                         SEQUENCE LISTING

<110>  Micreos Human Health B.V.
 
<120>  A chimeric endolysin polypeptide

<130>  P6091162PCT

<150>  EP20170432.7
<151>  2020-04-20

<160>  83    

<170>  PatentIn version 3.5

<210>  1
<211>  145
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-Tw

<400>  1

Met Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn 
1               5                   10                  15      


Thr Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu 
            20                  25                  30          


Ala Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp 
        35                  40                  45              


Gly Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr 
    50                  55                  60                  


Val Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val 
65                  70                  75                  80  


Val Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val 
                85                  90                  95      


Thr Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile 
        115                 120                 125             


Arg Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe 
    130                 135                 140                 


Ala 
145 


<210>  2
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23-LST

<400>  2

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
    130                 135                 140 


<210>  3
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3b-2638

<400>  3

Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser 
1               5                   10                  15      


Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro 
            20                  25                  30          


Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile 
        35                  40                  45              


Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp 
    50                  55                  60                  


Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp 
65                  70                  75                  80  


Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
                85                  90                  


<210>  4
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_SH3b2638

<400>  4

Met Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn 
1               5                   10                  15      


Thr Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu 
            20                  25                  30          


Ala Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp 
        35                  40                  45              


Gly Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr 
    50                  55                  60                  


Val Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val 
65                  70                  75                  80  


Val Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val 
                85                  90                  95      


Thr Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile 
        115                 120                 125             


Arg Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe 
    130                 135                 140                 


Ala Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser 
145                 150                 155                 160 


Asp Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys 
                165                 170                 175     


Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu 
            180                 185                 190         


His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr 
        195                 200                 205             


Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly 
    210                 215                 220                 


Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp 
225                 230                 235                 240 


Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg 
                245                 250                 255     


Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile 
            260                 265                 270         


Lys 
    


<210>  5
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23LST_SH3b2638

<400>  5

Met Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn 
1               5                   10                  15      


Thr Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu 
            20                  25                  30          


Ala Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp 
        35                  40                  45              


Gly Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr 
    50                  55                  60                  


Val Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val 
65                  70                  75                  80  


Val Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val 
                85                  90                  95      


Thr Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile 
        115                 120                 125             


Arg Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe 
    130                 135                 140                 


Ala Thr Glu Ser Ser Val Lys Lys Lys Asp Thr Lys Lys Lys Pro Lys 
145                 150                 155                 160 


Pro Ser Asn Arg Asp Gly Ile Asn Lys Asp Lys Ala Ala Thr His Glu 
                165                 170                 175     


His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly 
            180                 185                 190         


Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly Val Asp Phe 
        195                 200                 205             


Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser Gly Lys Ile 
    210                 215                 220                 


Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln Ile Gly Leu 
225                 230                 235                 240 


Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His Leu Ser Lys 
                245                 250                 255     


Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln Ile Ile Gly 
            260                 265                 270         


Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu His Phe Gln 
        275                 280                 285             


Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp Pro Met Pro 
    290                 295                 300                 


Phe Leu Lys Ser Ala Gly Tyr Gly Gly Lys Leu Glu Val Ser Lys Ala 
305                 310                 315                 320 


Ala Thr Ile Lys Gln Ser Asp Val Lys Gln Glu Val Lys Lys Gln Glu 
                325                 330                 335     


Ala Lys Gln Ile Val Lys Ala Thr Asp Trp Lys Gln Asn Lys Asp Gly 
            340                 345                 350         


Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu 
        355                 360                 365             


Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala 
    370                 375                 380                 


Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys 
385                 390                 395                 400 


Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr 
                405                 410                 415     


Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly 
            420                 425                 430         


Lys Leu Trp Gly Glu Ile Lys 
        435                 


<210>  6
<211>  428
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPTw_SH3b2638

<400>  6

Met Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys 
1               5                   10                  15      


Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met 
            20                  25                  30          


His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala 
        35                  40                  45              


Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly 
    50                  55                  60                  


Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp 
65                  70                  75                  80  


Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys 
                85                  90                  95      


Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala 
            100                 105                 110         


Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr 
        115                 120                 125             


Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Lys Ala 
    130                 135                 140                 


Gly Gly Thr Val Thr Pro Thr Pro Asn Thr Gly Met Lys Thr Leu Lys 
145                 150                 155                 160 


Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe 
                165                 170                 175     


Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile 
            180                 185                 190         


Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp 
        195                 200                 205             


Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr 
    210                 215                 220                 


Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly 
225                 230                 235                 240 


Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro 
                245                 250                 255     


Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly 
            260                 265                 270         


Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr 
        275                 280                 285             


Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala Gly Gly Lys Leu 
    290                 295                 300                 


Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp Val Lys Gln Glu 
305                 310                 315                 320 


Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala Thr Asp Trp Lys 
                325                 330                 335     


Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr 
            340                 345                 350         


Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr 
        355                 360                 365             


Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr 
    370                 375                 380                 


Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr 
385                 390                 395                 400 


Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys 
                405                 410                 415     


Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
            420                 425             


<210>  7
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPK

<400>  7

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys 
    130                 135         


<210>  8
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23-2638

<400>  8

Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser 
1               5                   10                  15      


Phe Thr Val Thr Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro 
            20                  25                  30          


Trp Thr Gly His Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile 
        35                  40                  45              


Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp 
    50                  55                  60                  


Glu Thr Phe Glu Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp 
65                  70                  75                  80  


Ala Lys Thr Gly Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
                85                  90                  


<210>  9
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3b-LST

<400>  9

Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser 
1               5                   10                  15      


Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg 
            20                  25                  30          


Ser Met Pro Gln Ser Gly Val Leu Lys Ala Gly Gln Thr Ile His Tyr 
        35                  40                  45              


Asp Glu Val Met Lys Gln Asp Gly His Val Trp Val Gly Tyr Thr Gly 
    50                  55                  60                  


Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser 
65                  70                  75                  80  


Thr Asn Thr Leu Gly Val Leu Trp Gly Thr Ile Lys 
                85                  90          


<210>  10
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3b-ALE1

<400>  10

Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser 
1               5                   10                  15      


Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg 
            20                  25                  30          


Ser Met Pro Gln Ser Gly Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr 
        35                  40                  45              


Asp Glu Val Met Lys Gln Asp Gly His Val Trp Val Gly Tyr Asn Thr 
    50                  55                  60                  


Asn Ser Gly Lys Arg Val Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser 
65                  70                  75                  80  


Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr Ile Lys 
                85                  90          


<210>  11
<211>  143
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-SEP

<400>  11

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys 
    130                 135                 140             


<210>  12
<211>  165
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-GH15

<400>  12

Met Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala 
1               5                   10                  15      


Lys Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr 
            20                  25                  30          


Asp Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly 
        35                  40                  45              


Tyr Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp 
    50                  55                  60                  


Leu Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile 
65                  70                  75                  80  


Lys Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser 
                85                  90                  95      


Thr Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr 
            100                 105                 110         


Gln Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser 
        115                 120                 125             


Thr Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys 
    130                 135                 140                 


Pro Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu 
145                 150                 155                 160 


Ile Pro Val Lys Ala 
                165 


<210>  13
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAP-K

<400>  13

Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys 
1               5                   10                  15      


Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp 
            20                  25                  30          


Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly 
        35                  40                  45              


Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly Val Pro 
    50                  55                  60                  


Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Thr 
65                  70                  75                  80  


Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr 
                85                  90                  95      


Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala 
            100                 105                 110         


Gln Tyr Ile Tyr Asp 
        115         


<210>  14
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23-ALE1

<400>  14

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly 
    130                 135                 140     


<210>  15
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw

<400>  15

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp 
    130                 135 


<210>  16
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-Tw C-terminal linker

<400>  16

Thr Glu Ser Ser Val Lys Lys Lys Asp Thr Lys Lys Lys Pro Lys Pro 
1               5                   10                  15      


Ser Asn Arg Asp Gly Ile Asn Lys Asp Lys 
            20                  25      


<210>  17
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23-LST C-terminal linker

<400>  17

Gly Lys Ala Gly Gly Thr Val Thr Pro Thr Pro Asn Thr Gly 
1               5                   10                  


<210>  18
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3b-2683 N-terminal linker

<400>  18

Gly Gly Lys Leu Glu Val Ser Lys Ala Ala Thr Ile Lys Gln Ser Asp 
1               5                   10                  15      


Val Lys Gln Glu Val Lys Lys Gln Glu Ala Lys Gln Ile Val Lys Ala 
            20                  25                  30          


Thr Asp 
        


<210>  19
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-SEP C-terminal linker

<400>  19

Phe Lys Lys Thr Val Lys Lys Glu Asp Asn Thr Leu Thr Lys Glu Lys 
1               5                   10                  15      


Asn Asn Lys Lys Thr Lys Gly Lys Lys Leu Lys Val Ser Thr Gln Arg 
            20                  25                  30          


<210>  20
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAP-GH15 C-terminal linker

<400>  20

Gly Thr Thr Val Lys Lys Glu Thr Ala Lys Lys Ser Ala Ser Lys Thr 
1               5                   10                  15      


Pro Ala Pro Lys Lys Lys Ala 
            20              


<210>  21
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAP-Tw N-terminal linker

<400>  21

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro 
        


<210>  22
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23-ALE1 C-terminal linker

<400>  22

Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
1               5                   10      


<210>  23
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SH3b-ALE-1 N-terminal Linker

<400>  23

Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
1               5                   10          


<210>  24
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23Ale1_SH3b2638

<400>  24

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
    210                 215                 220                 


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile 
                325                 330                 335     


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
            340                 345                 350         


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
        355                 360                 365             


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
    370                 375                 380                 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
385                 390                 395                 400 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
                405                 410                 415     


Leu Trp Gly Glu Ile Lys 
            420         


<210>  25
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23Ale1_SH3bAle1v

<400>  25

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
    210                 215                 220                 


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  26
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23Ale1_SH3bLST

<400>  26

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
    210                 215                 220                 


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  27
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23LST_SH3b2638

<400>  27

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
    210                 215                 220                 


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile 
                325                 330                 335     


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
            340                 345                 350         


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
        355                 360                 365             


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
    370                 375                 380                 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
385                 390                 395                 400 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
                405                 410                 415     


Leu Trp Gly Glu Ile Lys 
            420         


<210>  28
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23LST_SH3bAle1

<400>  28

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
    210                 215                 220                 


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  29
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPGH15_M23LST_SH3bLST

<400>  29

Ala Lys Thr Gln Ala Glu Ile Asn Lys Arg Leu Asp Ala Tyr Ala Lys 
1               5                   10                  15      


Gly Thr Val Asp Ser Pro Tyr Arg Ile Lys Lys Ala Thr Ser Tyr Asp 
            20                  25                  30          


Pro Ser Phe Gly Val Met Glu Ala Gly Ala Ile Asp Ala Asp Gly Tyr 
        35                  40                  45              


Tyr His Ala Gln Cys Gln Asp Leu Ile Thr Asp Tyr Val Leu Trp Leu 
    50                  55                  60                  


Thr Asp Asn Lys Val Arg Thr Trp Gly Asn Ala Lys Asp Gln Ile Lys 
65                  70                  75                  80  


Gln Ser Tyr Gly Thr Gly Phe Lys Ile His Glu Asn Lys Pro Ser Thr 
                85                  90                  95      


Val Pro Lys Lys Gly Trp Ile Ala Val Phe Thr Ser Gly Ser Tyr Gln 
            100                 105                 110         


Gln Trp Gly His Ile Gly Ile Val Tyr Asp Gly Gly Asn Thr Ser Thr 
        115                 120                 125             


Phe Thr Ile Leu Glu Gln Asn Trp Asn Gly Tyr Ala Asn Lys Lys Pro 
    130                 135                 140                 


Thr Lys Arg Val Asp Asn Tyr Tyr Gly Leu Thr His Phe Ile Glu Ile 
145                 150                 155                 160 


Pro Val Lys Ala Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly 
                165                 170                 175     


Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
            180                 185                 190         


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
        195                 200                 205             


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
    210                 215                 220                 


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
225                 230                 235                 240 


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
                245                 250                 255     


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
            260                 265                 270         


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
        275                 280                 285             


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
    290                 295                 300                 


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  30
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23Ale1_SH3b2638

<400>  30

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  31
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23Ale1_SH3bAle1

<400>  31

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  32
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23Ale1_SH3bLST

<400>  32

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  33
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23LST_SH3b2638

<400>  33

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  34
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23LST_SH3bAle1

<400>  34

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  35
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPSEP_M23LST_SH3bLST

<400>  35

Met Lys Thr Lys Lys Gln Ala Leu Lys Trp Ile Leu Asn Thr Ile Gly 
1               5                   10                  15      


Gln Gly Ile Asp Trp Asp Lys Met Tyr Gly Phe Gln Cys Met Asp Leu 
            20                  25                  30          


Val Val Ala Tyr Leu Tyr Tyr Val Thr Asp Gly Lys Ile Ala Met Trp 
        35                  40                  45              


Gly Asn Ala Ile Asp Ala Pro Lys Asn Asn Phe Lys Gly Thr Ala Lys 
    50                  55                  60                  


Val Ile Lys Asn Tyr Pro Ala Phe Arg Pro Glu Glu Gly Asp Ile Val 
65                  70                  75                  80  


Val Trp Ser Tyr Gly Asn Phe Ser Thr Tyr Gly His Ile Ala Val Val 
                85                  90                  95      


Ile Asp Gly Asp Pro Tyr Gly Asp Leu Gln Tyr Ile Thr Val Ala Glu 
            100                 105                 110         


Gln Asn Trp Asn Gly Leu Gly Leu Tyr Lys Gln Glu Val Thr Thr Lys 
        115                 120                 125             


Arg Ile His Asn Tyr Asp Gly Val Ser His Phe Ile Arg Pro Lys Phe 
    130                 135                 140                 


Lys Lys Thr Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  36
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23Ale1_SH3b2638

<400>  36

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  37
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23Ale1_SH3bAle1

<400>  37

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  38
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23Ale1_SH3bLST

<400>  38

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile Ser Asp 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly Asn Glu 
    210                 215                 220                 


Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  39
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23LST_SH3b2638

<400>  39

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  40
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23LST_ SH3bAle1

<400>  40

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  41
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CHAPTw_M23LST_SH3bLST

<400>  41

Lys Thr Leu Lys Gln Ala Glu Ser Tyr Ile Lys Ser Lys Val Asn Thr 
1               5                   10                  15      


Gly Thr Asp Phe Asp Gly Leu Tyr Gly Tyr Gln Cys Met Asp Leu Ala 
            20                  25                  30          


Val Asp Tyr Ile Tyr His Val Thr Asp Gly Lys Ile Arg Met Trp Gly 
        35                  40                  45              


Asn Ala Lys Asp Ala Ile Asn Asn Ser Phe Gly Gly Thr Ala Thr Val 
    50                  55                  60                  


Tyr Lys Asn Tyr Pro Ala Phe Arg Pro Lys Tyr Gly Asp Val Val Val 
65                  70                  75                  80  


Trp Thr Thr Gly Asn Phe Ala Thr Tyr Gly His Ile Ala Ile Val Thr 
                85                  90                  95      


Asn Pro Asp Pro Tyr Gly Asp Leu Gln Tyr Val Thr Val Leu Glu Gln 
            100                 105                 110         


Asn Trp Asn Gly Asn Gly Ile Tyr Lys Thr Glu Leu Ala Thr Ile Arg 
        115                 120                 125             


Thr His Asp Tyr Thr Gly Ile Thr His Phe Ile Arg Pro Asn Phe Ala 
    130                 135                 140                 


Thr Glu Ser Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Ala Ala 
145                 150                 155                 160 


Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys Gly Tyr 
                165                 170                 175     


Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His Tyr Gly 
            180                 185                 190         


Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile Ser Ser 
        195                 200                 205             


Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly Asn Gln 
    210                 215                 220                 


Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr Met His 
225                 230                 235                 240 


Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala Gly Gln 
                245                 250                 255     


Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro His Leu 
            260                 265                 270         


His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala Gln Asp 
        275                 280                 285             


Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  42
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23Ale1_SH3b2638

<400>  42

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro 
            180                 185                 190         


Val Arg Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Arg Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser 
            260                 265                 270         


Asn Asn Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn 
    290                 295                 300                 


Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr 
305                 310                 315                 320 


Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His 
                325                 330                 335     


Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu 
            340                 345                 350         


Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu 
        355                 360                 365             


Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly 
    370                 375                 380                 


Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390                 


<210>  43
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23Ale1_SH3bAle1

<400>  43

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro 
            180                 185                 190         


Val Arg Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Arg Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser 
            260                 265                 270         


Asn Asn Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys 
        355                 360                 365             


Arg Val Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu 
    370                 375                 380                 


Gly Pro Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  44
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23Ale1_SH3bLST

<400>  44

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro 
            180                 185                 190         


Val Arg Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Arg Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser 
            260                 265                 270         


Asn Asn Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln 
        355                 360                 365             


Arg Ile Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu 
    370                 375                 380                 


Gly Val Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  45
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23LST_SH3b2638

<400>  45

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro 
            180                 185                 190         


Val Lys Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Tyr Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser 
            260                 265                 270         


Asn Ser Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn 
    290                 295                 300                 


Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr 
305                 310                 315                 320 


Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His 
                325                 330                 335     


Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu 
            340                 345                 350         


Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu 
        355                 360                 365             


Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly 
    370                 375                 380                 


Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390                 


<210>  46
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23LST_SH3bAle1

<400>  46

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro 
            180                 185                 190         


Val Lys Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Tyr Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser 
            260                 265                 270         


Asn Ser Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys 
        355                 360                 365             


Arg Val Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu 
    370                 375                 380                 


Gly Pro Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  47
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPK_M23LST_SH3bLST

<400>  47

Ser Leu Lys Lys Tyr Asn Gly Lys Leu Pro Lys His Asp Pro Ser Phe 
1               5                   10                  15      


Val Gln Pro Gly Asn Arg His Tyr Lys Tyr Gln Cys Thr Trp Tyr Ala 
            20                  25                  30          


Tyr Asn Arg Arg Gly Gln Leu Gly Ile Pro Val Pro Leu Trp Gly Asp 
        35                  40                  45              


Ala Ala Asp Trp Ile Gly Gly Ala Lys Gly Ala Gly Tyr Gly Val Gly 
    50                  55                  60                  


Arg Thr Pro Lys Gln Gly Ala Cys Val Ile Trp Gln Arg Gly Val Gln 
65                  70                  75                  80  


Gly Gly Ser Pro Gln Tyr Gly His Val Ala Phe Val Glu Lys Val Leu 
                85                  90                  95      


Asp Gly Gly Lys Lys Ile Phe Ile Ser Glu His Asn Tyr Ala Thr Pro 
            100                 105                 110         


Asn Gly Tyr Gly Thr Arg Thr Ile Asp Met Ser Ser Ala Ile Gly Lys 
        115                 120                 125             


Asn Ala Gln Phe Ile Tyr Asp Lys Lys Ser Asn Ser Thr Ser Ser Ser 
    130                 135                 140                 


Asn Asn Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn 
145                 150                 155                 160 


Asn Tyr Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn 
                165                 170                 175     


Gly Gly Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro 
            180                 185                 190         


Val Lys Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn 
        195                 200                 205             


Tyr Gly Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His 
    210                 215                 220                 


Arg Gln Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp 
225                 230                 235                 240 


Tyr Val Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr 
                245                 250                 255     


Ser Thr Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser 
            260                 265                 270         


Asn Ser Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr 
        275                 280                 285             


Gly Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln 
        355                 360                 365             


Arg Ile Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu 
    370                 375                 380                 


Gly Val Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  48
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23Ale1_SH3b2638

<400>  48

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg 
            180                 185                 190         


Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp 
    290                 295                 300                 


Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro 
305                 310                 315                 320 


Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln 
                325                 330                 335     


Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln 
            340                 345                 350         


Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu 
        355                 360                 365             


Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val 
    370                 375                 380                 


Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390         


<210>  49
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23Ale1_SH3bAle1

<400>  49

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg 
            180                 185                 190         


Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  50
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23Ale1_SH3bLST

<400>  50

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Asn His Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg 
            180                 185                 190         


Ala Ile Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  51
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23LST_SH3b2638

<400>  51

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys 
            180                 185                 190         


Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp 
    290                 295                 300                 


Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro 
305                 310                 315                 320 


Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln 
                325                 330                 335     


Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln 
            340                 345                 350         


Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu 
        355                 360                 365             


Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val 
    370                 375                 380                 


Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390         


<210>  52
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23LST_SH3bAle1

<400>  52

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys 
            180                 185                 190         


Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  53
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  TCHAPTw_M23LST_SH3bLST

<400>  53

Gly Lys Glu Leu Pro Thr Pro Arg Asn Lys Thr Asp Thr Ser Trp Thr 
1               5                   10                  15      


Ala Pro Gly Asn Pro Asn Thr Gly Gln Trp Ala Arg Glu Cys Thr Trp 
            20                  25                  30          


Tyr Cys Tyr Asn Arg Arg Tyr Glu Leu Gly Leu Lys Ala Val Ala Tyr 
        35                  40                  45              


Gly Asp Ala Ala Asp Trp Ile Ala Gly Ala Arg Gly Ala Gly Ile Ser 
    50                  55                  60                  


Thr Gly Lys Glu Pro Lys Arg Gly Ala Val Ala Val Trp Ala Arg Gly 
65                  70                  75                  80  


Val Pro Gly Gly Ser Ala Gln Tyr Gly His Val Ala Phe Val Glu Lys 
                85                  90                  95      


Val Thr Asp Asp Gly Ile Tyr Val Ser Asp Tyr Asn Tyr Ala Ser Pro 
            100                 105                 110         


Lys Thr Tyr Gly Glu Arg Leu Tyr Lys Lys Gly Ser Pro Glu Tyr Arg 
        115                 120                 125             


Asn Ala Gln Tyr Ile Tyr Asp Ser Asn Ser Thr Ser Ser Ser Asn Asn 
    130                 135                 140                 


Asn Gly Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr 
145                 150                 155                 160 


Lys Lys Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly 
                165                 170                 175     


Met His Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys 
            180                 185                 190         


Ala Ile Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly 
        195                 200                 205             


Gly Gly Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln 
    210                 215                 220                 


Trp Tyr Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val 
225                 230                 235                 240 


Lys Ala Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr 
                245                 250                 255     


Ala Pro His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser 
            260                 265                 270         


Thr Ala Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  54
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPGH15_SH3b2638

<400>  54

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile 
                325                 330                 335     


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
            340                 345                 350         


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
        355                 360                 365             


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
    370                 375                 380                 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
385                 390                 395                 400 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
                405                 410                 415     


Leu Trp Gly Glu Ile Lys 
            420         


<210>  55
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPGH15_SH3bAle1

<400>  55

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  56
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPGH15_SH3bLST

<400>  56

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  57
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPSEP_SH3b2638

<400>  57

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  58
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPSEP_SH3bAle1

<400>  58

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  59
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPSEP_SH3bLST

<400>  59

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  60
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPTw_SH3b2638

<400>  60

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  61
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPTw_SH3bAle1

<400>  61

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  62
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_CHAPTw_SH3bLST

<400>  62

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  63
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPK_SH3b2638

<400>  63

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn 
    290                 295                 300                 


Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr 
305                 310                 315                 320 


Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His 
                325                 330                 335     


Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu 
            340                 345                 350         


Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu 
        355                 360                 365             


Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly 
    370                 375                 380                 


Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390                 


<210>  64
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPK_SH3bAle1

<400>  64

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys 
        355                 360                 365             


Arg Val Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu 
    370                 375                 380                 


Gly Pro Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  65
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPK_SH3bLST

<400>  65

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln 
        355                 360                 365             


Arg Ile Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu 
    370                 375                 380                 


Gly Val Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  66
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPTw_SH3b2638

<400>  66

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp 
    290                 295                 300                 


Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro 
305                 310                 315                 320 


Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln 
                325                 330                 335     


Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln 
            340                 345                 350         


Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu 
        355                 360                 365             


Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val 
    370                 375                 380                 


Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390         


<210>  67
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPTw_SH3bAle1

<400>  67

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  68
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23Ale1_TCHAPTw_SH3bLST

<400>  68

Ala Ala Gln Ser Asn His Ser Ala Ser Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Asn His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Val Gly Thr Pro Val Arg Ala Ile 
        35                  40                  45              


Ser Asp Gly Lys Ile Val Glu Ala Gly Trp Thr Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Glu Ile Gly Leu Val Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Phe Asn Val Lys Val Gly Asp Arg Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Thr Asn Ser Phe Ser Asn Asn Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  69
<211>  422
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPGH15_SH3b2638

<400>  69

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile 
                325                 330                 335     


Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly 
            340                 345                 350         


Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly 
        355                 360                 365             


Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe 
    370                 375                 380                 


Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val 
385                 390                 395                 400 


Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys 
                405                 410                 415     


Leu Trp Gly Glu Ile Lys 
            420         


<210>  70
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPGH15_SH3bAle1

<400>  70

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  71
<211>  420
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPGH15_SH3bLST

<400>  71

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ala Lys Thr Gln Ala Glu Ile Asn 
145                 150                 155                 160 


Lys Arg Leu Asp Ala Tyr Ala Lys Gly Thr Val Asp Ser Pro Tyr Arg 
                165                 170                 175     


Ile Lys Lys Ala Thr Ser Tyr Asp Pro Ser Phe Gly Val Met Glu Ala 
            180                 185                 190         


Gly Ala Ile Asp Ala Asp Gly Tyr Tyr His Ala Gln Cys Gln Asp Leu 
        195                 200                 205             


Ile Thr Asp Tyr Val Leu Trp Leu Thr Asp Asn Lys Val Arg Thr Trp 
    210                 215                 220                 


Gly Asn Ala Lys Asp Gln Ile Lys Gln Ser Tyr Gly Thr Gly Phe Lys 
225                 230                 235                 240 


Ile His Glu Asn Lys Pro Ser Thr Val Pro Lys Lys Gly Trp Ile Ala 
                245                 250                 255     


Val Phe Thr Ser Gly Ser Tyr Gln Gln Trp Gly His Ile Gly Ile Val 
            260                 265                 270         


Tyr Asp Gly Gly Asn Thr Ser Thr Phe Thr Ile Leu Glu Gln Asn Trp 
        275                 280                 285             


Asn Gly Tyr Ala Asn Lys Lys Pro Thr Lys Arg Val Asp Asn Tyr Tyr 
    290                 295                 300                 


Gly Leu Thr His Phe Ile Glu Ile Pro Val Lys Ala Gly Ser Asn Ser 
305                 310                 315                 320 


Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr 
                325                 330                 335     


Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile 
            340                 345                 350         


Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu 
        355                 360                 365             


Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly 
    370                 375                 380                 


His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu 
385                 390                 395                 400 


Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp 
                405                 410                 415     


Gly Thr Ile Lys 
            420 


<210>  72
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPSEP_SH3b2638

<400>  72

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  73
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPSEP_SH3bAle1

<400>  73

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  74
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPSEP_SH3bLST

<400>  74

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Met Lys Thr Lys Lys Gln Ala Leu 
145                 150                 155                 160 


Lys Trp Ile Leu Asn Thr Ile Gly Gln Gly Ile Asp Trp Asp Lys Met 
                165                 170                 175     


Tyr Gly Phe Gln Cys Met Asp Leu Val Val Ala Tyr Leu Tyr Tyr Val 
            180                 185                 190         


Thr Asp Gly Lys Ile Ala Met Trp Gly Asn Ala Ile Asp Ala Pro Lys 
        195                 200                 205             


Asn Asn Phe Lys Gly Thr Ala Lys Val Ile Lys Asn Tyr Pro Ala Phe 
    210                 215                 220                 


Arg Pro Glu Glu Gly Asp Ile Val Val Trp Ser Tyr Gly Asn Phe Ser 
225                 230                 235                 240 


Thr Tyr Gly His Ile Ala Val Val Ile Asp Gly Asp Pro Tyr Gly Asp 
                245                 250                 255     


Leu Gln Tyr Ile Thr Val Ala Glu Gln Asn Trp Asn Gly Leu Gly Leu 
            260                 265                 270         


Tyr Lys Gln Glu Val Thr Thr Lys Arg Ile His Asn Tyr Asp Gly Val 
        275                 280                 285             


Ser His Phe Ile Arg Pro Lys Phe Lys Lys Thr Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  75
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPTw__SH3bAle1

<400>  75

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Arg Lys 
            340                 345                 350         


Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  76
<211>  404
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPTw_SH3b2638

<400>  76

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp Gly Ile Trp Tyr 
305                 310                 315                 320 


Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro Glu Gly Ile Ile 
                325                 330                 335     


Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln Ala Gly Val Leu 
            340                 345                 350         


Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln Lys Phe Asp Gly 
        355                 360                 365             


His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu Thr Val Tyr Met 
    370                 375                 380                 


Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val Gly Lys Leu Trp 
385                 390                 395                 400 


Gly Glu Ile Lys 
                


<210>  77
<211>  402
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_CHAPTw_SH3bLST

<400>  77

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Lys Thr Leu Lys Gln Ala Glu Ser 
145                 150                 155                 160 


Tyr Ile Lys Ser Lys Val Asn Thr Gly Thr Asp Phe Asp Gly Leu Tyr 
                165                 170                 175     


Gly Tyr Gln Cys Met Asp Leu Ala Val Asp Tyr Ile Tyr His Val Thr 
            180                 185                 190         


Asp Gly Lys Ile Arg Met Trp Gly Asn Ala Lys Asp Ala Ile Asn Asn 
        195                 200                 205             


Ser Phe Gly Gly Thr Ala Thr Val Tyr Lys Asn Tyr Pro Ala Phe Arg 
    210                 215                 220                 


Pro Lys Tyr Gly Asp Val Val Val Trp Thr Thr Gly Asn Phe Ala Thr 
225                 230                 235                 240 


Tyr Gly His Ile Ala Ile Val Thr Asn Pro Asp Pro Tyr Gly Asp Leu 
                245                 250                 255     


Gln Tyr Val Thr Val Leu Glu Gln Asn Trp Asn Gly Asn Gly Ile Tyr 
            260                 265                 270         


Lys Thr Glu Leu Ala Thr Ile Arg Thr His Asp Tyr Thr Gly Ile Thr 
        275                 280                 285             


His Phe Ile Arg Pro Asn Phe Ala Thr Glu Ser Ser Asn Ser Thr Ser 
    290                 295                 300                 


Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr Gly Thr Leu Tyr 
305                 310                 315                 320 


Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp Ile Ile Thr Arg 
                325                 330                 335     


Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly Val Leu Lys Ala 
            340                 345                 350         


Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln Asp Gly His Val 
        355                 360                 365             


Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile Tyr Leu Pro Val 
    370                 375                 380                 


Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val Leu Trp Gly Thr 
385                 390                 395                 400 


Ile Lys 
        


<210>  78
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPK_SH3b2638

<400>  78

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn 
    290                 295                 300                 


Lys Asp Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr 
305                 310                 315                 320 


Ala Pro Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His 
                325                 330                 335     


Pro Gln Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu 
            340                 345                 350         


Val Gln Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu 
        355                 360                 365             


Gly Glu Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly 
    370                 375                 380                 


Lys Val Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390                 


<210>  79
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPK_SH3bAle1

<400>  79

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys 
        355                 360                 365             


Arg Val Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu 
    370                 375                 380                 


Gly Pro Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  80
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPK_SH3bLST

<400>  80

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Ser Leu Lys Lys Tyr Asn Gly Lys 
145                 150                 155                 160 


Leu Pro Lys His Asp Pro Ser Phe Val Gln Pro Gly Asn Arg His Tyr 
                165                 170                 175     


Lys Tyr Gln Cys Thr Trp Tyr Ala Tyr Asn Arg Arg Gly Gln Leu Gly 
            180                 185                 190         


Ile Pro Val Pro Leu Trp Gly Asp Ala Ala Asp Trp Ile Gly Gly Ala 
        195                 200                 205             


Lys Gly Ala Gly Tyr Gly Val Gly Arg Thr Pro Lys Gln Gly Ala Cys 
    210                 215                 220                 


Val Ile Trp Gln Arg Gly Val Gln Gly Gly Ser Pro Gln Tyr Gly His 
225                 230                 235                 240 


Val Ala Phe Val Glu Lys Val Leu Asp Gly Gly Lys Lys Ile Phe Ile 
                245                 250                 255     


Ser Glu His Asn Tyr Ala Thr Pro Asn Gly Tyr Gly Thr Arg Thr Ile 
            260                 265                 270         


Asp Met Ser Ser Ala Ile Gly Lys Asn Ala Gln Phe Ile Tyr Asp Lys 
        275                 280                 285             


Lys Ser Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn 
    290                 295                 300                 


Lys Tyr Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn 
305                 310                 315                 320 


Thr Asp Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln 
                325                 330                 335     


Ser Gly Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met 
            340                 345                 350         


Lys Gln Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln 
        355                 360                 365             


Arg Ile Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu 
    370                 375                 380                 


Gly Val Leu Trp Gly Thr Ile Lys 
385                 390         


<210>  81
<211>  392
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPTw_SH3b2638

<400>  81

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Gln Asn Lys Asp 
    290                 295                 300                 


Gly Ile Trp Tyr Lys Ala Glu His Ala Ser Phe Thr Val Thr Ala Pro 
305                 310                 315                 320 


Glu Gly Ile Ile Thr Arg Tyr Lys Gly Pro Trp Thr Gly His Pro Gln 
                325                 330                 335     


Ala Gly Val Leu Gln Lys Gly Gln Thr Ile Lys Tyr Asp Glu Val Gln 
            340                 345                 350         


Lys Phe Asp Gly His Val Trp Val Ser Trp Glu Thr Phe Glu Gly Glu 
        355                 360                 365             


Thr Val Tyr Met Pro Val Arg Thr Trp Asp Ala Lys Thr Gly Lys Val 
    370                 375                 380                 


Gly Lys Leu Trp Gly Glu Ile Lys 
385                 390         


<210>  82
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPTw_SH3bAle1

<400>  82

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Tyr Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Ala Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Leu Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Arg Lys Gly Leu Thr Ile Lys Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Asn Thr Asn Ser Gly Lys Arg Val 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Glu Ser Thr Gly Glu Leu Gly Pro 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


<210>  83
<211>  390
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  M23LST_TCHAPTw_SH3bLST

<400>  83

Ala Ala Thr His Glu His Ser Ala Gln Trp Leu Asn Asn Tyr Lys Lys 
1               5                   10                  15      


Gly Tyr Gly Tyr Gly Pro Tyr Pro Leu Gly Ile Asn Gly Gly Met His 
            20                  25                  30          


Tyr Gly Val Asp Phe Phe Met Asn Ile Gly Thr Pro Val Lys Ala Ile 
        35                  40                  45              


Ser Ser Gly Lys Ile Val Glu Ala Gly Trp Ser Asn Tyr Gly Gly Gly 
    50                  55                  60                  


Asn Gln Ile Gly Leu Ile Glu Asn Asp Gly Val His Arg Gln Trp Tyr 
65                  70                  75                  80  


Met His Leu Ser Lys Tyr Asn Val Lys Val Gly Asp Tyr Val Lys Ala 
                85                  90                  95      


Gly Gln Ile Ile Gly Trp Ser Gly Ser Thr Gly Tyr Ser Thr Ala Pro 
            100                 105                 110         


His Leu His Phe Gln Arg Met Val Asn Ser Phe Ser Asn Ser Thr Ala 
        115                 120                 125             


Gln Asp Pro Met Pro Phe Leu Lys Ser Ala Gly Tyr Gly Ser Asn Ser 
    130                 135                 140                 


Thr Ser Ser Ser Asn Asn Asn Gly Gly Lys Glu Leu Pro Thr Pro Arg 
145                 150                 155                 160 


Asn Lys Thr Asp Thr Ser Trp Thr Ala Pro Gly Asn Pro Asn Thr Gly 
                165                 170                 175     


Gln Trp Ala Arg Glu Cys Thr Trp Tyr Cys Tyr Asn Arg Arg Tyr Glu 
            180                 185                 190         


Leu Gly Leu Lys Ala Val Ala Tyr Gly Asp Ala Ala Asp Trp Ile Ala 
        195                 200                 205             


Gly Ala Arg Gly Ala Gly Ile Ser Thr Gly Lys Glu Pro Lys Arg Gly 
    210                 215                 220                 


Ala Val Ala Val Trp Ala Arg Gly Val Pro Gly Gly Ser Ala Gln Tyr 
225                 230                 235                 240 


Gly His Val Ala Phe Val Glu Lys Val Thr Asp Asp Gly Ile Tyr Val 
                245                 250                 255     


Ser Asp Tyr Asn Tyr Ala Ser Pro Lys Thr Tyr Gly Glu Arg Leu Tyr 
            260                 265                 270         


Lys Lys Gly Ser Pro Glu Tyr Arg Asn Ala Gln Tyr Ile Tyr Asp Ser 
        275                 280                 285             


Asn Ser Thr Ser Ser Ser Asn Asn Asn Gly Trp Lys Thr Asn Lys Tyr 
    290                 295                 300                 


Gly Thr Leu Tyr Lys Ser Glu Ser Ala Ser Phe Thr Pro Asn Thr Asp 
305                 310                 315                 320 


Ile Ile Thr Arg Thr Thr Gly Pro Phe Arg Ser Met Pro Gln Ser Gly 
                325                 330                 335     


Val Leu Lys Ala Gly Gln Thr Ile His Tyr Asp Glu Val Met Lys Gln 
            340                 345                 350         


Asp Gly His Val Trp Val Gly Tyr Thr Gly Asn Ser Gly Gln Arg Ile 
        355                 360                 365             


Tyr Leu Pro Val Arg Thr Trp Asn Lys Ser Thr Asn Thr Leu Gly Val 
    370                 375                 380                 


Leu Trp Gly Thr Ile Lys 
385                 390 


