcag tcaatcatcg cctacaccat gagcctgggc     2100

gccgagaaca gcgtggccta cagcaacaac agcatcgcga ttcctaccaa ctttaccatc     2160

agcgttacga cagagatcct gcctgtgagc atgaccaaaa cctccgtgga ctgcacaatg     2220

tacatctgcg gcgacagcac cgagtgcagc aacctgctgc tgcaatacgg aagcttctgc     2280

acccagctga atcgggccct gaccggcatc gccgttgaac aggacaagaa cactcaggag     2340

gtgtttgccc aggtcaagca gatatacaag acccctccta tcaaggactt cggcggattt     2400

aacttttctc agatcctgcc tgaccccagc aaaccttcca aaagaagctt catcgaagac     2460

ctgctgttca acaaggtgac actcgccgac gccggattta tcaagcagta cggcgattgc     2520

ctgggagaca tcgccgctag agatctgatc tgcgcccaaa aattcaacgg cctgacagtg     2580

ctgcctccac tgctgacaga cgagatgatc gcccaataca cctctgccct gctggccgga     2640

accatcacaa gcggctggac cttcggcgcc ggcgcagccc tgcaaatccc cttcgccatg     2700

cagatggctt atagattcaa tggcatcggc gtcacacaga acgtgctgta cgagaatcag     2760

aagctgatcg ccaaccagtt caactctgct atcggcaaaa tccaggattc actaagcagc     2820

accgcctcag ccctgggcaa actgcaggat gtggttaatc agaatgccca ggccctgaac     2880

acactggtga agcaactgtc cagcaatttc ggggctatta gcagtgtgct gaacgatatc     2940

ctgagtaggc tggatccacc tgaggccgaa gtgcagatcg accggctcat cacagggaga     3000

ctgcagtccc tgcagaccta cgtgacccag cagctcatca gagctgctga gatacgggcc     3060

tctgctaatc tggccgctac caaaatgagc gagtgcgtgc tgggccagtc taagcgggta     3120

gatttctgcg gcaagggcta tcacctgatg agcttcccac agagcgctcc gcacggcgta     3180

gtgttcttac atgtgacata cgtccctgcc caggagaaga acttcaccac agctcctgcc     3240

atctgtcacg atggcaaggc ccacttcccc agagagggcg tgttcgtgtc caacggcacc     3300

cactggttcg tgacgcagcg gaacttctac gagcctcaga ttatcacaac agacaacacc     3360

ttcgtgtctg gaaattgcga cgttgtcatc ggcatcgtca acaacaccgt gtacgaccca     3420

ctgcagcctg agctggacag cttcaaggaa gagctggaca agtacttcaa gaaccacacc     3480

agccccgatg tggacctggg cgacatcagc ggaatcaacg cctctgtggt gaacatccag     3540

aaggaaatcg acagactgaa cgaggtggcc aagaacctga atgagtcact tattgacctg     3600

caggaactgg gcaaatacga acagtacatc aaatggccct ggtacatctg gctgggattc     3660

atcgctggcc tgatcgccat cgtgatggtg acaatcatgc tgtgttgcat gacatcttgt     3720

tgtagctgcc tgaagggctg ctgtagctgt ggctcttgtt gcaagttcga cgaggacgac     3780

agcgagcccg tgctcaaggg agtgaagctg cactatacct aa                        3822


<210>  17
<211>  7038
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  17
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acgggttcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      240

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      300

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtccgccccc      360

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttacg      420

ggactttcct acttggcagt acatctacgg tattagtcat cggctattac catggtgatg      480

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      540

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      600

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      660

gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc      720

tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc      780

attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag actctatagg      840

cacacccctt tggctcttat gcatgctata ctgtttttgg cttggggcct atacaccccc      900

gcttccttat gctataggtg atggtatagc ttagcctata ggtgtgggtt attgaccatt      960

attgaccact cccctattgg tgacgatact ttccattact aatccataac atggctcttt     1020

gccacaacta tctctattgg ctatatgcca atactctgtc cttcagagac tgacacggac     1080

tctgtatttt tacaggatgg ggtcccattt attatttaca aattcacata tacaacaacg     1140

ccgtcccccg tgcccgcagt ttttattaaa catagcgtgg gatctccacg cgaatctcgg     1200

gtaccgtgtt ccggacatgg gytcttctcc ggtagcggcg gagcttccac atccgagccc     1260

tggtcccatg cctccagcgg ctcatggtcg ctcggcagct ccttgctcct aacagtggag     1320

gccagactta ggcacagcac aatgcccacc accaccagtg tgccgcacaa ggccgtggcg     1380

gtagggtatg tgtctgaaaa tgagctcgga gattgggctc gcaccgctga cgcagatgga     1440

agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtatt ctgataagag     1500

tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta     1560

ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt     1620

tccatgggtc ttttctgcag tcaccatcga tatgtggctg cagggcctgc tgctgctggg     1680

caccgtggca tgcagtatca gccaatgtgt gaacctgacc accagaaccc aactgcctcc     1740

tgcctacacc aactctttca ccagaggcgt gtactaccct gacaaggtgt tcagaagcag     1800

cgtgctgcat tctacccagg acctgtttct gccattcttc agcaacgtca cctggttcca     1860

cgccatccac gtgtctggca ccaatggcac taagagattc gacaaccccg tgctgccttt     1920

caacgacggc gtgtactttg cctcaactga gaagagcaac atcatcagag gatggatctt     1980

cggcaccaca cttgactcaa agacacagtc actgctgatc gtgaacaatg ctaccaatgt     2040

ggtgatcaag gtgtgtgaat tccagttttg caacgatcct ttcctgggtg tatactacca     2100

caagaacaac aagtcttgga tggagagcga gttccgggtg tatagtagcg ccaacaactg     2160

caccttcgaa tacgtgagcc agcctttcct catggacctg gaaggcaagc aaggcaactt     2220

caagaacctg agagagttcg tgtttaagaa cattgatggc tacttcaaga tctacagcaa     2280

gcacaccccc atcaacctgg tgcgggacct ccctcagggc ttcagcgccc tggaaccctt     2340

ggttgatctg ccaattggca tcaatatcac tcggttccaa accctgctgg ccctgcacag     2400

aagctatctg acacctggag acagcagcag cggctggacc gccggagccg ccgcctacta     2460

cgtgggctac ctgcagcccc ggaccttcct gctgaagtac aacgagaacg ggaccattac     2520

cgacgccgtc gactgcgccc tggatcctct gagcgaaacc aagtgcacac ttaaaagctt     2580

cacagtggag aagggcatct accaaacctc caattttcgg gtccagccaa ccgagagcat     2640

cgttagattc cccaacatca ccaacttgtg ccccttcgga gaagtgttca acgccacaag     2700

attcgccagc gtctacgcct ggaacagaaa gagaatttcc aattgcgtcg cagactactc     2760

tgtgctgtac aacagcgcca gcttttctac attcaagtgc tacggcgtga gccccaccaa     2820

gctgaacgac ctatgcttca caaacgtgta cgccgacagc tttgtgatcc ggggcgacga     2880

ggtgcgccag atcgcgccag gacagaccgg taagatcgcc gattacaatt acaaactgcc     2940

tgacgacttc accggctgcg tcatcgcttg gaacagcaac aacctggact ctaaggtggg     3000

cggaaactac aactacctgt accggctgtt tagaaagagc aacctgaagc cttttgaacg     3060

ggacatctct acagagatct accaggccgg atctacccct tgtaatggcg tggagggctt     3120

taattgctac ttccccctgc aatcgtacgg cttccagccg acaaacggcg tcggctacca     3180

gccttacaga gtggtggtcc tgtccttcga gctgctgcat gcccctgcta cagtgtgcgg     3240

ccctaagaaa agcaccaacc tggtgaagaa caagtgtgtg aacttcaatt tcaatggcct     3300

gactggcacc ggagtgctga ccgaatccaa caagaagttc ctgcccttcc agcagttcgg     3360

cagagacatc gcagacacta ccgatgctgt gcgggatcct cagacactgg agatcctgga     3420

tatcaccccc tgcagcttcg gaggcgtgag cgtgatcaca cctggcacaa acacatccaa     3480

ccaggtggcc gtgctgtacc aggatgtgaa ctgcacagaa gtgccggttg ccatccacgc     3540

cgatcagctc acacctactt ggcgggtgta ctccacaggc agcaacgtgt tccaaaccag     3600

agctggctgt ctgatcggcg ctgaacacgt gaacaatagc tatgagtgcg acatcccaat     3660

cggcgccggt atctgcgcct cctatcagac gcagacgaac agccctaggc gggctagaag     3720

cgtggccagc cagagcatca tcgcatatac aatgagcctg ggcgccgaaa actctgtcgc     3780

ctacagcaac aacagcatcg ctatccctac caacttcacc ataagcgtaa caaccgagat     3840

cctgcctgtg tccatgacaa agaccagcgt ggactgtaca atgtacatct gtggcgactc     3900

caccgagtgc agcaacctgc tcctgcaata cggctctttc tgcacccagc tgaatcgcgc     3960

cttaacaggc attgccgtgg aacaggataa gaacacccag gaggtgttcg cccaggtgaa     4020

gcagatctat aagaccccac ccatcaagga cttcggcgga ttcaatttca gtcaaatcct     4080

gcccgatcct agcaagccca gtaagagatc tttcatcgag gacctgcttt tcaacaaagt     4140

gaccctggcg gacgccggat ttatcaaaca gtacggcgac tgtctgggcg acatcgccgc     4200

tagagatctg atctgcgccc agaaattcaa cggcctgacg gtgctgcctc ctctgctgac     4260

agatgagatg atcgcccagt ataccagcgc cctgctggct ggaaccatca cctctggctg     4320

gacatttggc gccggtgccg ctctccagat cccctttgcc atgcagatgg cctacagatt     4380

caatggaatc ggcgtgaccc agaacgtgct gtacgagaac cagaagctga tcgctaatca     4440

gttcaactct gccattggca aaatccagga cagcctgtct tccaccgcca gcgccctggg     4500

caaactgcaa gacgtggtga atcaaaacgc ccaggccctg aacactctgg tgaagcagct     4560

gtccagcaac ttcggagcca tcagcagcgt gctgaacgac atactgagca gactggaccc     4620

tccggaggcc gaggtgcaga tcgacaggct gatcacaggc agactgcaga gcctgcagac     4680

ctacgtcaca cagcagctga tcagagccgc tgagatccga gcttctgcca atctcgccgc     4740

gacaaagatg tctgagtgcg tgctcggcca gagcaaaaga gtggatttct gcggaaaagg     4800

ctatcacctg atgagcttcc ctcagtctgc cccacacggc gtcgtgttcc tgcacgtgac     4860

ctacgtgcct gcccaggaaa aaaactttac caccgccccg gccatctgcc acgacggcaa     4920

ggcccacttc cctagagaag gcgtgttcgt gagcaatggc acccactggt tcgtgacaca     4980

aagaaacttc tacgagcctc aaatcatcac aacagataac accttcgtgt caggcaactg     5040

tgacgtggtc atcggaatcg tgaataatac cgtgtacgac cccctgcagc ctgaactgga     5100

cagctttaag gaggaactgg acaagtactt caaaaaccac acatctcctg atgtggacct     5160

gggggatatc agcggcatca acgcttctgt ggtgaacatc cagaaggaaa tcgacagact     5220

gaacgaggtg gccaagaatc tcaacgaaag cctcattgac cttcaggagc tggggaagta     5280

cgagcagggc tctgccggct acatccctga ggctcctagg gacggccagg cctacgtgcg     5340

gaaggacggg gagtgggtgc tgctgagcac attcctgtaa accatgatat tcggcaagca     5400

ggcatcgcca tgggtcacga cgagatcctc gccgtcgggc atgctcgcct tgagcctggc     5460

gaacagttcg gctggcgcga gcccctgatg ctcttcgtcc agatcatcct gatcgacaag     5520

accggcttcc atccgagtac gtgctcgctc gatgcgatgt ttcgcttggt ggtcgaatgg     5580

gcaggtagcc ggatcaagcg tatgcagccg ccgcattgca tcagccatga tggatacttt     5640

ctcggcagga gcaaggtgag atgacaggag atcctgcccc ggcacttcgc ccaatagcag     5700

ccagtccctt cccgcttcag tgacaacgtc gagcacagct gcgcaaggaa cgcccgtcgt     5760

ggccagccac gatagccgcg ctgcctcgtc ttgcagttca ttcagggcac cggacaggtc     5820

ggtcttgaca aaaagaaccg ggcgcccctg cgctgacagc cggaacacgg cggcatcaga     5880

gcagccgatt gtctgttgtg cccagtcata gccgaatagc ctctccaccc aagcggccgg     5940

agaacctgcg tgcaatccat cttgttcaat catgcgaaac gatcctcatc ctgtctcttg     6000

atcagatctt gatcccctgc gccatcagat ccttggcggc aagaaagcca tccagtttac     6060

tttgcagggc ttcccaacct taccagaggg cgccccagct ggcaattccg gttcgcttgc     6120

tgtccataaa accgcccagt ctagctatcg ccatgtaagc ccactgcaag ctacctgctt     6180

tctctttgcg cttgcgtttt cccttgtcca gatagcccag tagctgacat tcatccgggg     6240

tcagcaccgt ttctgcggac tggctttcta cgtgaaaagg atctaggtga agatcctttt     6300

tgataatctc atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc     6360

cgtagaaaag atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt     6420

gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac     6480

tctttttccg aaggtaactg gcttcagcag agcgcagata ccaaatactg ttcttctagt     6540

gtagccgtag ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct     6600

gctaatcctg ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga     6660

ctcaagacga tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac     6720

acagcccagc ttggagcgaa cgacctacac ccgaactgag atacctacag cgtgagctat     6780

gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta agcggcaggg     6840

tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat ctttatagtc     6900

ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg tcaggggggc     6960

ggagcctatg gaaaaacgcc agcaacgcgg cccttttacg gttcctggcc ttttgctggc     7020

cttttgctca catgttgt                                                   7038


<210>  18
<211>  3722
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  18
atgtggctgc agggcctgct gctgctgggc accgtggcat gcagtatcag ccaatgtgtg       60

aacctgacca ccagaaccca actgcctcct gcctacacca actctttcac cagaggcgtg      120

tactaccctg acaaggtgtt cagaagcagc gtgctgcatt ctacccagga cctgtttctg      180

ccattcttca gcaacgtcac ctggttccac gccatccacg tgtctggcac caatggcact      240

aagagattcg acaaccccgt gctgcctttc aacgacggcg tgtactttgc ctcaactgag      300

aagagcaaca tcatcagagg atggatcttc ggcaccacac ttgactcaaa gacacagtca      360

ctgctgatcg tgaacaatgc taccaatgtg gtgatcaagg tgtgtgaatt ccagttttgc      420

aacgatcctt tcctgggtgt atactaccac aagaacaaca agtcttggat ggagagcgag      480

ttccgggtgt atagtagcgc caacaactgc accttcgaat acgtgagcca gcctttcctc      540

atggacctgg aaggcaagca aggcaacttc aagaacctga gagagttcgt gtttaagaac      600

attgatggct acttcaagat ctacagcaag cacaccccca tcaacctggt gcgggacctc      660

cctcagggct tcagcgccct ggaacccttg gttgatctgc caattggcat caatatcact      720

cggttccaaa ccctgctggc cctgcacaga agctatctga cacctggaga cagcagcagc      780

ggctggaccg ccggagccgc cgcctactac gtgggctacc tgcagccccg gaccttcctg      840

ctgaagtaca acgagaacgg gaccattacc gacgccgtcg actgcgccct ggatcctctg      900

agcgaaacca agtgcacact taaaagcttc acagtggaga agggcatcta ccaaacctcc      960

aattttcggg tccagccaac cgagagcatc gttagattcc ccaacatcac caacttgtgc     1020

cccttcggag aagtgttcaa cgccacaaga ttcgccagcg tctacgcctg gaacagaaag     1080

agaatttcca attgcgtcgc agactactct gtgctgtaca acagcgccag cttttctaca     1140

ttcaagtgct acggcgtgag ccccaccaag ctgaacgacc tatgcttcac aaacgtgtac     1200

gccgacagct ttgtgatccg gggcgacgag gtgcgccaga tcgcgccagg acagaccggt     1260

aagatcgccg attacaatta caaactgcct gacgacttca ccggctgcgt catcgcttgg     1320

aacagcaaca acctggactc taaggtgggc ggaaactaca actacctgta ccggctgttt     1380

agaaagagca acctgaagcc ttttgaacgg gacatctcta cagagatcta ccaggccgga     1440

tctacccctt gtaatggcgt ggagggcttt aattgctact tccccctgca atcgtacggc     1500

ttccagccga caaacggcgt cggctaccag ccttacagag tggtggtcct gtccttcgag     1560

ctgctgcatg cccctgctac agtgtgcggc cctaagaaaa gcaccaacct ggtgaagaac     1620

aagtgtgtga acttcaattt caatggcctg actggcaccg gagtgctgac cgaatccaac     1680

aagaagttcc tgcccttcca gcagttcggc agagacatcg cagacactac cgatgctgtg     1740

cgggatcctc agacactgga gatcctggat atcaccccct gcagcttcgg aggcgtgagc     1800

gtgatcacac ctggcacaaa cacatccaac caggtggccg tgctgtacca ggatgtgaac     1860

tgcacagaag tgccggttgc catccacgcc gatcagctca cacctacttg gcgggtgtac     1920

tccacaggca gcaacgtgtt ccaaaccaga gctggctgtc tgatcggcgc tgaacacgtg     1980

aacaatagct atgagtgcga catcccaatc ggcgccggta tctgcgcctc ctatcagacg     2040

cagacgaaca gccctaggcg ggctagaagc gtggccagcc agagcatcat cgcatataca     2100

atgagcctgg gcgccgaaaa ctctgtcgcc tacagcaaca acagcatcgc tatccctacc     2160

aacttcacca taagcgtaac aaccgagatc ctgcctgtgt ccatgacaaa gaccagcgtg     2220

gactgtacaa tgtacatctg tggcgactcc accgagtgca gcaacctgct cctgcaatac     2280

ggctctttct gcacccagct gaatcgcgcc ttaacaggca ttgccgtgga acaggataag     2340

aacacccagg aggtgttcgc ccaggtgaag cagatctata agaccccacc catcaaggac     2400

ttcggcggat tcaatttcag tcaaatcctg cccgatccta gcaagcccag taagagatct     2460

ttcatcgagg acctgctttt caacaaagtg accctggcgg acgccggatt tatcaaacag     2520

tacggcgact gtctgggcga catcgccgct agagatctga tctgcgccca gaaattcaac     2580

ggcctgacgg tgctgcctcc tctgctgaca gatgagatga tcgcccagta taccagcgcc     2640

ctgctggctg gaaccatcac ctctggctgg acatttggcg ccggtgccgc tctccagatc     2700

ccctttgcca tgcagatggc ctacagattc aatggaatcg gcgtgaccca gaacgtgctg     2760

tacgagaacc agaagctgat cgctaatcag ttcaactctg ccattggcaa aatccaggac     2820

agcctgtctt ccaccgccag cgccctgggc aaactgcaag acgtggtgaa tcaaaacgcc     2880

caggccctga acactctggt gaagcagctg tccagcaact tcggagccat cagcagcgtg     2940

ctgaacgaca tactgagcag actggaccct ccggaggccg aggtgcagat cgacaggctg     3000

atcacaggca gactgcagag cctgcagacc tacgtcacac agcagctgat cagagccgct     3060

gagatccgag cttctgccaa tctcgccgcg acaaagatgt ctgagtgcgt gctcggccag     3120

agcaaaagag tggatttctg cggaaaaggc tatcacctga tgagcttccc tcagtctgcc     3180

ccacacggcg tcgtgttcct gcacgtgacc tacgtgcctg cccaggaaaa aaactttacc     3240

accgccccgg ccatctgcca cgacggcaag gcccacttcc ctagagaagg cgtgttcgtg     3300

agcaatggca cccactggtt cgtgacacaa agaaacttct acgagcctca aatcatcaca     3360

acagataaca ccttcgtgtc aggcaactgt gacgtggtca tcggaatcgt gaataatacc     3420

gtgtacgacc ccctgcagcc tgaactggac agctttaagg aggaactgga caagtacttc     3480

aaaaaccaca catctcctga tgtggacctg ggggatatca gcggcatcaa cgcttctgtg     3540

gtgaacatcc agaaggaaat cgacagactg aacgaggtgg ccaagaatct caacgaaagc     3600

ctcattgacc ttcaggagct ggggaagtac gagcagggct ctgccggcta catccctgag     3660

gctcctaggg acggccaggc ctacgtgcgg aaggacgggg agtgggtgct gctgagcaca     3720

tt                                                                    3722


<210>  19
<211>  5664
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  19
cgacaatatt ggctattggc cattgcatac gttgtatcta tatcataata tgtacattta       60

tattggctca tgtccaatat gaccgccatg ttgacattga ttattgacta gttattaata      120

gtaatcaatt acgggttcat tagttcatag cccatatatg gagttccgcg ttacataact      180

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      240

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      300

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtccgccccc      360

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttacg      420

ggactttcct acttggcagt acatctacgg tattagtcat cggctattac catggtgatg      480

cggttttggc agtacaccaa tgggcgtgga tagcggtttg actcacgggg atttccaagt      540

ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg ggactttcca      600

aaatgtcgta ataaccccgc cccgttgacg caaatgggcg gtaggcgtgt acggtgggag      660

gtctatataa gcagagctcg tttagtgaac cgtcagatcg cctggagacg ccatccacgc      720

tgttttgacc tccatagaag acaccgggac cgatccagcc tccgcggccg ggaacggtgc      780

attggaacgc ggattccccg tgccaagagt gacgtaagta ccgcctatag actctatagg      840

cacacccctt tggctcttat gcatgctata ctgtttttgg cttggggcct atacaccccc      900

gcttccttat gctataggtg atggtatagc ttagcctata ggtgtgggtt attgaccatt      960

attgaccact cccctattgg tgacgatact ttccattact aatccataac atggctcttt     1020

gccacaacta tctctattgg ctatatgcca atactctgtc cttcagagac tgacacggac     1080

tctgtatttt tacaggatgg ggtcccattt attatttaca aattcacata tacaacaacg     1140

ccgtcccccg tgcccgcagt ttttattaaa catagcgtgg gatctccacg cgaatctcgg     1200

gtaccgtgtt ccggacatgg gytcttctcc ggtagcggcg gagcttccac atccgagccc     1260

tggtcccatg cctccagcgg ctcatggtcg ctcggcagct ccttgctcct aacagtggag     1320

gccagactta ggcacagcac aatgcccacc accaccagtg tgccgcacaa ggccgtggcg     1380

gtagggtatg tgtctgaaaa tgagctcgga gattgggctc gcaccgctga cgcagatgga     1440

agacttaagg cagcggcaga agaagatgca ggcagctgag ttgttgtatt ctgataagag     1500

tcagaggtaa ctcccgttgc ggtgctgtta acggtggagg gcagtgtagt ctgagcagta     1560

ctcgttgctg ccgcgcgcgc caccagacat aatagctgac agactaacag actgttcctt     1620

tccatgggtc ttttctgcag tcaccatcga tatgtggctg caggggctgc tgctgctggg     1680

aaccgtggct tgctccattt ctcagtgcgt caatctgact acccgaactc agctgccccc     1740

cgcctacacc aactccttca cccggggcgt gtactatcca gacaaggtgt ttagaagctc     1800

cgtgctgcac tccacccagg atctgtttct gcccttcttt tctaatgtga catggttcca     1860

cgccatccac gtgagcggca ccaacggcac aaagaggttc gacaaccctg tgctgccatt     1920

caatgatggc gtgtactttg cctccaccga gaagtctaac atcatccgcg gctggatctt     1980

tggcaccaca ctggactcca agacccagtc cctgctgatc gtgaacaatg ccacaaacgt     2040

ggtcatcaag gtgtgcgagt tccagttttg taacgatcct ttcctgggcg tgtactatca     2100

caagaacaat aagtcttgga tggagagcga gtttagggtg tattctagcg ccaacaattg     2160

caccttcgag tacgtgtccc agccatttct gatggacctg gagggcaagc agggcaattt     2220

caagaacctg cgggagttcg tgtttaagaa catcgacggc tacttcaaga tctactccaa     2280

gcacaccccc atcaacctgg tgcgggacct gccacagggc ttctctgccc tggagcctct     2340

ggtggatctg ccaatcggca tcaacatcac acggtttcag accctgctgg ccctgcacag     2400

aagctacctg acccctggcg actcctctag cggatggaca gcaggagcag cagcatacta     2460

tgtgggctat ctgcagccac ggaccttcct gctgaagtac aacgagaatg gcaccatcac     2520

agacgccgtg gattgcgccc tggatccact gtctgagaca aagtgtacac tgaagagctt     2580

tacagtggag aagggcatct atcagaccag caacttcagg gtgcagccca cagagtccat     2640

cgtgcgcttt ccaaatatca ccaacctgtg ccccttcggc gaggtgttta atgccacaag     2700

attcgccagc gtgtacgcct ggaacaggaa gcgcatctcc aattgcgtgg ccgactattc     2760

tgtgctgtac aactctgcca gcttctccac ctttaagtgc tatggcgtga gccccaccaa     2820

gctgaacgac ctgtgcttca caaacgtgta cgccgattcc tttgtgatca ggggcgacga     2880

ggtgcgccag atcgcaccag gacagaccgg caagatcgca gactacaact ataagctgcc     2940

cgacgatttc acaggctgcg tgatcgcctg gaattccaac aatctggatt ctaaagtggg     3000

cggcaactac aattatctgt acaggctgtt ccgcaagtct aacctgaagc cttttgagcg     3060

ggacatctcc accgagatct accaggccgg ctctacacca tgcaacggcg tggagggctt     3120

caattgttat tttcccctgc agagctacgg cttccagcct accaatggcg tgggctatca     3180

gccatacaga gtggtggtgc tgtcttttga gctgctgcac gcaccagcaa ccgtgtgcgg     3240

acctaagaag agcacaaatc tggtgaagaa caagtgcgtg aacttcaact tcaacggcct     3300

gaccggaaca ggcgtgctga ccgagtccaa caagaagttc ctgccctttc agcagttcgg     3360

cagggacatc gcagatacca cagacgccgt gcgcgacccc cagacactgg agatcctgga     3420

tatcacccct tgcagcttcg gcggcgtgtc cgtgatcacc cctggaacca atacaagcaa     3480

ccaggtggcc gtgctgtatc aggacgtgaa ctgtacagag gtgccagtgg ccatccacgc     3540

cgatcagctg acccccacat ggcgggtgta ctccacaggc tctaacgtgt tccagaccag     3600

agcaggatgc ctgatcggag cagagcacgt gaacaatagc tatgagtgcg acatccccat     3660

cggcgccggc atctgtgcct cctaccagac ccagacaaac tcccctcgga gagccaggtc     3720

tgtggcctct cagagcatca tcgcctatac catgagcctg ggcgccgaga actccgtggc     3780

ctacagcaac aattccatcg ccatccccac caatttcaca atctccgtga ccacagagat     3840

cctgcccgtg agcatgacca agacaagcgt ggactgcacc atgtatatct gtggcgattc     3900

cacagagtgc tctaatctgc tgctgcagta cggctctttt tgtacacagc tgaaccgcgc     3960

cctgaccgga atcgcagtgg agcaggacaa gaatacccag gagtaaacca tgatattcgg     4020

caagcaggca tcgccatggg tcacgacgag atcctcgccg tcgggcatgc tcgccttgag     4080

cctggcgaac agttcggctg gcgcgagccc ctgatgctct tcgtccagat catcctgatc     4140

gacaagaccg gcttccatcc gagtacgtgc tcgctcgatg cgatgtttcg cttggtggtc     4200

gaatgggcag gtagccggat caagcgtatg cagccgccgc attgcatcag ccatgatgga     4260

tactttctcg gcaggagcaa ggtgagatga caggagatcc tgccccggca cttcgcccaa     4320

tagcagccag tcccttcccg cttcagtgac aacgtcgagc acagctgcgc aaggaacgcc     4380

cgtcgtggcc agccacgata gccgcgctgc ctcgtcttgc agttcattca gggcaccgga     4440

caggtcggtc ttgacaaaaa gaaccgggcg cccctgcgct gacagccgga acacggcggc     4500

atcagagcag ccgattgtct gttgtgccca gtcatagccg aatagcctct ccacccaagc     4560

ggccggagaa cctgcgtgca atccatcttg ttcaatcatg cgaaacgatc ctcatcctgt     4620

ctcttgatca gatcttgatc ccctgcgcca tcagatcctt ggcggcaaga aagccatcca     4680

gtttactttg cagggcttcc caaccttacc agagggcgcc ccagctggca attccggttc     4740

gcttgctgtc cataaaaccg cccagtctag ctatcgccat gtaagcccac tgcaagctac     4800

ctgctttctc tttgcgcttg cgttttccct tgtccagata gcccagtagc tgacattcat     4860

ccggggtcag caccgtttct gcggactggc tttctacgtg aaaaggatct aggtgaagat     4920

cctttttgat aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc     4980

agaccccgta gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg     5040

ctgcttgcaa acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct     5100

accaactctt tttccgaagg taactggctt cagcagagcg cagataccaa atactgttct     5160

tctagtgtag ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct     5220

cgctctgcta atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg     5280

gttggactca agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc     5340

gtgcacacag cccagcttgg agcgaacgac ctacacccga actgagatac ctacagcgtg     5400

agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg     5460

gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc tggtatcttt     5520

atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga tgctcgtcag     5580

gggggcggag cctatggaaa aacgccagca acgcggccct tttacggttc ctggcctttt     5640

gctggccttt tgctcacatg ttgt                                            5664


<210>  20
<211>  2355
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  20
atgtggctgc aggggctgct gctgctggga accgtggctt gctccatttc tcagtgcgtc       60

aatctgacta cccgaactca gctgcccccc gcctacacca actccttcac ccggggcgtg      120

tactatccag acaaggtgtt tagaagctcc gtgctgcact ccacccagga tctgtttctg      180

cccttctttt ctaatgtgac atggttccac gccatccacg tgagcggcac caacggcaca      240

aagaggttcg acaaccctgt gctgccattc aatgatggcg tgtactttgc ctccaccgag      300

aagtctaaca tcatccgcgg ctggatcttt ggcaccacac tggactccaa gacccagtcc      360

ctgctgatcg tgaacaatgc cacaaacgtg gtcatcaagg tgtgcgagtt ccagttttgt      420

aacgatcctt tcctgggcgt gtactatcac aagaacaata agtcttggat ggagagcgag      480

tttagggtgt attctagcgc caacaattgc accttcgagt acgtgtccca gccatttctg      540

atggacctgg agggcaagca gggcaatttc aagaacctgc gggagttcgt gtttaagaac      600

atcgacggct acttcaagat ctactccaag cacaccccca tcaacctggt gcgggacctg      660

ccacagggct tctctgccct ggagcctctg gtggatctgc caatcggcat caacatcaca      720

cggtttcaga ccctgctggc cctgcacaga agctacctga cccctggcga ctcctctagc      780

ggatggacag caggagcagc agcatactat gtgggctatc tgcagccacg gaccttcctg      840

ctgaagtaca acgagaatgg caccatcaca gacgccgtgg attgcgccct ggatccactg      900

tctgagacaa agtgtacact gaagagcttt acagtggaga agggcatcta tcagaccagc      960

aacttcaggg tgcagcccac agagtccatc gtgcgctttc caaatatcac caacctgtgc     1020

cccttcggcg aggtgtttaa tgccacaaga ttcgccagcg tgtacgcctg gaacaggaag     1080

cgcatctcca attgcgtggc cgactattct gtgctgtaca actctgccag cttctccacc     1140

tttaagtgct atggcgtgag ccccaccaag ctgaacgacc tgtgcttcac aaacgtgtac     1200

gccgattcct ttgtgatcag gggcgacgag gtgcgccaga tcgcaccagg acagaccggc     1260

aagatcgcag actacaacta taagctgccc gacgatttca caggctgcgt gatcgcctgg     1320

aattccaaca atctggattc taaagtgggc ggcaactaca attatctgta caggctgttc     1380

cgcaagtcta acctgaagcc ttttgagcgg gacatctcca ccgagatcta ccaggccggc     1440

tctacaccat gcaacggcgt ggagggcttc aattgttatt ttcccctgca gagctacggc     1500

ttccagccta ccaatggcgt gggctatcag ccatacagag tggtggtgct gtcttttgag     1560

ctgctgcacg caccagcaac cgtgtgcgga cctaagaaga gcacaaatct ggtgaagaac     1620

aagtgcgtga acttcaactt caacggcctg accggaacag gcgtgctgac cgagtccaac     1680

aagaagttcc tgccctttca gcagttcggc agggacatcg cagataccac agacgccgtg     1740

cgcgaccccc agacactgga gatcctggat atcacccctt gcagcttcgg cggcgtgtcc     1800

gtgatcaccc ctggaaccaa tacaagcaac caggtggccg tgctgtatca ggacgtgaac     1860

tgtacagagg tgccagtggc catccacgcc gatcagctga cccccacatg gcgggtgtac     1920

tccacaggct ctaacgtgtt ccagaccaga gcaggatgcc tgatcggagc agagcacgtg     1980

aacaatagct atgagtgcga catccccatc ggcgccggca tctgtgcctc ctaccagacc     2040

cagacaaact cccctcggag agccaggtct gtggcctctc agagcatcat cgcctatacc     2100

atgagcctgg gcgccgagaa ctccgtggcc tacagcaaca attccatcgc catccccacc     2160

aatttcacaa tctccgtgac cacagagatc ctgcccgtga gcatgaccaa gacaagcgtg     2220

gactgcacca tgtatatctg tggcgattcc acagagtgct ctaatctgct gctgcagtac     2280

ggctcttttt gtacacagct gaaccgcgcc ctgaccggaa tcgcagtgga gcaggacaag     2340

aatacccagg agtaa                                                      2355


<210>  21
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  21

Arg Arg Ala Arg 
1               


<210>  22
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  22

Ser Arg Ala Gly 
1               


<210>  23
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  23

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
            980                 985         


<210>  24
<211>  1642
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  24

Met Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Ala Thr Val Cys 
305                 310                 315                 320 


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
                325                 330                 335     


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
            340                 345                 350         


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
        355                 360                 365             


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    370                 375                 380                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
385                 390                 395                 400 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                405                 410                 415     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            420                 425                 430         


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
        435                 440                 445             


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
    450                 455                 460                 


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Gly 
465                 470                 475                 480 


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
                485                 490                 495     


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            500                 505                 510         


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        515                 520                 525             


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    530                 535                 540                 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
545                 550                 555                 560 


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                565                 570                 575     


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            580                 585                 590         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        595                 600                 605             


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    610                 615                 620                 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
625                 630                 635                 640 


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                645                 650                 655     


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            660                 665                 670         


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        675                 680                 685             


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    690                 695                 700                 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
705                 710                 715                 720 


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                725                 730                 735     


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            740                 745                 750         


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        755                 760                 765             


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
    770                 775                 780                 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
785                 790                 795                 800 


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                805                 810                 815     


Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            820                 825                 830         


Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        835                 840                 845             


Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    850                 855                 860                 


Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
865                 870                 875                 880 


Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                885                 890                 895     


Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            900                 905                 910         


Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        915                 920                 925             


Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    930                 935                 940                 


Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
945                 950                 955                 960 


Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                965                 970                 975     


Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            980                 985                 990         


Ile Asp Leu Gln Glu Leu Gly Lys  Tyr Glu Gln Ser Asp  Asn Gly Pro 
        995                 1000                 1005             


Gln Asn  Gln Arg Asn Ala Pro  Arg Ile Thr Phe Gly  Gly Pro Ser 
    1010                 1015                 1020             


Asp Ser  Thr Gly Ser Asn Gln  Asn Gly Glu Arg Ser  Gly Ala Arg 
    1025                 1030                 1035             


Ser Lys  Gln Arg Arg Pro Gln  Gly Leu Pro Asn Asn  Thr Ala Ser 
    1040                 1045                 1050             


Trp Phe  Thr Ala Leu Thr Gln  His Gly Lys Glu Asp  Leu Lys Phe 
    1055                 1060                 1065             


Pro Arg  Gly Gln Gly Val Pro  Ile Asn Thr Asn Ser  Ser Pro Asp 
    1070                 1075                 1080             


Asp Gln  Ile Gly Tyr Tyr Arg  Arg Ala Thr Arg Arg  Ile Arg Gly 
    1085                 1090                 1095             


Gly Asp  Gly Lys Met Lys Asp  Leu Ser Pro Arg Trp  Tyr Phe Tyr 
    1100                 1105                 1110             


Tyr Leu  Gly Thr Gly Pro Glu  Ala Gly Leu Pro Tyr  Gly Ala Asn 
    1115                 1120                 1125             


Lys Asp  Gly Ile Ile Trp Val  Ala Thr Glu Gly Ala  Leu Asn Thr 
    1130                 1135                 1140             


Pro Lys  Asp His Ile Gly Thr  Arg Asn Pro Ala Asn  Asn Ala Ala 
    1145                 1150                 1155             


Ile Val  Leu Gln Leu Pro Gln  Gly Thr Thr Leu Pro  Lys Gly Phe 
    1160                 1165                 1170             


Tyr Ala  Glu Gly Ser Arg Gly  Gly Ser Gln Ala Ser  Ser Arg Ser 
    1175                 1180                 1185             


Ser Ser  Arg Ser Arg Asn Ser  Ser Arg Asn Ser Thr  Pro Gly Ser 
    1190                 1195                 1200             


Ser Arg  Gly Thr Ser Pro Ala  Arg Met Ala Gly Asn  Gly Gly Asp 
    1205                 1210                 1215             


Ala Ala  Leu Ala Leu Leu Leu  Leu Asp Arg Leu Asn  Gln Leu Glu 
    1220                 1225                 1230             


Ser Lys  Met Ser Gly Lys Gly  Gln Gln Gln Gln Gly  Gln Thr Val 
    1235                 1240                 1245             


Thr Lys  Lys Ser Ala Ala Glu  Ala Ser Lys Lys Pro  Arg Gln Lys 
    1250                 1255                 1260             


Arg Thr  Ala Thr Lys Ala Tyr  Asn Val Thr Gln Ala  Phe Gly Arg 
    1265                 1270                 1275             


Arg Gly  Pro Glu Gln Thr Gln  Gly Asn Phe Gly Asp  Gln Glu Leu 
    1280                 1285                 1290             


Ile Arg  Gln Gly Thr Asp Tyr  Lys His Trp Pro Gln  Ile Ala Gln 
    1295                 1300                 1305             


Phe Ala  Pro Ser Ala Ser Ala  Phe Phe Gly Met Ser  Arg Ile Gly 
    1310                 1315                 1320             


Met Glu  Val Thr Pro Ser Gly  Thr Trp Leu Thr Tyr  Thr Gly Ala 
    1325                 1330                 1335             


Ile Lys  Leu Asp Asp Lys Asp  Pro Asn Phe Lys Asp  Gln Val Ile 
    1340                 1345                 1350             


Leu Leu  Asn Lys His Ile Asp  Ala Tyr Lys Thr Phe  Pro Pro Thr 
    1355                 1360                 1365             


Glu Pro  Lys Lys Asp Lys Lys  Lys Lys Ala Asp Glu  Thr Gln Ala 
    1370                 1375                 1380             


Leu Pro  Gln Arg Gln Lys Lys  Gln Gln Thr Val Thr  Leu Leu Pro 
    1385                 1390                 1395             


Ala Ala  Asp Leu Asp Asp Phe  Ser Lys Gln Leu Gln  Gln Ser Met 
    1400                 1405                 1410             


Ser Ser  Ala Asp Ser Thr Gln  Ala Ala Asp Ser Asn  Gly Thr Ile 
    1415                 1420                 1425             


Thr Val  Glu Glu Leu Lys Lys  Leu Leu Glu Gln Trp  Asn Leu Val 
    1430                 1435                 1440             


Ile Gly  Phe Leu Phe Leu Thr  Trp Ile Cys Leu Leu  Gln Phe Ala 
    1445                 1450                 1455             


Tyr Ala  Asn Arg Asn Arg Phe  Leu Tyr Ile Ile Lys  Leu Ile Phe 
    1460                 1465                 1470             


Leu Trp  Leu Leu Trp Pro Val  Thr Leu Ala Cys Phe  Val Leu Ala 
    1475                 1480                 1485             


Ala Val  Tyr Arg Ile Asn Trp  Ile Thr Gly Gly Ile  Ala Ile Ala 
    1490                 1495                 1500             


Met Ala  Cys Leu Val Gly Leu  Met Trp Leu Ser Tyr  Phe Ile Ala 
    1505                 1510                 1515             


Ser Phe  Arg Leu Phe Ala Arg  Thr Arg Ser Met Trp  Ser Phe Asn 
    1520                 1525                 1530             


Pro Glu  Thr Asn Ile Leu Leu  Asn Val Pro Leu His  Gly Thr Ile 
    1535                 1540                 1545             


Leu Thr  Arg Pro Leu Leu Glu  Ser Glu Leu Val Ile  Gly Ala Val 
    1550                 1555                 1560             


Ile Leu  Arg Gly His Leu Arg  Ile Ala Gly His His  Leu Gly Arg 
    1565                 1570                 1575             


Cys Asp  Ile Lys Asp Leu Pro  Lys Glu Ile Thr Val  Ala Thr Ser 
    1580                 1585                 1590             


Arg Thr  Leu Ser Tyr Tyr Lys  Leu Gly Ala Ser Gln  Arg Val Ala 
    1595                 1600                 1605             


Gly Asp  Ser Gly Phe Ala Ala  Tyr Ser Arg Tyr Arg  Ile Gly Asn 
    1610                 1615                 1620             


Tyr Lys  Leu Asn Thr Asp His  Ser Ser Ser Ser Asp  Asn Ile Ala 
    1625                 1630                 1635             


Leu Leu  Val Gln 
    1640         


<210>  25
<211>  1593
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  25

Met Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr 
1               5                   10                  15      


Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser 
            20                  25                  30          


Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn 
        35                  40                  45              


Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys 
    50                  55                  60                  


Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala 
65                  70                  75                  80  


Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr 
                85                  90                  95      


Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn 
            100                 105                 110         


Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu 
        115                 120                 125             


Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe 
    130                 135                 140                 


Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln 
145                 150                 155                 160 


Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu 
                165                 170                 175     


Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser 
            180                 185                 190         


Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser 
        195                 200                 205             


Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg 
    210                 215                 220                 


Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp 
225                 230                 235                 240 


Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr 
                245                 250                 255     


Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile 
            260                 265                 270         


Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys 
        275                 280                 285             


Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
    290                 295                 300                 


Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Ala Thr Val Cys 
305                 310                 315                 320 


Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
                325                 330                 335     


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
            340                 345                 350         


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
        355                 360                 365             


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    370                 375                 380                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
385                 390                 395                 400 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                405                 410                 415     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            420                 425                 430         


Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala 
        435                 440                 445             


Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly 
    450                 455                 460                 


Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Gly 
465                 470                 475                 480 


Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala 
                485                 490                 495     


Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn 
            500                 505                 510         


Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys 
        515                 520                 525             


Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys 
    530                 535                 540                 


Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg 
545                 550                 555                 560 


Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val 
                565                 570                 575     


Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe 
            580                 585                 590         


Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser 
        595                 600                 605             


Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala 
    610                 615                 620                 


Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala 
625                 630                 635                 640 


Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu 
                645                 650                 655     


Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu 
            660                 665                 670         


Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala 
        675                 680                 685             


Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile 
    690                 695                 700                 


Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn 
705                 710                 715                 720 


Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr 
                725                 730                 735     


Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln 
            740                 745                 750         


Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile 
        755                 760                 765             


Ser Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala 
    770                 775                 780                 


Glu Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln 
785                 790                 795                 800 


Thr Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser 
                805                 810                 815     


Ala Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser 
            820                 825                 830         


Lys Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro 
        835                 840                 845             


Gln Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro 
    850                 855                 860                 


Ala Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly 
865                 870                 875                 880 


Lys Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His 
                885                 890                 895     


Trp Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr 
            900                 905                 910         


Asp Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val 
        915                 920                 925             


Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys 
    930                 935                 940                 


Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp 
945                 950                 955                 960 


Leu Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys 
                965                 970                 975     


Glu Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu 
            980                 985                 990         


Ile Asp Leu Gln Glu Leu Gly Lys  Tyr Glu Gln Ser Asp  Asn Gly Pro 
        995                 1000                 1005             


Gln Asn  Gln Arg Asn Ala Pro  Arg Ile Thr Phe Gly  Gly Pro Ser 
    1010                 1015                 1020             


Asp Ser  Thr Gly Ser Asn Gln  Asn Gly Glu Arg Ser  Gly Ala Arg 
    1025                 1030                 1035             


Ser Lys  Gln Arg Arg Pro Gln  Gly Leu Pro Asn Asn  Thr Ala Ser 
    1040                 1045                 1050             


Trp Phe  Thr Ala Leu Thr Gln  His Gly Lys Glu Asp  Leu Lys Phe 
    1055                 1060                 1065             


Pro Arg  Gly Gln Gly Val Pro  Ile Asn Thr Asn Ser  Ser Pro Asp 
    1070                 1075                 1080             


Asp Gln  Ile Gly Tyr Tyr Arg  Arg Ala Thr Arg Arg  Ile Arg Gly 
    1085                 1090                 1095             


Gly Asp  Gly Lys Met Lys Asp  Leu Ser Pro Arg Trp  Tyr Phe Tyr 
    1100                 1105                 1110             


Tyr Leu  Gly Thr Gly Pro Glu  Ala Gly Leu Pro Tyr  Gly Ala Asn 
    1115                 1120                 1125             


Lys Asp  Gly Ile Ile Trp Val  Ala Thr Glu Gly Ala  Leu Asn Thr 
    1130                 1135                 1140             


Pro Lys  Asp His Ile Gly Thr  Arg Asn Pro Ala Asn  Asn Ala Ala 
    1145                 1150                 1155             


Ile Val  Leu Gln Leu Pro Gln  Gly Thr Thr Leu Pro  Lys Gly Phe 
    1160                 1165                 1170             


Tyr Ala  Glu Gly Ser Arg Gly  Gly Ser Gln Ala Ser  Ser Arg Ser 
    1175                 1180                 1185             


Ser Ser  Arg Ser Arg Asn Ser  Ser Arg Asn Ser Thr  Pro Gly Ser 
    1190                 1195                 1200             


Ser Arg  Gly Thr Ser Pro Ala  Arg Met Ala Gly Asn  Gly Gly Asp 
    1205                 1210                 1215             


Ala Ala  Leu Ala Leu Leu Leu  Leu Asp Arg Leu Asn  Gln Leu Glu 
    1220                 1225                 1230             


Ser Lys  Met Ser Gly Lys Gly  Gln Gln Gln Gln Gly  Gln Thr Val 
    1235                 1240                 1245             


Thr Lys  Lys Ser Ala Ala Glu  Ala Ser Lys Lys Pro  Arg Gln Lys 
    1250                 1255                 1260             


Arg Thr  Ala Thr Lys Ala Tyr  Asn Val Thr Gln Ala  Phe Gly Arg 
    1265                 1270                 1275             


Arg Gly  Pro Glu Gln Thr Gln  Gly Asn Phe Gly Asp  Gln Glu Leu 
    1280                 1285                 1290             


Ile Arg  Gln Gly Thr Asp Tyr  Lys His Trp Pro Gln  Ile Ala Gln 
    1295                 1300                 1305             


Phe Ala  Pro Ser Ala Ser Ala  Phe Phe Gly Met Ser  Arg Ile Gly 
    1310                 1315                 1320             


Met Glu  Val Thr Pro Ser Gly  Thr Trp Leu Thr Tyr  Thr Gly Ala 
    1325                 1330                 1335             


Ile Lys  Leu Asp Asp Lys Asp  Pro Asn Phe Lys Asp  Gln Val Ile 
    1340                 1345                 1350             


Leu Leu  Asn Lys His Ile Asp  Ala Tyr Lys Thr Phe  Pro Pro Thr 
    1355                 1360                 1365             


Glu Pro  Lys Lys Asp Lys Lys  Lys Lys Ala Asp Glu  Thr Gln Ala 
    1370                 1375                 1380             


Leu Pro  Gln Arg Gln Lys Lys  Gln Gln Thr Val Thr  Leu Leu Pro 
    1385                 1390                 1395             


Ala Ala  Asp Leu Asp Asp Phe  Ser Lys Gln Leu Gln  Gln Ser Met 
    1400                 1405                 1410             


Ser Ser  Ala Asp Ser Thr Gln  Ala Ala Asp Ser Asn  Gly Thr Ile 
    1415                 1420                 1425             


Thr Val  Glu Glu Leu Lys Lys  Leu Leu Glu Gln Asn  Arg Asn Arg 
    1430                 1435                 1440             


Phe Leu  Tyr Ile Ile Lys Leu  Thr Leu Ala Cys Phe  Val Leu Ala 
    1445                 1450                 1455             


Ala Val  Asn Trp Ile Thr Gly  Gly Leu Met Trp Leu  Ser Tyr Phe 
    1460                 1465                 1470             


Ile Ala  Arg Thr Arg Ser Met  Trp Ser Phe Asn Pro  Glu Thr Asn 
    1475                 1480                 1485             


Ile Leu  Leu Asn Val Pro Leu  His Gly Thr Ile Leu  Thr Arg Pro 
    1490                 1495                 1500             


Leu Leu  Glu Ser Glu Leu Val  Ile Gly Ala Val Ile  Leu Arg Gly 
    1505                 1510                 1515             


His Leu  Arg Ile Ala Gly His  His Leu Gly Arg Cys  Asp Ile Lys 
    1520                 1525                 1530             


Asp Leu  Pro Lys Glu Ile Thr  Val Ala Thr Ser Arg  Thr Leu Ser 
    1535                 1540                 1545             


Tyr Tyr  Lys Leu Gly Ala Ser  Gln Arg Val Ala Gly  Asp Ser Gly 
    1550                 1555                 1560             


Phe Ala  Ala Tyr Ser Arg Tyr  Arg Ile Gly Asn Tyr  Lys Leu Asn 
    1565                 1570                 1575             


Thr Asp  His Ser Ser Ser Ser  Asp Asn Ile Ala Leu  Leu Val Gln 
    1580                 1585                 1590             


<210>  26
<211>  1369
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  26

Met Thr Asn Ser Arg Ile Lys Ala Ser Met Pro Thr Thr Ile Ala Lys 
1               5                   10                  15      


Asn Thr Val Lys Ser Val Gly Lys Phe Cys Leu Glu Ala Ser Phe Asn 
            20                  25                  30          


Tyr Leu Lys Ser Pro Asn Phe Ser Lys Leu Ile Asn Ile Ile Ile Trp 
        35                  40                  45              


Phe Leu Leu Leu Ser Val Cys Leu Gly Ser Leu Ile Tyr Ser Thr Ala 
    50                  55                  60                  


Ala Leu Gly Val Leu Met Ser Asn Leu Gly Met Pro Ser Tyr Cys Thr 
65                  70                  75                  80  


Gly Tyr Arg Glu Gly Tyr Leu Asn Ser Thr Asn Val Thr Ile Ala Thr 
                85                  90                  95      


Tyr Cys Thr Gly Ser Ile Pro Cys Ser Val Cys Leu Ser Gly Leu Asp 
            100                 105                 110         


Ser Leu Asp Thr Tyr Pro Ser Leu Glu Thr Ile Gln Ile Thr Ile Ser 
        115                 120                 125             


Ser Phe Lys Trp Asp Leu Thr Ala Phe Gly Leu Val Ala Glu Trp Phe 
    130                 135                 140                 


Leu Ala Tyr Ile Leu Phe Thr Arg Phe Phe Tyr Val Leu Gly Leu Ala 
145                 150                 155                 160 


Ala Ile Met Gln Leu Phe Phe Ser Tyr Phe Ala Val His Phe Ile Ser 
                165                 170                 175     


Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Val Gln Met Ala Pro 
            180                 185                 190         


Ile Ser Ala Met Val Arg Met Tyr Ile Phe Phe Ala Ser Phe Tyr Tyr 
        195                 200                 205             


Val Trp Lys Ser Tyr Val His Val Val Asp Gly Cys Asn Ser Ser Thr 
    210                 215                 220                 


Cys Met Met Cys Tyr Lys Arg Asn Arg Ala Thr Arg Val Glu Cys Thr 
225                 230                 235                 240 


Thr Ile Val Asn Gly Val Arg Arg Ser Phe Tyr Val Tyr Ala Asn Gly 
                245                 250                 255     


Gly Lys Gly Phe Cys Lys Leu His Asn Trp Asn Cys Val Asn Cys Asp 
            260                 265                 270         


Thr Phe Cys Ala Gly Ser Thr Phe Ile Ser Asp Glu Val Ala Arg Asp 
        275                 280                 285             


Leu Ser Leu Gln Phe Lys Arg Pro Ile Asn Pro Thr Asp Gln Ser Ser 
    290                 295                 300                 


Tyr Ile Val Asp Ser Val Thr Val Lys Asn Gly Ser Ile His Leu Tyr 
305                 310                 315                 320 


Phe Asp Lys Ala Gly Gln Lys Thr Tyr Glu Arg His Ser Leu Ser His 
                325                 330                 335     


Phe Val Asn Leu Asp Asn Leu Arg Ala Asn Asn Thr Lys Gly Ser Leu 
            340                 345                 350         


Pro Ile Asn Val Ile Val Phe Asp Gly Lys Ser Lys Cys Glu Glu Ser 
        355                 360                 365             


Ser Ala Lys Ser Ala Ser Val Tyr Tyr Ser Gln Leu Met Cys Gln Pro 
    370                 375                 380                 


Ile Leu Leu Leu Asp Gln Ala Leu Val Ser Asp Val Gly Asp Ser Ala 
385                 390                 395                 400 


Glu Val Ala Val Lys Met Phe Asp Ala Tyr Val Asn Thr Phe Ser Ser 
                405                 410                 415     


Thr Phe Asn Val Pro Met Glu Lys Leu Lys Thr Leu Val Ala Thr Ala 
            420                 425                 430         


Glu Ala Glu Leu Ala Lys Asn Val Ser Leu Asp Asn Val Leu Ser Thr 
        435                 440                 445             


Phe Ile Ser Ala Ala Arg Gln Gly Phe Val Asp Ser Asp Val Glu Thr 
    450                 455                 460                 


Lys Asp Val Val Glu Cys Leu Lys Leu Ser His Gln Ser Asp Ile Glu 
465                 470                 475                 480 


Val Thr Gly Asp Ser Cys Asn Asn Tyr Met Leu Thr Tyr Asn Lys Val 
                485                 490                 495     


Glu Asn Met Thr Pro Arg Asp Leu Gly Ala Cys Ile Asp Cys Ser Ala 
            500                 505                 510         


Arg His Ile Asn Ala Gln Val Ala Lys Ser His Asn Ile Ala Leu Ile 
        515                 520                 525             


Trp Asn Val Lys Asp Phe Met Ser Leu Ser Glu Gln Leu Arg Lys Gln 
    530                 535                 540                 


Ile Arg Ser Ala Ala Lys Lys Asn Asn Leu Pro Phe Lys Leu Thr Cys 
545                 550                 555                 560 


Ala Thr Thr Arg Gln Val Val Asn Val Val Thr Thr Lys Ile Ala Leu 
                565                 570                 575     


Lys Gly Gly Lys Ile Val Asn Asn Trp Leu Lys Gln Leu Ile Lys Val 
            580                 585                 590         


Thr Leu Val Phe Leu Phe Val Ala Ala Ile Phe Tyr Leu Ile Thr Pro 
        595                 600                 605             


Val His Val Met Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly 
    610                 615                 620                 


Tyr Lys Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr Asp 
625                 630                 635                 640 


Thr Cys Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe Ser Gln 
                645                 650                 655     


Arg Gly Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu Ile Ala Ala 
            660                 665                 670         


Val Ile Thr Arg Glu Val Gly Phe Val Val Pro Gly Leu Pro Gly Thr 
        675                 680                 685             


Ile Leu Arg Thr Thr Asn Gly Asp Phe Leu His Phe Leu Pro Arg Val 
    690                 695                 700                 


Phe Ser Ala Val Gly Asn Ile Cys Tyr Thr Pro Ser Lys Leu Ile Glu 
705                 710                 715                 720 


Tyr Thr Asp Phe Ala Thr Ser Ala Cys Val Leu Ala Ala Glu Cys Thr 
                725                 730                 735     


Ile Phe Lys Asp Ala Ser Gly Lys Pro Val Pro Tyr Cys Tyr Asp Thr 
            740                 745                 750         


Asn Val Leu Glu Gly Ser Val Ala Tyr Glu Ser Leu Arg Pro Asp Thr 
        755                 760                 765             


Arg Tyr Val Leu Met Asp Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr 
    770                 775                 780                 


Leu Glu Gly Ser Val Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys 
785                 790                 795                 800 


Arg His Gly Thr Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr 
                805                 810                 815     


Ser Gly Arg Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly 
            820                 825                 830         


Val Phe Cys Gly Val Asp Ala Val Asn Leu Leu Thr Asn Met Phe Thr 
        835                 840                 845             


Pro Leu Ile Gln Pro Ile Gly Ala Leu Asp Ile Ser Ala Ser Ile Val 
    850                 855                 860                 


Ala Gly Gly Ile Val Ala Ile Val Val Thr Cys Leu Ala Tyr Tyr Phe 
865                 870                 875                 880 


Met Arg Phe Arg Arg Ala Phe Gly Glu Tyr Ser His Val Val Ala Phe 
                885                 890                 895     


Asn Thr Leu Leu Phe Leu Met Ser Phe Thr Val Leu Cys Leu Thr Pro 
            900                 905                 910         


Val Tyr Ser Phe Leu Pro Gly Val Tyr Ser Val Ile Tyr Leu Tyr Leu 
        915                 920                 925             


Thr Phe Tyr Leu Thr Asn Asp Val Ser Phe Leu Ala His Ile Gln Trp 
    930                 935                 940                 


Met Val Met Phe Thr Pro Leu Val Pro Phe Trp Ile Thr Ile Ala Tyr 
945                 950                 955                 960 


Ile Ile Cys Ile Ser Thr Lys His Phe Tyr Trp Phe Phe Ser Asn Tyr 
                965                 970                 975     


Leu Lys Arg Arg Val Val Phe Asn Gly Val Ser Phe Ser Thr Phe Glu 
            980                 985                 990         


Glu Ala Ala Leu Cys Thr Phe Leu  Leu Asn Lys Glu Met  Tyr Leu Lys 
        995                 1000                 1005             


Leu Arg  Ser Asp Val Leu Leu  Pro Leu Thr Gln Tyr  Asn Arg Tyr 
    1010                 1015                 1020             


Leu Ala  Leu Tyr Asn Lys Tyr  Lys Tyr Phe Ser Gly  Ala Met Asp 
    1025                 1030                 1035             


Thr Thr  Ser Tyr Arg Glu Ala  Ala Cys Cys His Leu  Ala Lys Ala 
    1040                 1045                 1050             


Leu Asn  Asp Phe Ser Asn Ser  Gly Ser Asp Val Leu  Tyr Gln Pro 
    1055                 1060                 1065             


Pro Gln  Thr Ser Ile Thr Ser  Ala Val Leu Gln Ser  Ala Val Lys 
    1070                 1075                 1080             


Arg Thr  Ile Lys Gly Thr His  His Trp Leu Leu Leu  Thr Ile Leu 
    1085                 1090                 1095             


Thr Ser  Leu Leu Val Leu Val  Gln Ser Thr Gln Trp  Ser Leu Phe 
    1100                 1105                 1110             


Phe Phe  Leu Tyr Glu Asn Ala  Phe Leu Pro Phe Ala  Met Gly Ile 
    1115                 1120                 1125             


Ile Ala  Met Ser Ala Phe Ala  Met Met Phe Val Lys  His Lys His 
    1130                 1135                 1140             


Ala Phe  Leu Cys Leu Phe Leu  Leu Pro Ser Leu Ala  Thr Val Ala 
    1145                 1150                 1155             


Tyr Phe  Asn Met Val Tyr Met  Pro Ala Ser Trp Val  Met Arg Ile 
    1160                 1165                 1170             


Met Thr  Trp Leu Asp Met Val  Asp Thr Ser Leu Ser  Gly Phe Lys 
    1175                 1180                 1185             


Leu Lys  Asp Cys Val Met Tyr  Ala Ser Ala Val Val  Leu Leu Ile 
    1190                 1195                 1200             


Leu Met  Thr Ala Arg Thr Val  Tyr Asp Asp Gly Ala  Arg Arg Val 
    1205                 1210                 1215             


Trp Thr  Leu Met Asn Val Leu  Thr Leu Val Tyr Lys  Val Tyr Tyr 
    1220                 1225                 1230             


Gly Asn  Ala Leu Asp Gln Ala  Ile Ser Met Trp Ala  Leu Ile Ile 
    1235                 1240                 1245             


Ser Val  Thr Ser Asn Tyr Ser  Gly Val Val Thr Thr  Val Met Phe 
    1250                 1255                 1260             


Leu Ala  Arg Gly Ile Val Phe  Met Cys Val Glu Tyr  Cys Pro Ile 
    1265                 1270                 1275             


Phe Phe  Ile Thr Gly Asn Thr  Leu Gln Cys Ile Met  Leu Val Tyr 
    1280                 1285                 1290             


Cys Phe  Leu Gly Tyr Phe Cys  Thr Cys Tyr Phe Gly  Leu Phe Cys 
    1295                 1300                 1305             


Leu Leu  Asn Arg Tyr Phe Arg  Leu Thr Leu Gly Val  Tyr Asp Tyr 
    1310                 1315                 1320             


Leu Val  Ser Thr Gln Glu Phe  Arg Tyr Met Asn Ser  Gln Gly Leu 
    1325                 1330                 1335             


Leu Pro  Pro Lys Asn Ser Ile  Asp Ala Phe Lys Leu  Asn Ile Lys 
    1340                 1345                 1350             


Leu Leu  Gly Val Gly Gly Lys  Pro Cys Ile Lys Val  Ala Thr Val 
    1355                 1360                 1365             


Gln 
    


<210>  27
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  27

Met Thr Asn Ser Arg Ile Lys Ala Ser Met Pro Thr Thr Ile Ala Lys 
1               5                   10                  15      


Asn Thr Val Lys Ser Val Gly Lys Phe Cys Leu Glu Ala Ser Phe Asn 
            20                  25                  30          


Tyr Leu Lys Ser Pro Asn Phe Ser Lys Leu Ile Asn Leu Met Ser Asn 
        35                  40                  45              


Leu Gly Met Pro Ser Tyr Cys Thr Gly Tyr Arg Glu Gly Tyr Leu Asn 
    50                  55                  60                  


Ser Thr Asn Val Thr Ile Ala Thr Tyr Cys Thr Gly Ser Ile Pro Cys 
65                  70                  75                  80  


Ser Val Cys Leu Ser Gly Leu Asp Ser Leu Asp Thr Tyr Pro Ser Leu 
                85                  90                  95      


Glu Thr Ile Gln Ile Thr Ile Ser Ser Phe Lys Trp Asp Leu Thr Ala 
            100                 105                 110         


Phe Gly Leu Val Ala Glu Trp Ser Tyr Phe Ala Val His Phe Ile Ser 
        115                 120                 125             


Asn Ser Trp Leu Met Trp Leu Ile Ile Asn Leu Lys Ser Tyr Val His 
    130                 135                 140                 


Val Val Asp Gly Cys Asn Ser Ser Thr Cys Met Met Cys Tyr Lys Arg 
145                 150                 155                 160 


Asn Arg Ala Thr Arg Val Glu Cys Thr Thr Ile Val Asn Gly Val Arg 
                165                 170                 175     


Arg Ser Phe Tyr Val Tyr Ala Asn Gly Gly Lys Gly Phe Cys Lys Leu 
            180                 185                 190         


His Asn Trp Asn Cys Val Asn Cys Asp Thr Phe Cys Ala Gly Ser Thr 
        195                 200                 205             


Phe Ile Ser Asp Glu Val Ala Arg Asp Leu Ser Leu Gln Phe Lys Arg 
    210                 215                 220                 


Pro Ile Asn Pro Thr Asp Gln Ser Ser Tyr Ile Val Asp Ser Val Thr 
225                 230                 235                 240 


Val Lys Asn Gly Ser Ile His Leu Tyr Phe Asp Lys Ala Gly Gln Lys 
                245                 250                 255     


Thr Tyr Glu Arg His Ser Leu Ser His Phe Val Asn Leu Asp Asn Leu 
            260                 265                 270         


Arg Ala Asn Asn Thr Lys Gly Ser Leu Pro Ile Asn Val Ile Val Phe 
        275                 280                 285             


Asp Gly Lys Ser Lys Cys Glu Glu Ser Ser Ala Lys Ser Ala Ser Val 
    290                 295                 300                 


Tyr Tyr Ser Gln Leu Met Cys Gln Pro Ile Leu Leu Leu Asp Gln Ala 
305                 310                 315                 320 


Leu Val Ser Asp Val Gly Asp Ser Ala Glu Val Ala Val Lys Met Phe 
                325                 330                 335     


Asp Ala Tyr Val Asn Thr Phe Ser Ser Thr Phe Asn Val Pro Met Glu 
            340                 345                 350         


Lys Leu Lys Thr Leu Val Ala Thr Ala Glu Ala Glu Leu Ala Lys Asn 
        355                 360                 365             


Val Ser Leu Asp Asn Val Leu Ser Thr Phe Ile Ser Ala Ala Arg Gln 
    370                 375                 380                 


Gly Phe Val Asp Ser Asp Val Glu Thr Lys Asp Val Val Glu Cys Leu 
385                 390                 395                 400 


Lys Leu Ser His Gln Ser Asp Ile Glu Val Thr Gly Asp Ser Cys Asn 
                405                 410                 415     


Asn Tyr Met Leu Thr Tyr Asn Lys Val Glu Asn Met Thr Pro Arg Asp 
            420                 425                 430         


Leu Gly Ala Cys Ile Asp Cys Ser Ala Arg His Ile Asn Ala Gln Val 
        435                 440                 445             


Ala Lys Ser His Asn Ile Ala Leu Ile Trp Asn Val Lys Asp Phe Met 
    450                 455                 460                 


Ser Leu Ser Glu Gln Leu Arg Lys Gln Ile Arg Ser Ala Ala Lys Lys 
465                 470                 475                 480 


Asn Asn Leu Pro Phe Lys Leu Thr Cys Ala Thr Thr Arg Gln Val Val 
                485                 490                 495     


Asn Val Val Thr Thr Lys Ile Ala Leu Lys Gly Gly Lys Ile Val Asn 
            500                 505                 510         


Asn Trp Ser Lys His Thr Asp Phe Ser Ser Glu Ile Ile Gly Tyr Lys 
        515                 520                 525             


Ala Ile Asp Gly Gly Val Thr Arg Asp Ile Ala Ser Thr Asp Thr Cys 
    530                 535                 540                 


Phe Ala Asn Lys His Ala Asp Phe Asp Thr Trp Phe Ser Gln Arg Gly 
545                 550                 555                 560 


Gly Ser Tyr Thr Asn Asp Lys Ala Cys Pro Leu Ile Ala Ala Val Ile 
                565                 570                 575     


Thr Arg Glu Val Gly Phe Val Val Pro Gly Leu Pro Gly Thr Ile Leu 
            580                 585                 590         


Arg Thr Thr Asn Gly Asp Phe Leu His Phe Leu Pro Arg Val Phe Ser 
        595                 600                 605             


Ala Val Gly Asn Ile Cys Tyr Thr Pro Ser Lys Leu Ile Glu Tyr Thr 
    610                 615                 620                 


Asp Phe Ala Thr Ser Ala Cys Val Leu Ala Ala Glu Cys Thr Ile Phe 
625                 630                 635                 640 


Lys Asp Ala Ser Gly Lys Pro Val Pro Tyr Cys Tyr Asp Thr Asn Val 
                645                 650                 655     


Leu Glu Gly Ser Val Ala Tyr Glu Ser Leu Arg Pro Asp Thr Arg Tyr 
            660                 665                 670         


Val Leu Met Asp Gly Ser Ile Ile Gln Phe Pro Asn Thr Tyr Leu Glu 
        675                 680                 685             


Gly Ser Val Arg Val Val Thr Thr Phe Asp Ser Glu Tyr Cys Arg His 
    690                 695                 700                 


Gly Thr Cys Glu Arg Ser Glu Ala Gly Val Cys Val Ser Thr Ser Gly 
705                 710                 715                 720 


Arg Trp Val Leu Asn Asn Asp Tyr Tyr Arg Ser Leu Pro Gly Val Phe 
                725                 730                 735     


Cys Gly Val Pro Leu Ile Gln Pro Ile Gly Ala Leu Asp Arg Phe Arg 
            740                 745                 750         


Arg Ala Phe Gly Glu Tyr Ser His Ser Phe Leu Pro Gly His Ile Gln 
        755                 760                 765             


Trp Met Val Met Phe Thr Pro Leu Trp Phe Phe Ser Asn Tyr Leu Lys 
    770                 775                 780                 


Arg Arg Val Asn Lys Glu Met Tyr Leu Lys Leu Arg Ser Asp Val Leu 
785                 790                 795                 800 


Leu Pro Leu Thr Gln Tyr Asn Arg Tyr Leu Ala Leu Tyr Asn Lys Tyr 
                805                 810                 815     


Lys Tyr Phe Ser Gly Ala Met Asp Thr Thr Ser Tyr Arg Glu Ala Ala 
            820                 825                 830         


Cys Cys His Leu Ala Lys Ala Leu Asn Asp Phe Ser Asn Ser Gly Ser 
        835                 840                 845             


Asp Val Leu Tyr Gln Pro Pro Gln Thr Ser Ile Thr Ser Ala Val Leu 
    850                 855                 860                 


Gln Ser Ala Val Lys Arg Thr Ile Lys Gly Thr His Leu Tyr Glu Asn 
865                 870                 875                 880 


Ala Lys His Lys His Ala Phe Ser Trp Val Met Arg Ile Met Thr Trp 
                885                 890                 895     


Leu Asp Met Val Asp Thr Ser Leu Ser Gly Phe Lys Leu Lys Asp Cys 
            900                 905                 910         


Asp Asp Gly Ala Arg Arg Val Trp Thr Leu Met Asn Val Leu Thr Leu 
        915                 920                 925             


Val Ala Leu Asp Gln Ala Ile Ser Met Trp Ala Leu Ile Ile Ser Val 
    930                 935                 940                 


Arg Gly Ile Val Phe Met Cys Val Glu Tyr Cys Cys Thr Cys Tyr Phe 
945                 950                 955                 960 


Gly Leu Phe Cys Leu Leu Asn Arg Tyr Phe Arg Leu Thr Leu Gly Val 
                965                 970                 975     


Tyr Asp Tyr Leu Val Ser Thr Gln Glu Phe Arg Tyr Met Asn Ser Gln 
            980                 985                 990         


Gly Leu Leu Pro Pro Lys Asn Ser  Ile Asp Ala Phe Lys  Leu Asn Ile 
        995                 1000                 1005             


Lys Leu  Leu Gly Val Gly Gly  Lys Pro Cys Ile Lys  Val Ala Thr 
    1010                 1015                 1020             


Val Gln  
    1025 


<210>  28
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  28

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Lys Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
            980                 985         


<210>  29
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  29

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Asn Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
            980                 985         


<210>  30
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  30

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Tyr Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ser Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro 
            980                 985         


<210>  31
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  31

Trp Leu Gln Gly Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile Ser 
1               5                   10                  15      


<210>  32
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  32

Gly Gly Gly Gly Gly Gly 
1               5       


<210>  33
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  33

Gly Gly Gly Gly Thr 
1               5   


<210>  34
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  34

Gly Gly Gly Pro Pro Pro 
1               5       


<210>  35
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic construct

<400>  35

Gly Gly Gly Ala Pro Pro Pro 
1               5           


