                               SEQUENCE LISTING

<110> SHAPE THERAPEUTICS INC.
 
<120> TARGETED RNA EDITING USING ENGINEERED ADENOSINE DEAMINASE ACTING 
      ON TRNA (ADAT) SYSTEMS

<130> 36856-45740/WO (101WO)

<140> PCT/US2021/027552
<141> 2021-04-15

<150> 63/010,629
<151> 2020-04-15

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 73
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Arginine tRNA sequence

<400> 1
gggccagugg cgcaauggau aacgcgucug acuucagauc agaagauucc agguucgacu       60

ccuggcuggc ucg                                                          73


<210> 2
<211> 97
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(16)
<223> a, c, u, g, unknown or other

<220>
<221> modified_base
<222> (81)..(97)
<223> a, c, u, g, unknown or other

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 2
nnnnnnnnnn nnnnnncagu ggcgcaaugg auaacgcguc ugacuucaga ucagaagauu       60

ccagguucga cuccuggcug nnnnnnnnnn nnnnnnn                                97


<210> 3
<211> 502
<212> PRT
<213> Homo sapiens

<400> 3
Met Trp Thr Ala Asp Glu Ile Ala Gln Leu Cys Tyr Glu His Tyr Gly 
1               5                   10                  15      


Ile Arg Leu Pro Lys Lys Gly Lys Pro Glu Pro Asn His Glu Trp Thr 
            20                  25                  30          


Leu Leu Ala Ala Val Val Lys Ile Gln Ser Pro Ala Asp Lys Ala Cys 
        35                  40                  45              


Asp Thr Pro Asp Lys Pro Val Gln Val Thr Lys Glu Val Val Ser Met 
    50                  55                  60                  


Gly Thr Gly Thr Lys Cys Ile Gly Gln Ser Lys Met Arg Lys Asn Gly 
65                  70                  75                  80  


Asp Ile Leu Asn Asp Ser His Ala Glu Val Ile Ala Arg Arg Ser Phe 
                85                  90                  95      


Gln Arg Tyr Leu Leu His Gln Leu Gln Leu Ala Ala Thr Leu Lys Glu 
            100                 105                 110         


Asp Ser Ile Phe Val Pro Gly Thr Gln Lys Gly Val Trp Lys Leu Arg 
        115                 120                 125             


Arg Asp Leu Ile Phe Val Phe Phe Ser Ser His Thr Pro Cys Gly Asp 
    130                 135                 140                 


Ala Ser Ile Ile Pro Met Leu Glu Phe Glu Asp Gln Pro Cys Cys Pro 
145                 150                 155                 160 


Val Phe Arg Asn Trp Ala His Asn Ser Ser Val Glu Ala Ser Ser Asn 
                165                 170                 175     


Leu Glu Ala Pro Gly Asn Glu Arg Lys Cys Glu Asp Pro Asp Ser Pro 
            180                 185                 190         


Val Thr Lys Lys Met Arg Leu Glu Pro Gly Thr Ala Ala Arg Glu Val 
        195                 200                 205             


Thr Asn Gly Ala Ala His His Gln Ser Phe Gly Lys Gln Lys Ser Gly 
    210                 215                 220                 


Pro Ile Ser Pro Gly Ile His Ser Cys Asp Leu Thr Val Glu Gly Leu 
225                 230                 235                 240 


Ala Thr Val Thr Arg Ile Ala Pro Gly Ser Ala Lys Val Ile Asp Val 
                245                 250                 255     


Tyr Arg Thr Gly Ala Lys Cys Val Pro Gly Glu Ala Gly Asp Ser Gly 
            260                 265                 270         


Lys Pro Gly Ala Ala Phe His Gln Val Gly Leu Leu Arg Val Lys Pro 
        275                 280                 285             


Gly Arg Gly Asp Arg Thr Arg Ser Met Ser Cys Ser Asp Lys Met Ala 
    290                 295                 300                 


Arg Trp Asn Val Leu Gly Cys Gln Gly Ala Leu Leu Met His Leu Leu 
305                 310                 315                 320 


Glu Glu Pro Ile Tyr Leu Ser Ala Val Val Ile Gly Lys Cys Pro Tyr 
                325                 330                 335     


Ser Gln Glu Ala Met Gln Arg Ala Leu Ile Gly Arg Cys Gln Asn Val 
            340                 345                 350         


Ser Ala Leu Pro Lys Gly Phe Gly Val Gln Glu Leu Lys Ile Leu Gln 
        355                 360                 365             


Ser Asp Leu Leu Phe Glu Gln Ser Arg Ser Ala Val Gln Ala Lys Arg 
    370                 375                 380                 


Ala Asp Ser Pro Gly Arg Leu Val Pro Cys Gly Ala Ala Ile Ser Trp 
385                 390                 395                 400 


Ser Ala Val Pro Glu Gln Pro Leu Asp Val Thr Ala Asn Gly Phe Pro 
                405                 410                 415     


Gln Gly Thr Thr Lys Lys Thr Ile Gly Ser Leu Gln Ala Arg Ser Gln 
            420                 425                 430         


Ile Ser Lys Val Glu Leu Phe Arg Ser Phe Gln Lys Leu Leu Ser Arg 
        435                 440                 445             


Ile Ala Arg Asp Lys Trp Pro His Ser Leu Arg Val Gln Lys Leu Asp 
    450                 455                 460                 


Thr Tyr Gln Glu Tyr Lys Glu Ala Ala Ser Ser Tyr Gln Glu Ala Trp 
465                 470                 475                 480 


Ser Thr Leu Arg Lys Gln Val Phe Gly Ser Trp Ile Arg Asn Pro Pro 
                485                 490                 495     


Asp Tyr His Gln Phe Lys 
            500         


<210> 4
<211> 191
<212> PRT
<213> Homo sapiens

<400> 4
Met Glu Ala Lys Ala Ala Pro Lys Pro Ala Ala Ser Gly Ala Cys Ser 
1               5                   10                  15      


Val Ser Ala Glu Glu Thr Glu Lys Trp Met Glu Glu Ala Met His Met 
            20                  25                  30          


Ala Lys Glu Ala Leu Glu Asn Thr Glu Val Pro Val Gly Cys Leu Met 
        35                  40                  45              


Val Tyr Asn Asn Glu Val Val Gly Lys Gly Arg Asn Glu Val Asn Gln 
    50                  55                  60                  


Thr Lys Asn Ala Thr Arg His Ala Glu Met Val Ala Ile Asp Gln Val 
65                  70                  75                  80  


Leu Asp Trp Cys Arg Gln Ser Gly Lys Ser Pro Ser Glu Val Phe Glu 
                85                  90                  95      


His Thr Val Leu Tyr Val Thr Val Glu Pro Cys Ile Met Cys Ala Ala 
            100                 105                 110         


Ala Leu Arg Leu Met Lys Ile Pro Leu Val Val Tyr Gly Cys Gln Asn 
        115                 120                 125             


Glu Arg Phe Gly Gly Cys Gly Ser Val Leu Asn Ile Ala Ser Ala Asp 
    130                 135                 140                 


Leu Pro Asn Thr Gly Arg Pro Phe Gln Cys Ile Pro Gly Tyr Arg Ala 
145                 150                 155                 160 


Glu Glu Ala Val Glu Met Leu Lys Thr Phe Tyr Lys Gln Glu Asn Pro 
                165                 170                 175     


Asn Ala Pro Lys Ser Lys Val Arg Lys Lys Glu Cys Gln Lys Ser 
            180                 185                 190     


<210> 5
<211> 351
<212> PRT
<213> Homo sapiens

<400> 5
Met Glu Pro Ala Pro Gly Leu Val Glu Gln Pro Lys Cys Leu Glu Ala 
1               5                   10                  15      


Gly Ser Pro Glu Pro Glu Pro Ala Pro Trp Gln Ala Leu Pro Val Leu 
            20                  25                  30          


Ser Glu Lys Gln Ser Gly Asp Val Glu Leu Val Leu Ala Tyr Ala Ala 
        35                  40                  45              


Pro Val Leu Asp Lys Arg Gln Thr Ser Arg Leu Leu Lys Glu Val Ser 
    50                  55                  60                  


Ala Leu His Pro Leu Pro Ala Gln Pro His Leu Lys Arg Val Arg Pro 
65                  70                  75                  80  


Ser Arg Asp Ala Gly Ser Pro His Ala Leu Glu Met Leu Leu Cys Leu 
                85                  90                  95      


Ala Gly Pro Ala Ser Gly Pro Arg Ser Leu Ala Glu Leu Leu Pro Arg 
            100                 105                 110         


Pro Ala Val Asp Pro Arg Gly Leu Gly Gln Pro Phe Leu Val Pro Val 
        115                 120                 125             


Pro Ala Arg Pro Pro Leu Thr Arg Gly Gln Phe Glu Glu Ala Arg Ala 
    130                 135                 140                 


His Trp Pro Thr Ser Phe His Glu Asp Lys Gln Val Thr Ser Ala Leu 
145                 150                 155                 160 


Ala Gly Arg Leu Phe Ser Thr Gln Glu Arg Ala Ala Met Gln Ser His 
                165                 170                 175     


Met Glu Arg Ala Val Trp Ala Ala Arg Arg Ala Ala Ala Arg Gly Leu 
            180                 185                 190         


Arg Ala Val Gly Ala Val Val Val Asp Pro Ala Ser Asp Arg Val Leu 
        195                 200                 205             


Ala Thr Gly His Asp Cys Ser Cys Ala Asp Asn Pro Leu Leu His Ala 
    210                 215                 220                 


Val Met Val Cys Val Asp Leu Val Ala Arg Gly Gln Gly Arg Gly Thr 
225                 230                 235                 240 


Tyr Asp Phe Arg Pro Phe Pro Ala Cys Ser Phe Ala Pro Ala Ala Ala 
                245                 250                 255     


Pro Gln Ala Val Arg Ala Gly Ala Val Arg Lys Leu Asp Ala Asp Glu 
            260                 265                 270         


Asp Gly Leu Pro Tyr Leu Cys Thr Gly Tyr Asp Leu Tyr Val Thr Arg 
        275                 280                 285             


Glu Pro Cys Ala Met Cys Ala Met Ala Leu Val His Ala Arg Ile Leu 
    290                 295                 300                 


Arg Val Phe Tyr Gly Ala Pro Ser Pro Asp Gly Ala Leu Gly Thr Arg 
305                 310                 315                 320 


Phe Arg Ile His Ala Arg Pro Asp Leu Asn His Arg Phe Gln Val Phe 
                325                 330                 335     


Arg Gly Val Leu Glu Glu Gln Cys Arg Trp Leu Asp Pro Asp Thr 
            340                 345                 350     


<210> 6
<211> 72
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Proline tRNA sequence

<400> 6
ggctcgttgg tctaggggta tgattctcgc ttaggatgcg agaggtcccg ggttcaaatc       60

ccggacgagc cc                                                           72


<210> 7
<211> 82
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Leucine tRNA sequence

<400> 7
ggtagcgtgg ccgagcggtc taaggcgctg gattaaggct ccagtctctt cggaggcgtg       60

ggttcgaatc ccaccgctgc ca                                                82


<210> 8
<211> 73
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Valine tRNA sequence

<400> 8
gtttccgtag tgtagtggtt atcacgttcg cctaacacgc gaaaggtccc cggttcgaaa       60

ccgggcggaa aca                                                          73


<210> 9
<211> 82
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Serine tRNA sequence

<400> 9
gtagtcgtgg ccgagtggtt aaggcgatgg actagaaatc cattggggtt tccccgcgca       60

ggttcgaatc ctgccgacta cg                                                82


<210> 10
<211> 72
<212> RNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Alanine tRNA (yeast) sequence

<400> 10
gggcguuggc guaguaagua gcgcgcuccc uuagcauggg agaggucucc guucgauucg       60

gaucguccac ca                                                           72


<210> 11
<211> 73
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Alanine tRNA sequence

<400> 11
gggggattag ctcaaatggt agagcgctcg cttagcatgc gagaggtagc gggatcgatg       60

cccgcatcct cca                                                          73


<210> 12
<211> 74
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Threonine tRNA sequence

<400> 12
ggcgccgtgg cttagttggt taaagcgcct gtctagtaaa caggagatcc tgggttcgaa       60

tcccagcggt gcct                                                         74


<210> 13
<211> 74
<212> DNA
<213> Unknown

<220>
<223> Description of Unknown: 
      Isoleucine tRNA sequence

<400> 13
ggctggttag ttcagttggt tagagcgtgg tgctaataac gccaaggtcg tgggttcgat       60

ccccatatcg gcca                                                         74


