                         SEQUENCE LISTING

<110>  Cartesian Therapeutics, Inc.
 
<120>  ENGINEERED CELLS SECRETING THERAPEUTIC ENZYMES

<130>  C1540.70002WO00

<140>  Not Yet Assigned
<141>  Concurrently Herewith

<150>  US 63/047,516
<151>  2020-07-02

<150>  US 63/010,489
<151>  2020-04-15

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  282
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys 
        275                 280         


<210>  2
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Met Ser Arg Glu Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His 
1               5                   10                  15      


Ser Ala Leu Ala Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly 
            20                  25                  30          


Glu Ser Lys Gln Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val 
        35                  40                  45              


Ile Lys Arg Cys Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn 
    50                  55                  60                  


Asn Arg Ile Cys Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg 
65                  70                  75                  80  


Arg Gly Ile Thr Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn 
                85                  90                  95      


Thr Tyr Lys Glu Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser 
            100                 105                 110         


Val Lys Arg Ser Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp 
        115                 120                 125             


Val Phe Ser Arg Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr 
    130                 135                 140                 


Ala Val Lys Asp Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr 
145                 150                 155                 160 


Ser Val Lys Glu Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys 
                165                 170                 175     


His Arg Trp Lys Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala 
            180                 185                 190         


Gly Cys Ser Tyr Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg 
        195                 200                 205             


Thr Asp Pro Arg Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr 
    210                 215                 220                 


Val Lys Lys Ser Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly 
225                 230                 235                 240 


Gln Glu Ile Val Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp 
                245                 250                 255     


Phe Gln Lys Ala Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser 
            260                 265                 270         


Asp His Phe Pro Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr 
        275                 280                 285             


Asn Ser Lys Lys Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg 
    290                 295                 300                 


Ser 
305 


<210>  3
<211>  605
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Met Arg Gly Met Lys Leu Leu Gly Ala Leu Leu Ala Leu Ala Ala Leu 
1               5                   10                  15      


Leu Gln Gly Ala Val Ser Leu Lys Ile Ala Ala Phe Asn Ile Gln Thr 
            20                  25                  30          


Phe Gly Glu Thr Lys Met Ser Asn Ala Thr Leu Val Ser Tyr Ile Val 
        35                  40                  45              


Gln Ile Leu Ser Arg Tyr Asp Ile Ala Leu Val Gln Glu Val Arg Asp 
    50                  55                  60                  


Ser His Leu Thr Ala Val Gly Lys Leu Leu Asp Asn Leu Asn Gln Asp 
65                  70                  75                  80  


Ala Pro Asp Thr Tyr His Tyr Val Val Ser Glu Pro Leu Gly Arg Asn 
                85                  90                  95      


Ser Tyr Lys Glu Arg Tyr Leu Phe Val Tyr Arg Pro Asp Gln Val Ser 
            100                 105                 110         


Ala Val Asp Ser Tyr Tyr Tyr Asp Asp Gly Cys Glu Pro Cys Gly Asn 
        115                 120                 125             


Asp Thr Phe Asn Arg Glu Pro Ala Ile Val Arg Phe Phe Ser Arg Phe 
    130                 135                 140                 


Thr Glu Val Arg Glu Phe Ala Ile Val Pro Leu His Ala Ala Pro Gly 
145                 150                 155                 160 


Asp Ala Val Ala Glu Ile Asp Ala Leu Tyr Asp Val Tyr Leu Asp Val 
                165                 170                 175     


Gln Glu Lys Trp Gly Leu Glu Asp Val Met Leu Met Gly Asp Phe Asn 
            180                 185                 190         


Ala Gly Cys Ser Tyr Val Arg Pro Ser Gln Trp Ser Ser Ile Arg Leu 
        195                 200                 205             


Trp Thr Ser Pro Thr Phe Gln Trp Leu Ile Pro Asp Ser Ala Asp Thr 
    210                 215                 220                 


Thr Ala Thr Pro Thr His Cys Ala Tyr Asp Arg Ile Val Val Ala Gly 
225                 230                 235                 240 


Met Leu Leu Arg Gly Ala Val Val Pro Asp Ser Ala Leu Pro Phe Asn 
                245                 250                 255     


Phe Gln Ala Ala Tyr Gly Leu Ser Asp Gln Leu Ala Gln Ala Ile Ser 
            260                 265                 270         


Asp His Tyr Pro Val Glu Val Met Leu Lys Glu Gly Arg Gly Ser Leu 
        275                 280                 285             


Leu Thr Cys Gly Asp Val Glu Glu Asn Pro Gly Pro Met Ser Arg Glu 
    290                 295                 300                 


Leu Ala Pro Leu Leu Leu Leu Leu Leu Ser Ile His Ser Ala Leu Ala 
305                 310                 315                 320 


Met Arg Ile Cys Ser Phe Asn Val Arg Ser Phe Gly Glu Ser Lys Gln 
                325                 330                 335     


Glu Asp Lys Asn Ala Met Asp Val Ile Val Lys Val Ile Lys Arg Cys 
            340                 345                 350         


Asp Ile Ile Leu Val Met Glu Ile Lys Asp Ser Asn Asn Arg Ile Cys 
        355                 360                 365             


Pro Ile Leu Met Glu Lys Leu Asn Arg Asn Ser Arg Arg Gly Ile Thr 
    370                 375                 380                 


Tyr Asn Tyr Val Ile Ser Ser Arg Leu Gly Arg Asn Thr Tyr Lys Glu 
385                 390                 395                 400 


Gln Tyr Ala Phe Leu Tyr Lys Glu Lys Leu Val Ser Val Lys Arg Ser 
                405                 410                 415     


Tyr His Tyr His Asp Tyr Gln Asp Gly Asp Ala Asp Val Phe Ser Arg 
            420                 425                 430         


Glu Pro Phe Val Val Trp Phe Gln Ser Pro His Thr Ala Val Lys Asp 
        435                 440                 445             


Phe Val Ile Ile Pro Leu His Thr Thr Pro Glu Thr Ser Val Lys Glu 
    450                 455                 460                 


Ile Asp Glu Leu Val Glu Val Tyr Thr Asp Val Lys His Arg Trp Lys 
465                 470                 475                 480 


Ala Glu Asn Phe Ile Phe Met Gly Asp Phe Asn Ala Gly Cys Ser Tyr 
                485                 490                 495     


Val Pro Lys Lys Ala Trp Lys Asn Ile Arg Leu Arg Thr Asp Pro Arg 
            500                 505                 510         


Phe Val Trp Leu Ile Gly Asp Gln Glu Asp Thr Thr Val Lys Lys Ser 
        515                 520                 525             


Thr Asn Cys Ala Tyr Asp Arg Ile Val Leu Arg Gly Gln Glu Ile Val 
    530                 535                 540                 


Ser Ser Val Val Pro Lys Ser Asn Ser Val Phe Asp Phe Gln Lys Ala 
545                 550                 555                 560 


Tyr Lys Leu Thr Glu Glu Glu Ala Leu Asp Val Ser Asp His Phe Pro 
                565                 570                 575     


Val Glu Phe Lys Leu Gln Ser Ser Arg Ala Phe Thr Asn Ser Lys Lys 
            580                 585                 590         


Ser Val Thr Leu Arg Lys Lys Thr Lys Ser Lys Arg Ser 
        595                 600                 605 


<210>  4
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
            20                  25                  30          


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
        35                  40                  45              


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
    50                  55                  60                  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
65                  70                  75                  80  


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
                85                  90                  95      


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
            100                 105                 110         


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
        115                 120                 125             


Gln Met Phe Ile Asn Thr Ser Phe Val Pro Val Phe Leu Pro Ala Lys 
    130                 135                 140                 


Pro Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile 
145                 150                 155                 160 


Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala 
                165                 170                 175     


Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr 
            180                 185                 190         


Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu 
        195                 200                 205             


Val Ile Thr Leu Tyr Cys Asn His Arg Asn Gly Gly Ser Asp Tyr Lys 
    210                 215                 220                 


Asp Asp Asp Asp Lys 
225                 


<210>  5
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Thr Ile Pro Pro His 
            20                  25                  30          


Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp Asn Asn Gly 
        35                  40                  45              


Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val Arg Phe Ser 
    50                  55                  60                  


Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser Ile Thr Ser 
65                  70                  75                  80  


Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp Arg Lys Asn 
                85                  90                  95      


Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro Lys Leu Pro 
            100                 105                 110         


Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys Cys Ile Met 
        115                 120                 125             


Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys Ser Cys Ser 
    130                 135                 140                 


Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr 
145                 150                 155                 160 


Ser Asn Pro Asp Thr Ile Pro Pro His Val Gln Lys Ser Val Asn Asn 
                165                 170                 175     


Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln Leu 
            180                 185                 190         


Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser 
        195                 200                 205             


Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu 
    210                 215                 220                 


Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu 
225                 230                 235                 240 


Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu Glu 
                245                 250                 255     


Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro Gly 
            260                 265                 270         


Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn 
        275                 280                 285             


Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Gly Thr Gly 
    290                 295                 300                 


Gly Ser Ser Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
305                 310                 315                 320 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                325                 330                 335     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            340                 345                 350         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        355                 360                 365             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    370                 375                 380                 


Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Gly Ser Leu Gln Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
                405                 410                 415     


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
            420                 425                 430         


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
        435                 440                 445             


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
    450                 455                 460                 


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
465                 470                 475                 480 


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
                485                 490                 495     


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
            500                 505                 510         


Gln Met Phe Ile Asn Thr Ser 
        515                 


<210>  6
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Tyr Lys Asp Asp Asp Asp Lys Asn Trp Val Asn Val 
            20                  25                  30          


Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile Gln Ser Met His Ile 
        35                  40                  45              


Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His Pro Ser Cys Lys Val 
    50                  55                  60                  


Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln Val Ile Ser Leu Glu 
65                  70                  75                  80  


Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu Asn Leu Ile Ile Leu 
                85                  90                  95      


Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val Thr Glu Ser Gly Cys 
            100                 105                 110         


Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln 
        115                 120                 125             


Ser Phe Val His Ile Val Gln Met Phe Ile Asn Thr Ser Gly Thr Gly 
    130                 135                 140                 


Gly Ser Ser Gly Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala 
145                 150                 155                 160 


Asp Ile Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile 
                165                 170                 175     


Cys Asn Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu 
            180                 185                 190         


Cys Val Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser 
        195                 200                 205             


Leu Lys Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro 
    210                 215                 220                 


Pro Ser Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
225                 230                 235                 240 


Gly Gly Ser Leu Gln Thr Ile Pro Pro His Val Gln Lys Ser Val Asn 
                245                 250                 255     


Asn Asp Met Ile Val Thr Asp Asn Asn Gly Ala Val Lys Phe Pro Gln 
            260                 265                 270         


Leu Cys Lys Phe Cys Asp Val Arg Phe Ser Thr Cys Asp Asn Gln Lys 
        275                 280                 285             


Ser Cys Met Ser Asn Cys Ser Ile Thr Ser Ile Cys Glu Lys Pro Gln 
    290                 295                 300                 


Glu Val Cys Val Ala Val Trp Arg Lys Asn Asp Glu Asn Ile Thr Leu 
305                 310                 315                 320 


Glu Thr Val Cys His Asp Pro Lys Leu Pro Tyr His Asp Phe Ile Leu 
                325                 330                 335     


Glu Asp Ala Ala Ser Pro Lys Cys Ile Met Lys Glu Lys Lys Lys Pro 
            340                 345                 350         


Gly Glu Thr Phe Phe Met Cys Ser Cys Ser Ser Asp Glu Cys Asn Asp 
        355                 360                 365             


Asn Ile Ile Phe Ser Glu Glu Tyr Asn Thr Ser Asn Pro Asp Thr Ile 
    370                 375                 380                 


Pro Pro His Val Gln Lys Ser Val Asn Asn Asp Met Ile Val Thr Asp 
385                 390                 395                 400 


Asn Asn Gly Ala Val Lys Phe Pro Gln Leu Cys Lys Phe Cys Asp Val 
                405                 410                 415     


Arg Phe Ser Thr Cys Asp Asn Gln Lys Ser Cys Met Ser Asn Cys Ser 
            420                 425                 430         


Ile Thr Ser Ile Cys Glu Lys Pro Gln Glu Val Cys Val Ala Val Trp 
        435                 440                 445             


Arg Lys Asn Asp Glu Asn Ile Thr Leu Glu Thr Val Cys His Asp Pro 
    450                 455                 460                 


Lys Leu Pro Tyr His Asp Phe Ile Leu Glu Asp Ala Ala Ser Pro Lys 
465                 470                 475                 480 


Cys Ile Met Lys Glu Lys Lys Lys Pro Gly Glu Thr Phe Phe Met Cys 
                485                 490                 495     


Ser Cys Ser Ser Asp Glu Cys Asn Asp Asn Ile Ile Phe Ser Glu Glu 
            500                 505                 510         


Tyr Asn Thr Ser Asn Pro Asp 
        515                 


<210>  7
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Met Asp Ser Asn Thr Val Ser Ser Phe Gln Val Asp Cys Phe Leu Trp 
1               5                   10                  15      


His Val Arg Lys Gln Val Ala Asp Gln Glu Leu Gly Asp Ala Pro Phe 
            20                  25                  30          


Leu Asp Arg Leu Arg Arg Asp Gln Lys Ser Leu Lys Gly Arg Gly Ser 
        35                  40                  45              


Thr Leu Gly Leu Asn Ile Glu Thr Ala Thr Cys Val Gly Lys Gln Ile 
    50                  55                  60                  


Val Glu Arg Ile Leu Lys Glu Glu Ser Asp Glu Ala Phe Arg Met Thr 
65                  70                  75                  80  


Met Ala Ser Ala Leu Ala Ser Arg Tyr Leu Thr Asp Met Thr Ile Glu 
                85                  90                  95      


Glu Met Ser Arg Asp Trp Phe Met Leu Met Pro Lys Gln Lys Val Ala 
            100                 105                 110         


Gly Pro Leu Cys Val Arg Met Asp Gln Ala Ile Met Asp Lys Asn Ile 
        115                 120                 125             


Ile Leu Lys Ala Asn Phe Ser Val Ile Phe Asp Arg Leu Glu Thr Leu 
    130                 135                 140                 


Thr Leu Leu Arg Ala Phe Thr Glu Glu Gly Ala Ile Val Gly Glu Ile 
145                 150                 155                 160 


Ser Pro Leu Pro Ser Leu Pro Gly His Thr Asn Glu Asp Val Lys Asn 
                165                 170                 175     


Ala Ile Gly Val Leu Ile Gly Gly Leu Glu Trp Asn Asp Asn Thr Val 
            180                 185                 190         


Arg Val Ser Glu Thr Leu Gln Arg Phe Ala Trp Arg Ser Ser Asn Glu 
        195                 200                 205             


Asn Gly Gly Pro Pro Leu Thr Pro Thr Gln Lys Arg Lys Met Ala Gly 
    210                 215                 220                 


Lys Ile Arg Ser Glu Val 
225                 230 


<210>  8
<211>  190
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Met Ser Lys Ile Tyr Ile Asp Glu Arg Ser Asp Ala Glu Ile Val Cys 
1               5                   10                  15      


Ala Ala Ile Lys Asn Ile Gly Ile Glu Gly Ala Thr Ala Ala Gln Leu 
            20                  25                  30          


Thr Arg Gln Leu Asn Met Glu Lys Arg Glu Val Asn Lys Ala Leu Tyr 
        35                  40                  45              


Asp Leu Gln Arg Ser Ala Met Val Tyr Ser Ser Asp Asp Ile Pro Pro 
    50                  55                  60                  


Arg Trp Phe Met Thr Thr Glu Ala Asp Lys Pro Asp Ala Asp Ala Met 
65                  70                  75                  80  


Ala Asp Val Ile Ile Asp Asp Val Ser Arg Glu Lys Ser Met Arg Glu 
                85                  90                  95      


Asp His Lys Ser Phe Asp Asp Val Ile Pro Ala Lys Lys Ile Ile Asp 
            100                 105                 110         


Trp Lys Asp Ala Asn Pro Val Thr Ile Ile Asn Glu Tyr Cys Gln Ile 
        115                 120                 125             


Thr Lys Arg Asp Trp Ser Phe Arg Ile Glu Ser Val Gly Pro Ser Asn 
    130                 135                 140                 


Ser Pro Thr Phe Tyr Ala Cys Val Asp Ile Asp Gly Arg Val Phe Asp 
145                 150                 155                 160 


Lys Ala Asp Gly Lys Ser Lys Arg Asp Ala Lys Asn Asn Ala Ala Lys 
                165                 170                 175     


Leu Ala Val Asp Lys Leu Leu Gly Tyr Val Ile Ile Arg Phe 
            180                 185                 190 


<210>  9
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Met Val Val Val Ala Ala Ala Pro Asn Pro Ala Asp Gly Thr Pro Lys 
1               5                   10                  15      


Val Leu Leu Leu Ser Gly Gln Pro Ala Ser Ala Ala Gly Ala Pro Ala 
            20                  25                  30          


Gly Gln Ala Leu Pro Leu Met Val Pro Ala Gln Arg Gly Ala Ser Pro 
        35                  40                  45              


Glu Ala Ala Ser Gly Gly Leu Pro Gln Ala Arg Lys Arg Gln Arg Leu 
    50                  55                  60                  


Thr His Leu Ser Pro Glu Glu Lys Ala Leu Arg Arg Lys Leu Lys Asn 
65                  70                  75                  80  


Arg Val Ala Ala Gln Thr Ala Arg Asp Arg Lys Lys Ala Arg Met Ser 
                85                  90                  95      


Glu Leu Glu Gln Gln Val Val Asp Leu Glu Glu Glu Asn Gln Lys Leu 
            100                 105                 110         


Leu Leu Glu Asn Gln Leu Leu Arg Glu Lys Thr His Gly Leu Val Val 
        115                 120                 125             


Glu Asn Gln Glu Leu Arg Gln Arg Leu Gly Met Asp Ala Leu Val Ala 
    130                 135                 140                 


Glu Glu Glu Ala Glu Ala Lys Gly Asn Glu Val Arg Pro Val Ala Gly 
145                 150                 155                 160 


Ser Ala Glu Ser Ala Ala Gly Ala Gly Pro Val Val Thr Pro Pro Glu 
                165                 170                 175     


His Leu Pro Met Asp Ser Gly Gly Ile Asp Ser Ser Asp Ser Glu Ser 
            180                 185                 190         


Asp Ile Leu Leu Gly Ile Leu Asp Asn Leu Asp Pro Val Met Phe Phe 
        195                 200                 205             


Lys Cys Pro Ser Pro Glu Pro Ala Ser Leu Glu Glu Leu Pro Glu Val 
    210                 215                 220                 


Tyr Pro Glu Gly Pro Ser Ser Leu Pro Ala Ser Leu Ser Leu Ser Val 
225                 230                 235                 240 


Gly Thr Ser Ser Ala Lys Leu Glu Ala Ile Asn Glu Leu Ile Arg Phe 
                245                 250                 255     


Asp His Ile Tyr Thr Lys Pro Leu Val Leu Glu Ile Pro Ser Glu Thr 
            260                 265                 270         


Glu Ser Gln Ala Asn Val Val Val Lys Ile Glu Glu Ala Pro Leu Ser 
        275                 280                 285             


Pro Ser Glu Asn Asp His Pro Glu Phe Ile Val Ser Val Lys Glu Glu 
    290                 295                 300                 


Pro Val Glu Asp Asp Leu Val Pro Glu Leu Gly Ile Ser Asn Leu Leu 
305                 310                 315                 320 


Ser Ser Ser His Cys Pro Lys Pro Ser Ser Cys Leu Leu Asp Ala Tyr 
                325                 330                 335     


Ser Asp Cys Gly Tyr Gly Gly Ser Leu Ser Pro Phe Ser Asp Met Ser 
            340                 345                 350         


Ser Leu Leu Gly Val Asn His Ser Trp Glu Asp Thr Phe Ala Asn Glu 
        355                 360                 365             


Leu Phe Pro Gln Leu Ile Ser Val 
    370                 375     


<210>  10
<211>  71
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Gly Gly Arg Arg Arg Lys Lys Arg Thr Asn Asp Thr Lys His Val 
1               5                   10                  15      


Arg Phe Ala Ala Ala Val Glu Val Trp Glu Ala Asp Asp Ile Glu Arg 
            20                  25                  30          


Lys Gly Pro Trp Glu Gln Val Ala Val Asp Arg Phe Arg Phe Gln Arg 
        35                  40                  45              


Arg Ile Ala Ser Val Glu Glu Leu Leu Ser Thr Val Leu Leu Arg Gln 
    50                  55                  60                  


Lys Lys Leu Leu Glu Gln Gln 
65                  70      


<210>  11
<211>  370
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly Lys 
    290                 295                 300                 


Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr Pro 
305                 310                 315                 320 


Pro Arg Asn Ser Ala Lys Ala Lys Lys Ala Arg Gln Gly Pro Trp Glu 
                325                 330                 335     


Gln Leu Ala Arg Asp Arg Ser Arg Phe Ala Arg Arg Ile Thr Gln Ala 
            340                 345                 350         


Gln Glu Glu Leu Ser Pro Cys Leu Thr Pro Ala Ala Arg Ala Arg Ala 
        355                 360                 365             


Trp Ala 
    370 


<210>  12
<211>  352
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Gly Thr Met Lys Met Met Val His Ile Tyr Phe Val Ser Leu Leu 
1               5                   10                  15      


Leu Leu Leu Phe His Ser Tyr Ala Ile Asp Ile Glu Asn Glu Ile Thr 
            20                  25                  30          


Glu Phe Phe Asn Lys Met Arg Asp Thr Leu Pro Ala Lys Asp Ser Lys 
        35                  40                  45              


Trp Leu Asn Pro Ala Cys Met Phe Gly Gly Thr Met Asn Asp Ile Ala 
    50                  55                  60                  


Ala Leu Gly Glu Pro Phe Ser Ala Lys Cys Pro Pro Ile Glu Asp Ser 
65                  70                  75                  80  


Leu Leu Ser His Arg Tyr Lys Asp Tyr Val Val Lys Trp Glu Arg Leu 
                85                  90                  95      


Glu Lys Asn Arg Arg Arg Gln Val Ser Asn Lys Arg Val Lys His Gly 
            100                 105                 110         


Asp Leu Trp Ile Ala Asn Tyr Thr Ser Lys Phe Ser Asn Arg Arg Tyr 
        115                 120                 125             


Leu Cys Thr Val Thr Thr Lys Asn Gly Asp Cys Val Gln Gly Ile Val 
    130                 135                 140                 


Arg Ser His Ile Arg Lys Pro Pro Ser Cys Ile Pro Lys Thr Tyr Glu 
145                 150                 155                 160 


Leu Gly Thr His Asp Lys Tyr Gly Ile Asp Leu Tyr Cys Gly Ile Leu 
                165                 170                 175     


Tyr Ala Lys His Tyr Asn Asn Ile Thr Trp Tyr Lys Asp Asn Lys Glu 
            180                 185                 190         


Ile Asn Ile Asp Asp Ile Lys Tyr Ser Gln Thr Gly Lys Glu Leu Ile 
        195                 200                 205             


Ile His Asn Pro Glu Leu Glu Asp Ser Gly Arg Tyr Asp Cys Tyr Val 
    210                 215                 220                 


His Tyr Asp Asp Val Arg Ile Lys Asn Asp Ile Val Val Ser Arg Cys 
225                 230                 235                 240 


Lys Ile Leu Thr Val Ile Pro Ser Gln Asp His Arg Phe Lys Leu Ile 
                245                 250                 255     


Leu Asp Pro Lys Ile Asn Val Thr Ile Gly Glu Pro Ala Asn Ile Thr 
            260                 265                 270         


Cys Thr Ala Val Ser Thr Ser Leu Leu Ile Asp Asp Val Leu Ile Glu 
        275                 280                 285             


Trp Glu Asn Pro Ser Gly Trp Leu Ile Gly Phe Asp Phe Asp Val Tyr 
    290                 295                 300                 


Ser Val Leu Thr Ser Arg Gly Gly Ile Thr Glu Ala Thr Leu Tyr Phe 
305                 310                 315                 320 


Glu Asn Val Thr Glu Glu Tyr Ile Gly Asn Thr Tyr Lys Cys Arg Gly 
                325                 330                 335     


His Asn Tyr Tyr Phe Glu Lys Thr Leu Thr Thr Thr Val Val Leu Glu 
            340                 345                 350         


<210>  13
<211>  644
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
gcggccatcg atgtcgacaa ctaacttaag ctagcaacgg tttccctcta gcgggatcaa       60

ttccgccccc cccccctaac gttactggcc gaagccgctt ggaataaggc cggtgtgcgt      120

ttgtctatat gttattttcc accatattgc cgtcttttgg caatgtgagg gcccggaaac      180

ctggccctgt cttcttgacg agcattccta ggggtctttc ccctctcgcc aaaggaatgc      240

aaggtctgtt gaatgtcgtg aaggaagcag ttcctctgga agcttcttga agacaaacaa      300

cgtctgtagc gaccctttgc aggcagcgga accccccacc tggcgacagg tgcctctgcg      360

gccaaaagcc acgtgtataa gatacacctg caaaggcggc acaaccccag tgccacgttg      420

tgagttggat agttgtggaa agagtcaaat ggctctcctc aagcgtattc aacaaggggc      480

tgaaggatgc ccagaaggta ccccattgta tgggatctga tctggggcct cggtgcacat      540

gctttacatg tgtttagtcg aggttaaaaa aacgtctagg ccccccgaac cacggggacg      600

tggttttcct ttgaaaaaca cgataatacc aattcgccgc cacc                       644


<210>  14
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210>  15
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
atggcggatg tgtgacatac acgacgccaa aagattttgt tccagctcct gccacctccg       60

ctacgcgaga gattaaccac ccacg                                             85


<210>  16
<211>  805
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16
taataaccgg gcagggggga tcccgggtaa ttaattgaat tacatcccta cgcaaacgtt       60

ttacggccgc cggtggcgcc cgcgcccggc ggcccgtccc tggccgttgc aggccactcc      120

ggtggctccc gtcgtccccg acttccaggc ccagcagatg cagcaactca tcagcgccgt      180

aaatgcgctg acaatgagac agaacgcaat tgctcctgct aggcctccca aaccaaagaa      240

gaagaagaca accaaaccaa agccgaaaac gcagcccaag aagatcaacg gaaaaacgca      300

gcagcaaaag aagaaagaca agcaagccga caagaagaag aagaaacccg gaaaaagaga      360

aagaatgtgc atgaagattg aaaatgactg tatctatgcg gctagccaca gtaacgtagt      420

gtttccagac atgtcgggca ccgcactatc atgggtgcag aaaatctcgg gtggtctggg      480

ggccttcgca atcggcgcta tcctggtgct ggttgtggtc acttgcattg ggctccgcag      540

ataagttagg gtaggcaatg gcattgatat agcaagaaaa ttgaaaacag aaaaagttag      600

ggtaagcaat ggcatataac cataactgta taacttgtaa caaagcgcaa caagacctgc      660

gcaattggcc ccgtggtccg cctcacggaa actcggggca actcatattg acacattaat      720

tggcaataat tggaagctta cataagctta attcgacgaa taattggatt tttattttat      780

tttgcaattg gtttttaata tttcc                                            805


<210>  17
<211>  2432
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Ala Ala Lys Val His Val Asp Ile Glu Ala Asp Ser Pro Phe Ile 
1               5                   10                  15      


Lys Ser Leu Gln Lys Ala Phe Pro Ser Phe Glu Val Glu Ser Leu Gln 
            20                  25                  30          


Val Thr Pro Asn Asp His Ala Asn Ala Arg Ala Phe Ser His Leu Ala 
        35                  40                  45              


Thr Lys Leu Ile Glu Gln Glu Thr Asp Lys Asp Thr Leu Ile Leu Asp 
    50                  55                  60                  


Ile Gly Ser Ala Pro Ser Arg Arg Met Met Ser Thr His Lys Tyr His 
65                  70                  75                  80  


Cys Val Cys Pro Met Arg Ser Ala Glu Asp Pro Glu Arg Leu Val Cys 
                85                  90                  95      


Tyr Ala Lys Lys Leu Ala Ala Ala Ser Gly Lys Val Leu Asp Arg Glu 
            100                 105                 110         


Ile Ala Gly Lys Ile Thr Asp Leu Gln Thr Val Met Ala Thr Pro Asp 
        115                 120                 125             


Ala Glu Ser Pro Thr Phe Cys Leu His Thr Asp Val Thr Cys Arg Thr 
    130                 135                 140                 


Ala Ala Glu Val Ala Val Tyr Gln Asp Val Tyr Ala Val His Ala Pro 
145                 150                 155                 160 


Thr Ser Leu Tyr His Gln Ala Met Lys Gly Val Arg Thr Ala Tyr Trp 
                165                 170                 175     


Ile Gly Phe Asp Thr Thr Pro Phe Met Phe Asp Ala Leu Ala Gly Ala 
            180                 185                 190         


Tyr Pro Thr Tyr Ala Thr Asn Trp Ala Asp Glu Gln Val Leu Gln Ala 
        195                 200                 205             


Arg Asn Ile Gly Leu Cys Ala Ala Ser Leu Thr Glu Gly Arg Leu Gly 
    210                 215                 220                 


Lys Leu Ser Ile Leu Arg Lys Lys Gln Leu Lys Pro Cys Asp Thr Val 
225                 230                 235                 240 


Met Phe Ser Val Gly Ser Thr Leu Tyr Thr Glu Ser Arg Lys Leu Leu 
                245                 250                 255     


Arg Ser Trp His Leu Pro Ser Val Phe His Leu Lys Gly Lys Gln Ser 
            260                 265                 270         


Phe Thr Cys Arg Cys Asp Thr Ile Val Ser Cys Glu Gly Tyr Val Val 
        275                 280                 285             


Lys Lys Ile Thr Met Cys Pro Gly Leu Tyr Gly Lys Thr Val Gly Tyr 
    290                 295                 300                 


Ala Val Thr Tyr His Ala Glu Gly Phe Leu Val Cys Lys Thr Thr Asp 
305                 310                 315                 320 


Thr Val Lys Gly Glu Arg Val Ser Phe Pro Val Cys Thr Tyr Val Pro 
                325                 330                 335     


Ser Thr Ile Cys Asp Gln Met Thr Gly Ile Leu Ala Thr Asp Val Thr 
            340                 345                 350         


Pro Glu Asp Ala Gln Lys Leu Leu Val Gly Leu Asn Gln Arg Ile Val 
        355                 360                 365             


Val Asn Gly Arg Thr Gln Arg Asn Thr Asn Thr Met Lys Asn Tyr Leu 
    370                 375                 380                 


Leu Pro Ile Val Ala Val Ala Phe Ser Lys Trp Ala Arg Glu Tyr Lys 
385                 390                 395                 400 


Ala Asp Leu Asp Asp Glu Lys Pro Leu Gly Val Arg Glu Arg Ser Leu 
                405                 410                 415     


Thr Cys Cys Cys Leu Trp Ala Phe Lys Thr Arg Lys Met His Thr Met 
            420                 425                 430         


Tyr Lys Lys Pro Asp Thr Gln Thr Ile Val Lys Val Pro Ser Glu Phe 
        435                 440                 445             


Asn Ser Phe Val Ile Pro Ser Leu Trp Ser Thr Gly Leu Ala Ile Pro 
    450                 455                 460                 


Val Arg Ser Arg Ile Lys Met Leu Leu Ala Lys Lys Thr Lys Arg Glu 
465                 470                 475                 480 


Leu Ile Pro Val Leu Asp Ala Ser Ser Ala Arg Asp Ala Glu Gln Glu 
                485                 490                 495     


Glu Lys Glu Arg Leu Glu Ala Glu Leu Thr Arg Glu Ala Leu Pro Pro 
            500                 505                 510         


Leu Val Pro Ile Ala Pro Ala Glu Thr Gly Val Val Asp Val Asp Val 
        515                 520                 525             


Glu Glu Leu Glu Tyr His Ala Gly Ala Gly Val Val Glu Thr Pro Arg 
    530                 535                 540                 


Ser Ala Leu Lys Val Thr Ala Gln Pro Asn Asp Val Leu Leu Gly Asn 
545                 550                 555                 560 


Tyr Val Val Leu Ser Pro Gln Thr Val Leu Lys Ser Ser Lys Leu Ala 
                565                 570                 575     


Pro Val His Pro Leu Ala Glu Gln Val Lys Ile Ile Thr His Asn Gly 
            580                 585                 590         


Arg Ala Gly Arg Tyr Gln Val Asp Gly Tyr Asp Gly Arg Val Leu Leu 
        595                 600                 605             


Pro Cys Gly Ser Ala Ile Pro Val Pro Glu Phe Gln Ala Leu Ser Glu 
    610                 615                 620                 


Ser Ala Thr Met Val Tyr Asn Glu Arg Glu Phe Val Asn Arg Lys Leu 
625                 630                 635                 640 


Tyr His Ile Ala Val His Gly Pro Ser Leu Asn Thr Asp Glu Glu Asn 
                645                 650                 655     


Tyr Glu Lys Val Arg Ala Glu Arg Thr Asp Ala Glu Tyr Val Phe Asp 
            660                 665                 670         


Val Asp Lys Lys Cys Cys Val Lys Arg Glu Glu Ala Ser Gly Leu Val 
        675                 680                 685             


Leu Val Gly Glu Leu Thr Asn Pro Pro Phe His Glu Phe Ala Tyr Glu 
    690                 695                 700                 


Gly Leu Lys Ile Arg Pro Ser Ala Pro Tyr Lys Thr Thr Val Val Gly 
705                 710                 715                 720 


Val Phe Gly Val Pro Gly Ser Gly Lys Ser Ala Ile Ile Lys Ser Leu 
                725                 730                 735     


Val Thr Lys His Asp Leu Val Thr Ser Gly Lys Lys Glu Asn Cys Gln 
            740                 745                 750         


Glu Ile Val Asn Asp Val Lys Lys His Arg Gly Leu Asp Ile Gln Ala 
        755                 760                 765             


Lys Thr Val Asp Ser Ile Leu Leu Asn Gly Cys Arg Arg Ala Val Asp 
    770                 775                 780                 


Ile Leu Tyr Val Asp Glu Ala Phe Ala Cys His Ser Gly Thr Leu Leu 
785                 790                 795                 800 


Ala Leu Ile Ala Leu Val Lys Pro Arg Ser Lys Val Val Leu Cys Gly 
                805                 810                 815     


Asp Pro Lys Gln Cys Gly Phe Phe Asn Met Met Gln Leu Lys Val Asn 
            820                 825                 830         


Phe Asn His Asn Ile Cys Thr Glu Val Cys His Lys Ser Ile Ser Arg 
        835                 840                 845             


Arg Cys Thr Arg Pro Val Thr Ala Ile Val Ser Thr Leu His Tyr Gly 
    850                 855                 860                 


Gly Lys Met Arg Thr Thr Asn Pro Cys Asn Lys Pro Ile Ile Ile Asp 
865                 870                 875                 880 


Thr Thr Gly Gln Thr Lys Pro Lys Pro Gly Asp Ile Val Leu Thr Cys 
                885                 890                 895     


Phe Arg Gly Trp Val Lys Gln Leu Gln Leu Asp Tyr Arg Gly His Glu 
            900                 905                 910         


Val Met Thr Ala Ala Ala Ser Gln Gly Leu Thr Arg Lys Gly Val Tyr 
        915                 920                 925             


Ala Val Arg Gln Lys Val Asn Glu Asn Pro Leu Tyr Ala Pro Ala Ser 
    930                 935                 940                 


Glu His Val Asn Val Leu Leu Thr Arg Thr Glu Asp Arg Leu Val Trp 
945                 950                 955                 960 


Lys Thr Leu Ala Gly Asp Pro Trp Ile Lys Val Leu Ser Asn Ile Pro 
                965                 970                 975     


Gln Gly Asn Phe Thr Ala Thr Leu Glu Glu Trp Gln Glu Glu His Asp 
            980                 985                 990         


Lys Ile Met Lys Val Ile Glu Gly  Pro Ala Ala Pro Val  Asp Ala Phe 
        995                 1000                 1005             


Gln Asn  Lys Ala Asn Val Cys  Trp Ala Lys Ser Leu  Val Pro Val 
    1010                 1015                 1020             


Leu Asp  Thr Ala Gly Ile Arg  Leu Thr Ala Glu Glu  Trp Ser Thr 
    1025                 1030                 1035             


Ile Ile  Thr Ala Phe Lys Glu  Asp Arg Ala Tyr Ser  Pro Val Val 
    1040                 1045                 1050             


Ala Leu  Asn Glu Ile Cys Thr  Lys Tyr Tyr Gly Val  Asp Leu Asp 
    1055                 1060                 1065             


Ser Gly  Leu Phe Ser Ala Pro  Lys Val Ser Leu Tyr  Tyr Glu Asn 
    1070                 1075                 1080             


Asn His  Trp Asp Asn Arg Pro  Gly Gly Arg Met Tyr  Gly Phe Asn 
    1085                 1090                 1095             


Ala Ala  Thr Ala Ala Arg Leu  Glu Ala Arg His Thr  Phe Leu Lys 
    1100                 1105                 1110             


Gly Gln  Trp His Thr Gly Lys  Gln Ala Val Ile Ala  Glu Arg Lys 
    1115                 1120                 1125             


Ile Gln  Pro Leu Ser Val Leu  Asp Asn Val Ile Pro  Ile Asn Arg 
    1130                 1135                 1140             


Arg Leu  Pro His Ala Leu Val  Ala Glu Tyr Lys Thr  Val Lys Gly 
    1145                 1150                 1155             


Ser Arg  Val Glu Trp Leu Val  Asn Lys Val Arg Gly  Tyr His Val 
    1160                 1165                 1170             


Leu Leu  Val Ser Glu Tyr Asn  Leu Ala Leu Pro Arg  Arg Arg Val 
    1175                 1180                 1185             


Thr Trp  Leu Ser Pro Leu Asn  Val Thr Gly Ala Asp  Arg Cys Tyr 
    1190                 1195                 1200             


Asp Leu  Ser Leu Gly Leu Pro  Ala Asp Ala Gly Arg  Phe Asp Leu 
    1205                 1210                 1215             


Val Phe  Val Asn Ile His Thr  Glu Phe Arg Ile His  His Tyr Gln 
    1220                 1225                 1230             


Gln Cys  Val Asp His Ala Met  Lys Leu Gln Met Leu  Gly Gly Asp 
    1235                 1240                 1245             


Ala Leu  Arg Leu Leu Lys Pro  Gly Gly Ser Leu Leu  Met Arg Ala 
    1250                 1255                 1260             


Tyr Gly  Tyr Ala Asp Lys Ile  Ser Glu Ala Val Val  Ser Ser Leu 
    1265                 1270                 1275             


Ser Arg  Lys Phe Ser Ser Ala  Arg Val Leu Arg Pro  Asp Cys Val 
    1280                 1285                 1290             


Thr Ser  Asn Thr Glu Val Phe  Leu Leu Phe Ser Asn  Phe Asp Asn 
    1295                 1300                 1305             


Gly Lys  Arg Pro Ser Thr Leu  His Gln Met Asn Thr  Lys Leu Ser 
    1310                 1315                 1320             


Ala Val  Tyr Ala Gly Glu Ala  Met His Thr Ala Gly  Cys Ala Pro 
    1325                 1330                 1335             


Ser Tyr  Arg Val Lys Arg Ala  Asp Ile Ala Thr Cys  Thr Glu Ala 
    1340                 1345                 1350             


Ala Val  Val Asn Ala Ala Asn  Ala Arg Gly Thr Val  Gly Asp Gly 
    1355                 1360                 1365             


Val Cys  Arg Ala Val Ala Lys  Lys Trp Pro Ser Ala  Phe Lys Gly 
    1370                 1375                 1380             


Glu Ala  Thr Pro Val Gly Thr  Ile Lys Thr Val Met  Cys Gly Ser 
    1385                 1390                 1395             


Tyr Pro  Val Ile His Ala Val  Ala Pro Asn Phe Ser  Ala Thr Thr 
    1400                 1405                 1410             


Glu Ala  Glu Gly Asp Arg Glu  Leu Ala Ala Val Tyr  Arg Ala Val 
    1415                 1420                 1425             


Ala Ala  Glu Val Asn Arg Leu  Ser Leu Ser Ser Val  Ala Ile Pro 
    1430                 1435                 1440             


Leu Leu  Ser Thr Gly Val Phe  Ser Gly Gly Arg Asp  Arg Leu Gln 
    1445                 1450                 1455             


Gln Ser  Leu Asn His Leu Phe  Thr Ala Met Asp Ala  Thr Asp Ala 
    1460                 1465                 1470             


Asp Val  Thr Ile Tyr Cys Arg  Asp Lys Ser Trp Glu  Lys Lys Ile 
    1475                 1480                 1485             


Gln Glu  Ala Ile Asp Met Arg  Thr Ala Val Glu Leu  Leu Asn Asp 
    1490                 1495                 1500             


Asp Val  Glu Leu Thr Thr Asp  Leu Val Arg Val His  Pro Asp Ser 
    1505                 1510                 1515             


Ser Leu  Val Gly Arg Lys Gly  Tyr Ser Thr Thr Asp  Gly Ser Leu 
    1520                 1525                 1530             


Tyr Ser  Tyr Phe Glu Gly Thr  Lys Phe Asn Gln Ala  Ala Ile Asp 
    1535                 1540                 1545             


Met Ala  Glu Ile Leu Thr Leu  Trp Pro Arg Leu Gln  Glu Ala Asn 
    1550                 1555                 1560             


Glu Gln  Ile Cys Leu Tyr Ala  Leu Gly Glu Thr Met  Asp Asn Ile 
    1565                 1570                 1575             


Arg Ser  Lys Cys Pro Val Asn  Asp Ser Asp Ser Ser  Thr Pro Pro 
    1580                 1585                 1590             


Arg Thr  Val Pro Cys Leu Cys  Arg Tyr Ala Met Thr  Ala Glu Arg 
    1595                 1600                 1605             


Ile Ala  Arg Leu Arg Ser His  Gln Val Lys Ser Met  Val Val Cys 
    1610                 1615                 1620             


Ser Ser  Phe Pro Leu Pro Lys  Tyr His Val Asp Gly  Val Gln Lys 
    1625                 1630                 1635             


Val Lys  Cys Glu Lys Val Leu  Leu Phe Asp Pro Thr  Val Pro Ser 
    1640                 1645                 1650             


Val Val  Ser Pro Arg Lys Tyr  Ala Ala Ser Thr Thr  Asp His Ser 
    1655                 1660                 1665             


Asp Arg  Ser Leu Arg Gly Phe  Asp Leu Asp Trp Thr  Thr Asp Ser 
    1670                 1675                 1680             


Ser Ser  Thr Ala Ser Asp Thr  Met Ser Leu Pro Ser  Leu Gln Ser 
    1685                 1690                 1695             


Cys Asp  Ile Asp Ser Ile Tyr  Glu Pro Met Ala Pro  Ile Val Val 
    1700                 1705                 1710             


Thr Ala  Asp Val His Pro Glu  Pro Ala Gly Ile Ala  Asp Leu Ala 
    1715                 1720                 1725             


Ala Asp  Val His Pro Glu Pro  Ala Asp His Val Asp  Leu Glu Asn 
    1730                 1735                 1740             


Pro Ile  Pro Pro Pro Arg Pro  Lys Arg Ala Ala Tyr  Leu Ala Ser 
    1745                 1750                 1755             


Arg Ala  Ala Glu Arg Pro Val  Pro Ala Pro Arg Lys  Pro Thr Pro 
    1760                 1765                 1770             


Ala Pro  Arg Thr Ala Phe Arg  Asn Lys Leu Pro Leu  Thr Phe Gly 
    1775                 1780                 1785             


Asp Phe  Asp Glu His Glu Val  Asp Ala Leu Ala Ser  Gly Ile Thr 
    1790                 1795                 1800             


Phe Gly  Asp Phe Asp Asp Val  Leu Arg Leu Gly Arg  Ala Gly Ala 
    1805                 1810                 1815             


Tyr Ile  Phe Ser Ser Asp Thr  Gly Ser Gly His Leu  Gln Gln Lys 
    1820                 1825                 1830             


Ser Val  Arg Gln His Asn Leu  Gln Cys Ala Gln Leu  Asp Ala Val 
    1835                 1840                 1845             


Glu Glu  Glu Lys Met Tyr Pro  Pro Lys Leu Asp Thr  Glu Arg Glu 
    1850                 1855                 1860             


Lys Leu  Leu Leu Leu Lys Met  Gln Met His Pro Ser  Glu Ala Asn 
    1865                 1870                 1875             


Lys Ser  Arg Tyr Gln Ser Arg  Lys Val Glu Asn Met  Lys Ala Thr 
    1880                 1885                 1890             


Val Val  Asp Arg Leu Thr Ser  Gly Ala Arg Leu Tyr  Thr Gly Ala 
    1895                 1900                 1905             


Asp Val  Gly Arg Ile Pro Thr  Tyr Ala Val Arg Tyr  Pro Arg Pro 
    1910                 1915                 1920             


Val Tyr  Ser Pro Thr Val Ile  Glu Arg Phe Ser Ser  Pro Asp Val 
    1925                 1930                 1935             


Ala Ile  Ala Ala Cys Asn Glu  Tyr Leu Ser Arg Asn  Tyr Pro Thr 
    1940                 1945                 1950             


Val Ala  Ser Tyr Gln Ile Thr  Asp Glu Tyr Asp Ala  Tyr Leu Asp 
    1955                 1960                 1965             


Met Val  Asp Gly Ser Asp Ser  Cys Leu Asp Arg Ala  Thr Phe Cys 
    1970                 1975                 1980             


Pro Ala  Lys Leu Arg Cys Tyr  Pro Lys His His Ala  Tyr His Gln 
    1985                 1990                 1995             


Pro Thr  Val Arg Ser Ala Val  Pro Ser Pro Phe Gln  Asn Thr Leu 
    2000                 2005                 2010             


Gln Asn  Val Leu Ala Ala Ala  Thr Lys Arg Asn Cys  Asn Val Thr 
    2015                 2020                 2025             


Gln Met  Arg Glu Leu Pro Thr  Met Asp Ser Ala Val  Phe Asn Val 
    2030                 2035                 2040             


Glu Cys  Phe Lys Arg Tyr Ala  Cys Ser Gly Glu Tyr  Trp Glu Glu 
    2045                 2050                 2055             


Tyr Ala  Lys Gln Pro Ile Arg  Ile Thr Thr Glu Asn  Ile Thr Thr 
    2060                 2065                 2070             


Tyr Val  Thr Lys Leu Lys Gly  Pro Lys Ala Ala Ala  Leu Phe Ala 
    2075                 2080                 2085             


Lys Thr  His Asn Leu Val Pro  Leu Gln Glu Val Pro  Met Asp Arg 
    2090                 2095                 2100             


Phe Thr  Val Asp Met Lys Arg  Asp Val Lys Val Thr  Pro Gly Thr 
    2105                 2110                 2115             


Lys His  Thr Glu Glu Arg Pro  Lys Val Gln Val Ile  Gln Ala Ala 
    2120                 2125                 2130             


Glu Pro  Leu Ala Thr Ala Tyr  Leu Cys Gly Ile His  Arg Glu Leu 
    2135                 2140                 2145             


Val Arg  Arg Leu Asn Ala Val  Leu Arg Pro Asn Val  His Thr Leu 
    2150                 2155                 2160             


Phe Asp  Met Ser Ala Glu Asp  Phe Asp Ala Ile Ile  Ala Ser His 
    2165                 2170                 2175             


Phe His  Pro Gly Asp Pro Val  Leu Glu Thr Asp Ile  Ala Ser Phe 
    2180                 2185                 2190             


Asp Lys  Ser Gln Asp Asp Ser  Leu Ala Leu Thr Gly  Leu Met Ile 
    2195                 2200                 2205             


Leu Glu  Asp Leu Gly Val Asp  Gln Tyr Leu Leu Asp  Leu Ile Glu 
    2210                 2215                 2220             


Ala Ala  Phe Gly Glu Ile Ser  Ser Cys His Leu Pro  Thr Gly Thr 
    2225                 2230                 2235             


Arg Phe  Lys Phe Gly Ala Met  Met Lys Ser Gly Met  Phe Leu Thr 
    2240                 2245                 2250             


Leu Phe  Ile Asn Thr Val Leu  Asn Ile Thr Ile Ala  Ser Arg Val 
    2255                 2260                 2265             


Leu Glu  Gln Arg Leu Thr Asp  Ser Ala Cys Ala Ala  Phe Ile Gly 
    2270                 2275                 2280             


Asp Asp  Asn Ile Val His Gly  Val Ile Ser Asp Lys  Leu Met Ala 
    2285                 2290                 2295             


Glu Arg  Cys Ala Ser Trp Val  Asn Met Glu Val Lys  Ile Ile Asp 
    2300                 2305                 2310             


Ala Val  Met Gly Glu Lys Pro  Pro Tyr Phe Cys Gly  Gly Phe Ile 
    2315                 2320                 2325             


Val Phe  Asp Ser Val Thr Gln  Thr Ala Cys Arg Val  Ser Asp Pro 
    2330                 2335                 2340             


Leu Lys  Arg Leu Phe Lys Leu  Gly Lys Pro Leu Thr  Ala Glu Asp 
    2345                 2350                 2355             


Lys Gln  Asp Glu Asp Arg Arg  Arg Ala Leu Ser Asp  Glu Val Ser 
    2360                 2365                 2370             


Lys Trp  Phe Arg Thr Gly Leu  Gly Ala Glu Leu Glu  Val Ala Leu 
    2375                 2380                 2385             


Thr Ser  Arg Tyr Glu Val Glu  Gly Cys Lys Ser Ile  Leu Ile Ala 
    2390                 2395                 2400             


Met Ala  Thr Leu Ala Arg Asp  Ile Lys Ala Phe Lys  Lys Leu Arg 
    2405                 2410                 2415             


Gly Pro  Val Ile His Leu Tyr  Gly Gly Pro Arg Leu  Val Arg 
    2420                 2425                 2430         


<210>  18
<211>  125
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18
tacacagaat tctgattata gcgcactatt atagcaccat gaattacatc cctacgcaaa       60

cgttttacgg ccgccggtgg cgcccgcgcc cggcggcccg tccctggccg ttgcaggcca      120

ctccg                                                                  125


<210>  19
<211>  240
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Val Ala Pro Val Val Pro Asp Phe Gln Ala Gln Gln Met Gln Gln Leu 
1               5                   10                  15      


Ile Ser Ala Val Asn Ala Leu Thr Met Arg Gln Asn Ala Ile Ala Pro 
            20                  25                  30          


Ala Arg Pro Pro Lys Pro Lys Lys Lys Lys Thr Thr Lys Pro Lys Pro 
        35                  40                  45              


Lys Thr Gln Pro Lys Lys Ile Asn Gly Lys Thr Gln Gln Gln Lys Lys 
    50                  55                  60                  


Lys Asp Lys Gln Ala Asp Lys Lys Lys Lys Lys Pro Gly Lys Arg Glu 
65                  70                  75                  80  


Arg Met Cys Met Lys Ile Glu Asn Asp Cys Ile Phe Glu Val Lys His 
                85                  90                  95      


Glu Gly Lys Val Thr Gly Tyr Ala Cys Leu Val Gly Asp Lys Val Met 
            100                 105                 110         


Lys Pro Ala His Val Lys Gly Val Ile Asp Asn Ala Asp Leu Ala Lys 
        115                 120                 125             


Leu Ala Phe Lys Lys Ser Ser Lys Tyr Asp Leu Glu Cys Ala Gln Ile 
    130                 135                 140                 


Pro Val His Met Arg Ser Asp Ala Ser Lys Tyr Thr His Glu Lys Pro 
145                 150                 155                 160 


Glu Gly His Tyr Asn Trp His His Gly Ala Val Gln Tyr Ser Gly Gly 
                165                 170                 175     


Arg Phe Thr Ile Pro Thr Gly Ala Gly Lys Pro Gly Asp Ser Gly Arg 
            180                 185                 190         


Pro Ile Phe Asp Asn Lys Gly Arg Val Val Ala Ile Val Leu Gly Gly 
        195                 200                 205             


Ala Asn Glu Gly Ser Arg Thr Ala Leu Ser Val Val Thr Trp Asn Lys 
    210                 215                 220                 


Asp Met Val Thr Arg Val Thr Pro Glu Gly Ser Glu Glu Trp Asp Pro 
225                 230                 235                 240 


<210>  20
<211>  13
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20
gccgccacca tga                                                          13


<210>  21
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Pro Gly Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser 
        35                  40                  45              


Val Ser Phe Leu Gly Ile Asn Leu Ile His Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser 
65                  70                  75                  80  


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Thr Ile Ser Ser Val Glu Pro Glu Asp Thr Ala Asn Tyr Tyr Cys 
            100                 105                 110         


Leu Gln Ser Arg Thr Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val 
        115                 120                 125             


Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu 
    130                 135                 140                 


Gly Ser Thr Lys Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
145                 150                 155                 160 


Lys Lys Pro Gly Gly Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr 
                165                 170                 175     


Thr Phe Thr Ser Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Lys 
            180                 185                 190         


Gly Leu Glu Trp Val Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala 
        195                 200                 205             


Tyr Ala Gln Gly Phe Thr Gly Arg Phe Thr Phe Ser Ala Asp Thr Ser 
    210                 215                 220                 


Lys Ser Met Ala Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr 
225                 230                 235                 240 


Ala Val Tyr Tyr Cys Ala Leu Asp Tyr Leu Tyr Ser Leu Asp Phe Trp 
                245                 250                 255     


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln 
            260                 265                 270         


Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
        275                 280                 285             


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr 
    290                 295                 300                 


Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly 
305                 310                 315                 320 


Tyr Ile Asn Pro Ser Lys Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
                325                 330                 335     


Gly Arg Val Thr Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
            340                 345                 350         


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        355                 360                 365             


Arg Tyr Tyr Asp Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr 
    370                 375                 380                 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln 
                405                 410                 415     


Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser 
            420                 425                 430         


Cys Arg Ala Ser Ser Ser Val Ser Tyr Leu Asn Trp Tyr Gln Gln Lys 
        435                 440                 445             


Ser Gly Thr Ser Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala 
    450                 455                 460                 


Ser Gly Val Pro Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
465                 470                 475                 480 


Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Glu Ala Thr Tyr Tyr 
                485                 490                 495     


Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr Phe Gly Gln Gly Thr Lys 
            500                 505                 510         


Leu Glu Ile Lys 
        515     


<210>  22
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Ser Phe Leu 
            20                  25                  30          


Gly Ile Asn Leu Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ser Ala Ser Asn Leu Gln Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Glu Pro Glu Asp Thr Ala Asn Tyr Tyr Cys Leu Gln Ser Arg 
                85                  90                  95      


Thr Leu Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly 
            100                 105                 110         


Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys 
        115                 120                 125             


Gly Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly 
    130                 135                 140                 


Gly Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser 
145                 150                 155                 160 


Tyr Ser Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
                165                 170                 175     


Val Gly Trp Ile Asn Thr Glu Thr Arg Glu Pro Ala Tyr Ala Gln Gly 
            180                 185                 190         


Phe Thr Gly Arg Phe Thr Phe Ser Ala Asp Thr Ser Lys Ser Met Ala 
        195                 200                 205             


Tyr Leu Gln Ile Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Leu Asp Tyr Leu Tyr Ser Leu Asp Phe Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val 
                245                 250                 255     


Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser 
            260                 265                 270         


Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr Thr Met His Trp Val 
        275                 280                 285             


Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr Ile Asn Pro 
    290                 295                 300                 


Ser Lys Gly Tyr Thr Asn Tyr Asn Gln Lys Phe Lys Gly Arg Val Thr 
305                 310                 315                 320 


Met Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser 
                325                 330                 335     


Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Tyr Asp 
            340                 345                 350         


Asp His Tyr Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 
        355                 360                 365             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    370                 375                 380                 


Ser Gly Gly Gly Gly Ser Glu Ile Val Met Thr Gln Ser Pro Ala Thr 
385                 390                 395                 400 


Leu Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
                405                 410                 415     


Ser Ser Val Ser Tyr Leu Asn Trp Tyr Gln Gln Lys Ser Gly Thr Ser 
            420                 425                 430         


Pro Lys Arg Trp Ile Tyr Asp Thr Ser Lys Val Ala Ser Gly Val Pro 
        435                 440                 445             


Tyr Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
    450                 455                 460                 


Ser Ser Leu Gln Ala Glu Asp Glu Ala Thr Tyr Tyr Cys Gln Gln Trp 
465                 470                 475                 480 


Ser Ser Asn Pro Leu Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
                485                 490                 495     


<210>  23
<211>  52
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23
agacccaagc tggctagctc taaagaagcc cctgggagca cagctcatca cc               52


<210>  24
<211>  218
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
ctatgaagaa ggaaggcatc cagaccagaa accgaaaaat gtctagcaaa tccaaaaagt       60

gcaaaaaagt gcatgactca ctggaggact tccccaagaa cagctcgttt aacccggccg      120

ccctctccag acacatgtcc tccctgagcc acatctcgcc cttcagccac tccagccaca      180

tgctgaccac gcccacgccg atgcacccgc catccagc                              218


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25
agctggctag ctctaaagaa gc                                                22


<210>  26
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
tctccgaatg tctggatatt aaaggc                                            26


<210>  27
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27
aagcaacagc gtcttcgac                                                    19


<210>  28
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
atctttgtag tcagagccgc c                                                 21


