                         SEQUENCE LISTING

<110>  CADILA HEALTHCARE LIMITED
 
<120>  A vaccine against SARS-CoV-2 and preparation thereof

<130>  PCT0824

<150>  202021017410
<151>  2020-04-23

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  1271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-length S protein

<400>  1

Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
1               5                   10                  15      


Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
            20                  25                  30          


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
        35                  40                  45              


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
    50                  55                  60                  


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
65                  70                  75                  80  


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
                85                  90                  95      


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
            100                 105                 110         


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
        115                 120                 125             


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
    130                 135                 140                 


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
145                 150                 155                 160 


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
                165                 170                 175     


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
            180                 185                 190         


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
        195                 200                 205             


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
    210                 215                 220                 


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
225                 230                 235                 240 


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
                245                 250                 255     


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
            260                 265                 270         


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
        275                 280                 285             


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
    290                 295                 300                 


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
305                 310                 315                 320 


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
                325                 330                 335     


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
            340                 345                 350         


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
        355                 360                 365             


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
    370                 375                 380                 


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
385                 390                 395                 400 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
                405                 410                 415     


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
            420                 425                 430         


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
        435                 440                 445             


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
    450                 455                 460                 


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
465                 470                 475                 480 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
                485                 490                 495     


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
        515                 520                 525             


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
                565                 570                 575     


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
625                 630                 635                 640 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
                645                 650                 655     


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser 
        675                 680                 685             


Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val 
    690                 695                 700                 


Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser 
705                 710                 715                 720 


Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp 
                725                 730                 735     


Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu 
            740                 745                 750         


Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly 
        755                 760                 765             


Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val 
    770                 775                 780                 


Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn 
785                 790                 795                 800 


Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
                805                 810                 815     


Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe 
            820                 825                 830         


Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu 
        835                 840                 845             


Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu 
    850                 855                 860                 


Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr 
865                 870                 875                 880 


Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro 
                885                 890                 895     


Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln 
            900                 905                 910         


Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser 
        915                 920                 925             


Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu 
    930                 935                 940                 


Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr 
945                 950                 955                 960 


Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu 
                965                 970                 975     


Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile 
            980                 985                 990         


Asp Arg Leu Ile Thr Gly Arg Leu  Gln Ser Leu Gln Thr  Tyr Val Thr 
        995                 1000                 1005             


Gln Gln  Leu Ile Arg Ala Ala  Glu Ile Arg Ala Ser  Ala Asn Leu 
    1010                 1015                 1020             


Ala Ala  Thr Lys Met Ser Glu  Cys Val Leu Gly Gln  Ser Lys Arg 
    1025                 1030                 1035             


Val Asp  Phe Cys Gly Lys Gly  Tyr His Leu Met Ser  Phe Pro Gln 
    1040                 1045                 1050             


Ser Ala  Pro His Gly Val Val  Phe Leu His Val Thr  Tyr Val Pro 
    1055                 1060                 1065             


Ala Gln  Glu Lys Asn Phe Thr  Thr Ala Pro Ala Ile  Cys His Asp 
    1070                 1075                 1080             


Gly Lys  Ala His Phe Pro Arg  Glu Gly Val Phe Val  Ser Asn Gly 
    1085                 1090                 1095             


Thr His  Trp Phe Val Thr Gln  Arg Asn Phe Tyr Glu  Pro Gln Ile 
    1100                 1105                 1110             


Ile Thr  Thr Asp Asn Thr Phe  Val Ser Gly Asn Cys  Asp Val Val 
    1115                 1120                 1125             


Ile Gly  Ile Val Asn Asn Thr  Val Tyr Asp Pro Leu  Gln Pro Glu 
    1130                 1135                 1140             


Leu Asp  Ser Phe Lys Glu Glu  Leu Asp Lys Tyr Phe  Lys Asn His 
    1145                 1150                 1155             


Thr Ser  Pro Asp Val Asp Leu  Gly Asp Ile Ser Gly  Ile Asn Ala 
    1160                 1165                 1170             


Ser Val  Val Asn Ile Gln Lys  Glu Ile Asp Arg Leu  Asn Glu Val 
    1175                 1180                 1185             


Ala Lys  Asn Leu Asn Glu Ser  Leu Ile Asp Leu Gln  Glu Leu Gly 
    1190                 1195                 1200             


Lys Tyr  Glu Gln Tyr Ile Lys  Trp Pro Trp Tyr Ile  Trp Leu Gly 
    1205                 1210                 1215             


Phe Ile  Ala Gly Leu Ile Ala  Ile Val Met Val Thr  Ile Met Leu 
    1220                 1225                 1230             


Cys Cys  Met Thr Ser Cys Cys  Ser Cys Leu Lys Gly  Cys Cys Ser 
    1235                 1240                 1245             


Cys Gly  Ser Cys Cys Lys Phe  Asp Glu Asp Asp Ser  Glu Pro Val 
    1250                 1255                 1260             


Leu Lys  Gly Val Lys Leu His  Tyr 
    1265                 1270     


<210>  2
<211>  684
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of S1 region of S protein

<400>  2

Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val Asn 
1               5                   10                  15      


Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr 
            20                  25                  30          


Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His 
        35                  40                  45              


Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe 
    50                  55                  60                  


His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn 
65                  70                  75                  80  


Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys 
                85                  90                  95      


Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys 
            100                 105                 110         


Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys 
        115                 120                 125             


Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr 
    130                 135                 140                 


His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser 
145                 150                 155                 160 


Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met 
                165                 170                 175     


Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val 
            180                 185                 190         


Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro 
        195                 200                 205             


Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro 
    210                 215                 220                 


Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu 
225                 230                 235                 240 


Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly 
                245                 250                 255     


Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg 
            260                 265                 270         


Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val 
        275                 280                 285             


Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser 
    290                 295                 300                 


Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln 
305                 310                 315                 320 


Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro 
                325                 330                 335     


Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp 
            340                 345                 350         


Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr 
        355                 360                 365             


Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr 
    370                 375                 380                 


Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val 
385                 390                 395                 400 


Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys 
                405                 410                 415     


Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
            420                 425                 430         


Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr 
        435                 440                 445             


Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu 
    450                 455                 460                 


Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn 
465                 470                 475                 480 


Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe 
                485                 490                 495     


Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu 
            500                 505                 510         


Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys 
        515                 520                 525             


Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly 
    530                 535                 540                 


Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro 
545                 550                 555                 560 


Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg 
                565                 570                 575     


Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly 
            580                 585                 590         


Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala 
        595                 600                 605             


Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His 
    610                 615                 620                 


Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn 
625                 630                 635                 640 


Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn 
                645                 650                 655     


Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser 
            660                 665                 670         


Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
        675                 680                 


<210>  3
<211>  1289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-length S gene with IgE leader 
       sequence

<400>  3

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
            20                  25                  30          


Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
        35                  40                  45              


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
    50                  55                  60                  


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
65                  70                  75                  80  


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
                85                  90                  95      


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
            100                 105                 110         


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
        115                 120                 125             


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
    130                 135                 140                 


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
145                 150                 155                 160 


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
                165                 170                 175     


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
            180                 185                 190         


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
        195                 200                 205             


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
    210                 215                 220                 


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
                245                 250                 255     


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
            260                 265                 270         


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
        275                 280                 285             


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
    290                 295                 300                 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
305                 310                 315                 320 


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
                325                 330                 335     


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
            340                 345                 350         


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
        355                 360                 365             


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
    370                 375                 380                 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
385                 390                 395                 400 


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
                405                 410                 415     


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
            420                 425                 430         


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
        435                 440                 445             


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
    450                 455                 460                 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
465                 470                 475                 480 


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
                485                 490                 495     


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
            500                 505                 510         


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
        515                 520                 525             


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
    530                 535                 540                 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
545                 550                 555                 560 


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
                565                 570                 575     


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
            580                 585                 590         


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
        595                 600                 605             


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
    610                 615                 620                 


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
625                 630                 635                 640 


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
                645                 650                 655     


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
            660                 665                 670         


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
        675                 680                 685             


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
    690                 695                 700                 


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
705                 710                 715                 720 


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
                725                 730                 735     


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
            740                 745                 750         


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
        755                 760                 765             


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
    770                 775                 780                 


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
785                 790                 795                 800 


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
                805                 810                 815     


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
            820                 825                 830         


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
        835                 840                 845             


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
    850                 855                 860                 


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
                885                 890                 895     


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
            900                 905                 910         


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
        915                 920                 925             


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
    930                 935                 940                 


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
945                 950                 955                 960 


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
                965                 970                 975     


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
            980                 985                 990         


Val Leu Asn Asp Ile Leu Ser Arg  Leu Asp Lys Val Glu  Ala Glu Val 
        995                 1000                 1005             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1010                 1015                 1020             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1025                 1030                 1035             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1040                 1045                 1050             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1055                 1060                 1065             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1070                 1075                 1080             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1085                 1090                 1095             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1100                 1105                 1110             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1115                 1120                 1125             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1130                 1135                 1140             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1145                 1150                 1155             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1160                 1165                 1170             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1175                 1180                 1185             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1190                 1195                 1200             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1205                 1210                 1215             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile 
    1220                 1225                 1230             


Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr 
    1235                 1240                 1245             


Ile Met  Leu Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly 
    1250                 1255                 1260             


Cys Cys  Ser Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser 
    1265                 1270                 1275             


Glu Pro  Val Leu Lys Gly Val  Lys Leu His Tyr 
    1280                 1285                 


<210>  4
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of full-length S gene with IgE leader 
       sequence

<400>  4
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca tagcttcgtc       60

tttctcgtgc tgctgcctct ggtgtccagc cagtgtgtga acctgaccac aagaacacag      120

ctgcctccag cctacaccaa cagctttacc agaggcgtgt actaccccga caaggtgttc      180

agatctagcg tgctgcacag cacccaggac ctgtttctgc ccttcttcag caacgtgacc      240

tggttccacg ccatccatgt gtccggcacc aatggcacca agagattcga caaccccgtg      300

ctgcccttca acgatggggt gtactttgcc agcaccgaga agtccaacat catcagaggc      360

tggatcttcg gcaccacact ggacagcaag acccagagcc tgctgatcgt gaacaacgcc      420

accaacgtgg tcatcaaagt gtgcgagttc cagttctgca acgacccctt cctgggcgtc      480

tactaccaca aaaacaacaa gagctggatg gaaagcgagt tccgggtgta cagcagcgcc      540

aacaactgca ccttcgagta cgtgtcccag cctttcctga tggatctgga aggcaagcag      600

ggcaacttca agaacctgcg cgagttcgtg ttcaagaaca tcgacggcta cttcaagatc      660

tacagcaagc acacccctat caacctcgtg cgggatctgc ctcagggctt ttctgctctg      720

gaacctctgg tggacctgcc tatcggcatc aacatcaccc ggtttcagac cctgctggcc      780

ctgcacagat cttacctgac acctggcgat agcagctctg gatggacagc tggcgccgct      840

gcctattatg tgggctacct gcagcctcgg accttcctgc tgaagtacaa cgagaacggc      900

accatcaccg acgccgtgga ttgtgctctg gatcccctga gcgagacaaa gtgtaccctg      960

aagtccttca ccgtggaaaa gggcatctac cagaccagca acttcagagt gcagcccacc     1020

gagagcatcg tgcggttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1080

gccaccagat ttgccagcgt gtacgcctgg aaccggaaga gaatcagcaa ctgcgtggcc     1140

gactacagcg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtcc     1200

cctaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatcaga     1260

ggcgacgaag ttcggcagat cgctcctgga cagacaggca agatcgccga ttacaactac     1320

aagctgcccg acgacttcac cggctgcgtg atcgcctgga atagcaacaa cctggactcc     1380

aaagtcggcg gcaactacaa ctacctgtac cggctgttcc ggaagtccaa tctgaagccc     1440

ttcgagcggg acatctccac cgaaatctat caggccggca gcaccccttg taacggcgtg     1500

gaaggcttca actgctactt cccactgcag tcctacggct ttcagcctac caatggcgtg     1560

ggctatcagc cctatagagt ggtggtgctg agcttcgaac tgctgcatgc ccctgctacc     1620

gtgtgcggcc ctaagaagtc taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1680

aacggcctga ccggcacagg cgtgctgaca gagagcaaca agaagttcct gcctttccag     1740

cagtttggcc gggatatcgc cgataccaca gacgccgtta gagatcccca gacactggaa     1800

atcctggaca tcaccccatg cagctttggc ggagtgtctg tgatcacccc tggcaccaat     1860

accagcaatc aggtggccgt gctgtatcag gacgtgaact gtacagaggt gccagtggcc     1920

attcacgccg atcagctgac acccacttgg agagtgtact ccaccggctc caacgtgttc     1980

cagactagag ccggatgtct gatcggagcc gagcatgtga acaacagcta cgagtgcgac     2040

atccccatcg gagctggcat ctgtgccagc taccagacac agacaaatag ccccagacgg     2100

gccagaagcg tggcctctca gagcatcatt gcctacacaa tgagcctggg cgccgagaat     2160

tctgtggcct acagcaacaa ctctatcgct atccccacca acttcaccat cagcgtgacc     2220

accgagatcc tgcctgtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2280

ggcgattcca ccgagtgcag caacctgctg ctgcagtacg gcagcttctg cacccagctg     2340

aatagagccc tgacagggat cgccgtggaa caggacaaga atacccaaga ggtgttcgcc     2400

caagtgaagc agatctacaa gacccctcct atcaaggact tcggcggctt caatttcagc     2460

cagattctgc ccgatcctag caagcccagc aagcggagct ttatcgagga cctgctgttc     2520

aacaaagtga cactggccga cgccggcttc atcaagcagt atggcgattg cctgggcgac     2580

attgccgcca gagatctgat ttgcgcccag aagtttaacg gactgacagt gctgcctcct     2640

ctgctgaccg atgagatgat cgcccagtac acatctgctc tgctggccgg cacaatcacc     2700

agcggatgga catttggagc tggcgcagcc ctgcagatcc cctttgctat gcagatggcc     2760

taccggttca acggcatcgg agtgacccag aatgtgctgt acgagaacca gaagctgatc     2820

gccaaccagt tcaacagcgc catcggcaag atccaggata gcctgtctag cacagccagc     2880

gctctgggca aactgcagga cgtggtcaat cagaacgctc aggccctgaa caccctcgtg     2940

aagcagctga gcagcaattt cggcgccatc agctccgtgc tgaacgatat cctgagccgg     3000

ctggataagg tggaagccga ggtgcagatc gacagactga tcacaggcag actgcagagc     3060

ctccagacat acgtgaccca gcagctgatc agagccgccg agattagagc ctctgccaat     3120

ctggccgcca caaagatgtc tgagtgtgtg ctgggccaga gcaagagagt ggatttctgc     3180

ggcaagggct accacctgat gagctttcca cagtctgctc ctcacggcgt ggtgtttctg     3240

catgtgacct acgtgcccgc tcaagagaag aacttcacaa cagcccctgc catctgccac     3300

gacggaaagg cccattttcc tagagaaggc gtgttcgtgt ccaacggcac ccattggttc     3360

gtgacacagc ggaacttcta cgagccccag atcatcacca ccgacaacac cttcgtgtct     3420

ggcaactgtg acgtcgtgat cggcattgtg aacaataccg tgtacgaccc tctgcagccc     3480

gagctggaca gcttcaaaga ggaactggac aagtacttta agaaccacac aagccccgac     3540

gtggacctgg gcgatattag cggcatcaat gccagcgtcg tgaacatcca gaaagagatc     3600

gaccggctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3660

gggaagtacg agcagtacat caagtggccc tggtacatct ggctgggctt tatcgccgga     3720

ctgattgcca tcgtgatggt cacaatcatg ctgtgctgca tgaccagctg ctgtagctgc     3780

ctgaagggct gttgcagctg tggcagctgc tgcaagttcg acgaggatga tagcgagcct     3840

gtgctgaagg gcgtgaaact gcactactaa tga                                  3873


<210>  5
<211>  1293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full length S gene with t-PA leader 
       sequence

<400>  5

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Phe Val Phe Leu Val Leu Leu Pro Leu Val 
            20                  25                  30          


Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
        35                  40                  45              


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
    50                  55                  60                  


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
65                  70                  75                  80  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
                85                  90                  95      


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
            100                 105                 110         


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
        115                 120                 125             


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
    130                 135                 140                 


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
145                 150                 155                 160 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
                165                 170                 175     


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
            180                 185                 190         


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
        195                 200                 205             


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
    210                 215                 220                 


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
225                 230                 235                 240 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
                245                 250                 255     


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
            260                 265                 270         


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
        275                 280                 285             


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
    290                 295                 300                 


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
305                 310                 315                 320 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
                325                 330                 335     


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            340                 345                 350         


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        355                 360                 365             


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    370                 375                 380                 


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
385                 390                 395                 400 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                405                 410                 415     


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            420                 425                 430         


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        435                 440                 445             


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    450                 455                 460                 


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
465                 470                 475                 480 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                485                 490                 495     


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            500                 505                 510         


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        515                 520                 525             


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
    530                 535                 540                 


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
545                 550                 555                 560 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
                565                 570                 575     


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
            580                 585                 590         


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
        595                 600                 605             


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
    610                 615                 620                 


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
                645                 650                 655     


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
            660                 665                 670         


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
        675                 680                 685             


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg 
    690                 695                 700                 


Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu 
705                 710                 715                 720 


Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro 
                725                 730                 735     


Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met 
            740                 745                 750         


Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr 
        755                 760                 765             


Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu 
    770                 775                 780                 


Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln 
785                 790                 795                 800 


Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys 
                805                 810                 815     


Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys 
            820                 825                 830         


Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr 
        835                 840                 845             


Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp 
    850                 855                 860                 


Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr 
865                 870                 875                 880 


Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser 
                885                 890                 895     


Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly 
            900                 905                 910         


Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn 
        915                 920                 925             


Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile 
    930                 935                 940                 


Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser 
945                 950                 955                 960 


Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn 
                965                 970                 975     


Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly 
            980                 985                 990         


Ala Ile Ser Ser Val Leu Asn Asp  Ile Leu Ser Arg Leu  Asp Lys Val 
        995                 1000                 1005             


Glu Ala  Glu Val Gln Ile Asp  Arg Leu Ile Thr Gly  Arg Leu Gln 
    1010                 1015                 1020             


Ser Leu  Gln Thr Tyr Val Thr  Gln Gln Leu Ile Arg  Ala Ala Glu 
    1025                 1030                 1035             


Ile Arg  Ala Ser Ala Asn Leu  Ala Ala Thr Lys Met  Ser Glu Cys 
    1040                 1045                 1050             


Val Leu  Gly Gln Ser Lys Arg  Val Asp Phe Cys Gly  Lys Gly Tyr 
    1055                 1060                 1065             


His Leu  Met Ser Phe Pro Gln  Ser Ala Pro His Gly  Val Val Phe 
    1070                 1075                 1080             


Leu His  Val Thr Tyr Val Pro  Ala Gln Glu Lys Asn  Phe Thr Thr 
    1085                 1090                 1095             


Ala Pro  Ala Ile Cys His Asp  Gly Lys Ala His Phe  Pro Arg Glu 
    1100                 1105                 1110             


Gly Val  Phe Val Ser Asn Gly  Thr His Trp Phe Val  Thr Gln Arg 
    1115                 1120                 1125             


Asn Phe  Tyr Glu Pro Gln Ile  Ile Thr Thr Asp Asn  Thr Phe Val 
    1130                 1135                 1140             


Ser Gly  Asn Cys Asp Val Val  Ile Gly Ile Val Asn  Asn Thr Val 
    1145                 1150                 1155             


Tyr Asp  Pro Leu Gln Pro Glu  Leu Asp Ser Phe Lys  Glu Glu Leu 
    1160                 1165                 1170             


Asp Lys  Tyr Phe Lys Asn His  Thr Ser Pro Asp Val  Asp Leu Gly 
    1175                 1180                 1185             


Asp Ile  Ser Gly Ile Asn Ala  Ser Val Val Asn Ile  Gln Lys Glu 
    1190                 1195                 1200             


Ile Asp  Arg Leu Asn Glu Val  Ala Lys Asn Leu Asn  Glu Ser Leu 
    1205                 1210                 1215             


Ile Asp  Leu Gln Glu Leu Gly  Lys Tyr Glu Gln Tyr  Ile Lys Trp 
    1220                 1225                 1230             


Pro Trp  Tyr Ile Trp Leu Gly  Phe Ile Ala Gly Leu  Ile Ala Ile 
    1235                 1240                 1245             


Val Met  Val Thr Ile Met Leu  Cys Cys Met Thr Ser  Cys Cys Ser 
    1250                 1255                 1260             


Cys Leu  Lys Gly Cys Cys Ser  Cys Gly Ser Cys Cys  Lys Phe Asp 
    1265                 1270                 1275             


Glu Asp  Asp Ser Glu Pro Val  Leu Lys Gly Val Lys  Leu His Tyr 
    1280                 1285                 1290             


<210>  6
<211>  3885
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of full length S gene with t-PA leader 
       sequence

<400>  6
atggatgcta tgaagcgagg actgtgctgc gtgctgctgc tgtgtggtgc agtgttcgtg       60

tcccctttcg tgttcctggt cctgctgcct ctggtgtcca gccagtgtgt gaacctgacc      120

accagaacac agctgcctcc agcctacacc aatagcttca ccaggggcgt gtactacccc      180

gacaaggtgt tcagatctag cgtgctgcac agcacccagg acctgtttct gcccttcttc      240

agcaacgtga cctggttcca cgccatccat gtgtccggca ccaatggcac caagagattc      300

gacaaccccg tgctgccctt caacgatggg gtgtactttg ccagcaccga gaagtccaac      360

atcatcagag gctggatctt cggcaccaca ctggacagca agacccagag cctgctgatc      420

gtgaacaacg ccaccaacgt ggtcatcaaa gtgtgcgagt tccagttctg caacgaccca      480

ttcctgggag tctactacca caagaacaac aagagctgga tggaaagcga gttccgggtg      540

tacagcagcg ccaacaactg caccttcgag tacgtgtccc agcctttcct gatggacctg      600

gaaggcaagc agggcaactt caagaacctg cgcgagttcg tgttcaagaa catcgacggc      660

tacttcaaga tctacagcaa gcacacccct atcaacctcg tgcgggatct gcctcagggc      720

ttttctgctc tggaacctct ggtggacctg cctatcggca tcaacatcac ccggtttcag      780

accctgctgg ccctgcacag atcttacctg acacctggcg atagcagctc tggatggaca      840

gctggcgccg ctgcctatta tgtgggctac ctgcagcctc ggaccttcct gctgaagtac      900

aacgagaacg gcaccatcac cgacgccgtg gattgtgctc tggatcccct gagcgagaca      960

aagtgtaccc tgaagtcctt caccgtggaa aagggcatct accagaccag caacttcaga     1020

gtgcagccca ccgagagcat cgtgcggttc cccaatatca ccaatctgtg ccccttcggc     1080

gaggtgttca atgccacaag atttgccagc gtgtacgcct ggaaccggaa gagaatcagc     1140

aactgcgtgg ccgactacag cgtgctgtac aatagcgcca gcttcagcac cttcaagtgc     1200

tacggcgtgt cacccaccaa gctgaacgac ctgtgcttca ccaatgtgta cgccgacagc     1260

ttcgtgatca gaggcgacga agttcggcag atcgctcctg gacagacagg caagatcgcc     1320

gattacaact acaagctgcc cgacgacttc accggctgcg tgatcgcctg gaatagcaac     1380

aacctggact ccaaagtcgg cggcaactac aactacctgt accggctgtt ccggaagtcc     1440

aatctgaagc ccttcgagcg ggacatctcc accgaaatct atcaggccgg cagcacccct     1500

tgtaacggcg tggaaggctt caactgctac ttcccactgc agtcctacgg ctttcagcct     1560

accaatggcg tgggctatca gccctataga gtggtggtgc tgagcttcga actgctgcat     1620

gcccctgcta ccgtgtgcgg ccctaagaag tctaccaacc tggtcaagaa caaatgcgtg     1680

aacttcaact tcaacggcct gaccggcaca ggcgtgctga cagagagcaa caagaagttc     1740

ctgcctttcc agcagtttgg ccgggatatc gccgatacca cagacgccgt tagagatccc     1800

cagacactgg aaatcctgga catcacccca tgcagctttg gcggcgtgtc cgtgatcaca     1860

cctggcacca ataccagcaa tcaggtggcc gtgctgtatc aggacgtgaa ctgtacagag     1920

gtgccagtgg ccattcacgc cgatcagctg acacccactt ggagagtgta ctccaccggc     1980

tccaacgtgt tccagactag agccggatgt ctgatcggag ccgagcatgt gaacaacagc     2040

tacgagtgcg acatccccat cggagctggc atctgtgcca gctaccagac acagacaaat     2100

agccccagac gggccagaag cgtggcctct cagagcatca ttgcctacac aatgagcctg     2160

ggcgccgaga attctgtggc ctacagcaac aactctatcg ctatccccac caacttcacc     2220

atcagcgtga ccaccgagat cctgcctgtg tccatgacca agaccagcgt ggactgcacc     2280

atgtacatct gcggcgattc caccgagtgc agcaacctgc tgctgcagta cggcagcttc     2340

tgcacccagc tgaatagagc cctgacaggg atcgccgtgg aacaggacaa gaacacccaa     2400

gaggtgttcg cccaagtgaa gcagatctac aagacccctc ctatcaagga cttcggcggc     2460

ttcaatttca gccagattct gcccgatcct agcaagccca gcaagcggag ctttatcgag     2520

gacctgctgt tcaacaaagt gacactggcc gacgccggct tcatcaagca gtatggcgat     2580

tgcctgggcg acattgccgc cagagatctg atttgcgccc agaagtttaa cggactgaca     2640

gtgctgcctc ctctgctgac cgatgagatg atcgcccagt acacatctgc tctgctggcc     2700

ggcacaatca ccagcggatg gacatttgga gctggcgcag ccctgcagat cccctttgct     2760

atgcagatgg cctaccggtt caacggcatc ggagtgaccc agaatgtgct gtacgagaac     2820

cagaagctga tcgccaacca gttcaacagc gccatcggca agatccagga tagcctgtct     2880

agcacagcca gcgctctggg caaactgcag gacgtggtca atcagaacgc tcaggccctg     2940

aacaccctcg tgaagcagct gagcagcaat ttcggcgcca tcagctccgt gctgaacgat     3000

atcctgagcc ggctggataa ggtggaagcc gaggtgcaga tcgacagact gatcacaggc     3060

agactgcaga gcctccagac atacgtgacc cagcagctga tcagagccgc cgagattaga     3120

gcctctgcca atctggccgc cacaaagatg tctgagtgtg tgctgggcca gagcaagaga     3180

gtggatttct gcggcaaggg ctaccacctg atgagctttc cacagtctgc tcctcacggc     3240

gtggtgtttc tgcatgtgac ctacgtgccc gctcaagaga agaacttcac aacagcccct     3300

gccatctgcc acgacggaaa ggcccatttt cctagagaag gcgtgttcgt cagcaacggc     3360

acccattggt tcgtgacaca gcggaacttc tacgagcccc agatcatcac caccgacaac     3420

accttcgtgt ctggcaactg tgacgtcgtg atcggcattg tgaacaatac cgtgtacgac     3480

cctctgcagc ccgagctgga cagcttcaaa gaggaactgg acaagtactt taagaaccac     3540

acaagccccg acgtggacct gggcgatatt agcggcatca atgccagcgt cgtgaacatc     3600

cagaaagaga tcgaccggct gaacgaggtg gccaagaatc tgaacgagag cctgatcgac     3660

ctgcaagaac tggggaagta cgagcagtac atcaagtggc cctggtacat ctggctgggc     3720

tttatcgccg gactgattgc catcgtgatg gtcacaatca tgctgtgctg catgaccagc     3780

tgctgtagct gcctgaaggg ctgttgcagc tgtggcagct gctgcaagtt cgacgaggat     3840

gatagcgagc ctgtgctgaa gggcgtgaaa ctgcactact aatga                     3885


<210>  7
<211>  702
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of S1 region of S gene with IgE leader 
       sequence

<400>  7

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
            20                  25                  30          


Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
        35                  40                  45              


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
    50                  55                  60                  


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
65                  70                  75                  80  


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
                85                  90                  95      


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
            100                 105                 110         


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
        115                 120                 125             


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
    130                 135                 140                 


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
145                 150                 155                 160 


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
                165                 170                 175     


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
            180                 185                 190         


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
        195                 200                 205             


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
    210                 215                 220                 


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
                245                 250                 255     


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
            260                 265                 270         


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
        275                 280                 285             


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
    290                 295                 300                 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
305                 310                 315                 320 


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
                325                 330                 335     


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
            340                 345                 350         


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
        355                 360                 365             


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
    370                 375                 380                 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
385                 390                 395                 400 


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
                405                 410                 415     


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
            420                 425                 430         


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
        435                 440                 445             


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
    450                 455                 460                 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
465                 470                 475                 480 


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
                485                 490                 495     


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
            500                 505                 510         


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
        515                 520                 525             


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
    530                 535                 540                 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
545                 550                 555                 560 


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
                565                 570                 575     


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
            580                 585                 590         


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
        595                 600                 605             


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
    610                 615                 620                 


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
625                 630                 635                 640 


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
                645                 650                 655     


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
            660                 665                 670         


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
        675                 680                 685             


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg 
    690                 695                 700         


<210>  8
<211>  2112
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of S1 region of S gene with IgE leader 
       sequence

<400>  8
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca tagcttcgtc       60

tttctcgtgc tgctgcctct ggtgtccagc cagtgtgtga acctgaccac aagaacacag      120

ctgcctccag cctacaccaa cagctttacc agaggcgtgt actaccccga caaggtgttc      180

agatctagcg tgctgcacag cacccaggac ctgtttctgc ccttcttcag caacgtgacc      240

tggttccacg ccatccatgt gtccggcacc aatggcacca agagattcga caaccccgtg      300

ctgcccttca acgatggggt gtactttgcc agcaccgaga agtccaacat catcagaggc      360

tggatcttcg gcaccacact ggacagcaag acccagagcc tgctgatcgt gaacaacgcc      420

accaacgtgg tcatcaaagt gtgcgagttc cagttctgca acgacccctt cctgggcgtc      480

tactaccaca aaaacaacaa gagctggatg gaaagcgagt tccgggtgta cagcagcgcc      540

aacaactgca ccttcgagta cgtgtcccag cctttcctga tggatctgga aggcaagcag      600

ggcaacttca agaacctgcg cgagttcgtg ttcaagaaca tcgacggcta cttcaagatc      660

tacagcaagc acacccctat caacctcgtg cgggatctgc ctcagggctt ttctgctctg      720

gaacctctgg tggacctgcc tatcggcatc aacatcaccc ggtttcagac cctgctggcc      780

ctgcacagat cttacctgac acctggcgat agcagctctg gatggacagc tggcgccgct      840

gcctattatg tgggctacct gcagcctcgg accttcctgc tgaagtacaa cgagaacggc      900

accatcaccg acgccgtgga ttgtgctctg gatcccctga gcgagacaaa gtgtaccctg      960

aagtccttca ccgtggaaaa gggcatctac cagaccagca acttcagagt gcagcccacc     1020

gagagcatcg tgcggttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1080

gccaccagat ttgccagcgt gtacgcctgg aaccggaaga gaatcagcaa ctgcgtggcc     1140

gactacagcg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtcc     1200

cctaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatcaga     1260

ggcgacgaag ttcggcagat cgctcctgga cagacaggca agatcgccga ttacaactac     1320

aagctgcccg acgacttcac cggctgcgtg atcgcctgga atagcaacaa cctggactcc     1380

aaagtcggcg gcaactacaa ctacctgtac cggctgttcc ggaagtccaa tctgaagccc     1440

ttcgagcggg acatctccac cgaaatctat caggccggca gcaccccttg taacggcgtg     1500

gaaggcttca actgctactt cccactgcag tcctacggct ttcagcctac caatggcgtg     1560

ggctatcagc cctatagagt ggtggtgctg agcttcgaac tgctgcatgc ccctgctacc     1620

gtgtgcggcc ctaagaagtc taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1680

aacggcctga ccggcacagg cgtgctgaca gagagcaaca agaagttcct gcctttccag     1740

cagtttggcc gggatatcgc cgataccaca gacgccgtta gagatcccca gacactggaa     1800

atcctggaca tcaccccatg cagctttggc ggagtgtctg tgatcacccc tggcaccaat     1860

accagcaatc aggtggccgt gctgtatcag gacgtgaact gtacagaggt gccagtggcc     1920

attcacgccg atcagctgac acccacttgg agagtgtact ccaccggctc caacgtgttc     1980

cagactagag ccggatgtct gatcggagcc gagcatgtga acaacagcta cgagtgcgac     2040

atccccatcg gagctggcat ctgtgccagc taccagacac agacaaacag ccccagacgg     2100

gccagataat ga                                                         2112


<210>  9
<211>  706
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of S1 region of S gene with t-PA leader 
       sequence

<400>  9

Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      


Ala Val Phe Val Ser Pro Phe Val Phe Leu Val Leu Leu Pro Leu Val 
            20                  25                  30          


Ser Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala 
        35                  40                  45              


Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe 
    50                  55                  60                  


Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe 
65                  70                  75                  80  


Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly 
                85                  90                  95      


Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr 
            100                 105                 110         


Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly 
        115                 120                 125             


Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala 
    130                 135                 140                 


Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro 
145                 150                 155                 160 


Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser 
                165                 170                 175     


Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val 
            180                 185                 190         


Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys 
        195                 200                 205             


Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile 
    210                 215                 220                 


Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly 
225                 230                 235                 240 


Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile 
                245                 250                 255     


Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro 
            260                 265                 270         


Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val 
        275                 280                 285             


Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly 
    290                 295                 300                 


Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr 
305                 310                 315                 320 


Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
                325                 330                 335     


Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn 
            340                 345                 350         


Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe 
        355                 360                 365             


Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala 
    370                 375                 380                 


Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys 
385                 390                 395                 400 


Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val 
                405                 410                 415     


Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala 
            420                 425                 430         


Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp 
        435                 440                 445             


Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser 
    450                 455                 460                 


Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser 
465                 470                 475                 480 


Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala 
                485                 490                 495     


Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro 
            500                 505                 510         


Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro 
        515                 520                 525             


Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr 
    530                 535                 540                 


Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
545                 550                 555                 560 


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
                565                 570                 575     


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
            580                 585                 590         


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
        595                 600                 605             


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
    610                 615                 620                 


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
625                 630                 635                 640 


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
                645                 650                 655     


Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile 
            660                 665                 670         


Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly 
        675                 680                 685             


Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg 
    690                 695                 700                 


Ala Arg 
705     


<210>  10
<211>  2124
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of S1 region of S gene with t-PA leader 
       sequence

<400>  10
atggatgcta tgaagcgagg actgtgctgc gtgctgctgc tgtgtggtgc agtgttcgtg       60

tcccctttcg tgttcctggt cctgctgcct ctggtgtcca gccagtgtgt gaacctgacc      120

accagaacac agctgcctcc agcctacacc aatagcttca ccaggggcgt gtactacccc      180

gacaaggtgt tcagatctag cgtgctgcac agcacccagg acctgtttct gcccttcttc      240

agcaacgtga cctggttcca cgccatccat gtgtccggca ccaatggcac caagagattc      300

gacaaccccg tgctgccctt caacgatggg gtgtactttg ccagcaccga gaagtccaac      360

atcatcagag gctggatctt cggcaccaca ctggacagca agacccagag cctgctgatc      420

gtgaacaacg ccaccaacgt ggtcatcaaa gtgtgcgagt tccagttctg caacgaccca      480

ttcctgggag tctactacca caagaacaac aagagctgga tggaaagcga gttccgggtg      540

tacagcagcg ccaacaactg caccttcgag tacgtgtccc agcctttcct gatggacctg      600

gaaggcaagc agggcaactt caagaacctg cgcgagttcg tgttcaagaa catcgacggc      660

tacttcaaga tctacagcaa gcacacccct atcaacctcg tgcgggatct gcctcagggc      720

ttttctgctc tggaacctct ggtggacctg cctatcggca tcaacatcac ccggtttcag      780

accctgctgg ccctgcacag atcttacctg acacctggcg atagcagctc tggatggaca      840

gctggcgccg ctgcctatta tgtgggctac ctgcagcctc ggaccttcct gctgaagtac      900

aacgagaacg gcaccatcac cgacgccgtg gattgtgctc tggatcccct gagcgagaca      960

aagtgtaccc tgaagtcctt caccgtggaa aagggcatct accagaccag caacttcaga     1020

gtgcagccca ccgagagcat cgtgcggttc cccaatatca ccaatctgtg ccccttcggc     1080

gaggtgttca atgccacaag atttgccagc gtgtacgcct ggaaccggaa gagaatcagc     1140

aactgcgtgg ccgactacag cgtgctgtac aatagcgcca gcttcagcac cttcaagtgc     1200

tacggcgtgt cacccaccaa gctgaacgac ctgtgcttca ccaatgtgta cgccgacagc     1260

ttcgtgatca gaggcgacga agttcggcag atcgctcctg gacagacagg caagatcgcc     1320

gattacaact acaagctgcc cgacgacttc accggctgcg tgatcgcctg gaatagcaac     1380

aacctggact ccaaagtcgg cggcaactac aactacctgt accggctgtt ccggaagtcc     1440

aatctgaagc ccttcgagcg ggacatctcc accgaaatct atcaggccgg cagcacccct     1500

tgtaacggcg tggaaggctt caactgctac ttcccactgc agtcctacgg ctttcagcct     1560

accaatggcg tgggctatca gccctataga gtggtggtgc tgagcttcga actgctgcat     1620

gcccctgcta ccgtgtgcgg ccctaagaag tctaccaacc tggtcaagaa caaatgcgtg     1680

aacttcaact tcaacggcct gaccggcaca ggcgtgctga cagagagcaa caagaagttc     1740

ctgcctttcc agcagtttgg ccgggatatc gccgatacca cagacgccgt tagagatccc     1800

cagacactgg aaatcctgga catcacccca tgcagctttg gcggcgtgtc cgtgatcaca     1860

cctggcacca ataccagcaa tcaggtggcc gtgctgtatc aggacgtgaa ctgtacagag     1920

gtgccagtgg ccattcacgc cgatcagctg acacccactt ggagagtgta ctccaccggc     1980

tccaacgtgt tccagactag agccggatgt ctgatcggag ccgagcatgt gaacaacagc     2040

tacgagtgcg acatccccat cggagctggc atctgtgcca gctaccagac acagacaaac     2100

agccccagac gggccagata atga                                            2124


<210>  11
<211>  1289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-length S gene (Hexapro) with IgE 
       leader sequence

<400>  11

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
            20                  25                  30          


Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
        35                  40                  45              


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
    50                  55                  60                  


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
65                  70                  75                  80  


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
                85                  90                  95      


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
            100                 105                 110         


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
        115                 120                 125             


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
    130                 135                 140                 


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
145                 150                 155                 160 


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
                165                 170                 175     


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
            180                 185                 190         


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
        195                 200                 205             


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
    210                 215                 220                 


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
                245                 250                 255     


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
            260                 265                 270         


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
        275                 280                 285             


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
    290                 295                 300                 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
305                 310                 315                 320 


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
                325                 330                 335     


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
            340                 345                 350         


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
        355                 360                 365             


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
    370                 375                 380                 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
385                 390                 395                 400 


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
                405                 410                 415     


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
            420                 425                 430         


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
        435                 440                 445             


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
    450                 455                 460                 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
465                 470                 475                 480 


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
                485                 490                 495     


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
            500                 505                 510         


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
        515                 520                 525             


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
    530                 535                 540                 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
545                 550                 555                 560 


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
                565                 570                 575     


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
            580                 585                 590         


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
        595                 600                 605             


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
    610                 615                 620                 


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
625                 630                 635                 640 


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
                645                 650                 655     


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
            660                 665                 670         


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
        675                 680                 685             


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
    690                 695                 700                 


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
705                 710                 715                 720 


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
                725                 730                 735     


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
            740                 745                 750         


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
        755                 760                 765             


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
    770                 775                 780                 


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
785                 790                 795                 800 


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
                805                 810                 815     


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
            820                 825                 830         


Ser Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
        835                 840                 845             


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
    850                 855                 860                 


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
                885                 890                 895     


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln 
            900                 905                 910         


Ile Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
        915                 920                 925             


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
    930                 935                 940                 


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser 
945                 950                 955                 960 


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
                965                 970                 975     


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
            980                 985                 990         


Val Leu Asn Asp Ile Leu Ser Arg  Leu Asp Pro Pro Glu  Ala Glu Val 
        995                 1000                 1005             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1010                 1015                 1020             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1025                 1030                 1035             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1040                 1045                 1050             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1055                 1060                 1065             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1070                 1075                 1080             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1085                 1090                 1095             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1100                 1105                 1110             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1115                 1120                 1125             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1130                 1135                 1140             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1145                 1150                 1155             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1160                 1165                 1170             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1175                 1180                 1185             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1190                 1195                 1200             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1205                 1210                 1215             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile 
    1220                 1225                 1230             


Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr 
    1235                 1240                 1245             


Ile Met  Leu Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly 
    1250                 1255                 1260             


Cys Cys  Ser Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser 
    1265                 1270                 1275             


Glu Pro  Val Leu Lys Gly Val  Lys Leu His Tyr 
    1280                 1285                 


<210>  12
<211>  3873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Nucleotide sequence of full-length S gene (Hexapro) with IgE 
       leader sequence

<400>  12
atggattgga cctggattct gtttctggtg gccgctgcca caagagtgca cagctttgtc       60

tttctcgtgc tgctgcctct ggtgtccagc cagtgtgtga acctgaccac aagaacacag      120

ctgcctccag cctacaccaa cagctttacc agaggcgtgt actaccccga caaggtgttc      180

agatctagcg tgctgcacag cacccaggac ctgtttctgc ccttcttcag caacgtgacc      240

tggttccacg ccatccacgt gtccggcacc aatggcacca agagattcga caaccccgtg      300

ctgcccttca acgatggggt gtactttgcc agcaccgaga agtccaacat catcagaggc      360

tggatcttcg gcaccacact ggacagcaag acccagagcc tgctgatcgt gaacaacgcc      420

accaacgtgg tcatcaaagt gtgcgagttc cagttctgca acgacccctt cctgggcgtc      480

tactaccaca aaaacaacaa gagctggatg gaaagcgagt tccgggtgta cagcagcgcc      540

aacaactgca ccttcgagta cgtgtcccag cctttcctga tggatctgga aggcaagcag      600

ggcaacttca agaacctgcg cgagttcgtg ttcaagaaca tcgacggcta cttcaagatc      660

tacagcaagc acacccctat caacctcgtg cgggatctgc ctcagggctt ttctgctctg      720

gaacctctgg tggacctgcc tatcggcatc aacatcaccc ggtttcagac cctgctggcc      780

ctgcacagat cttacctgac acctggcgat agcagctctg gatggacagc tggcgccgct      840

gcctattatg tgggctacct gcagcctcgg accttcctgc tgaagtacaa cgagaacggc      900

accatcaccg acgccgtgga ttgtgctctg gatcccctga gcgagacaaa gtgcaccctg      960

aagtccttca ccgtggaaaa gggcatctac cagaccagca acttcagagt gcagcccacc     1020

gagagcatcg tgcggttccc caatatcacc aatctgtgcc ccttcggcga ggtgttcaat     1080

gccaccagat ttgccagcgt gtacgcctgg aaccggaaga gaatcagcaa ctgcgtggcc     1140

gactacagcg tgctgtacaa tagcgccagc ttcagcacct tcaagtgcta cggcgtgtcc     1200

cctaccaagc tgaacgacct gtgcttcacc aatgtgtacg ccgacagctt cgtgatcaga     1260

ggcgacgaag ttcggcagat cgctcctgga cagacaggca agatcgccga ttacaactac     1320

aagctgcccg acgacttcac cggctgcgtg atcgcctgga atagcaacaa cctggactcc     1380

aaagtcggcg gcaactacaa ctacctgtac cggctgttcc ggaagtccaa tctgaagccc     1440

ttcgagcggg acatctccac cgaaatctat caggccggca gcaccccttg taacggcgtg     1500

gaaggcttca actgctactt cccactgcag tcctacggct ttcagcctac caatggcgtg     1560

ggctatcagc cctatagagt ggtggtgctg agcttcgaac tgctgcatgc ccctgctacc     1620

gtgtgcggcc ctaagaagtc taccaacctg gtcaagaaca aatgcgtgaa cttcaacttc     1680

aacggcctga ccggcacagg cgtgctgaca gagagcaaca agaagttcct gcctttccag     1740

cagtttggcc gggatatcgc cgataccaca gacgccgtta gagatcccca gacactggaa     1800

atcctggaca tcaccccatg cagctttggc ggagtgtctg tgatcacccc tggcaccaat     1860

accagcaatc aggtggccgt gctgtatcag gacgtgaact gtacagaggt gcccgtggcc     1920

attcacgccg atcaactgac acccacttgg agagtgtact ccaccggctc caacgtgttc     1980

cagactagag ccggatgtct gatcggagcc gagcacgtga acaatagcta cgagtgcgac     2040

atccccatcg gcgctggcat ctgtgccagc taccagacac agacaaatag ccccagacgg     2100

gccagaagcg tggcctctca gagcatcatt gcctacacaa tgagcctggg cgccgagaat     2160

tctgtggcct acagcaacaa ctctatcgct atccccacca acttcaccat cagcgtgacc     2220

accgagatcc tgcctgtgtc catgaccaag accagcgtgg actgcaccat gtacatctgc     2280

ggcgattcca ccgagtgcag caacctgctg ctgcagtacg gcagcttctg cacccagctg     2340

aatagagccc tgacagggat cgccgtggaa caggacaaga atacccaaga ggtgttcgcc     2400

caagtgaagc agatctacaa gacccctcct atcaaggact tcggcggctt caatttcagc     2460

cagattctgc ccgatcctag caagcccagc aagagaagcc caatcgagga cctgctgttc     2520

aacaaagtga cactggccga cgccggcttc atcaagcagt atggcgattg cctgggcgac     2580

attgccgcca gagatctgat ttgcgcccag aagtttaacg gactgacagt gctgcctcct     2640

ctgctgaccg atgagatgat cgcccagtac acatctgctc tgctggccgg cacaatcacc     2700

agcggatgga catttggagc aggcccagct ctgcagatcc catttccaat gcagatggcc     2760

taccggttca acggcatcgg agtgacccag aatgtgctgt acgagaacca gaagctgatc     2820

gccaaccagt tcaacagcgc catcggcaag atccaggaca gcctgtctag cacacctagc     2880

gctctgggca agctgcagga cgtggtcaat cagaacgctc aggccctgaa caccctcgtg     2940

aagcagctga gcagcaattt cggcgccatc agctccgtgc tgaacgatat cctgagcaga     3000

ctggatcctc cagaggccga ggtgcagatc gatagactga tcacaggccg gctgcagtcc     3060

ctgcagacat atgtgacaca gcagctgatc agagccgccg agattagagc ctctgccaat     3120

ctggccgcca caaagatgtc tgagtgtgtg ctgggccaga gcaagagagt ggatttctgc     3180

ggcaagggct accacctgat gagctttcca cagtctgccc ctcacggcgt ggtgtttctg     3240

catgtgacat acgtgcccgc tcaagagaag aacttcacaa cagcccctgc catctgccac     3300

gacggaaagg cccattttcc tagagaaggc gtgttcgtgt ccaacggcac ccattggttc     3360

gtgacccagc ggaacttcta cgagccccag atcatcacca ccgacaacac cttcgtgtct     3420

ggcaactgtg acgtcgtgat cggcattgtg aacaacaccg tgtacgaccc tctgcagccc     3480

gagctggaca gcttcaaaga ggaactggac aagtacttta agaaccacac aagccccgac     3540

gtggacctgg gcgatattag cggcatcaat gcctccgtgg tcaacatcca gaaagagatc     3600

gaccggctga acgaggtggc caagaatctg aacgagagcc tgatcgacct gcaagaactg     3660

gggaagtacg agcagtacat caagtggccc tggtacatct ggctgggctt tatcgccgga     3720

ctgattgcca tcgtgatggt cacaatcatg ctgtgctgca tgaccagctg ttgcagctgc     3780

ctgaagggct gctgtagctg tggctcctgc tgcaagttcg acgaggatga tagcgagcct     3840

gtgctgaagg gcgtgaaact gcactactaa tga                                  3873


<210>  13
<211>  1289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of full-length S gene (2P) with IgE leader 
       sequence

<400>  13

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys 
            20                  25                  30          


Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser 
        35                  40                  45              


Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val 
    50                  55                  60                  


Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr 
65                  70                  75                  80  


Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe 
                85                  90                  95      


Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr 
            100                 105                 110         


Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp 
        115                 120                 125             


Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val 
    130                 135                 140                 


Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val 
145                 150                 155                 160 


Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val 
                165                 170                 175     


Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe 
            180                 185                 190         


Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu 
        195                 200                 205             


Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His 
    210                 215                 220                 


Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu 
225                 230                 235                 240 


Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln 
                245                 250                 255     


Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser 
            260                 265                 270         


Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln 
        275                 280                 285             


Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp 
    290                 295                 300                 


Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu 
305                 310                 315                 320 


Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg 
                325                 330                 335     


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
            340                 345                 350         


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
        355                 360                 365             


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
    370                 375                 380                 


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
385                 390                 395                 400 


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
                405                 410                 415     


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
            420                 425                 430         


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
        435                 440                 445             


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
    450                 455                 460                 


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
465                 470                 475                 480 


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
                485                 490                 495     


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
            500                 505                 510         


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val 
        515                 520                 525             


Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro 
    530                 535                 540                 


Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe 
545                 550                 555                 560 


Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe 
                565                 570                 575     


Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala 
            580                 585                 590         


Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser 
        595                 600                 605             


Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln 
    610                 615                 620                 


Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala 
625                 630                 635                 640 


Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly 
                645                 650                 655     


Ser Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His 
            660                 665                 670         


Val Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys 
        675                 680                 685             


Ala Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val 
    690                 695                 700                 


Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn 
705                 710                 715                 720 


Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr 
                725                 730                 735     


Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser 
            740                 745                 750         


Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn 
        755                 760                 765             


Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu 
    770                 775                 780                 


Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala 
785                 790                 795                 800 


Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly 
                805                 810                 815     


Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg 
            820                 825                 830         


Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala 
        835                 840                 845             


Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg 
    850                 855                 860                 


Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro 
865                 870                 875                 880 


Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala 
                885                 890                 895     


Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln 
            900                 905                 910         


Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val 
        915                 920                 925             


Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe 
    930                 935                 940                 


Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser 
945                 950                 955                 960 


Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu 
                965                 970                 975     


Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser 
            980                 985                 990         


Val Leu Asn Asp Ile Leu Ser Arg  Leu Asp Pro Pro Glu  Ala Glu Val 
        995                 1000                 1005             


Gln Ile  Asp Arg Leu Ile Thr  Gly Arg Leu Gln Ser  Leu Gln Thr 
    1010                 1015                 1020             


Tyr Val  Thr Gln Gln Leu Ile  Arg Ala Ala Glu Ile  Arg Ala Ser 
    1025                 1030                 1035             


Ala Asn  Leu Ala Ala Thr Lys  Met Ser Glu Cys Val  Leu Gly Gln 
    1040                 1045                 1050             


Ser Lys  Arg Val Asp Phe Cys  Gly Lys Gly Tyr His  Leu Met Ser 
    1055                 1060                 1065             


Phe Pro  Gln Ser Ala Pro His  Gly Val Val Phe Leu  His Val Thr 
    1070                 1075                 1080             


Tyr Val  Pro Ala Gln Glu Lys  Asn Phe Thr Thr Ala  Pro Ala Ile 
    1085                 1090                 1095             


Cys His  Asp Gly Lys Ala His  Phe Pro Arg Glu Gly  Val Phe Val 
    1100                 1105                 1110             


Ser Asn  Gly Thr His Trp Phe  Val Thr Gln Arg Asn  Phe Tyr Glu 
    1115                 1120                 1125             


Pro Gln  Ile Ile Thr Thr Asp  Asn Thr Phe Val Ser  Gly Asn Cys 
    1130                 1135                 1140             


Asp Val  Val Ile Gly Ile Val  Asn Asn Thr Val Tyr  Asp Pro Leu 
    1145                 1150                 1155             


Gln Pro  Glu Leu Asp Ser Phe  Lys Glu Glu Leu Asp  Lys Tyr Phe 
    1160                 1165                 1170             


Lys Asn  His Thr Ser Pro Asp  Val Asp Leu Gly Asp  Ile Ser Gly 
    1175                 1180                 1185             


Ile Asn  Ala Ser Val Val Asn  Ile Gln Lys Glu Ile  Asp Arg Leu 
    1190                 1195                 1200             


Asn Glu  Val Ala Lys Asn Leu  Asn Glu Ser Leu Ile  Asp Leu Gln 
    1205                 1210                 1215             


Glu Leu  Gly Lys Tyr Glu Gln  Tyr Ile Lys Trp Pro  Trp Tyr Ile 
    1220                 1225                 1230             


Trp Leu  Gly Phe Ile Ala Gly  Leu Ile Ala Ile Val  Met Val Thr 
    1235                 1240                 1245             


Ile Met  Leu Cys Cys Met Thr  Ser Cys Cys Ser Cys  Leu Lys Gly 
    1250                 1255                 1260             


Cys Cys  Ser Cys Gly Ser Cys  Cys Lys Phe Asp Glu  Asp Asp Ser 
    1265                 1270                 1275             


Glu Pro  Val Leu Lys Gly Val  Lys Leu His Tyr 
    1280                 1285                 


