                         SEQUENCE LISTING

<110>  The Univeristy of Dundee
       Hay, Ronald
       Ibrahim, Adel
       Shen, Linnan
 
<120>  Protein Degradation

<130>  PG449359WO

<160>  41    

<170>  PatentIn version 3.5

<210>  1
<211>  187
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  1

Arg Lys Arg Arg Gly Gly Ala Ile Asn Ser Arg Gln Ala Gln Lys Arg 
1               5                   10                  15      


Thr Arg Glu Ala Thr Ser Thr Pro Glu Ile Ser Leu Glu Ala Glu Pro 
            20                  25                  30          


Ile Glu Leu Val Glu Thr Ala Gly Asp Glu Ile Val Asp Leu Thr Cys 
        35                  40                  45              


Glu Ser Leu Glu Pro Val Val Val Asp Leu Thr His Asn Asp Ser Val 
    50                  55                  60                  


Val Ile Val Asp Glu Arg Arg Arg Pro Arg Arg Asn Ala Arg Arg Leu 
65                  70                  75                  80  


Pro Gln Asp His Ala Asp Ser Cys Val Val Ser Ser Asp Asp Glu Glu 
                85                  90                  95      


Leu Ser Arg Asp Arg Asp Val Tyr Val Thr Thr His Thr Pro Arg Asn 
            100                 105                 110         


Ala Arg Asp Glu Gly Ala Thr Gly Leu Arg Pro Ser Gly Thr Val Ser 
        115                 120                 125             


Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Val Gln Asn Gly Arg 
    130                 135                 140                 


Leu Ile Val Ser Thr Glu Cys Gly His Val Phe Cys Ser Gln Cys Leu 
145                 150                 155                 160 


Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro Thr Cys Arg Lys Lys 
                165                 170                 175     


Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
            180                 185         


<210>  2
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  2

Arg Pro Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser 
1               5                   10                  15      


Glu Ile Val Gln Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His 
            20                  25                  30          


Val Phe Cys Ser Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile 
    50                  55                  60                  


Tyr Ile 
65      


<210>  3
<211>  187
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  3

Arg Lys Arg Arg Gly Gly Thr Val Asn Ser Arg Gln Thr Gln Lys Arg 
1               5                   10                  15      


Thr Arg Glu Thr Thr Ser Thr Pro Glu Val Ser Leu Glu Thr Glu Pro 
            20                  25                  30          


Ile Glu Leu Val Glu Thr Val Gly Asp Glu Ile Val Asp Leu Thr Cys 
        35                  40                  45              


Glu Ser Leu Glu Pro Val Val Val Asp Leu Thr His Asn Asp Ser Val 
    50                  55                  60                  


Val Ile Val Glu Glu Arg Arg Arg Pro Arg Arg Asn Gly Arg Arg Leu 
65                  70                  75                  80  


Arg Gln Asp His Ala Asp Ser Cys Val Val Ser Ser Asp Gly Glu Glu 
                85                  90                  95      


Leu Ser Arg Asp Lys Asp Val Tyr Val Thr Thr His Thr Pro Arg Ser 
            100                 105                 110         


Thr Lys Asp Asp Gly Ala Thr Gly Pro Arg Pro Ser Gly Thr Val Ser 
        115                 120                 125             


Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Val Gln Asn Gly Arg 
    130                 135                 140                 


Leu Ile Val Ser Thr Glu Cys Gly His Val Phe Cys Ser Gln Cys Leu 
145                 150                 155                 160 


Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro Thr Cys Arg Lys Lys 
                165                 170                 175     


Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
            180                 185         


<210>  4
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  4

Arg Pro Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser 
1               5                   10                  15      


Glu Ile Val Gln Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His 
            20                  25                  30          


Val Phe Cys Ser Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile 
    50                  55                  60                  


Tyr Ile 
65      


<210>  5
<211>  189
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  5

Arg Lys Arg Arg Gly Gly Ser Ala Asn Ser Arg Gln Ala Gln Lys Arg 
1               5                   10                  15      


Ser Arg Leu Ile Ala Ser Thr Thr Glu Met Ala Ser Glu Gly Glu Pro 
            20                  25                  30          


Ile Glu Leu Glu Glu Ser Ala Gly Glu Glu Val Val Asp Leu Thr Cys 
        35                  40                  45              


Glu Ser Ser Asp Pro Val Val Val Asp Leu Thr His Asn Asp Ser Ile 
    50                  55                  60                  


Val Ile Val Glu Glu Asn Gln Gln Arg Arg Arg Asn Leu Arg Leu Arg 
65                  70                  75                  80  


Gly Gln Arg Gln Ser Asp Ser Cys Val Leu Ser Ser Asp Asp Glu Asp 
                85                  90                  95      


Glu Thr Arg Asp Asn Asp Val Tyr Val Thr Asp Lys Val Ser Arg Glu 
            100                 105                 110         


Leu Gly Pro Leu Glu Asp Glu Thr Ala Ser Ser Lys Pro Ser Gly Thr 
        115                 120                 125             


Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Val Gln Ser 
    130                 135                 140                 


Gly Arg Leu Ile Val Ser Thr Lys Cys Gly His Val Phe Cys Ser Gln 
145                 150                 155                 160 


Cys Leu Arg Gly Ser Leu Arg Asn Ala Asn Ser Cys Pro Thr Cys Arg 
                165                 170                 175     


Lys Lys Leu Thr His Arg Gln Tyr His Pro Ile Tyr Ile 
            180                 185                 


<210>  6
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  6

Lys Pro Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser 
1               5                   10                  15      


Glu Ile Val Gln Ser Gly Arg Leu Ile Val Ser Thr Lys Cys Gly His 
            20                  25                  30          


Val Phe Cys Ser Gln Cys Leu Arg Gly Ser Leu Arg Asn Ala Asn Ser 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Leu Thr His Arg Gln Tyr His Pro Ile 
    50                  55                  60                  


Tyr Ile 
65      


<210>  7
<211>  186
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  7

Arg Lys Arg Arg Ser Gly Thr Thr Asn Ser Arg Gln Ala Gln Lys Arg 
1               5                   10                  15      


Glu Arg Leu Val Gly Pro Thr Ser Asp Met Thr Ser Glu Thr Glu Pro 
            20                  25                  30          


Ile Glu Leu Val Glu Ser Ala Gly Glu Glu Val Val Asp Leu Thr Cys 
        35                  40                  45              


Glu Ser Thr Glu Pro Val Val Val Asp Leu Thr His Asn Asp Pro Val 
    50                  55                  60                  


Val Phe Ile Glu Glu Asn Arg Arg Gln Arg Arg Asn Pro Arg Ile Ser 
65                  70                  75                  80  


Arg Gly Gln Pro Asp Ser Cys Val Leu Ser Ser Asp Asp Glu Glu Ile 
                85                  90                  95      


Arg Asp Asn Asp Val Tyr Val Thr Thr Glu Asn Pro Ser Arg Glu Ser 
            100                 105                 110         


Pro Asp Pro Ala Gly Phe Gly Glu Lys Pro Ser Gly Thr Val Ser Cys 
        115                 120                 125             


Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile Leu Gln Ser Gly Arg Leu 
    130                 135                 140                 


Ile Val Ser Thr Lys Cys Gly His Val Phe Cys Ser Gln Cys Leu Arg 
145                 150                 155                 160 


Asp Ala Leu Arg Asn Ala Ser Ser Cys Pro Thr Cys Arg Lys Lys Leu 
                165                 170                 175     


Asn Gln Lys Gln Tyr His Pro Ile Tyr Ile 
            180                 185     


<210>  8
<211>  65
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  8

Pro Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu 
1               5                   10                  15      


Ile Leu Gln Ser Gly Arg Leu Ile Val Ser Thr Lys Cys Gly His Val 
            20                  25                  30          


Phe Cys Ser Gln Cys Leu Arg Asp Ala Leu Arg Asn Ala Ser Ser Cys 
        35                  40                  45              


Pro Thr Cys Arg Lys Lys Leu Asn Gln Lys Gln Tyr His Pro Ile Tyr 
    50                  55                  60                  


Ile 
65  


<210>  9
<211>  181
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  9

Gly Ser Met Val Asn Ser Arg Gln Ala Arg Glu Phe His Thr Ala Gly 
1               5                   10                  15      


Glu Arg Gly Pro Thr Pro Gln Thr Val Leu Glu Ala Glu Leu Ile Glu 
            20                  25                  30          


Leu Gly Glu Ser Asp Glu Val Val Asp Leu Thr Cys Glu Ser Leu Glu 
        35                  40                  45              


Pro Ala Val Ile Asp Leu Thr His Gln Asp Cys Val Val Ile Thr Glu 
    50                  55                  60                  


Glu Arg Arg Arg Pro Arg Gly Asn Thr Arg Ser Leu Gln Gly Gln Thr 
65                  70                  75                  80  


Gly Ser Cys Val Val Ser Ser Asp Lys Glu Leu Met Arg Asp Arg Asp 
                85                  90                  95      


Val Tyr Val Thr His Ser Ala Tyr His Asn Ala Leu Glu Glu Glu Thr 
            100                 105                 110         


Leu Ser Cys Thr Leu Pro Gly Tyr Ile Gln Cys Arg Ile Cys Met Asp 
        115                 120                 125             


Gly Tyr Ser Glu Ile Glu Leu Ser Arg Arg His Ile Tyr Ser Thr Asp 
    130                 135                 140                 


Cys Gly His Ile Phe Cys Ser Gln Cys Leu Cys Thr Ser Leu Lys Tyr 
145                 150                 155                 160 


Thr Lys Thr Cys Pro Val Cys Leu Lys Lys Ile Gly Cys Arg Gln Tyr 
                165                 170                 175     


His Arg Ile Tyr Leu 
            180     


<210>  10
<211>  65
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  10

Leu Pro Gly Tyr Ile Gln Cys Arg Ile Cys Met Asp Gly Tyr Ser Glu 
1               5                   10                  15      


Ile Glu Leu Ser Arg Arg His Ile Tyr Ser Thr Asp Cys Gly His Ile 
            20                  25                  30          


Phe Cys Ser Gln Cys Leu Cys Thr Ser Leu Lys Tyr Thr Lys Thr Cys 
        35                  40                  45              


Pro Val Cys Leu Lys Lys Ile Gly Cys Arg Gln Tyr His Arg Ile Tyr 
    50                  55                  60                  


Leu 
65  


<210>  11
<211>  183
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  11

Val Thr Gln Arg Lys Arg Arg Thr Ser Thr Thr Cys Ser Arg Arg Gly 
1               5                   10                  15      


Asn Ser Lys Arg Asn Arg Ala Gln Met Ser Gln Thr Val Met Glu Thr 
            20                  25                  30          


Ile Asp Val Leu Glu Asn Asp Arg Thr Asn Ser Glu Asp Val Val Asp 
        35                  40                  45              


Leu Thr Cys Glu Gly Ser Glu Pro Ala Val Val Asp Leu Thr Asn Asn 
    50                  55                  60                  


Asp Ser Ile Val Val Val Glu Asp Gly Val Gln Arg Arg Val Gly Pro 
65                  70                  75                  80  


Cys Thr Glu Ser Tyr Val Leu Ser Ser Asp Glu Glu Glu Glu Ser Ser 
                85                  90                  95      


Leu Arg Leu Val Tyr Val Thr Ser Pro Gly Leu Leu Ser Ser Leu Arg 
            100                 105                 110         


Asp Ser Ser Arg Ala Arg Ser Thr Gly Ala Ile Ser Cys Pro Val Cys 
        115                 120                 125             


Met Asp Val Tyr Ser Glu Ile Met Asp Ser Gly Arg Leu Met Val Ser 
    130                 135                 140                 


Thr Lys Cys Gly His Leu Phe Cys Ser Gln Cys Ile Arg Asp Ser Leu 
145                 150                 155                 160 


Ser Arg Ala His Ser Cys Pro Thr Cys Arg Lys Lys Leu Thr His Lys 
                165                 170                 175     


Gln Tyr His Pro Ile Tyr Ile 
            180             


<210>  12
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  12

Arg Ser Thr Gly Ala Ile Ser Cys Pro Val Cys Met Asp Val Tyr Ser 
1               5                   10                  15      


Glu Ile Met Asp Ser Gly Arg Leu Met Val Ser Thr Lys Cys Gly His 
            20                  25                  30          


Leu Phe Cys Ser Gln Cys Ile Arg Asp Ser Leu Ser Arg Ala His Ser 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Leu Thr His Lys Gln Tyr His Pro Ile 
    50                  55                  60                  


Tyr Ile 
65      


<210>  13
<211>  185
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  13

Arg Lys Arg Lys Gly Ala Glu Pro Gly His Ser Lys Ser Ser Lys Arg 
1               5                   10                  15      


Arg Ala Pro Gly Ser Thr Ala Ala Met Thr Ala Ala Thr Glu Pro Ile 
            20                  25                  30          


Glu Leu Glu Ser Gly Glu Glu Val Val Asp Leu Thr Cys Glu Ser Thr 
        35                  40                  45              


Glu Pro Val Val Val Asp Leu Thr Asn Asn Asp Leu Ser Ile Asn Asp 
    50                  55                  60                  


Ser Val Val Ile Val Glu Asp Thr Pro Arg Gln Arg Arg Ala Leu Ser 
65                  70                  75                  80  


Arg Pro Ser Gln Gln Thr Thr Ser Cys Val Leu Ser Ser Asp Asp Glu 
                85                  90                  95      


Asp Ser Arg His Ala Asp His Phe Ala Ala Asn Lys Asp Ile Ser Ser 
            100                 105                 110         


Gln Ala Tyr Gly Ser Ser Arg Ser Ser Ser Gly Lys Val Ser Cys Pro 
        115                 120                 125             


Ile Cys Met Asp Ser Tyr Ser Glu Ile Val Gln Ser Gly Arg Leu Ile 
    130                 135                 140                 


Val Ser Thr Lys Cys Gly His Ile Phe Cys Ser Gln Cys Leu Arg Asp 
145                 150                 155                 160 


Ala Leu Lys Asn Ala Pro Ser Cys Pro Thr Cys Arg Lys Lys Leu Asn 
                165                 170                 175     


His Lys Gln Tyr His Pro Ile Tyr Val 
            180                 185 


<210>  14
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  14

Ser Ser Ser Gly Lys Val Ser Cys Pro Ile Cys Met Asp Ser Tyr Ser 
1               5                   10                  15      


Glu Ile Val Gln Ser Gly Arg Leu Ile Val Ser Thr Lys Cys Gly His 
            20                  25                  30          


Ile Phe Cys Ser Gln Cys Leu Arg Asp Ala Leu Lys Asn Ala Pro Ser 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Leu Asn His Lys Gln Tyr His Pro Ile 
    50                  55                  60                  


Tyr Val 
65      


<210>  15
<211>  185
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  15

Arg Lys Arg Lys Gly Ala Glu Pro Gly Leu Ser Lys Ser Arg Lys Arg 
1               5                   10                  15      


Arg Ala Pro Gly Ser Thr Ala Thr Met Ala Ala Glu Thr Glu Ala Ile 
            20                  25                  30          


Glu Leu Glu Ser Gly Glu Glu Val Val Asp Leu Thr Cys Glu Ser Thr 
        35                  40                  45              


Glu Pro Val Val Val Asp Leu Thr Asn Asn Asp Leu Ser Ile Asn Asp 
    50                  55                  60                  


Ser Val Val Ile Val Glu Asp Thr Pro Arg Gln Arg Arg Thr Val Ser 
65                  70                  75                  80  


Arg Thr Ser His Gln Thr Ser Ser Cys Val Leu Ser Ser Asp Asp Glu 
                85                  90                  95      


Gly Ser Arg Asp Thr Glu Leu Phe Ala Thr Asn Lys Asp Ile Ser Ser 
            100                 105                 110         


Pro Gly Tyr Gly Ser Ser Arg Ser Ser Ser Gly Lys Val Ser Cys Pro 
        115                 120                 125             


Ile Cys Met Asp Ser Tyr Ser Glu Ile Val Gln Ser Arg Arg Leu Ile 
    130                 135                 140                 


Val Ser Thr Lys Cys Gly His Ile Phe Cys Ser Gln Cys Leu Arg Asp 
145                 150                 155                 160 


Ala Leu Lys Asn Ala Leu Ser Cys Pro Thr Cys Arg Lys Lys Leu Asn 
                165                 170                 175     


Asn Lys Gln Tyr His Pro Ile Tyr Val 
            180                 185 


<210>  16
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  16

Ser Ser Ser Gly Lys Val Ser Cys Pro Ile Cys Met Asp Ser Tyr Ser 
1               5                   10                  15      


Glu Ile Val Gln Ser Arg Arg Leu Ile Val Ser Thr Lys Cys Gly His 
            20                  25                  30          


Ile Phe Cys Ser Gln Cys Leu Arg Asp Ala Leu Lys Asn Ala Leu Ser 
        35                  40                  45              


Cys Pro Thr Cys Arg Lys Lys Leu Asn Asn Lys Gln Tyr His Pro Ile 
    50                  55                  60                  


Tyr Val 
65      


<210>  17
<211>  176
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  17

Arg Glu Gly Gly Pro Thr Pro Asn Ile Ala Leu Asp Ala Glu Leu Ile 
1               5                   10                  15      


Glu Leu Gly Glu Ser Asp Glu Val Val Asp Leu Thr Cys Glu Ser Leu 
            20                  25                  30          


Ala Pro Val Val Ile Asp Leu Thr His Arg Asp Ser Val Val Ile Ile 
        35                  40                  45              


Glu Gln Arg Arg Arg Pro Arg Ala Asn Thr Arg Pro Leu Gln Asp His 
    50                  55                  60                  


Thr Gly Ser Cys Val Val Asn Asn Asp Glu Glu Gly Val Lys Arg Asp 
65                  70                  75                  80  


Arg Asp Val Ser Thr Asn Pro Ser Ser Asn Ile Asp Pro Gly Asn Tyr 
                85                  90                  95      


Val Glu Met Asn Asp Ser Ile Thr His Leu Pro Ser Lys Val Val Ile 
            100                 105                 110         


Gln Asp Ile Thr Met Glu Leu His Cys Pro Leu Cys Asn Asp Trp Phe 
        115                 120                 125             


Arg Asp Pro Leu Met Leu Ser Cys Gly His Asn Phe Cys Glu Ala Cys 
    130                 135                 140                 


Ile Gln Asp Phe Trp Arg Leu Gln Ala Lys Glu Thr Phe Cys Pro Glu 
145                 150                 155                 160 


Cys Lys Met Leu Cys Gln Tyr Asn Asn Cys Thr Phe Asn Pro Val Leu 
                165                 170                 175     


<210>  18
<211>  194
<212>  PRT
<213>  Rattus norvegicus

<400>  18

Met Ser Thr Arg Asn Pro Gln Arg Lys Arg Arg Gly Gly Ala Val Asn 
1               5                   10                  15      


Ser Arg Gln Thr Gln Lys Arg Thr Arg Glu Thr Thr Ser Thr Pro Glu 
            20                  25                  30          


Ile Ser Leu Glu Ala Glu Pro Ile Glu Leu Val Glu Thr Val Gly Asp 
        35                  40                  45              


Glu Ile Val Asp Leu Thr Cys Glu Ser Leu Glu Pro Val Val Val Asp 
    50                  55                  60                  


Leu Thr His Asn Asp Ser Val Val Ile Val Glu Glu Arg Arg Arg Pro 
65                  70                  75                  80  


Arg Arg Asn Gly Arg Arg Leu Arg Gln Asp His Ala Asp Ser Cys Val 
                85                  90                  95      


Val Ser Ser Asp Asp Glu Glu Leu Ser Lys Asp Lys Asp Val Tyr Val 
            100                 105                 110         


Thr Thr His Thr Pro Arg Ser Thr Lys Asp Glu Gly Thr Thr Gly Leu 
        115                 120                 125             


Arg Pro Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser 
    130                 135                 140                 


Glu Ile Val Gln Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His 
145                 150                 155                 160 


Val Phe Cys Ser Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr 
                165                 170                 175     


Cys Pro Thr Cys Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile 
            180                 185                 190         


Tyr Ile 
        


<210>  19
<211>  120
<212>  PRT
<213>  Rattus norvegicus

<400>  19

Glu Glu Arg Arg Arg Pro Arg Arg Asn Gly Arg Arg Leu Arg Gln Asp 
1               5                   10                  15      


His Ala Asp Ser Cys Val Val Ser Ser Asp Asp Glu Glu Leu Ser Lys 
            20                  25                  30          


Asp Lys Asp Val Tyr Val Thr Thr His Thr Pro Arg Ser Thr Lys Asp 
        35                  40                  45              


Glu Gly Thr Thr Gly Leu Arg Pro Ser Gly Thr Val Ser Cys Pro Ile 
    50                  55                  60                  


Cys Met Asp Gly Tyr Ser Glu Ile Val Gln Asn Gly Arg Leu Ile Val 
65                  70                  75                  80  


Ser Thr Glu Cys Gly His Val Phe Cys Ser Gln Cys Leu Arg Asp Ser 
                85                  90                  95      


Leu Lys Asn Ala Asn Thr Cys Pro Thr Cys Arg Lys Lys Ile Asn His 
            100                 105                 110         


Lys Arg Tyr His Pro Ile Tyr Ile 
        115                 120 


<210>  20
<211>  64
<212>  PRT
<213>  Rattus norvegicus

<400>  20

Ser Gly Thr Val Ser Cys Pro Ile Cys Met Asp Gly Tyr Ser Glu Ile 
1               5                   10                  15      


Val Gln Asn Gly Arg Leu Ile Val Ser Thr Glu Cys Gly His Val Phe 
            20                  25                  30          


Cys Ser Gln Cys Leu Arg Asp Ser Leu Lys Asn Ala Asn Thr Cys Pro 
        35                  40                  45              


Thr Cys Arg Lys Lys Ile Asn His Lys Arg Tyr His Pro Ile Tyr Ile 
    50                  55                  60                  


<210>  21
<211>  61
<212>  PRT
<213>  Unknown

<220>
<223>  RING domain

<400>  21

Gln Lys Glu Glu Leu Tyr Lys Cys Pro Ile Cys Met Asp Ser Val Ser 
1               5                   10                  15      


Lys Arg Glu Pro Val Ser Thr Lys Cys Gly His Val Phe Cys Arg Glu 
            20                  25                  30          


Cys Ile Glu Thr Ala Ile Arg Ala Thr His Lys Cys Pro Ile Cys Asn 
        35                  40                  45              


Lys Lys Leu Thr Ala Arg Gln Phe Phe Arg Ile Tyr Leu 
    50                  55                  60      


<210>  22
<211>  62
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  22

Pro Thr Pro Ala Ser Val Asn Cys Pro Ile Cys Phe Glu Ser Val Tyr 
1               5                   10                  15      


Arg Arg Gln Ala Ala Ser Thr Ile Cys Gly His Leu Phe Cys Asn Ala 
            20                  25                  30          


Cys Ile Thr Ala Glu Met Arg Ile Arg Lys Lys Cys Pro Leu Cys Lys 
        35                  40                  45              


His Pro Leu Lys Trp Gln Gln Val His Pro Ile Tyr Phe Asn 
    50                  55                  60          


<210>  23
<211>  63
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  23

Val Glu Glu Pro Lys Phe Ser Cys Pro Ile Cys Leu Cys Pro Phe Thr 
1               5                   10                  15      


Gln Glu Val Ser Thr Lys Cys Gly His Ile Phe Cys Lys Lys Cys Ile 
            20                  25                  30          


Lys Asn Ala Leu Ser Leu Gln Ala Lys Cys Pro Thr Cys Arg Lys Lys 
        35                  40                  45              


Ile Thr Val Lys Asp Leu Ile Arg Val Phe Leu Pro Thr Thr Arg 
    50                  55                  60              


<210>  24
<211>  64
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  24

Gln Arg Leu Ala Asp Tyr Lys Cys Val Ile Cys Leu Asp Ser Pro Glu 
1               5                   10                  15      


Asn Leu Ser Cys Thr Pro Cys Gly His Ile Phe Cys Asn Phe Cys Ile 
            20                  25                  30          


Leu Ser Ala Leu Gly Thr Thr Ala Ala Thr Gln Lys Cys Pro Val Cys 
        35                  40                  45              


Arg Arg Lys Val His Pro Asn Lys Val Ile Cys Leu Glu Met Met Leu 
    50                  55                  60                  


<210>  25
<211>  65
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  25

Gly Ala Ala Lys Asp Tyr Arg Cys Pro Ile Cys Phe Glu Pro Pro Glu 
1               5                   10                  15      


Thr Ala Leu Met Thr Leu Cys Gly His Val Phe Cys Cys Pro Cys Leu 
            20                  25                  30          


Phe Gln Met Val Asn Ser Ser Arg Thr Cys Arg Gln Phe Gly His Cys 
        35                  40                  45              


Ala Leu Cys Arg Ser Lys Val Tyr Leu Lys Asp Val Arg Leu Ile Ile 
    50                  55                  60                  


Leu 
65  


<210>  26
<211>  65
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  26

Thr Leu Glu Asp Ile Pro Val Cys Cys Leu Cys Gly Ala Glu Leu Gly 
1               5                   10                  15      


Leu Ser Lys Arg Thr Phe Ile Ala Ser Cys Gly His Ala Phe Cys Gly 
            20                  25                  30          


Arg Cys Phe Ala Arg Ile Asp Tyr Gly Pro Lys Leu Cys Pro Ala Asp 
        35                  40                  45              


Ser Cys Lys Lys Leu Ile Arg Ser Arg Gly Arg Leu Lys Glu Val Tyr 
    50                  55                  60                  


Phe 
65  


<210>  27
<211>  66
<212>  PRT
<213>  Unknown

<220>
<223>  RING Domain

<400>  27

His Pro His Asn Asn Ile Ala Cys Ala Lys Cys Gly Asn Glu Leu Val 
1               5                   10                  15      


Ser Asp Glu Lys Lys Ser Ile Phe Ala Ala Lys Cys Gly His Leu Phe 
            20                  25                  30          


Cys Ser Thr Cys Ala Lys Glu Leu Arg Lys Lys Thr Val Pro Cys Pro 
        35                  40                  45              


Val Gln His Cys Arg Lys Arg Ile Thr Lys Lys Phe Ile Phe Pro Leu 
    50                  55                  60                  


Tyr Leu 
65      


<210>  28
<211>  520
<212>  PRT
<213>  Unknown

<220>
<223>  U-box domain

<400>  28

Met Gly Lys Arg Gln His Gln Lys Asp Lys Met Tyr Ile Thr Cys Ala 
1               5                   10                  15      


Glu Tyr Thr His Phe Tyr Gly Gly Lys Lys Pro Asp Leu Pro Gln Thr 
            20                  25                  30          


Asn Phe Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro 
        35                  40                  45              


Phe Val Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu 
    50                  55                  60                  


Asn Ile Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly 
65                  70                  75                  80  


Glu Lys Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn 
                85                  90                  95      


Ser Glu Gly Lys Tyr His Cys Pro Val Leu Phe Thr Val Phe Thr Asn 
            100                 105                 110         


Asn Thr His Ile Val Ala Val Arg Thr Thr Gly Asn Val Tyr Ala Tyr 
        115                 120                 125             


Glu Ala Val Glu Gln Leu Asn Ile Lys Ala Lys Asn Phe Arg Asp Leu 
    130                 135                 140                 


Leu Thr Asp Glu Pro Phe Ser Arg Gln Asp Ile Ile Thr Leu Gln Asp 
145                 150                 155                 160 


Pro Thr Asn Leu Asp Lys Phe Asn Val Ser Asn Phe Tyr His Val Lys 
                165                 170                 175     


Asn Asn Met Lys Ile Ile Asp Pro Asp Glu Glu Lys Ala Lys Gln Asp 
            180                 185                 190         


Pro Ser Tyr Tyr Leu Lys Asn Thr Asn Ala Glu Thr Arg Glu Thr Leu 
        195                 200                 205             


Gln Glu Leu Tyr Lys Glu Phe Lys Gly Asp Glu Ile Leu Ala Ala Thr 
    210                 215                 220                 


Met Lys Ala Pro Glu Lys Lys Lys Val Asp Lys Leu Asn Ala Ala His 
225                 230                 235                 240 


Tyr Ser Thr Gly Lys Val Ser Ala Ser Phe Thr Ser Thr Ala Met Val 
                245                 250                 255     


Pro Glu Thr Thr His Glu Ala Ala Ala Ile Asp Glu Asp Val Leu Arg 
            260                 265                 270         


Tyr Gln Phe Val Lys Lys Lys Gly Tyr Val Arg Leu His Thr Asn Lys 
        275                 280                 285             


Gly Asp Leu Asn Leu Glu Leu His Cys Asp Leu Thr Pro Lys Thr Cys 
    290                 295                 300                 


Glu Asn Phe Ile Arg Leu Cys Lys Lys His Tyr Tyr Asp Gly Thr Ile 
305                 310                 315                 320 


Phe His Arg Ser Ile Arg Asn Phe Val Ile Gln Gly Gly Asp Pro Thr 
                325                 330                 335     


Gly Thr Gly Thr Gly Gly Glu Ser Tyr Trp Gly Lys Pro Phe Lys Asp 
            340                 345                 350         


Glu Phe Arg Pro Asn Leu Ser His Thr Gly Arg Gly Ile Leu Ser Met 
        355                 360                 365             


Ala Asn Ser Gly Pro Asn Ser Asn Arg Ser Gln Phe Phe Ile Thr Phe 
    370                 375                 380                 


Arg Ser Cys Ala Tyr Leu Asp Lys Lys His Thr Ile Phe Gly Arg Val 
385                 390                 395                 400 


Val Gly Gly Phe Asp Val Leu Thr Ala Met Glu Asn Val Glu Ser Asp 
                405                 410                 415     


Pro Lys Thr Asp Arg Pro Lys Glu Glu Ile Arg Ile Asp Ala Thr Thr 
            420                 425                 430         


Val Phe Val Asp Pro Tyr Glu Glu Ala Asp Ala Gln Ile Ala Gln Glu 
        435                 440                 445             


Arg Lys Thr Gln Leu Lys Val Ala Pro Glu Thr Lys Val Lys Ser Ser 
    450                 455                 460                 


Gln Pro Gln Ala Gly Ser Gln Gly Pro Gln Thr Phe Arg Gln Gly Val 
465                 470                 475                 480 


Gly Lys Tyr Ile Asn Pro Ala Ala Thr Lys Arg Ala Ala Glu Glu Glu 
                485                 490                 495     


Pro Ser Thr Ser Ala Thr Val Pro Met Ser Lys Lys Lys Pro Ser Arg 
            500                 505                 510         


Gly Phe Gly Asp Phe Ser Ser Trp 
        515                 520 


<210>  29
<211>  74
<212>  PRT
<213>  Unknown

<220>
<223>  U-box domain

<400>  29

Arg Arg Leu Pro Phe Asp His Cys Ser Leu Ser Leu Gln Pro Phe Val 
1               5                   10                  15      


Tyr Pro Val Cys Thr Pro Asp Gly Ile Val Phe Asp Leu Leu Asn Ile 
            20                  25                  30          


Val Pro Trp Leu Lys Lys Tyr Gly Thr Asn Pro Ser Asn Gly Glu Lys 
        35                  40                  45              


Leu Asp Gly Arg Ser Leu Ile Lys Leu Asn Phe Ser Lys Asn Ser Glu 
    50                  55                  60                  


Gly Lys Tyr His Cys Pro Val Leu Phe Thr 
65                  70                  


<210>  30
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplexes

<400>  30
gaucacguca guuucauca                                                    19


<210>  31
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplexes

<400>  31
ugaguuacau ggacagucu                                                    19


<210>  32
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplexes

<400>  32
ccaacaguca guuucauga                                                    19


<210>  33
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA duplexes

<400>  33
gggauguacg ugauaugua                                                    19


<210>  34
<211>  19
<212>  PRT
<213>  Unknown

<220>
<223>  NEDD8

<400>  34

Thr Leu Thr Gly Lys Glu Ile Glu Ile Asp Ile Glu Pro Thr Asp Lys 
1               5                   10                  15      


Val Glu Arg 
            


<210>  35
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  NEDD8

<400>  35

Glu Ile Glu Ile Asp Ile Glu Pro Thr Asp Lys Val Glu Arg 
1               5                   10                  


<210>  36
<211>  17
<212>  PRT
<213>  Unknown

<220>
<223>  NEDD8

<400>  36

Ile Lys Glu Arg Val Glu Glu Lys Glu Gly Ile Pro Pro Gln Gln Gln 
1               5                   10                  15      


Arg 
    


<210>  37
<211>  13
<212>  PRT
<213>  Unknown

<220>
<223>  NEDD8

<400>  37

Val Glu Glu Lys Glu Gly Ile Pro Pro Gln Gln Gln Arg 
1               5                   10              


<210>  38
<211>  14
<212>  PRT
<213>  Unknown

<220>
<223>  NEDD8

<400>  38

Ile Leu Gly Gly Ser Val Leu His Leu Val Leu Ala Leu Arg 
1               5                   10                  


<210>  39
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  NEDP1

<400>  39

Leu Ala Phe Val Glu Glu Lys 
1               5           


<210>  40
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  NEDP1

<400>  40

Leu Glu Ala Phe Leu Gly Arg 
1               5           


<210>  41
<211>  12
<212>  PRT
<213>  Unknown

<220>
<223>  NEDP1

<400>  41

Gln Val Ala Glu Lys Leu Glu Ala Phe Leu Gly Arg 
1               5                   10          


