                         SEQUENCE LISTING

<110>  Benmohamed, Lbachir
 
<120>  PAN-CORONAVIRUS VACCINE COMPOSITIONS

<130>  UCI 20.06C

<160>  184   

<170>  PatentIn version 3.5

<210>  1
<211>  7096
<212>  PRT
<213>  Unknown

<220>
<223>   Severe acute respiratory syndrome coronavirus 2

<400>  1

Met Glu Ser Leu Val Pro Gly Phe Asn Glu Lys Thr His Val Gln Leu 
1               5                   10                  15      


Ser Leu Pro Val Leu Gln Val Arg Asp Val Leu Val Arg Gly Phe Gly 
            20                  25                  30          


Asp Ser Val Glu Glu Val Leu Ser Glu Ala Arg Gln His Leu Lys Asp 
        35                  40                  45              


Gly Thr Cys Gly Leu Val Glu Val Glu Lys Gly Val Leu Pro Gln Leu 
    50                  55                  60                  


Glu Gln Pro Tyr Val Phe Ile Lys Arg Ser Asp Ala Arg Thr Ala Pro 
65                  70                  75                  80  


His Gly His Val Met Val Glu Leu Val Ala Glu Leu Glu Gly Ile Gln 
                85                  90                  95      


Tyr Gly Arg Ser Gly Glu Thr Leu Gly Val Leu Val Pro His Val Gly 
            100                 105                 110         


Glu Ile Pro Val Ala Tyr Arg Lys Val Leu Leu Arg Lys Asn Gly Asn 
        115                 120                 125             


Lys Gly Ala Gly Gly His Ser Tyr Gly Ala Asp Leu Lys Ser Phe Asp 
    130                 135                 140                 


Leu Gly Asp Glu Leu Gly Thr Asp Pro Tyr Glu Asp Phe Gln Glu Asn 
145                 150                 155                 160 


Trp Asn Thr Lys His Ser Ser Gly Val Thr Arg Glu Leu Met Arg Glu 
                165                 170                 175     


Leu Asn Gly Gly Ala Tyr Thr Arg Tyr Val Asp Asn Asn Phe Cys Gly 
            180                 185                 190         


Pro Asp Gly Tyr Pro Leu Glu Cys Ile Lys Asp Leu Leu Ala Arg Ala 
        195                 200                 205             


Gly Lys Ala Ser Cys Thr Leu Ser Glu Gln Leu Asp Phe Ile Asp Thr 
    210                 215                 220                 


Lys Arg Gly Val Tyr Cys Cys Arg Glu His Glu His Glu Ile Ala Trp 
225                 230                 235                 240 


Tyr Thr Glu Arg Ser Glu Lys Ser Tyr Glu Leu Gln Thr Pro Phe Glu 
                245                 250                 255     


Ile Lys Leu Ala Lys Lys Phe Asp Thr Phe Asn Gly Glu Cys Pro Asn 
            260                 265                 270         


Phe Val Phe Pro Leu Asn Ser Ile Ile Lys Thr Ile Gln Pro Arg Val 
        275                 280                 285             


Glu Lys Lys Lys Leu Asp Gly Phe Met Gly Arg Ile Arg Ser Val Tyr 
    290                 295                 300                 


Pro Val Ala Ser Pro Asn Glu Cys Asn Gln Met Cys Leu Ser Thr Leu 
305                 310                 315                 320 


Met Lys Cys Asp His Cys Gly Glu Thr Ser Trp Gln Thr Gly Asp Phe 
                325                 330                 335     


Val Lys Ala Thr Cys Glu Phe Cys Gly Thr Glu Asn Leu Thr Lys Glu 
            340                 345                 350         


Gly Ala Thr Thr Cys Gly Tyr Leu Pro Gln Asn Ala Val Val Lys Ile 
        355                 360                 365             


Tyr Cys Pro Ala Cys His Asn Ser Glu Val Gly Pro Glu His Ser Leu 
    370                 375                 380                 


Ala Glu Tyr His Asn Glu Ser Gly Leu Lys Thr Ile Leu Arg Lys Gly 
385                 390                 395                 400 


Gly Arg Thr Ile Ala Phe Gly Gly Cys Val Phe Ser Tyr Val Gly Cys 
                405                 410                 415     


His Asn Lys Cys Ala Tyr Trp Val Pro Arg Ala Ser Ala Asn Ile Gly 
            420                 425                 430         


Cys Asn His Thr Gly Val Val Gly Glu Gly Ser Glu Gly Leu Asn Asp 
        435                 440                 445             


Asn Leu Leu Glu Ile Leu Gln Lys Glu Lys Val Asn Ile Asn Ile Val 
    450                 455                 460                 


Gly Asp Phe Lys Leu Asn Glu Glu Ile Ala Ile Ile Leu Ala Ser Phe 
465                 470                 475                 480 


Ser Ala Ser Thr Ser Ala Phe Val Glu Thr Val Lys Gly Leu Asp Tyr 
                485                 490                 495     


Lys Ala Phe Lys Gln Ile Val Glu Ser Cys Gly Asn Phe Lys Val Thr 
            500                 505                 510         


Lys Gly Lys Ala Lys Lys Gly Ala Trp Asn Ile Gly Glu Gln Lys Ser 
        515                 520                 525             


Ile Leu Ser Pro Leu Tyr Ala Phe Ala Ser Glu Ala Ala Arg Val Val 
    530                 535                 540                 


Arg Ser Ile Phe Ser Arg Thr Leu Glu Thr Ala Gln Asn Ser Val Arg 
545                 550                 555                 560 


Val Leu Gln Lys Ala Ala Ile Thr Ile Leu Asp Gly Ile Ser Gln Tyr 
                565                 570                 575     


Ser Leu Arg Leu Ile Asp Ala Met Met Phe Thr Ser Asp Leu Ala Thr 
            580                 585                 590         


Asn Asn Leu Val Val Met Ala Tyr Ile Thr Gly Gly Val Val Gln Leu 
        595                 600                 605             


Thr Ser Gln Trp Leu Thr Asn Ile Phe Gly Thr Val Tyr Glu Lys Leu 
    610                 615                 620                 


Lys Pro Val Leu Asp Trp Leu Glu Glu Lys Phe Lys Glu Gly Val Glu 
625                 630                 635                 640 


Phe Leu Arg Asp Gly Trp Glu Ile Val Lys Phe Ile Ser Thr Cys Ala 
                645                 650                 655     


Cys Glu Ile Val Gly Gly Gln Ile Val Thr Cys Ala Lys Glu Ile Lys 
            660                 665                 670         


Glu Ser Val Gln Thr Phe Phe Lys Leu Val Asn Lys Phe Leu Ala Leu 
        675                 680                 685             


Cys Ala Asp Ser Ile Ile Ile Gly Gly Ala Lys Leu Lys Ala Leu Asn 
    690                 695                 700                 


Leu Gly Glu Thr Phe Val Thr His Ser Lys Gly Leu Tyr Arg Lys Cys 
705                 710                 715                 720 


Val Lys Ser Arg Glu Glu Thr Gly Leu Leu Met Pro Leu Lys Ala Pro 
                725                 730                 735     


Lys Glu Ile Ile Phe Leu Glu Gly Glu Thr Leu Pro Thr Glu Val Leu 
            740                 745                 750         


Thr Glu Glu Val Val Leu Lys Thr Gly Asp Leu Gln Pro Leu Glu Gln 
        755                 760                 765             


Pro Thr Ser Glu Ala Val Glu Ala Pro Leu Val Gly Thr Pro Val Cys 
    770                 775                 780                 


Ile Asn Gly Leu Met Leu Leu Glu Ile Lys Asp Thr Glu Lys Tyr Cys 
785                 790                 795                 800 


Ala Leu Ala Pro Asn Met Met Val Thr Asn Asn Thr Phe Thr Leu Lys 
                805                 810                 815     


Gly Gly Ala Pro Thr Lys Val Thr Phe Gly Asp Asp Thr Val Ile Glu 
            820                 825                 830         


Val Gln Gly Tyr Lys Ser Val Asn Ile Thr Phe Glu Leu Asp Glu Arg 
        835                 840                 845             


Ile Asp Lys Val Leu Asn Glu Lys Cys Ser Ala Tyr Thr Val Glu Leu 
    850                 855                 860                 


Gly Thr Glu Val Asn Glu Phe Ala Cys Val Val Ala Asp Ala Val Ile 
865                 870                 875                 880 


Lys Thr Leu Gln Pro Val Ser Glu Leu Leu Thr Pro Leu Gly Ile Asp 
                885                 890                 895     


Leu Asp Glu Trp Ser Met Ala Thr Tyr Tyr Leu Phe Asp Glu Ser Gly 
            900                 905                 910         


Glu Phe Lys Leu Ala Ser His Met Tyr Cys Ser Phe Tyr Pro Pro Asp 
        915                 920                 925             


Glu Asp Glu Glu Glu Gly Asp Cys Glu Glu Glu Glu Phe Glu Pro Ser 
    930                 935                 940                 


Thr Gln Tyr Glu Tyr Gly Thr Glu Asp Asp Tyr Gln Gly Lys Pro Leu 
945                 950                 955                 960 


Glu Phe Gly Ala Thr Ser Ala Ala Leu Gln Pro Glu Glu Glu Gln Glu 
                965                 970                 975     


Glu Asp Trp Leu Asp Asp Asp Ser Gln Gln Thr Val Gly Gln Gln Asp 
            980                 985                 990         


Gly Ser Glu Asp Asn Gln Thr Thr  Thr Ile Gln Thr Ile  Val Glu Val 
        995                 1000                 1005             


Gln Pro  Gln Leu Glu Met Glu  Leu Thr Pro Val Val  Gln Thr Ile 
    1010                 1015                 1020             


Glu Val  Asn Ser Phe Ser Gly  Tyr Leu Lys Leu Thr  Asp Asn Val 
    1025                 1030                 1035             


Tyr Ile  Lys Asn Ala Asp Ile  Val Glu Glu Ala Lys  Lys Val Lys 
    1040                 1045                 1050             


Pro Thr  Val Val Val Asn Ala  Ala Asn Val Tyr Leu  Lys His Gly 
    1055                 1060                 1065             


Gly Gly  Val Ala Gly Ala Leu  Asn Lys Ala Thr Asn  Asn Ala Met 
    1070                 1075                 1080             


Gln Val  Glu Ser Asp Asp Tyr  Ile Ala Thr Asn Gly  Pro Leu Lys 
    1085                 1090                 1095             


Val Gly  Gly Ser Cys Val Leu  Ser Gly His Asn Leu  Ala Lys His 
    1100                 1105                 1110             


Cys Leu  His Val Val Gly Pro  Asn Val Asn Lys Gly  Glu Asp Ile 
    1115                 1120                 1125             


Gln Leu  Leu Lys Ser Ala Tyr  Glu Asn Phe Asn Gln  His Glu Val 
    1130                 1135                 1140             


Leu Leu  Ala Pro Leu Leu Ser  Ala Gly Ile Phe Gly  Ala Asp Pro 
    1145                 1150                 1155             


Ile His  Ser Leu Arg Val Cys  Val Asp Thr Val Arg  Thr Asn Val 
    1160                 1165                 1170             


Tyr Leu  Ala Val Phe Asp Lys  Asn Leu Tyr Asp Lys  Leu Val Ser 
    1175                 1180                 1185             


Ser Phe  Leu Glu Met Lys Ser  Glu Lys Gln Val Glu  Gln Lys Ile 
    1190                 1195                 1200             


Ala Glu  Ile Pro Lys Glu Glu  Val Lys Pro Phe Ile  Thr Glu Ser 
    1205                 1210                 1215             


Lys Pro  Ser Val Glu Gln Arg  Lys Gln Asp Asp Lys  Lys Ile Lys 
    1220                 1225                 1230             


Ala Cys  Val Glu Glu Val Thr  Thr Thr Leu Glu Glu  Thr Lys Phe 
    1235                 1240                 1245             


Leu Thr  Glu Asn Leu Leu Leu  Tyr Ile Asp Ile Asn  Gly Asn Leu 
    1250                 1255                 1260             


His Pro  Asp Ser Ala Thr Leu  Val Ser Asp Ile Asp  Ile Thr Phe 
    1265                 1270                 1275             


Leu Lys  Lys Asp Ala Pro Tyr  Ile Val Gly Asp Val  Val Gln Glu 
    1280                 1285                 1290             


Gly Val  Leu Thr Ala Val Val  Ile Pro Thr Lys Lys  Ala Gly Gly 
    1295                 1300                 1305             


Thr Thr  Glu Met Leu Ala Lys  Ala Leu Arg Lys Val  Pro Thr Asp 
    1310                 1315                 1320             


Asn Tyr  Ile Thr Thr Tyr Pro  Gly Gln Gly Leu Asn  Gly Tyr Thr 
    1325                 1330                 1335             


Val Glu  Glu Ala Lys Thr Val  Leu Lys Lys Cys Lys  Ser Ala Phe 
    1340                 1345                 1350             


Tyr Ile  Leu Pro Ser Ile Ile  Ser Asn Glu Lys Gln  Glu Ile Leu 
    1355                 1360                 1365             


Gly Thr  Val Ser Trp Asn Leu  Arg Glu Met Leu Ala  His Ala Glu 
    1370                 1375                 1380             


Glu Thr  Arg Lys Leu Met Pro  Val Cys Val Glu Thr  Lys Ala Ile 
    1385                 1390                 1395             


Val Ser  Thr Ile Gln Arg Lys  Tyr Lys Gly Ile Lys  Ile Gln Glu 
    1400                 1405                 1410             


Gly Val  Val Asp Tyr Gly Ala  Arg Phe Tyr Phe Tyr  Thr Ser Lys 
    1415                 1420                 1425             


Thr Thr  Val Ala Ser Leu Ile  Asn Thr Leu Asn Asp  Leu Asn Glu 
    1430                 1435                 1440             


Thr Leu  Val Thr Met Pro Leu  Gly Tyr Val Thr His  Gly Leu Asn 
    1445                 1450                 1455             


Leu Glu  Glu Ala Ala Arg Tyr  Met Arg Ser Leu Lys  Val Pro Ala 
    1460                 1465                 1470             


Thr Val  Ser Val Ser Ser Pro  Asp Ala Val Thr Ala  Tyr Asn Gly 
    1475                 1480                 1485             


Tyr Leu  Thr Ser Ser Ser Lys  Thr Pro Glu Glu His  Phe Ile Glu 
    1490                 1495                 1500             


Thr Ile  Ser Leu Ala Gly Ser  Tyr Lys Asp Trp Ser  Tyr Ser Gly 
    1505                 1510                 1515             


Gln Ser  Thr Gln Leu Gly Ile  Glu Phe Leu Lys Arg  Gly Asp Lys 
    1520                 1525                 1530             


Ser Val  Tyr Tyr Thr Ser Asn  Pro Thr Thr Phe His  Leu Asp Gly 
    1535                 1540                 1545             


Glu Val  Ile Thr Phe Asp Asn  Leu Lys Thr Leu Leu  Ser Leu Arg 
    1550                 1555                 1560             


Glu Val  Arg Thr Ile Lys Val  Phe Thr Thr Val Asp  Asn Ile Asn 
    1565                 1570                 1575             


Leu His  Thr Gln Val Val Asp  Met Ser Met Thr Tyr  Gly Gln Gln 
    1580                 1585                 1590             


Phe Gly  Pro Thr Tyr Leu Asp  Gly Ala Asp Val Thr  Lys Ile Lys 
    1595                 1600                 1605             


Pro His  Asn Ser His Glu Gly  Lys Thr Phe Tyr Val  Leu Pro Asn 
    1610                 1615                 1620             


Asp Asp  Thr Leu Arg Val Glu  Ala Phe Glu Tyr Tyr  His Thr Thr 
    1625                 1630                 1635             


Asp Pro  Ser Phe Leu Gly Arg  Tyr Met Ser Ala Leu  Asn His Thr 
    1640                 1645                 1650             


Lys Lys  Trp Lys Tyr Pro Gln  Val Asn Gly Leu Thr  Ser Ile Lys 
    1655                 1660                 1665             


Trp Ala  Asp Asn Asn Cys Tyr  Leu Ala Thr Ala Leu  Leu Thr Leu 
    1670                 1675                 1680             


Gln Gln  Ile Glu Leu Lys Phe  Asn Pro Pro Ala Leu  Gln Asp Ala 
    1685                 1690                 1695             


Tyr Tyr  Arg Ala Arg Ala Gly  Glu Ala Ala Asn Phe  Cys Ala Leu 
    1700                 1705                 1710             


Ile Leu  Ala Tyr Cys Asn Lys  Thr Val Gly Glu Leu  Gly Asp Val 
    1715                 1720                 1725             


Arg Glu  Thr Met Ser Tyr Leu  Phe Gln His Ala Asn  Leu Asp Ser 
    1730                 1735                 1740             


Cys Lys  Arg Val Leu Asn Val  Val Cys Lys Thr Cys  Gly Gln Gln 
    1745                 1750                 1755             


Gln Thr  Thr Leu Lys Gly Val  Glu Ala Val Met Tyr  Met Gly Thr 
    1760                 1765                 1770             


Leu Ser  Tyr Glu Gln Phe Lys  Lys Gly Val Gln Ile  Pro Cys Thr 
    1775                 1780                 1785             


Cys Gly  Lys Gln Ala Thr Lys  Tyr Leu Val Gln Gln  Glu Ser Pro 
    1790                 1795                 1800             


Phe Val  Met Met Ser Ala Pro  Pro Ala Gln Tyr Glu  Leu Lys His 
    1805                 1810                 1815             


Gly Thr  Phe Thr Cys Ala Ser  Glu Tyr Thr Gly Asn  Tyr Gln Cys 
    1820                 1825                 1830             


Gly His  Tyr Lys His Ile Thr  Ser Lys Glu Thr Leu  Tyr Cys Ile 
    1835                 1840                 1845             


Asp Gly  Ala Leu Leu Thr Lys  Ser Ser Glu Tyr Lys  Gly Pro Ile 
    1850                 1855                 1860             


Thr Asp  Val Phe Tyr Lys Glu  Asn Ser Tyr Thr Thr  Thr Ile Lys 
    1865                 1870                 1875             


Pro Val  Thr Tyr Lys Leu Asp  Gly Val Val Cys Thr  Glu Ile Asp 
    1880                 1885                 1890             


Pro Lys  Leu Asp Asn Tyr Tyr  Lys Lys Asp Asn Ser  Tyr Phe Thr 
    1895                 1900                 1905             


Glu Gln  Pro Ile Asp Leu Val  Pro Asn Gln Pro Tyr  Pro Asn Ala 
    1910                 1915                 1920             


Ser Phe  Asp Asn Phe Lys Phe  Val Cys Asp Asn Ile  Lys Phe Ala 
    1925                 1930                 1935             


Asp Asp  Leu Asn Gln Leu Thr  Gly Tyr Lys Lys Pro  Ala Ser Arg 
    1940                 1945                 1950             


Glu Leu  Lys Val Thr Phe Phe  Pro Asp Leu Asn Gly  Asp Val Val 
    1955                 1960                 1965             


Ala Ile  Asp Tyr Lys His Tyr  Thr Pro Ser Phe Lys  Lys Gly Ala 
    1970                 1975                 1980             


Lys Leu  Leu His Lys Pro Ile  Val Trp His Val Asn  Asn Ala Thr 
    1985                 1990                 1995             


Asn Lys  Ala Thr Tyr Lys Pro  Asn Thr Trp Cys Ile  Arg Cys Leu 
    2000                 2005                 2010             


Trp Ser  Thr Lys Pro Val Glu  Thr Ser Asn Ser Phe  Asp Val Leu 
    2015                 2020                 2025             


Lys Ser  Glu Asp Ala Gln Gly  Met Asp Asn Leu Ala  Cys Glu Asp 
    2030                 2035                 2040             


Leu Lys  Pro Val Ser Glu Glu  Val Val Glu Asn Pro  Thr Ile Gln 
    2045                 2050                 2055             


Lys Asp  Val Leu Glu Cys Asn  Val Lys Thr Thr Glu  Val Val Gly 
    2060                 2065                 2070             


Asp Ile  Ile Leu Lys Pro Ala  Asn Asn Ser Leu Lys  Ile Thr Glu 
    2075                 2080                 2085             


Glu Val  Gly His Thr Asp Leu  Met Ala Ala Tyr Val  Asp Asn Ser 
    2090                 2095                 2100             


Ser Leu  Thr Ile Lys Lys Pro  Asn Glu Leu Ser Arg  Val Leu Gly 
    2105                 2110                 2115             


Leu Lys  Thr Leu Ala Thr His  Gly Leu Ala Ala Val  Asn Ser Val 
    2120                 2125                 2130             


Pro Trp  Asp Thr Ile Ala Asn  Tyr Ala Lys Pro Phe  Leu Asn Lys 
    2135                 2140                 2145             


Val Val  Ser Thr Thr Thr Asn  Ile Val Thr Arg Cys  Leu Asn Arg 
    2150                 2155                 2160             


Val Cys  Thr Asn Tyr Met Pro  Tyr Phe Phe Thr Leu  Leu Leu Gln 
    2165                 2170                 2175             


Leu Cys  Thr Phe Thr Arg Ser  Thr Asn Ser Arg Ile  Lys Ala Ser 
    2180                 2185                 2190             


Met Pro  Thr Thr Ile Ala Lys  Asn Thr Val Lys Ser  Val Gly Lys 
    2195                 2200                 2205             


Phe Cys  Leu Glu Ala Ser Phe  Asn Tyr Leu Lys Ser  Pro Asn Phe 
    2210                 2215                 2220             


Ser Lys  Leu Ile Asn Ile Ile  Ile Trp Phe Leu Leu  Leu Ser Val 
    2225                 2230                 2235             


Cys Leu  Gly Ser Leu Ile Tyr  Ser Thr Ala Ala Leu  Gly Val Leu 
    2240                 2245                 2250             


Met Ser  Asn Leu Gly Met Pro  Ser Tyr Cys Thr Gly  Tyr Arg Glu 
    2255                 2260                 2265             


Gly Tyr  Leu Asn Ser Thr Asn  Val Thr Ile Ala Thr  Tyr Cys Thr 
    2270                 2275                 2280             


Gly Ser  Ile Pro Cys Ser Val  Cys Leu Ser Gly Leu  Asp Ser Leu 
    2285                 2290                 2295             


Asp Thr  Tyr Pro Ser Leu Glu  Thr Ile Gln Ile Thr  Ile Ser Ser 
    2300                 2305                 2310             


Phe Lys  Trp Asp Leu Thr Ala  Phe Gly Leu Val Ala  Glu Trp Phe 
    2315                 2320                 2325             


Leu Ala  Tyr Ile Leu Phe Thr  Arg Phe Phe Tyr Val  Leu Gly Leu 
    2330                 2335                 2340             


Ala Ala  Ile Met Gln Leu Phe  Phe Ser Tyr Phe Ala  Val His Phe 
    2345                 2350                 2355             


Ile Ser  Asn Ser Trp Leu Met  Trp Leu Ile Ile Asn  Leu Val Gln 
    2360                 2365                 2370             


Met Ala  Pro Ile Ser Ala Met  Val Arg Met Tyr Ile  Phe Phe Ala 
    2375                 2380                 2385             


Ser Phe  Tyr Tyr Val Trp Lys  Ser Tyr Val His Val  Val Asp Gly 
    2390                 2395                 2400             


Cys Asn  Ser Ser Thr Cys Met  Met Cys Tyr Lys Arg  Asn Arg Ala 
    2405                 2410                 2415             


Thr Arg  Val Glu Cys Thr Thr  Ile Val Asn Gly Val  Arg Arg Ser 
    2420                 2425                 2430             


Phe Tyr  Val Tyr Ala Asn Gly  Gly Lys Gly Phe Cys  Lys Leu His 
    2435                 2440                 2445             


Asn Trp  Asn Cys Val Asn Cys  Asp Thr Phe Cys Ala  Gly Ser Thr 
    2450                 2455                 2460             


Phe Ile  Ser Asp Glu Val Ala  Arg Asp Leu Ser Leu  Gln Phe Lys 
    2465                 2470                 2475             


Arg Pro  Ile Asn Pro Thr Asp  Gln Ser Ser Tyr Ile  Val Asp Ser 
    2480                 2485                 2490             


Val Thr  Val Lys Asn Gly Ser  Ile His Leu Tyr Phe  Asp Lys Ala 
    2495                 2500                 2505             


Gly Gln  Lys Thr Tyr Glu Arg  His Ser Leu Ser His  Phe Val Asn 
    2510                 2515                 2520             


Leu Asp  Asn Leu Arg Ala Asn  Asn Thr Lys Gly Ser  Leu Pro Ile 
    2525                 2530                 2535             


Asn Val  Ile Val Phe Asp Gly  Lys Ser Lys Cys Glu  Glu Ser Ser 
    2540                 2545                 2550             


Ala Lys  Ser Ala Ser Val Tyr  Tyr Ser Gln Leu Met  Cys Gln Pro 
    2555                 2560                 2565             


Ile Leu  Leu Leu Asp Gln Ala  Leu Val Ser Asp Val  Gly Asp Ser 
    2570                 2575                 2580             


Ala Glu  Val Ala Val Lys Met  Phe Asp Ala Tyr Val  Asn Thr Phe 
    2585                 2590                 2595             


Ser Ser  Thr Phe Asn Val Pro  Met Glu Lys Leu Lys  Thr Leu Val 
    2600                 2605                 2610             


Ala Thr  Ala Glu Ala Glu Leu  Ala Lys Asn Val Ser  Leu Asp Asn 
    2615                 2620                 2625             


Val Leu  Ser Thr Phe Ile Ser  Ala Ala Arg Gln Gly  Phe Val Asp 
    2630                 2635                 2640             


Ser Asp  Val Glu Thr Lys Asp  Val Val Glu Cys Leu  Lys Leu Ser 
    2645                 2650                 2655             


His Gln  Ser Asp Ile Glu Val  Thr Gly Asp Ser Cys  Asn Asn Tyr 
    2660                 2665                 2670             


Met Leu  Thr Tyr Asn Lys Val  Glu Asn Met Thr Pro  Arg Asp Leu 
    2675                 2680                 2685             


Gly Ala  Cys Ile Asp Cys Ser  Ala Arg His Ile Asn  Ala Gln Val 
    2690                 2695                 2700             


Ala Lys  Ser His Asn Ile Ala  Leu Ile Trp Asn Val  Lys Asp Phe 
    2705                 2710                 2715             


Met Ser  Leu Ser Glu Gln Leu  Arg Lys Gln Ile Arg  Ser Ala Ala 
    2720                 2725                 2730             


Lys Lys  Asn Asn Leu Pro Phe  Lys Leu Thr Cys Ala  Thr Thr Arg 
    2735                 2740                 2745             


Gln Val  Val Asn Val Val Thr  Thr Lys Ile Ala Leu  Lys Gly Gly 
    2750                 2755                 2760             


Lys Ile  Val Asn Asn Trp Leu  Lys Gln Leu Ile Lys  Val Thr Leu 
    2765                 2770                 2775             


Val Phe  Leu Phe Val Ala Ala  Ile Phe Tyr Leu Ile  Thr Pro Val 
    2780                 2785                 2790             


His Val  Met Ser Lys His Thr  Asp Phe Ser Ser Glu  Ile Ile Gly 
    2795                 2800                 2805             


Tyr Lys  Ala Ile Asp Gly Gly  Val Thr Arg Asp Ile  Ala Ser Thr 
    2810                 2815                 2820             


Asp Thr  Cys Phe Ala Asn Lys  His Ala Asp Phe Asp  Thr Trp Phe 
    2825                 2830                 2835             


Ser Gln  Arg Gly Gly Ser Tyr  Thr Asn Asp Lys Ala  Cys Pro Leu 
    2840                 2845                 2850             


Ile Ala  Ala Val Ile Thr Arg  Glu Val Gly Phe Val  Val Pro Gly 
    2855                 2860                 2865             


Leu Pro  Gly Thr Ile Leu Arg  Thr Thr Asn Gly Asp  Phe Leu His 
    2870                 2875                 2880             


Phe Leu  Pro Arg Val Phe Ser  Ala Val Gly Asn Ile  Cys Tyr Thr 
    2885                 2890                 2895             


Pro Ser  Lys Leu Ile Glu Tyr  Thr Asp Phe Ala Thr  Ser Ala Cys 
    2900                 2905                 2910             


Val Leu  Ala Ala Glu Cys Thr  Ile Phe Lys Asp Ala  Ser Gly Lys 
    2915                 2920                 2925             


Pro Val  Pro Tyr Cys Tyr Asp  Thr Asn Val Leu Glu  Gly Ser Val 
    2930                 2935                 2940             


Ala Tyr  Glu Ser Leu Arg Pro  Asp Thr Arg Tyr Val  Leu Met Asp 
    2945                 2950                 2955             


Gly Ser  Ile Ile Gln Phe Pro  Asn Thr Tyr Leu Glu  Gly Ser Val 
    2960                 2965                 2970             


Arg Val  Val Thr Thr Phe Asp  Ser Glu Tyr Cys Arg  His Gly Thr 
    2975                 2980                 2985             


Cys Glu  Arg Ser Glu Ala Gly  Val Cys Val Ser Thr  Ser Gly Arg 
    2990                 2995                 3000             


Trp Val  Leu Asn Asn Asp Tyr  Tyr Arg Ser Leu Pro  Gly Val Phe 
    3005                 3010                 3015             


Cys Gly  Val Asp Ala Val Asn  Leu Leu Thr Asn Met  Phe Thr Pro 
    3020                 3025                 3030             


Leu Ile  Gln Pro Ile Gly Ala  Leu Asp Ile Ser Ala  Ser Ile Val 
    3035                 3040                 3045             


Ala Gly  Gly Ile Val Ala Ile  Val Val Thr Cys Leu  Ala Tyr Tyr 
    3050                 3055                 3060             


Phe Met  Arg Phe Arg Arg Ala  Phe Gly Glu Tyr Ser  His Val Val 
    3065                 3070                 3075             


Ala Phe  Asn Thr Leu Leu Phe  Leu Met Ser Phe Thr  Val Leu Cys 
    3080                 3085                 3090             


Leu Thr  Pro Val Tyr Ser Phe  Leu Pro Gly Val Tyr  Ser Val Ile 
    3095                 3100                 3105             


Tyr Leu  Tyr Leu Thr Phe Tyr  Leu Thr Asn Asp Val  Ser Phe Leu 
    3110                 3115                 3120             


Ala His  Ile Gln Trp Met Val  Met Phe Thr Pro Leu  Val Pro Phe 
    3125                 3130                 3135             


Trp Ile  Thr Ile Ala Tyr Ile  Ile Cys Ile Ser Thr  Lys His Phe 
    3140                 3145                 3150             


Tyr Trp  Phe Phe Ser Asn Tyr  Leu Lys Arg Arg Val  Val Phe Asn 
    3155                 3160                 3165             


Gly Val  Ser Phe Ser Thr Phe  Glu Glu Ala Ala Leu  Cys Thr Phe 
    3170                 3175                 3180             


Leu Leu  Asn Lys Glu Met Tyr  Leu Lys Leu Arg Ser  Asp Val Leu 
    3185                 3190                 3195             


Leu Pro  Leu Thr Gln Tyr Asn  Arg Tyr Leu Ala Leu  Tyr Asn Lys 
    3200                 3205                 3210             


Tyr Lys  Tyr Phe Ser Gly Ala  Met Asp Thr Thr Ser  Tyr Arg Glu 
    3215                 3220                 3225             


Ala Ala  Cys Cys His Leu Ala  Lys Ala Leu Asn Asp  Phe Ser Asn 
    3230                 3235                 3240             


Ser Gly  Ser Asp Val Leu Tyr  Gln Pro Pro Gln Thr  Ser Ile Thr 
    3245                 3250                 3255             


Ser Ala  Val Leu Gln Ser Gly  Phe Arg Lys Met Ala  Phe Pro Ser 
    3260                 3265                 3270             


Gly Lys  Val Glu Gly Cys Met  Val Gln Val Thr Cys  Gly Thr Thr 
    3275                 3280                 3285             


Thr Leu  Asn Gly Leu Trp Leu  Asp Asp Val Val Tyr  Cys Pro Arg 
    3290                 3295                 3300             


His Val  Ile Cys Thr Ser Glu  Asp Met Leu Asn Pro  Asn Tyr Glu 
    3305                 3310                 3315             


Asp Leu  Leu Ile Arg Lys Ser  Asn His Asn Phe Leu  Val Gln Ala 
    3320                 3325                 3330             


Gly Asn  Val Gln Leu Arg Val  Ile Gly His Ser Met  Gln Asn Cys 
    3335                 3340                 3345             


Val Leu  Lys Leu Lys Val Asp  Thr Ala Asn Pro Lys  Thr Pro Lys 
    3350                 3355                 3360             


Tyr Lys  Phe Val Arg Ile Gln  Pro Gly Gln Thr Phe  Ser Val Leu 
    3365                 3370                 3375             


Ala Cys  Tyr Asn Gly Ser Pro  Ser Gly Val Tyr Gln  Cys Ala Met 
    3380                 3385                 3390             


Arg Pro  Asn Phe Thr Ile Lys  Gly Ser Phe Leu Asn  Gly Ser Cys 
    3395                 3400                 3405             


Gly Ser  Val Gly Phe Asn Ile  Asp Tyr Asp Cys Val  Ser Phe Cys 
    3410                 3415                 3420             


Tyr Met  His His Met Glu Leu  Pro Thr Gly Val His  Ala Gly Thr 
    3425                 3430                 3435             


Asp Leu  Glu Gly Asn Phe Tyr  Gly Pro Phe Val Asp  Arg Gln Thr 
    3440                 3445                 3450             


Ala Gln  Ala Ala Gly Thr Asp  Thr Thr Ile Thr Val  Asn Val Leu 
    3455                 3460                 3465             


Ala Trp  Leu Tyr Ala Ala Val  Ile Asn Gly Asp Arg  Trp Phe Leu 
    3470                 3475                 3480             


Asn Arg  Phe Thr Thr Thr Leu  Asn Asp Phe Asn Leu  Val Ala Met 
    3485                 3490                 3495             


Lys Tyr  Asn Tyr Glu Pro Leu  Thr Gln Asp His Val  Asp Ile Leu 
    3500                 3505                 3510             


Gly Pro  Leu Ser Ala Gln Thr  Gly Ile Ala Val Leu  Asp Met Cys 
    3515                 3520                 3525             


Ala Ser  Leu Lys Glu Leu Leu  Gln Asn Gly Met Asn  Gly Arg Thr 
    3530                 3535                 3540             


Ile Leu  Gly Ser Ala Leu Leu  Glu Asp Glu Phe Thr  Pro Phe Asp 
    3545                 3550                 3555             


Val Val  Arg Gln Cys Ser Gly  Val Thr Phe Gln Ser  Ala Val Lys 
    3560                 3565                 3570             


Arg Thr  Ile Lys Gly Thr His  His Trp Leu Leu Leu  Thr Ile Leu 
    3575                 3580                 3585             


Thr Ser  Leu Leu Val Leu Val  Gln Ser Thr Gln Trp  Ser Leu Phe 
    3590                 3595                 3600             


Phe Phe  Leu Tyr Glu Asn Ala  Phe Leu Pro Phe Ala  Met Gly Ile 
    3605                 3610                 3615             


Ile Ala  Met Ser Ala Phe Ala  Met Met Phe Val Lys  His Lys His 
    3620                 3625                 3630             


Ala Phe  Leu Cys Leu Phe Leu  Leu Pro Ser Leu Ala  Thr Val Ala 
    3635                 3640                 3645             


Tyr Phe  Asn Met Val Tyr Met  Pro Ala Ser Trp Val  Met Arg Ile 
    3650                 3655                 3660             


Met Thr  Trp Leu Asp Met Val  Asp Thr Ser Leu Ser  Gly Phe Lys 
    3665                 3670                 3675             


Leu Lys  Asp Cys Val Met Tyr  Ala Ser Ala Val Val  Leu Leu Ile 
    3680                 3685                 3690             


Leu Met  Thr Ala Arg Thr Val  Tyr Asp Asp Gly Ala  Arg Arg Val 
    3695                 3700                 3705             


Trp Thr  Leu Met Asn Val Leu  Thr Leu Val Tyr Lys  Val Tyr Tyr 
    3710                 3715                 3720             


Gly Asn  Ala Leu Asp Gln Ala  Ile Ser Met Trp Ala  Leu Ile Ile 
    3725                 3730                 3735             


Ser Val  Thr Ser Asn Tyr Ser  Gly Val Val Thr Thr  Val Met Phe 
    3740                 3745                 3750             


Leu Ala  Arg Gly Ile Val Phe  Met Cys Val Glu Tyr  Cys Pro Ile 
    3755                 3760                 3765             


Phe Phe  Ile Thr Gly Asn Thr  Leu Gln Cys Ile Met  Leu Val Tyr 
    3770                 3775                 3780             


Cys Phe  Leu Gly Tyr Phe Cys  Thr Cys Tyr Phe Gly  Leu Phe Cys 
    3785                 3790                 3795             


Leu Leu  Asn Arg Tyr Phe Arg  Leu Thr Leu Gly Val  Tyr Asp Tyr 
    3800                 3805                 3810             


Leu Val  Ser Thr Gln Glu Phe  Arg Tyr Met Asn Ser  Gln Gly Leu 
    3815                 3820                 3825             


Leu Pro  Pro Lys Asn Ser Ile  Asp Ala Phe Lys Leu  Asn Ile Lys 
    3830                 3835                 3840             


Leu Leu  Gly Val Gly Gly Lys  Pro Cys Ile Lys Val  Ala Thr Val 
    3845                 3850                 3855             


Gln Ser  Lys Met Ser Asp Val  Lys Cys Thr Ser Val  Val Leu Leu 
    3860                 3865                 3870             


Ser Val  Leu Gln Gln Leu Arg  Val Glu Ser Ser Ser  Lys Leu Trp 
    3875                 3880                 3885             


Ala Gln  Cys Val Gln Leu His  Asn Asp Ile Leu Leu  Ala Lys Asp 
    3890                 3895                 3900             


Thr Thr  Glu Ala Phe Glu Lys  Met Val Ser Leu Leu  Ser Val Leu 
    3905                 3910                 3915             


Leu Ser  Met Gln Gly Ala Val  Asp Ile Asn Lys Leu  Cys Glu Glu 
    3920                 3925                 3930             


Met Leu  Asp Asn Arg Ala Thr  Leu Gln Ala Ile Ala  Ser Glu Phe 
    3935                 3940                 3945             


Ser Ser  Leu Pro Ser Tyr Ala  Ala Phe Ala Thr Ala  Gln Glu Ala 
    3950                 3955                 3960             


Tyr Glu  Gln Ala Val Ala Asn  Gly Asp Ser Glu Val  Val Leu Lys 
    3965                 3970                 3975             


Lys Leu  Lys Lys Ser Leu Asn  Val Ala Lys Ser Glu  Phe Asp Arg 
    3980                 3985                 3990             


Asp Ala  Ala Met Gln Arg Lys  Leu Glu Lys Met Ala  Asp Gln Ala 
    3995                 4000                 4005             


Met Thr  Gln Met Tyr Lys Gln  Ala Arg Ser Glu Asp  Lys Arg Ala 
    4010                 4015                 4020             


Lys Val  Thr Ser Ala Met Gln  Thr Met Leu Phe Thr  Met Leu Arg 
    4025                 4030                 4035             


Lys Leu  Asp Asn Asp Ala Leu  Asn Asn Ile Ile Asn  Asn Ala Arg 
    4040                 4045                 4050             


Asp Gly  Cys Val Pro Leu Asn  Ile Ile Pro Leu Thr  Thr Ala Ala 
    4055                 4060                 4065             


Lys Leu  Met Val Val Ile Pro  Asp Tyr Asn Thr Tyr  Lys Asn Thr 
    4070                 4075                 4080             


Cys Asp  Gly Thr Thr Phe Thr  Tyr Ala Ser Ala Leu  Trp Glu Ile 
    4085                 4090                 4095             


Gln Gln  Val Val Asp Ala Asp  Ser Lys Ile Val Gln  Leu Ser Glu 
    4100                 4105                 4110             


Ile Ser  Met Asp Asn Ser Pro  Asn Leu Ala Trp Pro  Leu Ile Val 
    4115                 4120                 4125             


Thr Ala  Leu Arg Ala Asn Ser  Ala Val Lys Leu Gln  Asn Asn Glu 
    4130                 4135                 4140             


Leu Ser  Pro Val Ala Leu Arg  Gln Met Ser Cys Ala  Ala Gly Thr 
    4145                 4150                 4155             


Thr Gln  Thr Ala Cys Thr Asp  Asp Asn Ala Leu Ala  Tyr Tyr Asn 
    4160                 4165                 4170             


Thr Thr  Lys Gly Gly Arg Phe  Val Leu Ala Leu Leu  Ser Asp Leu 
    4175                 4180                 4185             


Gln Asp  Leu Lys Trp Ala Arg  Phe Pro Lys Ser Asp  Gly Thr Gly 
    4190                 4195                 4200             


Thr Ile  Tyr Thr Glu Leu Glu  Pro Pro Cys Arg Phe  Val Thr Asp 
    4205                 4210                 4215             


Thr Pro  Lys Gly Pro Lys Val  Lys Tyr Leu Tyr Phe  Ile Lys Gly 
    4220                 4225                 4230             


Leu Asn  Asn Leu Asn Arg Gly  Met Val Leu Gly Ser  Leu Ala Ala 
    4235                 4240                 4245             


Thr Val  Arg Leu Gln Ala Gly  Asn Ala Thr Glu Val  Pro Ala Asn 
    4250                 4255                 4260             


Ser Thr  Val Leu Ser Phe Cys  Ala Phe Ala Val Asp  Ala Ala Lys 
    4265                 4270                 4275             


Ala Tyr  Lys Asp Tyr Leu Ala  Ser Gly Gly Gln Pro  Ile Thr Asn 
    4280                 4285                 4290             


Cys Val  Lys Met Leu Cys Thr  His Thr Gly Thr Gly  Gln Ala Ile 
    4295                 4300                 4305             


Thr Val  Thr Pro Glu Ala Asn  Met Asp Gln Glu Ser  Phe Gly Gly 
    4310                 4315                 4320             


Ala Ser  Cys Cys Leu Tyr Cys  Arg Cys His Ile Asp  His Pro Asn 
    4325                 4330                 4335             


Pro Lys  Gly Phe Cys Asp Leu  Lys Gly Lys Tyr Val  Gln Ile Pro 
    4340                 4345                 4350             


Thr Thr  Cys Ala Asn Asp Pro  Val Gly Phe Thr Leu  Lys Asn Thr 
    4355                 4360                 4365             


Val Cys  Thr Val Cys Gly Met  Trp Lys Gly Tyr Gly  Cys Ser Cys 
    4370                 4375                 4380             


Asp Gln  Leu Arg Glu Pro Met  Leu Gln Ser Ala Asp  Ala Gln Ser 
    4385                 4390                 4395             


Phe Leu  Asn Arg Val Cys Gly  Val Ser Ala Ala Arg  Leu Thr Pro 
    4400                 4405                 4410             


Cys Gly  Thr Gly Thr Ser Thr  Asp Val Val Tyr Arg  Ala Phe Asp 
    4415                 4420                 4425             


Ile Tyr  Asn Asp Lys Val Ala  Gly Phe Ala Lys Phe  Leu Lys Thr 
    4430                 4435                 4440             


Asn Cys  Cys Arg Phe Gln Glu  Lys Asp Glu Asp Asp  Asn Leu Ile 
    4445                 4450                 4455             


Asp Ser  Tyr Phe Val Val Lys  Arg His Thr Phe Ser  Asn Tyr Gln 
    4460                 4465                 4470             


His Glu  Glu Thr Ile Tyr Asn  Leu Leu Lys Asp Cys  Pro Ala Val 
    4475                 4480                 4485             


Ala Lys  His Asp Phe Phe Lys  Phe Arg Ile Asp Gly  Asp Met Val 
    4490                 4495                 4500             


Pro His  Ile Ser Arg Gln Arg  Leu Thr Lys Tyr Thr  Met Ala Asp 
    4505                 4510                 4515             


Leu Val  Tyr Ala Leu Arg His  Phe Asp Glu Gly Asn  Cys Asp Thr 
    4520                 4525                 4530             


Leu Lys  Glu Ile Leu Val Thr  Tyr Asn Cys Cys Asp  Asp Asp Tyr 
    4535                 4540                 4545             


Phe Asn  Lys Lys Asp Trp Tyr  Asp Phe Val Glu Asn  Pro Asp Ile 
    4550                 4555                 4560             


Leu Arg  Val Tyr Ala Asn Leu  Gly Glu Arg Val Arg  Gln Ala Leu 
    4565                 4570                 4575             


Leu Lys  Thr Val Gln Phe Cys  Asp Ala Met Arg Asn  Ala Gly Ile 
    4580                 4585                 4590             


Val Gly  Val Leu Thr Leu Asp  Asn Gln Asp Leu Asn  Gly Asn Trp 
    4595                 4600                 4605             


Tyr Asp  Phe Gly Asp Phe Ile  Gln Thr Thr Pro Gly  Ser Gly Val 
    4610                 4615                 4620             


Pro Val  Val Asp Ser Tyr Tyr  Ser Leu Leu Met Pro  Ile Leu Thr 
    4625                 4630                 4635             


Leu Thr  Arg Ala Leu Thr Ala  Glu Ser His Val Asp  Thr Asp Leu 
    4640                 4645                 4650             


Thr Lys  Pro Tyr Ile Lys Trp  Asp Leu Leu Lys Tyr  Asp Phe Thr 
    4655                 4660                 4665             


Glu Glu  Arg Leu Lys Leu Phe  Asp Arg Tyr Phe Lys  Tyr Trp Asp 
    4670                 4675                 4680             


Gln Thr  Tyr His Pro Asn Cys  Val Asn Cys Leu Asp  Asp Arg Cys 
    4685                 4690                 4695             


Ile Leu  His Cys Ala Asn Phe  Asn Val Leu Phe Ser  Thr Val Phe 
    4700                 4705                 4710             


Pro Pro  Thr Ser Phe Gly Pro  Leu Val Arg Lys Ile  Phe Val Asp 
    4715                 4720                 4725             


Gly Val  Pro Phe Val Val Ser  Thr Gly Tyr His Phe  Arg Glu Leu 
    4730                 4735                 4740             


Gly Val  Val His Asn Gln Asp  Val Asn Leu His Ser  Ser Arg Leu 
    4745                 4750                 4755             


Ser Phe  Lys Glu Leu Leu Val  Tyr Ala Ala Asp Pro  Ala Met His 
    4760                 4765                 4770             


Ala Ala  Ser Gly Asn Leu Leu  Leu Asp Lys Arg Thr  Thr Cys Phe 
    4775                 4780                 4785             


Ser Val  Ala Ala Leu Thr Asn  Asn Val Ala Phe Gln  Thr Val Lys 
    4790                 4795                 4800             


Pro Gly  Asn Phe Asn Lys Asp  Phe Tyr Asp Phe Ala  Val Ser Lys 
    4805                 4810                 4815             


Gly Phe  Phe Lys Glu Gly Ser  Ser Val Glu Leu Lys  His Phe Phe 
    4820                 4825                 4830             


Phe Ala  Gln Asp Gly Asn Ala  Ala Ile Ser Asp Tyr  Asp Tyr Tyr 
    4835                 4840                 4845             


Arg Tyr  Asn Leu Pro Thr Met  Cys Asp Ile Arg Gln  Leu Leu Phe 
    4850                 4855                 4860             


Val Val  Glu Val Val Asp Lys  Tyr Phe Asp Cys Tyr  Asp Gly Gly 
    4865                 4870                 4875             


Cys Ile  Asn Ala Asn Gln Val  Ile Val Asn Asn Leu  Asp Lys Ser 
    4880                 4885                 4890             


Ala Gly  Phe Pro Phe Asn Lys  Trp Gly Lys Ala Arg  Leu Tyr Tyr 
    4895                 4900                 4905             


Asp Ser  Met Ser Tyr Glu Asp  Gln Asp Ala Leu Phe  Ala Tyr Thr 
    4910                 4915                 4920             


Lys Arg  Asn Val Ile Pro Thr  Ile Thr Gln Met Asn  Leu Lys Tyr 
    4925                 4930                 4935             


Ala Ile  Ser Ala Lys Asn Arg  Ala Arg Thr Val Ala  Gly Val Ser 
    4940                 4945                 4950             


Ile Cys  Ser Thr Met Thr Asn  Arg Gln Phe His Gln  Lys Leu Leu 
    4955                 4960                 4965             


Lys Ser  Ile Ala Ala Thr Arg  Gly Ala Thr Val Val  Ile Gly Thr 
    4970                 4975                 4980             


Ser Lys  Phe Tyr Gly Gly Trp  His Asn Met Leu Lys  Thr Val Tyr 
    4985                 4990                 4995             


Ser Asp  Val Glu Asn Pro His  Leu Met Gly Trp Asp  Tyr Pro Lys 
    5000                 5005                 5010             


Cys Asp  Arg Ala Met Pro Asn  Met Leu Arg Ile Met  Ala Ser Leu 
    5015                 5020                 5025             


Val Leu  Ala Arg Lys His Thr  Thr Cys Cys Ser Leu  Ser His Arg 
    5030                 5035                 5040             


Phe Tyr  Arg Leu Ala Asn Glu  Cys Ala Gln Val Leu  Ser Glu Met 
    5045                 5050                 5055             


Val Met  Cys Gly Gly Ser Leu  Tyr Val Lys Pro Gly  Gly Thr Ser 
    5060                 5065                 5070             


Ser Gly  Asp Ala Thr Thr Ala  Tyr Ala Asn Ser Val  Phe Asn Ile 
    5075                 5080                 5085             


Cys Gln  Ala Val Thr Ala Asn  Val Asn Ala Leu Leu  Ser Thr Asp 
    5090                 5095                 5100             


Gly Asn  Lys Ile Ala Asp Lys  Tyr Val Arg Asn Leu  Gln His Arg 
    5105                 5110                 5115             


Leu Tyr  Glu Cys Leu Tyr Arg  Asn Arg Asp Val Asp  Thr Asp Phe 
    5120                 5125                 5130             


Val Asn  Glu Phe Tyr Ala Tyr  Leu Arg Lys His Phe  Ser Met Met 
    5135                 5140                 5145             


Ile Leu  Ser Asp Asp Ala Val  Val Cys Phe Asn Ser  Thr Tyr Ala 
    5150                 5155                 5160             


Ser Gln  Gly Leu Val Ala Ser  Ile Lys Asn Phe Lys  Ser Val Leu 
    5165                 5170                 5175             


Tyr Tyr  Gln Asn Asn Val Phe  Met Ser Glu Ala Lys  Cys Trp Thr 
    5180                 5185                 5190             


Glu Thr  Asp Leu Thr Lys Gly  Pro His Glu Phe Cys  Ser Gln His 
    5195                 5200                 5205             


Thr Met  Leu Val Lys Gln Gly  Asp Asp Tyr Val Tyr  Leu Pro Tyr 
    5210                 5215                 5220             


Pro Asp  Pro Ser Arg Ile Leu  Gly Ala Gly Cys Phe  Val Asp Asp 
    5225                 5230                 5235             


Ile Val  Lys Thr Asp Gly Thr  Leu Met Ile Glu Arg  Phe Val Ser 
    5240                 5245                 5250             


Leu Ala  Ile Asp Ala Tyr Pro  Leu Thr Lys His Pro  Asn Gln Glu 
    5255                 5260                 5265             


Tyr Ala  Asp Val Phe His Leu  Tyr Leu Gln Tyr Ile  Arg Lys Leu 
    5270                 5275                 5280             


His Asp  Glu Leu Thr Gly His  Met Leu Asp Met Tyr  Ser Val Met 
    5285                 5290                 5295             


Leu Thr  Asn Asp Asn Thr Ser  Arg Tyr Trp Glu Pro  Glu Phe Tyr 
    5300                 5305                 5310             


Glu Ala  Met Tyr Thr Pro His  Thr Val Leu Gln Ala  Val Gly Ala 
    5315                 5320                 5325             


Cys Val  Leu Cys Asn Ser Gln  Thr Ser Leu Arg Cys  Gly Ala Cys 
    5330                 5335                 5340             


Ile Arg  Arg Pro Phe Leu Cys  Cys Lys Cys Cys Tyr  Asp His Val 
    5345                 5350                 5355             


Ile Ser  Thr Ser His Lys Leu  Val Leu Ser Val Asn  Pro Tyr Val 
    5360                 5365                 5370             


Cys Asn  Ala Pro Gly Cys Asp  Val Thr Asp Val Thr  Gln Leu Tyr 
    5375                 5380                 5385             


Leu Gly  Gly Met Ser Tyr Tyr  Cys Lys Ser His Lys  Pro Pro Ile 
    5390                 5395                 5400             


Ser Phe  Pro Leu Cys Ala Asn  Gly Gln Val Phe Gly  Leu Tyr Lys 
    5405                 5410                 5415             


Asn Thr  Cys Val Gly Ser Asp  Asn Val Thr Asp Phe  Asn Ala Ile 
    5420                 5425                 5430             


Ala Thr  Cys Asp Trp Thr Asn  Ala Gly Asp Tyr Ile  Leu Ala Asn 
    5435                 5440                 5445             


Thr Cys  Thr Glu Arg Leu Lys  Leu Phe Ala Ala Glu  Thr Leu Lys 
    5450                 5455                 5460             


Ala Thr  Glu Glu Thr Phe Lys  Leu Ser Tyr Gly Ile  Ala Thr Val 
    5465                 5470                 5475             


Arg Glu  Val Leu Ser Asp Arg  Glu Leu His Leu Ser  Trp Glu Val 
    5480                 5485                 5490             


Gly Lys  Pro Arg Pro Pro Leu  Asn Arg Asn Tyr Val  Phe Thr Gly 
    5495                 5500                 5505             


Tyr Arg  Val Thr Lys Asn Ser  Lys Val Gln Ile Gly  Glu Tyr Thr 
    5510                 5515                 5520             


Phe Glu  Lys Gly Asp Tyr Gly  Asp Ala Val Val Tyr  Arg Gly Thr 
    5525                 5530                 5535             


Thr Thr  Tyr Lys Leu Asn Val  Gly Asp Tyr Phe Val  Leu Thr Ser 
    5540                 5545                 5550             


His Thr  Val Met Pro Leu Ser  Ala Pro Thr Leu Val  Pro Gln Glu 
    5555                 5560                 5565             


His Tyr  Val Arg Ile Thr Gly  Leu Tyr Pro Thr Leu  Asn Ile Ser 
    5570                 5575                 5580             


Asp Glu  Phe Ser Ser Asn Val  Ala Asn Tyr Gln Lys  Val Gly Met 
    5585                 5590                 5595             


Gln Lys  Tyr Ser Thr Leu Gln  Gly Pro Pro Gly Thr  Gly Lys Ser 
    5600                 5605                 5610             


His Phe  Ala Ile Gly Leu Ala  Leu Tyr Tyr Pro Ser  Ala Arg Ile 
    5615                 5620                 5625             


Val Tyr  Thr Ala Cys Ser His  Ala Ala Val Asp Ala  Leu Cys Glu 
    5630                 5635                 5640             


Lys Ala  Leu Lys Tyr Leu Pro  Ile Asp Lys Cys Ser  Arg Ile Ile 
    5645                 5650                 5655             


Pro Ala  Arg Ala Arg Val Glu  Cys Phe Asp Lys Phe  Lys Val Asn 
    5660                 5665                 5670             


Ser Thr  Leu Glu Gln Tyr Val  Phe Cys Thr Val Asn  Ala Leu Pro 
    5675                 5680                 5685             


Glu Thr  Thr Ala Asp Ile Val  Val Phe Asp Glu Ile  Ser Met Ala 
    5690                 5695                 5700             


Thr Asn  Tyr Asp Leu Ser Val  Val Asn Ala Arg Leu  Arg Ala Lys 
    5705                 5710                 5715             


His Tyr  Val Tyr Ile Gly Asp  Pro Ala Gln Leu Pro  Ala Pro Arg 
    5720                 5725                 5730             


Thr Leu  Leu Thr Lys Gly Thr  Leu Glu Pro Glu Tyr  Phe Asn Ser 
    5735                 5740                 5745             


Val Cys  Arg Leu Met Lys Thr  Ile Gly Pro Asp Met  Phe Leu Gly 
    5750                 5755                 5760             


Thr Cys  Arg Arg Cys Pro Ala  Glu Ile Val Asp Thr  Val Ser Ala 
    5765                 5770                 5775             


Leu Val  Tyr Asp Asn Lys Leu  Lys Ala His Lys Asp  Lys Ser Ala 
    5780                 5785                 5790             


Gln Cys  Phe Lys Met Phe Tyr  Lys Gly Val Ile Thr  His Asp Val 
    5795                 5800                 5805             


Ser Ser  Ala Ile Asn Arg Pro  Gln Ile Gly Val Val  Arg Glu Phe 
    5810                 5815                 5820             


Leu Thr  Arg Asn Pro Ala Trp  Arg Lys Ala Val Phe  Ile Ser Pro 
    5825                 5830                 5835             


Tyr Asn  Ser Gln Asn Ala Val  Ala Ser Lys Ile Leu  Gly Leu Pro 
    5840                 5845                 5850             


Thr Gln  Thr Val Asp Ser Ser  Gln Gly Ser Glu Tyr  Asp Tyr Val 
    5855                 5860                 5865             


Ile Phe  Thr Gln Thr Thr Glu  Thr Ala His Ser Cys  Asn Val Asn 
    5870                 5875                 5880             


Arg Phe  Asn Val Ala Ile Thr  Arg Ala Lys Val Gly  Ile Leu Cys 
    5885                 5890                 5895             


Ile Met  Ser Asp Arg Asp Leu  Tyr Asp Lys Leu Gln  Phe Thr Ser 
    5900                 5905                 5910             


Leu Glu  Ile Pro Arg Arg Asn  Val Ala Thr Leu Gln  Ala Glu Asn 
    5915                 5920                 5925             


Val Thr  Gly Leu Phe Lys Asp  Cys Ser Lys Val Ile  Thr Gly Leu 
    5930                 5935                 5940             


His Pro  Thr Gln Ala Pro Thr  His Leu Ser Val Asp  Thr Lys Phe 
    5945                 5950                 5955             


Lys Thr  Glu Gly Leu Cys Val  Asp Ile Pro Gly Ile  Pro Lys Asp 
    5960                 5965                 5970             


Met Thr  Tyr Arg Arg Leu Ile  Ser Met Met Gly Phe  Lys Met Asn 
    5975                 5980                 5985             


Tyr Gln  Val Asn Gly Tyr Pro  Asn Met Phe Ile Thr  Arg Glu Glu 
    5990                 5995                 6000             


Ala Ile  Arg His Val Arg Ala  Trp Ile Gly Phe Asp  Val Glu Gly 
    6005                 6010                 6015             


Cys His  Ala Thr Arg Glu Ala  Val Gly Thr Asn Leu  Pro Leu Gln 
    6020                 6025                 6030             


Leu Gly  Phe Ser Thr Gly Val  Asn Leu Val Ala Val  Pro Thr Gly 
    6035                 6040                 6045             


Tyr Val  Asp Thr Pro Asn Asn  Thr Asp Phe Ser Arg  Val Ser Ala 
    6050                 6055                 6060             


Lys Pro  Pro Pro Gly Asp Gln  Phe Lys His Leu Ile  Pro Leu Met 
    6065                 6070                 6075             


Tyr Lys  Gly Leu Pro Trp Asn  Val Val Arg Ile Lys  Ile Val Gln 
    6080                 6085                 6090             


Met Leu  Ser Asp Thr Leu Lys  Asn Leu Ser Asp Arg  Val Val Phe 
    6095                 6100                 6105             


Val Leu  Trp Ala His Gly Phe  Glu Leu Thr Ser Met  Lys Tyr Phe 
    6110                 6115                 6120             


Val Lys  Ile Gly Pro Glu Arg  Thr Cys Cys Leu Cys  Asp Arg Arg 
    6125                 6130                 6135             


Ala Thr  Cys Phe Ser Thr Ala  Ser Asp Thr Tyr Ala  Cys Trp His 
    6140                 6145                 6150             


His Ser  Ile Gly Phe Asp Tyr  Val Tyr Asn Pro Phe  Met Ile Asp 
    6155                 6160                 6165             


Val Gln  Gln Trp Gly Phe Thr  Gly Asn Leu Gln Ser  Asn His Asp 
    6170                 6175                 6180             


Leu Tyr  Cys Gln Val His Gly  Asn Ala His Val Ala  Ser Cys Asp 
    6185                 6190                 6195             


Ala Ile  Met Thr Arg Cys Leu  Ala Val His Glu Cys  Phe Val Lys 
    6200                 6205                 6210             


Arg Val  Asp Trp Thr Ile Glu  Tyr Pro Ile Ile Gly  Asp Glu Leu 
    6215                 6220                 6225             


Lys Ile  Asn Ala Ala Cys Arg  Lys Val Gln His Met  Val Val Lys 
    6230                 6235                 6240             


Ala Ala  Leu Leu Ala Asp Lys  Phe Pro Val Leu His  Asp Ile Gly 
    6245                 6250                 6255             


Asn Pro  Lys Ala Ile Lys Cys  Val Pro Gln Ala Asp  Val Glu Trp 
    6260                 6265                 6270             


Lys Phe  Tyr Asp Ala Gln Pro  Cys Ser Asp Lys Ala  Tyr Lys Ile 
    6275                 6280                 6285             


Glu Glu  Leu Phe Tyr Ser Tyr  Ala Thr His Ser Asp  Lys Phe Thr 
    6290                 6295                 6300             


Asp Gly  Val Cys Leu Phe Trp  Asn Cys Asn Val Asp  Arg Tyr Pro 
    6305                 6310                 6315             


Ala Asn  Ser Ile Val Cys Arg  Phe Asp Thr Arg Val  Leu Ser Asn 
    6320                 6325                 6330             


Leu Asn  Leu Pro Gly Cys Asp  Gly Gly Ser Leu Tyr  Val Asn Lys 
    6335                 6340                 6345             


His Ala  Phe His Thr Pro Ala  Phe Asp Lys Ser Ala  Phe Val Asn 
    6350                 6355                 6360             


Leu Lys  Gln Leu Pro Phe Phe  Tyr Tyr Ser Asp Ser  Pro Cys Glu 
    6365                 6370                 6375             


Ser His  Gly Lys Gln Val Val  Ser Asp Ile Asp Tyr  Val Pro Leu 
    6380                 6385                 6390             


Lys Ser  Ala Thr Cys Ile Thr  Arg Cys Asn Leu Gly  Gly Ala Val 
    6395                 6400                 6405             


Cys Arg  His His Ala Asn Glu  Tyr Arg Leu Tyr Leu  Asp Ala Tyr 
    6410                 6415                 6420             


Asn Met  Met Ile Ser Ala Gly  Phe Ser Leu Trp Val  Tyr Lys Gln 
    6425                 6430                 6435             


Phe Asp  Thr Tyr Asn Leu Trp  Asn Thr Phe Thr Arg  Leu Gln Ser 
    6440                 6445                 6450             


Leu Glu  Asn Val Ala Phe Asn  Val Val Asn Lys Gly  His Phe Asp 
    6455                 6460                 6465             


Gly Gln  Gln Gly Glu Val Pro  Val Ser Ile Ile Asn  Asn Thr Val 
    6470                 6475                 6480             


Tyr Thr  Lys Val Asp Gly Val  Asp Val Glu Leu Phe  Glu Asn Lys 
    6485                 6490                 6495             


Thr Thr  Leu Pro Val Asn Val  Ala Phe Glu Leu Trp  Ala Lys Arg 
    6500                 6505                 6510             


Asn Ile  Lys Pro Val Pro Glu  Val Lys Ile Leu Asn  Asn Leu Gly 
    6515                 6520                 6525             


Val Asp  Ile Ala Ala Asn Thr  Val Ile Trp Asp Tyr  Lys Arg Asp 
    6530                 6535                 6540             


Ala Pro  Ala His Ile Ser Thr  Ile Gly Val Cys Ser  Met Thr Asp 
    6545                 6550                 6555             


Ile Ala  Lys Lys Pro Thr Glu  Thr Ile Cys Ala Pro  Leu Thr Val 
    6560                 6565                 6570             


Phe Phe  Asp Gly Arg Val Asp  Gly Gln Val Asp Leu  Phe Arg Asn 
    6575                 6580                 6585             


Ala Arg  Asn Gly Val Leu Ile  Thr Glu Gly Ser Val  Lys Gly Leu 
    6590                 6595                 6600             


Gln Pro  Ser Val Gly Pro Lys  Gln Ala Ser Leu Asn  Gly Val Thr 
    6605                 6610                 6615             


Leu Ile  Gly Glu Ala Val Lys  Thr Gln Phe Asn Tyr  Tyr Lys Lys 
    6620                 6625                 6630             


Val Asp  Gly Val Val Gln Gln  Leu Pro Glu Thr Tyr  Phe Thr Gln 
    6635                 6640                 6645             


Ser Arg  Asn Leu Gln Glu Phe  Lys Pro Arg Ser Gln  Met Glu Ile 
    6650                 6655                 6660             


Asp Phe  Leu Glu Leu Ala Met  Asp Glu Phe Ile Glu  Arg Tyr Lys 
    6665                 6670                 6675             


Leu Glu  Gly Tyr Ala Phe Glu  His Ile Val Tyr Gly  Asp Phe Ser 
    6680                 6685                 6690             


His Ser  Gln Leu Gly Gly Leu  His Leu Leu Ile Gly  Leu Ala Lys 
    6695                 6700                 6705             


Arg Phe  Lys Glu Ser Pro Phe  Glu Leu Glu Asp Phe  Ile Pro Met 
    6710                 6715                 6720             


Asp Ser  Thr Val Lys Asn Tyr  Phe Ile Thr Asp Ala  Gln Thr Gly 
    6725                 6730                 6735             


Ser Ser  Lys Cys Val Cys Ser  Val Ile Asp Leu Leu  Leu Asp Asp 
    6740                 6745                 6750             


Phe Val  Glu Ile Ile Lys Ser  Gln Asp Leu Ser Val  Val Ser Lys 
    6755                 6760                 6765             


Val Val  Lys Val Thr Ile Asp  Tyr Thr Glu Ile Ser  Phe Met Leu 
    6770                 6775                 6780             


Trp Cys  Lys Asp Gly His Val  Glu Thr Phe Tyr Pro  Lys Leu Gln 
    6785                 6790                 6795             


Ser Ser  Gln Ala Trp Gln Pro  Gly Val Ala Met Pro  Asn Leu Tyr 
    6800                 6805                 6810             


Lys Met  Gln Arg Met Leu Leu  Glu Lys Cys Asp Leu  Gln Asn Tyr 
    6815                 6820                 6825             


Gly Asp  Ser Ala Thr Leu Pro  Lys Gly Ile Met Met  Asn Val Ala 
    6830                 6835                 6840             


Lys Tyr  Thr Gln Leu Cys Gln  Tyr Leu Asn Thr Leu  Thr Leu Ala 
    6845                 6850                 6855             


Val Pro  Tyr Asn Met Arg Val  Ile His Phe Gly Ala  Gly Ser Asp 
    6860                 6865                 6870             


Lys Gly  Val Ala Pro Gly Thr  Ala Val Leu Arg Gln  Trp Leu Pro 
    6875                 6880                 6885             


Thr Gly  Thr Leu Leu Val Asp  Ser Asp Leu Asn Asp  Phe Val Ser 
    6890                 6895                 6900             


Asp Ala  Asp Ser Thr Leu Ile  Gly Asp Cys Ala Thr  Val His Thr 
    6905                 6910                 6915             


Ala Asn  Lys Trp Asp Leu Ile  Ile Ser Asp Met Tyr  Asp Pro Lys 
    6920                 6925                 6930             


Thr Lys  Asn Val Thr Lys Glu  Asn Asp Ser Lys Glu  Gly Phe Phe 
    6935                 6940                 6945             


Thr Tyr  Ile Cys Gly Phe Ile  Gln Gln Lys Leu Ala  Leu Gly Gly 
    6950                 6955                 6960             


Ser Val  Ala Ile Lys Ile Thr  Glu His Ser Trp Asn  Ala Asp Leu 
    6965                 6970                 6975             


Tyr Lys  Leu Met Gly His Phe  Ala Trp Trp Thr Ala  Phe Val Thr 
    6980                 6985                 6990             


Asn Val  Asn Ala Ser Ser Ser  Glu Ala Phe Leu Ile  Gly Cys Asn 
    6995                 7000                 7005             


Tyr Leu  Gly Lys Pro Arg Glu  Gln Ile Asp Gly Tyr  Val Met His 
    7010                 7015                 7020             


Ala Asn  Tyr Ile Phe Trp Arg  Asn Thr Asn Pro Ile  Gln Leu Ser 
    7025                 7030                 7035             


Ser Tyr  Ser Leu Phe Asp Met  Ser Lys Phe Pro Leu  Lys Leu Arg 
    7040                 7045                 7050             


Gly Thr  Ala Val Met Ser Leu  Lys Glu Gly Gln Ile  Asn Asp Met 
    7055                 7060                 7065             


Ile Leu  Ser Leu Leu Ser Lys  Gly Arg Leu Ile Ile  Arg Glu Asn 
    7070                 7075                 7080             


Asn Arg  Val Val Ile Ser Ser  Asp Val Leu Val Asn  Asn 
    7085                 7090                 7095     


<210>  2
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Met Val Glu Leu Val Ala Glu Leu 
1               5                   


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Tyr Leu Ala Thr Ala Leu Leu Thr Leu 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Cys Leu Glu Ala Ser Phe Asn Tyr Leu 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Trp Leu Met Trp Leu Ile Ile Asn Leu 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Leu Pro Gly Val Phe Cys Gly Val 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Leu Leu Asn Lys Glu Met Tyr Leu 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Met Trp Ala Leu Ile Ile Ser Val 
1               5                   


<210>  9
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  9

Tyr Leu Ala Ser Gly Gly Gln Pro Ile 
1               5                   


<210>  10
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  10

Lys Leu Ser Tyr Gly Ile Ala Thr Val 
1               5                   


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Tyr Leu Asp Ala Tyr Asn Met Met Ile 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  12

Leu Leu Leu Asp Asp Phe Val Glu Ile 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Val Phe Leu Val Leu Leu Pro Leu 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Ile Ile Ala Tyr Thr Met Ser Leu 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Leu Asn Thr Leu Val Lys Gln Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  16

Val Leu Asn Asp Ile Leu Ser Arg Leu 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Leu Gln Ser Leu Gln Thr Tyr Val 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Ile Ala Gly Leu Ile Ala Ile Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  19

Phe Leu Ala Phe Val Val Phe Leu Leu 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Phe Leu Leu Val Thr Leu Ala Ile Leu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Phe Leu Leu Asn Lys Glu Met Tyr Leu 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Phe Leu Trp Leu Leu Trp Pro Val 
1               5                   


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Leu Met Trp Leu Ser Tyr Phe Ile 
1               5                   


<210>  24
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  24

His Leu Val Asp Phe Gln Val Thr Ile 
1               5                   


<210>  25
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  25

Ile Ile Phe Trp Phe Ser Leu Glu Leu 
1               5                   


<210>  26
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  26

Tyr Val Val Asp Asp Pro Cys Pro Ile 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Tyr Ile Asp Ile Gly Asn Tyr Thr Val 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Tyr Ile Asn Val Phe Ala Phe Pro Phe 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Asn Val Phe Ala Phe Pro Phe Thr Ile 
1               5                   


<210>  30
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  30

Val Met Val Glu Leu Val Ala Glu 
1               5               


<210>  31
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  31

Leu Ala Thr Ala Leu Leu Thr Leu 
1               5               


<210>  32
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  32

Cys Leu Glu Ala Ser Phe Asn Tyr 
1               5               


<210>  33
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  33

Leu Met Trp Leu Ile Ile Asn Leu 
1               5               


<210>  34
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  34

Ser Leu Pro Gly Val Phe Cys Gly 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  35

Leu Leu Asn Lys Glu Met Tyr Leu 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Met Trp Ala Leu Ile Ile Ser 
1               5               


<210>  37
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Ala Ser Gly Gly Gln Pro Ile 
1               5               


<210>  38
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Leu Ser Tyr Gly Ile Ala Thr 
1               5               


<210>  39
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  39

Leu Asp Ala Tyr Asn Met Met Ile 
1               5               


<210>  40
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  40

Leu Leu Leu Asp Asp Phe Val Glu 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  41

Val Phe Leu Val Leu Leu Pro Leu 
1               5               


<210>  42
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  42

Ser Ile Ile Ala Tyr Thr Met Ser 
1               5               


<210>  43
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  43

Leu Asn Thr Leu Val Lys Gln Leu 
1               5               


<210>  44
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  44

Val Leu Asn Asp Ile Leu Ser Arg 
1               5               


<210>  45
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Gln Ser Leu Gln Thr Tyr Val 
1               5               


<210>  46
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  46

Phe Ile Ala Gly Leu Ile Ala Ile 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Ala Phe Val Val Phe Leu Leu 
1               5               


<210>  48
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  48

Phe Leu Leu Val Thr Leu Ala Ile 
1               5               


<210>  49
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Leu Asn Lys Glu Met Tyr Leu 
1               5               


<210>  50
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  50

Ile Phe Leu Trp Leu Leu Trp Pro 
1               5               


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Leu Met Trp Leu Ser Tyr Phe Ile 
1               5               


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

His Leu Val Asp Phe Gln Val Thr 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Ile Phe Trp Phe Ser Leu Glu Leu 
1               5               


<210>  54
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  54

Tyr Val Val Asp Asp Pro Cys Pro 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  55

Ile Asp Ile Gly Asn Tyr Thr Val 
1               5               


<210>  56
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  56

Tyr Ile Asn Val Phe Ala Phe Pro 
1               5               


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Val Phe Ala Phe Pro Phe Thr Ile 
1               5               


<210>  58
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  58

Lys Ser Ala Phe Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  59

Glu Ser Pro Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  60

Pro Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg Lys 
1               5                   10                  15  


<210>  61
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  61

Arg Ile Lys Val Gln Met Leu Ser Asp Thr Leu Lys Asn Leu 
1               5                   10                  


<210>  62
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  62

Leu Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp 
1               5                   10                  15  


<210>  63
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  63

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser 
1               5                   10              


<210>  64
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  64

Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala Ile Leu 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  65

Phe Leu Leu Val Thr Leu Ala Ile Leu Thr Ala Leu Arg Leu Cys 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  66

Leu Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  67

Ala Glu Ile Leu Leu Ile Ile Met Arg Thr Phe Lys Val Ser Ile 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Lys Ile Ile Leu Phe Leu Ala Leu Ile Thr Leu Ala Thr Cys 
1               5                   10                  15  


<210>  69
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  69

Ile Ile Phe Leu Ala Leu Ile Thr Leu Ala Thr Cys Glu Leu 
1               5                   10                  


<210>  70
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  70

Ser Pro Ile Phe Leu Ile Val Ala Ala Ile Val Phe Ile Thr Leu 
1               5                   10                  15  


<210>  71
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  71

Asp Phe Tyr Leu Cys Phe Leu Ala Phe Leu Leu Phe Leu Val Leu 
1               5                   10                  15  


<210>  72
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Lys Phe Leu Val Phe Leu Gly Ile Ile Thr Thr Val Ala Ala 
1               5                   10                  15  


<210>  73
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  73

Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe 
1               5                   10                  15      


<210>  74
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  74

Lys Ser Ala Phe Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu 
1               5                   10                  


<210>  75
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  75

Glu Ser Pro Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr 
1               5                   10                  


<210>  76
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  76

Pro Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg 
1               5                   10                  


<210>  77
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  77

Arg Ile Lys Val Gln Met Leu Ser Asp Thr Leu Lys Asn 
1               5                   10              


<210>  78
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  78

Leu Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu 
1               5                   10                  


<210>  79
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser 
1               5                   10          


<210>  80
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  80

Phe Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala Ile 
1               5                   10                  


<210>  81
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  81

Phe Leu Leu Val Thr Leu Ala Ile Leu Thr Ala Leu Arg Leu 
1               5                   10                  


<210>  82
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  82

Leu Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly 
1               5                   10                  


<210>  83
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  83

Ala Glu Ile Leu Leu Ile Ile Met Arg Thr Phe Lys Val Ser 
1               5                   10                  


<210>  84
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Lys Ile Ile Leu Phe Leu Ala Leu Ile Thr Leu Ala Thr 
1               5                   10                  


<210>  85
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  85

Ile Ile Phe Leu Ala Leu Ile Thr Leu Ala Thr Cys Glu 
1               5                   10              


<210>  86
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  86

Ser Pro Ile Phe Leu Ile Val Ala Ala Ile Val Phe Ile Thr 
1               5                   10                  


<210>  87
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  87

Asp Phe Tyr Leu Cys Phe Leu Ala Phe Leu Leu Phe Leu Val 
1               5                   10                  


<210>  88
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Lys Phe Leu Val Phe Leu Gly Ile Ile Thr Thr Val Ala 
1               5                   10                  


<210>  89
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  89

Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp 
1               5                   10                  15  


<210>  90
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Ala Phe Tyr Ile Leu Pro Ser Ile Ile Ser Asn Glu Lys 
1               5                   10                  


<210>  91
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  91

Ser Pro Phe Val Met Met Ser Ala Pro Pro Ala Gln Tyr Glu 
1               5                   10                  


<210>  92
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  92

Asn Met Leu Arg Ile Met Ala Ser Leu Val Leu Ala Arg Lys 
1               5                   10                  


<210>  93
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  93

Ile Lys Val Gln Met Leu Ser Asp Thr Leu Lys Asn Leu 
1               5                   10              


<210>  94
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  94

Asp Ala Tyr Asn Met Met Ile Ser Ala Gly Phe Ser Leu Trp 
1               5                   10                  


<210>  95
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  95

Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser 
1               5                   10          


<210>  96
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  96

Leu Ala Phe Val Val Phe Leu Leu Val Thr Leu Ala Ile Leu 
1               5                   10                  


<210>  97
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  97

Leu Leu Val Thr Leu Ala Ile Leu Thr Ala Leu Arg Leu Cys 
1               5                   10                  


<210>  98
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  98

Ser Tyr Tyr Lys Leu Gly Ala Ser Gln Arg Val Ala Gly Asp 
1               5                   10                  


<210>  99
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Ile Leu Leu Ile Ile Met Arg Thr Phe Lys Val Ser Ile 
1               5                   10                  


<210>  100
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  100

Lys Ile Ile Leu Phe Leu Ala Leu Ile Thr Leu Ala Thr Cys 
1               5                   10                  


<210>  101
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  101

Ile Phe Leu Ala Leu Ile Thr Leu Ala Thr Cys Glu Leu 
1               5                   10              


<210>  102
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  102

Pro Ile Phe Leu Ile Val Ala Ala Ile Val Phe Ile Thr Leu 
1               5                   10                  


<210>  103
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  103

Phe Tyr Leu Cys Phe Leu Ala Phe Leu Leu Phe Leu Val Leu 
1               5                   10                  


<210>  104
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  104

Lys Phe Leu Val Phe Leu Gly Ile Ile Thr Thr Val Ala Ala 
1               5                   10                  


<210>  105
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  105

Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp Asp Phe 
1               5                   10                  15  


<210>  106
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  106

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr 
            20                  25  


<210>  107
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  107

Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
1               5                   10                  15      


Gly Thr Lys Arg Phe Asp Asn 
            20              


<210>  108
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  108

Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
1               5                   10                  15      


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
            20                  25                  30      


<210>  109
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  109

Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn 
1               5                   10                  15      


Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
            20                  25                  30          


Trp Arg Val Tyr Ser Thr Gly Ser 
        35                  40  


<210>  110
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  110

Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
1               5                   10                  15      


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
            20                  25                  30          


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
        35                  40                  45              


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
    50                  55                  60                  


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
65                  70                  75  


<210>  111
<211>  62
<212>  PRT
<213>  Homo sapiens

<400>  111

Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
1               5                   10                  15      


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
            20                  25                  30          


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
        35                  40                  45              


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Glu 
    50                  55                  60          


<210>  112
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  112

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
1               5                   10                  15      


Thr Lys Leu Asn Asp Leu Cys Phe Thr 
            20                  25  


<210>  113
<211>  35
<212>  PRT
<213>  Homo sapiens

<400>  113

Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
1               5                   10                  15      


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
            20                  25                  30          


Cys Val Ala 
        35  


<210>  114
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  114

Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe 
1               5                   10                  15      


Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val 
            20                  25                  30          


Asp Leu Gly Asp Ile Ser Gly Ile 
        35                  40  


<210>  115
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  115

Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
1               5                   10                  15      


Ile Glu 
        


<210>  116
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  116

Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
1               5                   10                  15      


Tyr Arg Phe Asn Gly Ile 
            20          


<210>  117
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  117

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly 
            20              


<210>  118
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  118

Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
1               5                   10                  15      


Gly Thr Lys Arg Phe 
            20      


<210>  119
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  119

Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
1               5                   10                  15      


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr 
            20                  25                  


<210>  120
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  120

Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn 
1               5                   10                  15      


Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
            20                  25                  30          


Trp Arg Val Tyr Ser Thr 
        35              


<210>  121
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  121

Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
1               5                   10                  15      


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
            20                  25                  30          


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp 
        35                  40                  45              


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
    50                  55                  60                  


Thr Pro Cys Ser Phe Gly Gly Val Ser 
65                  70              


<210>  122
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  122

Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
1               5                   10                  15      


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
            20                  25                  30          


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
        35                  40                  45              


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro 
    50                  55                  60  


<210>  123
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  123

Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
1               5                   10                  15      


Thr Lys Leu Asn Asp Leu Cys 
            20              


<210>  124
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  124

Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala 
1               5                   10                  15      


Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn 
            20                  25                  30          


Cys 
    


<210>  125
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  125

Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe 
1               5                   10                  15      


Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val 
            20                  25                  30          


Asp Leu Gly Asp Ile Ser 
        35              


<210>  126
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  126

Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe 
1               5                   10                  15      


<210>  127
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  127

Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
1               5                   10                  15      


Tyr Arg Phe Asn 
            20  


<210>  128
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  128

Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn 
1               5                   10                  15      


Ser Phe Thr Arg Gly Val Tyr 
            20              


<210>  129
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  129

Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
1               5                   10                  15      


Lys Arg Phe Asp Asn 
            20      


<210>  130
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  130

Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
1               5                   10                  15      


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
            20                  25                  


<210>  131
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  131

Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr 
1               5                   10                  15      


Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg 
            20                  25                  30          


Val Tyr Ser Thr Gly Ser 
        35              


<210>  132
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  132

Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
1               5                   10                  15      


Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys 
            20                  25                  30          


Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr 
        35                  40                  45              


Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    50                  55                  60                  


Cys Ser Phe Gly Gly Val Ser Val Ile 
65                  70              


<210>  133
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  133

Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg 
1               5                   10                  15      


Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr 
            20                  25                  30          


Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr 
        35                  40                  45              


Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Glu 
    50                  55                  60  


<210>  134
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  134

Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys 
1               5                   10                  15      


Leu Asn Asp Leu Cys Phe Thr 
            20              


<210>  135
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  135

Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg 
1               5                   10                  15      


Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val 
            20                  25                  30          


Ala 
    


<210>  136
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  136

Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu 
1               5                   10                  15      


Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
            20                  25                  30          


Gly Asp Ile Ser Gly Ile 
        35              


<210>  137
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  137

Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu 
1               5                   10                  15      


<210>  138
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  138

Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg 
1               5                   10                  15      


Phe Asn Gly Ile 
            20  


<210>  139
<211>  5912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Vaccine Candidate 1

<400>  139
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttggagaata     1740

aactagtatt cttctggtcc ccacagactc agagagaacc cgccaccatg ttcgtgttcc     1800

tggtgctgct gcccctggtg agcagccagt gcgtgaactt caccaccagg acccagctgc     1860

cccccgccta caccaacagc ttcaccaggg gcgtgtacta ccccgacaag gtgttcagga     1920

gcagcgtgct gcacagcacc caggacctgt tcctgccctt cttcagcaac gtgacctggt     1980

tccacgccat ccacgtgagc ggcaccaacg gcaccaagag gttcgacaac cccgtgctgc     2040

ccttcaacga cggcgtgtac ttcgccagca ccgagaagag caacatcatc aggggctgga     2100

tcttcggcac caccctggac agcaagaccc agagcctgct gatcgtgaac aacgccacca     2160

acgtggtgat caaggtgtgc gagttccagt tctgcaacga ccccttcctg ggcgtgtact     2220

accacaagaa caacaagagc tggatggaga gcgagttcag ggtgtacagc agcgccaaca     2280

actgcacctt cgagtacgtg agccagccct tcctgatgga cctggagggc aagcagggca     2340

acttcaagaa cctgagggag ttcgtgttca agaacatcga cggctacttc aagatctaca     2400

gcaagcacac ccccatcaac ctggtgaggg acctgcccca gggcttcagc gccctggagc     2460

ccctggtgga cctgcccatc ggcatcaaca tcaccaggtt ccagaccctg ctggccctgc     2520

acaggagcta cctgaccccc ggcgacagca gcagcggctg gaccgccggc gccgccgcct     2580

actacgtggg ctacctgcag cccaggacct tcctgctgaa gtacaacgag aacggcacca     2640

tcaccgacgc cgtggactgc gccctggacc ccctgagcga gaccaagtgc accctgaaga     2700

gcttcaccgt ggagaagggc atctaccaga ccagcaactt cagggtgcag cccaccgaga     2760

gcatcgtgag gttccccaac atcaccaacc tgtgcccctt cagcgagatc ttcaacgcca     2820

ccaagttcag cagcgtgtac gcctgggaca ggaggaagat caacaactgc gtggccgact     2880

acagcttcct gtacaacagc gccagcttca gcaccttcaa gtgctacggc gtgagcctga     2940

acaagctgaa cgacctgtgc ttcaccaacg tgtacgccga cagcttcgtg atcaggggcg     3000

accaggtgaa gcagatcgcc cccggccaga ccggcaacat cgccgactac aactacaagc     3060

tgcccgacga cttcaccggc tgcgtgatcg cctggaacag caagaagctg gacagcaagg     3120

tggtgggcaa ccacaagtac aggttcaggt tcttcaggaa gagcaacctg aagcccttcg     3180

agagggacat cagcaccgag atctaccagg tgggcaacaa gccctgcaag ggcgccaagg     3240

gcctgaactg ctacctgccc ctgaagagct acggcttcca gcccacctac ggcgtgggct     3300

accagcccca cagggtggtg gtgctgagct tcgagctgct gcacgccagc gccaccgtgt     3360

gcggccccaa gaagagcacc aacctggtga agaacaagtg cgtgaacttc aacttcaacg     3420

gcctgaccgg caccggcgtg ctgaccgaga gcaacaagaa gttcctgccc ttccagcagt     3480

tcggcaggga catcgccgac accaccgacg ccgtgaggga cccccagacc ctggagatcc     3540

tggacatcac cccctgcagc ttcggcggcg tgagcgtgat cacccccggc accaacacca     3600

gcaaccaggt ggccgtgctg taccaggacg tgaactgcac cgaggtgccc gtggccatcc     3660

acgccgacca gctgaccccc acctggaggg tgtacagcac cggcagcaac gtgttccaga     3720

ccagggccgg ctgcctgatc ggcgccgagc acgtgaacaa cagctacgag tgcgacatcc     3780

ccatcggcgc cggcatctgc gccagctacc agacccagac caacagcccc aggagggcca     3840

ggagcgtggc cagccagagc atcatcgcct acaccatgag cctgggcgcc gagaacagcg     3900

tggcctacag caacaacagc atcgccatcc ccaccaactt caccatcagc gtgaccaccg     3960

agatcctgcc cgtgagcatg accaagacca gcgtggactg caccatgtac atctgcggcg     4020

acagcaccga gtgcagcaac ctgctgctgc agtacggcag cttctgcacc cagctgaaca     4080

gggccctgac cggcatcgcc gtggagcagg acaagaacac ccaggaggtg ttcgcccagg     4140

tgaagcagat ctacaagacc ccccccatca agtacttcgg cggcttcaac ttcagccaga     4200

tcctgcccga ccccagcaag cccagcaaga ggagcttcat cgaggacctg ctgttcaaca     4260

aggtgaccct ggccgacgcc ggcttcatca agcagtacgg cgactgcctg ggcgacatcg     4320

ccgccaggga cctgatctgc gcccagaagt tcaacggcct gaccgtgctg ccccccctgc     4380

tgaccgacga gatgatcgcc cagtacacca gcgccctgct ggccggcacc atcaccagcg     4440

gctggacctt cggcgccggc gccgccctgc agatcccctt cgccatgcag atggcctaca     4500

ggttcaacgg catcggcgtg acccagaacg tgctgtacga gaaccagaag ctgatcgcca     4560

accagttcaa cagcgccatc ggcaagatcc aggacagcct gagcagcacc gccagcgccc     4620

tgggcaagct gcaggacgtg gtgaaccaga acgcccaggc cctgaacacc ctggtgaagc     4680

agctgagcag caacttcggc gccatcagca gcgtgctgaa cgacatcctg agcaggctgg     4740

acaaggtgga ggccgaggtg cagatcgaca ggctgatcac cggcaggctg cagagcctgc     4800

agacctacgt gacccagcag ctgatcaggg ccgccgagat cagggccagc gccaacctgg     4860

ccgccaccaa gatgagcgag tgcgtgctgg gccagagcaa gagggtggac ttctgcggca     4920

agggctacca cctgatgagc ttcccccaga gcgcccccca cggcgtggtg ttcctgcacg     4980

tgacctacgt gcccgcccag gagaagaact tcaccaccgc ccccgccatc tgccacgacg     5040

gcaaggccca cttccccagg gagggcgtgt tcgtgagcaa cggcacccac tggttcgtga     5100

cccagaggaa cttctacgag ccccagatca tcaccaccga caacaccttc gtgagcggca     5160

actgcgacgt ggtgatcggc atcgtgaaca acaccgtgta cgaccccctg cagcccgagc     5220

tggacagctt caaggaggag ctggacaagt acttcaagaa ccacaccagc cccgacgtgg     5280

acctgggcga catcagcggc atcaacgcca gcgtggtgaa catccagaag gagatcgaca     5340

ggctgaacga ggtggccaag aacctgaacg agagcctgat cgacctgcag gagctgggca     5400

agtacgagca gtacatcaag tggccctggt acatctggct gggcttcatc gccggcctga     5460

tcgccatcgt gatggtgacc atcatgctgt gctgcatgac cagctgctgc agctgcctga     5520

agggctgctg cagctgcggc agctgctgca agttcgacga ggacgacagc gagcccgtgc     5580

tgaagggcgt gaagctgcac tacacctgac tcgagctggt actgcatgca cgcaatgcta     5640

gctgcccctt tcccgtcctg ggtaccccga gtctcccccg acctcgggtc ccaggtatgc     5700

tcccacctcc acctgcccca ctcaccacct ctgctagttc cagacacctc ccaagcacgc     5760

agcaatgcag ctcaaaacgc ttagcctagc cacaccccca cgggaaacag cagtgattaa     5820

cctttagcaa taaacgaaag tttaactaag ctatactaac cccagggttg gtcaatttcg     5880

tgccagccac accctggagc tagcaaaaaa aa                                   5912


<210>  140
<211>  5912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Vaccine Candidate 2

<400>  140
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttggagaata     1740

aactagtatt cttctggtcc ccacagactc agagagaacc cgccaccatg ttcgtgttcc     1800

tggtgctgct gcccctggtg agcagccagt gcgtgaactt caccaccagg acccagctgc     1860

cccccgccta caccaacagc ttcaccaggg gcgtgtacta ccccgacaag gtgttcagga     1920

gcagcgtgct gcacagcacc caggacctgt tcctgccctt cttcagcaac gtgacctggt     1980

tccacgccat ccacgtgagc ggcaccaacg gcaccaagag gttcgacaac cccgtgctgc     2040

ccttcaacga cggcgtgtac ttcgccagca ccgagaagag caacatcatc aggggctgga     2100

tcttcggcac caccctggac agcaagaccc agagcctgct gatcgtgaac aacgccacca     2160

acgtggtgat caaggtgtgc gagttccagt tctgcaacga ccccttcctg ggcgtgtact     2220

accacaagaa caacaagagc tggatggaga gcgagttcag ggtgtacagc agcgccaaca     2280

actgcacctt cgagtacgtg agccagccct tcctgatgga cctggagggc aagcagggca     2340

acttcaagaa cctgagggag ttcgtgttca agaacatcga cggctacttc aagatctaca     2400

gcaagcacac ccccatcaac ctggtgaggg acctgcccca gggcttcagc gccctggagc     2460

ccctggtgga cctgcccatc ggcatcaaca tcaccaggtt ccagaccctg ctggccctgc     2520

acaggagcta cctgaccccc ggcgacagca gcagcggctg gaccgccggc gccgccgcct     2580

actacgtggg ctacctgcag cccaggacct tcctgctgaa gtacaacgag aacggcacca     2640

tcaccgacgc cgtggactgc gccctggacc ccctgagcga gaccaagtgc accctgaaga     2700

gcttcaccgt ggagaagggc atctaccaga ccagcaactt cagggtgcag cccaccgaga     2760

gcatcgtgag gttccccaac atcaccaacc tgtgcccctt cagcgagatc ttcaacgcca     2820

ccaagttcag cagcgtgtac gcctgggaca ggaggaagat caacaactgc gtggccgact     2880

acagcttcct gtacaacagc gccagcttca gcaccttcaa gtgctacggc gtgagcctga     2940

acaagctgaa cgacctgtgc ttcaccaacg tgtacgccga cagcttcgtg atcaggggcg     3000

accaggtgaa gcagatcgcc cccggccaga ccggcaacat cgccgactac aactacaagc     3060

tgcccgacga cttcaccggc tgcgtgatcg cctggaacag caagaagctg gacagcaagg     3120

tggtgggcaa ccacaagtac aggttcaggt tcttcaggaa gagcaacctg aagcccttcg     3180

agagggacat cagcaccgag atctaccagg tgggcaacaa gccctgcaag ggcgccaagg     3240

gcctgaactg ctacctgccc ctgaagagct acggcttcca gcccacctac ggcgtgggct     3300

accagcccca cagggtggtg gtgctgagct tcgagctgct gcacgccagc gccaccgtgt     3360

gcggccccaa gaagagcacc aacctggtga agaacaagtg cgtgaacttc aacttcaacg     3420

gcctgaccgg caccggcgtg ctgaccgaga gcaacaagaa gttcctgccc ttccagcagt     3480

tcggcaggga catcgccgac accaccgacg ccgtgaggga cccccagacc ctggagatcc     3540

tggacatcac cccctgcagc ttcggcggcg tgagcgtgat cacccccggc accaacacca     3600

gcaaccaggt ggccgtgctg taccaggacg tgaactgcac cgaggtgccc gtggccatcc     3660

acgccgacca gctgaccccc acctggaggg tgtacagcac cggcagcaac gtgttccaga     3720

ccagggccgg ctgcctgatc ggcgccgagc acgtgaacaa cagctacgag tgcgacatcc     3780

ccatcggcgc cggcatctgc gccagctacc agacccagac caacagcccc ggcagcgcca     3840

gcagcgtggc cagccagagc atcatcgcct acaccatgag cctgggcgcc gagaacagcg     3900

tggcctacag caacaacagc atcgccatcc ccaccaactt caccatcagc gtgaccaccg     3960

agatcctgcc cgtgagcatg accaagacca gcgtggactg caccatgtac atctgcggcg     4020

acagcaccga gtgcagcaac ctgctgctgc agtacggcag cttctgcacc cagctgaaca     4080

gggccctgac cggcatcgcc gtggagcagg acaagaacac ccaggaggtg ttcgcccagg     4140

tgaagcagat ctacaagacc ccccccatca agtacttcgg cggcttcaac ttcagccaga     4200

tcctgcccga ccccagcaag cccagcaaga ggagccccat cgaggacctg ctgttcaaca     4260

aggtgaccct ggccgacgcc ggcttcatca agcagtacgg cgactgcctg ggcgacatcg     4320

ccgccaggga cctgatctgc gcccagaagt tcaacggcct gaccgtgctg ccccccctgc     4380

tgaccgacga gatgatcgcc cagtacacca gcgccctgct ggccggcacc atcaccagcg     4440

gctggacctt cggcgccggc cccgccctgc agatcccctt ccccatgcag atggcctaca     4500

ggttcaacgg catcggcgtg acccagaacg tgctgtacga gaaccagaag ctgatcgcca     4560

accagttcaa cagcgccatc ggcaagatcc aggacagcct gagcagcacc cccagcgccc     4620

tgggcaagct gcaggacgtg gtgaaccaga acgcccaggc cctgaacacc ctggtgaagc     4680

agctgagcag caacttcggc gccatcagca gcgtgctgaa cgacatcctg agcaggctgg     4740

acccccccga ggccgaggtg cagatcgaca ggctgatcac cggcaggctg cagagcctgc     4800

agacctacgt gacccagcag ctgatcaggg ccgccgagat cagggccagc gccaacctgg     4860

ccgccaccaa gatgagcgag tgcgtgctgg gccagagcaa gagggtggac ttctgcggca     4920

agggctacca cctgatgagc ttcccccaga gcgcccccca cggcgtggtg ttcctgcacg     4980

tgacctacgt gcccgcccag gagaagaact tcaccaccgc ccccgccatc tgccacgacg     5040

gcaaggccca cttccccagg gagggcgtgt tcgtgagcaa cggcacccac tggttcgtga     5100

cccagaggaa cttctacgag ccccagatca tcaccaccga caacaccttc gtgagcggca     5160

actgcgacgt ggtgatcggc atcgtgaaca acaccgtgta cgaccccctg cagcccgagc     5220

tggacagctt caaggaggag ctggacaagt acttcaagaa ccacaccagc cccgacgtgg     5280

acctgggcga catcagcggc atcaacgcca gcgtggtgaa catccagaag gagatcgaca     5340

ggctgaacga ggtggccaag aacctgaacg agagcctgat cgacctgcag gagctgggca     5400

agtacgagca gtacatcaag tggccctggt acatctggct gggcttcatc gccggcctga     5460

tcgccatcgt gatggtgacc atcatgctgt gctgcatgac cagctgctgc agctgcctga     5520

agggctgctg cagctgcggc agctgctgca agttcgacga ggacgacagc gagcccgtgc     5580

tgaagggcgt gaagctgcac tacacctgac tcgagctggt actgcatgca cgcaatgcta     5640

gctgcccctt tcccgtcctg ggtaccccga gtctcccccg acctcgggtc ccaggtatgc     5700

tcccacctcc acctgcccca ctcaccacct ctgctagttc cagacacctc ccaagcacgc     5760

agcaatgcag ctcaaaacgc ttagcctagc cacaccccca cgggaaacag cagtgattaa     5820

cctttagcaa taaacgaaag tttaactaag ctatactaac cccagggttg gtcaatttcg     5880

tgccagccac accctggagc tagcaaaaaa aa                                   5912


<210>  141
<211>  4927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthesized Vaccine Candidate 3

<400>  141
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttggagaata     1740

aactagtatt cttctggtcc ccacagactc agagagaacc cgccaccatg ttcgtgttcc     1800

tggtgctgct gcccctggtg agcagccagt gcgtggaggc cgccgccaag aagagctacg     1860

gcttccagcc cacctacgcc gcctacgtgg tgggcaacca caagtacagg ttcgccgcct     1920

actaccaggt gggcaacaag ccctgcaagg ccgcctactg cgtgatcgcc tggaacagca     1980

agaaggccgc ctacaagggc gccaagggcc tgaactgcta cgccgcctac agccagtgcg     2040

tgaacttcac caccagggcc gcctacaaca tcgccgacta caactacaag ctggccgcct     2100

actacctgcc cctgaagagc tacggcttcg ccgcctacaa gtgctacggc gtgagcctga     2160

acaaggccgc ctactgcgtg atcgcctgga acagcaagaa ggccgcctac atctacaaga     2220

ccccccccat caagtacgcc gcctactgcg tggccgacta cagcttcctg tacgccgcct     2280

acagcgtgta cgcctgggac aggaggaagg ccgcctacag gttcttcagg aagagcaacc     2340

tgaaggccgc ctacgacatc agcaccgaga tctaccaggt ggccgcctac taccagcccc     2400

acagggtggt ggtgctggcc gcctacgtgg tgggcaacca caagtacagg ttcgccgcct     2460

acttcgtgat caggggcgac caggtgaagg ccgcctacaa cgccaccaag ttcagcagcg     2520

tgtacgccgc ctactaccag gtgggcaaca agccctgcaa ggccgcctac aacgccacca     2580

agttcagcag cgtgtacgcc gcctacttcg tgatcagggg cgaccaggtg aaggccgcct     2640

acaagggcgc caagggcctg aactgctacg ccgcctacaa cctgtgcccc ttcagcgaga     2700

tcttcgccgc ctacgccagc gccaccgtgg gaagcggagc cacgaacttc tctctgttaa     2760

agcaagcagg agatgttgaa gaaaaccccg ggcctcaact gctacctgcc cctgaagagc     2820

tacggcttcc agcccaccta cggccccggc cccggcggca accacaagta caggttcagg     2880

ttcttcagga agagcaacct gggccccggc cccggcccct tcgagaggga catcagcacc     2940

gagatctacc aggtgggcaa cggccccggc cccggcaaga agctggacag caaggtggtg     3000

ggcaaccaca agtacaggtt cggccccggc cccggcaagg gcctgaactg ctacctgccc     3060

ctgaagagct acggcttcca gggccccggc cccggcctgg tgctgctgcc cctggtgagc     3120

agccagtgcg tgaacttcac cggccccggc cccggcaggg gcgaccaggt gaagcagatc     3180

gcccccggcc agaccggcaa cggccccggc cccggcagcg ccagcttcag caccttcaag     3240

tgctacggcg tgagcctgaa cggccccggc cccggcaagc tggacagcaa ggtggtgggc     3300

aaccacaagt acaggttcag gggccccggc cccggcttcg cccaggtgaa gcagatctac     3360

aagacccccc ccatcaagta cggccccggc cccggcgccg actacagctt cctgtacaac     3420

agcgccagct tcagcacctt cggccccggc cccggcgcca ccaagttcag cagcgtgtac     3480

gcctgggaca ggaggaagat cggccccggc cccggccccc acagggtggt ggtgctgagc     3540

ttcgagctgc tgcacgccag cggccccggc cccggcttcg agagggacat cagcaccgag     3600

atctaccagg tgggcaacaa gggccccggc cccggcgcca agggcctgaa ctgctacctg     3660

cccctgaaga gctacggctt cggccccggc cccggcagca tcgtgaggtt ccccaacatc     3720

accaacctgt gccccttcag cggccccggc cccggcaaca actgcgtggc cgactacagc     3780

ttcctgtaca acagcgccag cggccccggc cccggcaagg gcgccaaggg cctgaactgc     3840

tacctgcccc tgaagagcta cggccccggc cccggcctgt gccccttcag cgagatcttc     3900

aacgccacca agttcagcag cggaagcgga gccacgaact tctctctgtt aaagcaagca     3960

ggagatgttg aagaaaaccc cgggcctctg cgtgaacttc accaccagga cccagctgcc     4020

ccccgcctac accaacagct tcaccagggg cgtgtactac aagaagaaca tcaccaacct     4080

gtgccccttc agcgagatct tcaacgccac caagttcagc agcgtgtacg cctgggacag     4140

gaggaagaag atcaacaact gcgtggccga ctacagcttc ctgtacaaca gcgccagctt     4200

cagcaccttc aagtgctacg gcgtgagcct gaacaagctg aacgacctga agaagagggg     4260

cgaccaggtg aagcagatcg cccccggcca gaccggcaac atcgccgaca agaagaagaa     4320

gctggacagc aaggtggtgg gcaaccacaa gtacaggttc aggttcttca ggaagagcaa     4380

cctgaagccc ttcgagaggg acatcagcac cgagatctac caggtgggca acaagccctg     4440

caagggcaag aagacctacg gcgtgggcta caagaagctg cacgccagcg ccaccgtgtg     4500

cggccccaag aagagcacca acctgaagaa ggtgaagcag atctacaaga ccccccccat     4560

caagtacttc ggcggcttca acttcagcca gatcctgccc gaccccagca agcccagcaa     4620

gtgactcgag ctggtactgc atgcacgcaa tgctagctgc ccctttcccg tcctgggtac     4680

cccgagtctc ccccgacctc gggtcccagg tatgctccca cctccacctg ccccactcac     4740

cacctctgct agttccagac acctcccaag cacgcagcaa tgcagctcaa aacgcttagc     4800

ctagccacac ccccacggga aacagcagtg attaaccttt agcaataaac gaaagtttaa     4860

ctaagctata ctaaccccag ggttggtcaa tttcgtgcca gccacaccct ggagctagca     4920

aaaaaaa                                                               4927


<210>  142
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope Linker

<400>  142

Gly Pro Gly Pro Gly 
1               5   


<210>  143
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-like Spike-S1-NTD

<400>  143

Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg 
            20                  25                  30          


Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser 
        35                  40                  45              


Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr 
    50                  55                  60                  


Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe 
65                  70                  75                  80  


Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr 
                85                  90                  95      


Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr 
            100                 105                 110         


Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe 
        115                 120                 125             


Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu 
    130                 135                 140                 


Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser 
145                 150                 155                 160 


Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn 
                165                 170                 175     


Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr 
            180                 185                 190         


Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe 
        195                 200                 205             


Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr 
    210                 215                 220                 


Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly 
225                 230                 235                 240 


Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly 
                245                 250                 255     


Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr 
            260                 265                 270         


Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys 
        275                 280                 285             


Cys Thr Leu Lys 
    290         


<210>  144
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SARS-CoV-2 Spike-S1-RBD

<400>  144

Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
1               5                   10                  15      


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
            20                  25                  30          


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
        35                  40                  45              


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
    50                  55                  60                  


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
65                  70                  75                  80  


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
                85                  90                  95      


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
            100                 105                 110         


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
        115                 120                 125             


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
    130                 135                 140                 


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
145                 150                 155                 160 


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
                165                 170                 175     


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
            180                 185                 190         


Val Val Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly 
        195                 200                 205             


Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe 
    210                 215                 220             


<210>  145
<211>  666
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CoV Spike S1-S2_S2

<400>  145

Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys 
1               5                   10                  15      


Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp 
            20                  25                  30          


Ala Val Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn 
        35                  40                  45              


Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr 
    50                  55                  60                  


Gln Thr Gln Thr Asn Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
65                  70                  75                  80  


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn 
                85                  90                  95      


Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu 
            100                 105                 110         


Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val 
        115                 120                 125             


Tyr Ser Thr Gly Ser Asn Val Phe Gln Ser Pro Arg Arg Ala Arg Ser 
    130                 135                 140                 


Val Ala Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu 
145                 150                 155                 160 


Asn Ser Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe 
                165                 170                 175     


Thr Ile Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr 
            180                 185                 190         


Ser Val Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser 
        195                 200                 205             


Asn Leu Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala 
    210                 215                 220                 


Leu Thr Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe 
225                 230                 235                 240 


Ala Gln Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly 
                245                 250                 255     


Gly Phe Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys 
            260                 265                 270         


Arg Ser Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp 
        275                 280                 285             


Ala Gly Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala 
    290                 295                 300                 


Arg Asp Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro 
305                 310                 315                 320 


Pro Leu Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu 
                325                 330                 335     


Ala Gly Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu 
            340                 345                 350         


Gln Ile Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly 
        355                 360                 365             


Val Thr Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln 
    370                 375                 380                 


Phe Asn Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala 
385                 390                 395                 400 


Ser Ala Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala 
                405                 410                 415     


Leu Asn Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser 
            420                 425                 430         


Ser Val Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu 
        435                 440                 445             


Val Gln Ile Asp Arg Leu Ile Thr Gly Arg Leu Gln Ser Leu Gln Thr 
    450                 455                 460                 


Tyr Val Thr Gln Gln Leu Ile Arg Ala Ala Glu Ile Arg Ala Ser Ala 
465                 470                 475                 480 


Asn Leu Ala Ala Thr Lys Met Ser Glu Cys Val Leu Gly Gln Ser Lys 
                485                 490                 495     


Arg Val Asp Phe Cys Gly Lys Gly Tyr His Leu Met Ser Phe Pro Gln 
            500                 505                 510         


Ser Ala Pro His Gly Val Val Phe Leu His Val Thr Tyr Val Pro Ala 
        515                 520                 525             


Gln Glu Lys Asn Phe Thr Thr Ala Pro Ala Ile Cys His Asp Gly Lys 
    530                 535                 540                 


Ala His Phe Pro Arg Glu Gly Val Phe Val Ser Asn Gly Thr His Trp 
545                 550                 555                 560 


Phe Val Thr Gln Arg Asn Phe Tyr Glu Pro Gln Ile Ile Thr Thr Asp 
                565                 570                 575     


Asn Thr Phe Val Ser Gly Asn Cys Asp Val Val Ile Gly Ile Val Asn 
            580                 585                 590         


Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe Lys Glu 
        595                 600                 605             


Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val Asp Leu 
    610                 615                 620                 


Gly Asp Ile Ser Gly Ile Asn Ala Ser Val Val Asn Ile Gln Lys Glu 
625                 630                 635                 640 


Ile Asp Arg Leu Asn Glu Val Ala Lys Asn Leu Asn Glu Ser Leu Ile 
                645                 650                 655     


Asp Leu Gln Glu Leu Gly Lys Tyr Glu Gln 
            660                 665     


<210>  146
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein with a mutation 682-QQAQ-685 mutation

<400>  146

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            580                 585                 590         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        595                 600                 605             


Gln Thr Asn Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    610                 615                 620                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
625                 630                 635                 640 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                645                 650                 655     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            660                 665                 670         


Thr Gly Ser Asn Val Phe Gln Ser Pro Gln Gln Ala Gln Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  147
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein with two proline substitutions (K986P, V987P)

<400>  147

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe 
            580                 585                 590         


Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val 
        595                 600                 605             


Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile 
    610                 615                 620                 


His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser 
625                 630                 635                 640 


Asn Val Phe Gln Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val 
                645                 650                 655     


Asn Asn Ser Tyr Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala 
            660                 665                 670         


Ser Tyr Gln Thr Gln Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Phe Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Ala Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  148
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein with four proline substitutions  (F817P, 
       A892P, A899P, A942P)

<400>  148

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            580                 585                 590         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        595                 600                 605             


Gln Thr Asn Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    610                 615                 620                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
625                 630                 635                 640 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                645                 650                 655     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            660                 665                 670         


Thr Gly Ser Asn Val Phe Gln Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  149
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein with six proline substitutions  (F817P, A892P,
       A899P, A942P, K986P, V987P)

<400>  149

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            580                 585                 590         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        595                 600                 605             


Gln Thr Asn Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    610                 615                 620                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
625                 630                 635                 640 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                645                 650                 655     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            660                 665                 670         


Thr Gly Ser Asn Val Phe Gln Ser Pro Arg Arg Ala Arg Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  150
<211>  1273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  spike glycoprotein with six proline substitutions  (F817P, A892P,
       A899P, A942P, K986P, V987P) and a 682-QQAQ-685 mutation

<400>  150

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile His Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp 
65                  70                  75                  80  


Asn Pro Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu 
                85                  90                  95      


Lys Ser Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser 
            100                 105                 110         


Lys Thr Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile 
        115                 120                 125             


Lys Val Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr 
    130                 135                 140                 


Tyr His Lys Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr 
145                 150                 155                 160 


Ser Ser Ala Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu 
                165                 170                 175     


Met Asp Leu Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe 
            180                 185                 190         


Val Phe Lys Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr 
        195                 200                 205             


Pro Ile Asn Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu 
    210                 215                 220                 


Pro Leu Val Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr 
225                 230                 235                 240 


Leu Leu Ala Leu His Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser 
                245                 250                 255     


Gly Trp Thr Ala Gly Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro 
            260                 265                 270         


Arg Thr Phe Leu Leu Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala 
        275                 280                 285             


Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys 
    290                 295                 300                 


Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val 
305                 310                 315                 320 


Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys 
                325                 330                 335     


Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala 
            340                 345                 350         


Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu 
        355                 360                 365             


Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro 
    370                 375                 380                 


Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe 
385                 390                 395                 400 


Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly 
                405                 410                 415     


Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys 
            420                 425                 430         


Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn 
        435                 440                 445             


Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe 
    450                 455                 460                 


Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys 
465                 470                 475                 480 


Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly 
                485                 490                 495     


Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val 
            500                 505                 510         


Leu Ser Phe Glu Leu Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys 
        515                 520                 525             


Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn 
    530                 535                 540                 


Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu 
545                 550                 555                 560 


Pro Phe Gln Gln Phe Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val 
                565                 570                 575     


Thr Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr 
            580                 585                 590         


Glu Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr 
        595                 600                 605             


Gln Thr Asn Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile Thr Pro 
    610                 615                 620                 


Cys Ser Phe Gly Gly Val Ser Val Ile Thr Pro Gly Thr Asn Thr Ser 
625                 630                 635                 640 


Asn Gln Val Ala Val Leu Tyr Gln Asp Val Asn Cys Thr Glu Val Pro 
                645                 650                 655     


Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr Trp Arg Val Tyr Ser 
            660                 665                 670         


Thr Gly Ser Asn Val Phe Gln Ser Pro Gln Gln Ala Gln Ser Val Ala 
        675                 680                 685             


Ser Gln Ser Ile Ile Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser 
    690                 695                 700                 


Val Ala Tyr Ser Asn Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile 
705                 710                 715                 720 


Ser Val Thr Thr Glu Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val 
                725                 730                 735     


Asp Cys Thr Met Tyr Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu 
            740                 745                 750         


Leu Leu Gln Tyr Gly Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr 
        755                 760                 765             


Gly Ile Ala Val Glu Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln 
    770                 775                 780                 


Val Lys Gln Ile Tyr Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe 
785                 790                 795                 800 


Asn Phe Ser Gln Ile Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser 
                805                 810                 815     


Pro Ile Glu Asp Leu Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly 
            820                 825                 830         


Phe Ile Lys Gln Tyr Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp 
        835                 840                 845             


Leu Ile Cys Ala Gln Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu 
    850                 855                 860                 


Leu Thr Asp Glu Met Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly 
865                 870                 875                 880 


Thr Ile Thr Ser Gly Trp Thr Phe Gly Ala Gly Pro Ala Leu Gln Ile 
                885                 890                 895     


Pro Phe Pro Met Gln Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr 
            900                 905                 910         


Gln Asn Val Leu Tyr Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn 
        915                 920                 925             


Ser Ala Ile Gly Lys Ile Gln Asp Ser Leu Ser Ser Thr Pro Ser Ala 
    930                 935                 940                 


Leu Gly Lys Leu Gln Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn 
945                 950                 955                 960 


Thr Leu Val Lys Gln Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val 
                965                 970                 975     


Leu Asn Asp Ile Leu Ser Arg Leu Asp Pro Pro Glu Ala Glu Val Gln 
            980                 985                 990         


Ile Asp Arg Leu Ile Thr Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val 
        995                 1000                 1005             


Thr Gln  Gln Leu Ile Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn 
    1010                 1015                 1020             


Leu Ala  Ala Thr Lys Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys 
    1025                 1030                 1035             


Arg Val  Asp Phe Cys Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro 
    1040                 1045                 1050             


Gln Ser  Ala Pro His Gly Val  Val Phe Leu His Val  Thr Tyr Val 
    1055                 1060                 1065             


Pro Ala  Gln Glu Lys Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His 
    1070                 1075                 1080             


Asp Gly  Lys Ala His Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn 
    1085                 1090                 1095             


Gly Thr  His Trp Phe Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln 
    1100                 1105                 1110             


Ile Ile  Thr Thr Asp Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val 
    1115                 1120                 1125             


Val Ile  Gly Ile Val Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro 
    1130                 1135                 1140             


Glu Leu  Asp Ser Phe Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn 
    1145                 1150                 1155             


His Thr  Ser Pro Asp Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn 
    1160                 1165                 1170             


Ala Ser  Val Val Asn Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu 
    1175                 1180                 1185             


Val Ala  Lys Asn Leu Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu 
    1190                 1195                 1200             


Gly Lys  Tyr Glu Gln Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu 
    1205                 1210                 1215             


Gly Phe  Ile Ala Gly Leu Ile  Ala Ile Val Met Val  Thr Ile Met 
    1220                 1225                 1230             


Leu Cys  Cys Met Thr Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys 
    1235                 1240                 1245             


Ser Cys  Gly Ser Cys Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro 
    1250                 1255                 1260             


Val Leu  Lys Gly Val Lys Leu  His Tyr Thr 
    1265                 1270             


<210>  151
<211>  1266
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Spike Glycoprotein sequence with 36 mutations and 6 deletions (-)

<400>  151

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Gln Cys Val 
1               5                   10                  15      


Asn Phe Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe 
            20                  25                  30          


Thr Arg Gly Val Tyr Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu 
        35                  40                  45              


His Ser Thr Gln Asp Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp 
    50                  55                  60                  


Phe His Ala Ile Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro 
65                  70                  75                  80  


Val Leu Pro Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser 
                85                  90                  95      


Asn Ile Ile Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr 
            100                 105                 110         


Gln Ser Leu Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val 
        115                 120                 125             


Cys Glu Phe Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr His Lys 
    130                 135                 140                 


Asn Asn Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala 
145                 150                 155                 160 


Asn Asn Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu 
                165                 170                 175     


Glu Gly Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys 
            180                 185                 190         


Asn Ile Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn 
        195                 200                 205             


Leu Val Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val 
    210                 215                 220                 


Asp Leu Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu His Arg 
225                 230                 235                 240 


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
                245                 250                 255     


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
            260                 265                 270         


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
        275                 280                 285             


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
    290                 295                 300                 


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
305                 310                 315                 320 


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Ser Glu Ile Phe 
                325                 330                 335     


Asn Ala Thr Lys Phe Ser Ser Val Tyr Ala Trp Asp Arg Arg Lys Ile 
            340                 345                 350         


Asn Asn Cys Val Ala Asp Tyr Ser Phe Leu Tyr Asn Ser Ala Ser Phe 
        355                 360                 365             


Ser Thr Phe Lys Cys Tyr Gly Val Ser Leu Asn Lys Leu Asn Asp Leu 
    370                 375                 380                 


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Gln 
385                 390                 395                 400 


Val Lys Gln Ile Ala Pro Gly Gln Thr Gly Asn Ile Ala Asp Tyr Asn 
                405                 410                 415     


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
            420                 425                 430         


Lys Lys Leu Asp Ser Lys Val Val Gly Asn His Lys Tyr Arg Phe Arg 
        435                 440                 445             


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
    450                 455                 460                 


Ile Tyr Gln Val Gly Asn Lys Pro Cys Lys Gly Ala Lys Gly Leu Asn 
465                 470                 475                 480 


Cys Tyr Leu Pro Leu Lys Ser Tyr Gly Phe Gln Pro Thr Tyr Gly Val 
                485                 490                 495     


Gly Tyr Gln Pro His Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
            500                 505                 510         


Ala Ser Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
        515                 520                 525             


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
    530                 535                 540                 


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
545                 550                 555                 560 


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
                565                 570                 575     


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
            580                 585                 590         


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
        595                 600                 605             


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
    610                 615                 620                 


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
625                 630                 635                 640 


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
                645                 650                 655     


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
            660                 665                 670         


Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
        675                 680                 685             


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
    690                 695                 700                 


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
705                 710                 715                 720 


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
                725                 730                 735     


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
            740                 745                 750         


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
        755                 760                 765             


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
    770                 775                 780                 


Pro Pro Ile Lys Tyr Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
785                 790                 795                 800 


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
                805                 810                 815     


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
            820                 825                 830         


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
        835                 840                 845             


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
    850                 855                 860                 


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
865                 870                 875                 880 


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
                885                 890                 895     


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
            900                 905                 910         


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
        915                 920                 925             


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
    930                 935                 940                 


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
945                 950                 955                 960 


Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu Ser Arg 
                965                 970                 975     


Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile Thr Gly 
            980                 985                 990         


Arg Leu Gln Ser Leu Gln Thr Tyr  Val Thr Gln Gln Leu  Ile Arg Ala 
        995                 1000                 1005             


Ala Glu  Ile Arg Ala Ser Ala  Asn Leu Ala Ala Thr  Lys Met Ser 
    1010                 1015                 1020             


Glu Cys  Val Leu Gly Gln Ser  Lys Arg Val Asp Phe  Cys Gly Lys 
    1025                 1030                 1035             


Gly Tyr  His Leu Met Ser Phe  Pro Gln Ser Ala Pro  His Gly Val 
    1040                 1045                 1050             


Val Phe  Leu His Val Thr Tyr  Val Pro Ala Gln Glu  Lys Asn Phe 
    1055                 1060                 1065             


Thr Thr  Ala Pro Ala Ile Cys  His Asp Gly Lys Ala  His Phe Pro 
    1070                 1075                 1080             


Arg Glu  Gly Val Phe Val Ser  Asn Gly Thr His Trp  Phe Val Thr 
    1085                 1090                 1095             


Gln Arg  Asn Phe Tyr Glu Pro  Gln Ile Ile Thr Thr  Asp Asn Thr 
    1100                 1105                 1110             


Phe Val  Ser Gly Asn Cys Asp  Val Val Ile Gly Ile  Val Asn Asn 
    1115                 1120                 1125             


Thr Val  Tyr Asp Pro Leu Gln  Pro Glu Leu Asp Ser  Phe Lys Glu 
    1130                 1135                 1140             


Glu Leu  Asp Lys Tyr Phe Lys  Asn His Thr Ser Pro  Asp Val Asp 
    1145                 1150                 1155             


Leu Gly  Asp Ile Ser Gly Ile  Asn Ala Ser Val Val  Asn Ile Gln 
    1160                 1165                 1170             


Lys Glu  Ile Asp Arg Leu Asn  Glu Val Ala Lys Asn  Leu Asn Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asp Leu Gln Glu  Leu Gly Lys Tyr Glu  Gln Tyr Ile 
    1190                 1195                 1200             


Lys Trp  Pro Trp Tyr Ile Trp  Leu Gly Phe Ile Ala  Gly Leu Ile 
    1205                 1210                 1215             


Ala Ile  Val Met Val Thr Ile  Met Leu Cys Cys Met  Thr Ser Cys 
    1220                 1225                 1230             


Cys Ser  Cys Leu Lys Gly Cys  Cys Ser Cys Gly Ser  Cys Cys Lys 
    1235                 1240                 1245             


Phe Asp  Glu Asp Asp Ser Glu  Pro Val Leu Lys Gly  Val Lys Leu 
    1250                 1255                 1260             


His Tyr  Thr 
    1265     


<210>  152
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Wild type native leader sequence

<400>  152

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser 
1               5                   10              


<210>  153
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated CD8+ epitope

<400>  153

Val Leu Asn Asp Ile Leu Ala Arg Leu 
1               5                   


<210>  154
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated CD4+ epitope

<400>  154

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ile 
1               5                   10              


<210>  155
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutated B cell Epitope

<400>  155

Ile Gln Cys Val Asn Leu Thr Thr Arg Thr Gln Leu Pro Pro Ala Tyr 
1               5                   10                  15      


Thr Asn Ser Phe Thr Arg Gly Val Tyr 
            20                  25  


<210>  156
<211>  303
<212>  DNA
<213>  Homo sapiens

<400>  156
atgaacagga aggtgaccgc catcgccctg gccgccatca tctgggccac cgccgcccag       60

ggcttcctga tgttcaagca gggcaggtgc ctgtgcatcg gccccggcat gaaggccgtg      120

aagatggccg agatcgagaa ggccagcgtg atctacccca gcaacggctg cgacaaggtg      180

gaggtgatcg tgaccatgaa ggcccacaag aggcagaggt gcctggaccc caggagcaag      240

caggccaggc tgatcatgca ggccatcgag aagaagaact tcctgaggag gcagaacatg      300

tga                                                                    303


<210>  157
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  157
atgaaggtct ccgcggcagc cctcgctgtc atcctcattg ctactgccct ctgcgctcct       60

gcatctgcct ccccatattc ctcggacacc acaccctgct gctttgccta cattgcccgc      120

ccactgcccc gtgcccacat caaggagtat ttctacacca gtggcaagtg ctccaaccca      180

gcagtcgtcc acaggtcaag gatgccaaag agagagggac agcaagtctg gcaggatttc      240

ctgtatgact cccggctgaa caagggcaag ctttgtcacc cgaaagaacc gccaagtgtg      300

tgccaaccca gagaagaaat gggttcggga gtacatcaac tctttggaga tgagctagga      360

tggagagtcc ttgaacctga acttacacaa atttgcctgt ttctgcttgc tcttgtccta      420

gcttgggagg cttcccctca ctatcctacc ccacccgctc cttga                      465


<210>  158
<211>  378
<212>  DNA
<213>  Homo sapiens

<400>  158
atgaagaaaa gtggtgttct tttcctcttg ggcatcatct tgctggttct gattggagtg       60

caaggaaccc cagtagtgag aaagggtcgc tgttcctgca tcagcaccaa ccaagggact      120

atccacctac aatccttgaa agaccttaaa caatttgccc caagcccttc ctgcgagaaa      180

attgaaatca ttgctacact gaagaatgga gttcaaacat gtctaaaccc agattcagca      240

gatgtgaagg aactgattaa aaagtgggag aaacaggtca gccaaaagaa aaagcaaaag      300

aatgggaaaa aacatcaaaa aaagaaagtt ctgaaagttc gaaaatctca acgttctcgt      360

caaaagaaga ctacataa                                                    378


<210>  159
<211>  297
<212>  DNA
<213>  Homo sapiens

<400>  159
atgaatcaaa ctgccattct gatttgctgc cttatctttc tgactctaag tggcattcaa       60

ggagtacctc tctctagaac tgtacgctgt acctgcatca gcattagtaa tcaacctgtt      120

aatccaaggt ctttagaaaa acttgaaatt attcctgcaa gccaattttg tccacgtgtt      180

gagatcattg ctacaatgaa aaagaagggt gagaagagat gtctgaatcc agaatcgaag      240

gccatcaaga atttactgaa agcagttagc aaggaaaggt ctaaaagatc tccttaa         297


<210>  160
<211>  300
<212>  DNA
<213>  Homo sapiens

<400>  160
atgaggctcc tggcggccgc gctgctcctg ctgctgctgg cgctgtacac cgcgcgtgtg       60

gacgggtcca aatgcaagtg ctcccggaag ggacccaaga tccgctacag cgacgtgaag      120

aagctggaaa tgaagccaaa gtacccgcac tgcgaggaga agatggttat catcaccacc      180

aagagcgtgt ccaggtaccg aggtcaggag cactgcctgc accccaagct gcagagcacc      240

aagcgcttca tcaagtggta caacgcctgg aacgagaagc gcagggtcta cgaagaatag      300


<210>  161
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  161
atgaaagttc taatctcttc cctcctcctg ttgctgccac taatgctgat gtccatggtc       60

tctagcagcc tgaatccagg ggtcgccaga ggccacaggg accgaggcca ggcttctagg      120

agatggctcc aggaaggcgg ccaagaatgt gagtgcaaag attggttcct gagagccccg      180

agaagaaaat tcatgacagt gtctgggctg ccaaagaagc agtgcccctg tgatcatttc      240

aagggcaatg tgaagaaaac aagacaccaa aggcaccaca gaaagccaaa caagcattcc      300

agagcctgcc agcaatttct caaacaatgt cagctaagaa gctttgctct gcctttgtag      360


<210>  162
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  162
atgaacctgt ggctcctggc ctgcctggtg gccggcttcc tgggagcctg ggcccccgct       60

gtccacaccc aaggtgtctt tgaggactgc tgcctggcct accactaccc cattgggtgg      120

gctgtgctcc ggcgcgcctg gacttaccgg atccaggagg tgagcgggag ctgcaatctg      180

cctgctgcga tattctacct ccccaagaga cacaggaagg tgtgtgggaa ccccaaaagc      240

agggaggtgc agagagccat gaagctcctg gatgctcgaa ataaggtttt tgcaaagctc      300

caccacaaca cgcagacctt ccaagcaggc cctcatgctg taaagaagtt gagttctgga      360

aactccaagt tatcatcgtc caagtttagc aatcccatca gcagcagtaa gaggaatgtc      420

tccctcctga tatcagctaa ttcaggactg tga                                   453


<210>  163
<211>  384
<212>  DNA
<213>  Homo sapiens

<400>  163
atgcagcaga gaggactcgc catcgtggcc ttggctgtct gtgcggccct acatgcctca       60

gaagccatac ttcccattgc ctccagctgt tgcacggagg tttcacatca tatttccaga      120

aggctcctgg aaagagtgaa tatgtgtcgc atccagagag ctgatgggga ttgtgacttg      180

gctgctgtca tccttcatgt caagcgcaga agaatctgtg tcagcccgca caaccatact      240

gttaagcagt ggatgaaagt gcaagctgcc aagaaaaatg gtaaaggaaa tgtttgccac      300

aggaagaaac accatggcaa gaggaacagt aacagggcac atcaggggaa acacgaaaca      360

tacggccata aaactcctta ttag                                             384


<210>  164
<211>  465
<212>  DNA
<213>  Homo sapiens

<400>  164
atgttccacg tgagcttcag gtacatcttc ggcatccccc ccctgatcct ggtgctgctg       60

cccgtgacca gcagcgagtg ccacatcaag gacaaggagg gcaaggccta cgagagcgtg      120

ctgatgatca gcatcgacga gctggacaag atgaccggca ccgacagcaa ctgccccaac      180

aacgagccca acttcttcag gaagcacgtg tgcgacgaca ccaaggaggc cgccttcctg      240

aacagggccg ccaggaagct gaagcagttc ctgaagatga acatcagcga ggagttcaac      300

gtgcacctgc tgaccgtgag ccagggcacc cagaccctgg tgaactgcac cagcaaggag      360

gagaagaacg tgaaggagca gaagaagaac gacgcctgct tcctgaagag gctgctgagg      420

gagatcaaga cctgctggaa caagatcctg aagggcagca tctga                      465


<210>  165
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  165
atgagaattt cgaaaccaca tttgagaagt atttccatcc agtgctactt gtgtttactt       60

ctaaacagtc attttctaac tgaagctggc attcatgtct tcattttggg ctgtttcagt      120

gcagggcttc ctaaaacaga agccaactgg gtgaatgtaa taagtgattt gaaaaaaatt      180

gaagatctta ttcaatctat gcatattgat gctactttat atacggaaag tgatgttcac      240

cccagttgca aagtaacagc aatgaagtgc tttctcttgg agttacaagt tatttcactt      300

gagtccggag atgcaagtat tcatgataca gtagaaaatc tgatcatcct agcaaacaac      360

agtttgtctt ctaatgggaa tgtaacagaa tctggatgca aagaatgtga ggaactggag      420

gaaaaaaata ttaaagaatt tttgcagagt tttgtacata ttgtccaaat gttcatcaac      480

acttcttga                                                              489


<210>  166
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  166
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacaaacagt       60

gcacctactt caagttctac aaagaaaaca cagctacaac tggagcattt actgctggat      120

ttacagatga ttttgaatgg aattaataat tacaagaatc ccaaactcac caggatgctc      180

acatttaagt tttacatgcc caagaaggcc acagaactga aacatcttca gtgtctagaa      240

gaagaactca aacctctgga ggaagtgcta aatttagctc aaagcaaaaa ctttcactta      300

agacccaggg acttaatcag caatatcaac gtaatagttc tggaactaaa gggatctgaa      360

acaacattca tgtgtgaata tgctgatgag acagcaacca ttgtagaatt tctgaacaga      420

tggattacct tttgtcaaag catcatctca acactgactt ga                         462


<210>  167
<211>  1733
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG Promoter

<400>  167
ctcgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cgggagtcgc tgcgcgctgc cttcgccccg tgccccgctc cgccgccgcc tcgcgccgcc      720

cgccccggct ctgactgacc gcgttactcc cacaggtgag cgggcgggac ggcccttctc      780

ctccgggctg taattagcgc ttggtttaat gacggcttgt ttcttttctg tggctgcgtg      840

aaagccttga ggggctccgg gagggccctt tgtgcggggg gagcggctcg gggggtgcgt      900

gcgtgtgtgt gtgcgtgggg agcgccgcgt gcggctccgc gctgcccggc ggctgtgagc      960

gctgcgggcg cggcgcgggg ctttgtgcgc tccgcagtgt gcgcgagggg agcgcggccg     1020

ggggcggtgc cccgcggtgc ggggggggct gcgaggggaa caaaggctgc gtgcggggtg     1080

tgtgcgtggg ggggtgagca gggggtgtgg gcgcgtcggt cgggctgcaa ccccccctgc     1140

acccccctcc ccgagttgct gagcacggcc cggcttcggg tgcggggctc cgtacggggc     1200

gtggcgcggg gctcgccgtg ccgggcgggg ggtggcggca ggtgggggtg ccgggcgggg     1260

cggggccgcc tcgggccggg gagggctcgg gggaggggcg cggcggcccc cggagcgccg     1320

gcggctgtcg aggcgcggcg agccgcagcc attgcctttt atggtaatcg tgcgagaggg     1380

cgcagggact tcctttgtcc caaatctgtg cggagccgaa atctgggagg cgccgccgca     1440

ccccctctag cgggcgcggg gcgaagcggt gcggcgccgg caggaaggaa atgggcgggg     1500

agggccttcg tgcgtcgccg cgccgccgtc cccttctccc tctccagcct cggggctgtc     1560

cgcgggggga cggctgcctt cgggggggac ggggcagggc ggggttcggc ttctggcgtg     1620

tgaccggcgg ctctagagcc tctgctaacc atgttcatgc cttcttcttt ttcctacagc     1680

tcctgggcaa cgtgctggtt attgtgctgt ctcatcattt tggcaaagaa ttg            1733


<210>  168
<211>  589
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CMV Promoter

<400>  168
tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata tggagttccg       60

cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc cccgcccatt      120

gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc attgacgtca      180

atgggtggag tatttacggt aaactgccca cttggcagta catcaagtgt atcatatgcc      240

aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt atgcccagta      300

catgacctta tgggactttc ctacttggca gtacatctac gtattagtca tcgctattac      360

catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg actcacgggg      420

atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc aaaatcaacg      480

ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg gtaggcgtgt      540

acggtgggag gtctatataa gcagagctgg tttagtgaac cgtcagatc                  589


<210>  169
<211>  635
<212>  DNA
<213>  Homo sapiens

<400>  169
gtatagggct gtctgggagc cactccaggg ccacagaaat cttgtctctg actcagggta       60

ttttgttttc tgttttgtgt aaatgctctt ctgactaatg caaaccatgt gtccatagaa      120

ccagaagatt tttccagggg aaaaggtaag gaggtggtga gagtgtcctg ggtctgccct      180

tccagggctt gccctgggtt aagagccagg caggaagctc tcaagagcat tgctcaagag      240

tagagggggc ctgggaggcc cagggagggg atgggagggg aacacccagg ctgcccccaa      300

ccagatgccc tccaccctcc tcaacctccc tcccacggcc tggagaggtg ggaccaggta      360

tggaggcttg agagcccctg gttggaggaa gccacaagtc caggaacatg ggagtctggg      420

cagggggcaa aggaggcagg aacaggccat cagccaggac aggtggtaag gcaggcagga      480

gtgttcctgc tgggaaaagg tgggatcaag cacctggagg gctcttcaga gcaaagacaa      540

acactgaggt cgctgccact cctacagagc ccccacgccc cgcccagcta taaggggcca      600

tgcaccaagc agggtaccca ggctgcagag gtgcc                                 635


<210>  170
<211>  1559
<212>  DNA
<213>  Homo sapiens

<400>  170
catccatgcc catggcctca gatgccagcc ataagctgtt gggttccaaa cctcgactcc       60

aggctggact cacccctgtc tcccccacca gcctgacacc tccacctggg tatctaacga      120

gcatctcaaa ctcaacctgc ctgagacaga ggaatcacta tcccctcctc ctccaaaaat      180

atccttccat cacactcccc atcttgtgct ctgatttact aaacggccct gggccctctc      240

tttctcaggg tctctgcttg cccagctata taataaaaca agtttgggac ttcccaacca      300

ttcacccatg gaaaaacaga agcaactctt caaaggacag attcccagga tctgccctgg      360

gagattccaa atcagttgat ctggggtgag cccagtcctc tgtagttttt agaagctcct      420

cctatgtctc tcctggtcag cagaatcttg gcccctccct tccccccagc ctcttggttc      480

ttctgggctc tgatccagcc tcagcgtcac tgtcttccac gcccctcttt gattctcgtt      540

tatgtcaaaa gccttgtgag gatgaggctg tgattatccc cattttacag atgaggaaac      600

tgtggctcca ggatgacaca actggccaga ggtcacatca gaagcagagc tgggtcactt      660

gactccaccc aatatcccta aatgcaaaca tcccctacag accgaggctg gcaccttaga      720

gctggagtcc atgcccgctc tgaccaggag aagccaacct ggtcctccag agccaagagc      780

ttctgtccct ttcccatctc ctgaagcctc cctgtcacct ttaaagtcca ttcccacaaa      840

gacatcatgg gatcaccaca gaaaatcaag ctctggggct aggctgaccc cagctagatt      900

tttggctctt ttatacccca gctgggtgga caagcacctt aaacccgctg agcctcagct      960

tcccgggcta taaaatgggg gtgatgacac ctgcctgtag cattccaagg agggttaaat     1020

gtgatgctgc agccaagggt ccccacagcc aggctctttg caggtgctgg gttcagagtc     1080

ccagagctga ggccgggagt aggggttcaa gtggggtgcc ccaggcaggg tccagtgcca     1140

gccctctgtg gagacagcca tccggggccg aggcagccgc ccaccgcagg gcctgcctat     1200

ctgcagccag cccagccctc acaaaggaac aataacagga aaccatccca gggggaagtg     1260

ggccagggcc agctggaaaa cctgaagggg aggcagccag gcctccctcg ccagcggggt     1320

gtggctcccc tccaaagacg gtcggctgac aggctccaca gagctccact cacgctcagc     1380

cctggacgga caggcagtcc aacggaacag aaacatccct cagcccacag gcacggtgag     1440

tgggggctcc cacactcccc tccaccccaa acccgccacc ctgcgcccaa gatgggaggg     1500

tcctcagctt ccccatctgt agaatgggca tcgtcccact cccatgacag agaggctcc      1559


<210>  171
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  wild type native leader sequence

<400>  171
atgttcgtgt tcctggtgct gctgcccctg gtgagcagc                              39


<210>  172
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  172

Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser Gly Thr Asn 
1               5                   10                  15      


Gly Thr Lys Arg Phe Ala Asn 
            20              


<210>  173
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  173

Asp Ala Val Asp Cys Ala Leu Asp Pro Leu Ser Glu Thr Lys Cys Thr 
1               5                   10                  15      


Leu Lys Ser Phe Thr Val Glu Lys Gly Ile Tyr Gln Thr Ser Asn 
            20                  25                  30      


<210>  174
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  174

Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
1               5                   10                  15      


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
            20                  25                  30          


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Lys Gly Phe Asn 
        35                  40                  45              


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Tyr 
    50                  55                  60          


<210>  175
<211>  62
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  175

Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Arg Tyr Arg Leu 
1               5                   10                  15      


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
            20                  25                  30          


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
        35                  40                  45              


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Glu 
    50                  55                  60          


<210>  176
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  176

Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys Asn Lys Cys Val 
1               5                   10                  15      


Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val Leu Thr Glu Ser 
            20                  25                  30          


Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg Asp Ile Asp Asp 
        35                  40                  45              


Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu Ile Leu Asp Ile 
    50                  55                  60                  


Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
65                  70                  75  


<210>  177
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  177

Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Gly Val Asn 
1               5                   10                  15      


Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro Thr 
            20                  25                  30          


Trp Arg Val Tyr Ser Thr Gly Ser 
        35                  40  


<210>  178
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mutated B cell Epitope

<400>  178

Val Asn Asn Thr Val Tyr Asp Pro Leu Gln Pro Glu Leu Asp Ser Phe 
1               5                   10                  15      


Lys Glu Glu Leu Asp Lys Tyr Phe Lys Asn His Thr Ser Pro Asp Val 
            20                  25                  30          


Asp Leu Gly Asp Ile Ser Gly Ile 
        35                  40  


<210>  179
<211>  12
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  682-QQAQ-685 mutation

<400>  179
cagcaggccc ag                                                           12


<210>  180
<211>  6
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  K986P and V987P mutations

<400>  180
cccccc                                                                   6


<210>  181
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A Linker

<400>  181
ggaagcggag agggcagggg aagtcttcta acatgcgggg acgtggagga aaatcccggc       60

ccc                                                                     63


<210>  182
<211>  69
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E2A Linker

<400>  182
ggaagcggac agtgtactaa ttatgctctc ttgaaattgg ctggagatgt tgagagcaac       60

ccaggtccc                                                               69


<210>  183
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A Linker

<400>  183
ggaagcggag ccacgaactt ctctctgtta aagcaagcag gagatgttga agaaaacccc       60

gggcct                                                                  66


<210>  184
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  6-His Tag

<400>  184
catcaccatc accatcac                                                     18


