                         SEQUENCE LISTING

<110>  HOUSTON GENE THERAPEUTICS LLC
       HERMONAT, Paul L.
 
<120>  COMPOSITIONS FOR TREATMENT OF VASCULAR DISEASE

<130>  01258-0001-00PCT

<150>  US 63/013,869
<151>  2020-04-22

<150>  PCT/US2020/56962
<151>  2020-10-23

<160>  132   

<170>  PatentIn version 3.5

<210>  1
<211>  2027
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2027)
<223>  5' flanking sequence of human NOX1 gene

<400>  1
gttttccata tttaaaagta gtaaattgga taccatacat gaaaatcagc tccaggtgga       60

ttcaaaacat aaatgtaaaa tgcaaaaata taaaatttct agaagaaaat ataaaagagt      120

atcttgatat ctgggtagtg atggatttct aaaacaagac ataaaatgca taaatcataa      180

aagaaatgac tggtaatcag agtgcattaa aattaagaac ttccatttat cagaaaacac      240

tattaagaga ctgaaaagac aagccataaa cataagcaat aaaagattag tataagatta      300

taaacagaac cctaagaatc taaaagcaaa agaaaaacca atagaaagat agaccaaaaa      360

gtagaatagg ctcagaatag gctcttttaa aaagagaaaa ctcaaatggc cagcagttga      420

attaaaagat gctcaaactc attagtaatc agggaaatgc aaattaaaat cataatacga      480

tagttttcca cacttacttg aattataaaa acaaaaaagt ctggaaaata ccaagggttg      540

gtaagcatgt agaggaagta gaactctcat tcataactct ctgtagtata catttaggtg      600

gtcacttcgg aacgggtttg gaattacaca gcaaagtaga atatgtgcaa atctcaggac      660

cctggaattt tactcctggg tatatacctt agagaaactg tagcatatgt gtgacattcg      720

atcaacattg ttccatcatc atatccatca gtagtaggat gaatgaatac attaatgtat      780

attcattcat gcaatggcat attagatagc agtgtaagtg aaccgcaatt acatgtacat      840

gtatgaatct caaaaaccca atgttgaaag aagcaaacca cagaagcata catacacact      900

gccaggtttc atttacaaaa agttcaaaaa caggaaaaac taaacaatat attgcttagg      960

gatgcaatta tagttagtaa aaatataaag aaaaataaca gaatgattac cccaaatttc     1020

aggatagtga ttacatccgg tggggtagag gaggggaaga agatagatgt gatcagggag     1080

ggaaatacaa agagctttaa gatactggag aaaaatagtc tattttcttt aatctgagta     1140

gtgaacacat agatacttat tccttaaaat tattctttaa gttacatatg tatgttttat     1200

atactcttct gtgtatattt caccatttta gaaaagggaa aaaaaatcag tgcccagagc     1260

tgaacacaca actctagtaa atctatcata ctagaagaca atcatctcca ttcttttgag     1320

tgctctgcct ctgtttattt tgaaccaaag tgcactttta tacttgttaa attttctctt     1380

gctctatttg gcccttcttt tcacttgtcc ttccagccag tcaagttctc cccaaagcca     1440

tcatcatata tgtcaaccac agatcatcct ccaggggaac tggtatgcta aagtttctga     1500

gctagccagg ctgaaatcca aatggcagcc ggcagatgtg gcaacagttt gaaaagtgca     1560

ctttgaaaca gcttccttac cacacacgct tccctcccta cttctcctga agtaatctgt     1620

ttacagaccc agactaataa tcttttttat gagaaacttt agcaaatctt ttatctagga     1680

aggcaatgct tcacattagg tcatgttgat aagatgatga gagagaatat tttcatccaa     1740

gaatgttgct atttcctgaa gcagtaaaat ccccacaggt aaaacccttg tggttctcat     1800

agatagggct ggtctatcta agctgatagc acagttctgt ccagagaagg aaggcagaat     1860

aaacttattc attcccagga actcttgggg taggtgtgtg tttttcacat cttaaaggct     1920

cacagaccct gcgctggaca aatgttccat tcctgaagga cctctccaga atccggattg     1980

ctgaatcttc cctgttgcct agaagggctc caaaccacct cttgaca                   2027


<210>  2
<211>  466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(466)
<223>  Exemplary human NOX1 core promoter

<400>  2
tttgaaacag cttccttacc acacacgctt ccctccctac ttctcctgaa gtaatctgtt       60

tacagaccca gactaataat cttttttatg agaaacttta gcaaatcttt tatctaggaa      120

ggcaatgctt cacattaggt catgttgata agatgatgag agagaatatt ttcatccaag      180

aatgttgcta tttcctgaag cagtaaaatc cccacaggta aaacccttgt ggttctcata      240

gatagggctg gtctatctaa gctgatagca cagttctgtc cagagaagga aggcagaata      300

aacttattca ttcccaggaa ctcttggggt aggtgtgtgt ttttcacatc ttaaaggctc      360

acagaccctg cgctggacaa atgttccatt cctgaaggac ctctccagaa tccggattgc      420

tgaatcttcc ctgttgccta gaagggctcc aaaccacctc ttgaca                     466


<210>  3
<211>  483
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Exemplary variant human NOX1 core promoter

<400>  3
tttgaaacag cttccttacc acacacgctt ccctccctac ttctcctgaa gtaatctgtt       60

tacagaccca gactaataat cttttttatg agaaacttta gcaaatcttt tatctaggaa      120

ggccaatgct tcacattagg tcatgttgat aagatgatga gagagaatat tttcatccaa      180

gaatgttgct atttcctgaa gcagtaaaat ccccacaggt aaaacccttg tggttctcat      240

agatagggct ggtctatcta agctgatagc acagttctgt ccagagaagg aaggcagaat      300

aaacttattc attcccagga actcttgggg taggtgtgtg tttttcacat cttaaaggct      360

cacagaccct gcgctggaca aattgttcca ttcctgaagg acctctccag aatccggatt      420

gctgaatctt ccctgttgcc tagaagggct ccaaaccacc tcttgacatg aacgcgtgcc      480

acc                                                                    483


<210>  4
<211>  586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant NOX1 core promoter with three NF-kB 
       binding sequences and two Oct1 binding sequences at the 5' end, 
       eNOX1 promoter

<400>  4
gaggagggga ttcccaagat cgaggagggg attcccaaga tcgaggaggg gattcccaag       60

atcaaaagta tgcaaatccc tgaaaaagta tgcaaatccc tgatttgaaa cagcttcctt      120

accacacacg cttccctccc tacttctcct gaagtaatct gtttacagac ccagactaat      180

aatctttttt atgagaaact ttagcaaatc ttttatctag gaaggccaat gcttcacatt      240

aggtcatgtt gataagatga tgagagagaa tattttcatc caagaatgtt gctatttcct      300

gaagcagtaa aatccccaca ggtaaaaccc ttgtggttct catagatagg gctggtctat      360

ctaagctgat agcacagttc tgtccagaga aggaaggcag aataaactta ttcattccca      420

ggaactcttg gggtaggtgt gtgtttttca catcttaaag gctcacagac cctgcgctgg      480

acaaattgtt ccattcctga aggacctctc cagaatccgg attgctgaat cttccctgtt      540

gcctagaagg gctccaaacc acctcttgac atgaacgcgt gccacc                     586


<210>  5
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  y is a pyrimidine

<400>  5
gggrnyyycc                                                              10


<210>  6
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  y is a pyrimidine

<400>  6
ggrrnnyycc                                                              10


<210>  7
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is as purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  h is an adenine, a cytosine, or a thymine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  y is a pyrimidine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  b is a guanine, thymine, or cytosine

<400>  7
rggrnnhhyy b                                                            11


<210>  8
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  y is a pyrimidine

<400>  8
ggggatyccc                                                              10


<210>  9
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is any nucleotide

<400>  9
gggrntttcc                                                              10


<210>  10
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  w is an adenine or a thymine

<400>  10
nggnnwttcc                                                              10


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  y is a pyrimidine

<400>  11
gggrnnyycc                                                              10


<210>  12
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  12
ggggaatccc c                                                            11


<210>  13
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  13
ggggactttc c                                                            11


<210>  14
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  14
agggggatct g                                                            11


<210>  15
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  15
agggaagtta                                                              10


<210>  16
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  16
ctggggattt a                                                            11


<210>  17
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  17
gggaattccc                                                              10


<210>  18
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of  an NF-kB binding site

<400>  18
gggaatttcc                                                              10


<210>  19
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  19
ggggattccc                                                              10


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  20
gaggagggga ttcccaagat c                                                 21


<210>  21
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  21
atgcaaat                                                                 8


<210>  22
<211>  1433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: eNOXpr-3xFLAG-mCherry

<400>  22
gaggagggga ttcccaagat cgaggagggg attcccaaga tcgaggaggg gattcccaag       60

atcaaaagta tgcaaatccc tgaaaaagta tgcaaatccc tgatttgaaa cagcttcctt      120

accacacacg cttccctccc tacttctcct gaagtaatct gtttacagac ccagactaat      180

aatctttttt atgagaaact ttagcaaatc ttttatctag gaaggccaat gcttcacatt      240

aggtcatgtt gataagatga tgagagagaa tattttcatc caagaatgtt gctatttcct      300

gaagcagtaa aatccccaca ggtaaaaccc ttgtggttct catagatagg gctggtctat      360

ctaagctgat agcacagttc tgtccagaga aggaaggcag aataaactta ttcattccca      420

ggaactcttg gggtaggtgt gtgtttttca catcttaaag gctcacagac cctgcgctgg      480

acaaattgtt ccattcctga aggacctctc cagaatccgg attgctgaat cttccctgtt      540

gcctagaagg gctccaaacc acctcttgac atgaacgcgt gccaccatgt ctgactataa      600

agaccatgat ggggactaca aagaccatga tatagattac aaagacgatg atgacaaaat      660

ggttagcaag ggggaggaag acaatatggc cataattaaa gaattcatgc gcttcaaagt      720

tcacatggaa ggaagcgtga acggacatga gttcgagata gaaggcgagg gcgaggggcg      780

gccctatgag ggaacgcaga ctgctaaact gaaggttact aaaggtggcc ctcttccttt      840

cgcatgggac atcctgtctc cgcagttcat gtatggatcc aaggcatatg ttaagcatcc      900

ggctgatata ccagattacc tcaaattgag ctttcctgaa gggtttaagt gggaaagggt      960

catgaacttt gaagacggtg gagttgtgac agttacacag gattcatcac ttcaggacgg     1020

tgagtttata tacaaggtta aacttagggg aactaatttt ccttccgacg gccccgtcat     1080

gcagaaaaaa accatggggt gggaggcgag ctccgagcgg atgtacccag aggatggagc     1140

actgaagggc gaaataaaac agcgactgaa attgaaagac ggaggtcact atgatgcaga     1200

agttaagacg acatacaagg ccaaaaagcc agttcagttg ccgggtgcat ataacgtcaa     1260

tatcaagctg gacattacat cccacaatga ggattatacg atagtggagc agtatgagcg     1320

ggcagaaggg cggcactcca caggaggaat ggacgaactc tataaatgac ccaccagcct     1380

tgtcctaata aaattaagtt gcatcatttt gtttgactac tcgagcccct gca            1433


<210>  23
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3xFLAG-mCherry amino acid sequence

<400>  23

Met Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys Met Val Ser Lys Gly Glu Glu Asp 
            20                  25                  30          


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
        35                  40                  45              


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
    50                  55                  60                  


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
                85                  90                  95      


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
            100                 105                 110         


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
        115                 120                 125             


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
    130                 135                 140                 


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
145                 150                 155                 160 


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
                165                 170                 175     


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
            180                 185                 190         


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
        195                 200                 205             


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
    210                 215                 220                 


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
225                 230                 235                 240 


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
                245                 250                 255     


Glu Leu Tyr Lys 
            260 


<210>  24
<211>  431
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(431)
<223>  Exemplary wildtype human FoxP3 amino acid sequence

<400>  24

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  25
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Exemplary human FOXP3 zinc finger and leucine zipper region

<400>  25

Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser 
1               5                   10                  15      


Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln 
            20                  25                  30          


Ala His Leu Ala Gly Lys 
        35              


<210>  26
<211>  489
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(489)
<223>  Exemplary wildtype human FoxP1 sequence

<400>  26

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Leu Gln Gln Leu Trp Lys Glu Val Thr 
        35                  40                  45              


Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu 
    50                  55                  60                  


Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser 
65                  70                  75                  80  


Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His 
                85                  90                  95      


Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser His 
            100                 105                 110         


Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val 
        115                 120                 125             


Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala 
    130                 135                 140                 


Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val 
145                 150                 155                 160 


Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala 
                165                 170                 175     


Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro 
            180                 185                 190         


Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser 
        195                 200                 205             


Glu Ala Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala 
    210                 215                 220                 


Pro Leu Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser 
225                 230                 235                 240 


Met His Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn 
                245                 250                 255     


Val Pro Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys 
            260                 265                 270         


Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln 
        275                 280                 285             


Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr 
    290                 295                 300                 


Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr 
305                 310                 315                 320 


Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val 
                325                 330                 335     


Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu 
            340                 345                 350         


Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile 
        355                 360                 365             


Lys Asn Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala 
    370                 375                 380                 


Leu Gln Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala 
385                 390                 395                 400 


Ser Met Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu 
                405                 410                 415     


Glu Leu Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser 
            420                 425                 430         


Ser Pro Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val Lys 
        435                 440                 445             


Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val 
    450                 455                 460                 


Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu 
465                 470                 475                 480 


Asp Glu Pro Val Asn Glu Asp Met Glu 
                485                 


<210>  27
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Exemplary human FOXP1 zinc finger and leucine zipper region

<400>  27

Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln 
1               5                   10                  15      


Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met 
            20                  25                  30          


Thr His Leu His Val Lys 
        35              


<210>  28
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary FOXP3(P1) amino acid sequence FOXP1 zinc 
       finger and leucine zipper region underlined

<400>  28

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln 
225                 230                 235                 240 


Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met 
                245                 250                 255     


Met Thr His Leu His Val Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  29
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary FoxP3(P1) nucleotide sequence  FoxP1 zinc 
       finger and leucine zipper region underlined

<400>  29
atgccgaatc cccggccagg caagcccagt gccccgtcac ttgcccttgg gcctagtcct       60

ggggcttcac catcctggcg agctgcacct aaggcatctg acctcttggg ggcacgagga      120

ccgggcggga cgtttcaggg aagggacctt agaggcggag ctcatgcaag ctcttcttca      180

ctgaacccga tgccgccgag tcagttgcaa ctccccacac tcccactcgt aatggtggcg      240

ccctctggcg caagactcgg acctctccca cacctgcaag ccctcttgca ggacagacca      300

cacttcatgc accaactttc aacggttgac gcacacgcac ggacaccagt gctgcaagtt      360

catccacttg aatcccctgc catgatcagc ctgacaccgc ctactaccgc gacaggtgtc      420

ttttctttga aagcgaggcc tggattgcca cctggcatca atgtggcgtc cctggagtgg      480

gtttcccgcg aacctgctct cctgtgcaca tttccaaacc cgagtgcgcc gcgaaaagat      540

agtacgttgt ccgcagtacc tcagagctca tatccacttt tggcaaacgg tgtgtgtaaa      600

tggcctggat gcgaaaaagt attcgaagag ccggaggact ttttgaaaca ttgccaagct      660

gaccacctgc tcgatgatcg gtcaaccgcg caatgcaggg tgcaaatgca agttgtacaa      720

cagctcgaat tgcagttggc gaaggacaag gagaggctgc aagcaatgat gacccatctt      780

catgttaaaa tggccctgac caaggcaagc tctgttgcaa gctccgacaa aggctcttgc      840

tgtatcgtag cggcgggatc tcaaggaccg gtcgtcccag cgtggagtgg ccctcgggaa      900

gcccctgata gtcttttcgc cgtgagacgc cacctgtggg gcagccatgg aaactccact      960

tttcctgaat ttttgcacaa tatggactac tttaagttcc ataacatgcg ccccccgttt     1020

acatacgcga cgctcatccg gtgggcaatc ttggaagcgc ctgaaaaaca acgaaccttg     1080

aacgagatat atcattggtt cacgcgaatg ttcgctttct tcagaaatca cccggctact     1140

tggaagaatg ccataagaca caatctttct ctccataaat gctttgtaag ggtcgagtcc     1200

gaaaaagggg cagtatggac tgttgacgag ctggagtttc ggaaaaagcg gtcacaacgc     1260

ccgtcaagat gctcaaaccc taccccaggc ccttga                               1296


<210>  30
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary mini-promoter TATA box nucleotide sequence

<400>  30
ttagataaag gctgtctccg cgcctatata aaactcttgt ttttcttttt tctctatcag       60

ttcatttgta gcatcttaat ttactatcct tctactatca gttgccgccg ccgtcgacgc      120

cacc                                                                   124


<210>  31
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(178)
<223>  Exemplary human IL10 amino acid sequence

<400>  31

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  32
<211>  537
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(537)
<223>  Exemplary human IL10 nucleotide sequence

<400>  32
atgcactctt ctgcacttct gtgctgcctc gtgctcctga caggtgtcag ggcgagtccc       60

ggtcagggta cgcaatctga aaactcctgc acccactttc cggggaattt gcccaacatg      120

ctgagggatc tgagagacgc tttcagccgc gttaagacat tcttccagat gaaagatcag      180

ctcgataatc ttctgttgaa agagtcactg cttgaggatt ttaaagggta tttggggtgc      240

caggctctgt cagaaatgat acagttctat ctcgaagagg tgatgcctca agcggagaac      300

caagatccag acataaaggc tcacgttaat tccttgggcg agaatctgaa aaccctgagg      360

cttaggctga gacgctgtca tcgcttcttg ccctgtgaaa acaaatccaa agcggtagag      420

caggtcaaaa atgcctttaa taagctgcaa gagaagggga tatataaggc aatgtctgag      480

tttgatatct ttataaacta tatagaagct tacatgacaa tgaaaattcg gaattag         537


<210>  33
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary 5' sequence including polyadenylation, (poly
       A) sequence

<400>  33
ttaattgagg ggccgggctc gagtgcctaa taaaaaacat ttattttcat tgccccctgc       60

agaagcttta aaccggttat cgataatcaa cctc                                   94


<210>  34
<211>  2675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary eNOX1pr-FoxP3(P1)-IL10 nucleotide sequence

<400>  34
ggggttcctg cggccgcacg cgtctgcagc ccatgcatga ggaggggatt cccaagatcg       60

aggaggggat tcccaagatc gaggagggga ttcccaagat caaaagtatg caaatccctg      120

aaaaagtatg caaatccctg atttgaaaca gcttccttac cacacacgct tccctcccta      180

cttctcctga agtaatctgt ttacagaccc agactaataa tcttttttat gagaaacttt      240

agcaaatctt ttatctagga aggccaatgc ttcacattag gtcatgttga taagatgatg      300

agagagaata ttttcatcca agaatgttgc tatttcctga agcagtaaaa tccccacagg      360

taaaaccctt gtggttctca tagatagggc tggtctatct aagctgatag cacagttctg      420

tccagagaag gaaggcagaa taaacttatt cattcccagg aactcttggg gtaggtgtgt      480

gtttttcaca tcttaaaggc tcacagaccc tgcgctggac aaattgttcc attcctgaag      540

gacctctcca gaatccggat tgctgaatct tccctgttgc ctagaagggc tccaaaccac      600

ctcttgacat gaacgcgtgc caccatgccg aatccccggc caggcaagcc cagtgccccg      660

tcacttgccc ttgggcctag tcctggggct tcaccatcct ggcgagctgc acctaaggca      720

tctgacctct tgggggcacg aggaccgggc gggacgtttc agggaaggga ccttagaggc      780

ggagctcatg caagctcttc ttcactgaac ccgatgccgc cgagtcagtt gcaactcccc      840

acactcccac tcgtaatggt ggcgccctct ggcgcaagac tcggacctct cccacacctg      900

caagccctct tgcaggacag accacacttc atgcaccaac tttcaacggt tgacgcacac      960

gcacggacac cagtgctgca agttcatcca cttgaatccc ctgccatgat cagcctgaca     1020

ccgcctacta ccgcgacagg tgtcttttct ttgaaagcga ggcctggatt gccacctggc     1080

atcaatgtgg cgtccctgga gtgggtttcc cgcgaacctg ctctcctgtg cacatttcca     1140

aacccgagtg cgccgcgaaa agatagtacg ttgtccgcag tacctcagag ctcatatcca     1200

cttttggcaa acggtgtgtg taaatggcct ggatgcgaaa aagtattcga agagccggag     1260

gactttttga aacattgcca agctgaccac ctgctcgatg atcggtcaac cgcgcaatgc     1320

agggtgcaaa tgcaagttgt acaacagctc gaattgcagt tggcgaagga caaggagagg     1380

ctgcaagcaa tgatgaccca tcttcatgtt aaaatggccc tgaccaaggc aagctctgtt     1440

gcaagctccg acaaaggctc ttgctgtatc gtagcggcgg gatctcaagg accggtcgtc     1500

ccagcgtgga gtggccctcg ggaagcccct gatagtcttt tcgccgtgag acgccacctg     1560

tggggcagcc atggaaactc cacttttcct gaatttttgc acaatatgga ctactttaag     1620

ttccataaca tgcgcccccc gtttacatac gcgacgctca tccggtgggc aatcttggaa     1680

gcgcctgaaa aacaacgaac cttgaacgag atatatcatt ggttcacgcg aatgttcgct     1740

ttcttcagaa atcacccggc tacttggaag aatgccataa gacacaatct ttctctccat     1800

aaatgctttg taagggtcga gtccgaaaaa ggggcagtat ggactgttga cgagctggag     1860

tttcggaaaa agcggtcaca acgcccgtca agatgctcaa accctacccc aggcccttga     1920

ttagataaag gctgtctccg cgcctatata aaactcttgt ttttcttttt tctctatcag     1980

ttcatttgta gcatcttaat ttactatcct tctactatca gttgccgccg ccgtcgacgc     2040

caccatgcac tcttctgcac ttctgtgctg cctcgtgctc ctgacaggtg tcagggcgag     2100

tcccggtcag ggtacgcaat ctgaaaactc ctgcacccac tttccgggga atttgcccaa     2160

catgctgagg gatctgagag acgctttcag ccgcgttaag acattcttcc agatgaaaga     2220

tcagctcgat aatcttctgt tgaaagagtc actgcttgag gattttaaag ggtatttggg     2280

gtgccaggct ctgtcagaaa tgatacagtt ctatctcgaa gaggtgatgc ctcaagcgga     2340

gaaccaagat ccagacataa aggctcacgt taattccttg ggcgagaatc tgaaaaccct     2400

gaggcttagg ctgagacgct gtcatcgctt cttgccctgt gaaaacaaat ccaaagcggt     2460

agagcaggtc aaaaatgcct ttaataagct gcaagagaag gggatatata aggcaatgtc     2520

tgagtttgat atctttataa actatataga agcttacatg acaatgaaaa ttcggaatta     2580

gttaattgag gggccgggct cgagtgccta ataaaaaaca tttattttca ttgccccctg     2640

cagaagcttt aaaccggtta tcgataatca acctc                                2675


<210>  35
<211>  715
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(715)
<223>  Exemplary wildtype human FoxP2 sequence

<400>  35

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu 
        35                  40                  45              


Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu Gln Met 
    210                 215                 220                 


Gln Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly 
225                 230                 235                 240 


Leu Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu 
                245                 250                 255     


Pro Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu 
            260                 265                 270         


Val Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly 
        275                 280                 285             


Leu Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr 
    290                 295                 300                 


Ser Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln 
305                 310                 315                 320 


Ser Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr 
                325                 330                 335     


Gly Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly 
            340                 345                 350         


Cys Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn 
        355                 360                 365             


Asn Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln 
    370                 375                 380                 


Met Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu 
385                 390                 395                 400 


Arg Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro 
                405                 410                 415     


Lys Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser 
            420                 425                 430         


Lys Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr 
        435                 440                 445             


Thr Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile 
    450                 455                 460                 


Thr Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser 
465                 470                 475                 480 


Asp Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu 
                485                 490                 495     


Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu 
            500                 505                 510         


Ile Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn 
        515                 520                 525             


Glu Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn 
    530                 535                 540                 


Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys 
545                 550                 555                 560 


Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp 
                565                 570                 575     


Glu Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro 
            580                 585                 590         


Thr Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu 
        595                 600                 605             


Asn Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu 
    610                 615                 620                 


Ser Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala 
625                 630                 635                 640 


Val His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly 
                645                 650                 655     


Asn Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His 
            660                 665                 670         


Val Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser 
        675                 680                 685             


Leu Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu 
    690                 695                 700                 


Ile Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 715 


<210>  36
<211>  678
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(678)
<223>  Exemplary wildtype human FoxP4 sequence

<400>  36

Met Met Val Glu Ser Ala Ser Glu Thr Ile Arg Ser Ala Pro Ser Gly 
1               5                   10                  15      


Gln Asn Gly Val Gly Ser Leu Ser Gly Gln Ala Asp Gly Ser Ser Gly 
            20                  25                  30          


Gly Ala Thr Gly Thr Thr Ala Ser Gly Thr Gly Arg Glu Val Thr Thr 
        35                  40                  45              


Gly Ala Asp Ser Asn Gly Glu Met Ser Pro Ala Glu Leu Leu His Phe 
    50                  55                  60                  


Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln Phe Leu Leu Gln Gln 
65                  70                  75                  80  


Ala Ser Gly Leu Ser Ser Pro Gly Asn Asn Asp Ser Lys Gln Ser Ala 
                85                  90                  95      


Ser Ala Val Gln Val Pro Val Ser Val Ala Met Met Ser Pro Gln Met 
            100                 105                 110         


Leu Thr Pro Gln Gln Met Gln Gln Ile Leu Ser Pro Pro Gln Leu Gln 
        115                 120                 125             


Ala Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Glu Tyr Tyr 
    130                 135                 140                 


Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu Thr Gln Gln Gln 
145                 150                 155                 160 


Ala Gly Lys Pro Gln Pro Lys Glu Ala Leu Gly Asn Lys Gln Leu Ala 
                165                 170                 175     


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
            180                 185                 190         


Leu Asn Leu Gln Arg Gln Gly Leu Val Ser Leu Gln Pro Asn Gln Ala 
        195                 200                 205             


Ser Gly Pro Leu Gln Thr Leu Pro Gln Ala Ala Val Cys Pro Thr Asp 
    210                 215                 220                 


Leu Pro Gln Leu Trp Lys Gly Glu Gly Ala Pro Gly Gln Pro Ala Glu 
225                 230                 235                 240 


Asp Ser Val Lys Gln Glu Gly Leu Asp Leu Thr Gly Thr Ala Ala Thr 
                245                 250                 255     


Ala Thr Ser Phe Ala Ala Pro Pro Lys Val Ser Pro Pro Leu Ser His 
            260                 265                 270         


His Thr Leu Pro Asn Gly Gln Pro Thr Val Leu Thr Ser Arg Arg Asp 
        275                 280                 285             


Ser Ser Ser His Glu Glu Thr Pro Gly Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Glu Cys Lys Trp Pro Gly Cys Glu Thr Leu Cys Glu Asp Leu Gly 
305                 310                 315                 320 


Gln Phe Ile Lys His Leu Asn Thr Glu His Ala Leu Asp Asp Arg Ser 
                325                 330                 335     


Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Ile 
            340                 345                 350         


Gln Leu Ala Lys Glu Ser Glu Arg Leu Gln Ala Met Met Ala His Leu 
        355                 360                 365             


His Met Arg Pro Ser Glu Pro Lys Pro Phe Ser Gln Pro Leu Asn Pro 
    370                 375                 380                 


Val Pro Gly Ser Ser Ser Phe Ser Lys Val Thr Val Ser Ala Ala Asp 
385                 390                 395                 400 


Ser Phe Pro Asp Gly Leu Val His Pro Pro Thr Ser Ala Ala Ala Pro 
                405                 410                 415     


Val Thr Pro Leu Arg Pro Pro Gly Leu Gly Ser Ala Ser Leu His Gly 
            420                 425                 430         


Gly Gly Pro Ala Arg Arg Arg Ser Ser Asp Lys Phe Cys Ser Pro Ile 
        435                 440                 445             


Ser Ser Glu Leu Ala Gln Asn His Glu Phe Tyr Lys Asn Ala Asp Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Thr Pro Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Thr Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Arg Glu Tyr Gln Lys Arg 
    530                 535                 540                 


Arg Pro Pro Lys Met Thr Gly Ser Pro Thr Leu Val Lys Asn Met Ile 
545                 550                 555                 560 


Ser Gly Leu Ser Tyr Gly Ala Leu Asn Ala Ser Tyr Gln Ala Ala Leu 
                565                 570                 575     


Ala Glu Ser Ser Phe Pro Leu Leu Asn Ser Pro Gly Met Leu Asn Pro 
            580                 585                 590         


Gly Ser Ala Ser Ser Leu Leu Pro Leu Ser His Asp Asp Val Gly Ala 
        595                 600                 605             


Pro Val Glu Pro Leu Pro Ser Asn Gly Ser Ser Ser Pro Pro Arg Leu 
    610                 615                 620                 


Ser Pro Pro Gln Tyr Ser His Gln Val Gln Val Lys Glu Glu Pro Ala 
625                 630                 635                 640 


Glu Ala Glu Glu Asp Arg Gln Pro Gly Pro Pro Leu Gly Ala Pro Asn 
                645                 650                 655     


Pro Ser Ala Ser Gly Pro Pro Glu Asp Arg Asp Leu Glu Glu Glu Leu 
            660                 665                 670         


Pro Gly Glu Glu Leu Ser 
        675             


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FoxP3(P1) forward primer

<400>  37
aaagatagta cgttgtccgc ag                                                22


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FoxP3(P1) reverse primer

<400>  38
atttgcaccc tgcattgcgc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL10 forward primer

<400>  39
tctgtgctgc ctcgtgctcc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL10 reverse primer

<400>  40
tctgacagag cctggcaccc                                                   20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDH forward primer

<400>  41
tccactcacg gcaaattcaa c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDH reverse primer

<400>  42
cgctcctgga agatggtgat g                                                 21


<210>  43
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  43

Met Ala Pro Tyr Pro Leu Gln 
1               5           


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  44

Leu Thr Ser Pro Asn Ser Leu 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  45

Met Gly Ser Pro Leu Lys Trp 
1               5           


<210>  46
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  46

Met Gln Ala Arg Gly Asn Trp 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  47

Met Gly Thr Met Pro Leu Asn 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  48

Met Thr Leu Ala Pro Leu Gly 
1               5           


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  49

Leu Gln Pro Pro Trp His Leu 
1               5           


<210>  50
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  50

Met Thr Ile Pro Leu Ser Pro 
1               5           


<210>  51
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  51

Leu Thr Leu Pro Pro Gln Val 
1               5           


<210>  52
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  52

Met Ser Leu Asn Asn Leu Pro 
1               5           


<210>  53
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  53

Leu Ala Thr Pro Pro Lys Pro 
1               5           


<210>  54
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  54

Leu Ser Lys Met Pro Val Ala 
1               5           


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  55

Met Ala Val Pro Arg Pro Leu 
1               5           


<210>  56
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  56

Leu Thr Arg Val Pro Val Gly 
1               5           


<210>  57
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  57

Met Ala Thr Ser Pro Leu Arg 
1               5           


<210>  58
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  58

Met Ser Trp Pro Pro Arg Thr 
1               5           


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  59

Phe Gln Thr Pro Pro Gln Leu 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  60

Met Thr Ala Pro Pro Ile Gln 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  61

Met Thr Met Pro Pro Leu His 
1               5           


<210>  62
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  62

Met Thr Pro Met Arg Thr Thr 
1               5           


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  63

Met Gln Pro Trp Ser His Pro 
1               5           


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  64

Met Gln Pro Pro Pro Thr Thr 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  65

Leu Ala Ser Pro Leu Arg Pro 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  66

Met Ser Arg Pro Thr Thr Thr 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  67

Ala Pro Pro Asp His Ala Gly 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  68

Met Ala Thr Pro Lys Pro Leu 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  69

Leu Ala His Pro Pro Gln Thr 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  70

Leu Thr Arg Pro Pro Tyr Thr 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  71

Phe Thr Thr Pro Pro Gly Val 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  72

Phe Gln Pro Phe Pro Arg Leu 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  73

Met Ala Asp Pro Arg Tyr Trp 
1               5           


<210>  74
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  74

Leu Ser Ile Pro Pro Lys Ala 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  75

Met Thr Ser Val Pro Pro Gln 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  76

Ser Ala Pro Phe Ser Pro Ala 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  77

Phe Ala Ser Pro Tyr Leu Thr 
1               5           


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  78

Leu Thr Arg Pro Pro Tyr His 
1               5           


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  79

Met Ser Gln Ala Pro Ser Val 
1               5           


<210>  80
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  80

Leu Ala Thr Pro Leu Ala Tyr 
1               5           


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  81

Met Ala Thr His Pro Leu Ser 
1               5           


<210>  82
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  82

Leu Thr Pro Ala Thr Ala Ile 
1               5           


<210>  83
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  83

Leu Ser Arg Ala Pro Gly Trp 
1               5           


<210>  84
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  84

Leu Ser Arg Pro Pro Met Pro 
1               5           


<210>  85
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  85

Met Ser Pro Leu Pro Trp Trp 
1               5           


<210>  86
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  86

Met Thr Pro Leu Trp His Ala 
1               5           


<210>  87
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  87

Met Thr Leu Pro Thr Ile Thr 
1               5           


<210>  88
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  88

Leu Thr Thr Pro Pro Lys Val 
1               5           


<210>  89
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  89

Met Gln Thr Phe Pro Val Ser 
1               5           


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  90

Met Ser Leu Thr Ala Pro Arg 
1               5           


<210>  91
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  91

Met Thr Val Ser Arg Leu Gly 
1               5           


<210>  92
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  92

Leu Thr Arg Pro Leu Thr Val 
1               5           


<210>  93
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  93

Leu Thr Pro Ala Arg Ala Thr 
1               5           


<210>  94
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  94

Phe Ser Ala Val Pro Pro Ser 
1               5           


<210>  95
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  95

Leu Ser Arg Ala Pro Thr Ala 
1               5           


<210>  96
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  96

Leu Ala Gly Thr Ser Ile Leu 
1               5           


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  97

Met Thr Ala Arg Pro Ile Lys 
1               5           


<210>  98
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  98

Leu Gln Ile Pro Pro Leu Leu 
1               5           


<210>  99
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  99

Leu Ser Lys Thr Pro Val Ser 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  100

Met Ser Thr Pro Ala Phe Pro 
1               5           


<210>  101
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  101

Phe Ala Lys Leu Pro Ser Gly 
1               5           


<210>  102
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary LOX-1 targeting peptide

<400>  102

Leu Ser Asn Met Pro Arg Tyr 
1               5           


<210>  103
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  103
cagttgcaaa tcgtgg                                                       16


<210>  104
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  104
aatatgataa tgaggg                                                       16


<210>  105
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  105
gggcggtaat gagat                                                        15


<210>  106
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  106
ctcccagtaa tgagga                                                       16


<210>  107
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  107
tgatcaataa tgaatg                                                       16


<210>  108
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  108
tgtaagctaa ttatct                                                       16


<210>  109
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  109
tcctcctaat tggct                                                        15


<210>  110
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  110
atatatataa tcagg                                                        15


<210>  111
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  111
aagattttaa tgacct                                                       16


<210>  112
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  112
ttaatataat aaataattta ttaatattaa t                                      31


<210>  113
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  113
ggatgaataa tta                                                          13


<210>  114
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  114
aaatgaataa ttt                                                          13


<210>  115
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  115
cttatgcaaa taaggt                                                       16


<210>  116
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  116
gctatgcaaa tagggt                                                       16


<210>  117
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  117
ggcatgcaaa ttcgaa                                                       16


<210>  118
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  118
gtcatgcaaa tctcac                                                       16


<210>  119
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  119
aaatgattaa tgg                                                          13


<210>  120
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  120
atgcaaat                                                                 8


<210>  121
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  121
ttgcaaat                                                                 8


<210>  122
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  122
taatga                                                                   6


<210>  123
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  123
taatta                                                                   6


<210>  124
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  124
taattg                                                                   6


<210>  125
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  125
taatca                                                                   6


<210>  126
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  126
taattt                                                                   6


<210>  127
<211>  735
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV2 VP1

<400>  127

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Thr Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Gln Trp Trp Lys Leu Lys Pro Gly Pro Pro Pro Pro 
            20                  25                  30          


Lys Pro Ala Glu Arg His Lys Asp Asp Ser Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Glu Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Arg Gln Leu Asp Ser Gly Asp Asn Pro Tyr Leu Lys Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Lys Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Pro Val Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu His Ser Pro Val Glu Pro Asp Ser Ser Ser Gly Thr Gly 
145                 150                 155                 160 


Lys Ala Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln Thr 
                165                 170                 175     


Gly Asp Ala Asp Ser Val Pro Asp Pro Gln Pro Leu Gly Gln Pro Pro 
            180                 185                 190         


Ala Ala Pro Ser Gly Leu Gly Thr Asn Thr Met Ala Thr Gly Ser Gly 
        195                 200                 205             


Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Asn Ser 
    210                 215                 220                 


Ser Gly Asn Trp His Cys Asp Ser Thr Trp Met Gly Asp Arg Val Ile 
225                 230                 235                 240 


Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His Leu 
                245                 250                 255     


Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala Ser Asn Asp Asn His Tyr 
            260                 265                 270         


Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His 
        275                 280                 285             


Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp 
    290                 295                 300                 


Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val 
305                 310                 315                 320 


Lys Glu Val Thr Gln Asn Asp Gly Thr Thr Thr Ile Ala Asn Asn Leu 
                325                 330                 335     


Thr Ser Thr Val Gln Val Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr 
            340                 345                 350         


Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp 
        355                 360                 365             


Val Phe Met Val Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser 
    370                 375                 380                 


Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser 
385                 390                 395                 400 


Gln Met Leu Arg Thr Gly Asn Asn Phe Thr Phe Ser Tyr Thr Phe Glu 
                405                 410                 415     


Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg 
            420                 425                 430         


Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr 
        435                 440                 445             


Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser Arg Leu Gln Phe Ser Gln 
    450                 455                 460                 


Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser Arg Asn Trp Leu Pro Gly 
465                 470                 475                 480 


Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys Thr Ser Ala Asp Asn Asn 
                485                 490                 495     


Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr Lys Tyr His Leu Asn Gly 
            500                 505                 510         


Arg Asp Ser Leu Val Asn Pro Gly Pro Ala Met Ala Ser His Lys Asp 
        515                 520                 525             


Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly Val Leu Ile Phe Gly Lys 
    530                 535                 540                 


Gln Gly Ser Glu Lys Thr Asn Val Asp Ile Glu Lys Val Met Ile Thr 
545                 550                 555                 560 


Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro Val Ala Thr Glu Gln Tyr 
                565                 570                 575     


Gly Ser Val Ser Thr Asn Leu Gln Arg Gly Asn Arg Gln Ala Ala Thr 
            580                 585                 590         


Ala Asp Val Asn Thr Gln Gly Val Leu Pro Gly Met Val Trp Gln Asp 
        595                 600                 605             


Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile Pro His Thr 
    610                 615                 620                 


Asp Gly His Phe His Pro Ser Pro Leu Met Gly Gly Phe Gly Leu Lys 
625                 630                 635                 640 


His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val Pro Ala Asn 
                645                 650                 655     


Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe Ala Ser Phe Ile Thr Gln 
            660                 665                 670         


Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu Leu Gln Lys 
        675                 680                 685             


Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr 
    690                 695                 700                 


Asn Lys Ser Val Asn Val Asp Phe Thr Val Asp Thr Asn Gly Val Tyr 
705                 710                 715                 720 


Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
                725                 730                 735 


<210>  128
<211>  598
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV2 VP2

<400>  128

Met Ala Pro Gly Lys Lys Arg Pro Val Glu His Ser Pro Val Glu Pro 
1               5                   10                  15      


Asp Ser Ser Ser Gly Thr Gly Lys Ala Gly Gln Gln Pro Ala Arg Lys 
            20                  25                  30          


Arg Leu Asn Phe Gly Gln Thr Gly Asp Ala Asp Ser Val Pro Asp Pro 
        35                  40                  45              


Gln Pro Leu Gly Gln Pro Pro Ala Ala Pro Ser Gly Leu Gly Thr Asn 
    50                  55                  60                  


Thr Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly 
65                  70                  75                  80  


Ala Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr 
                85                  90                  95      


Trp Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu 
            100                 105                 110         


Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly 
        115                 120                 125             


Ala Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr 
    130                 135                 140                 


Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln 
145                 150                 155                 160 


Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe 
                165                 170                 175     


Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr 
            180                 185                 190         


Thr Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp 
        195                 200                 205             


Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys 
    210                 215                 220                 


Leu Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr 
225                 230                 235                 240 


Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr 
                245                 250                 255     


Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe 
            260                 265                 270         


Thr Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala 
        275                 280                 285             


His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr 
    290                 295                 300                 


Leu Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln 
305                 310                 315                 320 


Ser Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln 
                325                 330                 335     


Ser Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser 
            340                 345                 350         


Lys Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala 
        355                 360                 365             


Thr Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro 
    370                 375                 380                 


Ala Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser 
385                 390                 395                 400 


Gly Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp 
                405                 410                 415     


Ile Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn 
            420                 425                 430         


Pro Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg 
        435                 440                 445             


Gly Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu 
    450                 455                 460                 


Pro Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile 
465                 470                 475                 480 


Trp Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu 
                485                 490                 495     


Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys 
            500                 505                 510         


Asn Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys 
        515                 520                 525             


Phe Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu 
    530                 535                 540                 


Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu 
545                 550                 555                 560 


Ile Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr 
                565                 570                 575     


Val Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg 
            580                 585                 590         


Tyr Leu Thr Arg Asn Leu 
        595             


<210>  129
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV2 VP3

<400>  129

Met Ala Thr Gly Ser Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Asn Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Met Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Ser Gln Ser Gly Ala 
    50                  55                  60                  


Ser Asn Asp Asn His Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe 
65                  70                  75                  80  


Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg 
                85                  90                  95      


Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys 
            100                 105                 110         


Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Asp Gly Thr Thr 
        115                 120                 125             


Thr Ile Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser 
    130                 135                 140                 


Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu 
145                 150                 155                 160 


Pro Pro Phe Pro Ala Asp Val Phe Met Val Pro Gln Tyr Gly Tyr Leu 
                165                 170                 175     


Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys 
            180                 185                 190         


Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Thr 
        195                 200                 205             


Phe Ser Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His 
    210                 215                 220                 


Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu 
225                 230                 235                 240 


Tyr Tyr Leu Ser Arg Thr Asn Thr Pro Ser Gly Thr Thr Thr Gln Ser 
                245                 250                 255     


Arg Leu Gln Phe Ser Gln Ala Gly Ala Ser Asp Ile Arg Asp Gln Ser 
            260                 265                 270         


Arg Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Lys 
        275                 280                 285             


Thr Ser Ala Asp Asn Asn Asn Ser Glu Tyr Ser Trp Thr Gly Ala Thr 
    290                 295                 300                 


Lys Tyr His Leu Asn Gly Arg Asp Ser Leu Val Asn Pro Gly Pro Ala 
305                 310                 315                 320 


Met Ala Ser His Lys Asp Asp Glu Glu Lys Phe Phe Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Ile Phe Gly Lys Gln Gly Ser Glu Lys Thr Asn Val Asp Ile 
            340                 345                 350         


Glu Lys Val Met Ile Thr Asp Glu Glu Glu Ile Arg Thr Thr Asn Pro 
        355                 360                 365             


Val Ala Thr Glu Gln Tyr Gly Ser Val Ser Thr Asn Leu Gln Arg Gly 
    370                 375                 380                 


Asn Arg Gln Ala Ala Thr Ala Asp Val Asn Thr Gln Gly Val Leu Pro 
385                 390                 395                 400 


Gly Met Val Trp Gln Asp Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp 
                405                 410                 415     


Ala Lys Ile Pro His Thr Asp Gly His Phe His Pro Ser Pro Leu Met 
            420                 425                 430         


Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn 
        435                 440                 445             


Thr Pro Val Pro Ala Asn Pro Ser Thr Thr Phe Ser Ala Ala Lys Phe 
    450                 455                 460                 


Ala Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile 
465                 470                 475                 480 


Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile 
                485                 490                 495     


Gln Tyr Thr Ser Asn Tyr Asn Lys Ser Val Asn Val Asp Phe Thr Val 
            500                 505                 510         


Asp Thr Asn Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr 
        515                 520                 525             


Leu Thr Arg Asn Leu 
    530             


<210>  130
<211>  738
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV8 VP1

<400>  130

Met Ala Ala Asp Gly Tyr Leu Pro Asp Trp Leu Glu Asp Asn Leu Ser 
1               5                   10                  15      


Glu Gly Ile Arg Glu Trp Trp Ala Leu Lys Pro Gly Ala Pro Lys Pro 
            20                  25                  30          


Lys Ala Asn Gln Gln Lys Gln Asp Asp Gly Arg Gly Leu Val Leu Pro 
        35                  40                  45              


Gly Tyr Lys Tyr Leu Gly Pro Phe Asn Gly Leu Asp Lys Gly Glu Pro 
    50                  55                  60                  


Val Asn Ala Ala Asp Ala Ala Ala Leu Glu His Asp Lys Ala Tyr Asp 
65                  70                  75                  80  


Gln Gln Leu Gln Ala Gly Asp Asn Pro Tyr Leu Arg Tyr Asn His Ala 
                85                  90                  95      


Asp Ala Glu Phe Gln Glu Arg Leu Gln Glu Asp Thr Ser Phe Gly Gly 
            100                 105                 110         


Asn Leu Gly Arg Ala Val Phe Gln Ala Lys Lys Arg Val Leu Glu Pro 
        115                 120                 125             


Leu Gly Leu Val Glu Glu Gly Ala Lys Thr Ala Pro Gly Lys Lys Arg 
    130                 135                 140                 


Pro Val Glu Pro Ser Pro Gln Arg Ser Pro Asp Ser Ser Thr Gly Ile 
145                 150                 155                 160 


Gly Lys Lys Gly Gln Gln Pro Ala Arg Lys Arg Leu Asn Phe Gly Gln 
                165                 170                 175     


Thr Gly Asp Ser Glu Ser Val Pro Asp Pro Gln Pro Leu Gly Glu Pro 
            180                 185                 190         


Pro Ala Ala Pro Ser Gly Val Gly Pro Asn Thr Met Ala Ala Gly Gly 
        195                 200                 205             


Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala Asp Gly Val Gly Ser 
    210                 215                 220                 


Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp Leu Gly Asp Arg Val 
225                 230                 235                 240 


Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro Thr Tyr Asn Asn His 
                245                 250                 255     


Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly Gly Ala Thr Asn Asp 
            260                 265                 270         


Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn 
        275                 280                 285             


Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn 
    290                 295                 300                 


Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser Phe Lys Leu Phe Asn 
305                 310                 315                 320 


Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly Thr Lys Thr Ile Ala 
                325                 330                 335     


Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr Asp Ser Glu Tyr Gln 
            340                 345                 350         


Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly Cys Leu Pro Pro Phe 
        355                 360                 365             


Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn 
    370                 375                 380                 


Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr 
385                 390                 395                 400 


Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Thr Tyr 
                405                 410                 415     


Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr Ala His Ser Gln Ser 
            420                 425                 430         


Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu 
        435                 440                 445             


Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn Thr Gln Thr Leu Gly 
    450                 455                 460                 


Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn Gln Ala Lys Asn Trp 
465                 470                 475                 480 


Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val Ser Thr Thr Thr Gly 
                485                 490                 495     


Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala Gly Thr Lys Tyr His 
            500                 505                 510         


Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly Ile Ala Met Ala Thr 
        515                 520                 525             


His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser Asn Gly Ile Leu Ile 
    530                 535                 540                 


Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala Asp Tyr Ser Asp Val 
545                 550                 555                 560 


Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr Asn Pro Val Ala Thr 
                565                 570                 575     


Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln Gln Gln Asn Thr Ala 
            580                 585                 590         


Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala Leu Pro Gly Met Val 
        595                 600                 605             


Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro Ile Trp Ala Lys Ile 
    610                 615                 620                 


Pro His Thr Asp Gly Asn Phe His Pro Ser Pro Leu Met Gly Gly Phe 
625                 630                 635                 640 


Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile Lys Asn Thr Pro Val 
                645                 650                 655     


Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser Lys Leu Asn Ser Phe 
            660                 665                 670         


Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val Glu Ile Glu Trp Glu 
        675                 680                 685             


Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro Glu Ile Gln Tyr Thr 
    690                 695                 700                 


Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe Ala Val Asn Thr Glu 
705                 710                 715                 720 


Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr Arg Tyr Leu Thr Arg 
                725                 730                 735     


Asn Leu 
        


<210>  131
<211>  601
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV8 VP2

<400>  131

Met Ala Pro Gly Lys Lys Arg Pro Val Glu Pro Ser Pro Gln Arg Ser 
1               5                   10                  15      


Pro Asp Ser Ser Thr Gly Ile Gly Lys Lys Gly Gln Gln Pro Ala Arg 
            20                  25                  30          


Lys Arg Leu Asn Phe Gly Gln Thr Gly Asp Ser Glu Ser Val Pro Asp 
        35                  40                  45              


Pro Gln Pro Leu Gly Glu Pro Pro Ala Ala Pro Ser Gly Val Gly Pro 
    50                  55                  60                  


Asn Thr Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu 
65                  70                  75                  80  


Gly Ala Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser 
                85                  90                  95      


Thr Trp Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala 
            100                 105                 110         


Leu Pro Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr 
        115                 120                 125             


Ser Gly Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro 
    130                 135                 140                 


Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg 
145                 150                 155                 160 


Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg 
                165                 170                 175     


Leu Ser Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn 
            180                 185                 190         


Glu Gly Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val 
        195                 200                 205             


Phe Thr Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His 
    210                 215                 220                 


Gln Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln 
225                 230                 235                 240 


Tyr Gly Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser 
                245                 250                 255     


Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly 
            260                 265                 270         


Asn Asn Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser 
        275                 280                 285             


Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile 
    290                 295                 300                 


Asp Gln Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr 
305                 310                 315                 320 


Ala Asn Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met 
                325                 330                 335     


Ala Asn Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln 
            340                 345                 350         


Arg Val Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp 
        355                 360                 365             


Thr Ala Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn 
    370                 375                 380                 


Pro Gly Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe 
385                 390                 395                 400 


Pro Ser Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp 
                405                 410                 415     


Asn Ala Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys 
            420                 425                 430         


Thr Thr Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn 
        435                 440                 445             


Leu Gln Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln 
    450                 455                 460                 


Gly Ala Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln 
465                 470                 475                 480 


Gly Pro Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro 
                485                 490                 495     


Ser Pro Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile 
            500                 505                 510         


Leu Ile Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn 
        515                 520                 525             


Gln Ser Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val 
    530                 535                 540                 


Ser Val Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp 
545                 550                 555                 560 


Asn Pro Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val 
                565                 570                 575     


Asp Phe Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile 
            580                 585                 590         


Gly Thr Arg Tyr Leu Thr Arg Asn Leu 
        595                 600     


<210>  132
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: AAV8 VP3

<400>  132

Met Ala Ala Gly Gly Gly Ala Pro Met Ala Asp Asn Asn Glu Gly Ala 
1               5                   10                  15      


Asp Gly Val Gly Ser Ser Ser Gly Asn Trp His Cys Asp Ser Thr Trp 
            20                  25                  30          


Leu Gly Asp Arg Val Ile Thr Thr Ser Thr Arg Thr Trp Ala Leu Pro 
        35                  40                  45              


Thr Tyr Asn Asn His Leu Tyr Lys Gln Ile Ser Asn Gly Thr Ser Gly 
    50                  55                  60                  


Gly Ala Thr Asn Asp Asn Thr Tyr Phe Gly Tyr Ser Thr Pro Trp Gly 
65                  70                  75                  80  


Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp 
                85                  90                  95      


Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Ser 
            100                 105                 110         


Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val Thr Gln Asn Glu Gly 
        115                 120                 125             


Thr Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr Ile Gln Val Phe Thr 
    130                 135                 140                 


Asp Ser Glu Tyr Gln Leu Pro Tyr Val Leu Gly Ser Ala His Gln Gly 
145                 150                 155                 160 


Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly 
                165                 170                 175     


Tyr Leu Thr Leu Asn Asn Gly Ser Gln Ala Val Gly Arg Ser Ser Phe 
            180                 185                 190         


Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn 
        195                 200                 205             


Phe Gln Phe Thr Tyr Thr Phe Glu Asp Val Pro Phe His Ser Ser Tyr 
    210                 215                 220                 


Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln 
225                 230                 235                 240 


Tyr Leu Tyr Tyr Leu Ser Arg Thr Gln Thr Thr Gly Gly Thr Ala Asn 
                245                 250                 255     


Thr Gln Thr Leu Gly Phe Ser Gln Gly Gly Pro Asn Thr Met Ala Asn 
            260                 265                 270         


Gln Ala Lys Asn Trp Leu Pro Gly Pro Cys Tyr Arg Gln Gln Arg Val 
        275                 280                 285             


Ser Thr Thr Thr Gly Gln Asn Asn Asn Ser Asn Phe Ala Trp Thr Ala 
    290                 295                 300                 


Gly Thr Lys Tyr His Leu Asn Gly Arg Asn Ser Leu Ala Asn Pro Gly 
305                 310                 315                 320 


Ile Ala Met Ala Thr His Lys Asp Asp Glu Glu Arg Phe Phe Pro Ser 
                325                 330                 335     


Asn Gly Ile Leu Ile Phe Gly Lys Gln Asn Ala Ala Arg Asp Asn Ala 
            340                 345                 350         


Asp Tyr Ser Asp Val Met Leu Thr Ser Glu Glu Glu Ile Lys Thr Thr 
        355                 360                 365             


Asn Pro Val Ala Thr Glu Glu Tyr Gly Ile Val Ala Asp Asn Leu Gln 
    370                 375                 380                 


Gln Gln Asn Thr Ala Pro Gln Ile Gly Thr Val Asn Ser Gln Gly Ala 
385                 390                 395                 400 


Leu Pro Gly Met Val Trp Gln Asn Arg Asp Val Tyr Leu Gln Gly Pro 
                405                 410                 415     


Ile Trp Ala Lys Ile Pro His Thr Asp Gly Asn Phe His Pro Ser Pro 
            420                 425                 430         


Leu Met Gly Gly Phe Gly Leu Lys His Pro Pro Pro Gln Ile Leu Ile 
        435                 440                 445             


Lys Asn Thr Pro Val Pro Ala Asp Pro Pro Thr Thr Phe Asn Gln Ser 
    450                 455                 460                 


Lys Leu Asn Ser Phe Ile Thr Gln Tyr Ser Thr Gly Gln Val Ser Val 
465                 470                 475                 480 


Glu Ile Glu Trp Glu Leu Gln Lys Glu Asn Ser Lys Arg Trp Asn Pro 
                485                 490                 495     


Glu Ile Gln Tyr Thr Ser Asn Tyr Tyr Lys Ser Thr Ser Val Asp Phe 
            500                 505                 510         


Ala Val Asn Thr Glu Gly Val Tyr Ser Glu Pro Arg Pro Ile Gly Thr 
        515                 520                 525             


Arg Tyr Leu Thr Arg Asn Leu 
    530                 535 


