                         SEQUENCE LISTING

<110>  Cellbio
       Ilyine, Hugh
 
<120>  Tool Improvement

<130>  PG449446WO

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  805
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  2
<211>  223
<212>  PRT
<213>  Homo sapiens

<400>  2

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  3
<211>  3339
<212>  DNA
<213>  Homo sapiens

<400>  3
agtctaggga aagtcattca gtggatgtga tcttggctca caggggacga tgtcaagctc       60

ttcctggctc cttctcagcc ttgttgctgt aactgctgct cagtccacca ttgaggaaca      120

ggccaagaca tttttggaca agtttaacca cgaagccgaa gacctgttct atcaaagttc      180

acttgcttct tggaattata acaccaatat tactgaagag aatgtccaaa acatgaataa      240

tgctggggac aaatggtctg cctttttaaa ggaacagtcc acacttgccc aaatgtatcc      300

actacaagaa attcagaatc tcacagtcaa gcttcagctg caggctcttc agcaaaatgg      360

gtcttcagtg ctctcagaag acaagagcaa acggttgaac acaattctaa atacaatgag      420

caccatctac agtactggaa aagtttgtaa cccagataat ccacaagaat gcttattact      480

tgaaccaggt ttgaatgaaa taatggcaaa cagtttagac tacaatgaga ggctctgggc      540

ttgggaaagc tggagatctg aggtcggcaa gcagctgagg ccattatatg aagagtatgt      600

ggtcttgaaa aatgagatgg caagagcaaa tcattatgag gactatgggg attattggag      660

aggagactat gaagtaaatg gggtagatgg ctatgactac agccgcggcc agttgattga      720

agatgtggaa catacctttg aagagattaa accattatat gaacatcttc atgcctatgt      780

gagggcaaag ttgatgaatg cctatccttc ctatatcagt ccaattggat gcctccctgc      840

tcatttgctt ggtgatatgt ggggtagatt ttggacaaat ctgtactctt tgacagttcc      900

ctttggacag aaaccaaaca tagatgttac tgatgcaatg gtggaccagg cctgggatgc      960

acagagaata ttcaaggagg ccgagaagtt ctttgtatct gttggtcttc ctaatatgac     1020

tcaaggattc tgggaaaatt ccatgctaac ggacccagga aatgttcaga aagcagtctg     1080

ccatcccaca gcttgggacc tggggaaggg cgacttcagg atccttatgt gcacaaaggt     1140

gacaatggac gacttcctga cagctcatca tgagatgggg catatccagt atgatatggc     1200

atatgctgca caaccttttc tgctaagaaa tggagctaat gaaggattcc atgaagctgt     1260

tggggaaatc atgtcacttt ctgcagccac acctaagcat ttaaaatcca ttggtcttct     1320

gtcacccgat tttcaagaag acaatgaaac agaaataaac ttcctgctca aacaagcact     1380

cacgattgtt gggactctgc catttactta catgttagag aagtggaggt ggatggtctt     1440

taaaggggaa attcccaaag accagtggat gaaaaagtgg tgggagatga agcgagagat     1500

agttggggtg gtggaacctg tgccccatga tgaaacatac tgtgaccccg catctctgtt     1560

ccatgtttct aatgattact cattcattcg atattacaca aggacccttt accaattcca     1620

gtttcaagaa gcactttgtc aagcagctaa acatgaaggc cctctgcaca aatgtgacat     1680

ctcaaactct acagaagctg gacagaaact gttcaatatg ctgaggcttg gaaaatcaga     1740

accctggacc ctagcattgg aaaatgttgt aggagcaaag aacatgaatg taaggccact     1800

gctcaactac tttgagccct tatttacctg gctgaaagac cagaacaaga attcttttgt     1860

gggatggagt accgactgga gtccatatgc agaccaaagc atcaaagtga ggataagcct     1920

aaaatcagct cttggagata aagcatatga atggaacgac aatgaaatgt acctgttccg     1980

atcatctgtt gcatatgcta tgaggcagta ctttttaaaa gtaaaaaatc agatgattct     2040

ttttggggag gaggatgtgc gagtggctaa tttgaaacca agaatctcct ttaatttctt     2100

tgtcactgca cctaaaaatg tgtctgatat cattcctaga actgaagttg aaaaggccat     2160

caggatgtcc cggagccgta tcaatgatgc tttccgtctg aatgacaaca gcctagagtt     2220

tctggggata cagccaacac ttggacctcc taaccagccc cctgtttcca tatggctgat     2280

tgtttttgga gttgtgatgg gagtgatagt ggttggcatt gtcatcctga tcttcactgg     2340

gatcagagat cggaagaaga aaaataaagc aagaagtgga gaaaatcctt atgcctccat     2400

cgatattagc aaaggagaaa ataatccagg attccaaaac actgatgatg ttcagacctc     2460

cttttagaaa aatctatgtt tttcctcttg aggtgatttt gttgtatgta aatgttaatt     2520

tcatggtata gaaaatataa gatgataaag atatcattaa atgtcaaaac tatgactctg     2580

ttcagaaaaa aaattgtcca aagacaacat ggccaaggag agagcatctt cattgacatt     2640

gctttcagta tttatttctg tctctggatt tgacttctgt tctgtttctt aataaggatt     2700

ttgtattaga gtatattagg gaaagtgtgt atttggtctc acaggctgtt cagggataat     2760

ctaaatgtaa atgtctgttg aatttctgaa gttgaaaaca aggatatatc attggagcaa     2820

gtgttggatc ttgtatggaa tatggatgga tcacttgtaa ggacagtgcc tgggaactgg     2880

tgtagctgca aggattgaga atggcatgca ttagctcact ttcatttaat ccattgtcaa     2940

ggatgacatg ctttcttcac agtaactcag ttcaagtact atggtgattt gcctacagtg     3000

atgtttggaa tcgatcatgc tttcttcaag gtgacaggtc taaagagaga agaatccagg     3060

gaacaggtag aggacattgc tttttcactt ccaaggtgct tgatcaacat ctccctgaca     3120

acacaaaact agagccaggg gcctccgtga actcccagag catgcctgat agaaactcat     3180

ttctactgtt ctctaactgt ggagtgaatg gaaattccaa ctgtatgttc accctctgaa     3240

gtgggtaccc agtctcttaa atcttttgta tttgctcaca gtgtttgagc agtgctgagc     3300

acaaagcaga cactcaataa atgctagatt tacacactc                            3339


<210>  4
<211>  805
<212>  PRT
<213>  Felis silvestris

<400>  4

Met Ser Gly Ser Phe Trp Leu Leu Leu Ser Phe Ala Ala Leu Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Thr Glu Glu Leu Ala Lys Thr Phe Leu Glu Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Glu Leu Ser Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Asp Glu Asn Val Gln Lys Met Asn Glu 
    50                  55                  60                  


Ala Gly Ala Lys Trp Ser Ala Phe Tyr Glu Glu Gln Ser Lys Leu Ala 
65                  70                  75                  80  


Lys Thr Tyr Pro Leu Ala Glu Ile His Asn Thr Thr Val Lys Arg Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Ser Gly Ser Ser Val Leu Ser Ala Asp Lys 
            100                 105                 110         


Ser Gln Arg Leu Asn Thr Ile Leu Asn Ala Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Ala Cys Asn Pro Asn Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asp Asp Ile Met Glu Asn Ser Lys Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Gly Trp Arg Ala Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Ala Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn Asn Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Glu Glu Trp Thr Asp Gly Tyr Asn Tyr Ser Arg Ser Gln Leu Ile Lys 
    210                 215                 220                 


Asp Val Glu His Thr Phe Thr Gln Ile Lys Pro Leu Tyr Gln His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asp Thr Tyr Pro Ser Arg Ile 
                245                 250                 255     


Ser Pro Thr Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Pro Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asn Gln Ser Trp Asp Ala 
    290                 295                 300                 


Arg Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Glu Pro 
                325                 330                 335     


Gly Asp Ser Arg Lys Val Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Lys Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Val Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Asn 
                405                 410                 415     


His Leu Lys Thr Ile Gly Leu Leu Ser Pro Gly Phe Ser Glu Asp Ser 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Glu Gln Trp Met Gln Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ala Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Ile Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Arg Ile Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Ser Glu Ala Gly Lys Lys Leu Leu Gln Met Leu Thr Leu 
545                 550                 555                 560 


Gly Lys Ser Lys Pro Trp Thr Leu Ala Leu Glu His Val Val Gly Glu 
                565                 570                 575     


Lys Lys Met Asn Val Thr Pro Leu Leu Lys Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Glu Gln Asn Arg Asn Ser Phe Val Gly Trp Asn Thr 
        595                 600                 605             


Asp Trp Arg Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Glu Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Glu Tyr Phe Ser 
                645                 650                 655     


Lys Val Lys Asn Gln Thr Ile Pro Phe Val Glu Asp Asn Val Trp Val 
            660                 665                 670         


Ser Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Ser 
        675                 680                 685             


Lys Asn Val Ser Asp Val Ile Pro Arg Ser Glu Val Glu Glu Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asp Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Ser Pro Pro Tyr Gln 
                725                 730                 735     


Pro Pro Val Thr Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Val Val Val Gly Ile Val Leu Leu Ile Val Ser Gly Ile Arg Asn Arg 
        755                 760                 765             


Arg Lys Asn Asn Gln Ala Arg Ser Glu Glu Asn Pro Tyr Ala Ser Val 
    770                 775                 780                 


Asp Leu Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln His Ala Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 


<210>  5
<211>  3596
<212>  DNA
<213>  Felis silvestris

<400>  5
gagccctgcc atttacagtg gctcctctct ttatctctga catacccgct ctctgggaat       60

gaggacattg atccagctct ggagattcta caggataacc actggagtcc ctctggattc      120

tctgttgcca tgatcccatg gttttggatg accacggaca tggacactct ttgaatttca      180

taccatgcag agtcattttt atttccctgg gtccttgact gactttagaa cagtgcccaa      240

cccaagttca aaggctgatg agcaagaaaa actcatgaag aggttttact ctagggaaag      300

ttgttcagta gatggaatct tggtgcatag ggaaagatgt caggctcttt ctggctcctt      360

ctcagctttg ctgctttaac tgctgctcaa tccaccactg aagaactggc caagacattt      420

ttggagaagt ttaaccatga agccgaagag ctgtcttatc aaagttcact tgcttcctgg      480

aattataaca ccaacatcac agacgagaat gtccaaaaaa tgaatgaggc cggggccaaa      540

tggtctgcct tttatgaaga acagtccaag cttgccaaaa cttacccgct agcagaaatt      600

cacaatacca ccgtcaaacg tcaattgcag gcccttcagc agagtgggtc atcagtgctc      660

tcagcagaca agagccaacg attgaacaca atcttaaatg caatgagcac gatctacagt      720

actggaaaag cttgtaaccc aaacaatcca caggagtgct tattacttga accaggcttg      780

gatgacatca tggaaaacag caaagactac aacgagaggc tctgggcttg ggaaggctgg      840

agggctgagg tcggcaagca gctgaggcca ttatatgaag agtacgtggc cctgaaaaat      900

gagatggcaa agagcaaaca ggtaaattat gaggactatg gagattattg gagaggagat      960

tatgaagagg agtggacaga tggctataac tatagccgca gccagttgat taaagacgtg     1020

gaacatacct tcacacagat taagccactg taccaacatc ttcatgctta cgtgagggca     1080

aagttgatgg atacctaccc ttcccgtatc agcccaactg gatgcctccc tgcccatttg     1140

cttggcgata tgtggggtcg attttggaca aatctgtacc ctttgacagt cccctttgga     1200

cagaaaccaa acatagatgt tactgatgca atggtgaacc agagctggga tgcaaggagg     1260

atattcaagg aagctgagaa attctttgtg tctgttggcc ttcccaacat gactcaagga     1320

ttctgggaaa actccatgct aaccgagcca ggagacagcc ggaaagtggt ctgccacccc     1380

acagcttggg acctagggaa gggtgacttc aggatcaaga tgtgcacaaa ggtgacgatg     1440

gatgacttcc tgacggccca tcacgagatg ggacacatcc agtatgacat ggcatatgcc     1500

gtgcaaccct tcctgctaag aaatggagct aatgaggggt tccatgaagc tgtcggggag     1560

atcatgtcac tttctgcggc tacacccaac catctgaaaa ccattggtct tctgtcacct     1620

ggtttttctg aagacagtga aacagaaata aacttcctac tcaaacaagc acttacaatt     1680

gttggaacgc taccgtttac ttatatgtta gaaaagtgga ggtggatggt ctttaagggt     1740

gaaattccca aggagcagtg gatgcaaaag tggtgggaga tgaagcgaga gatagtcggg     1800

gtggtggagc ctgtgcccca tgatgaaaca tactgtgacc ctgcatctct gttccatgtt     1860

gctaatgatt actcattcat cagatactac acaaggacca tttatcaatt ccagtttcaa     1920

gaagcccttt gtcgaatagc taaacatgaa ggtcccctgc acaaatgtga tatctcaaat     1980

tccagtgaag ccgggaagaa gctgctccaa atgctgaccc ttggaaaatc aaagccctgg     2040

accttagcat tggaacatgt tgtaggagaa aagaaaatga atgtaacacc actgctcaag     2100

tactttgagc ccttgtttac ctggctgaaa gagcagaaca ggaattcttt tgtgggatgg     2160

aacactgact ggcgtccata tgctgaccaa agcattaaag tgaggataag cctaaaatca     2220

gctcttggag acgaagcata tgaatggaat gacaatgaaa tgtacttgtt ccggtcatct     2280

gttgcatacg ccatgagaga atatttttcc aaagtcaaaa accagacgat tccttttgtg     2340

gaggataacg tgtgggtgag caatttgaaa ccaaggatct ccttcaactt ctttgtcact     2400

gcatcgaaaa atgtgtctga cgtcattcct agaagtgaag tcgaagaggc catcaggatg     2460

tcccggagcc gtatcaatga tgctttccgc ctggatgaca acagcctgga gtttctgggt     2520

attcagccaa ctctgtcacc cccttaccag ccacctgtca ccatatggct gattgttttt     2580

ggggtcgtga tgggtgtggt agtggttggt attgtcctgc tcatcgtctc cgggatcaga     2640

aatcgaagga agaacaatca agcaagaagt gaagaaaatc cttacgcctc cgtggacttg     2700

agtaaaggag aaaataatcc aggattccaa catgctgatg atgttcagac ttcattttag     2760

gaaaatctat ttcctcttga ggtgatttca ttgtatgtaa atgttgattt tacggcactg     2820

acaatatgag attataaaga tgtcattaaa tatcaaaacc atggctctgt tcaggaaagg     2880

ttgtcccaag gagacaggcc tgaagatagg gcatcttcac ttgctttcag tatttatttc     2940

tgcctcagga tttgacttct gtttatattt gagagtaata gaaaaaaggg gtctttggcc     3000

tcggtggctg tttgggggta atggatgtgg gaatgtctgt tgcacggctg gaatttctgc     3060

acgggaggct gtacgggagg gagcaagtgt tggggccttg tatggaatct ggatggatcg     3120

cttttcagga cagcgtctgc gaactggtgg agcggcaggg atccagaacg gcacacactg     3180

ctcgctttat ttcaagtata aaggctgaca cgctcttttc acgttaactt aatctaagta     3240

ctgtagtgat ttgcccacag tgatgattgg actggaccac gtgttcttcg ggttgccatg     3300

tctaaagaag agaagaatcc ggctgtttac acatgttgcc ttctcacttc caagaggctt     3360

gctcatctct ctgacaacag aaaactagcc ccaggggcct ccaggagccc cccccccccc     3420

accagagcac acctgataga aactcacttc tgtcgttctc tgtggagtga ctagacatct     3480

caggtgaatg tcaccctctg aagtgggtac ccaacgtctt caatcttacg ttcacccagt     3540

gtctgagtgg tactgagcac aaagcagaca atcaataaat acttactaga tccaca         3596


<210>  6
<211>  797
<212>  PRT
<213>  Panthera tigris

<400>  6

Leu Ser Phe Ala Ala Leu Thr Ala Ala Gln Ser Thr Thr Glu Glu Leu 
1               5                   10                  15      


Ala Lys Thr Phe Leu Glu Lys Phe Asn His Glu Ala Glu Glu Leu Ser 
            20                  25                  30          


Tyr Gln Ser Ser Leu Ala Ser Trp Asn Tyr Asn Thr Asn Ile Thr Asp 
        35                  40                  45              


Glu Asn Val Gln Lys Met Asn Glu Ala Gly Ala Lys Trp Ser Ala Phe 
    50                  55                  60                  


Tyr Glu Glu Gln Ser Lys Leu Ala Glu Thr Tyr Pro Leu Ala Glu Ile 
65                  70                  75                  80  


His Asn Thr Thr Val Lys Arg Gln Leu Gln Ala Leu Gln Gln Ser Gly 
                85                  90                  95      


Ser Ser Val Leu Ser Ala Asp Lys Ser Gln Arg Leu Asn Thr Ile Leu 
            100                 105                 110         


Asn Ala Met Ser Thr Ile Tyr Ser Thr Gly Lys Ala Cys Asn Pro Asn 
        115                 120                 125             


Asn Pro Gln Glu Cys Leu Leu Leu Glu Pro Gly Leu Asp Asp Ile Met 
    130                 135                 140                 


Glu Asn Ser Lys Asp Tyr Asn Glu Arg Leu Trp Ala Trp Glu Gly Trp 
145                 150                 155                 160 


Arg Ala Glu Val Gly Lys Gln Leu Arg Pro Leu Tyr Glu Glu Tyr Val 
                165                 170                 175     


Ala Leu Lys Asn Glu Met Ala Arg Ala Asn Asn Tyr Glu Asp Tyr Gly 
            180                 185                 190         


Asp Tyr Trp Arg Gly Asp Tyr Glu Glu Glu Trp Thr Asp Gly Tyr Asn 
        195                 200                 205             


Tyr Ser Arg Ser Gln Leu Ile Lys Asp Val Glu His Thr Phe Thr Gln 
    210                 215                 220                 


Ile Lys Pro Leu Tyr Gln His Leu His Ala Tyr Val Arg Ala Lys Leu 
225                 230                 235                 240 


Met Asp Ser Tyr Pro Ser Arg Ile Ser Pro Thr Gly Cys Leu Pro Ala 
                245                 250                 255     


His Leu Leu Gly Asp Met Trp Gly Arg Phe Trp Thr Asn Leu Tyr Pro 
            260                 265                 270         


Leu Thr Val Pro Phe Gly Gln Lys Pro Asn Ile Asp Val Thr Asp Ala 
        275                 280                 285             


Met Val Asn Gln Ser Trp Asp Ala Arg Arg Ile Phe Lys Glu Ala Glu 
    290                 295                 300                 


Lys Phe Phe Val Ser Val Gly Leu Pro Asn Met Thr Gln Gly Phe Trp 
305                 310                 315                 320 


Glu Asn Ser Met Leu Thr Glu Pro Gly Asn Ser Gln Lys Val Val Cys 
                325                 330                 335     


His Pro Thr Ala Trp Asp Leu Gly Lys Gly Asp Phe Arg Ile Lys Met 
            340                 345                 350         


Cys Thr Lys Val Thr Met Asp Asp Phe Leu Thr Ala His His Glu Met 
        355                 360                 365             


Gly His Ile Gln Tyr Asp Met Ala Tyr Ala Val Gln Pro Phe Leu Leu 
    370                 375                 380                 


Arg Asn Gly Ala Asn Glu Gly Phe His Glu Ala Val Gly Glu Ile Met 
385                 390                 395                 400 


Ser Leu Ser Ala Ala Thr Pro Asn His Leu Lys Thr Ile Gly Leu Leu 
                405                 410                 415     


Pro Pro Gly Phe Ser Glu Asp Ser Glu Thr Glu Ile Asn Phe Leu Leu 
            420                 425                 430         


Lys Gln Ala Leu Thr Ile Val Gly Thr Leu Pro Phe Thr Tyr Met Leu 
        435                 440                 445             


Glu Lys Trp Arg Trp Met Val Phe Lys Gly Glu Ile Pro Lys Glu Gln 
    450                 455                 460                 


Trp Met Gln Lys Trp Trp Glu Met Lys Arg Glu Ile Val Gly Val Val 
465                 470                 475                 480 


Glu Pro Val Pro His Asp Glu Thr Tyr Cys Asp Pro Ala Ser Leu Phe 
                485                 490                 495     


His Val Ala Asn Asp Tyr Ser Phe Ile Arg Tyr Tyr Thr Arg Thr Ile 
            500                 505                 510         


Tyr Gln Phe Gln Phe Gln Glu Ala Leu Cys Arg Ile Ala Lys His Glu 
        515                 520                 525             


Gly Pro Leu His Lys Cys Asp Ile Ser Asn Ser Ser Glu Ala Gly Lys 
    530                 535                 540                 


Lys Leu Leu Gln Met Leu Thr Leu Gly Lys Ser Lys Pro Trp Thr Leu 
545                 550                 555                 560 


Ala Leu Glu His Val Val Gly Glu Lys Asn Met Asn Val Thr Pro Leu 
                565                 570                 575     


Leu Lys Tyr Phe Glu Pro Leu Phe Thr Trp Leu Lys Glu Gln Asn Arg 
            580                 585                 590         


Asn Ser Phe Val Gly Trp Asn Thr Asp Trp Arg Pro Tyr Ala Asp Gln 
        595                 600                 605             


Ser Ile Lys Val Arg Ile Ser Leu Lys Ser Ala Leu Gly Asp Lys Ala 
    610                 615                 620                 


Tyr Glu Trp Asn Asp Asn Glu Met Tyr Leu Phe Arg Ser Ser Val Ala 
625                 630                 635                 640 


Tyr Ala Met Arg Glu Tyr Phe Ser Lys Val Lys Asn Gln Thr Ile Pro 
                645                 650                 655     


Phe Val Glu Asp Asn Val Trp Val Ser Asn Leu Lys Pro Arg Ile Ser 
            660                 665                 670         


Phe Asn Phe Phe Val Thr Ala Ser Lys Asn Val Ser Asp Val Ile Pro 
        675                 680                 685             


Arg Arg Glu Val Glu Glu Ala Ile Arg Met Ser Arg Ser Arg Ile Asn 
    690                 695                 700                 


Asp Ala Phe Arg Leu Asp Asp Asn Ser Leu Glu Phe Leu Gly Ile Gln 
705                 710                 715                 720 


Pro Thr Leu Ser Pro Pro Tyr Gln Pro Pro Val Thr Ile Trp Leu Ile 
                725                 730                 735     


Val Phe Gly Val Val Met Gly Val Val Val Val Gly Ile Val Leu Leu 
            740                 745                 750         


Ile Val Ser Gly Ile Arg Asn Arg Arg Lys Asn Asn Gln Ala Arg Ser 
        755                 760                 765             


Glu Glu Asn Pro Tyr Ala Ser Val Asp Leu Ser Lys Gly Glu Asn Asn 
    770                 775                 780                 


Pro Gly Phe Gln His Ala Asp Asp Val Gln Thr Ser Phe 
785                 790                 795         


<210>  7
<211>  3229
<212>  DNA
<213>  Panthera tigris

<400>  7
ctcagctttg ctgctttaac tgctgctcaa tccaccactg aagaactggc caagacattt       60

ttggagaagt ttaaccatga agccgaagag ctgtcttatc aaagttcact tgcttcctgg      120

aattataaca ccaatatcac agacgagaat gtccaaaaaa tgaatgaggc cggggccaaa      180

tggtctgcct tttatgaaga acagtccaag cttgccgaaa cttacccgct agcagaaatt      240

cacaatacca ccgtcaaacg tcaattgcag gcccttcagc agagtgggtc atcagtgctc      300

tcagcagaca agagccaacg attgaacaca atcttaaatg caatgagcac gatctacagt      360

actggaaaag cttgtaaccc aaataatcca caggagtgct tattacttga accaggcttg      420

gatgacataa tggaaaacag caaagactac aatgagaggc tctgggcttg ggaaggctgg      480

agggctgagg tcggcaagca gctgaggcca ttatatgaag agtatgtggc cctgaaaaat      540

gagatggcaa gagcaaacaa ttatgaggac tatggagatt attggagagg agattatgaa      600

gaggagtgga cagatggcta taactatagc cgcagccagt tgattaaaga tgtggaacat      660

accttcacac agattaagcc actgtaccaa catcttcatg cttacgtgag ggcaaagttg      720

atggattcct acccttcccg tatcagccca actggatgcc tccctgccca tttgcttggc      780

gatatgtggg gtcgattttg gacaaatctg taccctttga cagtcccctt tggacagaaa      840

ccaaacatag atgttactga tgcaatggtg aatcagagct gggatgcaag gaggatattc      900

aaagaagctg agaaattctt tgtgtctgtt ggccttccca acatgactca aggattctgg      960

gaaaactcca tgctaaccga gccaggcaac agccagaaag tggtctgcca ccccacagct     1020

tgggacctag ggaagggtga cttcaggatc aagatgtgca caaaggtgac gatggatgac     1080

ttcctgacag cccatcacga gatgggacac atccagtatg acatggcgta tgccgtgcaa     1140

cccttcctgc taagaaatgg agctaatgag gggttccacg aagctgtcgg ggagatcatg     1200

tcactttctg cggctacacc caaccatctg aaaaccattg gtcttctgcc acctggtttt     1260

tctgaagaca gtgaaacaga aataaacttc ctactcaaac aagcacttac aattgttgga     1320

acgctaccgt ttacttatat gttagaaaag tggaggtgga tggtctttaa gggtgaaatt     1380

cccaaggagc agtggatgca aaagtggtgg gagatgaagc gagagatagt cggggtggtg     1440

gagcctgtgc cccatgatga aacatactgt gatcctgcat ctctgttcca tgttgctaat     1500

gattactcat tcatcagata ctacacaagg accatttatc aattccagtt tcaagaagcc     1560

ctttgtcgaa tagctaaaca tgaaggtccc ctgcacaaat gtgatatctc aaattccagt     1620

gaagccggga agaagctgct ccaaatgctg acccttggaa aatcaaagcc ctggacctta     1680

gcattggaac atgttgtagg agaaaagaat atgaatgtaa caccactgct caagtacttt     1740

gagcccttgt ttacctggct gaaagagcag aacaggaatt cttttgtggg atggaacact     1800

gactggcgtc catatgctga ccaaagcatt aaagtgagga taagcctaaa atcagctctt     1860

ggagacaaag catatgaatg gaatgacaat gaaatgtact tgttccggtc atctgttgca     1920

tacgccatga gagaatattt ttccaaagtc aaaaaccaga cgattccttt tgtggaggat     1980

aacgtgtggg tgagcaattt gaaaccaagg atctccttca acttctttgt cactgcatca     2040

aaaaatgtgt ctgacgtcat tcctagacgt gaagtcgaag aggccatcag gatgtcccgg     2100

agccgtatca atgatgcttt ccgcctggat gacaacagcc tggagtttct gggtattcag     2160

ccaactctgt caccccctta ccagccacct gtcaccatat ggctgattgt ttttggggtc     2220

gtgatgggtg tggtagtggt tggtattgtc ctgctcatcg tctccgggat cagaaatcga     2280

aggaagaaca atcaagcaag aagtgaagaa aatccttacg cctccgtgga cttgagtaaa     2340

ggagaaaata atccaggatt ccaacatgct gatgatgttc agacttcatt ttaggaaaat     2400

ctatttcctc ttgaggtgat ttcattgtat gtaaatgtta attttacggc actgacaata     2460

tgagattata aagatgtcat taaatatcaa aaccatggct ctgttcagga aaggttgtcc     2520

caaggagaca ggcctgaaga gagggcatct tcacttgctt tcagtattta tttctgcctc     2580

aggatttgac ttctgtttat atttgagagt aatagaaaaa aggggtcttt ggcctcggtg     2640

gctgtttggg ggtaatggat gtgggaatgt ctgttgcacg gctggaattt ctgcacgggg     2700

ggtgctgtac ggggggaagc aagtgttggg gccttgtatg gaatctggat ggatcgcttt     2760

tcaggacagt gtccgcgaac tggcagagcg gcagggatcc agaacggcac acactgctca     2820

ctttatttca agtatagagg ctgacacact cttttcacgt taacttaatc taagtactgt     2880

agtgatttgc ccacagtgat gattggactg gaccacgtgt tcttcgggtt gccatgtcta     2940

aagaagagaa gaatcaggct gtttacacat gttgccttct cacttccaag aggcttgctc     3000

atctccctga caacagaaaa ctagccccag gggcctccag gagccccccc cccccccaga     3060

gcacacctga tagaaactca cttctgtcgt tcttgtggag tgactagaca tctcaggtga     3120

atgtcaccct ctgaagtggg tacccaacgt cttcaatctt acattcaccc agtgtctgag     3180

tggtactgag cacaaagcag acaatcaata aatacttact agatccaca                 3229


