                               SEQUENCE LISTING

<110> ASTRAZENECA AB
 
<120> COMPOSITIONS AND METHODS OF TREATING CANCER WITH CHIMERIC ANTIGEN
      RECEPTORS

<130> CARTGPC(TGF)-WO-PCT

<140>
<141>

<150> 63/014,831
<151> 2020-04-24

<160> 48    

<170> PatentIn version 3.5

<210> 1
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
    130                 135                 140                 


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile 
145                 150                 155                 160 


Gly Ser Asn Thr Val Asn Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro 
                165                 170                 175     


Lys Leu Leu Val Tyr Phe Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly 
        195                 200                 205             


Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp 
    210                 215                 220                 


Asp Ser Leu Asn Ala Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val 
225                 230                 235                 240 


Leu 
    


<210> 2
<211> 241
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr 
    130                 135                 140                 


Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asp Ile 
145                 150                 155                 160 


Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro 
                165                 170                 175     


Lys Leu Leu Ile Tyr Tyr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp 
            180                 185                 190         


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
        195                 200                 205             


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp 
    210                 215                 220                 


Asp Arg Met Tyr Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210> 3
<211> 460
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Val His Ser Glu Val Gln Leu Leu Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            180                 185                 190         


Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe 
        195                 200                 205             


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
305                 310                 315                 320 


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
                325                 330                 335     


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
            340                 345                 350         


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
        355                 360                 365             


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
    370                 375                 380                 


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
385                 390                 395                 400 


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
                405                 410                 415     


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
            420                 425                 430         


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
        435                 440                 445             


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 460 


<210> 4
<211> 318
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Val His Ser Glu Val Gln Leu Leu Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            180                 185                 190         


Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe 
        195                 200                 205             


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
305                 310                 315             


<210> 5
<211> 459
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Val His Ser Glu Val Gln Leu Leu Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            180                 185                 190         


Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe 
        195                 200                 205             


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            340                 345                 350         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        355                 360                 365             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    370                 375                 380                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
385                 390                 395                 400 


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                405                 410                 415     


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            420                 425                 430         


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
        435                 440                 445             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455                 


<210> 6
<211> 501
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gly Val His Ser Glu Val Gln Leu Leu Glu 
            20                  25                  30          


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        35                  40                  45              


Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg 
    50                  55                  60                  


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser 
65                  70                  75                  80  


Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                85                  90                  95      


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            100                 105                 110         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr 
        115                 120                 125             


Phe Asp Tyr Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu 
145                 150                 155                 160 


Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr 
                165                 170                 175     


Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
            180                 185                 190         


Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe 
        195                 200                 205             


Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys 
    210                 215                 220                 


Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp 
225                 230                 235                 240 


Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro 
                245                 250                 255     


Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly 
            260                 265                 270         


Pro Pro Cys Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        275                 280                 285             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    290                 295                 300                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
305                 310                 315                 320 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                325                 330                 335     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys 
            340                 345                 350         


Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr 
        355                 360                 365             


Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu 
    370                 375                 380                 


Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro 
385                 390                 395                 400 


Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly 
                405                 410                 415     


Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro 
            420                 425                 430         


Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr 
        435                 440                 445             


Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly 
    450                 455                 460                 


Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln 
465                 470                 475                 480 


Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln 
                485                 490                 495     


Ala Leu Pro Pro Arg 
            500     


<210> 7
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 7
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asp Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Ala Thr Trp Asp Asp Arg Met Tyr Ser Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg 
    450                 455     


<210> 8
<211> 314
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 8
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asp Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Ala Thr Trp Asp Asp Arg Met Tyr Ser Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Val 
    290                 295                 300                 


Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
305                 310                 


<210> 9
<211> 455
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 9
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asp Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Ala Thr Trp Asp Asp Arg Met Tyr Ser Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
    290                 295                 300                 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
305                 310                 315                 320 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                325                 330                 335     


Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
385                 390                 395                 400 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                405                 410                 415     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            420                 425                 430         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        435                 440                 445             


Met Gln Ala Leu Pro Pro Arg 
    450                 455 


<210> 10
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 10
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asp Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Tyr Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Ala Thr Trp Asp Asp Arg Met Tyr Ser Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
    290                 295                 300                 


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
305                 310                 315                 320 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
                325                 330                 335     


Asp Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
            340                 345                 350         


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
        355                 360                 365             


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
    370                 375                 380                 


Leu Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln 
385                 390                 395                 400 


Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu 
                405                 410                 415     


Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly 
            420                 425                 430         


Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210> 11
<211> 1383
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 11
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctggtg tacactccga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcag ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt      240

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat      300

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gaggaaagcg atactttgac tactggggcc aggggacaat ggtcaccgtc      420

tcgagtggtg gggggggcag cggtggtgga ggctctggtg gaggagggag ctcctatgag      480

ctgactcagc caccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct      540

ggaggcagct ccaacatcgg aagtaatact gtaaactggt tccggcagct cccaggaacg      600

gcccccaaac tcctcgttta ttttaataat cagcgaccct caggggtccc tgaccgattc      660

tctggctcca agtctggcac ctcggcctcc ctggccatcg gtgggctcca gtctgacgat      720

gaggctgact attactgtgt agcatgggat gactctctga atgctccggt gttcggcgga      780

gggaccaagg tcaccgtcct agagagcaaa tatggaccac catgccctcc atgtcctttt      840

tgggtcctgg tggtcgtggg aggcgtgctg gcatgttatt ctctgctggt cacagtggct      900

ttcatcatct tctgggtcaa gcgaggccgg aagaaactgc tgtacatctt caaacagcct      960

tttatgcgcc cagtgcagac aactcaggag gaagacggct gctcttgtcg gttccccgag     1020

gaagaggaag ggggatgtga gctgcgcgtg aagttttctc gaagtgccga tgctcctgca     1080

tatcagcagg gacagaacca gctgtacaac gagctgaatc tgggccggag agaggaatac     1140

gacgtgctgg ataagaggcg cggcagagac ccagaaatgg gcgggaagcc acgacggaaa     1200

aacccccagg aggggctgta taatgaactg cagaaggaca aaatggccga ggcttacagc     1260

gaaatcggga tgaagggaga gagaaggcgc ggaaaaggcc acgatggact gtatcagggc     1320

ctgagcactg ccaccaagga cacctacgat gctctgcaca tgcaggcact gccacccagg     1380

tga                                                                   1383


<210> 12
<211> 957
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 12
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctggtg tacactccga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcag ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt      240

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat      300

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gaggaaagcg atactttgac tactggggcc aggggacaat ggtcaccgtc      420

tcgagtggtg gggggggcag cggtggtgga ggctctggtg gaggagggag ctcctatgag      480

ctgactcagc caccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct      540

ggaggcagct ccaacatcgg aagtaatact gtaaactggt tccggcagct cccaggaacg      600

gcccccaaac tcctcgttta ttttaataat cagcgaccct caggggtccc tgaccgattc      660

tctggctcca agtctggcac ctcggcctcc ctggccatcg gtgggctcca gtctgacgat      720

gaggctgact attactgtgt agcatgggat gactctctga atgctccggt gttcggcgga      780

gggaccaagg tcaccgtcct agagagcaaa tatggaccac catgccctcc atgtcctttt      840

tgggtcctgg tggtcgtggg aggcgtgctg gcatgttatt ctctgctggt cacagtggct      900

ttcatcatct tctgggtccg cgtgaagttt tctcgaagtg ccgatgctcc tgcatga         957


<210> 13
<211> 1380
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 13
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctggtg tacactccga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcag ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt      240

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat      300

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gaggaaagcg atactttgac tactggggcc aggggacaat ggtcaccgtc      420

tcgagtggtg gggggggcag cggtggtgga ggctctggtg gaggagggag ctcctatgag      480

ctgactcagc caccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct      540

ggaggcagct ccaacatcgg aagtaatact gtaaactggt tccggcagct cccaggaacg      600

gcccccaaac tcctcgttta ttttaataat cagcgaccct caggggtccc tgaccgattc      660

tctggctcca agtctggcac ctcggcctcc ctggccatcg gtgggctcca gtctgacgat      720

gaggctgact attactgtgt agcatgggat gactctctga atgctccggt gttcggcgga      780

gggaccaagg tcaccgtcct agagagcaaa tatggaccac catgccctcc atgtcctttt      840

tgggtcctgg tggtcgtggg aggcgtgctg gcatgttatt ccctgctggt cactgtggcc      900

ttcatcatct tctgggtgcg gagcaagcgg agccggctgc tgcactctga ctacatgaac      960

atgactccac ggagacccgg ccctacccgg aaacattatc agccctacgc cccacccaga     1020

gattttgccg cttataggtc cagggtgaag ttttctcgca gtgcagatgc ccctgcttat     1080

cagcagggac agaatcagct gtacaacgag ctgaatctgg gcaggcgcga ggaatacgac     1140

gtgctggata agcgacgggg cagagacccc gaaatgggag ggaagcccag aaggaaaaac     1200

cctcaggagg ggctgtataa tgaactgcag aaggacaaaa tggcagaggc ctacagtgaa     1260

atcgggatga agggagagcg ccgacgggga aaaggccacg atggactgta tcagggcctg     1320

tctactgcca ccaaggacac ctacgatgcc ctgcacatgc aggctctgcc tccacgctga     1380


<210> 14
<211> 1506
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 14
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctggtg tacactccga ggtgcagctg ttggagtctg ggggaggctt ggtacagcct      120

ggggggtccc tgagactctc ctgtgcagcc tctggattca cctttagcag ctatgccatg      180

agctgggtcc gccaggctcc agggaagggg ctggagtggg tctcagctat tagtggtagt      240

ggtggtagca catactacgc agactccgtg aagggccggt tcaccatctc cagagacaat      300

tccaagaaca cgctgtatct gcaaatgaac agcctgagag ccgaggacac ggccgtgtat      360

tactgtgcga gaggaaagcg atactttgac tactggggcc aggggacaat ggtcaccgtc      420

tcgagtggtg gggggggcag cggtggtgga ggctctggtg gaggagggag ctcctatgag      480

ctgactcagc caccctcagc gtctgggacc cccgggcaga gggtcaccat ctcttgttct      540

ggaggcagct ccaacatcgg aagtaatact gtaaactggt tccggcagct cccaggaacg      600

gcccccaaac tcctcgttta ttttaataat cagcgaccct caggggtccc tgaccgattc      660

tctggctcca agtctggcac ctcggcctcc ctggccatcg gtgggctcca gtctgacgat      720

gaggctgact attactgtgt agcatgggat gactctctga atgctccggt gttcggcgga      780

gggaccaagg tcaccgtcct agagagcaaa tatggaccac catgccctcc atgtcctttt      840

tgggtcctgg tggtcgtggg aggcgtgctg gcatgttatt ccctgctggt cactgtggcc      900

ttcatcatct tctgggtgcg gagcaagcgg agccggctgc tgcactctga ctacatgaac      960

atgactccac ggagacccgg ccctacccgg aaacattatc agccctacgc cccacccaga     1020

gattttgccg cttataggtc caagcgcggc cgaaagaaac tgctgtacat cttcaaacag     1080

cccttcatga gacccgtcca gacaactcag gaggaagacg gctgcagctg taggttcccc     1140

gaggaagagg aagggggatg tgagctgagg gtgaagtttt ctcgcagtgc agatgcccct     1200

gcttatcagc agggacagaa tcagctgtac aacgagctga atctgggcag gcgcgaggaa     1260

tacgacgtgc tggataagcg acggggcaga gaccccgaaa tgggagggaa gcccagaagg     1320

aaaaaccctc aggaggggct gtataatgaa ctgcagaagg acaaaatggc agaggcctac     1380

agtgaaatcg ggatgaaggg agagcgccga cggggaaaag gccacgatgg actgtatcag     1440

ggcctgtcta ctgccaccaa ggacacctac gatgccctgc acatgcaggc tctgcctcca     1500

cgctga                                                                1506


<210> 15
<211> 1371
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 15
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tccagctgct ggagagcgga ggaggactgg tgcagcctgg aggaagtctg      120

cgactgtcat gcgccgctag cggcttcacc ttcagctcct atgcaatgag ctgggtgcga      180

caggcaccag gcaaggggct ggagtgggtc tccgctatct ccggctctgg aggctctact      240

tactatgcag acagtgtgaa ggggcggttc acaatctcca gagataactc taagaacact      300

ctgtacctgc agatgaactc tctgagagct gaggacaccg cagtgtacta ttgcgccaag      360

ggcaaaaggt actttgatta ttggggacag ggcactatgg tgaccgtctc tagtggagga      420

ggaggaagcg gaggaggagg atccggcgga ggaggcagtc agtcagtgct gacacagcca      480

cctagcgcct ccggaacccc aggacagcgg gtcacaatct cttgtagtgg gggatcaagc      540

gacattggga gcaacaccgt gaattggtat cagcagctgc ctggaacagc tccaaagctg      600

ctgatctact ataacaatca gaggccctcc ggcgtccctg atcgcttctc aggcagcaaa      660

tccgggactt ctgcaagtct ggccattagt ggcctgcagt cagaggacga agccgattac      720

tattgtgcta cctgggacga taggatgtac tctcccgtgt tcggcggggg aacaaagctg      780

actgtcctgg agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttattct ctgctggtca cagtggcttt catcatcttc      900

tgggtcaagc gaggccggaa gaaactgctg tacatcttca aacagccttt tatgcgccca      960

gtgcagacaa ctcaggagga agacggctgc tcttgtcggt tccccgagga agaggaaggg     1020

ggatgtgagc tgcgcgtgaa gttttctcga agtgccgatg ctcctgcata tcagcaggga     1080

cagaaccagc tgtacaacga gctgaatctg ggccggagag aggaatacga cgtgctggat     1140

aagaggcgcg gcagagaccc agaaatgggc gggaagccac gacggaaaaa cccccaggag     1200

gggctgtata atgaactgca gaaggacaaa atggccgagg cttacagcga aatcgggatg     1260

aagggagaga gaaggcgcgg aaaaggccac gatggactgt atcagggcct gagcactgcc     1320

accaaggaca cctacgatgc tctgcacatg caggcactgc cacccaggtg a              1371


<210> 16
<211> 945
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 16
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tccagctgct ggagagcgga ggaggactgg tgcagcctgg aggaagtctg      120

cgactgtcat gcgccgctag cggcttcacc ttcagctcct atgcaatgag ctgggtgcga      180

caggcaccag gcaaggggct ggagtgggtc tccgctatct ccggctctgg aggctctact      240

tactatgcag acagtgtgaa ggggcggttc acaatctcca gagataactc taagaacact      300

ctgtacctgc agatgaactc tctgagagct gaggacaccg cagtgtacta ttgcgccaag      360

ggcaaaaggt actttgatta ttggggacag ggcactatgg tgaccgtctc tagtggagga      420

ggaggaagcg gaggaggagg atccggcgga ggaggcagtc agtcagtgct gacacagcca      480

cctagcgcct ccggaacccc aggacagcgg gtcacaatct cttgtagtgg gggatcaagc      540

gacattggga gcaacaccgt gaattggtat cagcagctgc ctggaacagc tccaaagctg      600

ctgatctact ataacaatca gaggccctcc ggcgtccctg atcgcttctc aggcagcaaa      660

tccgggactt ctgcaagtct ggccattagt ggcctgcagt cagaggacga agccgattac      720

tattgtgcta cctgggacga taggatgtac tctcccgtgt tcggcggggg aacaaagctg      780

actgtcctgg agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttactcc ctgctggtca ctgtggcctt catcatcttc      900

tgggtgcggg tgaagttttc tcgcagtgcc gacgctcccg catga                      945


<210> 17
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 17
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tccagctgct ggagagcgga ggaggactgg tgcagcctgg aggaagtctg      120

cgactgtcat gcgccgctag cggcttcacc ttcagctcct atgcaatgag ctgggtgcga      180

caggcaccag gcaaggggct ggagtgggtc tccgctatct ccggctctgg aggctctact      240

tactatgcag acagtgtgaa ggggcggttc acaatctcca gagataactc taagaacact      300

ctgtacctgc agatgaactc tctgagagct gaggacaccg cagtgtacta ttgcgccaag      360

ggcaaaaggt actttgatta ttggggacag ggcactatgg tgaccgtctc tagtggagga      420

ggaggaagcg gaggaggagg atccggcgga ggaggcagtc agtcagtgct gacacagcca      480

cctagcgcct ccggaacccc aggacagcgg gtcacaatct cttgtagtgg gggatcaagc      540

gacattggga gcaacaccgt gaattggtat cagcagctgc ctggaacagc tccaaagctg      600

ctgatctact ataacaatca gaggccctcc ggcgtccctg atcgcttctc aggcagcaaa      660

tccgggactt ctgcaagtct ggccattagt ggcctgcagt cagaggacga agccgattac      720

tattgtgcta cctgggacga taggatgtac tctcccgtgt tcggcggggg aacaaagctg      780

actgtcctgg agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttattcc ctgctggtca cagtggcctt catcatcttc      900

tgggtgcgga gcaagcggag ccggctgctg cactctgact acatgaacat gaccccccgg      960

agacccggcc ctacaagaaa gcattatcag ccttacgccc cacccaggga cttcgcagct     1020

tatcgctccc gagtgaaatt ttctcgcagt gcagatgccc ccgcttatca gcagggccag     1080

aatcagctgt acaacgagct gaatctgggg aggcgcgagg aatacgacgt gctggataag     1140

cgacggggcc gggaccccga aatgggagga aagcctagaa ggaaaaaccc acaggagggc     1200

ctgtataatg aactgcagaa ggacaaaatg gcagaggcct acagcgaaat cggaatgaag     1260

ggagagcgcc gacggggcaa aggacacgat ggcctgtatc aggggctgag caccgccaca     1320

aaggacacct acgatgccct gcacatgcag gctctgcctc cacgctga                  1368


<210> 18
<211> 1494
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tccagctgct ggagagcgga ggaggactgg tgcagcctgg aggaagtctg      120

cgactgtcat gcgccgctag cggcttcacc ttcagctcct atgcaatgag ctgggtgcga      180

caggcaccag gcaaggggct ggagtgggtc tccgctatct ccggctctgg aggctctact      240

tactatgcag acagtgtgaa ggggcggttc acaatctcca gagataactc taagaacact      300

ctgtacctgc agatgaactc tctgagagct gaggacaccg cagtgtacta ttgcgccaag      360

ggcaaaaggt actttgatta ttggggacag ggcactatgg tgaccgtctc tagtggagga      420

ggaggaagcg gaggaggagg atccggcgga ggaggcagtc agtcagtgct gacacagcca      480

cctagcgcct ccggaacccc aggacagcgg gtcacaatct cttgtagtgg gggatcaagc      540

gacattggga gcaacaccgt gaattggtat cagcagctgc ctggaacagc tccaaagctg      600

ctgatctact ataacaatca gaggccctcc ggcgtccctg atcgcttctc aggcagcaaa      660

tccgggactt ctgcaagtct ggccattagt ggcctgcagt cagaggacga agccgattac      720

tattgtgcta cctgggacga taggatgtac tctcccgtgt tcggcggggg aacaaagctg      780

actgtcctgg agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttattcc ctgctggtca ctgtggcctt catcatcttc      900

tgggtgcgga gcaagcggag ccggctgctg cactctgact acatgaacat gactccacgg      960

agacccggcc ctacccggaa acattatcag ccctacgccc cacccagaga ttttgccgct     1020

tataggtcca agcgcggccg aaagaaactg ctgtacatct tcaaacagcc cttcatgaga     1080

cccgtccaga caactcagga ggaagacggc tgcagctgta ggttccccga ggaagaggaa     1140

gggggatgtg agctgagggt gaagttttct cgcagtgcag atgcccctgc ttatcagcag     1200

ggacagaatc agctgtacaa cgagctgaat ctgggcaggc gcgaggaata cgacgtgctg     1260

gataagcgac ggggcagaga ccccgaaatg ggagggaagc ccagaaggaa aaaccctcag     1320

gaggggctgt ataatgaact gcagaaggac aaaatggcag aggcctacag tgaaatcggg     1380

atgaagggag agcgccgacg gggaaaaggc cacgatggac tgtatcaggg cctgtctact     1440

gccaccaagg acacctacga tgccctgcac atgcaggctc tgcctccacg ctga           1494


<210> 19
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
            100                 105                 110         


Tyr Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg Gly 
    290                 295                 300                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
305                 310                 315                 320 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                325                 330                 335     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            340                 345                 350         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        355                 360                 365             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    370                 375                 380                 


Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg 
    450                 455     


<210> 20
<211> 497
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 20
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Asp Val Val Met Thr Gln Ser Pro Leu Ser 
            20                  25                  30          


Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 
        35                  40                  45              


Gln Ser Leu Val His Ser Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu 
    50                  55                  60                  


Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn 
65                  70                  75                  80  


Arg Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
                85                  90                  95      


Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 
            100                 105                 110         


Tyr Tyr Cys Ser Gln Asn Thr His Val Pro Pro Thr Phe Gly Gln Gly 
        115                 120                 125             


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
145                 150                 155                 160 


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Asp Tyr Glu Met His Trp Val Arg Gln Ala Pro Gly Gln 
            180                 185                 190         


Gly Leu Glu Trp Met Gly Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala 
        195                 200                 205             


Tyr Ser Gln Lys Phe Lys Gly Arg Val Thr Leu Thr Ala Asp Lys Ser 
    210                 215                 220                 


Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Thr Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln 
                245                 250                 255     


Gly Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr 
        275                 280                 285             


Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser Lys 
    290                 295                 300                 


Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg Arg 
305                 310                 315                 320 


Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg Asp 
                325                 330                 335     


Phe Ala Ala Tyr Arg Ser Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile 
            340                 345                 350         


Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp 
        355                 360                 365             


Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
    370                 375                 380                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
385                 390                 395                 400 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                405                 410                 415     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            420                 425                 430         


Pro Gln Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln 
        435                 440                 445             


Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu 
    450                 455                 460                 


Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr 
465                 470                 475                 480 


Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro 
                485                 490                 495     


Arg 
    


<210> 21
<211> 457
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Gln Val Gln Leu Val Gln Ser Gly Gly Gly 
            20                  25                  30          


Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Gly Leu His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Pro Asp Asp 
            100                 105                 110         


Thr Ala Leu Tyr Phe Cys Ala Arg Gly Trp Phe Val Glu Pro Leu Ser 
        115                 120                 125             


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln 
145                 150                 155                 160 


Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys 
                165                 170                 175     


Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln 
            180                 185                 190         


Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln 
        195                 200                 205             


Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr 
    210                 215                 220                 


Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp 
225                 230                 235                 240 


Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly 
                245                 250                 255     


Thr Gly Thr Lys Leu Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys 
            260                 265                 270         


Pro Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala 
        275                 280                 285             


Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys 
    290                 295                 300                 


Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg 
305                 310                 315                 320 


Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro 
                325                 330                 335     


Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser 
            340                 345                 350         


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
        355                 360                 365             


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
    370                 375                 380                 


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
385                 390                 395                 400 


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
                405                 410                 415     


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
            420                 425                 430         


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
        435                 440                 445             


Leu His Met Gln Ala Leu Pro Pro Arg 
    450                 455         


<210> 22
<211> 1371
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgatg tcgtgatgac gcagagccct ctctctcttc ccgttacccc tggtgaaccc      120

gcatcaataa gttgccgctc cagtcaatca cttgtacatt caaatcgcaa tacctacctg      180

cactggtatt tgcagaagcc gggacaatcc cctcaattgt tgatatataa ggtatccaat      240

cgcttttctg gagttcctga tagattcagc ggatccgggt ctggtactga tttcactctg      300

aaaatatcca gggtcgaagc tgaggacgta ggcgtatatt attgctctca gaacacgcat      360

gtcccgccga ctttcggcca gggcactaaa cttgagatca agggtggggg gggcagcggt      420

ggtggaggct ctggtggagg agggagccag gtccaactcg ttcaaagtgg cgcagaggtc      480

aaaaagccag gcgcgagcgt taaagtatca tgtaaggcca gcggttatac tttcactgat      540

tatgaaatgc actgggtgcg acaagccccc gggcaaggtc ttgagtggat gggtgcactt      600

gatccaaaaa ctggggatac tgcctatagc cagaaattca aagggcgcgt cacactcact      660

gccgacaaaa gtacgagcac agcttatatg gaattgagtt cactgacgag cgaggatacg      720

gcagtttatt actgtacgcg cttctactct tacacttatt gggggcaagg cactttggtt      780

actgtgtcct ctgacaagac ccatacgtgt ccaccgtgtc ccttctgggt attggttgtg      840

gtcggcggtg tccttgcttg ttacagcctt ctcgtgacag tcgcattcat aattttttgg      900

gtgaaaagag gtcggaaaaa gttgctgtat attttcaaac aaccctttat gagacctgta      960

caaacgactc aggaagagga tggttgtagt tgcaggtttc cggaggagga ggaaggtggg     1020

tgcgaactgc gggtgaaatt tagtagaagc gctgacgcac cagcttacca acaaggacag     1080

aaccaattgt acaacgagct taacttgggt aggagggagg aatatgatgt actggacaaa     1140

aggcgaggtc gcgatccgga aatgggaggc aagccacagc gccggaaaaa cccgcaggaa     1200

ggcttgtaca acgaacttca gaaagataaa atggcagaag catactccga aatagggatg     1260

aaaggtgaac ggcggcgagg caagggccac gacggtctgt accaagggtt gtcaacggca     1320

actaaagaca cgtatgatgc acttcatatg caagctctgc cacccaggtg a              1371


<210> 23
<211> 1494
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 23
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgatg tcgtgatgac gcagagccct ctctctcttc ccgttacccc tggtgaaccc      120

gcatcaataa gttgccgctc cagtcaatca cttgtacatt caaatcgcaa tacctacctg      180

cactggtatt tgcagaagcc gggacaatcc cctcaattgt tgatatataa ggtatccaat      240

cgcttttctg gagttcctga tagattcagc ggatccgggt ctggtactga tttcactctg      300

aaaatatcca gggtcgaagc tgaggacgta ggcgtatatt attgctctca gaacacgcat      360

gtcccgccga ctttcggcca gggcactaaa cttgagatca agggtggggg gggcagcggt      420

ggtggaggct ctggtggagg agggagccag gtccaactcg ttcaaagtgg cgcagaggtc      480

aaaaagccag gcgcgagcgt taaagtatca tgtaaggcca gcggttatac tttcactgat      540

tatgaaatgc actgggtgcg acaagccccc gggcaaggtc ttgagtggat gggtgcactt      600

gatccaaaaa ctggggatac tgcctatagc cagaaattca aagggcgcgt cacactcact      660

gccgacaaaa gtacgagcac agcttatatg gaattgagtt cactgacgag cgaggatacg      720

gcagtttatt actgtacgcg cttctactct tacacttatt gggggcaagg cactttggtt      780

actgtgtcct ctgacaagac ccatacgtgt ccaccgtgtc ccttctgggt attggttgtg      840

gtcggcggtg tccttgcttg ttacagcctt ctcgtgacag tcgcattcat aattttttgg      900

gtgcggagca agcggagccg gctgctgcac tctgactaca tgaacatgac tccacggaga      960

cccggcccta cccggaaaca ttatcagccc tacgccccac ccagagattt tgccgcttat     1020

aggtccaaaa gaggtcggaa aaagttgctg tatattttca aacaaccctt tatgagacct     1080

gtacaaacga ctcaggaaga ggatggttgt agttgcaggt ttccggagga ggaggaaggt     1140

gggtgcgaac tgcgggtgaa atttagtaga agcgctgacg caccagctta ccaacaagga     1200

cagaaccaat tgtacaacga gcttaacttg ggtaggaggg aggaatatga tgtactggac     1260

aaaaggcgag gtcgcgatcc ggaaatggga ggcaagccac agcgccggaa aaacccgcag     1320

gaaggcttgt acaacgaact tcagaaagat aaaatggcag aagcatactc cgaaataggg     1380

atgaaaggtg aacggcggcg aggcaagggc cacgacggtc tgtaccaagg gttgtcaacg     1440

gcaactaaag acacgtatga tgcacttcat atgcaagctc tgccacccag gtga           1494


<210> 24
<211> 1374
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctcagg tccagcttgt gcaaagcgga ggaggagtgg tacagcctgg ccgctctttg      120

agactgtctt gtgcggccag tggatttaca ttctcttctt atgggttgca ttgggtcaga      180

caagcaccgg gcaaaggatt ggaatgggtc gcggccatta gctatgatgg ctcaaagaaa      240

tattatgccg attccgtaaa agggaggttg acaataagcc gggataacag caagaacact      300

ttgtatcttc agatgaatag cctccgaccg gacgacacgg cactgtattt ttgcgcacgc      360

gggtggtttg tagaacccct gagttgggga caaggtactc ttgtcacggt atcttctggc      420

ggaggtggga gtggtggggg tggcagtggc gggggtgggt cacaaagcgt gcttacacaa      480

cctccttctg cgagcggaac tccgggacaa cgggttacga tttcatgctc cggctcaagt      540

agcaatatag gatcaaatac agtgaattgg tatcaacaac tccctggcac agcgcccaag      600

ctgctgatct actctaataa ccagaggccg agtggtgtgc cagataggtt cagtggctct      660

aaatcaggta ctagcgcgag cctcgccatt tcaggacttc aatcagagga tgaagcggac      720

tactactgtg ccgcgtggga tgattcactt aatggatatg ttttcgggac cggaacaaaa      780

ttgacggtat tggagagcaa atatggacca ccatgccctc catgtccttt ttgggtcctg      840

gtggtcgtgg gaggcgtgct ggcatgttat tctctgctgg tcacagtggc tttcatcatc      900

ttctgggtca agcgaggccg gaagaaactg ctgtacatct tcaaacagcc ttttatgcgc      960

ccagtgcaga caactcagga ggaagacggc tgctcttgtc ggttccccga ggaagaggaa     1020

gggggatgtg agctgcgcgt gaagttttct cgaagtgccg atgctcctgc atatcagcag     1080

ggacagaacc agctgtacaa cgagctgaat ctgggccgga gagaggaata cgacgtgctg     1140

gataagaggc gcggcagaga cccagaaatg ggcgggaagc cacgacggaa aaacccccag     1200

gaggggctgt ataatgaact gcagaaggac aaaatggccg aggcttacag cgaaatcggg     1260

atgaagggag agagaaggcg cggaaaaggc cacgatggac tgtatcaggg cctgagcact     1320

gccaccaagg acacctacga tgctctgcac atgcaggcac tgccacccag gtga           1374


<210> 25
<211> 456
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Phe Arg Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg 
    450                 455     


<210> 26
<211> 1368
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      180

caggctccag ggaaggggct ggagtgggtc tcagctatta gtggtagtgg tggtagcaca      240

tactacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtgtatta ctgtgcgaga      360

ggaaagcgat actttgacta ctggggccag gggacaatgg tcaccgtctc gagtggtggg      420

gggggcagcg gtggtggagg ctctggtgga ggagggagct cctatgagct gactcagcca      480

ccctcagcgt ctgggacccc cgggcagagg gtcaccatct cttgttctgg aggcagctcc      540

aacatcggaa gtaatactgt aaactggttc cggcagctcc caggaacggc ccccaaactc      600

ctcgtttatt ttaataatca gcgaccctca ggggtccctg accgattctc tggctccaag      660

tctggcacct cggcctccct ggccatcggt gggctccagt ctgacgatga ggctgactat      720

tactgtgtag catgggatga ctctctgaat gctccggtgt tcggcggagg gaccaaggtc      780

accgtcctag agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttattct ctgctggtca cagtggcttt catcatcttc      900

tgggtcaagc gaggccggaa gaaactgctg tacatcttca aacagccttt tatgcgccca      960

gtgcagacaa ctcaggagga agacggctgc tcttgtcggt tccccgagga agaggaaggg     1020

ggatgtgagc tgcgcgtgaa gttttctcga agtgccgatg ctcctgcata tcagcaggga     1080

cagaaccagc tgtacaacga gctgaatctg ggccggagag aggaatacga cgtgctggat     1140

aagaggcgcg gcagagaccc agaaatgggc gggaagccac gacggaaaaa cccccaggag     1200

gggctgtata atgaactgca gaaggacaaa atggccgagg cttacagcga aatcgggatg     1260

aagggagaga gaaggcgcgg aaaaggccac gatggactgt atcagggcct gagcactgcc     1320

accaaggaca cctacgatgc tctgcacatg caggcactgc cacccagg                  1368


<210> 27
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Lys Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 28
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 28
Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Phe Arg Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Val Tyr Phe Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Gly Gly Leu Gln 
65                  70                  75                  80  


Ser Asp Asp Glu Ala Asp Tyr Tyr Cys Val Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Ala Pro Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210> 29
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Lys Arg Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210> 30
<211> 110
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 30
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asp Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Arg Met 
                85                  90                  95      


Tyr Ser Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110 


<210> 31
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Arg Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Asn 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
    130                 135                 140                 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr Glu 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
                165                 170                 175     


Ala Leu Asp Pro Lys Thr Gly Asp Thr Ala Tyr Ser Gln Lys Phe Lys 
            180                 185                 190         


Gly Arg Val Thr Leu Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
        195                 200                 205             


Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Thr 
    210                 215                 220                 


Arg Phe Tyr Ser Tyr Thr Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210> 32
<211> 242
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 32
Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ala Ile Ser Tyr Asp Gly Ser Lys Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Leu Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Leu Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Trp Phe Val Glu Pro Leu Ser Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Asn Gly Tyr Val Phe Gly Thr Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu 
        


<210> 33
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 33
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac      180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagaggaaag      300

cgatactttg actactgggg ccaggggaca atggtcaccg tctcgagtgg tggggggggc      360

agcggtggtg gaggctctgg tggaggaggg agctcctatg agctgactca gccaccctca      420

gcgtctggga cccccgggca gagggtcacc atctcttgtt ctggaggcag ctccaacatc      480

ggaagtaata ctgtaaactg gttccggcag ctcccaggaa cggcccccaa actcctcgtt      540

tattttaata atcagcgacc ctcaggggtc cctgaccgat tctctggctc caagtctggc      600

acctcggcct ccctggccat cggtgggctc cagtctgacg atgaggctga ctattactgt      660

gtagcatggg atgactctct gaatgctccg gtgttcggcg gagggaccaa ggtcaccgtc      720

cta                                                                    723


<210> 34
<211> 723
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
gaggtccagc tgctggagag cggaggagga ctggtgcagc ctggaggaag tctgcgactg       60

tcatgcgccg ctagcggctt caccttcagc tcctatgcaa tgagctgggt gcgacaggca      120

ccaggcaagg ggctggagtg ggtctccgct atctccggct ctggaggctc tacttactat      180

gcagacagtg tgaaggggcg gttcacaatc tccagagata actctaagaa cactctgtac      240

ctgcagatga actctctgag agctgaggac accgcagtgt actattgcgc caagggcaaa      300

aggtactttg attattgggg acagggcact atggtgaccg tctctagtgg aggaggagga      360

agcggaggag gaggatccgg cggaggaggc agtcagtcag tgctgacaca gccacctagc      420

gcctccggaa ccccaggaca gcgggtcaca atctcttgta gtgggggatc aagcgacatt      480

gggagcaaca ccgtgaattg gtatcagcag ctgcctggaa cagctccaaa gctgctgatc      540

tactataaca atcagaggcc ctccggcgtc cctgatcgct tctcaggcag caaatccggg      600

acttctgcaa gtctggccat tagtggcctg cagtcagagg acgaagccga ttactattgt      660

gctacctggg acgataggat gtactctccc gtgttcggcg ggggaacaaa gctgactgtc      720

ctg                                                                    723


<210> 35
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 35
gatgtcgtga tgacgcagag ccctctctct cttcccgtta cccctggtga acccgcatca       60

ataagttgcc gctccagtca atcacttgta cattcaaatc gcaataccta cctgcactgg      120

tatttgcaga agccgggaca atcccctcaa ttgttgatat ataaggtatc caatcgcttt      180

tctggagttc ctgatagatt cagcggatcc gggtctggta ctgatttcac tctgaaaata      240

tccagggtcg aagctgagga cgtaggcgta tattattgct ctcagaacac gcatgtcccg      300

ccgactttcg gccagggcac taaacttgag atcaagggtg gggggggcag cggtggtgga      360

ggctctggtg gaggagggag ccaggtccaa ctcgttcaaa gtggcgcaga ggtcaaaaag      420

ccaggcgcga gcgttaaagt atcatgtaag gccagcggtt atactttcac tgattatgaa      480

atgcactggg tgcgacaagc ccccgggcaa ggtcttgagt ggatgggtgc acttgatcca      540

aaaactgggg atactgccta tagccagaaa ttcaaagggc gcgtcacact cactgccgac      600

aaaagtacga gcacagctta tatggaattg agttcactga cgagcgagga tacggcagtt      660

tattactgta cgcgcttcta ctcttacact tattgggggc aaggcacttt ggttactgtg      720

tcctct                                                                 726


<210> 36
<211> 726
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
caggtccagc ttgtgcaaag cggaggagga gtggtacagc ctggccgctc tttgagactg       60

tcttgtgcgg ccagtggatt tacattctct tcttatgggt tgcattgggt cagacaagca      120

ccgggcaaag gattggaatg ggtcgcggcc attagctatg atggctcaaa gaaatattat      180

gccgattccg taaaagggag gttgacaata agccgggata acagcaagaa cactttgtat      240

cttcagatga atagcctccg accggacgac acggcactgt atttttgcgc acgcgggtgg      300

tttgtagaac ccctgagttg gggacaaggt actcttgtca cggtatcttc tggcggaggt      360

gggagtggtg ggggtggcag tggcgggggt gggtcacaaa gcgtgcttac acaacctcct      420

tctgcgagcg gaactccggg acaacgggtt acgatttcat gctccggctc aagtagcaat      480

ataggatcaa atacagtgaa ttggtatcaa caactccctg gcacagcgcc caagctgctg      540

atctactcta ataaccagag gccgagtggt gtgccagata ggttcagtgg ctctaaatca      600

ggtactagcg cgagcctcgc catttcagga cttcaatcag aggatgaagc ggactactac      660

tgtgccgcgt gggatgattc acttaatgga tatgttttcg ggaccggaac aaaattgacg      720

gtattg                                                                 726


<210> 37
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210> 38
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210> 39
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gly Lys Arg Tyr Phe Asp Tyr 
1               5           


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Ser Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210> 41
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Phe Asn Asn Gln Arg Pro Ser 
1               5           


<210> 42
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Val Ala Trp Asp Asp Ser Leu Asn Ala Pro Val 
1               5                   10      


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Ser Gly Gly Ser Ser Asp Ile Gly Ser Asn Thr Val Asn 
1               5                   10              


<210> 44
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 44
Tyr Asn Asn Gln Arg Pro Ser 
1               5           


<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 45
Ala Thr Trp Asp Asp Arg Met Tyr Ser Pro Val 
1               5                   10      


<210> 46
<211> 2013
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 46
atgctgctgc tggtgacaag cctgctgctg tgcgaactgc cccatcccgc cttcctgctg       60

attcctgagg tgcagctgtt ggagtctggg ggaggcttgg tacagcctgg ggggtccctg      120

agactctcct gtgcagcctc tggattcacc tttagcagct atgccatgag ctgggtccgc      180

caggctccag ggaaggggct ggagtgggtc tcagctatta gtggtagtgg tggtagcaca      240

tactacgcag actccgtgaa gggccggttc accatctcca gagacaattc caagaacacg      300

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtgtatta ctgtgcgaga      360

ggaaagcgat actttgacta ctggggccag gggacaatgg tcaccgtctc gagtggtggg      420

gggggcagcg gtggtggagg ctctggtgga ggagggagct cctatgagct gactcagcca      480

ccctcagcgt ctgggacccc cgggcagagg gtcaccatct cttgttctgg aggcagctcc      540

aacatcggaa gtaatactgt aaactggttc cggcagctcc caggaacggc ccccaaactc      600

ctcgtttatt ttaataatca gcgaccctca ggggtccctg accgattctc tggctccaag      660

tctggcacct cggcctccct ggccatcggt gggctccagt ctgacgatga ggctgactat      720

tactgtgtag catgggatga ctctctgaat gctccggtgt tcggcggagg gaccaaggtc      780

accgtcctag agagcaaata tggaccacca tgccctccat gtcctttttg ggtcctggtg      840

gtcgtgggag gcgtgctggc atgttattct ctgctggtca cagtggcttt catcatcttc      900

tgggtcaagc gaggccggaa gaaactgctg tacatcttca aacagccttt tatgcgccca      960

gtgcagacaa ctcaggagga agacggctgc tcttgtcggt tccccgagga agaggaaggg     1020

ggatgtgagc tgcgcgtgaa gttttctcga agtgccgatg ctcctgcata tcagcaggga     1080

cagaaccagc tgtacaacga gctgaatctg ggccggagag aggaatacga cgtgctggat     1140

aagaggcgcg gcagagaccc agaaatgggc gggaagccac gacggaaaaa cccccaggag     1200

gggctgtata atgaactgca gaaggacaaa atggccgagg cttacagcga aatcgggatg     1260

aagggagaga gaaggcgcgg aaaaggccac gatggactgt atcagggcct gagcactgcc     1320

accaaggaca cctacgatgc tctgcacatg caggcactgc cacccagggg tagcggcgag     1380

ggcagaggaa gtcttctaac atgcggtgac gtggaggaga atcccggccc tatgggtcgg     1440

gggctgctca ggggcctgtg gccgctgcac atcgtcctgt ggacgcgtat cgccagcacg     1500

atcccaccgc acgttcagaa gtcggttaat aacgacatga tagtcactga caacaacggt     1560

gcagtcaagt ttccacaact gtgtaaattt tgtgatgtga gattttccac ctgtgacaac     1620

cagaaatcct gcatgagcaa ctgcagcatc acctccatct gtgagaagcc acaggaagtc     1680

tgtgtggctg tatggagaaa gaatgacgag aacataacac tagagacagt ttgccatgac     1740

cccaagctcc cctaccatga ctttattctg gaagatgctg cttctccaaa gtgcattatg     1800

aaggaaaaaa aaaagcctgg tgagactttc ttcatgtgtt cctgtagctc tgatgagtgc     1860

aatgacaaca tcatcttctc agaagaatat aacaccagca atcctgactt gttgctagtc     1920

atatttcaag tgacaggcat cagcctcctg ccaccactgg gagttgccat atctgtcatc     1980

atcatcttct actgctaccg cgttaaccgg cag                                  2013


<210> 47
<211> 671
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr 
65                  70                  75                  80  


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Lys Arg Tyr Phe Asp Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Ser Tyr Glu Leu Thr Gln Pro 
145                 150                 155                 160 


Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser 
                165                 170                 175     


Gly Gly Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Phe Arg Gln 
            180                 185                 190         


Leu Pro Gly Thr Ala Pro Lys Leu Leu Val Tyr Phe Asn Asn Gln Arg 
        195                 200                 205             


Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser 
    210                 215                 220                 


Ala Ser Leu Ala Ile Gly Gly Leu Gln Ser Asp Asp Glu Ala Asp Tyr 
225                 230                 235                 240 


Tyr Cys Val Ala Trp Asp Asp Ser Leu Asn Ala Pro Val Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Val Thr Val Leu Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
            260                 265                 270         


Pro Cys Pro Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
        275                 280                 285             


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
    290                 295                 300                 


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
305                 310                 315                 320 


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
                325                 330                 335     


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
            340                 345                 350         


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
        355                 360                 365             


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
    370                 375                 380                 


Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu 
385                 390                 395                 400 


Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser 
                405                 410                 415     


Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly 
            420                 425                 430         


Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu 
        435                 440                 445             


His Met Gln Ala Leu Pro Pro Arg Gly Ser Gly Glu Gly Arg Gly Ser 
    450                 455                 460                 


Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Gly Arg 
465                 470                 475                 480 


Gly Leu Leu Arg Gly Leu Trp Pro Leu His Ile Val Leu Trp Thr Arg 
                485                 490                 495     


Ile Ala Ser Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn Asp 
            500                 505                 510         


Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys 
        515                 520                 525             


Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys 
    530                 535                 540                 


Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val 
545                 550                 555                 560 


Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr 
                565                 570                 575     


Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp 
            580                 585                 590         


Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu 
        595                 600                 605             


Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile 
    610                 615                 620                 


Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Leu Leu Leu Val 
625                 630                 635                 640 


Ile Phe Gln Val Thr Gly Ile Ser Leu Leu Pro Pro Leu Gly Val Ala 
                645                 650                 655     


Ile Ser Val Ile Ile Ile Phe Tyr Cys Tyr Arg Val Asn Arg Gln 
            660                 665                 670     


<210> 48
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(15) 
<223> /note="This sequence may encompass 1-3 'Gly Gly Gly Gly Ser'
      repeating units"

<220> 
<221> source
<223> /note="See specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 48
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


