                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
       LI, Hojun
       CONNELLY, Guinevere
 
<120>  Rapid, Point of Care Detection of Neutralizing Antibodies Against
        a Virus

<130>  4041.3052 WO

<140>  PCT/US21/25852
<141>  2021-04-06

<150>  US63/060,724
<151>  2020-08-04

<150>  US63/014,886
<151>  2020-04-24

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  629
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Arg Val 
1               5                   10                  15      


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
            20                  25                  30          


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
        35                  40                  45              


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
    50                  55                  60                  


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
65                  70                  75                  80  


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
                85                  90                  95      


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
            100                 105                 110         


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
        115                 120                 125             


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
    130                 135                 140                 


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
145                 150                 155                 160 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
                165                 170                 175     


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
            180                 185                 190         


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
        195                 200                 205             


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
    210                 215                 220                 


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Ser Arg His 
225                 230                 235                 240 


His His His His His His His Asp Tyr Lys Asp Asp Asp Asp Lys Trp 
                245                 250                 255     


Ser His Pro Gln Phe Glu Lys Gly Gly Asp Tyr Lys Asp Asp Asp Asp 
            260                 265                 270         


Lys Ser Ala Trp Ser His Pro Gln Phe Glu Lys Ser Arg Leu Glu Glu 
        275                 280                 285             


Glu Leu Arg Arg Arg Leu Thr Glu Leu Leu Pro Lys Asn Tyr His Leu 
    290                 295                 300                 


Glu Asn Glu Val Ala Arg Leu Lys Lys Leu Val Gly Glu Arg Met Gln 
305                 310                 315                 320 


Leu Thr Pro Thr Phe Tyr Asp Asn Ser Cys Pro Asn Val Ser Asn Ile 
                325                 330                 335     


Val Arg Asp Thr Ile Val Asn Glu Leu Arg Ser Asp Pro Arg Ile Ala 
            340                 345                 350         


Ala Ser Ile Leu Arg Leu His Phe His Asp Cys Phe Val Asn Gly Cys 
        355                 360                 365             


Asp Ala Ser Ile Leu Leu Asp Asn Thr Thr Ser Phe Arg Thr Glu Lys 
    370                 375                 380                 


Asp Ala Phe Gly Asn Ala Asn Ser Ala Arg Gly Phe Pro Val Ile Asp 
385                 390                 395                 400 


Arg Met Lys Ala Ala Val Glu Ser Ala Cys Pro Arg Thr Val Ser Cys 
                405                 410                 415     


Ala Asp Leu Leu Thr Ile Ala Ala Gln Gln Ser Val Thr Leu Ala Gly 
            420                 425                 430         


Gly Pro Ser Trp Arg Val Pro Leu Gly Arg Arg Asp Ser Leu Gln Ala 
        435                 440                 445             


Phe Leu Asp Leu Ala Asn Ala Asn Leu Pro Ala Pro Phe Phe Thr Leu 
    450                 455                 460                 


Pro Gln Leu Lys Asp Ser Phe Arg Asn Val Gly Leu Asn Arg Ser Ser 
465                 470                 475                 480 


Asp Leu Val Ala Leu Ser Gly Gly His Thr Phe Gly Lys Ser Gln Cys 
                485                 490                 495     


Arg Phe Ile Met Asp Arg Leu Tyr Asn Phe Ser Asn Thr Gly Leu Pro 
            500                 505                 510         


Asp Pro Thr Leu Asn Thr Thr Tyr Leu Gln Thr Leu Arg Gly Leu Cys 
        515                 520                 525             


Pro Leu Asn Gly Asn Leu Ser Ala Leu Val Asp Phe Asp Leu Arg Thr 
    530                 535                 540                 


Pro Thr Ile Phe Asp Asn Lys Tyr Tyr Val Asn Leu Glu Glu Gln Lys 
545                 550                 555                 560 


Gly Leu Ile Gln Ser Asp Gln Glu Leu Phe Ser Ser Pro Asn Ala Thr 
                565                 570                 575     


Asp Thr Ile Pro Leu Val Arg Ser Phe Ala Asn Ser Thr Gln Thr Phe 
            580                 585                 590         


Phe Asn Ala Phe Val Glu Ala Met Asp Arg Met Gly Asn Ile Thr Pro 
        595                 600                 605             


Leu Thr Gly Thr Gln Gly Gln Ile Arg Leu Asn Cys Arg Val Val Asn 
    610                 615                 620                 


Ser Asn Ser Asp Leu 
625                 


<210>  2
<211>  1602
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Ala Ser Val Ala Ser Gln Ser 
        675                 680                 685             


Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr 
    690                 695                 700                 


Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr 
705                 710                 715                 720 


Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr 
                725                 730                 735     


Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln 
            740                 745                 750         


Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala 
        755                 760                 765             


Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln 
    770                 775                 780                 


Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser 
785                 790                 795                 800 


Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
                805                 810                 815     


Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys 
            820                 825                 830         


Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys 
        835                 840                 845             


Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp 
    850                 855                 860                 


Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr 
865                 870                 875                 880 


Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala 
                885                 890                 895     


Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val 
            900                 905                 910         


Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile 
        915                 920                 925             


Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys 
    930                 935                 940                 


Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val 
945                 950                 955                 960 


Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp 
                965                 970                 975     


Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln Ile Asp Arg 
            980                 985                 990         


Leu Ile Thr Gly Arg Leu Gln Ser  Leu Gln Thr Tyr Val  Thr Gln Gln 
        995                 1000                 1005             


Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser Ala Asn  Leu Ala Ala 
    1010                 1015                 1020             


Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln Ser Lys  Arg Val Asp 
    1025                 1030                 1035             


Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser Phe Pro  Gln Ser Ala 
    1040                 1045                 1050             


Pro His  Gly Val Val Phe Leu  His Val Thr Tyr Val  Pro Ala Gln 
    1055                 1060                 1065             


Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile Cys His  Asp Gly Lys 
    1070                 1075                 1080             


Ala His  Phe Pro Arg Glu Gly  Val Phe Val Ser Asn  Gly Thr His 
    1085                 1090                 1095             


Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu Pro Gln  Ile Ile Thr 
    1100                 1105                 1110             


Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys Asp Val  Val Ile Gly 
    1115                 1120                 1125             


Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu Gln Pro  Glu Leu Asp 
    1130                 1135                 1140             


Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe Lys Asn  His Thr Ser 
    1145                 1150                 1155             


Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly Ile Asn  Ala Ser Val 
    1160                 1165                 1170             


Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu Asn Glu  Val Ala Lys 
    1175                 1180                 1185             


Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln Glu Leu  Gly Lys Tyr 
    1190                 1195                 1200             


Glu Gln  Tyr Ile Lys Trp Pro  Ser Arg His His His  His His His 
    1205                 1210                 1215             


His His  Asp Tyr Lys Asp Asp  Asp Asp Lys Trp Ser  His Pro Gln 
    1220                 1225                 1230             


Phe Glu  Lys Gly Gly Asp Tyr  Lys Asp Asp Asp Asp  Lys Ser Ala 
    1235                 1240                 1245             


Trp Ser  His Pro Gln Phe Glu  Lys Ser Arg Leu Glu  Glu Glu Leu 
    1250                 1255                 1260             


Arg Arg  Arg Leu Thr Glu Leu  Leu Pro Lys Asn Tyr  His Leu Glu 
    1265                 1270                 1275             


Asn Glu  Val Ala Arg Leu Lys  Lys Leu Val Gly Glu  Arg Met Gln 
    1280                 1285                 1290             


Leu Thr  Pro Thr Phe Tyr Asp  Asn Ser Cys Pro Asn  Val Ser Asn 
    1295                 1300                 1305             


Ile Val  Arg Asp Thr Ile Val  Asn Glu Leu Arg Ser  Asp Pro Arg 
    1310                 1315                 1320             


Ile Ala  Ala Ser Ile Leu Arg  Leu His Phe His Asp  Cys Phe Val 
    1325                 1330                 1335             


Asn Gly  Cys Asp Ala Ser Ile  Leu Leu Asp Asn Thr  Thr Ser Phe 
    1340                 1345                 1350             


Arg Thr  Glu Lys Asp Ala Phe  Gly Asn Ala Asn Ser  Ala Arg Gly 
    1355                 1360                 1365             


Phe Pro  Val Ile Asp Arg Met  Lys Ala Ala Val Glu  Ser Ala Cys 
    1370                 1375                 1380             


Pro Arg  Thr Val Ser Cys Ala  Asp Leu Leu Thr Ile  Ala Ala Gln 
    1385                 1390                 1395             


Gln Ser  Val Thr Leu Ala Gly  Gly Pro Ser Trp Arg  Val Pro Leu 
    1400                 1405                 1410             


Gly Arg  Arg Asp Ser Leu Gln  Ala Phe Leu Asp Leu  Ala Asn Ala 
    1415                 1420                 1425             


Asn Leu  Pro Ala Pro Phe Phe  Thr Leu Pro Gln Leu  Lys Asp Ser 
    1430                 1435                 1440             


Phe Arg  Asn Val Gly Leu Asn  Arg Ser Ser Asp Leu  Val Ala Leu 
    1445                 1450                 1455             


Ser Gly  Gly His Thr Phe Gly  Lys Ser Gln Cys Arg  Phe Ile Met 
    1460                 1465                 1470             


Asp Arg  Leu Tyr Asn Phe Ser  Asn Thr Gly Leu Pro  Asp Pro Thr 
    1475                 1480                 1485             


Leu Asn  Thr Thr Tyr Leu Gln  Thr Leu Arg Gly Leu  Cys Pro Leu 
    1490                 1495                 1500             


Asn Gly  Asn Leu Ser Ala Leu  Val Asp Phe Asp Leu  Arg Thr Pro 
    1505                 1510                 1515             


Thr Ile  Phe Asp Asn Lys Tyr  Tyr Val Asn Leu Glu  Glu Gln Lys 
    1520                 1525                 1530             


Gly Leu  Ile Gln Ser Asp Gln  Glu Leu Phe Ser Ser  Pro Asn Ala 
    1535                 1540                 1545             


Thr Asp  Thr Ile Pro Leu Val  Arg Ser Phe Ala Asn  Ser Thr Gln 
    1550                 1555                 1560             


Thr Phe  Phe Asn Ala Phe Val  Glu Ala Met Asp Arg  Met Gly Asn 
    1565                 1570                 1575             


Ile Thr  Pro Leu Thr Gly Thr  Gln Gly Gln Ile Arg  Leu Asn Cys 
    1580                 1585                 1590             


Arg Val  Val Asn Ser Asn Ser  Asp Leu 
    1595                 1600         


<210>  3
<211>  945
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ser Arg His His His His His His His His Asp Tyr 
            740                 745                 750         


Lys Asp Asp Asp Asp Lys Trp Ser His Pro Gln Phe Glu Lys Gly Gly 
        755                 760                 765             


Asp Tyr Lys Asp Asp Asp Asp Lys Ser Ala Trp Ser His Pro Gln Phe 
    770                 775                 780                 


Glu Lys Pro Val Ser Gly Asn Leu Lys Val Glu Phe Tyr Asn Ser Asn 
785                 790                 795                 800 


Pro Ser Asp Thr Thr Asn Ser Ile Asn Pro Gln Phe Lys Val Thr Asn 
                805                 810                 815     


Thr Gly Ser Ser Ala Ile Asp Leu Ser Lys Leu Thr Leu Arg Tyr Tyr 
            820                 825                 830         


Tyr Thr Val Asp Gly Gln Lys Asp Gln Thr Phe Trp Cys Asp His Ala 
        835                 840                 845             


Ala Ile Ile Gly Ser Asn Gly Ser Tyr Asn Gly Ile Thr Ser Asn Val 
    850                 855                 860                 


Lys Gly Thr Phe Val Lys Met Ser Ser Ser Thr Asn Asn Ala Asp Thr 
865                 870                 875                 880 


Tyr Leu Glu Ile Ser Phe Thr Gly Gly Thr Leu Glu Pro Gly Ala His 
                885                 890                 895     


Val His Ile Gln Gly Arg Phe Ala Lys Asn Asp Trp Ser Asn Tyr Thr 
            900                 905                 910         


Gln Ser Asn Asp Tyr Ser Phe Lys Ser Ala Ser Gln Phe Val Glu Trp 
        915                 920                 925             


Asp Gln Val Thr Pro Tyr Leu Asn Gly Val Leu Val Trp Gly Lys Glu 
    930                 935                 940                 


Pro 
945 


<210>  4
<211>  435
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met His His His His His His His His Gly Gly Gly Met Gly Pro Asp 
1               5                   10                  15      


Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu Thr 
            20                  25                  30          


Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
        35                  40                  45              


Tyr Ala Ser Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
    50                  55                  60                  


Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe Ser 
65                  70                  75                  80  


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
                85                  90                  95      


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn His 
            100                 105                 110         


Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly 
    130                 135                 140                 


Ser Glu Val Lys Leu Val Glu Ser Gly Pro Gly Leu Val Ala Pro Ser 
145                 150                 155                 160 


Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp 
                165                 170                 175     


Tyr Gly Val Asn Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp 
            180                 185                 190         


Leu Gly Val Ile Trp Gly Asp Gly Ile Thr Asp Tyr Asn Ser Ala Leu 
        195                 200                 205             


Lys Ser Arg Leu Ser Val Thr Lys Asp Asn Ser Lys Ser Gln Val Phe 
    210                 215                 220                 


Leu Lys Met Asn Ser Leu Gln Ser Gly Asp Ser Ala Arg Tyr Tyr Cys 
225                 230                 235                 240 


Val Thr Gly Leu Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val 
                245                 250                 255     


Ser Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Ser Gly Pro Val Ser Gly Asn Leu Lys Val Glu Phe Tyr Asn 
        275                 280                 285             


Ser Asn Pro Ser Asp Thr Thr Asn Ser Ile Asn Pro Gln Phe Lys Val 
    290                 295                 300                 


Thr Asn Thr Gly Ser Ser Ala Ile Asp Leu Ser Lys Leu Thr Leu Arg 
305                 310                 315                 320 


Tyr Tyr Tyr Thr Val Asp Gly Gln Lys Asp Gln Thr Phe Trp Cys Asp 
                325                 330                 335     


His Ala Ala Ile Ile Gly Ser Asn Gly Ser Tyr Asn Gly Ile Thr Ser 
            340                 345                 350         


Asn Val Lys Gly Thr Phe Val Lys Met Ser Ser Ser Thr Asn Asn Ala 
        355                 360                 365             


Asp Thr Tyr Leu Glu Ile Ser Phe Thr Gly Gly Thr Leu Glu Pro Gly 
    370                 375                 380                 


Ala His Val His Ile Gln Gly Arg Phe Ala Lys Asn Asp Trp Ser Asn 
385                 390                 395                 400 


Tyr Thr Gln Ser Asn Asp Tyr Ser Phe Lys Ser Ala Ser Gln Phe Val 
                405                 410                 415     


Glu Trp Asp Gln Val Thr Pro Tyr Leu Asn Gly Val Leu Val Trp Gly 
            420                 425                 430         


Lys Glu Pro 
        435 


<210>  5
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met His His His His His His His His Gly Gly Gly Glu Val Gln Leu 
1               5                   10                  15      


Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            20                  25                  30          


Ser Cys Thr Ala Ser Gly Val Thr Ile Ser Ala Leu Asn Ala Met Ala 
        35                  40                  45              


Met Gly Trp Tyr Arg Gln Ala Pro Gly Glu Arg Arg Val Met Val Ala 
    50                  55                  60                  


Ala Val Ser Glu Arg Gly Asn Ala Met Tyr Arg Glu Ser Val Gln Gly 
65                  70                  75                  80  


Arg Phe Thr Val Thr Arg Asp Phe Thr Asn Lys Met Val Ser Leu Gln 
                85                  90                  95      


Met Asp Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys His Val 
            100                 105                 110         


Leu Glu Asp Arg Val Asp Ser Phe His Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Gln Val Thr Val Ser Ser Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Ser Gly Pro Val Ser Gly Asn Leu Lys Val 
145                 150                 155                 160 


Glu Phe Tyr Asn Ser Asn Pro Ser Asp Thr Thr Asn Ser Ile Asn Pro 
                165                 170                 175     


Gln Phe Lys Val Thr Asn Thr Gly Ser Ser Ala Ile Asp Leu Ser Lys 
            180                 185                 190         


Leu Thr Leu Arg Tyr Tyr Tyr Thr Val Asp Gly Gln Lys Asp Gln Thr 
        195                 200                 205             


Phe Trp Cys Asp His Ala Ala Ile Ile Gly Ser Asn Gly Ser Tyr Asn 
    210                 215                 220                 


Gly Ile Thr Ser Asn Val Lys Gly Thr Phe Val Lys Met Ser Ser Ser 
225                 230                 235                 240 


Thr Asn Asn Ala Asp Thr Tyr Leu Glu Ile Ser Phe Thr Gly Gly Thr 
                245                 250                 255     


Leu Glu Pro Gly Ala His Val His Ile Gln Gly Arg Phe Ala Lys Asn 
            260                 265                 270         


Asp Trp Ser Asn Tyr Thr Gln Ser Asn Asp Tyr Ser Phe Lys Ser Ala 
        275                 280                 285             


Ser Gln Phe Val Glu Trp Asp Gln Val Thr Pro Tyr Leu Asn Gly Val 
    290                 295                 300                 


Leu Val Trp Gly Lys Glu Pro 
305                 310     


<210>  6
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met His His His His His His His His Gly Gly Gly Met Leu Pro Lys 
1               5                   10                  15      


Thr Asp Thr Tyr Lys Leu Ile Leu Asn Gly Lys Thr Leu Lys Gly Glu 
            20                  25                  30          


Thr Thr Thr Glu Ala Val Asp Ala Ala Thr Ala Glu Lys Val Phe Lys 
        35                  40                  45              


Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly Glu Trp Thr Tyr Asp Asp 
    50                  55                  60                  


Ala Thr Lys Thr Phe Thr Val Thr Glu Lys Pro Glu Val Ile Asp Ala 
65                  70                  75                  80  


Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr Lys Leu Val Ile Asn Gly 
                85                  90                  95      


Lys Thr Leu Lys Gly Glu Thr Thr Thr Glu Ala Val Asp Ala Ala Thr 
            100                 105                 110         


Ala Glu Lys Val Phe Lys Gln Tyr Ala Asn Asp Asn Gly Val Asp Gly 
        115                 120                 125             


Glu Trp Thr Tyr Asp Asp Ala Thr Lys Thr Phe Thr Val Thr Glu Lys 
    130                 135                 140                 


Pro Glu Val Ile Asp Ala Ser Glu Leu Thr Pro Ala Val Thr Thr Tyr 
145                 150                 155                 160 


Lys Leu Val Ile Asn Gly Lys Thr Leu Lys Gly Glu Thr Thr Thr Lys 
                165                 170                 175     


Ala Val Asp Ala Glu Thr Ala Glu Lys Ala Phe Lys Gln Tyr Ala Asn 
            180                 185                 190         


Asp Asn Gly Val Asp Gly Val Trp Thr Tyr Asp Asp Ala Thr Lys Thr 
        195                 200                 205             


Phe Thr Val Thr Glu Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly 
    210                 215                 220                 


Gly Gly Ser Gly Gly Ser Gly Pro Val Ser Gly Asn Leu Lys Val Glu 
225                 230                 235                 240 


Phe Tyr Asn Ser Asn Pro Ser Asp Thr Thr Asn Ser Ile Asn Pro Gln 
                245                 250                 255     


Phe Lys Val Thr Asn Thr Gly Ser Ser Ala Ile Asp Leu Ser Lys Leu 
            260                 265                 270         


Thr Leu Arg Tyr Tyr Tyr Thr Val Asp Gly Gln Lys Asp Gln Thr Phe 
        275                 280                 285             


Trp Cys Asp His Ala Ala Ile Ile Gly Ser Asn Gly Ser Tyr Asn Gly 
    290                 295                 300                 


Ile Thr Ser Asn Val Lys Gly Thr Phe Val Lys Met Ser Ser Ser Thr 
305                 310                 315                 320 


Asn Asn Ala Asp Thr Tyr Leu Glu Ile Ser Phe Thr Gly Gly Thr Leu 
                325                 330                 335     


Glu Pro Gly Ala His Val His Ile Gln Gly Arg Phe Ala Lys Asn Asp 
            340                 345                 350         


Trp Ser Asn Tyr Thr Gln Ser Asn Asp Tyr Ser Phe Lys Ser Ala Ser 
        355                 360                 365             


Gln Phe Val Glu Trp Asp Gln Val Thr Pro Tyr Leu Asn Gly Val Leu 
    370                 375                 380                 


Val Trp Gly Lys Glu Pro 
385                 390 


