                         SEQUENCE LISTING

<110>  ImmunityBio, Inc.
       King, Thomas H.
       Niazi, Kayvan
       Soon-Shiong, Patrick
       Rabizadeh, Shahrooz
 
<120>  YEAST LYSATE COVID-19 VACCINE

<130>  8774-15-PCT

<140>  Not yet assigned
<141>  2021-04-14

<150>  63/010,010
<151>  2020-04-14

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  1251
<212>  DNA
<213>  SARS-CoV-2

<400>  1
gtcagataac gggccacaga accagagaaa cgctcctaga atcactttcg gcgggccttc       60

agattctacg ggctctaatc aaaatggtga aagatcggga gcacgatcaa agcaacgtag      120

acctcaaggc ttgccaaaca acaccgcctc ttggttcaca gctttaacac aacatggtaa      180

ggaagatttg aagttcccaa gaggccaagg tgttcctatt aatacaaata gctcaccaga      240

tgatcaaatt ggttactacc gtagagcgac tagacgtatt aggggcgggg atgggaagat      300

gaaagacttg tctcctagat ggtactttta ctacctgggt acaggaccag aggctggatt      360

accttacggt gcaaacaaag acggcatcat atgggtggct actgaaggtg cgcttaatac      420

accaaaagac catatcggta ccagaaatcc agcgaacaat gcagcaatcg tgttgcaact      480

tcctcaaggt acaactttgc caaagggttt ttacgctgaa ggttcacgtg gtgggagcca      540

agcatcctca agatccagtt caagatctag aaattcatct agaaactcca caccaggttc      600

atctagagga acctccccag ctagaatggc tggaaacggc ggcgatgctg cattagcctt      660

gttgctattg gatagactaa accaattaga gagtaaaatg tctggaaagg gtcagcaaca      720

acagggtcaa acagttacca aaaagtcagc cgcagaggcc tctaaaaagc caagacagaa      780

gagaactgct accaaagcct acaacgttac tcaggccttc ggtagaagag gtcctgagca      840

gacacaaggg aacttcggtg atcaggaatt gatcagacag ggtacagact ataagcattg      900

gccacaaatt gcacaattcg caccgtcagc ttccgctttt ttcggtatga gtcggattgg      960

tatggaagtc actccttctg gaacatggtt aacatatact ggtgccataa agctagatga     1020

caaggaccca aacttcaagg accaagtcat tctgcttaac aagcatatcg atgcatacaa     1080

gacttttcca cctacagaac ctaaaaaaga taaaaaaaaa aaggccgatg aaactcaagc     1140

tctaccacaa agacaaaaaa agcaacaaac agtaacctta ctcccagcag cggacctcga     1200

cgatttctct aagcaactgc aacaatctat gtctagtgca gattccacac a              1251


<210>  2
<211>  418
<212>  PRT
<213>  SARS-CoV-2

<400>  2

Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr Phe 
1               5                   10                  15      


Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg Ser 
            20                  25                  30          


Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr 
        35                  40                  45              


Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Lys 
    50                  55                  60                  


Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp 
65                  70                  75                  80  


Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly 
                85                  90                  95      


Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu 
            100                 105                 110         


Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly 
        115                 120                 125             


Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His 
    130                 135                 140                 


Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu 
145                 150                 155                 160 


Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg 
                165                 170                 175     


Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser 
            180                 185                 190         


Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg 
        195                 200                 205             


Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp 
    210                 215                 220                 


Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln 
225                 230                 235                 240 


Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys 
                245                 250                 255     


Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala 
            260                 265                 270         


Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln 
        275                 280                 285             


Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile Ala 
    290                 295                 300                 


Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile Gly 
305                 310                 315                 320 


Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile 
                325                 330                 335     


Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu Leu 
            340                 345                 350         


Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys 
        355                 360                 365             


Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln Arg 
    370                 375                 380                 


Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp 
385                 390                 395                 400 


Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser Thr 
                405                 410                 415     


Gln Ala 
        


<210>  3
<211>  583
<212>  DNA
<213>  SARS-CoV-2

<400>  3
tggttttcgt gttcaaccaa cagaatccat tgtaagattc ccaaacatca ccaatctatg       60

cccattcggt gaagttttca acgccaccag atttgcttcc gtctacgctt ggaacagaaa      120

gagaatctct aactgtgtcg ctgattactc tgttttgtac aactctgctt ctttctctac      180

tttcaagtgt tacggtgttt ctccaaccaa attgaacgac ttgtgtttca ctaacgttta      240

cgccgattcc tttgtcatca gaggtgacga agtcagacaa atcgctccag gtcaaactgg      300

taagattgcc gattacaact acaagttgcc agacgatttc accggttgtg ttattgcttg      360

gaactccaac aacttggact ccaaggttgg tggtaactat aattatttat acagattatt      420

cagaaagagt aacttgaagc cattcgaaag agacatttcc actgaaatct accaagctgg      480

ttctactcca tgtaacggtg ttgaaggttt caactgttac ttcccattgc aatcttacgg      540

cttccaacct accaacggtg tcggttacca accataccgt gtc                        583


<210>  4
<211>  193
<212>  PRT
<213>  SARS-CoV-2

<400>  4

Phe Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr 
1               5                   10                  15      


Asn Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser 
            20                  25                  30          


Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr 
        35                  40                  45              


Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly 
    50                  55                  60                  


Val Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala 
65                  70                  75                  80  


Asp Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly 
                85                  90                  95      


Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe 
            100                 105                 110         


Thr Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val 
        115                 120                 125             


Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu 
    130                 135                 140                 


Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser 
145                 150                 155                 160 


Thr Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln 
                165                 170                 175     


Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg 
            180                 185                 190         


Val 
    


<210>  5
<211>  2078
<212>  DNA
<213>  SARS-CoV-2

<400>  5
gaattcgcca ccatgggatc ctacccttac gatgtccctg attatgccgg ccctggtcct       60

ggtcaattac ctcctgcata cacaaattca ttcactagag gcgtttacta ccccgacaag      120

gtctttagat catcagtctt acattccacg caagatctat tcttgccttt cttctctaac      180

gttacctggt tccatgcgat ccatgtatct ggtacaaatg gtaccaagcg tttcgacaat      240

ccagtgttgc cattcaacga tggtgtgtac tttgcttcca ctgaaaaatc aaacattatc      300

agaggctgga tatttggaac aacattagat agcaagacac aatcactatt gatcgttaac      360

aacgctacaa acgtcgttat caaggtctgt gagttccaat tttgcaacga tccattcctt      420

ggtgtctact accacaaaaa caataagtct tggatggaat cagaatttcg tgtttactct      480

tcagcaaaca actgcacctt cgaatatgtt tctcagccat ttttgatgga tctggaaggc      540

aagcaaggga acttcaaaaa tttacgagag ttcgttttca aaaatattga tggttacttc      600

aagatatact ctaagcatac accaattaac ttggtcagag atttgcctca aggtttctct      660

gcactagaac cacttgttga tttgccaatt ggtattaaca ttactagatt tcagacatta      720

ctagcattgc acagatcata cctaacacct ggtgattcat cttctgggtg gaccgctgga      780

gcagccgcct actacgtggg ttatttgcag cctagaacat tcctgctcaa gtataacgaa      840

aacgggacaa tcactgatgc agttgactgt gcacttgacc cattgagtga aaccaagtgt      900

acactaaagt cgttcactgt tgaaaaggga atttaccaaa catcaaactt cagagtgcag      960

ccaaccgagt cgatcgttag attcccaaac attactaatt tgtgtccttt cggtgaagta     1020

ttcaatgcaa ctagatttgc atcagtctat gcctggaaca ggaaacgtat ctctaactgt     1080

gttgctgatt acagcgtctt atacaattca gcctcattca gcacatttaa gtgctacggt     1140

gtatctccta caaagttgaa tgatctctgc tttacaaacg tatacgctga ctccttcgtt     1200

atcagaggtg atgaagtcag acaaatcgca cctggtcaaa ccgggaagat agctgattac     1260

aactacaaat taccagacga ttttaccggt tgcgttatag catggaactc aaataacttg     1320

gattccaagg tcggtggaaa ttacaattac ttgtacagac tgttcagaaa atctaacctg     1380

aagccattcg agcgggatat ttcaacagaa atttatcagg ccggctctac tccatgtaat     1440

ggtgtggaag ggttcaactg ttactttcca ttgcaatcat atggctttca gccaacaaat     1500

ggtgtcggat accaacctta cagagttgtt gttttgtctt ttgaactact gcatgcccca     1560

gcaacagttt gcggccctaa aaagtccaca aatcttgtta aaaataagtg cgtgaatttt     1620

aactttaacg gtttgaccgg aacaggcgtg ttgactgaat caaacaaaaa gttcttgcca     1680

ttccaacagt ttggtagaga cattgctgac actacagatg ccgttcggga ccctcaaact     1740

ttagaaatcc tggatataac tccttgctct ttcggcggag tatctgtgat aactccaggg     1800

actaacacgt ctaaccaagt tgccgtcctt taccaagatg tgaactgcac cgaagttcca     1860

gttgctattc atgcagatca actcacacca acttggagag tatattcaac tggatcaaac     1920

gttttccaaa ctagagctgg atgtctaatc ggagcagaac acgttaacaa ctcttacgaa     1980

tgtgatatcc cgattggcgc tggaatatgt gcctcttacc aaacacagac aaacagtcac     2040

catcaccatc atcatcacca ccatcattaa gcggccgc                             2078


<210>  6
<211>  658
<212>  PRT
<213>  SARS-CoV-2

<400>  6

Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr 
1               5                   10                  15      


Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu 
            20                  25                  30          


Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val 
        35                  40                  45              


Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe 
    50                  55                  60                  


Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg 
65                  70                  75                  80  


Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu 
                85                  90                  95      


Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln 
            100                 105                 110         


Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys 
        115                 120                 125             


Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys 
    130                 135                 140                 


Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys 
145                 150                 155                 160 


Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp 
                165                 170                 175     


Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg 
            180                 185                 190         


Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro 
        195                 200                 205             


Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg 
    210                 215                 220                 


Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala 
225                 230                 235                 240 


Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys 
                245                 250                 255     


Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp 
            260                 265                 270         


Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys 
        275                 280                 285             


Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile 
    290                 295                 300                 


Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe 
305                 310                 315                 320 


Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile 
                325                 330                 335     


Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe 
            340                 345                 350         


Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu 
        355                 360                 365             


Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu 
    370                 375                 380                 


Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn 
385                 390                 395                 400 


Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser 
                405                 410                 415     


Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg 
            420                 425                 430         


Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr 
        435                 440                 445             


Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe 
    450                 455                 460                 


Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly 
465                 470                 475                 480 


Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu 
                485                 490                 495     


His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val 
            500                 505                 510         


Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly 
        515                 520                 525             


Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly 
    530                 535                 540                 


Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu 
545                 550                 555                 560 


Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile 
                565                 570                 575     


Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp 
            580                 585                 590         


Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr 
        595                 600                 605             


Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg 
    610                 615                 620                 


Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys 
625                 630                 635                 640 


Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr 
                645                 650                 655     


Asn Ser 
        


<210>  7
<211>  3911
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7
actagtatgt tcgtttttct cgttctcctc ccgcttgtga gcagctatcc gtatgatgtg       60

ccggattatg cgggtggagg ctctggaggt ggctctggtg gaggttccgg tggcggatct      120

caatgtgtca acctcaccac aaggacacag ctccctcccg catatacgaa tagctttacc      180

agaggcgtat actatcctga taaggtcttt aggagctcag tactgcatag cactcaggat      240

ctcttcctgc cgttcttcag taatgttact tggtttcacg ccattcatgt ttccgggacc      300

aatggcacca aacggttcga taatccagtg cttcccttca acgatggggt gtactttgcc      360

agcactgaaa aatctaatat aattcgggga tggattttcg gaaccacact cgattccaag      420

actcagtccc tcttgatcgt taacaacgct actaatgttg tcattaaggt gtgtgagttt      480

cagttctgca acgacccttt cctgggtgtc tactaccata aaaataacaa gagctggatg      540

gagtccgaat ttcgcgtcta ctcaagcgcc aataattgca cttttgagta tgtgtcccag      600

ccctttttga tggatctgga gggaaagcag ggcaatttca aaaatctgag agaattcgtt      660

tttaagaata tagatggata cttcaaaatc tacagcaaac acacacccat aaatcttgtg      720

cgcgatcttc cccagggctt cagcgcgttg gaaccccttg ttgacttgcc cataggcatc      780

aacattacca ggttccaaac gctgctcgcc ctccaccgca gctacttgac acccggggat      840

tccagctccg gatggaccgc cggcgccgca gcgtattatg tggggtacct gcaacccagg      900

acatttttgc tcaagtacaa tgagaatggg accatcacag atgcggtaga ctgtgcactg      960

gatccactca gcgaaactaa atgtaccctg aaaagcttta ccgtggagaa aggaatctac     1020

caaaccagca acttcagggt ccagcccact gaatccatcg ttagatttcc aaatataact     1080

aatttgtgtc catttggaga ggtgttcaat gctacaaggt tcgcgtctgt atacgcttgg     1140

aaccggaagc gcatctcaaa ttgcgtggct gattatagcg ttctttacaa cagcgcttcc     1200

ttttccacgt tcaagtgcta tggtgtatcc ccgacaaagc tgaatgactt gtgcttcacc     1260

aatgtgtatg cggattcttt cgttattcga ggcgatgaag tcagacaaat tgcgcctggc     1320

cagaccggaa agattgccga ctacaactat aaactgccgg acgactttac tggttgcgtg     1380

atcgcttgga acagcaataa tcttgatagt aaagttggag gaaactacaa ttacctctat     1440

agactgttca gaaagagcaa cttgaagcca ttcgaacggg atatctctac ggagatctat     1500

caagctggca gcaccccctg caatggtgtg gaaggcttta attgttattt tcctttgcag     1560

agctatggct tccaacctac caacggagtg ggctaccagc cctacagagt ggtggtgctc     1620

agctttgaac tgctgcatgc cccggccaca gtttgcgggc ccaaaaaaag cacgaatctg     1680

gttaagaaca aatgcgtcaa cttcaatttt aatgggttga caggtacagg cgtactgacc     1740

gaatccaaca aaaagttcct gccttttcag cagttcggga gagatatcgc cgacactaca     1800

gacgccgtca gggatcccca aacactcgaa attctggaca tcacaccttg ttccttcggc     1860

ggggtatctg tgattactcc gggcacaaat accagtaacc aggtagcggt gctttaccag     1920

gatgtcaact gtacggaagt acctgtcgct attcatgcgg atcaactcac tcctacctgg     1980

agagtttatt ccactgggtc caacgtgttt cagacccgag ccggctgctt gattggcgcg     2040

gaacatgtta acaactccta cgaatgtgac atccctatcg gagctggcat ctgtgcttcc     2100

tatcaaacgc aaacgaacag cccaggttct gctagttccg tagcctctca aagcatcatc     2160

gcttatacta tgtccttggg ggctgaaaac agcgttgcct attccaacaa tagcatcgct     2220

atccctacca actttaccat ttccgtgacc acagaaatac tgccggtgag catgacaaag     2280

acttctgtgg actgtaccat gtatatatgc ggcgatagca cagagtgttc taatttgctg     2340

ctgcagtacg gcagcttttg tacccaactc aacagagcac ttacagggat tgccgtcgag     2400

caggataaaa acacccagga ggttttcgcc caggttaagc agatctacaa gaccccacca     2460

atcaaggatt tcggcggctt caatttttcc cagatactgc ccgatccttc caagccatcc     2520

aaaaggagct ttatagagga tctgctgttc aacaaggtga ctctggccga cgctggcttt     2580

atcaagcaat atggcgattg cctgggggat attgccgcta gggaccttat ctgcgctcaa     2640

aaattcaacg gtcttaccgt tctcccgccc ctgctcaccg acgagatgat agcccagtac     2700

acgagcgcac ttttggccgg cacgataacc agcggctgga cattcggtgc cggggccgct     2760

cttcaaatcc cctttgccat gcagatggcc tacagattta atgggatagg cgtgacacaa     2820

aatgtcttgt atgaaaatca gaaactgatt gcaaaccagt ttaatagcgc tattggcaag     2880

atccaagata gcctttcctc caccgcatcc gctctgggaa agttgcaaga cgtcgtgaat     2940

caaaacgccc aagctctgaa taccctcgtg aagcagctta gctccaactt tggcgcgata     3000

tcctccgtgc tgaacgatat cctgtccaga ttggaccctc ctgaggcaga agtccagatc     3060

gatagattga taaccggcag actccagtct ctgcagacat atgtgactca gcagttgata     3120

agagcggccg aaatacgagc gtctgcaaat ctcgcagcaa cgaaaatgtc agagtgtgta     3180

ttggggcaaa gtaaaagagt agatttctgt ggaaagggtt accatctgat gtcattcccc     3240

cagtctgcac cacatggagt agtttttttg catgtgactt atgtgcctgc ccaggagaaa     3300

aatttcacca ctgcacctgc gatctgtcat gacggcaagg cacatttccc tagagaaggc     3360

gtcttcgtat caaatggaac acactggttt gtaacccaaa ggaactttta cgagccccaa     3420

attataacta ccgacaacac cttcgtaagc ggaaactgcg acgtcgttat agggatagtc     3480

aataatacgg tctatgaccc tcttcagccg gaactggact cctttaaaga agaactggat     3540

aagtacttca agaaccatac gtctccggat gtggatctcg gagatataag tggaatcaac     3600

gcaagcgtag taaacattca gaaggagata gaccgactca atgaggttgc taaaaacctg     3660

aacgaaagct tgatagactt gcaggagctg ggtaagtacg aacagtacat taagtggcca     3720

tggtatatct ggttgggctt catagcagga ctcatagcta tcgtcatggt gacaataatg     3780

ctttgttgta tgaccagctg ttgttcttgt ctgaaaggct gctgcagctg tggcagctgt     3840

tgtaaatttg acgaagatga ttccgagcct gtgcttaagg gcgtaaaact ccactataca     3900

tgagcggccg c                                                          3911


<210>  8
<211>  1298
<212>  PRT
<213>  SARS-CoV-2

<400>  8

Met Phe Val Phe Leu Val Leu Leu Pro Leu Val Ser Ser Tyr Pro Tyr 
1               5                   10                  15      


Asp Val Pro Asp Tyr Ala Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Ser Gln Cys Val Asn Leu Thr Thr Arg Thr Gln 
        35                  40                  45              


Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr Tyr Pro 
    50                  55                  60                  


Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp Leu Phe 
65                  70                  75                  80  


Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His Val Ser 
                85                  90                  95      


Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro Phe Asn 
            100                 105                 110         


Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile Arg Gly 
        115                 120                 125             


Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu Leu Ile 
    130                 135                 140                 


Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe Gln Phe 
145                 150                 155                 160 


Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn Lys Ser 
                165                 170                 175     


Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn Cys Thr 
            180                 185                 190         


Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly Lys Gln 
        195                 200                 205             


Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile Asp Gly 
    210                 215                 220                 


Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val Arg Asp 
225                 230                 235                 240 


Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu Pro Ile 
                245                 250                 255     


Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His Arg Ser 
            260                 265                 270         


Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly Ala Ala 
        275                 280                 285             


Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu Lys Tyr 
    290                 295                 300                 


Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu Asp Pro 
305                 310                 315                 320 


Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu Lys Gly 
                325                 330                 335     


Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser Ile Val 
            340                 345                 350         


Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val Phe Asn 
        355                 360                 365             


Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg Ile Ser 
    370                 375                 380                 


Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser Phe Ser 
385                 390                 395                 400 


Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp Leu Cys 
                405                 410                 415     


Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp Glu Val 
            420                 425                 430         


Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr Asn Tyr 
        435                 440                 445             


Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn Ser Asn 
    450                 455                 460                 


Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu 
465                 470                 475                 480 


Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser Thr Glu 
                485                 490                 495     


Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly Phe Asn 
            500                 505                 510         


Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn Gly Val 
        515                 520                 525             


Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu Leu His 
    530                 535                 540                 


Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu Val Lys 
545                 550                 555                 560 


Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr Gly Val 
                565                 570                 575     


Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe Gly Arg 
            580                 585                 590         


Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr Leu Glu 
        595                 600                 605             


Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val Ile Thr 
    610                 615                 620                 


Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln Asp Val 
625                 630                 635                 640 


Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu Thr Pro 
                645                 650                 655     


Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr Arg Ala 
            660                 665                 670         


Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu Cys Asp 
        675                 680                 685             


Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln Thr Asn 
    690                 695                 700                 


Ser Pro Gly Ser Ala Ser Ser Val Ala Ser Gln Ser Ile Ile Ala Tyr 
705                 710                 715                 720 


Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn Asn Ser 
                725                 730                 735     


Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu Ile Leu 
            740                 745                 750         


Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr Ile Cys 
        755                 760                 765             


Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly Ser Phe 
    770                 775                 780                 


Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu Gln Asp 
785                 790                 795                 800 


Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr Lys Thr 
                805                 810                 815     


Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile Leu Pro 
            820                 825                 830         


Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu Leu Phe 
        835                 840                 845             


Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr Gly Asp 
    850                 855                 860                 


Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln Lys Phe 
865                 870                 875                 880 


Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met Ile Ala 
                885                 890                 895     


Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly Trp Thr 
            900                 905                 910         


Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln Met Ala 
        915                 920                 925             


Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr Glu Asn 
    930                 935                 940                 


Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys Ile Gln 
945                 950                 955                 960 


Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln Asp Val 
                965                 970                 975     


Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln Leu Ser 
            980                 985                 990         


Ser Asn Phe Gly Ala Ile Ser Ser  Val Leu Asn Asp Ile  Leu Ser Arg 
        995                 1000                 1005             


Leu Asp  Pro Pro Glu Ala Glu  Val Gln Ile Asp Arg  Leu Ile Thr 
    1010                 1015                 1020             


Gly Arg  Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
    1025                 1030                 1035             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1040                 1045                 1050             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1055                 1060                 1065             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1070                 1075                 1080             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1085                 1090                 1095             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1100                 1105                 1110             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1115                 1120                 1125             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1130                 1135                 1140             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1145                 1150                 1155             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1160                 1165                 1170             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1175                 1180                 1185             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1190                 1195                 1200             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1205                 1210                 1215             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1220                 1225                 1230             


Tyr Ile  Lys Trp Pro Trp Tyr  Ile Trp Leu Gly Phe  Ile Ala Gly 
    1235                 1240                 1245             


Leu Ile  Ala Ile Val Met Val  Thr Ile Met Leu Cys  Cys Met Thr 
    1250                 1255                 1260             


Ser Cys  Cys Ser Cys Leu Lys  Gly Cys Cys Ser Cys  Gly Ser Cys 
    1265                 1270                 1275             


Cys Lys  Phe Asp Glu Asp Asp  Ser Glu Pro Val Leu  Lys Gly Val 
    1280                 1285                 1290             


Lys Leu  His Tyr Thr 
    1295             


<210>  9
<211>  1960
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9
gatcattcac gaattcgcca ccatgctcga gaagcctatc cctaaccctc tcctcggtct       60

cgattctacg tcagataacg ggccacagaa ccagagaaac gctcctagaa tcactttcgg      120

cgggccttca gattctacgg gctctaatca aaatggtgaa agatcgggag cacgatcaaa      180

gcaacgtaga cctcaaggct tgccaaacaa caccgcctct tggttcacag ctttaacaca      240

acatggtaag gaagatttga agttcccaag aggccaaggt gttcctatta atacaaatag      300

ctcaccagat gatcaaattg gttactaccg tagagcgact agacgtatta ggggcgggga      360

tgggaagatg aaagacttgt ctcctagatg gtacttttac tacctgggta caggaccaga      420

ggctggatta ccttacggtg caaacaaaga cggcatcata tgggtggcta ctgaaggtgc      480

gcttaataca ccaaaagacc atatcggtac cagaaatcca gcgaacaatg cagcaatcgt      540

gttgcaactt cctcaaggta caactttgcc aaagggtttt tacgctgaag gttcacgtgg      600

tgggagccaa gcatcctcaa gatccagttc aagatctaga aattcatcta gaaactccac      660

accaggttca tctagaggaa cctccccagc tagaatggct ggaaacggcg gcgatgctgc      720

attagccttg ttgctattgg atagactaaa ccaattagag agtaaaatgt ctggaaaggg      780

tcagcaacaa cagggtcaaa cagttaccaa aaagtcagcc gcagaggcct ctaaaaagcc      840

aagacagaag agaactgcta ccaaagccta caacgttact caggccttcg gtagaagagg      900

tcctgagcag acacaaggga acttcggtga tcaggaattg atcagacagg gtacagacta      960

taagcattgg ccacaaattg cacaattcgc accgtcagct tccgcttttt tcggtatgag     1020

tcggattggt atggaagtca ctccttctgg aacatggtta acatatactg gtgccataaa     1080

gctagatgac aaggacccaa acttcaagga ccaagtcatt ctgcttaaca agcatatcga     1140

tgcatacaag acttttccac ctacagaacc taaaaaagat aaaaaaaaaa aggccgatga     1200

aactcaagct ctaccacaaa gacaaaaaaa gcaacaaaca gtaaccttac tcccagcagc     1260

ggacctcgac gatttctcta agcaactgca acaatctatg tctagtgcag attccacaca     1320

ggctggttcc ggttctggtt ctggttccgg tggttctggt tttcgtgttc aaccaacaga     1380

atccattgta agattcccaa acatcaccaa tctatgccca ttcggtgaag ttttcaacgc     1440

caccagattt gcttccgtct acgcttggaa cagaaagaga atctctaact gtgtcgctga     1500

ttactctgtt ttgtacaact ctgcttcttt ctctactttc aagtgttacg gtgtttctcc     1560

aaccaaattg aacgacttgt gtttcactaa cgtttacgcc gattcctttg tcatcagagg     1620

tgacgaagtc agacaaatcg ctccaggtca aactggtaag attgccgatt acaactacaa     1680

gttgccagac gatttcaccg gttgtgttat tgcttggaac tccaacaact tggactccaa     1740

ggttggtggt aactataatt atttatacag attattcaga aagagtaact tgaagccatt     1800

cgaaagagac atttccactg aaatctacca agctggttct actccatgta acggtgttga     1860

aggtttcaac tgttacttcc cattgcaatc ttacggcttc caacctacca acggtgtcgg     1920

ttaccaacca taccgtgtct aagcggccgc aataggaaaa                           1960


<210>  10
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Met Leu Glu Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  15      


Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr Phe 
            20                  25                  30          


Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg Ser 
        35                  40                  45              


Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn Thr 
    50                  55                  60                  


Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu Lys 
65                  70                  75                  80  


Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro Asp 
                85                  90                  95      


Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly Gly 
            100                 105                 110         


Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr Leu 
        115                 120                 125             


Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp Gly 
    130                 135                 140                 


Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp His 
145                 150                 155                 160 


Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln Leu 
                165                 170                 175     


Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser Arg 
            180                 185                 190         


Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn Ser 
        195                 200                 205             


Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala Arg 
    210                 215                 220                 


Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu Asp 
225                 230                 235                 240 


Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln Gln 
                245                 250                 255     


Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys Lys 
            260                 265                 270         


Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln Ala 
        275                 280                 285             


Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp Gln 
    290                 295                 300                 


Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile Ala 
305                 310                 315                 320 


Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile Gly 
                325                 330                 335     


Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala Ile 
            340                 345                 350         


Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu Leu 
        355                 360                 365             


Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro Lys 
    370                 375                 380                 


Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln Arg 
385                 390                 395                 400 


Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu Asp 
                405                 410                 415     


Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser Thr 
            420                 425                 430         


Gln Ala Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Phe Arg 
        435                 440                 445             


Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn Leu 
    450                 455                 460                 


Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr 
465                 470                 475                 480 


Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser Val 
                485                 490                 495     


Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser 
            500                 505                 510         


Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser 
        515                 520                 525             


Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln Thr 
    530                 535                 540                 


Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly 
545                 550                 555                 560 


Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly Gly 
                565                 570                 575     


Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro 
            580                 585                 590         


Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro 
        595                 600                 605             


Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr 
    610                 615                 620                 


Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
625                 630                 635                 


<210>  11
<211>  3684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11
gaattcgcca ccatgggatc ctacccttac gatgtccctg attatgccgg ccctggtcct       60

ggtcaattac ctcctgcata cacaaattca ttcactagag gcgtttacta ccccgacaag      120

gtctttagat catcagtctt acattccacg caagatctat tcttgccttt cttctctaac      180

gttacctggt tccatgcgat ccatgtatct ggtacaaatg gtaccaagcg tttcgacaat      240

ccagtgttgc cattcaacga tggtgtgtac tttgcttcca ctgaaaaatc aaacattatc      300

agaggctgga tatttggaac aacattagat agcaagacac aatcactatt gatcgttaac      360

aacgctacaa acgtcgttat caaggtctgt gagttccaat tttgcaacga tccattcctt      420

ggtgtctact accacaaaaa caataagtct tggatggaat cagaatttcg tgtttactct      480

tcagcaaaca actgcacctt cgaatatgtt tctcagccat ttttgatgga tctggaaggc      540

aagcaaggga acttcaaaaa tttacgagag ttcgttttca aaaatattga tggttacttc      600

aagatatact ctaagcatac accaattaac ttggtcagag atttgcctca aggtttctct      660

gcactagaac cacttgttga tttgccaatt ggtattaaca ttactagatt tcagacatta      720

ctagcattgc acagatcata cctaacacct ggtgattcat cttctgggtg gaccgctgga      780

gcagccgcct actacgtggg ttatttgcag cctagaacat tcctgctcaa gtataacgaa      840

aacgggacaa tcactgatgc agttgactgt gcacttgacc cattgagtga aaccaagtgt      900

acactaaagt cgttcactgt tgaaaaggga atttaccaaa catcaaactt cagagtgcag      960

ccaaccgagt cgatcgttag attcccaaac attactaatt tgtgtccttt cggtgaagta     1020

ttcaatgcaa ctagatttgc atcagtctat gcctggaaca ggaaacgtat ctctaactgt     1080

gttgctgatt acagcgtctt atacaattca gcctcattca gcacatttaa gtgctacggt     1140

gtatctccta caaagttgaa tgatctctgc tttacaaacg tatacgctga ctccttcgtt     1200

atcagaggtg atgaagtcag acaaatcgca cctggtcaaa ccgggaagat agctgattac     1260

aactacaaat taccagacga ttttaccggt tgcgttatag catggaactc aaataacttg     1320

gattccaagg tcggtggaaa ttacaattac ttgtacagac tgttcagaaa atctaacctg     1380

aagccattcg agcgggatat ttcaacagaa atttatcagg ccggctctac tccatgtaat     1440

ggtgtggaag ggttcaactg ttactttcca ttgcaatcat atggctttca gccaacaaat     1500

ggtgtcggat accaacctta cagagttgtt gttttgtctt ttgaactact gcatgcccca     1560

gcaacagttt gcggccctaa aaagtccaca aatcttgtta aaaataagtg cgtgaatttt     1620

aactttaacg gtttgaccgg aacaggcgtg ttgactgaat caaacaaaaa gttcttgcca     1680

ttccaacagt ttggtagaga cattgctgac actacagatg ccgttcggga ccctcaaact     1740

ttagaaatcc tggatataac tccttgctct ttcggcggag tatctgtgat aactccaggg     1800

actaacacgt ctaaccaagt tgccgtcctt taccaagatg tgaactgcac cgaagttcca     1860

gttgctattc atgcagatca actcacacca acttggagag tatattcaac tggatcaaac     1920

gttttccaaa ctagagctgg atgtctaatc ggagcagaac acgttaacaa ctcttacgaa     1980

tgtgatatcc cgattggcgc tggaatatgt gcctcttacc aaacacagac aaacagtcca     2040

agacgtgcta gatccgttgc ctcacagtct atcattgcat acaccatgtc tttaggtgca     2100

gaaaattcag tggcttacag caacaattcc atcgcgatac ctaccaactt cacgatcagt     2160

gtgactacgg aaatccttcc agtctcaatg acaaaaacat ctgttgattg cacaatgtac     2220

atatgtggtg actcaactga gtgttctaac cttctactac aatacggatc attctgtacc     2280

caattgaata gagcgcttac tggtattgcg gtcgagcaag ataaaaacac acaagaggtt     2340

tttgcacaag ttaagcaaat ttacaaaaca ccacctataa aagactttgg cggctttaac     2400

ttcagtcaaa tcctaccaga tcctagtaag ccaagcaaga gatcatttat cgaagattta     2460

cttttcaata aggtaacttt ggctgacgct ggtttcatta agcaatacgg tgattgcttg     2520

ggggacattg cagctcgtga tctgatctgt gcccagaagt tcaacggctt aacagtatta     2580

ccaccattac ttacagatga aatgatcgct caatacacat ctgctttatt ggctggtact     2640

ataacatccg gctggacctt tggtgctgga gccgccttgc aaatcccatt cgcaatgcag     2700

atggcttaca gattcaacgg tattggcgtc acacaaaacg tcttgtacga gaaccaaaag     2760

ttaattgcta atcagttcaa tagtgctatt ggtaagatcc aagatagttt atcttctact     2820

gcatcggcct tgggtaagct ccaagatgtc gtgaaccaaa acgctcaagc actcaacacc     2880

cttgttaagc aactatcatc taatttcggt gcaatttcct ctgtcctgaa tgacatttta     2940

tctcgattgg acaaagttga ggccgaggtt caaattgata gacttattac tggcagactt     3000

caatctctac agacatacgt tacacaacag ttaatcagag ctgctgaaat tagagcttct     3060

gcgaacttag ctgcgactaa aatgtctgag tgtgttttag gacagtctaa gagagttgac     3120

ttctgcggga agggatacca tctaatgtca ttcccacaaa gtgcacctca cggtgtcgtg     3180

tttcttcatg ttacatacgt cccagcgcag gaaaaaaact ttacaaccgc accagctatt     3240

tgtcacgatg gaaaggcaca tttcccaaga gagggtgtgt ttgtatccaa cggtacccac     3300

tggttcgtta ctcagagaaa tttctatgaa ccacaaatca ttacaacaga taacacattc     3360

gtttccggca attgtgatgt agttattggt attgtaaata atactgtata cgatccattg     3420

caaccagagt tagactcatt caaagaggaa ctcgataagt acttcaaaaa ccatacttcc     3480

ccagatgtag atttagggga catctctggt attaacgcat ccgtggttaa catccaaaag     3540

gaaatcgaca gacttaacga agttgcgaaa aacttaaacg aatctttgat cgacctccaa     3600

gagttgggaa aatacgaaca atacataaaa tggccatggt atattcacca tcaccatcat     3660

catcaccacc atcattaaac tagt                                            3684


<210>  12
<211>  1221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Met Gly Ser Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Pro Gly Pro 
1               5                   10                  15      


Gly Gln Leu Pro Pro Ala Tyr Thr Asn Ser Phe Thr Arg Gly Val Tyr 
            20                  25                  30          


Tyr Pro Asp Lys Val Phe Arg Ser Ser Val Leu His Ser Thr Gln Asp 
        35                  40                  45              


Leu Phe Leu Pro Phe Phe Ser Asn Val Thr Trp Phe His Ala Ile His 
    50                  55                  60                  


Val Ser Gly Thr Asn Gly Thr Lys Arg Phe Asp Asn Pro Val Leu Pro 
65                  70                  75                  80  


Phe Asn Asp Gly Val Tyr Phe Ala Ser Thr Glu Lys Ser Asn Ile Ile 
                85                  90                  95      


Arg Gly Trp Ile Phe Gly Thr Thr Leu Asp Ser Lys Thr Gln Ser Leu 
            100                 105                 110         


Leu Ile Val Asn Asn Ala Thr Asn Val Val Ile Lys Val Cys Glu Phe 
        115                 120                 125             


Gln Phe Cys Asn Asp Pro Phe Leu Gly Val Tyr Tyr His Lys Asn Asn 
    130                 135                 140                 


Lys Ser Trp Met Glu Ser Glu Phe Arg Val Tyr Ser Ser Ala Asn Asn 
145                 150                 155                 160 


Cys Thr Phe Glu Tyr Val Ser Gln Pro Phe Leu Met Asp Leu Glu Gly 
                165                 170                 175     


Lys Gln Gly Asn Phe Lys Asn Leu Arg Glu Phe Val Phe Lys Asn Ile 
            180                 185                 190         


Asp Gly Tyr Phe Lys Ile Tyr Ser Lys His Thr Pro Ile Asn Leu Val 
        195                 200                 205             


Arg Asp Leu Pro Gln Gly Phe Ser Ala Leu Glu Pro Leu Val Asp Leu 
    210                 215                 220                 


Pro Ile Gly Ile Asn Ile Thr Arg Phe Gln Thr Leu Leu Ala Leu His 
225                 230                 235                 240 


Arg Ser Tyr Leu Thr Pro Gly Asp Ser Ser Ser Gly Trp Thr Ala Gly 
                245                 250                 255     


Ala Ala Ala Tyr Tyr Val Gly Tyr Leu Gln Pro Arg Thr Phe Leu Leu 
            260                 265                 270         


Lys Tyr Asn Glu Asn Gly Thr Ile Thr Asp Ala Val Asp Cys Ala Leu 
        275                 280                 285             


Asp Pro Leu Ser Glu Thr Lys Cys Thr Leu Lys Ser Phe Thr Val Glu 
    290                 295                 300                 


Lys Gly Ile Tyr Gln Thr Ser Asn Phe Arg Val Gln Pro Thr Glu Ser 
305                 310                 315                 320 


Ile Val Arg Phe Pro Asn Ile Thr Asn Leu Cys Pro Phe Gly Glu Val 
                325                 330                 335     


Phe Asn Ala Thr Arg Phe Ala Ser Val Tyr Ala Trp Asn Arg Lys Arg 
            340                 345                 350         


Ile Ser Asn Cys Val Ala Asp Tyr Ser Val Leu Tyr Asn Ser Ala Ser 
        355                 360                 365             


Phe Ser Thr Phe Lys Cys Tyr Gly Val Ser Pro Thr Lys Leu Asn Asp 
    370                 375                 380                 


Leu Cys Phe Thr Asn Val Tyr Ala Asp Ser Phe Val Ile Arg Gly Asp 
385                 390                 395                 400 


Glu Val Arg Gln Ile Ala Pro Gly Gln Thr Gly Lys Ile Ala Asp Tyr 
                405                 410                 415     


Asn Tyr Lys Leu Pro Asp Asp Phe Thr Gly Cys Val Ile Ala Trp Asn 
            420                 425                 430         


Ser Asn Asn Leu Asp Ser Lys Val Gly Gly Asn Tyr Asn Tyr Leu Tyr 
        435                 440                 445             


Arg Leu Phe Arg Lys Ser Asn Leu Lys Pro Phe Glu Arg Asp Ile Ser 
    450                 455                 460                 


Thr Glu Ile Tyr Gln Ala Gly Ser Thr Pro Cys Asn Gly Val Glu Gly 
465                 470                 475                 480 


Phe Asn Cys Tyr Phe Pro Leu Gln Ser Tyr Gly Phe Gln Pro Thr Asn 
                485                 490                 495     


Gly Val Gly Tyr Gln Pro Tyr Arg Val Val Val Leu Ser Phe Glu Leu 
            500                 505                 510         


Leu His Ala Pro Ala Thr Val Cys Gly Pro Lys Lys Ser Thr Asn Leu 
        515                 520                 525             


Val Lys Asn Lys Cys Val Asn Phe Asn Phe Asn Gly Leu Thr Gly Thr 
    530                 535                 540                 


Gly Val Leu Thr Glu Ser Asn Lys Lys Phe Leu Pro Phe Gln Gln Phe 
545                 550                 555                 560 


Gly Arg Asp Ile Ala Asp Thr Thr Asp Ala Val Arg Asp Pro Gln Thr 
                565                 570                 575     


Leu Glu Ile Leu Asp Ile Thr Pro Cys Ser Phe Gly Gly Val Ser Val 
            580                 585                 590         


Ile Thr Pro Gly Thr Asn Thr Ser Asn Gln Val Ala Val Leu Tyr Gln 
        595                 600                 605             


Asp Val Asn Cys Thr Glu Val Pro Val Ala Ile His Ala Asp Gln Leu 
    610                 615                 620                 


Thr Pro Thr Trp Arg Val Tyr Ser Thr Gly Ser Asn Val Phe Gln Thr 
625                 630                 635                 640 


Arg Ala Gly Cys Leu Ile Gly Ala Glu His Val Asn Asn Ser Tyr Glu 
                645                 650                 655     


Cys Asp Ile Pro Ile Gly Ala Gly Ile Cys Ala Ser Tyr Gln Thr Gln 
            660                 665                 670         


Thr Asn Ser Pro Arg Arg Ala Arg Ser Val Ala Ser Gln Ser Ile Ile 
        675                 680                 685             


Ala Tyr Thr Met Ser Leu Gly Ala Glu Asn Ser Val Ala Tyr Ser Asn 
    690                 695                 700                 


Asn Ser Ile Ala Ile Pro Thr Asn Phe Thr Ile Ser Val Thr Thr Glu 
705                 710                 715                 720 


Ile Leu Pro Val Ser Met Thr Lys Thr Ser Val Asp Cys Thr Met Tyr 
                725                 730                 735     


Ile Cys Gly Asp Ser Thr Glu Cys Ser Asn Leu Leu Leu Gln Tyr Gly 
            740                 745                 750         


Ser Phe Cys Thr Gln Leu Asn Arg Ala Leu Thr Gly Ile Ala Val Glu 
        755                 760                 765             


Gln Asp Lys Asn Thr Gln Glu Val Phe Ala Gln Val Lys Gln Ile Tyr 
    770                 775                 780                 


Lys Thr Pro Pro Ile Lys Asp Phe Gly Gly Phe Asn Phe Ser Gln Ile 
785                 790                 795                 800 


Leu Pro Asp Pro Ser Lys Pro Ser Lys Arg Ser Phe Ile Glu Asp Leu 
                805                 810                 815     


Leu Phe Asn Lys Val Thr Leu Ala Asp Ala Gly Phe Ile Lys Gln Tyr 
            820                 825                 830         


Gly Asp Cys Leu Gly Asp Ile Ala Ala Arg Asp Leu Ile Cys Ala Gln 
        835                 840                 845             


Lys Phe Asn Gly Leu Thr Val Leu Pro Pro Leu Leu Thr Asp Glu Met 
    850                 855                 860                 


Ile Ala Gln Tyr Thr Ser Ala Leu Leu Ala Gly Thr Ile Thr Ser Gly 
865                 870                 875                 880 


Trp Thr Phe Gly Ala Gly Ala Ala Leu Gln Ile Pro Phe Ala Met Gln 
                885                 890                 895     


Met Ala Tyr Arg Phe Asn Gly Ile Gly Val Thr Gln Asn Val Leu Tyr 
            900                 905                 910         


Glu Asn Gln Lys Leu Ile Ala Asn Gln Phe Asn Ser Ala Ile Gly Lys 
        915                 920                 925             


Ile Gln Asp Ser Leu Ser Ser Thr Ala Ser Ala Leu Gly Lys Leu Gln 
    930                 935                 940                 


Asp Val Val Asn Gln Asn Ala Gln Ala Leu Asn Thr Leu Val Lys Gln 
945                 950                 955                 960 


Leu Ser Ser Asn Phe Gly Ala Ile Ser Ser Val Leu Asn Asp Ile Leu 
                965                 970                 975     


Ser Arg Leu Asp Lys Val Glu Ala Glu Val Gln Ile Asp Arg Leu Ile 
            980                 985                 990         


Thr Gly Arg Leu Gln Ser Leu Gln  Thr Tyr Val Thr Gln  Gln Leu Ile 
        995                 1000                 1005             


Arg Ala  Ala Glu Ile Arg Ala  Ser Ala Asn Leu Ala  Ala Thr Lys 
    1010                 1015                 1020             


Met Ser  Glu Cys Val Leu Gly  Gln Ser Lys Arg Val  Asp Phe Cys 
    1025                 1030                 1035             


Gly Lys  Gly Tyr His Leu Met  Ser Phe Pro Gln Ser  Ala Pro His 
    1040                 1045                 1050             


Gly Val  Val Phe Leu His Val  Thr Tyr Val Pro Ala  Gln Glu Lys 
    1055                 1060                 1065             


Asn Phe  Thr Thr Ala Pro Ala  Ile Cys His Asp Gly  Lys Ala His 
    1070                 1075                 1080             


Phe Pro  Arg Glu Gly Val Phe  Val Ser Asn Gly Thr  His Trp Phe 
    1085                 1090                 1095             


Val Thr  Gln Arg Asn Phe Tyr  Glu Pro Gln Ile Ile  Thr Thr Asp 
    1100                 1105                 1110             


Asn Thr  Phe Val Ser Gly Asn  Cys Asp Val Val Ile  Gly Ile Val 
    1115                 1120                 1125             


Asn Asn  Thr Val Tyr Asp Pro  Leu Gln Pro Glu Leu  Asp Ser Phe 
    1130                 1135                 1140             


Lys Glu  Glu Leu Asp Lys Tyr  Phe Lys Asn His Thr  Ser Pro Asp 
    1145                 1150                 1155             


Val Asp  Leu Gly Asp Ile Ser  Gly Ile Asn Ala Ser  Val Val Asn 
    1160                 1165                 1170             


Ile Gln  Lys Glu Ile Asp Arg  Leu Asn Glu Val Ala  Lys Asn Leu 
    1175                 1180                 1185             


Asn Glu  Ser Leu Ile Asp Leu  Gln Glu Leu Gly Lys  Tyr Glu Gln 
    1190                 1195                 1200             


Tyr Ile  Lys Trp Pro Trp Tyr  Ile His His His His  His His His 
    1205                 1210                 1215             


His His  His 
    1220     


<210>  13
<211>  993
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13
atgcaattgc ttcgttgttt cagtatattc tctgtaattg ccagcgttct agcacaggaa       60

ttaacgacga tatgcgaaca aatcccttcc ccgaccctag aatctactcc ctatagcctt      120

agtacaacaa ctatcctagc caatggtaaa gccatgcaag gcgtatttga atattacaaa      180

tctgttactt tcgtgtccaa ttgcggcagt catccgtcca cgaccagcaa gggcagtcct      240

ataaacacgc agtacgtctt taaggacaac agctcaacca tagagggcag atacccttat      300

gatgtgcccg attatgcgtt gcaagcgagt ggcggaggcg gaagtggtgg tggaggttcc      360

ggtggaggtg ggagtctcga gttcagagtt cagccaacag aatcaatcgt tcgtttccct      420

aatataacca atctgtgtcc ttttggtgaa gtgttcaatg caactagatt tgcatctgta      480

tacgcttgga atagaaagag aatttccaac tgcgtcgccg attacagtgt tctctacaac      540

tctgcttcat tttctacttt taagtgttac ggtgtgtctc caacaaagct aaatgatctt      600

tgttttacaa acgtttacgc cgactctttc gtaatcagag gggatgaagt tagacaaatt      660

gcgccaggtc agactggaaa aatcgcagat tacaactata aactacctga cgacttcact      720

ggttgcgtca ttgcttggaa cagtaacaac ttggattcca aggtcggtgg caactataac      780

tacttataca gattattcag aaaatcaaac ttgaagccat tcgagagaga tattagcacc      840

gaaatctacc aagctggatc aacaccatgc aatggtgttg agggcttcaa ttgttatttc      900

cctttgcaat catacggatt ccaaccaaca aacggcgtgg ggtaccaacc ataccgtgtt      960

catcatcatc atcaccatca ccatcatcac taa                                   993


<210>  14
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Met Gln Leu Leu Arg Cys Phe Ser Ile Phe Ser Val Ile Ala Ser Val 
1               5                   10                  15      


Leu Ala Gln Glu Leu Thr Thr Ile Cys Glu Gln Ile Pro Ser Pro Thr 
            20                  25                  30          


Leu Glu Ser Thr Pro Tyr Ser Leu Ser Thr Thr Thr Ile Leu Ala Asn 
        35                  40                  45              


Gly Lys Ala Met Gln Gly Val Phe Glu Tyr Tyr Lys Ser Val Thr Phe 
    50                  55                  60                  


Val Ser Asn Cys Gly Ser His Pro Ser Thr Thr Ser Lys Gly Ser Pro 
65                  70                  75                  80  


Ile Asn Thr Gln Tyr Val Phe Lys Asp Asn Ser Ser Thr Ile Glu Gly 
                85                  90                  95      


Arg Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Leu Gln Ala Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Leu Glu Phe 
        115                 120                 125             


Arg Val Gln Pro Thr Glu Ser Ile Val Arg Phe Pro Asn Ile Thr Asn 
    130                 135                 140                 


Leu Cys Pro Phe Gly Glu Val Phe Asn Ala Thr Arg Phe Ala Ser Val 
145                 150                 155                 160 


Tyr Ala Trp Asn Arg Lys Arg Ile Ser Asn Cys Val Ala Asp Tyr Ser 
                165                 170                 175     


Val Leu Tyr Asn Ser Ala Ser Phe Ser Thr Phe Lys Cys Tyr Gly Val 
            180                 185                 190         


Ser Pro Thr Lys Leu Asn Asp Leu Cys Phe Thr Asn Val Tyr Ala Asp 
        195                 200                 205             


Ser Phe Val Ile Arg Gly Asp Glu Val Arg Gln Ile Ala Pro Gly Gln 
    210                 215                 220                 


Thr Gly Lys Ile Ala Asp Tyr Asn Tyr Lys Leu Pro Asp Asp Phe Thr 
225                 230                 235                 240 


Gly Cys Val Ile Ala Trp Asn Ser Asn Asn Leu Asp Ser Lys Val Gly 
                245                 250                 255     


Gly Asn Tyr Asn Tyr Leu Tyr Arg Leu Phe Arg Lys Ser Asn Leu Lys 
            260                 265                 270         


Pro Phe Glu Arg Asp Ile Ser Thr Glu Ile Tyr Gln Ala Gly Ser Thr 
        275                 280                 285             


Pro Cys Asn Gly Val Glu Gly Phe Asn Cys Tyr Phe Pro Leu Gln Ser 
    290                 295                 300                 


Tyr Gly Phe Gln Pro Thr Asn Gly Val Gly Tyr Gln Pro Tyr Arg Val 
305                 310                 315                 320 


His His His His His His His His His His 
                325                 330 


<210>  15
<211>  1358
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15
gaattcgcca ccatgtatcc atacgatgtt ccagattacg caggaccagg accaggcact       60

agttcagata acgggccaca gaaccagaga aacgctccta gaatcacttt cggcgggcct      120

tcagattcta cgggctctaa tcaaaatggt gaaagatcgg gagcacgatc aaagcaacgt      180

agacctcaag gcttgccaaa caacaccgcc tcttggttca cagctttaac acaacatggt      240

aaggaagatt tgaagttccc aagaggccaa ggtgttccta ttaatacaaa tagctcacca      300

gatgatcaaa ttggttacta ccgtagagcg actagacgta ttaggggcgg ggatgggaag      360

atgaaagact tgtctcctag atggtacttt tactacctgg gtacaggacc agaggctgga      420

ttaccttacg gtgcaaacaa agacggcatc atatgggtgg ctactgaagg tgcgcttaat      480

acaccaaaag accatatcgg taccagaaat ccagcgaaca atgcagcaat cgtgttgcaa      540

cttcctcaag gtacaacttt gccaaagggt ttttacgctg aaggttcacg tggtgggagc      600

caagcatcct caagatccag ttcaagatct agaaattcat ctagaaactc cacaccaggt      660

tcatctagag gaacctcccc agctagaatg gctggaaacg gcggcgatgc tgcattagcc      720

ttgttgctat tggatagact aaaccaatta gagagtaaaa tgtctggaaa gggtcagcaa      780

caacagggtc aaacagttac caaaaagtca gccgcagagg cctctaaaaa gccaagacag      840

aagagaactg ctaccaaagc ctacaacgtt actcaggcct tcggtagaag aggtcctgag      900

cagacacaag ggaacttcgg tgatcaggaa ttgatcagac agggtacaga ctataagcat      960

tggccacaaa ttgcacaatt cgcaccgtca gcttccgctt ttttcggtat gagtcggatt     1020

ggtatggaag tcactccttc tggaacatgg ttaacatata ctggtgccat aaagctagat     1080

gacaaggacc caaacttcaa ggaccaagtc attctgctta acaagcatat cgatgcatac     1140

aagacttttc cacctacaga acctaaaaaa gataaaaaaa aaaaggccga tgaaactcaa     1200

gctctaccac aaagacaaaa aaagcaacaa acagtaacct tactcccagc agcggacctc     1260

gacgatttct ctaagcaact gcaacaatct atgtctagtg cagattccac acaggctcat     1320

catcatcacc atcaccacca ccatcactaa gcggccgc                             1358


<210>  16
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Met Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Gly Pro Gly Pro Gly Thr 
1               5                   10                  15      


Ser Ser Asp Asn Gly Pro Gln Asn Gln Arg Asn Ala Pro Arg Ile Thr 
            20                  25                  30          


Phe Gly Gly Pro Ser Asp Ser Thr Gly Ser Asn Gln Asn Gly Glu Arg 
        35                  40                  45              


Ser Gly Ala Arg Ser Lys Gln Arg Arg Pro Gln Gly Leu Pro Asn Asn 
    50                  55                  60                  


Thr Ala Ser Trp Phe Thr Ala Leu Thr Gln His Gly Lys Glu Asp Leu 
65                  70                  75                  80  


Lys Phe Pro Arg Gly Gln Gly Val Pro Ile Asn Thr Asn Ser Ser Pro 
                85                  90                  95      


Asp Asp Gln Ile Gly Tyr Tyr Arg Arg Ala Thr Arg Arg Ile Arg Gly 
            100                 105                 110         


Gly Asp Gly Lys Met Lys Asp Leu Ser Pro Arg Trp Tyr Phe Tyr Tyr 
        115                 120                 125             


Leu Gly Thr Gly Pro Glu Ala Gly Leu Pro Tyr Gly Ala Asn Lys Asp 
    130                 135                 140                 


Gly Ile Ile Trp Val Ala Thr Glu Gly Ala Leu Asn Thr Pro Lys Asp 
145                 150                 155                 160 


His Ile Gly Thr Arg Asn Pro Ala Asn Asn Ala Ala Ile Val Leu Gln 
                165                 170                 175     


Leu Pro Gln Gly Thr Thr Leu Pro Lys Gly Phe Tyr Ala Glu Gly Ser 
            180                 185                 190         


Arg Gly Gly Ser Gln Ala Ser Ser Arg Ser Ser Ser Arg Ser Arg Asn 
        195                 200                 205             


Ser Ser Arg Asn Ser Thr Pro Gly Ser Ser Arg Gly Thr Ser Pro Ala 
    210                 215                 220                 


Arg Met Ala Gly Asn Gly Gly Asp Ala Ala Leu Ala Leu Leu Leu Leu 
225                 230                 235                 240 


Asp Arg Leu Asn Gln Leu Glu Ser Lys Met Ser Gly Lys Gly Gln Gln 
                245                 250                 255     


Gln Gln Gly Gln Thr Val Thr Lys Lys Ser Ala Ala Glu Ala Ser Lys 
            260                 265                 270         


Lys Pro Arg Gln Lys Arg Thr Ala Thr Lys Ala Tyr Asn Val Thr Gln 
        275                 280                 285             


Ala Phe Gly Arg Arg Gly Pro Glu Gln Thr Gln Gly Asn Phe Gly Asp 
    290                 295                 300                 


Gln Glu Leu Ile Arg Gln Gly Thr Asp Tyr Lys His Trp Pro Gln Ile 
305                 310                 315                 320 


Ala Gln Phe Ala Pro Ser Ala Ser Ala Phe Phe Gly Met Ser Arg Ile 
                325                 330                 335     


Gly Met Glu Val Thr Pro Ser Gly Thr Trp Leu Thr Tyr Thr Gly Ala 
            340                 345                 350         


Ile Lys Leu Asp Asp Lys Asp Pro Asn Phe Lys Asp Gln Val Ile Leu 
        355                 360                 365             


Leu Asn Lys His Ile Asp Ala Tyr Lys Thr Phe Pro Pro Thr Glu Pro 
    370                 375                 380                 


Lys Lys Asp Lys Lys Lys Lys Ala Asp Glu Thr Gln Ala Leu Pro Gln 
385                 390                 395                 400 


Arg Gln Lys Lys Gln Gln Thr Val Thr Leu Leu Pro Ala Ala Asp Leu 
                405                 410                 415     


Asp Asp Phe Ser Lys Gln Leu Gln Gln Ser Met Ser Ser Ala Asp Ser 
            420                 425                 430         


Thr Gln Ala His His His His His His His His His His 
        435                 440                 445 


