                         SEQUENCE LISTING

<110>  HOUSTON GENE THERAPEUTICS LLC
       HERMONAT, Paul L.
 
<120>  COMPOSITIONS FOR TREATMENT OF VASCULAR DISEASE

<130>  01258-0001-00PCT

<150>  US 63/013,869
<151>  2020-04-22

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  2027
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(2027)
<223>  5' flanking sequence of human NOX1 gene

<400>  1
gttttccata tttaaaagta gtaaattgga taccatacat gaaaatcagc tccaggtgga       60

ttcaaaacat aaatgtaaaa tgcaaaaata taaaatttct agaagaaaat ataaaagagt      120

atcttgatat ctgggtagtg atggatttct aaaacaagac ataaaatgca taaatcataa      180

aagaaatgac tggtaatcag agtgcattaa aattaagaac ttccatttat cagaaaacac      240

tattaagaga ctgaaaagac aagccataaa cataagcaat aaaagattag tataagatta      300

taaacagaac cctaagaatc taaaagcaaa agaaaaacca atagaaagat agaccaaaaa      360

gtagaatagg ctcagaatag gctcttttaa aaagagaaaa ctcaaatggc cagcagttga      420

attaaaagat gctcaaactc attagtaatc agggaaatgc aaattaaaat cataatacga      480

tagttttcca cacttacttg aattataaaa acaaaaaagt ctggaaaata ccaagggttg      540

gtaagcatgt agaggaagta gaactctcat tcataactct ctgtagtata catttaggtg      600

gtcacttcgg aacgggtttg gaattacaca gcaaagtaga atatgtgcaa atctcaggac      660

cctggaattt tactcctggg tatatacctt agagaaactg tagcatatgt gtgacattcg      720

atcaacattg ttccatcatc atatccatca gtagtaggat gaatgaatac attaatgtat      780

attcattcat gcaatggcat attagatagc agtgtaagtg aaccgcaatt acatgtacat      840

gtatgaatct caaaaaccca atgttgaaag aagcaaacca cagaagcata catacacact      900

gccaggtttc atttacaaaa agttcaaaaa caggaaaaac taaacaatat attgcttagg      960

gatgcaatta tagttagtaa aaatataaag aaaaataaca gaatgattac cccaaatttc     1020

aggatagtga ttacatccgg tggggtagag gaggggaaga agatagatgt gatcagggag     1080

ggaaatacaa agagctttaa gatactggag aaaaatagtc tattttcttt aatctgagta     1140

gtgaacacat agatacttat tccttaaaat tattctttaa gttacatatg tatgttttat     1200

atactcttct gtgtatattt caccatttta gaaaagggaa aaaaaatcag tgcccagagc     1260

tgaacacaca actctagtaa atctatcata ctagaagaca atcatctcca ttcttttgag     1320

tgctctgcct ctgtttattt tgaaccaaag tgcactttta tacttgttaa attttctctt     1380

gctctatttg gcccttcttt tcacttgtcc ttccagccag tcaagttctc cccaaagcca     1440

tcatcatata tgtcaaccac agatcatcct ccaggggaac tggtatgcta aagtttctga     1500

gctagccagg ctgaaatcca aatggcagcc ggcagatgtg gcaacagttt gaaaagtgca     1560

ctttgaaaca gcttccttac cacacacgct tccctcccta cttctcctga agtaatctgt     1620

ttacagaccc agactaataa tcttttttat gagaaacttt agcaaatctt ttatctagga     1680

aggcaatgct tcacattagg tcatgttgat aagatgatga gagagaatat tttcatccaa     1740

gaatgttgct atttcctgaa gcagtaaaat ccccacaggt aaaacccttg tggttctcat     1800

agatagggct ggtctatcta agctgatagc acagttctgt ccagagaagg aaggcagaat     1860

aaacttattc attcccagga actcttgggg taggtgtgtg tttttcacat cttaaaggct     1920

cacagaccct gcgctggaca aatgttccat tcctgaagga cctctccaga atccggattg     1980

ctgaatcttc cctgttgcct agaagggctc caaaccacct cttgaca                   2027


<210>  2
<211>  466
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(466)
<223>  Exemplary human NOX1 core promoter

<400>  2
tttgaaacag cttccttacc acacacgctt ccctccctac ttctcctgaa gtaatctgtt       60

tacagaccca gactaataat cttttttatg agaaacttta gcaaatcttt tatctaggaa      120

ggcaatgctt cacattaggt catgttgata agatgatgag agagaatatt ttcatccaag      180

aatgttgcta tttcctgaag cagtaaaatc cccacaggta aaacccttgt ggttctcata      240

gatagggctg gtctatctaa gctgatagca cagttctgtc cagagaagga aggcagaata      300

aacttattca ttcccaggaa ctcttggggt aggtgtgtgt ttttcacatc ttaaaggctc      360

acagaccctg cgctggacaa atgttccatt cctgaaggac ctctccagaa tccggattgc      420

tgaatcttcc ctgttgccta gaagggctcc aaaccacctc ttgaca                     466


<210>  3
<211>  483
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(483)
<223>  Exemplary variant human NOX1 core promoter

<400>  3
tttgaaacag cttccttacc acacacgctt ccctccctac ttctcctgaa gtaatctgtt       60

tacagaccca gactaataat cttttttatg agaaacttta gcaaatcttt tatctaggaa      120

ggccaatgct tcacattagg tcatgttgat aagatgatga gagagaatat tttcatccaa      180

gaatgttgct atttcctgaa gcagtaaaat ccccacaggt aaaacccttg tggttctcat      240

agatagggct ggtctatcta agctgatagc acagttctgt ccagagaagg aaggcagaat      300

aaacttattc attcccagga actcttgggg taggtgtgtg tttttcacat cttaaaggct      360

cacagaccct gcgctggaca aattgttcca ttcctgaagg acctctccag aatccggatt      420

gctgaatctt ccctgttgcc tagaagggct ccaaaccacc tcttgacatg aacgcgtgcc      480

acc                                                                    483


<210>  4
<211>  586
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary variant NOX1 core promoter with three NF-kB 
       binding sequences and two Oct1 binding sequences at the 5' end,  
       eNOX1 promoter

<400>  4
gaggagggga ttcccaagat cgaggagggg attcccaaga tcgaggaggg gattcccaag       60

atcaaaagta tgcaaatccc tgaaaaagta tgcaaatccc tgatttgaaa cagcttcctt      120

accacacacg cttccctccc tacttctcct gaagtaatct gtttacagac ccagactaat      180

aatctttttt atgagaaact ttagcaaatc ttttatctag gaaggccaat gcttcacatt      240

aggtcatgtt gataagatga tgagagagaa tattttcatc caagaatgtt gctatttcct      300

gaagcagtaa aatccccaca ggtaaaaccc ttgtggttct catagatagg gctggtctat      360

ctaagctgat agcacagttc tgtccagaga aggaaggcag aataaactta ttcattccca      420

ggaactcttg gggtaggtgt gtgtttttca catcttaaag gctcacagac cctgcgctgg      480

acaaattgtt ccattcctga aggacctctc cagaatccgg attgctgaat cttccctgtt      540

gcctagaagg gctccaaacc acctcttgac atgaacgcgt gccacc                     586


<210>  5
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(8)
<223>  y is a pyrimidine

<400>  5
gggrnyyycc                                                              10


<210>  6
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  y is a pyrimidine

<400>  6
ggrrnnyycc                                                              10


<210>  7
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is as purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  h is an adenine, a cytosine, or a thymine

<220>
<221>  misc_feature
<222>  (9)..(10)
<223>  y is a pyrimidine

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  b is a guanine, thymine, or cytosine

<400>  7
rggrnnhhyy b                                                            11


<210>  8
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  y is a pyrimidine

<400>  8
ggggatyccc                                                              10


<210>  9
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is any nucleotide

<400>  9
gggrntttcc                                                              10


<210>  10
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (4)..(5)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  w is an adenine or a thymine

<400>  10
nggnnwttcc                                                              10


<210>  11
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary consensus sequence of an NF-kB binding site


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  r is a purine

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  n is any nucleotide

<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  y is a pyrimidine

<400>  11
gggrnnyycc                                                              10


<210>  12
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  12
ggggaatccc c                                                            11


<210>  13
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  13
ggggactttc c                                                            11


<210>  14
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  14
agggggatct g                                                            11


<210>  15
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  15
agggaagtta                                                              10


<210>  16
<211>  11
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  16
ctggggattt a                                                            11


<210>  17
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  17
gggaattccc                                                              10


<210>  18
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of  an NF-kB binding site

<400>  18
gggaatttcc                                                              10


<210>  19
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  19
ggggattccc                                                              10


<210>  20
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an NF-kB binding site

<400>  20
gaggagggga ttcccaagat c                                                 21


<210>  21
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary sequence of an Oct1 binding site

<400>  21
atgcaaat                                                                 8


<210>  22
<211>  1433
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: eNOXpr-3xFLAG-mCherry

<400>  22
gaggagggga ttcccaagat cgaggagggg attcccaaga tcgaggaggg gattcccaag       60

atcaaaagta tgcaaatccc tgaaaaagta tgcaaatccc tgatttgaaa cagcttcctt      120

accacacacg cttccctccc tacttctcct gaagtaatct gtttacagac ccagactaat      180

aatctttttt atgagaaact ttagcaaatc ttttatctag gaaggccaat gcttcacatt      240

aggtcatgtt gataagatga tgagagagaa tattttcatc caagaatgtt gctatttcct      300

gaagcagtaa aatccccaca ggtaaaaccc ttgtggttct catagatagg gctggtctat      360

ctaagctgat agcacagttc tgtccagaga aggaaggcag aataaactta ttcattccca      420

ggaactcttg gggtaggtgt gtgtttttca catcttaaag gctcacagac cctgcgctgg      480

acaaattgtt ccattcctga aggacctctc cagaatccgg attgctgaat cttccctgtt      540

gcctagaagg gctccaaacc acctcttgac atgaacgcgt gccaccatgt ctgactataa      600

agaccatgat ggggactaca aagaccatga tatagattac aaagacgatg atgacaaaat      660

ggttagcaag ggggaggaag acaatatggc cataattaaa gaattcatgc gcttcaaagt      720

tcacatggaa ggaagcgtga acggacatga gttcgagata gaaggcgagg gcgaggggcg      780

gccctatgag ggaacgcaga ctgctaaact gaaggttact aaaggtggcc ctcttccttt      840

cgcatgggac atcctgtctc cgcagttcat gtatggatcc aaggcatatg ttaagcatcc      900

ggctgatata ccagattacc tcaaattgag ctttcctgaa gggtttaagt gggaaagggt      960

catgaacttt gaagacggtg gagttgtgac agttacacag gattcatcac ttcaggacgg     1020

tgagtttata tacaaggtta aacttagggg aactaatttt ccttccgacg gccccgtcat     1080

gcagaaaaaa accatggggt gggaggcgag ctccgagcgg atgtacccag aggatggagc     1140

actgaagggc gaaataaaac agcgactgaa attgaaagac ggaggtcact atgatgcaga     1200

agttaagacg acatacaagg ccaaaaagcc agttcagttg ccgggtgcat ataacgtcaa     1260

tatcaagctg gacattacat cccacaatga ggattatacg atagtggagc agtatgagcg     1320

ggcagaaggg cggcactcca caggaggaat ggacgaactc tataaatgac ccaccagcct     1380

tgtcctaata aaattaagtt gcatcatttt gtttgactac tcgagcccct gca            1433


<210>  23
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: 3xFLAG-mCherry amino acid sequence

<400>  23

Met Ser Asp Tyr Lys Asp His Asp Gly Asp Tyr Lys Asp His Asp Ile 
1               5                   10                  15      


Asp Tyr Lys Asp Asp Asp Asp Lys Met Val Ser Lys Gly Glu Glu Asp 
            20                  25                  30          


Asn Met Ala Ile Ile Lys Glu Phe Met Arg Phe Lys Val His Met Glu 
        35                  40                  45              


Gly Ser Val Asn Gly His Glu Phe Glu Ile Glu Gly Glu Gly Glu Gly 
    50                  55                  60                  


Arg Pro Tyr Glu Gly Thr Gln Thr Ala Lys Leu Lys Val Thr Lys Gly 
65                  70                  75                  80  


Gly Pro Leu Pro Phe Ala Trp Asp Ile Leu Ser Pro Gln Phe Met Tyr 
                85                  90                  95      


Gly Ser Lys Ala Tyr Val Lys His Pro Ala Asp Ile Pro Asp Tyr Leu 
            100                 105                 110         


Lys Leu Ser Phe Pro Glu Gly Phe Lys Trp Glu Arg Val Met Asn Phe 
        115                 120                 125             


Glu Asp Gly Gly Val Val Thr Val Thr Gln Asp Ser Ser Leu Gln Asp 
    130                 135                 140                 


Gly Glu Phe Ile Tyr Lys Val Lys Leu Arg Gly Thr Asn Phe Pro Ser 
145                 150                 155                 160 


Asp Gly Pro Val Met Gln Lys Lys Thr Met Gly Trp Glu Ala Ser Ser 
                165                 170                 175     


Glu Arg Met Tyr Pro Glu Asp Gly Ala Leu Lys Gly Glu Ile Lys Gln 
            180                 185                 190         


Arg Leu Lys Leu Lys Asp Gly Gly His Tyr Asp Ala Glu Val Lys Thr 
        195                 200                 205             


Thr Tyr Lys Ala Lys Lys Pro Val Gln Leu Pro Gly Ala Tyr Asn Val 
    210                 215                 220                 


Asn Ile Lys Leu Asp Ile Thr Ser His Asn Glu Asp Tyr Thr Ile Val 
225                 230                 235                 240 


Glu Gln Tyr Glu Arg Ala Glu Gly Arg His Ser Thr Gly Gly Met Asp 
                245                 250                 255     


Glu Leu Tyr Lys 
            260 


<210>  24
<211>  431
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(431)
<223>  Exemplary wildtype human FoxP3 amino acid sequence

<400>  24

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln 
225                 230                 235                 240 


Ser Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met 
                245                 250                 255     


Gln Ala His Leu Ala Gly Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  25
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Exemplary human FOXP3 zinc finger and leucine zipper region

<400>  25

Glu Lys Gly Arg Ala Gln Cys Leu Leu Gln Arg Glu Met Val Gln Ser 
1               5                   10                  15      


Leu Glu Gln Gln Leu Val Leu Glu Lys Glu Lys Leu Ser Ala Met Gln 
            20                  25                  30          


Ala His Leu Ala Gly Lys 
        35              


<210>  26
<211>  489
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(489)
<223>  Exemplary wildtype human FoxP1 sequence

<400>  26

Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu 
1               5                   10                  15      


Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu Leu Gln Gln 
            20                  25                  30          


Gln Gln Ala Leu Met Leu Gln Leu Gln Gln Leu Trp Lys Glu Val Thr 
        35                  40                  45              


Ser Ala His Thr Ala Glu Glu Thr Thr Gly Asn Asn His Ser Ser Leu 
    50                  55                  60                  


Asp Leu Thr Thr Thr Cys Val Ser Ser Ser Ala Pro Ser Lys Thr Ser 
65                  70                  75                  80  


Leu Ile Met Asn Pro His Ala Ser Thr Asn Gly Gln Leu Ser Val His 
                85                  90                  95      


Thr Pro Lys Arg Glu Ser Leu Ser His Glu Glu His Pro His Ser His 
            100                 105                 110         


Pro Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly Cys Glu Ala Val 
        115                 120                 125             


Cys Glu Asp Phe Gln Ser Phe Leu Lys His Leu Asn Ser Glu His Ala 
    130                 135                 140                 


Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val 
145                 150                 155                 160 


Gln Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala 
                165                 170                 175     


Met Met Thr His Leu His Val Lys Ser Thr Glu Pro Lys Ala Ala Pro 
            180                 185                 190         


Gln Pro Leu Asn Leu Val Ser Ser Val Thr Leu Ser Lys Ser Ala Ser 
        195                 200                 205             


Glu Ala Ser Pro Gln Ser Leu Pro His Thr Pro Thr Thr Pro Thr Ala 
    210                 215                 220                 


Pro Leu Thr Pro Val Thr Gln Gly Pro Ser Val Ile Thr Thr Thr Ser 
225                 230                 235                 240 


Met His Thr Val Gly Pro Ile Arg Arg Arg Tyr Ser Asp Lys Tyr Asn 
                245                 250                 255     


Val Pro Ile Ser Ser Ala Asp Ile Ala Gln Asn Gln Glu Phe Tyr Lys 
            260                 265                 270         


Asn Ala Glu Val Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln 
        275                 280                 285             


Ala Ile Leu Glu Ser Pro Glu Lys Gln Leu Thr Leu Asn Glu Ile Tyr 
    290                 295                 300                 


Asn Trp Phe Thr Arg Met Phe Ala Tyr Phe Arg Arg Asn Ala Ala Thr 
305                 310                 315                 320 


Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val 
                325                 330                 335     


Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp Glu Val Glu 
            340                 345                 350         


Phe Gln Lys Arg Arg Pro Gln Lys Ile Ser Gly Asn Pro Ser Leu Ile 
        355                 360                 365             


Lys Asn Met Gln Ser Ser His Ala Tyr Cys Thr Pro Leu Asn Ala Ala 
    370                 375                 380                 


Leu Gln Ala Ser Met Ala Glu Asn Ser Ile Pro Leu Tyr Thr Thr Ala 
385                 390                 395                 400 


Ser Met Gly Asn Pro Thr Leu Gly Asn Leu Ala Ser Ala Ile Arg Glu 
                405                 410                 415     


Glu Leu Asn Gly Ala Met Glu His Thr Asn Ser Asn Glu Ser Asp Ser 
            420                 425                 430         


Ser Pro Gly Arg Ser Pro Met Gln Ala Val His Pro Val His Val Lys 
        435                 440                 445             


Glu Glu Pro Leu Asp Pro Glu Glu Ala Glu Gly Pro Leu Ser Leu Val 
    450                 455                 460                 


Thr Thr Ala Asn His Ser Pro Asp Phe Asp His Asp Arg Asp Tyr Glu 
465                 470                 475                 480 


Asp Glu Pro Val Asn Glu Asp Met Glu 
                485                 


<210>  27
<211>  38
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(38)
<223>  Exemplary human FOXP1 zinc finger and leucine zipper region

<400>  27

Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln 
1               5                   10                  15      


Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met Met 
            20                  25                  30          


Thr His Leu His Val Lys 
        35              


<210>  28
<211>  431
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary FOXP3(P1) amino acid sequence FOXP1 zinc 
       finger and leucine zipper region underlined

<400>  28

Met Pro Asn Pro Arg Pro Gly Lys Pro Ser Ala Pro Ser Leu Ala Leu 
1               5                   10                  15      


Gly Pro Ser Pro Gly Ala Ser Pro Ser Trp Arg Ala Ala Pro Lys Ala 
            20                  25                  30          


Ser Asp Leu Leu Gly Ala Arg Gly Pro Gly Gly Thr Phe Gln Gly Arg 
        35                  40                  45              


Asp Leu Arg Gly Gly Ala His Ala Ser Ser Ser Ser Leu Asn Pro Met 
    50                  55                  60                  


Pro Pro Ser Gln Leu Gln Leu Pro Thr Leu Pro Leu Val Met Val Ala 
65                  70                  75                  80  


Pro Ser Gly Ala Arg Leu Gly Pro Leu Pro His Leu Gln Ala Leu Leu 
                85                  90                  95      


Gln Asp Arg Pro His Phe Met His Gln Leu Ser Thr Val Asp Ala His 
            100                 105                 110         


Ala Arg Thr Pro Val Leu Gln Val His Pro Leu Glu Ser Pro Ala Met 
        115                 120                 125             


Ile Ser Leu Thr Pro Pro Thr Thr Ala Thr Gly Val Phe Ser Leu Lys 
    130                 135                 140                 


Ala Arg Pro Gly Leu Pro Pro Gly Ile Asn Val Ala Ser Leu Glu Trp 
145                 150                 155                 160 


Val Ser Arg Glu Pro Ala Leu Leu Cys Thr Phe Pro Asn Pro Ser Ala 
                165                 170                 175     


Pro Arg Lys Asp Ser Thr Leu Ser Ala Val Pro Gln Ser Ser Tyr Pro 
            180                 185                 190         


Leu Leu Ala Asn Gly Val Cys Lys Trp Pro Gly Cys Glu Lys Val Phe 
        195                 200                 205             


Glu Glu Pro Glu Asp Phe Leu Lys His Cys Gln Ala Asp His Leu Leu 
    210                 215                 220                 


Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln 
225                 230                 235                 240 


Gln Leu Glu Leu Gln Leu Ala Lys Asp Lys Glu Arg Leu Gln Ala Met 
                245                 250                 255     


Met Thr His Leu His Val Lys Met Ala Leu Thr Lys Ala Ser Ser Val 
            260                 265                 270         


Ala Ser Ser Asp Lys Gly Ser Cys Cys Ile Val Ala Ala Gly Ser Gln 
        275                 280                 285             


Gly Pro Val Val Pro Ala Trp Ser Gly Pro Arg Glu Ala Pro Asp Ser 
    290                 295                 300                 


Leu Phe Ala Val Arg Arg His Leu Trp Gly Ser His Gly Asn Ser Thr 
305                 310                 315                 320 


Phe Pro Glu Phe Leu His Asn Met Asp Tyr Phe Lys Phe His Asn Met 
                325                 330                 335     


Arg Pro Pro Phe Thr Tyr Ala Thr Leu Ile Arg Trp Ala Ile Leu Glu 
            340                 345                 350         


Ala Pro Glu Lys Gln Arg Thr Leu Asn Glu Ile Tyr His Trp Phe Thr 
        355                 360                 365             


Arg Met Phe Ala Phe Phe Arg Asn His Pro Ala Thr Trp Lys Asn Ala 
    370                 375                 380                 


Ile Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Ser 
385                 390                 395                 400 


Glu Lys Gly Ala Val Trp Thr Val Asp Glu Leu Glu Phe Arg Lys Lys 
                405                 410                 415     


Arg Ser Gln Arg Pro Ser Arg Cys Ser Asn Pro Thr Pro Gly Pro 
            420                 425                 430     


<210>  29
<211>  1296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary FoxP3(P1) nucleotide sequence  FoxP1 zinc 
       finger and leucine zipper region underlined

<400>  29
atgccgaatc cccggccagg caagcccagt gccccgtcac ttgcccttgg gcctagtcct       60

ggggcttcac catcctggcg agctgcacct aaggcatctg acctcttggg ggcacgagga      120

ccgggcggga cgtttcaggg aagggacctt agaggcggag ctcatgcaag ctcttcttca      180

ctgaacccga tgccgccgag tcagttgcaa ctccccacac tcccactcgt aatggtggcg      240

ccctctggcg caagactcgg acctctccca cacctgcaag ccctcttgca ggacagacca      300

cacttcatgc accaactttc aacggttgac gcacacgcac ggacaccagt gctgcaagtt      360

catccacttg aatcccctgc catgatcagc ctgacaccgc ctactaccgc gacaggtgtc      420

ttttctttga aagcgaggcc tggattgcca cctggcatca atgtggcgtc cctggagtgg      480

gtttcccgcg aacctgctct cctgtgcaca tttccaaacc cgagtgcgcc gcgaaaagat      540

agtacgttgt ccgcagtacc tcagagctca tatccacttt tggcaaacgg tgtgtgtaaa      600

tggcctggat gcgaaaaagt attcgaagag ccggaggact ttttgaaaca ttgccaagct      660

gaccacctgc tcgatgatcg gtcaaccgcg caatgcaggg tgcaaatgca agttgtacaa      720

cagctcgaat tgcagttggc gaaggacaag gagaggctgc aagcaatgat gacccatctt      780

catgttaaaa tggccctgac caaggcaagc tctgttgcaa gctccgacaa aggctcttgc      840

tgtatcgtag cggcgggatc tcaaggaccg gtcgtcccag cgtggagtgg ccctcgggaa      900

gcccctgata gtcttttcgc cgtgagacgc cacctgtggg gcagccatgg aaactccact      960

tttcctgaat ttttgcacaa tatggactac tttaagttcc ataacatgcg ccccccgttt     1020

acatacgcga cgctcatccg gtgggcaatc ttggaagcgc ctgaaaaaca acgaaccttg     1080

aacgagatat atcattggtt cacgcgaatg ttcgctttct tcagaaatca cccggctact     1140

tggaagaatg ccataagaca caatctttct ctccataaat gctttgtaag ggtcgagtcc     1200

gaaaaagggg cagtatggac tgttgacgag ctggagtttc ggaaaaagcg gtcacaacgc     1260

ccgtcaagat gctcaaaccc taccccaggc ccttga                               1296


<210>  30
<211>  124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary mini-promoter TATA box nucleotide sequence

<400>  30
ttagataaag gctgtctccg cgcctatata aaactcttgt ttttcttttt tctctatcag       60

ttcatttgta gcatcttaat ttactatcct tctactatca gttgccgccg ccgtcgacgc      120

cacc                                                                   124


<210>  31
<211>  178
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(178)
<223>  Exemplary human IL10 amino acid sequence

<400>  31

Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 
1               5                   10                  15      


Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 
            20                  25                  30          


Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 
        35                  40                  45              


Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 
    50                  55                  60                  


Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 
65                  70                  75                  80  


Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 
                85                  90                  95      


Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 
            100                 105                 110         


Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 
        115                 120                 125             


Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 
    130                 135                 140                 


Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 
145                 150                 155                 160 


Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 
                165                 170                 175     


Arg Asn 
        


<210>  32
<211>  537
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(537)
<223>  Exemplary human IL10 nucleotide sequence

<400>  32
atgcactctt ctgcacttct gtgctgcctc gtgctcctga caggtgtcag ggcgagtccc       60

ggtcagggta cgcaatctga aaactcctgc acccactttc cggggaattt gcccaacatg      120

ctgagggatc tgagagacgc tttcagccgc gttaagacat tcttccagat gaaagatcag      180

ctcgataatc ttctgttgaa agagtcactg cttgaggatt ttaaagggta tttggggtgc      240

caggctctgt cagaaatgat acagttctat ctcgaagagg tgatgcctca agcggagaac      300

caagatccag acataaaggc tcacgttaat tccttgggcg agaatctgaa aaccctgagg      360

cttaggctga gacgctgtca tcgcttcttg ccctgtgaaa acaaatccaa agcggtagag      420

caggtcaaaa atgcctttaa taagctgcaa gagaagggga tatataaggc aatgtctgag      480

tttgatatct ttataaacta tatagaagct tacatgacaa tgaaaattcg gaattag         537


<210>  33
<211>  94
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary 5' sequence including polyadenylation, (poly
       A) sequence

<400>  33
ttaattgagg ggccgggctc gagtgcctaa taaaaaacat ttattttcat tgccccctgc       60

agaagcttta aaccggttat cgataatcaa cctc                                   94


<210>  34
<211>  2675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: Exemplary eNOX1pr-FoxP3(P1)-IL10 nucleotide sequence

<400>  34
ggggttcctg cggccgcacg cgtctgcagc ccatgcatga ggaggggatt cccaagatcg       60

aggaggggat tcccaagatc gaggagggga ttcccaagat caaaagtatg caaatccctg      120

aaaaagtatg caaatccctg atttgaaaca gcttccttac cacacacgct tccctcccta      180

cttctcctga agtaatctgt ttacagaccc agactaataa tcttttttat gagaaacttt      240

agcaaatctt ttatctagga aggccaatgc ttcacattag gtcatgttga taagatgatg      300

agagagaata ttttcatcca agaatgttgc tatttcctga agcagtaaaa tccccacagg      360

taaaaccctt gtggttctca tagatagggc tggtctatct aagctgatag cacagttctg      420

tccagagaag gaaggcagaa taaacttatt cattcccagg aactcttggg gtaggtgtgt      480

gtttttcaca tcttaaaggc tcacagaccc tgcgctggac aaattgttcc attcctgaag      540

gacctctcca gaatccggat tgctgaatct tccctgttgc ctagaagggc tccaaaccac      600

ctcttgacat gaacgcgtgc caccatgccg aatccccggc caggcaagcc cagtgccccg      660

tcacttgccc ttgggcctag tcctggggct tcaccatcct ggcgagctgc acctaaggca      720

tctgacctct tgggggcacg aggaccgggc gggacgtttc agggaaggga ccttagaggc      780

ggagctcatg caagctcttc ttcactgaac ccgatgccgc cgagtcagtt gcaactcccc      840

acactcccac tcgtaatggt ggcgccctct ggcgcaagac tcggacctct cccacacctg      900

caagccctct tgcaggacag accacacttc atgcaccaac tttcaacggt tgacgcacac      960

gcacggacac cagtgctgca agttcatcca cttgaatccc ctgccatgat cagcctgaca     1020

ccgcctacta ccgcgacagg tgtcttttct ttgaaagcga ggcctggatt gccacctggc     1080

atcaatgtgg cgtccctgga gtgggtttcc cgcgaacctg ctctcctgtg cacatttcca     1140

aacccgagtg cgccgcgaaa agatagtacg ttgtccgcag tacctcagag ctcatatcca     1200

cttttggcaa acggtgtgtg taaatggcct ggatgcgaaa aagtattcga agagccggag     1260

gactttttga aacattgcca agctgaccac ctgctcgatg atcggtcaac cgcgcaatgc     1320

agggtgcaaa tgcaagttgt acaacagctc gaattgcagt tggcgaagga caaggagagg     1380

ctgcaagcaa tgatgaccca tcttcatgtt aaaatggccc tgaccaaggc aagctctgtt     1440

gcaagctccg acaaaggctc ttgctgtatc gtagcggcgg gatctcaagg accggtcgtc     1500

ccagcgtgga gtggccctcg ggaagcccct gatagtcttt tcgccgtgag acgccacctg     1560

tggggcagcc atggaaactc cacttttcct gaatttttgc acaatatgga ctactttaag     1620

ttccataaca tgcgcccccc gtttacatac gcgacgctca tccggtgggc aatcttggaa     1680

gcgcctgaaa aacaacgaac cttgaacgag atatatcatt ggttcacgcg aatgttcgct     1740

ttcttcagaa atcacccggc tacttggaag aatgccataa gacacaatct ttctctccat     1800

aaatgctttg taagggtcga gtccgaaaaa ggggcagtat ggactgttga cgagctggag     1860

tttcggaaaa agcggtcaca acgcccgtca agatgctcaa accctacccc aggcccttga     1920

ttagataaag gctgtctccg cgcctatata aaactcttgt ttttcttttt tctctatcag     1980

ttcatttgta gcatcttaat ttactatcct tctactatca gttgccgccg ccgtcgacgc     2040

caccatgcac tcttctgcac ttctgtgctg cctcgtgctc ctgacaggtg tcagggcgag     2100

tcccggtcag ggtacgcaat ctgaaaactc ctgcacccac tttccgggga atttgcccaa     2160

catgctgagg gatctgagag acgctttcag ccgcgttaag acattcttcc agatgaaaga     2220

tcagctcgat aatcttctgt tgaaagagtc actgcttgag gattttaaag ggtatttggg     2280

gtgccaggct ctgtcagaaa tgatacagtt ctatctcgaa gaggtgatgc ctcaagcgga     2340

gaaccaagat ccagacataa aggctcacgt taattccttg ggcgagaatc tgaaaaccct     2400

gaggcttagg ctgagacgct gtcatcgctt cttgccctgt gaaaacaaat ccaaagcggt     2460

agagcaggtc aaaaatgcct ttaataagct gcaagagaag gggatatata aggcaatgtc     2520

tgagtttgat atctttataa actatataga agcttacatg acaatgaaaa ttcggaatta     2580

gttaattgag gggccgggct cgagtgccta ataaaaaaca tttattttca ttgccccctg     2640

cagaagcttt aaaccggtta tcgataatca acctc                                2675


<210>  35
<211>  715
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(715)
<223>  Exemplary wildtype human FoxP2 sequence

<400>  35

Met Met Gln Glu Ser Ala Thr Glu Thr Ile Ser Asn Ser Ser Met Asn 
1               5                   10                  15      


Gln Asn Gly Met Ser Thr Leu Ser Ser Gln Leu Asp Ala Gly Ser Arg 
            20                  25                  30          


Asp Gly Arg Ser Ser Gly Asp Thr Ser Ser Glu Val Ser Thr Val Glu 
        35                  40                  45              


Leu Leu His Leu Gln Gln Gln Gln Ala Leu Gln Ala Ala Arg Gln Leu 
    50                  55                  60                  


Leu Leu Gln Gln Gln Thr Ser Gly Leu Lys Ser Pro Lys Ser Ser Asp 
65                  70                  75                  80  


Lys Gln Arg Pro Leu Gln Val Pro Val Ser Val Ala Met Met Thr Pro 
                85                  90                  95      


Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln Gln Val 
            100                 105                 110         


Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln Ala Val 
        115                 120                 125             


Met Leu Gln Gln Gln Gln Leu Gln Glu Phe Tyr Lys Lys Gln Gln Glu 
    130                 135                 140                 


Gln Leu His Leu Gln Leu Leu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
145                 150                 155                 160 


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln 
                165                 170                 175     


Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln Gln His 
            180                 185                 190         


Pro Gly Lys Gln Ala Lys Glu Gln Gln Gln Gln Gln Gln Gln Gln Gln 
        195                 200                 205             


Gln Leu Ala Ala Gln Gln Leu Val Phe Gln Gln Gln Leu Leu Gln Met 
    210                 215                 220                 


Gln Gln Leu Gln Gln Gln Gln His Leu Leu Ser Leu Gln Arg Gln Gly 
225                 230                 235                 240 


Leu Ile Ser Ile Pro Pro Gly Gln Ala Ala Leu Pro Val Gln Ser Leu 
                245                 250                 255     


Pro Gln Ala Gly Leu Ser Pro Ala Glu Ile Gln Gln Leu Trp Lys Glu 
            260                 265                 270         


Val Thr Gly Val His Ser Met Glu Asp Asn Gly Ile Lys His Gly Gly 
        275                 280                 285             


Leu Asp Leu Thr Thr Asn Asn Ser Ser Ser Thr Thr Ser Ser Asn Thr 
    290                 295                 300                 


Ser Lys Ala Ser Pro Pro Ile Thr His His Ser Ile Val Asn Gly Gln 
305                 310                 315                 320 


Ser Ser Val Leu Ser Ala Arg Arg Asp Ser Ser Ser His Glu Glu Thr 
                325                 330                 335     


Gly Ala Ser His Thr Leu Tyr Gly His Gly Val Cys Lys Trp Pro Gly 
            340                 345                 350         


Cys Glu Ser Ile Cys Glu Asp Phe Gly Gln Phe Leu Lys His Leu Asn 
        355                 360                 365             


Asn Glu His Ala Leu Asp Asp Arg Ser Thr Ala Gln Cys Arg Val Gln 
    370                 375                 380                 


Met Gln Val Val Gln Gln Leu Glu Ile Gln Leu Ser Lys Glu Arg Glu 
385                 390                 395                 400 


Arg Leu Gln Ala Met Met Thr His Leu His Met Arg Pro Ser Glu Pro 
                405                 410                 415     


Lys Pro Ser Pro Lys Pro Leu Asn Leu Val Ser Ser Val Thr Met Ser 
            420                 425                 430         


Lys Asn Met Leu Glu Thr Ser Pro Gln Ser Leu Pro Gln Thr Pro Thr 
        435                 440                 445             


Thr Pro Thr Ala Pro Val Thr Pro Ile Thr Gln Gly Pro Ser Val Ile 
    450                 455                 460                 


Thr Pro Ala Ser Val Pro Asn Val Gly Ala Ile Arg Arg Arg His Ser 
465                 470                 475                 480 


Asp Lys Tyr Asn Ile Pro Met Ser Ser Glu Ile Ala Pro Asn Tyr Glu 
                485                 490                 495     


Phe Tyr Lys Asn Ala Asp Val Arg Pro Pro Phe Thr Tyr Ala Thr Leu 
            500                 505                 510         


Ile Arg Gln Ala Ile Met Glu Ser Ser Asp Arg Gln Leu Thr Leu Asn 
        515                 520                 525             


Glu Ile Tyr Ser Trp Phe Thr Arg Thr Phe Ala Tyr Phe Arg Arg Asn 
    530                 535                 540                 


Ala Ala Thr Trp Lys Asn Ala Val Arg His Asn Leu Ser Leu His Lys 
545                 550                 555                 560 


Cys Phe Val Arg Val Glu Asn Val Lys Gly Ala Val Trp Thr Val Asp 
                565                 570                 575     


Glu Val Glu Tyr Gln Lys Arg Arg Ser Gln Lys Ile Thr Gly Ser Pro 
            580                 585                 590         


Thr Leu Val Lys Asn Ile Pro Thr Ser Leu Gly Tyr Gly Ala Ala Leu 
        595                 600                 605             


Asn Ala Ser Leu Gln Ala Ala Leu Ala Glu Ser Ser Leu Pro Leu Leu 
    610                 615                 620                 


Ser Asn Pro Gly Leu Ile Asn Asn Ala Ser Ser Gly Leu Leu Gln Ala 
625                 630                 635                 640 


Val His Glu Asp Leu Asn Gly Ser Leu Asp His Ile Asp Ser Asn Gly 
                645                 650                 655     


Asn Ser Ser Pro Gly Cys Ser Pro Gln Pro His Ile His Ser Ile His 
            660                 665                 670         


Val Lys Glu Glu Pro Val Ile Ala Glu Asp Glu Asp Cys Pro Met Ser 
        675                 680                 685             


Leu Val Thr Thr Ala Asn His Ser Pro Glu Leu Glu Asp Asp Arg Glu 
    690                 695                 700                 


Ile Glu Glu Glu Pro Leu Ser Glu Asp Leu Glu 
705                 710                 715 


<210>  36
<211>  678
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(678)
<223>  Exemplary wildtype human FoxP4 sequence

<400>  36

Met Met Val Glu Ser Ala Ser Glu Thr Ile Arg Ser Ala Pro Ser Gly 
1               5                   10                  15      


Gln Asn Gly Val Gly Ser Leu Ser Gly Gln Ala Asp Gly Ser Ser Gly 
            20                  25                  30          


Gly Ala Thr Gly Thr Thr Ala Ser Gly Thr Gly Arg Glu Val Thr Thr 
        35                  40                  45              


Gly Ala Asp Ser Asn Gly Glu Met Ser Pro Ala Glu Leu Leu His Phe 
    50                  55                  60                  


Gln Gln Gln Gln Ala Leu Gln Val Ala Arg Gln Phe Leu Leu Gln Gln 
65                  70                  75                  80  


Ala Ser Gly Leu Ser Ser Pro Gly Asn Asn Asp Ser Lys Gln Ser Ala 
                85                  90                  95      


Ser Ala Val Gln Val Pro Val Ser Val Ala Met Met Ser Pro Gln Met 
            100                 105                 110         


Leu Thr Pro Gln Gln Met Gln Gln Ile Leu Ser Pro Pro Gln Leu Gln 
        115                 120                 125             


Ala Leu Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Glu Tyr Tyr 
    130                 135                 140                 


Lys Lys Gln Gln Glu Gln Leu His Leu Gln Leu Leu Thr Gln Gln Gln 
145                 150                 155                 160 


Ala Gly Lys Pro Gln Pro Lys Glu Ala Leu Gly Asn Lys Gln Leu Ala 
                165                 170                 175     


Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln His Leu 
            180                 185                 190         


Leu Asn Leu Gln Arg Gln Gly Leu Val Ser Leu Gln Pro Asn Gln Ala 
        195                 200                 205             


Ser Gly Pro Leu Gln Thr Leu Pro Gln Ala Ala Val Cys Pro Thr Asp 
    210                 215                 220                 


Leu Pro Gln Leu Trp Lys Gly Glu Gly Ala Pro Gly Gln Pro Ala Glu 
225                 230                 235                 240 


Asp Ser Val Lys Gln Glu Gly Leu Asp Leu Thr Gly Thr Ala Ala Thr 
                245                 250                 255     


Ala Thr Ser Phe Ala Ala Pro Pro Lys Val Ser Pro Pro Leu Ser His 
            260                 265                 270         


His Thr Leu Pro Asn Gly Gln Pro Thr Val Leu Thr Ser Arg Arg Asp 
        275                 280                 285             


Ser Ser Ser His Glu Glu Thr Pro Gly Ser His Pro Leu Tyr Gly His 
    290                 295                 300                 


Gly Glu Cys Lys Trp Pro Gly Cys Glu Thr Leu Cys Glu Asp Leu Gly 
305                 310                 315                 320 


Gln Phe Ile Lys His Leu Asn Thr Glu His Ala Leu Asp Asp Arg Ser 
                325                 330                 335     


Thr Ala Gln Cys Arg Val Gln Met Gln Val Val Gln Gln Leu Glu Ile 
            340                 345                 350         


Gln Leu Ala Lys Glu Ser Glu Arg Leu Gln Ala Met Met Ala His Leu 
        355                 360                 365             


His Met Arg Pro Ser Glu Pro Lys Pro Phe Ser Gln Pro Leu Asn Pro 
    370                 375                 380                 


Val Pro Gly Ser Ser Ser Phe Ser Lys Val Thr Val Ser Ala Ala Asp 
385                 390                 395                 400 


Ser Phe Pro Asp Gly Leu Val His Pro Pro Thr Ser Ala Ala Ala Pro 
                405                 410                 415     


Val Thr Pro Leu Arg Pro Pro Gly Leu Gly Ser Ala Ser Leu His Gly 
            420                 425                 430         


Gly Gly Pro Ala Arg Arg Arg Ser Ser Asp Lys Phe Cys Ser Pro Ile 
        435                 440                 445             


Ser Ser Glu Leu Ala Gln Asn His Glu Phe Tyr Lys Asn Ala Asp Val 
    450                 455                 460                 


Arg Pro Pro Phe Thr Tyr Ala Ser Leu Ile Arg Gln Ala Ile Leu Glu 
465                 470                 475                 480 


Thr Pro Asp Arg Gln Leu Thr Leu Asn Glu Ile Tyr Asn Trp Phe Thr 
                485                 490                 495     


Arg Met Phe Ala Tyr Phe Arg Arg Asn Thr Ala Thr Trp Lys Asn Ala 
            500                 505                 510         


Val Arg His Asn Leu Ser Leu His Lys Cys Phe Val Arg Val Glu Asn 
        515                 520                 525             


Val Lys Gly Ala Val Trp Thr Val Asp Glu Arg Glu Tyr Gln Lys Arg 
    530                 535                 540                 


Arg Pro Pro Lys Met Thr Gly Ser Pro Thr Leu Val Lys Asn Met Ile 
545                 550                 555                 560 


Ser Gly Leu Ser Tyr Gly Ala Leu Asn Ala Ser Tyr Gln Ala Ala Leu 
                565                 570                 575     


Ala Glu Ser Ser Phe Pro Leu Leu Asn Ser Pro Gly Met Leu Asn Pro 
            580                 585                 590         


Gly Ser Ala Ser Ser Leu Leu Pro Leu Ser His Asp Asp Val Gly Ala 
        595                 600                 605             


Pro Val Glu Pro Leu Pro Ser Asn Gly Ser Ser Ser Pro Pro Arg Leu 
    610                 615                 620                 


Ser Pro Pro Gln Tyr Ser His Gln Val Gln Val Lys Glu Glu Pro Ala 
625                 630                 635                 640 


Glu Ala Glu Glu Asp Arg Gln Pro Gly Pro Pro Leu Gly Ala Pro Asn 
                645                 650                 655     


Pro Ser Ala Ser Gly Pro Pro Glu Asp Arg Asp Leu Glu Glu Glu Leu 
            660                 665                 670         


Pro Gly Glu Glu Leu Ser 
        675             


<210>  37
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FoxP3(P1) forward primer

<400>  37
aaagatagta cgttgtccgc ag                                                22


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: FoxP3(P1) reverse primer

<400>  38
atttgcaccc tgcattgcgc                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL10 forward primer

<400>  39
tctgtgctgc ctcgtgctcc                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: IL10 reverse primer

<400>  40
tctgacagag cctggcaccc                                                   20


<210>  41
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDH forward primer

<400>  41
tccactcacg gcaaattcaa c                                                 21


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic: mGAPDH reverse primer

<400>  42
cgctcctgga agatggtgat g                                                 21


