                         б

<110>  ϺƼɷ޹˾
 
<120>  һֿNectin-4Ŀ弰Ӧ

<130>  LC21210004P

<150>  CN202010320420.3
<151>  2020-04-21

<160>  97    

<170>  PatentIn version 3.3

<210>  1
<211>  447
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  Enfortumab, HC

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  2
<211>  214
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  Enfortumab, LC

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Gly Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Phe Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  318
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp 
1               5                   10                  15      


Ala Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly 
            20                  25                  30          


Gln Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu 
        35                  40                  45              


Ala Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu 
    50                  55                  60                  


Gly Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser 
65                  70                  75                  80  


Val Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys 
                85                  90                  95      


Arg Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu 
            100                 105                 110         


Arg Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu 
        115                 120                 125             


Glu Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly 
    130                 135                 140                 


Ser Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr 
145                 150                 155                 160 


Ser Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu 
                165                 170                 175     


Phe His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys 
            180                 185                 190         


Val Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile 
        195                 200                 205             


Leu His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp 
    210                 215                 220                 


Gln Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu 
225                 230                 235                 240 


Ser Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly 
                245                 250                 255     


Pro Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro 
            260                 265                 270         


Pro Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn 
        275                 280                 285             


Glu Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro 
    290                 295                 300                 


Gln Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser 
305                 310                 315             


<210>  4
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Leu Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Leu Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Leu Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  5
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  5

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  6
<211>  510
<212>  PRT
<213>  Cyno

<400>  6

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Ala Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Val Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Thr Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  7
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  7

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Thr Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  8
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  8

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Leu Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  10
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Leu Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  11
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  11

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  12
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  12

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Leu Ala Thr Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  13
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  13

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Ser Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  14
<211>  113
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  14

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ala Met Ser Val Gly 
1               5                   10                  15      


Gln Arg Val Thr Met Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ile Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile 
            100                 105                 110         


Lys 
    


<210>  15
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  15

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  16
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  16

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  17
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  17

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Glu Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  18
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  18

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  19
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  19

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Asp Ala Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  20
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  20

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Asp Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  119
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  21

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ile Asp Tyr 
            20                  25                  30          


Gly Val Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Gly Gly Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  22
<211>  114
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  22

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  23
<211>  114
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  23

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Ser 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  24
<211>  114
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  24

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  25
<211>  114
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Thr 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  26
<211>  114
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Asn Lys 
            20                  25                  30          


Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


His Tyr Asn Thr Pro Phe Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu 
            100                 105                 110         


Lys Arg 
        


<210>  27
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Ser Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  28
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  28

Ser Val Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Asn Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Asn Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  29
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  29

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  30
<211>  116
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Arg Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Val Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  31
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  31

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Asn Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  32
<211>  107
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  32

Glu Val Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Asn Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  33
<211>  117
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VH

<400>  33

Glu Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Asp Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Arg Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Val Asn Pro Asn Asn Gly Asn Thr Leu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Arg Gly Lys Ala Ile Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Arg Tyr Ala Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  34
<211>  111
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  VL

<400>  34

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Ser Thr Ser 
            20                  25                  30          


Ser Tyr Thr Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ile Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Thr Ala Thr Tyr Tyr Cys Gln His Thr Trp 
                85                  90                  95      


Glu Ile Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  35
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  35

Gly Tyr Thr Phe Thr Thr Tyr 
1               5           


<210>  36
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  36

Gly Tyr Thr Phe Thr Thr Tyr Tyr Ile His 
1               5                   10  


<210>  37
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  37

Thr Tyr Tyr Ile His 
1               5   


<210>  38
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  38

Thr Thr Tyr Tyr Ile His 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  39

Tyr Pro Gly Asn Val Asn 
1               5       


<210>  40
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  40

Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys 
1               5                   10  


<210>  41
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  41

Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  42
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  42

Trp Ile Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys 
1               5                   10              


<210>  43
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  43

Gly Leu Tyr Tyr Phe Asp Tyr 
1               5           


<210>  44
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  44

Ala Arg Gly Leu Tyr Tyr Phe Asp 
1               5               


<210>  45
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  45

Lys Ala Ser Gln Ser Val Ser Asn Asp Val Ala 
1               5                   10      


<210>  46
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  46

Ser Asn Asp Val Ala Trp Tyr 
1               5           


<210>  47
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  47

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  48
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  48

Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr 
1               5                   10  


<210>  49
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  49

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  50
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  50

Gln Gln Asp Tyr Ser Ser Pro Tyr 
1               5               


<210>  51
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  51

Gly Phe Ser Leu Ile Asp Tyr 
1               5           


<210>  52
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  52

Gly Phe Ser Leu Ile Asp Tyr Gly Val Ser 
1               5                   10  


<210>  53
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  53

Asp Tyr Gly Val Ser 
1               5   


<210>  54
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  54

Ile Asp Tyr Gly Val Ser 
1               5       


<210>  55
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  55

Trp Gly Asp Gly Lys 
1               5   


<210>  56
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  56

Val Ile Trp Gly Asp Gly Lys Ile Tyr 
1               5                   


<210>  57
<211>  16
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  57

Val Ile Trp Gly Asp Gly Lys Ile Tyr Tyr Asn Ser Val Leu Lys Ser 
1               5                   10                  15      


<210>  58
<211>  12
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  58

Trp Leu Gly Val Ile Trp Gly Asp Gly Lys Ile Tyr 
1               5                   10          


<210>  59
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  59

Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  60
<211>  12
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  60

Ala Lys Gln Gly Gly Leu Leu Phe Tyr Ala Met Asp 
1               5                   10          


<210>  61
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  61

Lys Ser Ser Gln Ser Leu Leu Asn Ser Tyr Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  62
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  62

Leu Asn Ser Tyr Ser Gln Lys Asn Tyr Leu Ala Trp Tyr 
1               5                   10              


<210>  63
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  63

Phe Ala Ser Thr Arg Glu Ser 
1               5           


<210>  64
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  64

Leu Leu Ile Tyr Phe Ala Ser Thr Arg Glu 
1               5                   10  


<210>  65
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  65

Gln Gln His Tyr Asn Thr Pro Phe Thr 
1               5                   


<210>  66
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  66

Gln Gln His Tyr Asn Thr Pro Phe 
1               5               


<210>  67
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  67

Lys Ser Ser Gln Ser Leu Leu Asn Thr Tyr Ser Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  68
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  68

Trp Gly Asp Ala Lys 
1               5   


<210>  69
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  69

Trp Gly Gly Gly Lys 
1               5   


<210>  70
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  70

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  71
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  71

Gly Tyr Thr Phe Thr Ser Tyr Tyr Ile His 
1               5                   10  


<210>  72
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  72

Ser Tyr Tyr Ile His 
1               5   


<210>  73
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  73

Thr Ser Tyr Tyr Ile His 
1               5       


<210>  74
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  74

Tyr Pro Gly Asn Ala Asn 
1               5       


<210>  75
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  75

Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys 
1               5                   10  


<210>  76
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  76

Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys Tyr Asn Glu Asn Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  77
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  77

Trp Ile Gly Trp Ile Tyr Pro Gly Asn Ala Asn Asn Lys 
1               5                   10              


<210>  78
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  78

Ser Val Tyr Tyr Phe Asp Tyr 
1               5           


<210>  79
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  79

Ala Arg Ser Val Tyr Tyr Phe Asp 
1               5               


<210>  80
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  80

Tyr Ala Ser Asn Arg Asn Thr 
1               5           


<210>  81
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  81

Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Asn 
1               5                   10  


<210>  82
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  82

Gly Tyr Ser Phe Thr Asp Tyr 
1               5           


<210>  83
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  83

Gly Tyr Ser Phe Thr Asp Tyr Tyr Met His 
1               5                   10  


<210>  84
<211>  5
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  84

Asp Tyr Tyr Met His 
1               5   


<210>  85
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H1

<400>  85

Thr Asp Tyr Tyr Met His 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  86

Asn Pro Asn Asn Gly Asn 
1               5       


<210>  87
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  87

Arg Val Asn Pro Asn Asn Gly Asn Thr Leu 
1               5                   10  


<210>  88
<211>  17
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  88

Arg Val Asn Pro Asn Asn Gly Asn Thr Leu Tyr Asn Gln Lys Phe Arg 
1               5                   10                  15      


Gly 
    


<210>  89
<211>  13
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H2

<400>  89

Trp Ile Gly Arg Val Asn Pro Asn Asn Gly Asn Thr Leu 
1               5                   10              


<210>  90
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  90

Glu Asp Arg Tyr Ala Phe Ala Tyr 
1               5               


<210>  91
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-H3

<400>  91

Ala Arg Glu Asp Arg Tyr Ala Phe Ala 
1               5                   


<210>  92
<211>  15
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  92

Arg Ala Ser Gln Ser Val Ser Thr Ser Ser Tyr Thr Tyr Met His 
1               5                   10                  15  


<210>  93
<211>  11
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L1

<400>  93

Ser Thr Ser Ser Tyr Thr Tyr Met His Trp Tyr 
1               5                   10      


<210>  94
<211>  7
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  94

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  95
<211>  10
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L2

<400>  95

Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu 
1               5                   10  


<210>  96
<211>  9
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  96

Gln His Thr Trp Glu Ile Pro Tyr Thr 
1               5                   


<210>  97
<211>  8
<212>  PRT
<213>  ˹(artificial sequence)

<220>
<223>  CDR-L3

<400>  97

Gln His Thr Trp Glu Ile Pro Tyr 
1               5               


