                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Non-Human Animals Having a Humanized CXCL13 Gene

<130>  38357WO (10574WO01)

<150>  63/013,148
<151>  2020-04-21

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  1219
<212>  DNA
<213>  Homo sapiens

<400>  1
gagaagatgt ttgaaaaaac tgactctgct aatgagcctg gactcagagc tcaagtctga       60

actctacctc cagacagaat gaagttcatc tcgacatctc tgcttctcat gctgctggtc      120

agcagcctct ctccagtcca aggtgttctg gaggtctatt acacaagctt gaggtgtaga      180

tgtgtccaag agagctcagt ctttatccct agacgcttca ttgatcgaat tcaaatcttg      240

ccccgtggga atggttgtcc aagaaaagaa atcatagtct ggaagaagaa caagtcaatt      300

gtgtgtgtgg accctcaagc tgaatggata caaagaatga tggaagtatt gagaaaaaga      360

agttcttcaa ctctaccagt tccagtgttt aagagaaaga ttccctgatg ctgatatttc      420

cactaagaac acctgcattc ttcccttatc cctgctctgg attttagttt tgtgcttagt      480

taaatctttt ccaggaaaaa gaacttcccc atacaaataa gcatgagact atgtaaaaat      540

aaccttgcag aagctgatgg ggcaaactca agcttcttca ctcacagcac cctatataca      600

cttggagttt gcattcttat tcatcaggga ggaaagtttc tttgaaaata gttattcagt      660

tataagtaat acaggattat tttgattata tacttgttgt ttaatgttta aaatttctta      720

gaaaacaatg gaatgagaat ttaagcctca aatttgaaca tgtggcttga attaagaaga      780

aaattatggc atatattaaa agcaggcttc tatgaaagac tcaaaaagct gcctgggagg      840

cagatggaac ttgagcctgt caagaggcaa aggaatccat gtagtagata tcctctgctt      900

aaaaactcac tacggaggag aattaagtcc tacttttaaa gaatttcttt ataaaattta      960

ctgtctaaga ttaatagcat tcgaagatcc ccagacttca tagaatactc agggaaagca     1020

tttaaagggt gatgtacaca tgtatccttt cacacatttg ccttgacaaa cttctttcac     1080

tcacatcttt ttcactgact ttttttgtgg ggggcggggc cggggggact ctggtatcta     1140

attctttaat gattcctata aatctaatga cattcaataa agttgagcaa acattttact     1200

taaaaaaaaa aaaaaaaaa                                                  1219


<210>  2
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Phe Ile Ser Thr Ser Leu Leu Leu Met Leu Leu Val Ser Ser 
1               5                   10                  15      


Leu Ser Pro Val Gln Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg 
            20                  25                  30          


Cys Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile 
        35                  40                  45              


Asp Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu 
    50                  55                  60                  


Ile Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln 
65                  70                  75                  80  


Ala Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser 
                85                  90                  95      


Ser Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105                 


<210>  3
<211>  1162
<212>  DNA
<213>  Mus musculus

<400>  3
gagctaaagg ttgaactcca cctccaggca gaatgaggct cagcacagca acgctgcttc       60

tcctcctggc cagctgcctc tctccaggcc acggtattct ggaagcccat tacacaaact      120

taaaatgtag gtgttctgga gtgatttcaa ctgttgtcgg tctaaacatc atagatcgga      180

ttcaagttac gccccctggg aatggctgcc ccaaaactga agttgtgatc tggaccaaga      240

tgaagaaagt tatatgtgtg aatcctcgtg ccaaatggtt acaaagatta ttaagacatg      300

tccaaagcaa aagtctgtct tcaactcccc aagctccagt gagtaagaga agagctgcct      360

gaagccacta tcatctcaaa agacacacct gcaccttttt ttttatccct gctctgaatt      420

ttagatatgt tcttagttaa agaatttcca agaaaataac tcccctctac aaacaaacat      480

gactgtaggt aaaacaaagc aaaaacaaac aagcaaacaa acaaactaaa aaaaacccaa      540

tcctgcagga gctgagaggg aatgctcaag ctccgttgca tacccaaccc acatccttgt      600

tccttaagaa aggctatttg agaacaggca tttagtgaca acccacttca gatgcatgtg      660

gtaatagatc tgttgtttaa tgttaaacta tcctagattg tcgaggaatg aaaaacctac      720

atgtcaaatg tgaacttgta gctcgtacta acaagaggtt tgcgagatgg acttcagtta      780

ttttgcaccc ttgtaaaacg caggcttcca aaatagtctc cagaaggttc ctgggaagct      840

ggtgcaatgc catcatgagg tggtgcaaag caggtctcct ttagagaaaa gcttcctggg      900

ggaaacagtc ctactttgaa aggttgcttg tataagattt attgtcttgc attaaaacca      960

gtaacaattg aaagatcctc agcttaaagg tccaggctct tcagcagtat acaaatatat     1020

tcctttgcac tgtgaccctg atgatctatt tttattattc atatctttca cacagacaaa     1080

ataccagcct cttgtatcag attctttaat gtttcctatt catctggtgt cattcaataa     1140

atgtaatcaa atgttttgct ta                                              1162


<210>  4
<211>  109
<212>  PRT
<213>  Mus musculus

<400>  4

Met Arg Leu Ser Thr Ala Thr Leu Leu Leu Leu Leu Ala Ser Cys Leu 
1               5                   10                  15      


Ser Pro Gly His Gly Ile Leu Glu Ala His Tyr Thr Asn Leu Lys Cys 
            20                  25                  30          


Arg Cys Ser Gly Val Ile Ser Thr Val Val Gly Leu Asn Ile Ile Asp 
        35                  40                  45              


Arg Ile Gln Val Thr Pro Pro Gly Asn Gly Cys Pro Lys Thr Glu Val 
    50                  55                  60                  


Val Ile Trp Thr Lys Met Lys Lys Val Ile Cys Val Asn Pro Arg Ala 
65                  70                  75                  80  


Lys Trp Leu Gln Arg Leu Leu Arg His Val Gln Ser Lys Ser Leu Ser 
                85                  90                  95      


Ser Thr Pro Gln Ala Pro Val Ser Lys Arg Arg Ala Ala 
            100                 105                 


<210>  5
<211>  1138
<212>  DNA
<213>  Rattus norvegicus

<400>  5
gtgaactcca cctccaggca gaatgaggct ctgcaccgca gccctgcttc ttctactggc       60

catctgcctc cctccaggcc acggtattct ggagacccat tacacaaact tgaaatgtag      120

gtgttccaag gtgagctcga cctttatcaa tctaattctc gtagattgga ttcaagttat      180

acgccctggg aatggctgcc ccaaaactga aatcattttc tggaccaagg ccaagaaagc      240

tatatgtgtg aatcctactg ccagatggtt accaaaagta ttaaaatttg tccgaagaag      300

tattacttca actccccaag ctccagtgag taagaaaaga gctgcctgaa gccactgtca      360

ccccaaaaga cacctgcacc ctttcttaat ccctgctcgg aatcttagtg ttacgttctt      420

agttgaagaa tttccaagaa aataacttcc ctctacaaac acggctgtag attaaaagaa      480

aaaaatcctg cagtagctga gaggagacac tcgagctcct tcccatactc aacccatatt      540

cttgttcctt aagggaggat attttcgagc aggcatttag tgacaagcca ctttggtaat      600

agacctgttg tttagtgtta aactatccta gaccctagag gaataaaagc atacatgtcg      660

aatctgaacc catagctcct actaacaaga ggtttatgag atggacttca gttagtttgc      720

acccttgcaa aaatcaggct tccagaatag tttccagaag gtccctaaga agcagacgca      780

ttaccagcct aaggtgatgc agagcaggtc tcctttagag agaatcttca tgagggaaat      840

aatgcttcga ctttgaaagg ttgcttgtac aaaatttatt gtcttggatt aaaaccagta      900

acactgaaag atcctcagct taaagttcca ggctccttaa cagtatacaa atatattcct      960

ttgcactgtg accctgctaa tctattttta ttattcacat ctttcacaca gacaaaatac     1020

cagtctcttg tatcaaattc tttaacgttt cctattcatc cagtgtcatt caataaactt     1080

aatcaaataa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       1138


<210>  6
<211>  108
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Arg Leu Cys Thr Ala Ala Leu Leu Leu Leu Leu Ala Ile Cys Leu 
1               5                   10                  15      


Pro Pro Gly His Gly Ile Leu Glu Thr His Tyr Thr Asn Leu Lys Cys 
            20                  25                  30          


Arg Cys Ser Lys Val Ser Ser Thr Phe Ile Asn Leu Ile Leu Val Asp 
        35                  40                  45              


Trp Ile Gln Val Ile Arg Pro Gly Asn Gly Cys Pro Lys Thr Glu Ile 
    50                  55                  60                  


Ile Phe Trp Thr Lys Ala Lys Lys Ala Ile Cys Val Asn Pro Thr Ala 
65                  70                  75                  80  


Arg Trp Leu Pro Lys Val Leu Lys Phe Val Arg Arg Ser Ile Thr Ser 
                85                  90                  95      


Thr Pro Gln Ala Pro Val Ser Lys Lys Arg Ala Ala 
            100                 105             


<210>  7
<211>  327
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CDS nucleic acid sequence encoding humanized, mouse/human 
       chimeric Cxcl13 protein

<400>  7
atgaggctca gcacagcaac gctgcttctc ctcctggcca gctgcctctc tccaggccac       60

ggtgttctgg aggtctatta cacaagcttg aggtgtagat gtgtccaaga gagctcagtc      120

tttatcccta gacgcttcat tgatcgaatt caaatcttgc cccgtgggaa tggttgtcca      180

agaaaagaaa tcatagtctg gaagaagaac aagtcaattg tgtgtgtgga ccctcaagct      240

gaatggatac aaagaatgat ggaagtattg agaaaaagaa gttcttcaac tctaccagtt      300

ccagtgttta agagaaagat tccctga                                          327


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized, mouse/human chimeric Cxcl13 protein

<400>  8

Met Arg Leu Ser Thr Ala Thr Leu Leu Leu Leu Leu Ala Ser Cys Leu 
1               5                   10                  15      


Ser Pro Gly His Gly Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg Cys 
            20                  25                  30          


Arg Cys Val Gln Glu Ser Ser Val Phe Ile Pro Arg Arg Phe Ile Asp 
        35                  40                  45              


Arg Ile Gln Ile Leu Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu Ile 
    50                  55                  60                  


Ile Val Trp Lys Lys Asn Lys Ser Ile Val Cys Val Asp Pro Gln Ala 
65                  70                  75                  80  


Glu Trp Ile Gln Arg Met Met Glu Val Leu Arg Lys Arg Ser Ser Ser 
                85                  90                  95      


Thr Leu Pro Val Pro Val Phe Lys Arg Lys Ile Pro 
            100                 105             


<210>  9
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  9
ttacaggtgt tctggaggtc ta                                                22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  10
cgatcaatga agcgtctagg gat                                               23


<210>  11
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  11
acacaagctt gaggtgtaga tgtgtcca                                          28


<210>  12
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  12
gcctgaccaa catggagaaa c                                                 21


<210>  13
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  13
gcctcagcct cccaagtag                                                    19


<210>  14
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  14
tacaaaatta gccgggtgtg gtggt                                             25


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  15
cctcgcagct ttggattcaa c                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  16
gggcagtttg ggatctggaa t                                                 21


<210>  17
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  17
tgttccacaa atggttgttc tcttattcc                                         29


<210>  18
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  18
ggcatcaaac tcagagatgt gaag                                              24


<210>  19
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  19
gacaggcaag agaccagtca t                                                 21


<210>  20
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  20
tctagccatg acctacttgg gagtagt                                           27


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  21
tcggttctac gtctatgttc tttg                                              24


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  22
gggcttccag aatacctgtg aac                                               23


<210>  23
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe primer

<400>  23
tccaatgggt tgaagtgtct gactc                                             25


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  24
tgcacagcag ccatcatttg                                                   20


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  25
caggcagctc ttctcttact ca                                                22


<210>  26
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  26
tgccactaga ggaaagctat ggtttcc                                           27


<210>  27
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer

<400>  27
tgcggccgat cttagcc                                                      17


<210>  28
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer

<400>  28
ttgaccgatt ccttgcgg                                                     18


<210>  29
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide probe

<400>  29
acgagcgggt tcggcccatt c                                                 21


