                               SEQUENCE LISTING

<110> THERADAPTIVE, INC.
 
<120> COMPOSITIONS AND METHODS FOR TARGETED THERAPEUTIC DELIVERY TO 
      BONE

<130> 50222-705.601

<140>
<141>

<150> 63/010,639
<151> 2020-04-15

<160> 711   

<170> PatentIn version 3.5

<210> 1
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
1               5                   10          


<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser 
1               5                   10          


<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr 
1               5                   10          


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
1               5                   10          


<210> 5
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ile Leu Ala Glu Thr Thr His His Arg Pro Trp Ser 
1               5                   10          


<210> 6
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr 
1               5                   10          


<210> 7
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
1               5                   10          


<210> 8
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Val Leu Gly Asp Thr Thr His His Lys Pro Trp Thr 
1               5                   10          


<210> 9
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Ile Val Ala Asp Ser Thr His His Arg Pro Trp Thr 
1               5                   10          


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser 
1               5                   10      


<210> 11
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Thr Ser Gly Gly Glu Ser Thr His His Arg Pro Ser 
1               5                   10          


<210> 12
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Thr Ser Gly Gly Glu Ser Ser His His Lys Pro Ser 
1               5                   10          


<210> 13
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 13
Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser 
1               5                   10          


<210> 14
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 14
Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr 
1               5                   10              


<210> 15
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr 
1               5                   10          


<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Gly Ala Ala Asp Thr Thr His His Arg Pro Val Thr 
1               5                   10          


<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 17
Ala Gly Ala Asp Thr Thr His His Arg Pro Val Thr 
1               5                   10          


<210> 18
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 18
Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr 
1               5                   10          


<210> 19
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr 
1               5                   10          


<210> 20
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 20
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser 
            20                  


<210> 21
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr 
        35      


<210> 22
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
    50                  55                  60  


<210> 23
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr 
            20                  


<210> 24
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
    50                  55                  60  


<210> 25
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly 
            20                  


<210> 26
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 26
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr 
        35      


<210> 27
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
    50                  55                  60  


<210> 28
<211> 84
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 28
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
    50                  55                  60                  


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
65                  70                  75                  80  


Arg Pro Trp Thr 
                


<210> 29
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 29
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Thr Ser Gly Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Ser Thr Ser Gly Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Ser Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser Gly 
        35                  40                  45              


Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr 
    50                  55                  60  


<210> 30
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Gly Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Val Thr Ala Gly Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Val Thr Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr 
        35                  40                  45              


Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr 
    50                  55                  60  


<210> 31
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 31
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Leu Leu Ala Asp Thr 
1               5                   10                  15      


Thr His His Arg Pro Trp Thr Thr Ser Gly Gly Glu Ser Thr His His 
            20                  25                  30          


Arg Pro Ser Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Thr 
        35                  40                  45              


Ser Gly Gly Glu Ser Ser His His Lys Pro Ser Gly Ala Ala Asp Thr 
    50                  55                  60                  


Thr His His Arg Pro Val Thr Thr Gly Ser Gly Asp Ser Ser His His 
65                  70                  75                  80  


Arg Pro Ser Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr 
                85                  90                  95      


Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr 
            100                 105             


<210> 32
<211> 114
<212> PRT
<213> Homo sapiens

<400> 32
Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg 
        


<210> 33
<211> 37
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 33
Thr Gly Gly Ser Gly Glu Gly Gly Thr Gly Ala Ser Thr Gly Gly Ser 
1               5                   10                  15      


Ala Gly Thr Gly Gly Ser Gly Gly Thr Thr Ser Gly Glu Ala Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Gly 
        35          


<210> 34
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gly Ala Gly Thr Gly 
1               5   


<210> 35
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, L, I, G, S, T or A

<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, V, Q, T, S, G or A

<220>
<221> MOD_RES
<222> (3)..(3)
<223> G, A, V or S

<220>
<221> MOD_RES
<222> (4)..(4)
<223> E, D, L or G

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, T, P T, E or D

<220>
<221> MOD_RES
<222> (6)..(6)
<223> T or S

<220>
<221> MOD_RES
<222> (7)..(7)
<223> H, T or S

<220>
<221> MOD_RES
<222> (8)..(8)
<223> H or T

<220>
<221> MOD_RES
<222> (9)..(9)
<223> R, S, K, P or H

<220>
<221> MOD_RES
<222> (10)..(10)
<223> P, S, R or K

<220>
<221> MOD_RES
<222> (11)..(11)
<223> W, F, S, P, V, A or G

<220>
<221> MOD_RES
<222> (12)..(12)
<223> absent or is S, T G, or A

<400> 35
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10          


<210> 36
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr 
1               5                   10          


<210> 37
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 37
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr 
    50                  55                  60  


<210> 38
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 38
Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr 
    50                  55                  60  


<210> 39
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 39
Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr 
    50                  55                  60  


<210> 40
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr 
            20                  


<210> 41
<211> 36
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 41
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr 
        35      


<210> 42
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 42
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
    50                  55                  60  


<210> 43
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 43
Ser Thr Ser Gly Ser Thr Val Ile Gly Glu Ser Thr His His Arg Pro 
1               5                   10                  15      


Trp Ser Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr Ile Leu 
            20                  25                  30          


Ala Glu Ser Thr His His Lys Pro Trp Thr Ile Leu Ala Glu Thr Thr 
        35                  40                  45              


His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His Lys Pro 
    50                  55                  60                  


Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Val Leu 
65                  70                  75                  80  


Gly Asp Thr Thr His His Lys Pro Trp Thr Ile Val Ala Asp Ser Thr 
                85                  90                  95      


His His Arg Pro Trp Thr Gly Gln Val Leu Pro Thr Thr Thr Pro Ser 
            100                 105                 110         


Ser Pro Ser Thr Thr Ser Gly Ser 
        115                 120 


<210> 44
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Gly Gln Val Leu Pro Thr Thr Thr Pro Ser Ser Pro 
1               5                   10          


<210> 45
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Gly Ser Gly Ala Thr Gly 
1               5       


<210> 46
<211> 53
<212> PRT
<213> Homo sapiens

<400> 46
Asn Ser Asp Ser Glu Cys Pro Leu Ser His Asp Gly Tyr Cys Leu His 
1               5                   10                  15      


Asp Gly Val Cys Met Tyr Ile Glu Ala Leu Asp Lys Tyr Ala Cys Asn 
            20                  25                  30          


Cys Val Val Gly Tyr Ile Gly Glu Arg Cys Gln Tyr Arg Asp Leu Lys 
        35                  40                  45              


Trp Trp Glu Leu Arg 
    50              


<210> 47
<211> 66
<212> PRT
<213> Homo sapiens

<400> 47
Glu Glu Ala Glu Ile Pro Arg Glu Val Ile Glu Arg Leu Ala Arg Ser 
1               5                   10                  15      


Gln Ile His Ser Ile Arg Asp Leu Gln Arg Leu Leu Glu Ile Asp Ser 
            20                  25                  30          


Val Gly Ser Glu Asp Ser Leu Asp Thr Ser Leu Arg Ala His Gly Val 
        35                  40                  45              


His Ala Thr Lys His Val Pro Glu Lys Arg Pro Leu Pro Ile Arg Arg 
    50                  55                  60                  


Lys Arg 
65      


<210> 48
<211> 70
<212> PRT
<213> Homo sapiens

<400> 48
Gly Pro Glu Thr Leu Cys Gly Ala Glu Leu Val Asp Ala Leu Gln Phe 
1               5                   10                  15      


Val Cys Gly Asp Arg Gly Phe Tyr Phe Asn Lys Pro Thr Gly Tyr Gly 
            20                  25                  30          


Ser Ser Ser Arg Arg Ala Pro Gln Thr Gly Ile Val Asp Glu Cys Cys 
        35                  40                  45              


Phe Arg Ser Cys Asp Leu Arg Arg Leu Glu Met Tyr Cys Ala Pro Leu 
    50                  55                  60                  


Lys Pro Ala Lys Ser Ala 
65                  70  


<210> 49
<211> 140
<212> PRT
<213> Homo sapiens

<400> 49
Phe Asn Leu Pro Pro Gly Asn Tyr Lys Lys Pro Lys Leu Leu Tyr Cys 
1               5                   10                  15      


Ser Asn Gly Gly His Phe Leu Arg Ile Leu Pro Asp Gly Thr Val Asp 
            20                  25                  30          


Gly Thr Arg Asp Arg Ser Asp Gln His Ile Gln Leu Gln Leu Ser Ala 
        35                  40                  45              


Glu Ser Val Gly Glu Val Tyr Ile Lys Ser Thr Glu Thr Gly Gln Tyr 
    50                  55                  60                  


Leu Ala Met Asp Thr Asp Gly Leu Leu Tyr Gly Ser Gln Thr Pro Asn 
65                  70                  75                  80  


Glu Glu Cys Leu Phe Leu Glu Arg Leu Glu Glu Asn His Tyr Asn Thr 
                85                  90                  95      


Tyr Ile Ser Lys Lys His Ala Glu Lys Asn Trp Phe Val Gly Leu Lys 
            100                 105                 110         


Lys Asn Gly Ser Cys Lys Arg Gly Pro Arg Thr His Tyr Gly Gln Lys 
        115                 120                 125             


Ala Ile Leu Phe Leu Pro Leu Pro Val Ser Ser Asp 
    130                 135                 140 


<210> 50
<211> 146
<212> PRT
<213> Homo sapiens

<400> 50
Pro Ala Leu Pro Glu Asp Gly Gly Ser Gly Ala Phe Pro Pro Gly His 
1               5                   10                  15      


Phe Lys Asp Pro Lys Arg Leu Tyr Cys Lys Asn Gly Gly Phe Phe Leu 
            20                  25                  30          


Arg Ile His Pro Asp Gly Arg Val Asp Gly Val Arg Glu Lys Ser Asp 
        35                  40                  45              


Pro His Ile Lys Leu Gln Leu Gln Ala Glu Glu Arg Gly Val Val Ser 
    50                  55                  60                  


Ile Lys Gly Val Cys Ala Asn Arg Tyr Leu Ala Met Lys Glu Asp Gly 
65                  70                  75                  80  


Arg Leu Leu Ala Ser Lys Cys Val Thr Asp Glu Cys Phe Phe Phe Glu 
                85                  90                  95      


Arg Leu Glu Ser Asn Asn Tyr Asn Thr Tyr Arg Ser Arg Lys Tyr Thr 
            100                 105                 110         


Ser Trp Tyr Val Ala Leu Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser 
        115                 120                 125             


Lys Thr Gly Pro Gly Gln Lys Ala Ile Leu Phe Leu Pro Met Ser Ala 
    130                 135                 140                 


Lys Ser 
145     


<210> 51
<211> 180
<212> PRT
<213> Homo sapiens

<400> 51
Glu Glu Asn Val Asp Phe Arg Ile His Val Glu Asn Gln Thr Arg Ala 
1               5                   10                  15      


Arg Asp Asp Val Ser Arg Lys Gln Leu Arg Leu Tyr Gln Leu Tyr Ser 
            20                  25                  30          


Arg Thr Ser Gly Lys His Ile Gln Val Leu Gly Arg Arg Ile Ser Ala 
        35                  40                  45              


Arg Gly Glu Asp Gly Asp Lys Tyr Ala Gln Leu Leu Val Glu Thr Asp 
    50                  55                  60                  


Thr Phe Gly Ser Gln Val Arg Ile Lys Gly Lys Glu Thr Glu Phe Tyr 
65                  70                  75                  80  


Leu Cys Met Asn Arg Lys Gly Lys Leu Val Gly Lys Pro Asp Gly Thr 
                85                  90                  95      


Ser Lys Glu Cys Val Phe Ile Glu Lys Val Leu Glu Asn Asn Tyr Thr 
            100                 105                 110         


Ala Leu Met Ser Ala Lys Tyr Ser Gly Trp Tyr Val Gly Phe Thr Lys 
        115                 120                 125             


Lys Gly Arg Pro Arg Lys Gly Pro Lys Thr Arg Glu Asn Gln Gln Asp 
    130                 135                 140                 


Val His Phe Met Lys Arg Tyr Pro Lys Gly Gln Pro Glu Leu Gln Lys 
145                 150                 155                 160 


Pro Phe Lys Tyr Thr Thr Val Thr Lys Arg Ser Arg Arg Ile Arg Pro 
                165                 170                 175     


Thr His Pro Ala 
            180 


<210> 52
<211> 137
<212> PRT
<213> Homo sapiens

<400> 52
Glu Asn Ser Thr Ser Pro Leu Ser Ala Asp Pro Pro Val Ala Ala Ala 
1               5                   10                  15      


Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
            20                  25                  30          


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
        35                  40                  45              


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
    50                  55                  60                  


Leu Ala Val Val Ala Ala Ser Gln Lys Lys Gln Ala Ile Thr Ala Leu 
65                  70                  75                  80  


Val Val Val Ser Ile Val Ala Leu Ala Val Leu Ile Ile Thr Cys Val 
                85                  90                  95      


Leu Ile His Cys Cys Gln Val Arg Lys His Cys Glu Trp Cys Arg Ala 
            100                 105                 110         


Leu Ile Cys Arg His Glu Lys Pro Ser Ala Leu Leu Lys Gly Arg Thr 
        115                 120                 125             


Ala Cys Cys His Ser Glu Thr Val Val 
    130                 135         


<210> 53
<211> 112
<212> PRT
<213> Homo sapiens

<400> 53
Ala Leu Asp Thr Asn Tyr Cys Phe Ser Ser Thr Glu Lys Asn Cys Cys 
1               5                   10                  15      


Val Arg Gln Leu Tyr Ile Asp Phe Arg Lys Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Ile His Glu Pro Lys Gly Tyr His Ala Asn Phe Cys Leu Gly Pro Cys 
        35                  40                  45              


Pro Tyr Ile Trp Ser Leu Asp Thr Gln Tyr Ser Lys Val Leu Ala Leu 
    50                  55                  60                  


Tyr Asn Gln His Asn Pro Gly Ala Ser Ala Ala Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Ala Leu Glu Pro Leu Pro Ile Val Tyr Tyr Val Gly Arg Lys Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Ile Val Arg Ser Cys Lys Cys Ser 
            100                 105                 110         


<210> 54
<211> 112
<212> PRT
<213> Homo sapiens

<400> 54
Ala Leu Asp Thr Asn Tyr Cys Phe Arg Asn Leu Glu Glu Asn Cys Cys 
1               5                   10                  15      


Val Arg Pro Leu Tyr Ile Asp Phe Arg Gln Asp Leu Gly Trp Lys Trp 
            20                  25                  30          


Val His Glu Pro Lys Gly Tyr Tyr Ala Asn Phe Cys Ser Gly Pro Cys 
        35                  40                  45              


Pro Tyr Leu Arg Ser Ala Asp Thr Thr His Ser Thr Val Leu Gly Leu 
    50                  55                  60                  


Tyr Asn Thr Leu Asn Pro Glu Ala Ser Ala Ser Pro Cys Cys Val Pro 
65                  70                  75                  80  


Gln Asp Leu Glu Pro Leu Thr Ile Leu Tyr Tyr Val Gly Arg Thr Pro 
                85                  90                  95      


Lys Val Glu Gln Leu Ser Asn Met Val Val Lys Ser Cys Lys Cys Ser 
            100                 105                 110         


<210> 55
<211> 139
<212> PRT
<213> Homo sapiens

<400> 55
Ala Val Arg Pro Leu Arg Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu 
1               5                   10                  15      


Pro Gln Ala Asn Arg Leu Pro Gly Ile Phe Asp Asp Val His Gly Ser 
            20                  25                  30          


His Gly Arg Gln Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              


Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Met Pro 
                85                  90                  95      


Asp Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr 
            100                 105                 110         


Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His 
        115                 120                 125             


Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
    130                 135                 


<210> 56
<211> 139
<212> PRT
<213> Homo sapiens

<400> 56
Ala Val Arg Pro Leu Arg Arg Arg Gln Pro Lys Lys Ser Asn Glu Leu 
1               5                   10                  15      


Pro Gln Ala Asn Arg Leu Pro Gly Ile Phe Asp Asp Val Arg Gly Ser 
            20                  25                  30          


His Gly Arg Gln Val Cys Arg Arg His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              


Asp Leu Gly Trp Leu Asp Trp Val Ile Ala Pro Gln Gly Tyr Ser Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ser Phe Pro Leu Asp Ser Cys Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Leu Gln Ser Leu Val His Leu Met Lys Pro 
                85                  90                  95      


Asn Ala Val Pro Lys Ala Cys Cys Ala Pro Thr Lys Leu Ser Ala Thr 
            100                 105                 110         


Ser Val Leu Tyr Tyr Asp Ser Ser Asn Asn Val Ile Leu Arg Lys His 
        115                 120                 125             


Arg Asn Met Val Val Lys Ala Cys Gly Cys His 
    130                 135                 


<210> 57
<211> 110
<212> PRT
<213> Homo sapiens

<400> 57
Gln Trp Ile Glu Pro Arg Asn Cys Ala Arg Arg Tyr Leu Lys Val Asp 
1               5                   10                  15      


Phe Ala Asp Ile Gly Trp Ser Glu Trp Ile Ile Ser Pro Lys Ser Phe 
            20                  25                  30          


Asp Ala Tyr Tyr Cys Ser Gly Ala Cys Gln Phe Pro Met Pro Lys Ser 
        35                  40                  45              


Leu Lys Pro Ser Asn His Ala Thr Ile Gln Ser Ile Val Arg Ala Val 
    50                  55                  60                  


Gly Val Val Pro Gly Ile Pro Glu Pro Cys Cys Val Pro Glu Lys Met 
65                  70                  75                  80  


Ser Ser Leu Ser Ile Leu Phe Phe Asp Glu Asn Lys Asn Val Val Leu 
                85                  90                  95      


Lys Val Tyr Pro Asn Met Thr Val Glu Ser Cys Ala Cys Arg 
            100                 105                 110 


<210> 58
<211> 116
<212> PRT
<213> Homo sapiens

<400> 58
Ser Pro Lys His His Ser Gln Arg Ala Arg Lys Lys Asn Lys Asn Cys 
1               5                   10                  15      


Arg Arg His Ser Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
            20                  25                  30          


Trp Ile Val Ala Pro Pro Gly Tyr Gln Ala Phe Tyr Cys His Gly Asp 
        35                  40                  45              


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
    50                  55                  60                  


Val Gln Thr Leu Val Asn Ser Val Asn Ser Ser Ile Pro Lys Ala Cys 
65                  70                  75                  80  


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
                85                  90                  95      


Tyr Asp Lys Val Val Leu Lys Asn Tyr Gln Glu Met Val Val Glu Gly 
            100                 105                 110         


Cys Gly Cys Arg 
        115     


<210> 59
<211> 138
<212> PRT
<213> Homo sapiens

<400> 59
Ala Ala Asn Lys Arg Lys Asn Gln Asn Arg Asn Lys Ser Ser Ser His 
1               5                   10                  15      


Gln Asp Ser Ser Arg Met Ser Ser Val Gly Asp Tyr Asn Thr Ser Glu 
            20                  25                  30          


Gln Lys Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg Asp 
        35                  40                  45              


Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala Phe 
    50                  55                  60                  


Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn Ala 
65                  70                  75                  80  


Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu Met Phe Pro Asp 
                85                  90                  95      


His Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile Ser 
            100                 105                 110         


Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr Arg 
        115                 120                 125             


Asn Met Val Val Arg Ser Cys Gly Cys His 
    130                 135             


<210> 60
<211> 139
<212> PRT
<213> Homo sapiens

<400> 60
Ser Ala Ser Ser Arg Arg Arg Gln Gln Ser Arg Asn Arg Ser Thr Gln 
1               5                   10                  15      


Ser Gln Asp Val Ala Arg Val Ser Ser Ala Ser Asp Tyr Asn Ser Ser 
            20                  25                  30          


Glu Leu Lys Thr Ala Cys Arg Lys His Glu Leu Tyr Val Ser Phe Gln 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Lys Gly Tyr Ala Ala 
    50                  55                  60                  


Asn Tyr Cys Asp Gly Glu Cys Ser Phe Pro Leu Asn Ala His Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Leu Met Asn Pro 
                85                  90                  95      


Glu Tyr Val Pro Lys Pro Cys Cys Ala Pro Thr Lys Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Asn Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210> 61
<211> 139
<212> PRT
<213> Homo sapiens

<400> 61
Ser Thr Gly Ser Lys Gln Arg Ser Gln Asn Arg Ser Lys Thr Pro Lys 
1               5                   10                  15      


Asn Gln Glu Ala Leu Arg Met Ala Asn Val Ala Glu Asn Ser Ser Ser 
            20                  25                  30          


Asp Gln Arg Gln Ala Cys Lys Lys His Glu Leu Tyr Val Ser Phe Arg 
        35                  40                  45              


Asp Leu Gly Trp Gln Asp Trp Ile Ile Ala Pro Glu Gly Tyr Ala Ala 
    50                  55                  60                  


Tyr Tyr Cys Glu Gly Glu Cys Ala Phe Pro Leu Asn Ser Tyr Met Asn 
65                  70                  75                  80  


Ala Thr Asn His Ala Ile Val Gln Thr Leu Val His Phe Ile Asn Pro 
                85                  90                  95      


Glu Thr Val Pro Lys Pro Cys Cys Ala Pro Thr Gln Leu Asn Ala Ile 
            100                 105                 110         


Ser Val Leu Tyr Phe Asp Asp Ser Ser Asn Val Ile Leu Lys Lys Tyr 
        115                 120                 125             


Arg Asn Met Val Val Arg Ala Cys Gly Cys His 
    130                 135                 


<210> 62
<211> 110
<212> PRT
<213> Homo sapiens

<400> 62
Ser Ala Gly Ala Gly Ser His Cys Gln Lys Thr Ser Leu Arg Val Asn 
1               5                   10                  15      


Phe Glu Asp Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Lys Glu Tyr 
            20                  25                  30          


Glu Ala Tyr Glu Cys Lys Gly Gly Cys Phe Phe Pro Leu Ala Asp Asp 
        35                  40                  45              


Val Thr Pro Thr Lys His Ala Ile Val Gln Thr Leu Val His Leu Lys 
    50                  55                  60                  


Phe Pro Thr Lys Val Gly Lys Ala Cys Cys Val Pro Thr Lys Leu Ser 
65                  70                  75                  80  


Pro Ile Ser Val Leu Tyr Lys Asp Asp Met Gly Val Pro Thr Leu Lys 
                85                  90                  95      


Tyr His Tyr Glu Gly Met Ser Val Ala Glu Cys Gly Cys Arg 
            100                 105                 110 


<210> 63
<211> 108
<212> PRT
<213> Homo sapiens

<400> 63
Asn Ala Lys Gly Asn Tyr Cys Lys Arg Thr Pro Leu Tyr Ile Asp Phe 
1               5                   10                  15      


Lys Glu Ile Gly Trp Asp Ser Trp Ile Ile Ala Pro Pro Gly Tyr Glu 
            20                  25                  30          


Ala Tyr Glu Cys Arg Gly Val Cys Asn Tyr Pro Leu Ala Glu His Leu 
        35                  40                  45              


Thr Pro Thr Lys His Ala Ile Ile Gln Ala Leu Val His Leu Lys Asn 
    50                  55                  60                  


Ser Gln Lys Ala Ser Lys Ala Cys Cys Val Pro Thr Lys Leu Glu Pro 
65                  70                  75                  80  


Ile Ser Ile Leu Tyr Leu Asp Lys Gly Val Val Thr Tyr Lys Phe Lys 
                85                  90                  95      


Tyr Glu Gly Met Ala Val Ser Glu Cys Gly Cys Arg 
            100                 105             


<210> 64
<211> 109
<212> PRT
<213> Homo sapiens

<400> 64
Asn Leu Gly Leu Asp Cys Asp Glu His Ser Ser Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Gln Cys Glu 
        35                  40                  45              


Tyr Met Phe Met Gln Lys Tyr Pro His Thr His Leu Val Gln Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Asp Lys Gln Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Gly Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210> 65
<211> 129
<212> PRT
<213> Homo sapiens

<400> 65
Thr Ala Leu Ala Gly Thr Arg Thr Ala Gln Gly Ser Gly Gly Gly Ala 
1               5                   10                  15      


Gly Arg Gly His Gly Arg Arg Gly Arg Ser Arg Cys Ser Arg Lys Pro 
            20                  25                  30          


Leu His Val Asp Phe Lys Glu Leu Gly Trp Asp Asp Trp Ile Ile Ala 
        35                  40                  45              


Pro Leu Asp Tyr Glu Ala Tyr His Cys Glu Gly Leu Cys Asp Phe Pro 
    50                  55                  60                  


Leu Arg Ser His Leu Glu Pro Thr Asn His Ala Ile Ile Gln Thr Leu 
65                  70                  75                  80  


Leu Asn Ser Met Ala Pro Asp Ala Ala Pro Ala Ser Cys Cys Val Pro 
                85                  90                  95      


Ala Arg Leu Ser Pro Ile Ser Ile Leu Tyr Ile Asp Ala Ala Asn Asn 
            100                 105                 110         


Val Val Tyr Lys Gln Tyr Glu Asp Met Val Val Glu Ala Cys Gly Cys 
        115                 120                 125             


Arg 
    


<210> 66
<211> 120
<212> PRT
<213> Homo sapiens

<400> 66
Thr Ala Phe Ala Ser Arg His Gly Lys Arg His Gly Lys Lys Ser Arg 
1               5                   10                  15      


Leu Arg Cys Ser Lys Lys Pro Leu His Val Asn Phe Lys Glu Leu Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Tyr His Cys 
        35                  40                  45              


Glu Gly Val Cys Asp Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Ile Ile Gln Thr Leu Met Asn Ser Met Asp Pro Gly Ser Thr 
65                  70                  75                  80  


Pro Pro Ser Cys Cys Val Pro Thr Lys Leu Thr Pro Ile Ser Ile Leu 
                85                  90                  95      


Tyr Ile Asp Ala Gly Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210> 67
<211> 125
<212> PRT
<213> Homo sapiens

<400> 67
Gln Ala Asp Gly Ile Ser Ala Glu Val Thr Ala Ser Ser Ser Lys His 
1               5                   10                  15      


Ser Gly Pro Glu Asn Asn Gln Cys Ser Leu His Pro Phe Gln Ile Ser 
            20                  25                  30          


Phe Arg Gln Leu Gly Trp Asp His Trp Ile Ile Ala Pro Pro Phe Tyr 
        35                  40                  45              


Thr Pro Asn Tyr Cys Lys Gly Thr Cys Leu Arg Val Leu Arg Asp Gly 
    50                  55                  60                  


Leu Asn Ser Pro Asn His Ala Ile Ile Gln Asn Leu Ile Asn Gln Leu 
65                  70                  75                  80  


Val Asp Gln Ser Val Pro Arg Pro Ser Cys Val Pro Tyr Lys Tyr Val 
                85                  90                  95      


Pro Ile Ser Val Leu Met Ile Glu Ala Asn Gly Ser Ile Leu Tyr Lys 
            100                 105                 110         


Glu Tyr Glu Gly Met Ile Ala Glu Ser Cys Thr Cys Arg 
        115                 120                 125 


<210> 68
<211> 447
<212> PRT
<213> Homo sapiens

<400> 68
Ile Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser 
1               5                   10                  15      


Met Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu 
            20                  25                  30          


Leu Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu 
        35                  40                  45              


Gly Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu 
    50                  55                  60                  


Gly Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly 
                85                  90                  95      


Asp Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys 
            100                 105                 110         


Glu Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile 
        115                 120                 125             


Asp Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp 
    130                 135                 140                 


Lys Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp 
145                 150                 155                 160 


Val Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn 
                165                 170                 175     


Ser Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu 
            180                 185                 190         


Gly Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly 
        195                 200                 205             


Thr Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu 
    210                 215                 220                 


Asp Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu 
225                 230                 235                 240 


Asp Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys 
                245                 250                 255     


Asp Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys 
            260                 265                 270         


Glu Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu 
        275                 280                 285             


Tyr Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly 
    290                 295                 300                 


Asp Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp 
305                 310                 315                 320 


Asn Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu 
                325                 330                 335     


Ser Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala 
            340                 345                 350         


Val Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser 
        355                 360                 365             


Gly Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys 
    370                 375                 380                 


Glu Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys 
385                 390                 395                 400 


Thr Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu 
                405                 410                 415     


Pro Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser 
            420                 425                 430         


Asp Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly 
        435                 440                 445         


<210> 69
<211> 119
<212> PRT
<213> Homo sapiens

<400> 69
Asp Ala Glu Pro Val Leu Gly Gly Gly Pro Gly Gly Ala Cys Arg Ala 
1               5                   10                  15      


Arg Arg Leu Tyr Val Ser Phe Arg Glu Val Gly Trp His Arg Trp Val 
            20                  25                  30          


Ile Ala Pro Arg Gly Phe Leu Ala Asn Tyr Cys Gln Gly Gln Cys Ala 
        35                  40                  45              


Leu Pro Val Ala Leu Ser Gly Ser Gly Gly Pro Pro Ala Leu Asn His 
    50                  55                  60                  


Ala Val Leu Arg Ala Leu Met His Ala Ala Ala Pro Gly Ala Ala Asp 
65                  70                  75                  80  


Leu Pro Cys Cys Val Pro Ala Arg Leu Ser Pro Ile Ser Val Leu Phe 
                85                  90                  95      


Phe Asp Asn Ser Asp Asn Val Val Leu Arg Gln Tyr Glu Asp Met Val 
            100                 105                 110         


Val Asp Glu Cys Gly Cys Arg 
        115                 


<210> 70
<211> 114
<212> PRT
<213> Homo sapiens

<400> 70
Ala Ala Ile Pro Val Pro Lys Leu Ser Cys Lys Asn Leu Cys His Arg 
1               5                   10                  15      


His Gln Leu Phe Ile Asn Phe Arg Asp Leu Gly Trp His Lys Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Gly Phe Met Ala Asn Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Ser Leu Thr Ile Ser Leu Asn Ser Ser Asn Tyr Ala Phe Met Gln 
    50                  55                  60                  


Ala Leu Met His Ala Val Asp Pro Glu Ile Pro Gln Ala Val Cys Ile 
65                  70                  75                  80  


Pro Thr Lys Leu Ser Pro Ile Ser Met Leu Tyr Gln Asp Asn Asn Asp 
                85                  90                  95      


Asn Val Ile Leu Arg His Tyr Glu Asp Met Val Val Asp Glu Cys Gly 
            100                 105                 110         


Cys Gly 
        


<210> 71
<211> 120
<212> PRT
<213> Homo sapiens

<400> 71
Ala Pro Leu Ala Thr Arg Gln Gly Lys Arg Pro Ser Lys Asn Leu Lys 
1               5                   10                  15      


Ala Arg Cys Ser Arg Lys Ala Leu His Val Asn Phe Lys Asp Met Gly 
            20                  25                  30          


Trp Asp Asp Trp Ile Ile Ala Pro Leu Glu Tyr Glu Ala Phe His Cys 
        35                  40                  45              


Glu Gly Leu Cys Glu Phe Pro Leu Arg Ser His Leu Glu Pro Thr Asn 
    50                  55                  60                  


His Ala Val Ile Gln Thr Leu Met Asn Ser Met Asp Pro Glu Ser Thr 
65                  70                  75                  80  


Pro Pro Thr Cys Cys Val Pro Thr Arg Leu Ser Pro Ile Ser Ile Leu 
                85                  90                  95      


Phe Ile Asp Ser Ala Asn Asn Val Val Tyr Lys Gln Tyr Glu Asp Met 
            100                 105                 110         


Val Val Glu Ser Cys Gly Cys Arg 
        115                 120 


<210> 72

<400> 72
000


<210> 73
<211> 109
<212> PRT
<213> Homo sapiens

<400> 73
Asp Phe Gly Leu Asp Cys Asp Glu His Ser Thr Glu Ser Arg Cys Cys 
1               5                   10                  15      


Arg Tyr Pro Leu Thr Val Asp Phe Glu Ala Phe Gly Trp Asp Trp Ile 
            20                  25                  30          


Ile Ala Pro Lys Arg Tyr Lys Ala Asn Tyr Cys Ser Gly Glu Cys Glu 
        35                  40                  45              


Phe Val Phe Leu Gln Lys Tyr Pro His Thr His Leu Val His Gln Ala 
    50                  55                  60                  


Asn Pro Arg Gly Ser Ala Gly Pro Cys Cys Thr Pro Thr Lys Met Ser 
65                  70                  75                  80  


Pro Ile Asn Met Leu Tyr Phe Asn Gly Lys Glu Gln Ile Ile Tyr Gly 
                85                  90                  95      


Lys Ile Pro Ala Met Val Val Asp Arg Cys Gly Cys Ser 
            100                 105                 


<210> 74
<211> 114
<212> PRT
<213> Homo sapiens

<400> 74
Ala Arg Ala Arg Asn Gly Asp His Cys Pro Leu Gly Pro Gly Arg Cys 
1               5                   10                  15      


Cys Arg Leu His Thr Val Arg Ala Ser Leu Glu Asp Leu Gly Trp Ala 
            20                  25                  30          


Asp Trp Val Leu Ser Pro Arg Glu Val Gln Val Thr Met Cys Ile Gly 
        35                  40                  45              


Ala Cys Pro Ser Gln Phe Arg Ala Ala Asn Met His Ala Gln Ile Lys 
    50                  55                  60                  


Thr Ser Leu His Arg Leu Lys Pro Asp Thr Val Pro Ala Pro Cys Cys 
65                  70                  75                  80  


Val Pro Ala Ser Tyr Asn Pro Met Val Leu Ile Gln Lys Thr Asp Thr 
                85                  90                  95      


Gly Val Ser Leu Gln Thr Tyr Asp Asp Leu Leu Ala Lys Asp Cys His 
            100                 105                 110         


Cys Ile 
        


<210> 75
<211> 206
<212> PRT
<213> Homo sapiens

<400> 75
Ala Pro Met Ala Glu Gly Gly Gly Gln Asn His His Glu Val Val Lys 
1               5                   10                  15      


Phe Met Asp Val Tyr Gln Arg Ser Tyr Cys His Pro Ile Glu Thr Leu 
            20                  25                  30          


Val Asp Ile Phe Gln Glu Tyr Pro Asp Glu Ile Glu Tyr Ile Phe Lys 
        35                  40                  45              


Pro Ser Cys Val Pro Leu Met Arg Cys Gly Gly Cys Cys Asn Asp Glu 
    50                  55                  60                  


Gly Leu Glu Cys Val Pro Thr Glu Glu Ser Asn Ile Thr Met Gln Ile 
65                  70                  75                  80  


Met Arg Ile Lys Pro His Gln Gly Gln His Ile Gly Glu Met Ser Phe 
                85                  90                  95      


Leu Gln His Asn Lys Cys Glu Cys Arg Pro Lys Lys Asp Arg Ala Arg 
            100                 105                 110         


Gln Glu Lys Lys Ser Val Arg Gly Lys Gly Lys Gly Gln Lys Arg Lys 
        115                 120                 125             


Arg Lys Lys Ser Arg Tyr Lys Ser Trp Ser Val Tyr Val Gly Ala Arg 
    130                 135                 140                 


Cys Cys Leu Met Pro Trp Ser Leu Pro Gly Pro His Pro Cys Gly Pro 
145                 150                 155                 160 


Cys Ser Glu Arg Arg Lys His Leu Phe Val Gln Asp Pro Gln Thr Cys 
                165                 170                 175     


Lys Cys Ser Cys Lys Asn Thr Asp Ser Arg Cys Lys Ala Arg Gln Leu 
            180                 185                 190         


Glu Leu Asn Glu Arg Thr Cys Arg Cys Asp Lys Pro Arg Arg 
        195                 200                 205     


<210> 76
<211> 290
<212> PRT
<213> Homo sapiens

<400> 76
Phe Ser Leu Met Ser Leu Leu Glu Ser Leu Asp Pro Asp Trp Thr Pro 
1               5                   10                  15      


Asp Gln Tyr Asp Tyr Ser Tyr Glu Asp Tyr Asn Gln Glu Glu Asn Thr 
            20                  25                  30          


Ser Ser Thr Leu Thr His Ala Glu Asn Pro Asp Trp Tyr Tyr Thr Glu 
        35                  40                  45              


Asp Gln Ala Asp Pro Cys Gln Pro Asn Pro Cys Glu His Gly Gly Asp 
    50                  55                  60                  


Cys Leu Val His Gly Ser Thr Phe Thr Cys Ser Cys Leu Ala Pro Phe 
65                  70                  75                  80  


Ser Gly Asn Lys Cys Gln Lys Val Gln Asn Thr Cys Lys Asp Asn Pro 
                85                  90                  95      


Cys Gly Arg Gly Gln Cys Leu Ile Thr Gln Ser Pro Pro Tyr Tyr Arg 
            100                 105                 110         


Cys Val Cys Lys His Pro Tyr Thr Gly Pro Ser Cys Ser Gln Val Val 
        115                 120                 125             


Pro Val Cys Arg Pro Asn Pro Cys Gln Asn Gly Ala Thr Cys Ser Arg 
    130                 135                 140                 


His Lys Arg Arg Ser Lys Phe Thr Cys Ala Cys Pro Asp Gln Phe Lys 
145                 150                 155                 160 


Gly Lys Phe Cys Glu Ile Gly Ser Asp Asp Cys Tyr Val Gly Asp Gly 
                165                 170                 175     


Tyr Ser Tyr Arg Gly Lys Met Asn Arg Thr Val Asn Gln His Ala Cys 
            180                 185                 190         


Leu Tyr Trp Asn Ser His Leu Leu Leu Gln Glu Asn Tyr Asn Met Phe 
        195                 200                 205             


Met Glu Asp Ala Glu Thr His Gly Ile Gly Glu His Asn Phe Cys Arg 
    210                 215                 220                 


Asn Pro Asp Ala Asp Glu Lys Pro Trp Cys Phe Ile Lys Val Thr Asn 
225                 230                 235                 240 


Asp Lys Val Lys Trp Glu Tyr Cys Asp Val Ser Ala Cys Ser Ala Gln 
                245                 250                 255     


Asp Val Ala Tyr Pro Glu Glu Ser Pro Thr Glu Pro Ser Thr Lys Leu 
            260                 265                 270         


Pro Gly Phe Asp Ser Cys Gly Lys Thr Glu Ile Ala Glu Arg Lys Ile 
        275                 280                 285             


Lys Arg 
    290 


<210> 77
<211> 400
<212> PRT
<213> Homo sapiens

<400> 77
Ala Glu Val Lys Lys Pro Ala Ala Ala Ala Ala Pro Gly Thr Ala Glu 
1               5                   10                  15      


Lys Leu Ser Pro Lys Ala Ala Thr Leu Ala Glu Arg Ser Ala Gly Leu 
            20                  25                  30          


Ala Phe Ser Leu Tyr Gln Ala Met Ala Lys Asp Gln Ala Val Glu Asn 
        35                  40                  45              


Ile Leu Val Ser Pro Val Val Val Ala Ser Ser Leu Gly Leu Val Ser 
    50                  55                  60                  


Leu Gly Gly Lys Ala Thr Thr Ala Ser Gln Ala Lys Ala Val Leu Ser 
65                  70                  75                  80  


Ala Glu Gln Leu Arg Asp Glu Glu Val His Ala Gly Leu Gly Glu Leu 
                85                  90                  95      


Leu Arg Ser Leu Ser Asn Ser Thr Ala Arg Asn Val Thr Trp Lys Leu 
            100                 105                 110         


Gly Ser Arg Leu Tyr Gly Pro Ser Ser Val Ser Phe Ala Asp Asp Phe 
        115                 120                 125             


Val Arg Ser Ser Lys Gln His Tyr Asn Cys Glu His Ser Lys Ile Asn 
    130                 135                 140                 


Phe Arg Asp Lys Arg Ser Ala Leu Gln Ser Ile Asn Glu Trp Ala Ala 
145                 150                 155                 160 


Gln Thr Thr Asp Gly Lys Leu Pro Glu Val Thr Lys Asp Val Glu Arg 
                165                 170                 175     


Thr Asp Gly Ala Leu Leu Val Asn Ala Met Phe Phe Lys Pro His Trp 
            180                 185                 190         


Asp Glu Lys Phe His His Lys Met Val Asp Asn Arg Gly Phe Met Val 
        195                 200                 205             


Thr Arg Ser Tyr Thr Val Gly Val Met Met Met His Arg Thr Gly Leu 
    210                 215                 220                 


Tyr Asn Tyr Tyr Asp Asp Glu Lys Glu Lys Leu Gln Ile Val Glu Met 
225                 230                 235                 240 


Pro Leu Ala His Lys Leu Ser Ser Leu Ile Ile Leu Met Pro His His 
                245                 250                 255     


Val Glu Pro Leu Glu Arg Leu Glu Lys Leu Leu Thr Lys Glu Gln Leu 
            260                 265                 270         


Lys Ile Trp Met Gly Lys Met Gln Lys Lys Ala Val Ala Ile Ser Leu 
        275                 280                 285             


Pro Lys Gly Val Val Glu Val Thr His Asp Leu Gln Lys His Leu Ala 
    290                 295                 300                 


Gly Leu Gly Leu Thr Glu Ala Ile Asp Lys Asn Lys Ala Asp Leu Ser 
305                 310                 315                 320 


Arg Met Ser Gly Lys Lys Asp Leu Tyr Leu Ala Ser Val Phe His Ala 
                325                 330                 335     


Thr Ala Phe Glu Leu Asp Thr Asp Gly Asn Pro Phe Asp Gln Asp Ile 
            340                 345                 350         


Tyr Gly Arg Glu Glu Leu Arg Ser Pro Lys Leu Phe Tyr Ala Asp His 
        355                 360                 365             


Pro Phe Ile Phe Leu Val Arg Asp Thr Gln Ser Gly Ser Leu Leu Phe 
    370                 375                 380                 


Ile Gly Arg Leu Val Arg Pro Lys Gly Asp Lys Met Arg Asp Glu Leu 
385                 390                 395                 400 


<210> 78

<400> 78
000


<210> 79
<211> 163
<212> PRT
<213> Homo sapiens

<400> 79
Cys Asn Asp Met Thr Pro Glu Gln Met Ala Thr Asn Val Asn Cys Ser 
1               5                   10                  15      


Ser Pro Glu Arg His Thr Arg Ser Tyr Asp Tyr Met Glu Gly Gly Asp 
            20                  25                  30          


Ile Arg Val Arg Arg Leu Phe Cys Arg Thr Gln Trp Tyr Leu Arg Ile 
        35                  40                  45              


Asp Lys Arg Gly Lys Val Lys Gly Thr Gln Glu Met Lys Asn Asn Tyr 
    50                  55                  60                  


Asn Ile Met Glu Ile Arg Thr Val Ala Val Gly Ile Val Ala Ile Lys 
65                  70                  75                  80  


Gly Val Glu Ser Glu Phe Tyr Leu Ala Met Asn Lys Glu Gly Lys Leu 
                85                  90                  95      


Tyr Ala Lys Lys Glu Cys Asn Glu Asp Cys Asn Phe Lys Glu Leu Ile 
            100                 105                 110         


Leu Glu Asn His Tyr Asn Thr Tyr Ala Ser Ala Lys Trp Thr His Asn 
        115                 120                 125             


Gly Gly Glu Met Phe Val Ala Leu Asn Gln Lys Gly Ile Pro Val Arg 
    130                 135                 140                 


Gly Lys Lys Thr Lys Lys Glu Gln Lys Thr Ala His Phe Leu Pro Met 
145                 150                 155                 160 


Ala Ile Thr 
            


<210> 80
<211> 177
<212> PRT
<213> Homo sapiens

<400> 80
Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu Ser Leu Ile Ser Pro 
1               5                   10                  15      


Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr Pro Ser Asp Lys Pro 
            20                  25                  30          


Val Ala His Val Val Ala Asn Pro Gln Ala Glu Gly Gln Leu Gln Trp 
        35                  40                  45              


Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn Gly Val Glu Leu Arg 
    50                  55                  60                  


Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu Tyr Leu Ile Tyr Ser 
65                  70                  75                  80  


Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser Thr His Val Leu Leu 
                85                  90                  95      


Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr Gln Thr Lys Val Asn 
            100                 105                 110         


Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg Glu Thr Pro Glu Gly 
        115                 120                 125             


Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr Leu Gly Gly Val Phe 
    130                 135                 140                 


Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu Ile Asn Arg Pro Asp 
145                 150                 155                 160 


Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr Phe Gly Ile Ile Ala 
                165                 170                 175     


Leu 
    


<210> 81
<211> 243
<212> PRT
<213> Homo sapiens

<400> 81
Thr Asn Glu Leu Lys Gln Met Gln Asp Lys Tyr Ser Lys Ser Gly Ile 
1               5                   10                  15      


Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr Trp Asp Pro Asn Asp Glu 
            20                  25                  30          


Glu Ser Met Asn Ser Pro Cys Trp Gln Val Lys Trp Gln Leu Arg Gln 
        35                  40                  45              


Leu Val Arg Lys Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser Thr 
    50                  55                  60                  


Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly 
65                  70                  75                  80  


Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn 
                85                  90                  95      


Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys 
            100                 105                 110         


Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn 
        115                 120                 125             


Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr 
    130                 135                 140                 


Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu 
145                 150                 155                 160 


Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr 
                165                 170                 175     


Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys 
            180                 185                 190         


Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly 
        195                 200                 205             


Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn 
    210                 215                 220                 


Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe 
225                 230                 235                 240 


Leu Val Gly 
            


<210> 82
<211> 343
<212> PRT
<213> Homo sapiens

<400> 82
Ala Asn Ser Ser Gly Arg Trp Trp Gly Ile Val Asn Val Ala Ser Ser 
1               5                   10                  15      


Thr Asn Leu Leu Thr Asp Ser Lys Ser Leu Gln Leu Val Leu Glu Pro 
            20                  25                  30          


Ser Leu Gln Leu Leu Ser Arg Lys Gln Arg Arg Leu Ile Arg Gln Asn 
        35                  40                  45              


Pro Gly Ile Leu His Ser Val Ser Gly Gly Leu Gln Ser Ala Val Arg 
    50                  55                  60                  


Glu Cys Lys Trp Gln Phe Arg Asn Arg Arg Trp Asn Cys Pro Thr Ala 
65                  70                  75                  80  


Pro Gly Pro His Leu Phe Gly Lys Ile Val Asn Arg Gly Cys Arg Glu 
                85                  90                  95      


Thr Ala Phe Ile Phe Ala Ile Thr Ser Ala Gly Val Thr His Ser Val 
            100                 105                 110         


Ala Arg Ser Cys Ser Glu Gly Ser Ile Glu Ser Cys Thr Cys Asp Tyr 
        115                 120                 125             


Arg Arg Arg Gly Pro Gly Gly Pro Asp Trp His Trp Gly Gly Cys Ser 
    130                 135                 140                 


Asp Asn Ile Asp Phe Gly Arg Leu Phe Gly Arg Glu Phe Val Asp Ser 
145                 150                 155                 160 


Gly Glu Lys Gly Arg Asp Leu Arg Phe Leu Met Asn Leu His Asn Asn 
                165                 170                 175     


Glu Ala Gly Arg Thr Thr Val Phe Ser Glu Met Arg Gln Glu Cys Lys 
            180                 185                 190         


Cys His Gly Met Ser Gly Ser Cys Thr Val Arg Thr Cys Trp Met Arg 
        195                 200                 205             


Leu Pro Thr Leu Arg Ala Val Gly Asp Val Leu Arg Asp Arg Phe Asp 
    210                 215                 220                 


Gly Ala Ser Arg Val Leu Tyr Gly Asn Arg Gly Ser Asn Arg Ala Ser 
225                 230                 235                 240 


Arg Ala Glu Leu Leu Arg Leu Glu Pro Glu Asp Pro Ala His Lys Pro 
                245                 250                 255     


Pro Ser Pro His Asp Leu Val Tyr Phe Glu Lys Ser Pro Asn Phe Cys 
            260                 265                 270         


Thr Tyr Ser Gly Arg Leu Gly Thr Ala Gly Thr Ala Gly Arg Ala Cys 
        275                 280                 285             


Asn Ser Ser Ser Pro Ala Leu Asp Gly Cys Glu Leu Leu Cys Cys Gly 
    290                 295                 300                 


Arg Gly His Arg Thr Arg Thr Gln Arg Val Thr Glu Arg Cys Asn Cys 
305                 310                 315                 320 


Thr Phe His Trp Cys Cys His Val Ser Cys Arg Asn Cys Thr His Thr 
                325                 330                 335     


Arg Val Leu His Glu Cys Leu 
            340             


<210> 83
<211> 335
<212> PRT
<213> Homo sapiens

<400> 83
Ser Trp Trp Tyr Met Arg Ala Thr Gly Gly Ser Ser Arg Val Met Cys 
1               5                   10                  15      


Asp Asn Val Pro Gly Leu Val Ser Ser Gln Arg Gln Leu Cys His Arg 
            20                  25                  30          


His Pro Asp Val Met Arg Ala Ile Ser Gln Gly Val Ala Glu Trp Thr 
        35                  40                  45              


Ala Glu Cys Gln His Gln Phe Arg Gln His Arg Trp Asn Cys Asn Thr 
    50                  55                  60                  


Leu Asp Arg Asp His Ser Leu Phe Gly Arg Val Leu Leu Arg Ser Ser 
65                  70                  75                  80  


Arg Glu Ser Ala Phe Val Tyr Ala Ile Ser Ser Ala Gly Val Val Phe 
                85                  90                  95      


Ala Ile Thr Arg Ala Cys Ser Gln Gly Glu Val Lys Ser Cys Ser Cys 
            100                 105                 110         


Asp Pro Lys Lys Met Gly Ser Ala Lys Asp Ser Lys Gly Ile Phe Asp 
        115                 120                 125             


Trp Gly Gly Cys Ser Asp Asn Ile Asp Tyr Gly Ile Lys Phe Ala Arg 
    130                 135                 140                 


Ala Phe Val Asp Ala Lys Glu Arg Lys Gly Lys Asp Ala Arg Ala Leu 
145                 150                 155                 160 


Met Asn Leu His Asn Asn Arg Ala Gly Arg Lys Ala Val Lys Arg Phe 
                165                 170                 175     


Leu Lys Gln Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Leu 
            180                 185                 190         


Arg Thr Cys Trp Leu Ala Met Ala Asp Phe Arg Lys Thr Gly Asp Tyr 
        195                 200                 205             


Leu Trp Arg Lys Tyr Asn Gly Ala Ile Gln Val Val Met Asn Gln Asp 
    210                 215                 220                 


Gly Thr Gly Phe Thr Val Ala Asn Glu Arg Phe Lys Lys Pro Thr Lys 
225                 230                 235                 240 


Asn Asp Leu Val Tyr Phe Glu Asn Ser Pro Asp Tyr Cys Ile Arg Asp 
                245                 250                 255     


Arg Glu Ala Gly Ser Leu Gly Thr Ala Gly Arg Val Cys Asn Leu Thr 
            260                 265                 270         


Ser Arg Gly Met Asp Ser Cys Glu Val Met Cys Cys Gly Arg Gly Tyr 
        275                 280                 285             


Asp Thr Ser His Val Thr Arg Met Thr Lys Cys Gly Cys Lys Phe His 
    290                 295                 300                 


Trp Cys Cys Ala Val Arg Cys Gln Asp Cys Leu Glu Ala Leu Asp Val 
305                 310                 315                 320 


His Thr Cys Lys Ala Pro Lys Asn Ala Asp Trp Thr Thr Ala Thr 
                325                 330                 335 


<210> 84
<211> 333
<212> PRT
<213> Homo sapiens

<400> 84
Ser Trp Trp Tyr Ile Gly Ala Leu Gly Ala Arg Val Ile Cys Asp Asn 
1               5                   10                  15      


Ile Pro Gly Leu Val Ser Arg Gln Arg Gln Leu Cys Gln Arg Tyr Pro 
            20                  25                  30          


Asp Ile Met Arg Ser Val Gly Glu Gly Ala Arg Glu Trp Ile Arg Glu 
        35                  40                  45              


Cys Gln His Gln Phe Arg His His Arg Trp Asn Cys Thr Thr Leu Asp 
    50                  55                  60                  


Arg Asp His Thr Val Phe Gly Arg Val Met Leu Arg Ser Ser Arg Glu 
65                  70                  75                  80  


Ala Ala Phe Val Tyr Ala Ile Ser Ser Ala Gly Val Val His Ala Ile 
                85                  90                  95      


Thr Arg Ala Cys Ser Gln Gly Glu Leu Ser Val Cys Ser Cys Asp Pro 
            100                 105                 110         


Tyr Thr Arg Gly Arg His His Asp Gln Arg Gly Asp Phe Asp Trp Gly 
        115                 120                 125             


Gly Cys Ser Asp Asn Ile His Tyr Gly Val Arg Phe Ala Lys Ala Phe 
    130                 135                 140                 


Val Asp Ala Lys Glu Lys Arg Leu Lys Asp Ala Arg Ala Leu Met Asn 
145                 150                 155                 160 


Leu His Asn Asn Arg Cys Gly Arg Thr Ala Val Arg Arg Phe Leu Lys 
                165                 170                 175     


Leu Glu Cys Lys Cys His Gly Val Ser Gly Ser Cys Thr Leu Arg Thr 
            180                 185                 190         


Cys Trp Arg Ala Leu Ser Asp Phe Arg Arg Thr Gly Asp Tyr Leu Arg 
        195                 200                 205             


Arg Arg Tyr Asp Gly Ala Val Gln Val Met Ala Thr Gln Asp Gly Ala 
    210                 215                 220                 


Asn Phe Thr Ala Ala Arg Gln Gly Tyr Arg Arg Ala Thr Arg Thr Asp 
225                 230                 235                 240 


Leu Val Tyr Phe Asp Asn Ser Pro Asp Tyr Cys Val Leu Asp Lys Ala 
                245                 250                 255     


Ala Gly Ser Leu Gly Thr Ala Gly Arg Val Cys Ser Lys Thr Ser Lys 
            260                 265                 270         


Gly Thr Asp Gly Cys Glu Ile Met Cys Cys Gly Arg Gly Tyr Asp Thr 
        275                 280                 285             


Thr Arg Val Thr Arg Val Thr Gln Cys Glu Cys Lys Phe His Trp Cys 
    290                 295                 300                 


Cys Ala Val Arg Cys Lys Glu Cys Arg Asn Thr Val Asp Val His Thr 
305                 310                 315                 320 


Cys Lys Ala Pro Lys Lys Ala Glu Trp Leu Asp Gln Thr 
                325                 330             


<210> 85
<211> 334
<212> PRT
<213> Homo sapiens

<400> 85
Gly Tyr Pro Ile Trp Trp Ser Leu Ala Leu Gly Gln Gln Tyr Thr Ser 
1               5                   10                  15      


Leu Gly Ser Gln Pro Leu Leu Cys Gly Ser Ile Pro Gly Leu Val Pro 
            20                  25                  30          


Lys Gln Leu Arg Phe Cys Arg Asn Tyr Ile Glu Ile Met Pro Ser Val 
        35                  40                  45              


Ala Glu Gly Val Lys Leu Gly Ile Gln Glu Cys Gln His Gln Phe Arg 
    50                  55                  60                  


Gly Arg Arg Trp Asn Cys Thr Thr Ile Asp Asp Ser Leu Ala Ile Phe 
65                  70                  75                  80  


Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala 
                85                  90                  95      


Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu 
            100                 105                 110         


Gly Thr Ser Thr Ile Cys Gly Cys Asp Ser His His Lys Gly Pro Pro 
        115                 120                 125             


Gly Glu Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ala Asp Phe Gly 
    130                 135                 140                 


Val Leu Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp 
145                 150                 155                 160 


Ala Arg Ser Ala Met Asn Lys His Asn Asn Glu Ala Gly Arg Thr Thr 
                165                 170                 175     


Ile Leu Asp His Met His Leu Lys Cys Lys Cys His Gly Leu Ser Gly 
            180                 185                 190         


Ser Cys Glu Val Lys Thr Cys Trp Trp Ala Gln Pro Asp Phe Arg Ala 
        195                 200                 205             


Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val 
    210                 215                 220                 


Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Ala 
225                 230                 235                 240 


Lys Tyr Ser Leu Phe Lys Pro Pro Thr Glu Arg Asp Leu Val Tyr Tyr 
                245                 250                 255     


Glu Asn Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe 
            260                 265                 270         


Gly Thr Arg Asp Arg Thr Cys Asn Val Thr Ser His Gly Ile Asp Gly 
        275                 280                 285             


Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Thr Arg Thr Glu Lys 
    290                 295                 300                 


Arg Lys Glu Lys Cys His Cys Ile Phe His Trp Cys Cys Tyr Val Ser 
305                 310                 315                 320 


Cys Gln Glu Cys Ile Arg Ile Tyr Asp Val His Thr Cys Lys 
                325                 330                 


<210> 86
<211> 334
<212> PRT
<213> Homo sapiens

<400> 86
Ser Tyr Pro Ile Trp Trp Ser Leu Ala Val Gly Pro Gln Tyr Ser Ser 
1               5                   10                  15      


Leu Gly Ser Gln Pro Ile Leu Cys Ala Ser Ile Pro Gly Leu Val Pro 
            20                  25                  30          


Lys Gln Leu Arg Phe Cys Arg Asn Tyr Val Glu Ile Met Pro Ser Val 
        35                  40                  45              


Ala Glu Gly Ile Lys Ile Gly Ile Gln Glu Cys Gln His Gln Phe Arg 
    50                  55                  60                  


Gly Arg Arg Trp Asn Cys Thr Thr Val His Asp Ser Leu Ala Ile Phe 
65                  70                  75                  80  


Gly Pro Val Leu Asp Lys Ala Thr Arg Glu Ser Ala Phe Val His Ala 
                85                  90                  95      


Ile Ala Ser Ala Gly Val Ala Phe Ala Val Thr Arg Ser Cys Ala Glu 
            100                 105                 110         


Gly Thr Ala Ala Ile Cys Gly Cys Ser Ser Arg His Gln Gly Ser Pro 
        115                 120                 125             


Gly Lys Gly Trp Lys Trp Gly Gly Cys Ser Glu Asp Ile Glu Phe Gly 
    130                 135                 140                 


Gly Met Val Ser Arg Glu Phe Ala Asp Ala Arg Glu Asn Arg Pro Asp 
145                 150                 155                 160 


Ala Arg Ser Ala Met Asn Arg His Asn Asn Glu Ala Gly Arg Gln Ala 
                165                 170                 175     


Ile Ala Ser His Met His Leu Lys Cys Lys Cys His Gly Leu Ser Gly 
            180                 185                 190         


Ser Cys Glu Val Lys Thr Cys Trp Trp Ser Gln Pro Asp Phe Arg Ala 
        195                 200                 205             


Ile Gly Asp Phe Leu Lys Asp Lys Tyr Asp Ser Ala Ser Glu Met Val 
    210                 215                 220                 


Val Glu Lys His Arg Glu Ser Arg Gly Trp Val Glu Thr Leu Arg Pro 
225                 230                 235                 240 


Arg Tyr Thr Tyr Phe Lys Val Pro Thr Glu Arg Asp Leu Val Tyr Tyr 
                245                 250                 255     


Glu Ala Ser Pro Asn Phe Cys Glu Pro Asn Pro Glu Thr Gly Ser Phe 
            260                 265                 270         


Gly Thr Arg Asp Arg Thr Cys Asn Val Ser Ser His Gly Ile Asp Gly 
        275                 280                 285             


Cys Asp Leu Leu Cys Cys Gly Arg Gly His Asn Ala Arg Ala Glu Arg 
    290                 295                 300                 


Arg Arg Glu Lys Cys Arg Cys Val Phe His Trp Cys Cys Tyr Val Ser 
305                 310                 315                 320 


Cys Gln Glu Cys Thr Arg Val Tyr Asp Val His Thr Cys Lys 
                325                 330                 


<210> 87
<211> 329
<212> PRT
<213> Homo sapiens

<400> 87
Ser Asn Trp Leu Tyr Leu Ala Lys Leu Ser Ser Val Gly Ser Ile Ser 
1               5                   10                  15      


Glu Glu Glu Thr Cys Glu Lys Leu Lys Gly Leu Ile Gln Arg Gln Val 
            20                  25                  30          


Gln Met Cys Lys Arg Asn Leu Glu Val Met Asp Ser Val Arg Arg Gly 
        35                  40                  45              


Ala Gln Leu Ala Ile Glu Glu Cys Gln Tyr Gln Phe Arg Asn Arg Arg 
    50                  55                  60                  


Trp Asn Cys Ser Thr Leu Asp Ser Leu Pro Val Phe Gly Lys Val Val 
65                  70                  75                  80  


Thr Gln Gly Thr Arg Glu Ala Ala Phe Val Tyr Ala Ile Ser Ser Ala 
                85                  90                  95      


Gly Val Ala Phe Ala Val Thr Arg Ala Cys Ser Ser Gly Glu Leu Glu 
            100                 105                 110         


Lys Cys Gly Cys Asp Arg Thr Val His Gly Val Ser Pro Gln Gly Phe 
        115                 120                 125             


Gln Trp Ser Gly Cys Ser Asp Asn Ile Ala Tyr Gly Val Ala Phe Ser 
    130                 135                 140                 


Gln Ser Phe Val Asp Val Arg Glu Arg Ser Lys Gly Ala Ser Ser Ser 
145                 150                 155                 160 


Arg Ala Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ala Ile 
                165                 170                 175     


Leu Thr His Met Arg Val Glu Cys Lys Cys His Gly Val Ser Gly Ser 
            180                 185                 190         


Cys Glu Val Lys Thr Cys Trp Arg Ala Val Pro Pro Phe Arg Gln Val 
        195                 200                 205             


Gly His Ala Leu Lys Glu Lys Phe Asp Gly Ala Thr Glu Val Glu Pro 
    210                 215                 220                 


Arg Arg Val Gly Ser Ser Arg Ala Leu Val Pro Arg Asn Ala Gln Phe 
225                 230                 235                 240 


Lys Pro His Thr Asp Glu Asp Leu Val Tyr Leu Glu Pro Ser Pro Asp 
                245                 250                 255     


Phe Cys Glu Gln Asp Met Arg Ser Gly Val Leu Gly Thr Arg Gly Arg 
            260                 265                 270         


Thr Cys Asn Lys Thr Ser Lys Ala Ile Asp Gly Cys Glu Leu Leu Cys 
        275                 280                 285             


Cys Gly Arg Gly Phe His Thr Ala Gln Val Glu Leu Ala Glu Arg Cys 
    290                 295                 300                 


Ser Cys Lys Phe His Trp Cys Cys Phe Val Lys Cys Arg Gln Cys Gln 
305                 310                 315                 320 


Arg Leu Val Glu Leu His Thr Cys Arg 
                325                 


<210> 88
<211> 319
<212> PRT
<213> Homo sapiens

<400> 88
Ile Ile Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln 
1               5                   10                  15      


Gly Gln Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile 
            20                  25                  30          


Gly Glu Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg 
        35                  40                  45              


His Arg Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly 
    50                  55                  60                  


Arg Val Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val 
65                  70                  75                  80  


Ser Ala Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly 
                85                  90                  95      


Glu Leu Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu 
            100                 105                 110         


Pro Arg Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly 
        115                 120                 125             


Tyr Arg Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile 
    130                 135                 140                 


His Ala Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His 
145                 150                 155                 160 


Asn Asn Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala 
                165                 170                 175     


Cys Lys Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp 
            180                 185                 190         


Leu Gln Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys 
        195                 200                 205             


Tyr Asp Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val 
    210                 215                 220                 


Gln Val Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr 
225                 230                 235                 240 


Ile Asp Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser 
                245                 250                 255     


Leu Gly Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp 
            260                 265                 270         


Gly Cys Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr 
        275                 280                 285             


Val Gln Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val 
    290                 295                 300                 


Lys Cys Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
305                 310                 315                 


<210> 89
<211> 342
<212> PRT
<213> Homo sapiens

<400> 89
Gln Leu Leu Thr Asp Ala Asn Ser Trp Trp Ser Leu Ala Leu Asn Pro 
1               5                   10                  15      


Val Gln Arg Pro Glu Met Phe Ile Ile Gly Ala Gln Pro Val Cys Ser 
            20                  25                  30          


Gln Leu Pro Gly Leu Ser Pro Gly Gln Arg Lys Leu Cys Gln Leu Tyr 
        35                  40                  45              


Gln Glu His Met Ala Tyr Ile Gly Glu Gly Ala Lys Thr Gly Ile Lys 
    50                  55                  60                  


Glu Cys Gln His Gln Phe Arg Gln Arg Arg Trp Asn Cys Ser Thr Ala 
65                  70                  75                  80  


Asp Asn Ala Ser Val Phe Gly Arg Val Met Gln Ile Gly Ser Arg Glu 
                85                  90                  95      


Thr Ala Phe Thr His Ala Val Ser Ala Ala Gly Val Val Asn Ala Ile 
            100                 105                 110         


Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser Thr Cys Gly Cys Ser Arg 
        115                 120                 125             


Thr Ala Arg Pro Lys Asp Leu Pro Arg Asp Trp Leu Trp Gly Gly Cys 
    130                 135                 140                 


Gly Asp Asn Val Glu Tyr Gly Tyr Arg Phe Ala Lys Glu Phe Val Asp 
145                 150                 155                 160 


Ala Arg Glu Arg Glu Lys Asn Phe Ala Lys Gly Ser Glu Glu Gln Gly 
                165                 170                 175     


Arg Val Leu Met Asn Leu Gln Asn Asn Glu Ala Gly Arg Arg Ala Val 
            180                 185                 190         


Tyr Lys Met Ala Asp Val Ala Cys Lys Cys His Gly Val Ser Gly Ser 
        195                 200                 205             


Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu Ala Glu Phe Arg Lys Val 
    210                 215                 220                 


Gly Asp Arg Leu Lys Glu Lys Tyr Asp Ser Ala Ala Ala Met Arg Val 
225                 230                 235                 240 


Thr Arg Lys Gly Arg Leu Glu Leu Val Asn Ser Arg Phe Thr Gln Pro 
                245                 250                 255     


Thr Pro Glu Asp Leu Val Tyr Val Asp Pro Ser Pro Asp Tyr Cys Leu 
            260                 265                 270         


Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr Gln Gly Arg Leu Cys Asn 
        275                 280                 285             


Lys Thr Ser Glu Gly Met Asp Gly Cys Glu Leu Met Cys Cys Gly Arg 
    290                 295                 300                 


Gly Tyr Asn Gln Phe Lys Ser Val Gln Val Glu Arg Cys His Cys Lys 
305                 310                 315                 320 


Phe His Trp Cys Cys Phe Val Arg Cys Lys Lys Cys Thr Glu Ile Val 
                325                 330                 335     


Asp Gln Tyr Ile Cys Lys 
            340         


<210> 90
<211> 341
<212> PRT
<213> Homo sapiens

<400> 90
Leu Trp Trp Ala Val Gly Ser Pro Leu Val Met Asp Pro Thr Ser Ile 
1               5                   10                  15      


Cys Arg Lys Ala Arg Arg Leu Ala Gly Arg Gln Ala Glu Leu Cys Gln 
            20                  25                  30          


Ala Glu Pro Glu Val Val Ala Glu Leu Ala Arg Gly Ala Arg Leu Gly 
        35                  40                  45              


Val Arg Glu Cys Gln Phe Gln Phe Arg Phe Arg Arg Trp Asn Cys Ser 
    50                  55                  60                  


Ser His Ser Lys Ala Phe Gly Arg Ile Leu Gln Gln Asp Ile Arg Glu 
65                  70                  75                  80  


Thr Ala Phe Val Phe Ala Ile Thr Ala Ala Gly Ala Ser His Ala Val 
                85                  90                  95      


Thr Gln Ala Cys Ser Met Gly Glu Leu Leu Gln Cys Gly Cys Gln Ala 
            100                 105                 110         


Pro Arg Gly Arg Ala Pro Pro Arg Pro Ser Gly Leu Pro Gly Thr Pro 
        115                 120                 125             


Gly Pro Pro Gly Pro Ala Gly Ser Pro Glu Gly Ser Ala Ala Trp Glu 
    130                 135                 140                 


Trp Gly Gly Cys Gly Asp Asp Val Asp Phe Gly Asp Glu Lys Ser Arg 
145                 150                 155                 160 


Leu Phe Met Asp Ala Arg His Lys Arg Gly Arg Gly Asp Ile Arg Ala 
                165                 170                 175     


Leu Val Gln Leu His Asn Asn Glu Ala Gly Arg Leu Ala Val Arg Ser 
            180                 185                 190         


His Thr Arg Thr Glu Cys Lys Cys His Gly Leu Ser Gly Ser Cys Ala 
        195                 200                 205             


Leu Arg Thr Cys Trp Gln Lys Leu Pro Pro Phe Arg Glu Val Gly Ala 
    210                 215                 220                 


Arg Leu Leu Glu Arg Phe His Gly Ala Ser Arg Val Met Gly Thr Asn 
225                 230                 235                 240 


Asp Gly Lys Ala Leu Leu Pro Ala Val Arg Thr Leu Lys Pro Pro Gly 
                245                 250                 255     


Arg Ala Asp Leu Leu Tyr Ala Ala Asp Ser Pro Asp Phe Cys Ala Pro 
            260                 265                 270         


Asn Arg Arg Thr Gly Ser Pro Gly Thr Arg Gly Arg Ala Cys Asn Ser 
        275                 280                 285             


Ser Ala Pro Asp Leu Ser Gly Cys Asp Leu Leu Cys Cys Gly Arg Gly 
    290                 295                 300                 


His Arg Gln Glu Ser Val Gln Leu Glu Glu Asn Cys Leu Cys Arg Phe 
305                 310                 315                 320 


His Trp Cys Cys Val Val Gln Cys His Arg Cys Arg Val Arg Lys Glu 
                325                 330                 335     


Leu Ser Leu Cys Leu 
            340     


<210> 91
<211> 318
<212> PRT
<213> Homo sapiens

<400> 91
Leu Gly Ala Ser Ile Ile Cys Asn Lys Ile Pro Gly Leu Ala Pro Arg 
1               5                   10                  15      


Gln Arg Ala Ile Cys Gln Ser Arg Pro Asp Ala Ile Ile Val Ile Gly 
            20                  25                  30          


Glu Gly Ser Gln Met Gly Leu Asp Glu Cys Gln Phe Gln Phe Arg Asn 
        35                  40                  45              


Gly Arg Trp Asn Cys Ser Ala Leu Gly Glu Arg Thr Val Phe Gly Lys 
    50                  55                  60                  


Glu Leu Lys Val Gly Ser Arg Glu Ala Ala Phe Thr Tyr Ala Ile Ile 
65                  70                  75                  80  


Ala Ala Gly Val Ala His Ala Ile Thr Ala Ala Cys Thr Gln Gly Asn 
                85                  90                  95      


Leu Ser Asp Cys Gly Cys Asp Lys Glu Lys Gln Gly Gln Tyr His Arg 
            100                 105                 110         


Asp Glu Gly Trp Lys Trp Gly Gly Cys Ser Ala Asp Ile Arg Tyr Gly 
        115                 120                 125             


Ile Gly Phe Ala Lys Val Phe Val Asp Ala Arg Glu Ile Lys Gln Asn 
    130                 135                 140                 


Ala Arg Thr Leu Met Asn Leu His Asn Asn Glu Ala Gly Arg Lys Ile 
145                 150                 155                 160 


Leu Glu Glu Asn Met Lys Leu Glu Cys Lys Cys His Gly Val Ser Gly 
                165                 170                 175     


Ser Cys Thr Thr Lys Thr Cys Trp Thr Thr Leu Pro Gln Phe Arg Glu 
            180                 185                 190         


Leu Gly Tyr Val Leu Lys Asp Lys Tyr Asn Glu Ala Val His Val Glu 
        195                 200                 205             


Pro Val Arg Ala Ser Arg Asn Lys Arg Pro Thr Phe Leu Lys Ile Lys 
    210                 215                 220                 


Lys Pro Leu Ser Tyr Arg Lys Pro Met Asp Thr Asp Leu Val Tyr Ile 
225                 230                 235                 240 


Glu Lys Ser Pro Asn Tyr Cys Glu Glu Asp Pro Val Thr Gly Ser Val 
                245                 250                 255     


Gly Thr Gln Gly Arg Ala Cys Asn Lys Thr Ala Pro Gln Ala Ser Gly 
            260                 265                 270         


Cys Asp Leu Met Cys Cys Gly Arg Gly Tyr Asn Thr His Gln Tyr Ala 
        275                 280                 285             


Arg Val Trp Gln Cys Asn Cys Lys Phe His Trp Cys Cys Tyr Val Lys 
    290                 295                 300                 


Cys Asn Thr Cys Ser Glu Arg Thr Glu Met Tyr Thr Cys Lys 
305                 310                 315             


<210> 92
<211> 325
<212> PRT
<213> Homo sapiens

<400> 92
Ala Leu Ser Ser Val Val Ala Leu Gly Ala Asn Ile Ile Cys Asn Lys 
1               5                   10                  15      


Ile Pro Gly Leu Ala Pro Arg Gln Arg Ala Ile Cys Gln Ser Arg Pro 
            20                  25                  30          


Asp Ala Ile Ile Val Ile Gly Glu Gly Ala Gln Met Gly Ile Asn Glu 
        35                  40                  45              


Cys Gln Tyr Gln Phe Arg Phe Gly Arg Trp Asn Cys Ser Ala Leu Gly 
    50                  55                  60                  


Glu Lys Thr Val Phe Gly Gln Glu Leu Arg Val Gly Ser Arg Glu Ala 
65                  70                  75                  80  


Ala Phe Thr Tyr Ala Ile Thr Ala Ala Gly Val Ala His Ala Val Thr 
                85                  90                  95      


Ala Ala Cys Ser Gln Gly Asn Leu Ser Asn Cys Gly Cys Asp Arg Glu 
            100                 105                 110         


Lys Gln Gly Tyr Tyr Asn Gln Ala Glu Gly Trp Lys Trp Gly Gly Cys 
        115                 120                 125             


Ser Ala Asp Val Arg Tyr Gly Ile Asp Phe Ser Arg Arg Phe Val Asp 
    130                 135                 140                 


Ala Arg Glu Ile Lys Lys Asn Ala Arg Arg Leu Met Asn Leu His Asn 
145                 150                 155                 160 


Asn Glu Ala Gly Arg Lys Val Leu Glu Asp Arg Met Gln Leu Glu Cys 
                165                 170                 175     


Lys Cys His Gly Val Ser Gly Ser Cys Thr Thr Lys Thr Cys Trp Thr 
            180                 185                 190         


Thr Leu Pro Lys Phe Arg Glu Val Gly His Leu Leu Lys Glu Lys Tyr 
        195                 200                 205             


Asn Ala Ala Val Gln Val Glu Val Val Arg Ala Ser Arg Leu Arg Gln 
    210                 215                 220                 


Pro Thr Phe Leu Arg Ile Lys Gln Leu Arg Ser Tyr Gln Lys Pro Met 
225                 230                 235                 240 


Glu Thr Asp Leu Val Tyr Ile Glu Lys Ser Pro Asn Tyr Cys Glu Glu 
                245                 250                 255     


Asp Ala Ala Thr Gly Ser Val Gly Thr Gln Gly Arg Leu Cys Asn Arg 
            260                 265                 270         


Thr Ser Pro Gly Ala Asp Gly Cys Asp Thr Met Cys Cys Gly Arg Gly 
        275                 280                 285             


Tyr Asn Thr His Gln Tyr Thr Lys Val Trp Gln Cys Asn Cys Lys Phe 
    290                 295                 300                 


His Trp Cys Cys Phe Val Lys Cys Asn Thr Cys Ser Glu Arg Thr Glu 
305                 310                 315                 320 


Val Phe Thr Cys Lys 
                325 


<210> 93
<211> 327
<212> PRT
<213> Homo sapiens

<400> 93
Val Asn Asn Phe Leu Ile Thr Gly Pro Lys Ala Tyr Leu Thr Tyr Thr 
1               5                   10                  15      


Thr Ser Val Ala Leu Gly Ala Gln Ser Gly Ile Glu Glu Cys Lys Phe 
            20                  25                  30          


Gln Phe Ala Trp Glu Arg Trp Asn Cys Pro Glu Asn Ala Leu Gln Leu 
        35                  40                  45              


Ser Thr His Asn Arg Leu Arg Ser Ala Thr Arg Glu Thr Ser Phe Ile 
    50                  55                  60                  


His Ala Ile Ser Ser Ala Gly Val Met Tyr Ile Ile Thr Lys Asn Cys 
65                  70                  75                  80  


Ser Met Gly Asp Phe Glu Asn Cys Gly Cys Asp Gly Ser Asn Asn Gly 
                85                  90                  95      


Lys Thr Gly Gly His Gly Trp Ile Trp Gly Gly Cys Ser Asp Asn Val 
            100                 105                 110         


Glu Phe Gly Glu Arg Ile Ser Lys Leu Phe Val Asp Ser Leu Glu Lys 
        115                 120                 125             


Gly Lys Asp Ala Arg Ala Leu Met Asn Leu His Asn Asn Arg Ala Gly 
    130                 135                 140                 


Arg Leu Ala Val Arg Ala Thr Met Lys Arg Thr Cys Lys Cys His Gly 
145                 150                 155                 160 


Ile Ser Gly Ser Cys Ser Ile Gln Thr Cys Trp Leu Gln Leu Ala Glu 
                165                 170                 175     


Phe Arg Glu Met Gly Asp Tyr Leu Lys Ala Lys Tyr Asp Gln Ala Leu 
            180                 185                 190         


Lys Ile Glu Met Asp Lys Arg Gln Leu Arg Ala Gly Asn Ser Ala Glu 
        195                 200                 205             


Gly His Trp Val Pro Ala Glu Ala Phe Leu Pro Ser Ala Glu Ala Glu 
    210                 215                 220                 


Leu Ile Phe Leu Glu Glu Ser Pro Asp Tyr Cys Thr Cys Asn Ser Ser 
225                 230                 235                 240 


Leu Gly Ile Tyr Gly Thr Glu Gly Arg Glu Cys Leu Gln Asn Ser His 
                245                 250                 255     


Asn Thr Ser Arg Trp Glu Arg Arg Ser Cys Gly Arg Leu Cys Thr Glu 
            260                 265                 270         


Cys Gly Leu Gln Val Glu Glu Arg Lys Thr Glu Val Ile Ser Ser Cys 
        275                 280                 285             


Asn Cys Lys Phe Gln Trp Cys Cys Thr Val Lys Cys Asp Gln Cys Arg 
    290                 295                 300                 


His Val Val Ser Lys Tyr Tyr Cys Ala Arg Ser Pro Gly Ser Ala Gln 
305                 310                 315                 320 


Ser Leu Gly Lys Gly Ser Ala 
                325         


<210> 94
<211> 329
<212> PRT
<213> Homo sapiens

<400> 94
Trp Ser Val Asn Asn Phe Leu Met Thr Gly Pro Lys Ala Tyr Leu Ile 
1               5                   10                  15      


Tyr Ser Ser Ser Val Ala Ala Gly Ala Gln Ser Gly Ile Glu Glu Cys 
            20                  25                  30          


Lys Tyr Gln Phe Ala Trp Asp Arg Trp Asn Cys Pro Glu Arg Ala Leu 
        35                  40                  45              


Gln Leu Ser Ser His Gly Gly Leu Arg Ser Ala Asn Arg Glu Thr Ala 
    50                  55                  60                  


Phe Val His Ala Ile Ser Ser Ala Gly Val Met Tyr Thr Leu Thr Arg 
65                  70                  75                  80  


Asn Cys Ser Leu Gly Asp Phe Asp Asn Cys Gly Cys Asp Asp Ser Arg 
                85                  90                  95      


Asn Gly Gln Leu Gly Gly Gln Gly Trp Leu Trp Gly Gly Cys Ser Asp 
            100                 105                 110         


Asn Val Gly Phe Gly Glu Ala Ile Ser Lys Gln Phe Val Asp Ala Leu 
        115                 120                 125             


Glu Thr Gly Gln Asp Ala Arg Ala Ala Met Asn Leu His Asn Asn Glu 
    130                 135                 140                 


Ala Gly Arg Lys Ala Val Lys Gly Thr Met Lys Arg Thr Cys Lys Cys 
145                 150                 155                 160 


His Gly Val Ser Gly Ser Cys Thr Thr Gln Thr Cys Trp Leu Gln Leu 
                165                 170                 175     


Pro Glu Phe Arg Glu Val Gly Ala His Leu Lys Glu Lys Tyr His Ala 
            180                 185                 190         


Ala Leu Lys Val Asp Leu Leu Gln Gly Ala Gly Asn Ser Ala Ala Gly 
        195                 200                 205             


Arg Gly Ala Ile Ala Asp Thr Phe Arg Ser Ile Ser Thr Arg Glu Leu 
    210                 215                 220                 


Val His Leu Glu Asp Ser Pro Asp Tyr Cys Leu Glu Asn Lys Thr Leu 
225                 230                 235                 240 


Gly Leu Leu Gly Thr Glu Gly Arg Glu Cys Leu Arg Arg Gly Arg Ala 
                245                 250                 255     


Leu Gly Arg Trp Glu Arg Arg Ser Cys Arg Arg Leu Cys Gly Asp Cys 
            260                 265                 270         


Gly Leu Ala Val Glu Glu Arg Arg Ala Glu Thr Val Ser Ser Cys Asn 
        275                 280                 285             


Cys Lys Phe His Trp Cys Cys Ala Val Arg Cys Glu Gln Cys Arg Arg 
    290                 295                 300                 


Arg Val Thr Lys Tyr Phe Cys Ser Arg Ala Glu Arg Pro Arg Gly Gly 
305                 310                 315                 320 


Ala Ala His Lys Pro Gly Arg Lys Pro 
                325                 


<210> 95
<211> 336
<212> PRT
<213> Homo sapiens

<400> 95
Tyr Phe Gly Leu Thr Gly Ser Glu Pro Leu Thr Ile Leu Pro Leu Thr 
1               5                   10                  15      


Leu Glu Pro Glu Ala Ala Ala Gln Ala His Tyr Lys Ala Cys Asp Arg 
            20                  25                  30          


Leu Lys Leu Glu Arg Lys Gln Arg Arg Met Cys Arg Arg Asp Pro Gly 
        35                  40                  45              


Val Ala Glu Thr Leu Val Glu Ala Val Ser Met Ser Ala Leu Glu Cys 
    50                  55                  60                  


Gln Phe Gln Phe Arg Phe Glu Arg Trp Asn Cys Thr Leu Glu Gly Arg 
65                  70                  75                  80  


Tyr Arg Ala Ser Leu Leu Lys Arg Gly Phe Lys Glu Thr Ala Phe Leu 
                85                  90                  95      


Tyr Ala Ile Ser Ser Ala Gly Leu Thr His Ala Leu Ala Lys Ala Cys 
            100                 105                 110         


Ser Ala Gly Arg Met Glu Arg Cys Thr Cys Asp Glu Ala Pro Asp Leu 
        115                 120                 125             


Glu Asn Arg Glu Ala Trp Gln Trp Gly Gly Cys Gly Asp Asn Leu Lys 
    130                 135                 140                 


Tyr Ser Ser Lys Phe Val Lys Glu Phe Leu Gly Arg Arg Ser Ser Lys 
145                 150                 155                 160 


Asp Leu Arg Ala Arg Val Asp Phe His Asn Asn Leu Val Gly Val Lys 
                165                 170                 175     


Val Ile Lys Ala Gly Val Glu Thr Thr Cys Lys Cys His Gly Val Ser 
            180                 185                 190         


Gly Ser Cys Thr Val Arg Thr Cys Trp Arg Gln Leu Ala Pro Phe His 
        195                 200                 205             


Glu Val Gly Lys His Leu Lys His Lys Tyr Glu Thr Ala Leu Lys Val 
    210                 215                 220                 


Gly Ser Thr Thr Asn Glu Ala Ala Gly Glu Ala Gly Ala Ile Ser Pro 
225                 230                 235                 240 


Pro Arg Gly Arg Ala Ser Gly Ala Gly Gly Ser Asp Pro Leu Pro Arg 
                245                 250                 255     


Thr Pro Glu Leu Val His Leu Asp Asp Ser Pro Ser Phe Cys Leu Ala 
            260                 265                 270         


Gly Arg Phe Ser Pro Gly Thr Ala Gly Arg Arg Cys His Arg Glu Lys 
        275                 280                 285             


Asn Cys Glu Ser Ile Cys Cys Gly Arg Gly His Asn Thr Gln Ser Arg 
    290                 295                 300                 


Val Val Thr Arg Pro Cys Gln Cys Gln Val Arg Trp Cys Cys Tyr Val 
305                 310                 315                 320 


Glu Cys Arg Gln Cys Thr Gln Arg Glu Glu Val Tyr Thr Cys Lys Gly 
                325                 330                 335     


<210> 96
<211> 335
<212> PRT
<213> Homo sapiens

<400> 96
Ser Tyr Phe Gly Leu Thr Gly Arg Glu Val Leu Thr Pro Phe Pro Gly 
1               5                   10                  15      


Leu Gly Thr Ala Ala Ala Pro Ala Gln Gly Gly Ala His Leu Lys Gln 
            20                  25                  30          


Cys Asp Leu Leu Lys Leu Ser Arg Arg Gln Lys Gln Leu Cys Arg Arg 
        35                  40                  45              


Glu Pro Gly Leu Ala Glu Thr Leu Arg Asp Ala Ala His Leu Gly Leu 
    50                  55                  60                  


Leu Glu Cys Gln Phe Gln Phe Arg His Glu Arg Trp Asn Cys Ser Leu 
65                  70                  75                  80  


Glu Gly Arg Met Gly Leu Leu Lys Arg Gly Phe Lys Glu Thr Ala Phe 
                85                  90                  95      


Leu Tyr Ala Val Ser Ser Ala Ala Leu Thr His Thr Leu Ala Arg Ala 
            100                 105                 110         


Cys Ser Ala Gly Arg Met Glu Arg Cys Thr Cys Asp Asp Ser Pro Gly 
        115                 120                 125             


Leu Glu Ser Arg Gln Ala Trp Gln Trp Gly Val Cys Gly Asp Asn Leu 
    130                 135                 140                 


Lys Tyr Ser Thr Lys Phe Leu Ser Asn Phe Leu Gly Ser Lys Arg Gly 
145                 150                 155                 160 


Asn Lys Asp Leu Arg Ala Arg Ala Asp Ala His Asn Thr His Val Gly 
                165                 170                 175     


Ile Lys Ala Val Lys Ser Gly Leu Arg Thr Thr Cys Lys Cys His Gly 
            180                 185                 190         


Val Ser Gly Ser Cys Ala Val Arg Thr Cys Trp Lys Gln Leu Ser Pro 
        195                 200                 205             


Phe Arg Glu Thr Gly Gln Val Leu Lys Leu Arg Tyr Asp Ser Ala Val 
    210                 215                 220                 


Lys Val Ser Ser Ala Thr Asn Glu Ala Leu Gly Arg Leu Glu Leu Trp 
225                 230                 235                 240 


Ala Pro Ala Arg Gln Gly Ser Leu Thr Lys Gly Leu Ala Pro Arg Ser 
                245                 250                 255     


Gly Asp Leu Val Tyr Met Glu Asp Ser Pro Ser Phe Cys Arg Pro Ser 
            260                 265                 270         


Lys Tyr Ser Pro Gly Thr Ala Gly Arg Val Cys Ser Arg Glu Ala Ser 
        275                 280                 285             


Cys Ser Ser Leu Cys Cys Gly Arg Gly Tyr Asp Thr Gln Ser Arg Leu 
    290                 295                 300                 


Val Ala Phe Ser Cys His Cys Gln Val Gln Trp Cys Cys Tyr Val Glu 
305                 310                 315                 320 


Cys Gln Gln Cys Val Gln Glu Glu Leu Val Tyr Thr Cys Lys His 
                325                 330                 335 


<210> 97
<211> 382
<212> PRT
<213> Homo sapiens

<400> 97
Met Pro Arg Ser Ala Pro Asn Asp Ile Leu Asp Leu Arg Leu Pro Pro 
1               5                   10                  15      


Glu Pro Val Leu Asn Ala Asn Thr Val Cys Leu Thr Leu Pro Gly Leu 
            20                  25                  30          


Ser Arg Arg Gln Met Glu Val Cys Val Arg His Pro Asp Val Ala Ala 
        35                  40                  45              


Ser Ala Ile Gln Gly Ile Gln Ile Ala Ile His Glu Cys Gln His Gln 
    50                  55                  60                  


Phe Arg Asp Gln Arg Trp Asn Cys Ser Ser Leu Glu Thr Arg Asn Lys 
65                  70                  75                  80  


Ile Pro Tyr Glu Ser Pro Ile Phe Ser Arg Gly Phe Arg Glu Ser Ala 
                85                  90                  95      


Phe Ala Tyr Ala Ile Ala Ala Ala Gly Val Val His Ala Val Ser Asn 
            100                 105                 110         


Ala Cys Ala Leu Gly Lys Leu Lys Ala Cys Gly Cys Asp Ala Ser Arg 
        115                 120                 125             


Arg Gly Asp Glu Glu Ala Phe Arg Arg Lys Leu His Arg Leu Gln Leu 
    130                 135                 140                 


Asp Ala Leu Gln Arg Gly Lys Gly Leu Ser His Gly Val Pro Glu His 
145                 150                 155                 160 


Pro Ala Leu Pro Thr Ala Ser Pro Gly Leu Gln Asp Ser Trp Glu Trp 
                165                 170                 175     


Gly Gly Cys Ser Pro Asp Met Gly Phe Gly Glu Arg Phe Ser Lys Asp 
            180                 185                 190         


Phe Leu Asp Ser Arg Glu Pro His Arg Asp Ile His Ala Arg Met Arg 
        195                 200                 205             


Leu His Asn Asn Arg Val Gly Arg Gln Ala Val Met Glu Asn Met Arg 
    210                 215                 220                 


Arg Lys Cys Lys Cys His Gly Thr Ser Gly Ser Cys Gln Leu Lys Thr 
225                 230                 235                 240 


Cys Trp Gln Val Thr Pro Glu Phe Arg Thr Val Gly Ala Leu Leu Arg 
                245                 250                 255     


Ser Arg Phe His Arg Ala Thr Leu Ile Arg Pro His Asn Arg Asn Gly 
            260                 265                 270         


Gly Gln Leu Glu Pro Gly Pro Ala Gly Ala Pro Ser Pro Ala Pro Gly 
        275                 280                 285             


Ala Pro Gly Pro Arg Arg Arg Ala Ser Pro Ala Asp Leu Val Tyr Phe 
    290                 295                 300                 


Glu Lys Ser Pro Asp Phe Cys Glu Arg Glu Pro Arg Leu Asp Ser Ala 
305                 310                 315                 320 


Gly Thr Val Gly Arg Leu Cys Asn Lys Ser Ser Ala Gly Ser Asp Gly 
                325                 330                 335     


Cys Gly Ser Met Cys Cys Gly Arg Gly His Asn Ile Leu Arg Gln Thr 
            340                 345                 350         


Arg Ser Glu Arg Cys His Cys Arg Phe His Trp Cys Cys Phe Val Val 
        355                 360                 365             


Cys Glu Glu Cys Arg Ile Thr Glu Trp Val Ser Val Cys Lys 
    370                 375                 380         


<210> 98
<211> 361
<212> PRT
<213> Homo sapiens

<400> 98
Asn Glu Ile Leu Gly Leu Lys Leu Pro Gly Glu Pro Pro Leu Thr Ala 
1               5                   10                  15      


Asn Thr Val Cys Leu Thr Leu Ser Gly Leu Ser Lys Arg Gln Leu Gly 
            20                  25                  30          


Leu Cys Leu Arg Asn Pro Asp Val Thr Ala Ser Ala Leu Gln Gly Leu 
        35                  40                  45              


His Ile Ala Val His Glu Cys Gln His Gln Leu Arg Asp Gln Arg Trp 
    50                  55                  60                  


Asn Cys Ser Ala Leu Glu Gly Gly Gly Arg Leu Pro His His Ser Ala 
65                  70                  75                  80  


Ile Leu Lys Arg Gly Phe Arg Glu Ser Ala Phe Ser Phe Ser Met Leu 
                85                  90                  95      


Ala Ala Gly Val Met His Ala Val Ala Thr Ala Cys Ser Leu Gly Lys 
            100                 105                 110         


Leu Val Ser Cys Gly Cys Gly Trp Lys Gly Ser Gly Glu Gln Asp Arg 
        115                 120                 125             


Leu Arg Ala Lys Leu Leu Gln Leu Gln Ala Leu Ser Arg Gly Lys Ser 
    130                 135                 140                 


Phe Pro His Ser Leu Pro Ser Pro Gly Pro Gly Ser Ser Pro Ser Pro 
145                 150                 155                 160 


Gly Pro Gln Asp Thr Trp Glu Trp Gly Gly Cys Asn His Asp Met Asp 
                165                 170                 175     


Phe Gly Glu Lys Phe Ser Arg Asp Phe Leu Asp Ser Arg Glu Ala Pro 
            180                 185                 190         


Arg Asp Ile Gln Ala Arg Met Arg Ile His Asn Asn Arg Val Gly Arg 
        195                 200                 205             


Gln Val Val Thr Glu Asn Leu Lys Arg Lys Cys Lys Cys His Gly Thr 
    210                 215                 220                 


Ser Gly Ser Cys Gln Phe Lys Thr Cys Trp Arg Ala Ala Pro Glu Phe 
225                 230                 235                 240 


Arg Ala Val Gly Ala Ala Leu Arg Glu Arg Leu Gly Arg Ala Ile Phe 
                245                 250                 255     


Ile Asp Thr His Asn Arg Asn Ser Gly Ala Phe Gln Pro Arg Leu Arg 
            260                 265                 270         


Pro Arg Arg Leu Ser Gly Glu Leu Val Tyr Phe Glu Lys Ser Pro Asp 
        275                 280                 285             


Phe Cys Glu Arg Asp Pro Thr Met Gly Ser Pro Gly Thr Arg Gly Arg 
    290                 295                 300                 


Ala Cys Asn Lys Thr Ser Arg Leu Leu Asp Gly Cys Gly Ser Leu Cys 
305                 310                 315                 320 


Cys Gly Arg Gly His Asn Val Leu Arg Gln Thr Arg Val Glu Arg Cys 
                325                 330                 335     


His Cys Arg Phe His Trp Cys Cys Tyr Val Leu Cys Asp Glu Cys Lys 
            340                 345                 350         


Val Thr Glu Trp Val Asn Val Cys Lys 
        355                 360     


<210> 99
<211> 330
<212> PRT
<213> Homo sapiens

<400> 99
Ile Lys Trp Leu Ala Leu Ser Lys Thr Pro Ser Ala Leu Ala Leu Asn 
1               5                   10                  15      


Gln Thr Gln His Cys Lys Gln Leu Glu Gly Leu Val Ser Ala Gln Val 
            20                  25                  30          


Gln Leu Cys Arg Ser Asn Leu Glu Leu Met His Thr Val Val His Ala 
        35                  40                  45              


Ala Arg Glu Val Met Lys Ala Cys Arg Arg Ala Phe Ala Asp Met Arg 
    50                  55                  60                  


Trp Asn Cys Ser Ser Ile Glu Leu Ala Pro Asn Tyr Leu Leu Asp Leu 
65                  70                  75                  80  


Glu Arg Gly Thr Arg Glu Ser Ala Phe Val Tyr Ala Leu Ser Ala Ala 
                85                  90                  95      


Ala Ile Ser His Ala Ile Ala Arg Ala Cys Thr Ser Gly Asp Leu Pro 
            100                 105                 110         


Gly Cys Ser Cys Gly Pro Val Pro Gly Glu Pro Pro Gly Pro Gly Asn 
        115                 120                 125             


Arg Trp Gly Gly Cys Ala Asp Asn Leu Ser Tyr Gly Leu Leu Met Gly 
    130                 135                 140                 


Ala Lys Phe Ser Asp Ala Pro Met Lys Val Lys Lys Thr Gly Ser Gln 
145                 150                 155                 160 


Ala Asn Lys Leu Met Arg Leu His Asn Ser Glu Val Gly Arg Gln Ala 
                165                 170                 175     


Leu Arg Ala Ser Leu Glu Met Lys Cys Lys Cys His Gly Val Ser Gly 
            180                 185                 190         


Ser Cys Ser Ile Arg Thr Cys Trp Lys Gly Leu Gln Glu Leu Gln Asp 
        195                 200                 205             


Val Ala Ala Asp Leu Lys Thr Arg Tyr Leu Ser Ala Thr Lys Val Val 
    210                 215                 220                 


His Arg Pro Met Gly Thr Arg Lys His Leu Val Pro Lys Asp Leu Asp 
225                 230                 235                 240 


Ile Arg Pro Val Lys Asp Ser Glu Leu Val Tyr Leu Gln Ser Ser Pro 
                245                 250                 255     


Asp Phe Cys Met Lys Asn Glu Lys Val Gly Ser His Gly Thr Gln Asp 
            260                 265                 270         


Arg Gln Cys Asn Lys Thr Ser Asn Gly Ser Asp Ser Cys Asp Leu Met 
        275                 280                 285             


Cys Cys Gly Arg Gly Tyr Asn Pro Tyr Thr Asp Arg Val Val Glu Arg 
    290                 295                 300                 


Cys His Cys Lys Tyr His Trp Cys Cys Tyr Val Thr Cys Arg Arg Cys 
305                 310                 315                 320 


Glu Arg Thr Val Glu Arg Tyr Val Cys Lys 
                325                 330 


<210> 100
<211> 336
<212> PRT
<213> Homo sapiens

<400> 100
Asn Trp Met Trp Leu Gly Ile Ala Ser Phe Gly Val Pro Glu Lys Leu 
1               5                   10                  15      


Gly Cys Ala Asn Leu Pro Leu Asn Ser Arg Gln Lys Glu Leu Cys Lys 
            20                  25                  30          


Arg Lys Pro Tyr Leu Leu Pro Ser Ile Arg Glu Gly Ala Arg Leu Gly 
        35                  40                  45              


Ile Gln Glu Cys Gly Ser Gln Phe Arg His Glu Arg Trp Asn Cys Met 
    50                  55                  60                  


Ile Thr Ala Ala Ala Thr Thr Ala Pro Met Gly Ala Ser Pro Leu Phe 
65                  70                  75                  80  


Gly Tyr Glu Leu Ser Ser Gly Thr Lys Glu Thr Ala Phe Ile Tyr Ala 
                85                  90                  95      


Val Met Ala Ala Gly Leu Val His Ser Val Thr Arg Ser Cys Ser Ala 
            100                 105                 110         


Gly Asn Met Thr Glu Cys Ser Cys Asp Thr Thr Leu Gln Asn Gly Gly 
        115                 120                 125             


Ser Ala Ser Glu Gly Trp His Trp Gly Gly Cys Ser Asp Asp Val Gln 
    130                 135                 140                 


Tyr Gly Met Trp Phe Ser Arg Lys Phe Leu Asp Phe Pro Ile Gly Asn 
145                 150                 155                 160 


Thr Thr Gly Lys Glu Asn Lys Val Leu Leu Ala Met Asn Leu His Asn 
                165                 170                 175     


Asn Glu Ala Gly Arg Gln Ala Val Ala Lys Leu Met Ser Val Asp Cys 
            180                 185                 190         


Arg Cys His Gly Val Ser Gly Ser Cys Ala Val Lys Thr Cys Trp Lys 
        195                 200                 205             


Thr Met Ser Ser Phe Glu Lys Ile Gly His Leu Leu Lys Asp Lys Tyr 
    210                 215                 220                 


Glu Asn Ser Ile Gln Ile Ser Asp Lys Thr Lys Arg Lys Met Arg Arg 
225                 230                 235                 240 


Arg Glu Lys Asp Gln Arg Lys Ile Pro Ile His Lys Asp Asp Leu Leu 
                245                 250                 255     


Tyr Val Asn Lys Ser Pro Asn Tyr Cys Val Glu Asp Lys Lys Leu Gly 
            260                 265                 270         


Ile Pro Gly Thr Gln Gly Arg Glu Cys Asn Arg Thr Ser Glu Gly Ala 
        275                 280                 285             


Asp Gly Cys Asn Leu Leu Cys Cys Gly Arg Gly Tyr Asn Thr His Val 
    290                 295                 300                 


Val Arg His Val Glu Arg Cys Glu Cys Lys Phe Ile Trp Cys Cys Tyr 
305                 310                 315                 320 


Val Arg Cys Arg Arg Cys Glu Ser Met Thr Asp Val His Thr Cys Lys 
                325                 330                 335     


<210> 101
<211> 65
<212> PRT
<213> Homo sapiens

<400> 101
Ser His Leu Val Lys Cys Ala Glu Lys Glu Lys Thr Phe Cys Val Asn 
1               5                   10                  15      


Gly Gly Glu Cys Phe Met Val Lys Asp Leu Ser Asn Pro Ser Arg Tyr 
            20                  25                  30          


Leu Cys Lys Cys Pro Asn Glu Phe Thr Gly Asp Arg Cys Gln Asn Tyr 
        35                  40                  45              


Val Met Ala Ser Phe Tyr Lys His Leu Gly Ile Glu Phe Met Glu Ala 
    50                  55                  60                  


Glu 
65  


<210> 102

<400> 102
000


<210> 103

<400> 103
000


<210> 104

<400> 104
000


<210> 105

<400> 105
000


<210> 106

<400> 106
000


<210> 107

<400> 107
000


<210> 108

<400> 108
000


<210> 109

<400> 109
000


<210> 110

<400> 110
000


<210> 111

<400> 111
000


<210> 112

<400> 112
000


<210> 113

<400> 113
000


<210> 114

<400> 114
000


<210> 115

<400> 115
000


<210> 116

<400> 116
000


<210> 117

<400> 117
000


<210> 118

<400> 118
000


<210> 119

<400> 119
000


<210> 120

<400> 120
000


<210> 121

<400> 121
000


<210> 122

<400> 122
000


<210> 123

<400> 123
000


<210> 124

<400> 124
000


<210> 125

<400> 125
000


<210> 126

<400> 126
000


<210> 127

<400> 127
000


<210> 128

<400> 128
000


<210> 129

<400> 129
000


<210> 130

<400> 130
000


<210> 131

<400> 131
000


<210> 132

<400> 132
000


<210> 133

<400> 133
000


<210> 134

<400> 134
000


<210> 135

<400> 135
000


<210> 136

<400> 136
000


<210> 137

<400> 137
000


<210> 138

<400> 138
000


<210> 139

<400> 139
000


<210> 140

<400> 140
000


<210> 141

<400> 141
000


<210> 142

<400> 142
000


<210> 143

<400> 143
000


<210> 144

<400> 144
000


<210> 145

<400> 145
000


<210> 146

<400> 146
000


<210> 147

<400> 147
000


<210> 148

<400> 148
000


<210> 149

<400> 149
000


<210> 150

<400> 150
000


<210> 151

<400> 151
000


<210> 152
<211> 50
<212> PRT
<213> Homo sapiens

<400> 152
Val Val Ser His Phe Asn Asp Cys Pro Asp Ser His Thr Gln Phe Cys 
1               5                   10                  15      


Phe His Gly Thr Cys Arg Phe Leu Val Gln Glu Asp Lys Pro Ala Cys 
            20                  25                  30          


Val Cys His Ser Gly Tyr Val Gly Ala Arg Cys Glu His Ala Asp Leu 
        35                  40                  45              


Leu Ala 
    50  


<210> 153

<400> 153
000


<210> 154

<400> 154
000


<210> 155

<400> 155
000


<210> 156

<400> 156
000


<210> 157

<400> 157
000


<210> 158

<400> 158
000


<210> 159

<400> 159
000


<210> 160

<400> 160
000


<210> 161

<400> 161
000


<210> 162

<400> 162
000


<210> 163

<400> 163
000


<210> 164

<400> 164
000


<210> 165

<400> 165
000


<210> 166

<400> 166
000


<210> 167

<400> 167
000


<210> 168
<211> 1286
<212> PRT
<213> Homo sapiens

<400> 168
Ile Pro Val Pro Gln Ser Lys Pro Leu Glu Arg His Val Glu Lys Ser 
1               5                   10                  15      


Met Asn Leu His Leu Leu Ala Arg Ser Asn Val Ser Val Gln Asp Glu 
            20                  25                  30          


Leu Asn Ala Ser Gly Thr Ile Lys Glu Ser Gly Val Leu Val His Glu 
        35                  40                  45              


Gly Asp Arg Gly Arg Gln Glu Asn Thr Gln Asp Gly His Lys Gly Glu 
    50                  55                  60                  


Gly Asn Gly Ser Lys Trp Ala Glu Val Gly Gly Lys Ser Phe Ser Thr 
65                  70                  75                  80  


Tyr Ser Thr Leu Ala Asn Glu Glu Gly Asn Ile Glu Gly Trp Asn Gly 
                85                  90                  95      


Asp Thr Gly Lys Ala Glu Thr Tyr Gly His Asp Gly Ile His Gly Lys 
            100                 105                 110         


Glu Glu Asn Ile Thr Ala Asn Gly Ile Gln Gly Gln Val Ser Ile Ile 
        115                 120                 125             


Asp Asn Ala Gly Ala Thr Asn Arg Ser Asn Thr Asn Gly Asn Thr Asp 
    130                 135                 140                 


Lys Asn Thr Gln Asn Gly Asp Val Gly Asp Ala Gly His Asn Glu Asp 
145                 150                 155                 160 


Val Ala Val Val Gln Glu Asp Gly Pro Gln Val Ala Gly Ser Asn Asn 
                165                 170                 175     


Ser Thr Asp Asn Glu Asp Glu Ile Ile Glu Asn Ser Cys Arg Asn Glu 
            180                 185                 190         


Gly Asn Thr Ser Glu Ile Thr Pro Gln Ile Asn Ser Lys Arg Asn Gly 
        195                 200                 205             


Thr Lys Glu Ala Glu Val Thr Pro Gly Thr Gly Glu Asp Ala Gly Leu 
    210                 215                 220                 


Asp Asn Ser Asp Gly Ser Pro Ser Gly Asn Gly Ala Asp Glu Asp Glu 
225                 230                 235                 240 


Asp Glu Gly Ser Gly Asp Asp Glu Asp Glu Glu Ala Gly Asn Gly Lys 
                245                 250                 255     


Asp Ser Ser Asn Asn Ser Lys Gly Gln Glu Gly Gln Asp His Gly Lys 
            260                 265                 270         


Glu Asp Asp His Asp Ser Ser Ile Gly Gln Asn Ser Asp Ser Lys Glu 
        275                 280                 285             


Tyr Tyr Asp Pro Glu Gly Lys Glu Asp Pro His Asn Glu Val Asp Gly 
    290                 295                 300                 


Asp Lys Thr Ser Lys Ser Glu Glu Asn Ser Ala Gly Ile Pro Glu Asp 
305                 310                 315                 320 


Asn Gly Ser Gln Arg Ile Glu Asp Thr Gln Lys Leu Asn His Arg Glu 
                325                 330                 335     


Ser Lys Arg Val Glu Asn Arg Ile Thr Lys Glu Ser Glu Thr His Ala 
            340                 345                 350         


Val Gly Lys Ser Gln Asp Lys Gly Ile Glu Ile Lys Gly Pro Ser Ser 
        355                 360                 365             


Gly Asn Arg Asn Ile Thr Lys Glu Val Gly Lys Gly Asn Glu Gly Lys 
    370                 375                 380                 


Glu Asp Lys Gly Gln His Gly Met Ile Leu Gly Lys Gly Asn Val Lys 
385                 390                 395                 400 


Thr Gln Gly Glu Val Val Asn Ile Glu Gly Pro Gly Gln Lys Ser Glu 
                405                 410                 415     


Pro Gly Asn Lys Val Gly His Ser Asn Thr Gly Ser Asp Ser Asn Ser 
            420                 425                 430         


Asp Gly Tyr Asp Ser Tyr Asp Phe Asp Asp Lys Ser Met Gln Gly Asp 
        435                 440                 445             


Asp Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn Ser 
    450                 455                 460                 


Glu Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn Ser 
465                 470                 475                 480 


Asp Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala Glu 
                485                 490                 495     


Asp Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser Asn 
            500                 505                 510         


Gly Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser Gly 
        515                 520                 525             


Lys Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn 
    530                 535                 540                 


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Asn 
545                 550                 555                 560 


Ser Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser 
                565                 570                 575     


Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser 
            580                 585                 590         


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Lys 
        595                 600                 605             


Ser Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser Lys 
    610                 615                 620                 


Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser Asp 
625                 630                 635                 640 


Ser Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser 
                645                 650                 655     


Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser Ser 
            660                 665                 670         


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Glu Ser Ser Asp 
        675                 680                 685             


Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
    690                 695                 700                 


Asn Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
705                 710                 715                 720 


Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn 
                725                 730                 735     


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
            740                 745                 750         


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser 
        755                 760                 765             


Asp Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asn 
    770                 775                 780                 


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
785                 790                 795                 800 


Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp 
                805                 810                 815     


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
            820                 825                 830         


Ser Asp Gly Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser Asn 
        835                 840                 845             


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
    850                 855                 860                 


Ser Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp Ser Ser 
865                 870                 875                 880 


Asp Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser 
                885                 890                 895     


Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu Ser Ser 
            900                 905                 910         


Asn Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp 
        915                 920                 925             


Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser 
    930                 935                 940                 


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp 
945                 950                 955                 960 


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
                965                 970                 975     


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
            980                 985                 990         


Asp Ser Ser Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asn 
        995                 1000                 1005             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1010                 1015                 1020             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1025                 1030                 1035             


Ser Ser  Asn Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1040                 1045                 1050             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Glu 
    1055                 1060                 1065             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1070                 1075                 1080             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1085                 1090                 1095             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asn Ser Ser Asp  Ser Ser Asp 
    1100                 1105                 1110             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asn  Ser Ser Asp 
    1115                 1120                 1125             


Ser Ser  Asp Ser Ser Glu Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1130                 1135                 1140             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1145                 1150                 1155             


Ser Ser  Asp Ser Ser Asn Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1160                 1165                 1170             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1175                 1180                 1185             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asp 
    1190                 1195                 1200             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Asn Glu 
    1205                 1210                 1215             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Ser Asn 
    1220                 1225                 1230             


Ser Ser  Asp Ser Ser Asp Ser  Ser Asp Ser Ser Asp  Ser Thr Ser 
    1235                 1240                 1245             


Asp Ser  Asn Asp Glu Ser Asp  Ser Gln Ser Lys Ser  Gly Asn Gly 
    1250                 1255                 1260             


Asn Asn  Asn Gly Ser Asp Ser  Asp Ser Asp Ser Glu  Gly Ser Asp 
    1265                 1270                 1275             


Ser Asn  His Ser Thr Ser Asp  Asp 
    1280                 1285     


<210> 169

<400> 169
000


<210> 170

<400> 170
000


<210> 171

<400> 171
000


<210> 172

<400> 172
000


<210> 173

<400> 173
000


<210> 174

<400> 174
000


<210> 175

<400> 175
000


<210> 176
<211> 247
<212> PRT
<213> Homo sapiens

<400> 176
Ile Tyr Gly Gly Phe Lys Ser Thr Ala Gly Lys His Pro Trp Gln Ala 
1               5                   10                  15      


Ser Leu Gln Ser Ser Leu Pro Leu Thr Ile Ser Met Pro Gln Gly His 
            20                  25                  30          


Phe Cys Gly Gly Ala Leu Ile His Pro Cys Trp Val Leu Thr Ala Ala 
        35                  40                  45              


His Cys Thr Asp Ile Lys Thr Arg His Leu Lys Val Val Leu Gly Asp 
    50                  55                  60                  


Gln Asp Leu Lys Lys Glu Glu Phe His Glu Gln Ser Phe Arg Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Ser His Tyr Asn Glu Arg Asp Glu Ile Pro His 
                85                  90                  95      


Asn Asp Ile Ala Leu Leu Lys Leu Lys Pro Val Asp Gly His Cys Ala 
            100                 105                 110         


Leu Glu Ser Lys Tyr Val Lys Thr Val Cys Leu Pro Asp Gly Ser Phe 
        115                 120                 125             


Pro Ser Gly Ser Glu Cys His Ile Ser Gly Trp Gly Val Thr Glu Thr 
    130                 135                 140                 


Gly Lys Gly Ser Arg Gln Leu Leu Asp Ala Lys Val Lys Leu Ile Ala 
145                 150                 155                 160 


Asn Thr Leu Cys Asn Ser Arg Gln Leu Tyr Asp His Met Ile Asp Asp 
                165                 170                 175     


Ser Met Ile Cys Ala Gly Asn Leu Gln Lys Pro Gly Gln Asp Thr Cys 
            180                 185                 190         


Gln Gly Asp Ser Gly Gly Pro Leu Thr Cys Glu Lys Asp Gly Thr Tyr 
        195                 200                 205             


Tyr Val Tyr Gly Ile Val Ser Trp Gly Leu Glu Cys Gly Lys Arg Pro 
    210                 215                 220                 


Gly Val Tyr Thr Gln Val Thr Lys Phe Leu Asn Trp Ile Lys Ala Thr 
225                 230                 235                 240 


Ile Lys Ser Glu Ser Gly Phe 
                245         


<210> 177

<400> 177
000


<210> 178

<400> 178
000


<210> 179

<400> 179
000


<210> 180

<400> 180
000


<210> 181

<400> 181
000


<210> 182

<400> 182
000


<210> 183

<400> 183
000


<210> 184

<400> 184
000


<210> 185

<400> 185
000


<210> 186

<400> 186
000


<210> 187

<400> 187
000


<210> 188

<400> 188
000


<210> 189

<400> 189
000


<210> 190

<400> 190
000


<210> 191

<400> 191
000


<210> 192

<400> 192
000


<210> 193

<400> 193
000


<210> 194

<400> 194
000


<210> 195

<400> 195
000


<210> 196

<400> 196
000


<210> 197

<400> 197
000


<210> 198

<400> 198
000


<210> 199

<400> 199
000


<210> 200

<400> 200
000


<210> 201

<400> 201
000


<210> 202

<400> 202
000


<210> 203

<400> 203
000


<210> 204

<400> 204
000


<210> 205

<400> 205
000


<210> 206

<400> 206
000


<210> 207

<400> 207
000


<210> 208

<400> 208
000


<210> 209

<400> 209
000


<210> 210

<400> 210
000


<210> 211

<400> 211
000


<210> 212

<400> 212
000


<210> 213

<400> 213
000


<210> 214

<400> 214
000


<210> 215

<400> 215
000


<210> 216

<400> 216
000


<210> 217

<400> 217
000


<210> 218

<400> 218
000


<210> 219

<400> 219
000


<210> 220

<400> 220
000


<210> 221

<400> 221
000


<210> 222

<400> 222
000


<210> 223

<400> 223
000


<210> 224

<400> 224
000


<210> 225

<400> 225
000


<210> 226

<400> 226
000


<210> 227

<400> 227
000


<210> 228

<400> 228
000


<210> 229

<400> 229
000


<210> 230

<400> 230
000


<210> 231

<400> 231
000


<210> 232

<400> 232
000


<210> 233

<400> 233
000


<210> 234

<400> 234
000


<210> 235

<400> 235
000


<210> 236

<400> 236
000


<210> 237

<400> 237
000


<210> 238

<400> 238
000


<210> 239

<400> 239
000


<210> 240

<400> 240
000


<210> 241

<400> 241
000


<210> 242

<400> 242
000


<210> 243

<400> 243
000


<210> 244

<400> 244
000


<210> 245

<400> 245
000


<210> 246

<400> 246
000


<210> 247

<400> 247
000


<210> 248

<400> 248
000


<210> 249

<400> 249
000


<210> 250

<400> 250
000


<210> 251

<400> 251
000


<210> 252

<400> 252
000


<210> 253

<400> 253
000


<210> 254

<400> 254
000


<210> 255

<400> 255
000


<210> 256

<400> 256
000


<210> 257

<400> 257
000


<210> 258

<400> 258
000


<210> 259

<400> 259
000


<210> 260

<400> 260
000


<210> 261

<400> 261
000


<210> 262

<400> 262
000


<210> 263

<400> 263
000


<210> 264

<400> 264
000


<210> 265

<400> 265
000


<210> 266

<400> 266
000


<210> 267

<400> 267
000


<210> 268
<211> 839
<212> PRT
<213> Homo sapiens

<400> 268
Asp Asp Pro Asn Ser Ser Asp Glu Ser Asn Gly Asn Asp Asp Ala Asn 
1               5                   10                  15      


Ser Glu Ser Asp Asn Asn Ser Ser Ser Arg Gly Asp Ala Ser Tyr Asn 
            20                  25                  30          


Ser Asp Glu Ser Lys Asp Asn Gly Asn Gly Ser Asp Ser Lys Gly Ala 
        35                  40                  45              


Glu Asp Asp Asp Ser Asp Ser Thr Ser Asp Thr Asn Asn Ser Asp Ser 
    50                  55                  60                  


Asn Gly Asn Gly Asn Asn Gly Asn Asp Asp Asn Asp Lys Ser Asp Ser 
65                  70                  75                  80  


Gly Lys Gly Lys Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser 
                85                  90                  95      


Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser 
            100                 105                 110         


Asn Ser Ser Ser Asp Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser 
        115                 120                 125             


Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp 
    130                 135                 140                 


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
145                 150                 155                 160 


Lys Ser Asp Ser Ser Lys Ser Glu Ser Asp Ser Ser Asp Ser Asp Ser 
                165                 170                 175     


Lys Ser Asp Ser Ser Asp Ser Asn Ser Ser Asp Ser Ser Asp Asn Ser 
            180                 185                 190         


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asn Ser Ser Asp Ser Ser Asp 
        195                 200                 205             


Ser Ser Asp Ser Ser Asp Ser Ser Ser Ser Ser Asp Ser Ser Asn Ser 
    210                 215                 220                 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Glu Ser Ser 
225                 230                 235                 240 


Asp Ser Ser Asp Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asp Ser 
                245                 250                 255     


Ser Asn Ser Asn Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser 
            260                 265                 270         


Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
        275                 280                 285             


Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
    290                 295                 300                 


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser 
305                 310                 315                 320 


Ser Asp Ser Asn Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser 
                325                 330                 335     


Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp 
            340                 345                 350         


Ser Ser Asp Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser 
        355                 360                 365             


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp 
    370                 375                 380                 


Ser Ser Asp Gly Ser Asp Ser Asp Ser Ser Asn Arg Ser Asp Ser Ser 
385                 390                 395                 400 


Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
                405                 410                 415     


Ser Ser Asp Ser Ser Asp Ser Asn Glu Ser Ser Asn Ser Ser Asp Ser 
            420                 425                 430         


Ser Asp Ser Ser Asn Ser Ser Asp Ser Asp Ser Ser Asp Ser Ser Asn 
        435                 440                 445             


Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Glu Ser 
    450                 455                 460                 


Ser Asn Ser Ser Asp Asn Ser Asn Ser Ser Asp Ser Ser Asn Ser Ser 
465                 470                 475                 480 


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asn 
                485                 490                 495     


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Asn Ser Ser 
            500                 505                 510         


Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp 
        515                 520                 525             


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser 
    530                 535                 540                 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser 
545                 550                 555                 560 


Asn Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp 
                565                 570                 575     


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
            580                 585                 590         


Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
        595                 600                 605             


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Glu Ser Ser Asp 
    610                 615                 620                 


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
625                 630                 635                 640 


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
                645                 650                 655     


Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp 
            660                 665                 670         


Ser Ser Asp Ser Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Glu Ser 
        675                 680                 685             


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
    690                 695                 700                 


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asn Ser Ser Asp 
705                 710                 715                 720 


Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
                725                 730                 735     


Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser 
            740                 745                 750         


Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp 
        755                 760                 765             


Ser Asn Glu Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser 
    770                 775                 780                 


Ser Asn Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Ser Asp Ser Thr 
785                 790                 795                 800 


Ser Asp Ser Asn Asp Glu Ser Asp Ser Gln Ser Lys Ser Gly Asn Gly 
                805                 810                 815     


Asn Asn Asn Gly Ser Asp Ser Asp Ser Asp Ser Glu Gly Ser Asp Ser 
            820                 825                 830         


Asn His Ser Thr Ser Asp Asp 
        835                 


<210> 269

<400> 269
000


<210> 270

<400> 270
000


<210> 271

<400> 271
000


<210> 272

<400> 272
000


<210> 273

<400> 273
000


<210> 274

<400> 274
000


<210> 275

<400> 275
000


<210> 276

<400> 276
000


<210> 277

<400> 277
000


<210> 278

<400> 278
000


<210> 279

<400> 279
000


<210> 280

<400> 280
000


<210> 281

<400> 281
000


<210> 282

<400> 282
000


<210> 283

<400> 283
000


<210> 284

<400> 284
000


<210> 285

<400> 285
000


<210> 286

<400> 286
000


<210> 287

<400> 287
000


<210> 288

<400> 288
000


<210> 289

<400> 289
000


<210> 290

<400> 290
000


<210> 291

<400> 291
000


<210> 292

<400> 292
000


<210> 293

<400> 293
000


<210> 294

<400> 294
000


<210> 295

<400> 295
000


<210> 296

<400> 296
000


<210> 297

<400> 297
000


<210> 298

<400> 298
000


<210> 299

<400> 299
000


<210> 300

<400> 300
000


<210> 301

<400> 301
000


<210> 302

<400> 302
000


<210> 303

<400> 303
000


<210> 304

<400> 304
000


<210> 305

<400> 305
000


<210> 306

<400> 306
000


<210> 307

<400> 307
000


<210> 308

<400> 308
000


<210> 309

<400> 309
000


<210> 310

<400> 310
000


<210> 311

<400> 311
000


<210> 312

<400> 312
000


<210> 313

<400> 313
000


<210> 314

<400> 314
000


<210> 315

<400> 315
000


<210> 316

<400> 316
000


<210> 317

<400> 317
000


<210> 318

<400> 318
000


<210> 319

<400> 319
000


<210> 320

<400> 320
000


<210> 321

<400> 321
000


<210> 322

<400> 322
000


<210> 323

<400> 323
000


<210> 324

<400> 324
000


<210> 325

<400> 325
000


<210> 326

<400> 326
000


<210> 327

<400> 327
000


<210> 328

<400> 328
000


<210> 329

<400> 329
000


<210> 330

<400> 330
000


<210> 331

<400> 331
000


<210> 332

<400> 332
000


<210> 333

<400> 333
000


<210> 334

<400> 334
000


<210> 335

<400> 335
000


<210> 336

<400> 336
000


<210> 337

<400> 337
000


<210> 338

<400> 338
000


<210> 339

<400> 339
000


<210> 340

<400> 340
000


<210> 341

<400> 341
000


<210> 342

<400> 342
000


<210> 343

<400> 343
000


<210> 344

<400> 344
000


<210> 345

<400> 345
000


<210> 346

<400> 346
000


<210> 347

<400> 347
000


<210> 348

<400> 348
000


<210> 349

<400> 349
000


<210> 350

<400> 350
000


<210> 351

<400> 351
000


<210> 352

<400> 352
000


<210> 353

<400> 353
000


<210> 354

<400> 354
000


<210> 355

<400> 355
000


<210> 356

<400> 356
000


<210> 357

<400> 357
000


<210> 358

<400> 358
000


<210> 359

<400> 359
000


<210> 360

<400> 360
000


<210> 361

<400> 361
000


<210> 362

<400> 362
000


<210> 363

<400> 363
000


<210> 364

<400> 364
000


<210> 365

<400> 365
000


<210> 366

<400> 366
000


<210> 367

<400> 367
000


<210> 368

<400> 368
000


<210> 369

<400> 369
000


<210> 370

<400> 370
000


<210> 371

<400> 371
000


<210> 372

<400> 372
000


<210> 373

<400> 373
000


<210> 374

<400> 374
000


<210> 375

<400> 375
000


<210> 376

<400> 376
000


<210> 377

<400> 377
000


<210> 378

<400> 378
000


<210> 379

<400> 379
000


<210> 380

<400> 380
000


<210> 381

<400> 381
000


<210> 382

<400> 382
000


<210> 383

<400> 383
000


<210> 384

<400> 384
000


<210> 385

<400> 385
000


<210> 386

<400> 386
000


<210> 387

<400> 387
000


<210> 388

<400> 388
000


<210> 389

<400> 389
000


<210> 390

<400> 390
000


<210> 391

<400> 391
000


<210> 392

<400> 392
000


<210> 393

<400> 393
000


<210> 394

<400> 394
000


<210> 395

<400> 395
000


<210> 396

<400> 396
000


<210> 397

<400> 397
000


<210> 398

<400> 398
000


<210> 399

<400> 399
000


<210> 400

<400> 400
000


<210> 401
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 401
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


<210> 402
<211> 48
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 402
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu 
1               5                   10                  15      


Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


<210> 403
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 403
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa 
    1415     


<210> 404
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 404
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa 
    1415     


<210> 405
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 405
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa 
    1415     


<210> 406
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 406
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa 
    1415     


<210> 407
<211> 1416
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 407
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa 
    1415     


<210> 408
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 408
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 409
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 409
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 410
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 410
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 411
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 411
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 412
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 412
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 413
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 413
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 414
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 414
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 415
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 415
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 416
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 416
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 417
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 417
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 418
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT"
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 418
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 419
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 419
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 420
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 420
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 421
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 421
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 422
<211> 60
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 422
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210> 423

<400> 423
000


<210> 424

<400> 424
000


<210> 425

<400> 425
000


<210> 426

<400> 426
000


<210> 427

<400> 427
000


<210> 428

<400> 428
000


<210> 429

<400> 429
000


<210> 430

<400> 430
000


<210> 431

<400> 431
000


<210> 432

<400> 432
000


<210> 433

<400> 433
000


<210> 434

<400> 434
000


<210> 435

<400> 435
000


<210> 436

<400> 436
000


<210> 437

<400> 437
000


<210> 438

<400> 438
000


<210> 439

<400> 439
000


<210> 440

<400> 440
000


<210> 441

<400> 441
000


<210> 442

<400> 442
000


<210> 443

<400> 443
000


<210> 444

<400> 444
000


<210> 445

<400> 445
000


<210> 446

<400> 446
000


<210> 447

<400> 447
000


<210> 448

<400> 448
000


<210> 449

<400> 449
000


<210> 450

<400> 450
000


<210> 451

<400> 451
000


<210> 452

<400> 452
000


<210> 453

<400> 453
000


<210> 454

<400> 454
000


<210> 455

<400> 455
000


<210> 456

<400> 456
000


<210> 457

<400> 457
000


<210> 458

<400> 458
000


<210> 459

<400> 459
000


<210> 460

<400> 460
000


<210> 461

<400> 461
000


<210> 462

<400> 462
000


<210> 463

<400> 463
000


<210> 464

<400> 464
000


<210> 465

<400> 465
000


<210> 466

<400> 466
000


<210> 467

<400> 467
000


<210> 468

<400> 468
000


<210> 469

<400> 469
000


<210> 470

<400> 470
000


<210> 471

<400> 471
000


<210> 472

<400> 472
000


<210> 473

<400> 473
000


<210> 474

<400> 474
000


<210> 475

<400> 475
000


<210> 476

<400> 476
000


<210> 477

<400> 477
000


<210> 478

<400> 478
000


<210> 479

<400> 479
000


<210> 480

<400> 480
000


<210> 481

<400> 481
000


<210> 482

<400> 482
000


<210> 483

<400> 483
000


<210> 484

<400> 484
000


<210> 485

<400> 485
000


<210> 486

<400> 486
000


<210> 487

<400> 487
000


<210> 488

<400> 488
000


<210> 489

<400> 489
000


<210> 490

<400> 490
000


<210> 491

<400> 491
000


<210> 492

<400> 492
000


<210> 493

<400> 493
000


<210> 494

<400> 494
000


<210> 495

<400> 495
000


<210> 496

<400> 496
000


<210> 497

<400> 497
000


<210> 498

<400> 498
000


<210> 499

<400> 499
000


<210> 500

<400> 500
000


<210> 501
<211> 152
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 501
Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr 
1               5                   10                  15      


Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser 
            20                  25                  30          


Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu 
        35                  40                  45              


Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val 
    50                  55                  60                  


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr 
65                  70                  75                  80  


Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
                85                  90                  95      


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile 
            100                 105                 110         


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
        115                 120                 125             


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
    130                 135                 140                 


Val Val Glu Gly Cys Gly Cys Arg 
145                 150         


<210> 502
<211> 217
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 502
Met Pro Ile Gly Ser Leu Leu Ala Asp Thr Thr His His Arg Pro Trp 
1               5                   10                  15      


Thr Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ile Ile Gly 
            20                  25                  30          


Glu Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His 
        35                  40                  45              


His Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His Lys Pro Trp 
    50                  55                  60                  


Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly 
65                  70                  75                  80  


Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala 
                85                  90                  95      


Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg 
            100                 105                 110         


Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp 
        115                 120                 125             


Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe 
    130                 135                 140                 


Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser 
145                 150                 155                 160 


Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys 
                165                 170                 175     


Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met 
            180                 185                 190         


Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp 
        195                 200                 205             


Met Val Val Glu Gly Cys Gly Cys Arg 
    210                 215         


<210> 503
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 503
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 504
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 504
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu 
1               5                   10                  15      


Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr 
    50                  55                  60                  


Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu 
                85                  90                  95      


Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val 
            100                 105                 110         


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr 
        115                 120                 125             


Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
    130                 135                 140                 


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile 
145                 150                 155                 160 


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                165                 170                 175     


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
            180                 185                 190         


Val Val Glu Gly Cys Gly Cys Arg 
        195                 200 


<210> 505
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 505
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His 
            20                  25                  30          


Lys Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser 
        35                  40                  45              


Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly 
    50                  55                  60                  


Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln 
65                  70                  75                  80  


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
                85                  90                  95      


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
            100                 105                 110         


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
        115                 120                 125             


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
    130                 135                 140                 


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
145                 150                 155                 160 


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
                165                 170                 175     


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            180                 185             


<210> 506
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 506
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
    50                  55                  60                  


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
65                  70                  75                  80  


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
                85                  90                  95      


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
            100                 105                 110         


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
        115                 120                 125             


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
    130                 135                 140                 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
145                 150                 155                 160 


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 175     


<210> 507
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 507
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 508
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, L, I, G, S, T or A

<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, V, Q, T, S, G or A

<220>
<221> MOD_RES
<222> (3)..(3)
<223> G, A, V or S

<220>
<221> MOD_RES
<222> (4)..(4)
<223> E, D, L or G

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, T, P T, E or D

<220>
<221> MOD_RES
<222> (6)..(6)
<223> T or S

<220>
<221> MOD_RES
<222> (7)..(7)
<223> H, T or S

<220>
<221> MOD_RES
<222> (8)..(8)
<223> H or T

<220>
<221> MOD_RES
<222> (9)..(9)
<223> R, S, K, P or H

<220>
<221> MOD_RES
<222> (10)..(10)
<223> P, S, R or K

<220>
<221> MOD_RES
<222> (11)..(11)
<223> W, F, S, P, V, A or G

<220>
<221> MOD_RES
<222> (12)..(12)
<223> absent or is S, T G, or A

<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 508
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 509
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, L, I, G, S, T or A

<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, V, Q, T, S, G or A

<220>
<221> MOD_RES
<222> (3)..(3)
<223> G, A, V or S

<220>
<221> MOD_RES
<222> (4)..(4)
<223> E, D, L or G

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, T, P T, E or D

<220>
<221> MOD_RES
<222> (6)..(6)
<223> T or S

<220>
<221> MOD_RES
<222> (7)..(7)
<223> H, T or S

<220>
<221> MOD_RES
<222> (8)..(8)
<223> H or T

<220>
<221> MOD_RES
<222> (9)..(9)
<223> R, S, K, P or H

<220>
<221> MOD_RES
<222> (10)..(10)
<223> P, S, R or K

<220>
<221> MOD_RES
<222> (11)..(11)
<223> W, F, S, P, V, A or G

<220>
<221> MOD_RES
<222> (12)..(12)
<223> absent or is S, T G, or A

<400> 509
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 510
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 510
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 511
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 511
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 512
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 512
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 513
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 513
Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 514
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 514
Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 515
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 515
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 516
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 516
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 517
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 517
Ile Leu Ala Glu Thr Thr His His Arg Pro Trp Ser Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 518
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 518
Ile Leu Ala Glu Thr Thr His His Arg Pro Trp Ser Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 519
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 519
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 520
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 520
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 521
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 521
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 522
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 522
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 523
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 523
Val Leu Gly Asp Thr Thr His His Lys Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 524
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 524
Val Leu Gly Asp Thr Thr His His Lys Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 525
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 525
Ile Val Ala Asp Ser Thr His His Arg Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 526
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 526
Ile Val Ala Asp Ser Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 527
<211> 125
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (11)..(12)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 527
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Gln Ala Lys His Lys 
1               5                   10                  15      


Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val 
            20                  25                  30          


Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly 
        35                  40                  45              


Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp 
    50                  55                  60                  


His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser 
65                  70                  75                  80  


Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser 
                85                  90                  95      


Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys 
            100                 105                 110         


Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125 


<210> 528
<211> 163
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 528
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Ala Ser Gly Ala Gly 
1               5                   10                  15      


Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly 
            20                  25                  30          


Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr 
        35                  40                  45              


Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys 
    50                  55                  60                  


Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp 
65                  70                  75                  80  


Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys 
                85                  90                  95      


Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val 
            100                 105                 110         


Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys 
        115                 120                 125             


Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn 
    130                 135                 140                 


Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys 
145                 150                 155                 160 


Gly Cys Arg 
            


<210> 529
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 529
Thr Ser Gly Gly Glu Ser Thr His His Arg Pro Ser Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 530
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 530
Thr Ser Gly Gly Glu Ser Thr His His Arg Pro Ser Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 531
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 531
Thr Ser Gly Gly Glu Ser Ser His His Lys Pro Ser Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 532
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 532
Thr Ser Gly Gly Glu Ser Ser His His Lys Pro Ser Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 533
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 533
Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 534
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 534
Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 535
<211> 127
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (13)..(14)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 535
Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr Gln Ala Lys 
1               5                   10                  15      


His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu 
            20                  25                  30          


Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro 
        35                  40                  45              


Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu 
    50                  55                  60                  


Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val 
65                  70                  75                  80  


Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu 
                85                  90                  95      


Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val 
            100                 105                 110         


Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125         


<210> 536
<211> 165
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 536
Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr Ala Ser Gly 
1               5                   10                  15      


Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala 
            20                  25                  30          


Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly 
        35                  40                  45              


Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser 
    50                  55                  60                  


Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn 
65                  70                  75                  80  


Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly 
                85                  90                  95      


Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala 
            100                 105                 110         


Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala 
        115                 120                 125             


Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp 
    130                 135                 140                 


Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu 
145                 150                 155                 160 


Gly Cys Gly Cys Arg 
                165 


<210> 537
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 537
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 538
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 538
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 539
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 539
Gly Ala Ala Asp Thr Thr His His Arg Pro Val Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 540
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 540
Gly Ala Ala Asp Thr Thr His His Arg Pro Val Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 541
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 541
Ala Gly Ala Asp Thr Thr His His Arg Pro Val Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 542
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 542
Ala Gly Ala Asp Thr Thr His His Arg Pro Val Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 543
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 543
Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 544
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 544
Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 545
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 545
Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 546
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 546
Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 547
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (24)..(25)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 547
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Gln Ala Lys His Lys Gln Arg Lys 
            20                  25                  30          


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
        35                  40                  45              


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
    50                  55                  60                  


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
65                  70                  75                  80  


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
                85                  90                  95      


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
        115                 120                 125             


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
    130                 135             


<210> 548
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 548
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ala Ser Gly Ala Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
    50                  55                  60                  


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
65                  70                  75                  80  


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
                85                  90                  95      


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
            100                 105                 110         


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
        115                 120                 125             


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
    130                 135                 140                 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
145                 150                 155                 160 


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 175     


<210> 549
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (36)..(37)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 549
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser 
        35                  40                  45              


Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp 
    50                  55                  60                  


Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His 
65                  70                  75                  80  


Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His 
                85                  90                  95      


Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys 
            100                 105                 110         


Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu 
        115                 120                 125             


Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val 
    130                 135                 140                 


Glu Gly Cys Gly Cys Arg 
145                 150 


<210> 550
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 550
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser 
        35                  40                  45              


Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly 
    50                  55                  60                  


Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln 
65                  70                  75                  80  


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
                85                  90                  95      


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
            100                 105                 110         


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
        115                 120                 125             


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
    130                 135                 140                 


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
145                 150                 155                 160 


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
                165                 170                 175     


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            180                 185             


<210> 551
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 551
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 552
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 552
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 553
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (24)..(25)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 553
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Gln Ala Lys His Lys Gln Arg Lys 
            20                  25                  30          


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
        35                  40                  45              


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
    50                  55                  60                  


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
65                  70                  75                  80  


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
                85                  90                  95      


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
        115                 120                 125             


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
    130                 135             


<210> 554
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 554
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
    50                  55                  60                  


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
65                  70                  75                  80  


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
                85                  90                  95      


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
            100                 105                 110         


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
        115                 120                 125             


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
    130                 135                 140                 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
145                 150                 155                 160 


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 175     


<210> 555
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 555
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 556
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 556
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ile Leu Ala Glu 
1               5                   10                  15      


Ser Thr His His Lys Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 557
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (24)..(25)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 557
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Gln Ala Lys His Lys Gln Arg Lys 
            20                  25                  30          


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
        35                  40                  45              


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
    50                  55                  60                  


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
65                  70                  75                  80  


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
                85                  90                  95      


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
        115                 120                 125             


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
    130                 135             


<210> 558
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 558
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Ala Ser Gly Ala Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
    50                  55                  60                  


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
65                  70                  75                  80  


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
                85                  90                  95      


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
            100                 105                 110         


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
        115                 120                 125             


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
    130                 135                 140                 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
145                 150                 155                 160 


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 175     


<210> 559
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (36)..(37)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 559
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser 
        35                  40                  45              


Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp 
    50                  55                  60                  


Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His 
65                  70                  75                  80  


Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His 
                85                  90                  95      


Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys 
            100                 105                 110         


Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu 
        115                 120                 125             


Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val 
    130                 135                 140                 


Glu Gly Cys Gly Cys Arg 
145                 150 


<210> 560
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 560
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser 
        35                  40                  45              


Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly 
    50                  55                  60                  


Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln 
65                  70                  75                  80  


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
                85                  90                  95      


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
            100                 105                 110         


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
        115                 120                 125             


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
    130                 135                 140                 


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
145                 150                 155                 160 


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
                165                 170                 175     


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            180                 185             


<210> 561
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 561
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 562
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 562
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 563
<211> 198
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (84)..(85)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 563
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
    50                  55                  60                  


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
65                  70                  75                  80  


Arg Pro Trp Thr Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser 
                85                  90                  95      


Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp 
            100                 105                 110         


Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His 
        115                 120                 125             


Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His 
    130                 135                 140                 


Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys 
145                 150                 155                 160 


Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu 
                165                 170                 175     


Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val 
            180                 185                 190         


Glu Gly Cys Gly Cys Arg 
        195             


<210> 564
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 564
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gly Leu Gly Asp 
    50                  55                  60                  


Thr Thr His His Arg Pro Trp Gly Leu Leu Ala Asp Thr Thr His His 
65                  70                  75                  80  


Arg Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser 
                85                  90                  95      


Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly 
            100                 105                 110         


Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln 
        115                 120                 125             


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
    130                 135                 140                 


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
145                 150                 155                 160 


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
                165                 170                 175     


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
            180                 185                 190         


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
        195                 200                 205             


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
    210                 215                 220                 


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
225                 230                 235     


<210> 565
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 565
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Thr Ser Gly Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Ser Thr Ser Gly Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Ser Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser Gly 
        35                  40                  45              


Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 566
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 566
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Thr Ser Gly Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Ser Thr Ser Gly Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Ser Thr Gly Ser Gly Asp Ser Ser His His Arg Pro Ser Gly 
        35                  40                  45              


Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 567
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 567
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Gly Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Val Thr Ala Gly Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Val Thr Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr 
        35                  40                  45              


Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 568
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 568
Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Gly Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Val Thr Ala Gly Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Val Thr Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr 
        35                  40                  45              


Gly Gly Ala Asp Thr Thr His His Arg Pro Gly Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 569
<211> 222
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (108)..(109)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 569
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Leu Leu Ala Asp Thr 
1               5                   10                  15      


Thr His His Arg Pro Trp Thr Thr Ser Gly Gly Glu Ser Thr His His 
            20                  25                  30          


Arg Pro Ser Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Thr 
        35                  40                  45              


Ser Gly Gly Glu Ser Ser His His Lys Pro Ser Gly Ala Ala Asp Thr 
    50                  55                  60                  


Thr His His Arg Pro Val Thr Thr Gly Ser Gly Asp Ser Ser His His 
65                  70                  75                  80  


Arg Pro Ser Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr 
                85                  90                  95      


Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr Gln Ala Lys His 
            100                 105                 110         


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
        115                 120                 125             


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
    130                 135                 140                 


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
145                 150                 155                 160 


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
                165                 170                 175     


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
            180                 185                 190         


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
        195                 200                 205             


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
    210                 215                 220         


<210> 570
<211> 260
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 570
Ser Thr Ala Asp Thr Ser His His Arg Pro Ser Leu Leu Ala Asp Thr 
1               5                   10                  15      


Thr His His Arg Pro Trp Thr Thr Ser Gly Gly Glu Ser Thr His His 
            20                  25                  30          


Arg Pro Ser Val Gly Ala Asp Ser Thr His His Arg Pro Val Thr Thr 
        35                  40                  45              


Ser Gly Gly Glu Ser Ser His His Lys Pro Ser Gly Ala Ala Asp Thr 
    50                  55                  60                  


Thr His His Arg Pro Val Thr Thr Gly Ser Gly Asp Ser Ser His His 
65                  70                  75                  80  


Arg Pro Ser Gly Ser Ser Gly Glu Ser Thr His His Lys Pro Ser Thr 
                85                  90                  95      


Gly Gly Ala Asp Thr Thr His His Arg Pro Ala Thr Ala Ser Gly Ala 
            100                 105                 110         


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
        115                 120                 125             


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
    130                 135                 140                 


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
145                 150                 155                 160 


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
                165                 170                 175     


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
            180                 185                 190         


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
        195                 200                 205             


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
    210                 215                 220                 


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
225                 230                 235                 240 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
                245                 250                 255     


Cys Gly Cys Arg 
            260 


<210> 571
<211> 228
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (114)..(115)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 571
Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
        115                 120                 125             


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
    130                 135                 140                 


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
145                 150                 155                 160 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
                165                 170                 175     


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
            180                 185                 190         


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
        195                 200                 205             


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
    210                 215                 220                 


Cys Gly Cys Arg 
225             


<210> 572
<211> 266
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 572
Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
1               5                   10                  15      


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
            20                  25                  30          


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
        35                  40                  45              


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
    50                  55                  60                  


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
65                  70                  75                  80  


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
                85                  90                  95      


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
            100                 105                 110         


Cys Arg Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly 
        115                 120                 125             


Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly 
    130                 135                 140                 


Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys 
145                 150                 155                 160 


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
                165                 170                 175     


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
            180                 185                 190         


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
        195                 200                 205             


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
    210                 215                 220                 


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
225                 230                 235                 240 


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
                245                 250                 255     


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            260                 265     


<210> 573
<211> 151
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (37)..(38)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 573
Thr Gly Gly Ser Gly Glu Gly Gly Thr Gly Ala Ser Thr Gly Gly Ser 
1               5                   10                  15      


Ala Gly Thr Gly Gly Ser Gly Gly Thr Thr Ser Gly Glu Ala Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys 
        35                  40                  45              


Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly 
    50                  55                  60                  


Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys 
65                  70                  75                  80  


His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn 
                85                  90                  95      


His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro 
            100                 105                 110         


Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr 
        115                 120                 125             


Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val 
    130                 135                 140                 


Val Glu Gly Cys Gly Cys Arg 
145                 150     


<210> 574
<211> 189
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 574
Thr Gly Gly Ser Gly Glu Gly Gly Thr Gly Ala Ser Thr Gly Gly Ser 
1               5                   10                  15      


Ala Gly Thr Gly Gly Ser Gly Gly Thr Thr Ser Gly Glu Ala Gly Gly 
            20                  25                  30          


Ser Ser Gly Ala Gly Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly 
        35                  40                  45              


Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser 
    50                  55                  60                  


Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys 
65                  70                  75                  80  


Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val 
                85                  90                  95      


Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly 
            100                 105                 110         


Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp 
        115                 120                 125             


His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser 
    130                 135                 140                 


Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser 
145                 150                 155                 160 


Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys 
                165                 170                 175     


Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            180                 185                 


<210> 575
<211> 119
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (5)..(6)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 575
Gly Ala Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys 
1               5                   10                  15      


Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly 
            20                  25                  30          


Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys 
        35                  40                  45              


His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn 
    50                  55                  60                  


His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro 
65                  70                  75                  80  


Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr 
                85                  90                  95      


Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val 
            100                 105                 110         


Val Glu Gly Cys Gly Cys Arg 
        115                 


<210> 576
<211> 157
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 576
Gly Ala Gly Thr Gly Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly 
1               5                   10                  15      


Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser 
            20                  25                  30          


Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys 
        35                  40                  45              


Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val 
    50                  55                  60                  


Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly 
65                  70                  75                  80  


Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp 
                85                  90                  95      


His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser 
            100                 105                 110         


Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser 
        115                 120                 125             


Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys 
    130                 135                 140                 


Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
145                 150                 155         


<210> 577
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, L, I, G, S, T or A

<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, V, Q, T, S, G or A

<220>
<221> MOD_RES
<222> (3)..(3)
<223> G, A, V or S

<220>
<221> MOD_RES
<222> (4)..(4)
<223> E, D, L or G

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, T, P T, E or D

<220>
<221> MOD_RES
<222> (6)..(6)
<223> T or S

<220>
<221> MOD_RES
<222> (7)..(7)
<223> H, T or S

<220>
<221> MOD_RES
<222> (8)..(8)
<223> H or T

<220>
<221> MOD_RES
<222> (9)..(9)
<223> R, S, K, P or H

<220>
<221> MOD_RES
<222> (10)..(10)
<223> P, S, R or K

<220>
<221> MOD_RES
<222> (11)..(11)
<223> W, F, S, P, V, A or G

<220>
<221> MOD_RES
<222> (12)..(12)
<223> absent or is S, T G, or A

<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 577
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 578
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> V, L, I, G, S, T or A

<220>
<221> MOD_RES
<222> (2)..(2)
<223> I, L, V, Q, T, S, G or A

<220>
<221> MOD_RES
<222> (3)..(3)
<223> G, A, V or S

<220>
<221> MOD_RES
<222> (4)..(4)
<223> E, D, L or G

<220>
<221> MOD_RES
<222> (5)..(5)
<223> S, T, P T, E or D

<220>
<221> MOD_RES
<222> (6)..(6)
<223> T or S

<220>
<221> MOD_RES
<222> (7)..(7)
<223> H, T or S

<220>
<221> MOD_RES
<222> (8)..(8)
<223> H or T

<220>
<221> MOD_RES
<222> (9)..(9)
<223> R, S, K, P or H

<220>
<221> MOD_RES
<222> (10)..(10)
<223> P, S, R or K

<220>
<221> MOD_RES
<222> (11)..(11)
<223> W, F, S, P, V, A or G

<220>
<221> MOD_RES
<222> (12)..(12)
<223> absent or is S, T G, or A

<400> 578
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 579
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 579
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 580
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 580
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
1               5                   10                  15      


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
            20                  25                  30          


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
        35                  40                  45              


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
    50                  55                  60                  


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
65                  70                  75                  80  


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
                85                  90                  95      


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
            100                 105                 110         


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
        115                 120                 125             


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
    130                 135                 140                 


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
145                 150                 155                 160 


Cys Gly Cys Arg 
                


<210> 581
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 581
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 582
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 582
Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Ala Ala Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 583
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 583
Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 584
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 584
Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Ala Ala His His Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Ala Ala His His Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 585
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 585
Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 586
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 586
Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr Ala Ala Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr Ala Ala Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 587
<211> 138
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (24)..(25)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 587
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His Lys Gln Arg Lys 
            20                  25                  30          


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
        35                  40                  45              


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
    50                  55                  60                  


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
65                  70                  75                  80  


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
                85                  90                  95      


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
            100                 105                 110         


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
        115                 120                 125             


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
    130                 135             


<210> 588
<211> 176
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 588
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu 
            20                  25                  30          


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
        35                  40                  45              


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
    50                  55                  60                  


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
65                  70                  75                  80  


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
                85                  90                  95      


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
            100                 105                 110         


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
        115                 120                 125             


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
    130                 135                 140                 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
145                 150                 155                 160 


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 175     


<210> 589
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (36)..(37)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 589
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser 
        35                  40                  45              


Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp 
    50                  55                  60                  


Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His 
65                  70                  75                  80  


Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His 
                85                  90                  95      


Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys 
            100                 105                 110         


Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu 
        115                 120                 125             


Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val 
    130                 135                 140                 


Glu Gly Cys Gly Cys Arg 
145                 150 


<210> 590
<211> 188
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 590
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser 
        35                  40                  45              


Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly 
    50                  55                  60                  


Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln 
65                  70                  75                  80  


Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp 
                85                  90                  95      


Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr 
            100                 105                 110         


His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His 
        115                 120                 125             


Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val 
    130                 135                 140                 


Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala 
145                 150                 155                 160 


Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn 
                165                 170                 175     


Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            180                 185             


<210> 591
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 591
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 592
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 592
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp 
1               5                   10                  15      


Thr Thr His His Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Thr Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr 
        35                  40                  45              


Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 593
<211> 234
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (120)..(121)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 593
Ser Thr Ser Gly Ser Thr Val Ile Gly Glu Ser Thr His His Arg Pro 
1               5                   10                  15      


Trp Ser Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr Ile Leu 
            20                  25                  30          


Ala Glu Ser Thr His His Lys Pro Trp Thr Ile Leu Ala Glu Thr Thr 
        35                  40                  45              


His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His Lys Pro 
    50                  55                  60                  


Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Val Leu 
65                  70                  75                  80  


Gly Asp Thr Thr His His Lys Pro Trp Thr Ile Val Ala Asp Ser Thr 
                85                  90                  95      


His His Arg Pro Trp Thr Gly Gln Val Leu Pro Thr Thr Thr Pro Ser 
            100                 105                 110         


Ser Pro Ser Thr Thr Ser Gly Ser Gln Ala Lys His Lys Gln Arg Lys 
        115                 120                 125             


Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser 
    130                 135                 140                 


Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala 
145                 150                 155                 160 


Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn 
                165                 170                 175     


Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser 
            180                 185                 190         


Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser 
        195                 200                 205             


Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln 
    210                 215                 220                 


Asp Met Val Val Glu Gly Cys Gly Cys Arg 
225                 230                 


<210> 594
<211> 272
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 594
Ser Thr Ser Gly Ser Thr Val Ile Gly Glu Ser Thr His His Arg Pro 
1               5                   10                  15      


Trp Ser Leu Ile Ala Asp Ser Thr His His Ser Pro Trp Thr Ile Leu 
            20                  25                  30          


Ala Glu Ser Thr His His Lys Pro Trp Thr Ile Leu Ala Glu Thr Thr 
        35                  40                  45              


His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His Lys Pro 
    50                  55                  60                  


Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Val Leu 
65                  70                  75                  80  


Gly Asp Thr Thr His His Lys Pro Trp Thr Ile Val Ala Asp Ser Thr 
                85                  90                  95      


His His Arg Pro Trp Thr Gly Gln Val Leu Pro Thr Thr Thr Pro Ser 
            100                 105                 110         


Ser Pro Ser Thr Thr Ser Gly Ser Ala Ser Gly Ala Gly Gly Ser Glu 
        115                 120                 125             


Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr Gly Ala Gly Thr 
    130                 135                 140                 


Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly Thr Gly Gln Ala 
145                 150                 155                 160 


Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro 
                165                 170                 175     


Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala 
            180                 185                 190         


Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro 
        195                 200                 205             


Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu 
    210                 215                 220                 


Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr 
225                 230                 235                 240 


Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val 
                245                 250                 255     


Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
            260                 265                 270         


<210> 595
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (48)..(49)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 595
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
    50                  55                  60                  


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
65                  70                  75                  80  


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
                85                  90                  95      


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
            100                 105                 110         


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
        115                 120                 125             


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
    130                 135                 140                 


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
145                 150                 155                 160 


Cys Arg 
        


<210> 596
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 596
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Val Ile Gly Glu 
1               5                   10                  15      


Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu Ser Ser His His 
            20                  25                  30          


Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly 
        35                  40                  45              


Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr 
    50                  55                  60                  


Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu 
                85                  90                  95      


Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val 
            100                 105                 110         


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr 
        115                 120                 125             


Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
    130                 135                 140                 


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile 
145                 150                 155                 160 


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                165                 170                 175     


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
            180                 185                 190         


Val Val Glu Gly Cys Gly Cys Arg 
        195                 200 


<210> 597
<211> 162
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (48)..(49)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 597
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu 
1               5                   10                  15      


Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg 
    50                  55                  60                  


His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile 
65                  70                  75                  80  


Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro 
                85                  90                  95      


Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln 
            100                 105                 110         


Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val 
        115                 120                 125             


Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu 
    130                 135                 140                 


Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly 
145                 150                 155                 160 


Cys Arg 
        


<210> 598
<211> 200
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 598
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Ile Ile Gly Glu 
1               5                   10                  15      


Ser Ser His His Lys Pro Phe Thr Gly Leu Gly Asp Thr Thr His His 
            20                  25                  30          


Arg Pro Trp Gly Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr 
        35                  40                  45              


Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr 
    50                  55                  60                  


Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser 
65                  70                  75                  80  


Thr Gly Gly Gly Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu 
                85                  90                  95      


Lys Ser Ser Cys Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val 
            100                 105                 110         


Gly Trp Asn Asp Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr 
        115                 120                 125             


Cys His Gly Glu Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr 
    130                 135                 140                 


Asn His Ala Ile Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile 
145                 150                 155                 160 


Pro Lys Ala Cys Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu 
                165                 170                 175     


Tyr Leu Asp Glu Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met 
            180                 185                 190         


Val Val Glu Gly Cys Gly Cys Arg 
        195                 200 


<210> 599
<211> 1530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220>
<221> NON_CONS
<222> (1416)..(1417)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 599
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Gln Ala Lys His  Lys Gln Arg Lys Arg  Leu Lys Ser 
    1415                 1420                 1425             


Ser Cys  Lys Arg His Pro Leu  Tyr Val Asp Phe Ser  Asp Val Gly 
    1430                 1435                 1440             


Trp Asn  Asp Trp Ile Val Ala  Pro Pro Gly Tyr His  Ala Phe Tyr 
    1445                 1450                 1455             


Cys His  Gly Glu Cys Pro Phe  Pro Leu Ala Asp His  Leu Asn Ser 
    1460                 1465                 1470             


Thr Asn  His Ala Ile Val Gln  Thr Leu Val Asn Ser  Val Asn Ser 
    1475                 1480                 1485             


Lys Ile  Pro Lys Ala Cys Cys  Val Pro Thr Glu Leu  Ser Ala Ile 
    1490                 1495                 1500             


Ser Met  Leu Tyr Leu Asp Glu  Asn Glu Lys Val Val  Leu Lys Asn 
    1505                 1510                 1515             


Tyr Gln  Asp Met Val Val Glu  Gly Cys Gly Cys Arg  
    1520                 1525                 1530 


<210> 600
<211> 1568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 600
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Ala Ser Gly Ala  Gly Gly Ser Glu Gly  Gly Gly Ser 
    1415                 1420                 1425             


Glu Gly  Gly Thr Ser Gly Ala  Thr Gly Ala Gly Thr  Ser Thr Ser 
    1430                 1435                 1440             


Gly Gly  Gly Ala Ser Thr Gly  Gly Gly Thr Gly Gln  Ala Lys His 
    1445                 1450                 1455             


Lys Gln  Arg Lys Arg Leu Lys  Ser Ser Cys Lys Arg  His Pro Leu 
    1460                 1465                 1470             


Tyr Val  Asp Phe Ser Asp Val  Gly Trp Asn Asp Trp  Ile Val Ala 
    1475                 1480                 1485             


Pro Pro  Gly Tyr His Ala Phe  Tyr Cys His Gly Glu  Cys Pro Phe 
    1490                 1495                 1500             


Pro Leu  Ala Asp His Leu Asn  Ser Thr Asn His Ala  Ile Val Gln 
    1505                 1510                 1515             


Thr Leu  Val Asn Ser Val Asn  Ser Lys Ile Pro Lys  Ala Cys Cys 
    1520                 1525                 1530             


Val Pro  Thr Glu Leu Ser Ala  Ile Ser Met Leu Tyr  Leu Asp Glu 
    1535                 1540                 1545             


Asn Glu  Lys Val Val Leu Lys  Asn Tyr Gln Asp Met  Val Val Glu 
    1550                 1555                 1560             


Gly Cys  Gly Cys Arg 
    1565             


<210> 601
<211> 1530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220>
<221> NON_CONS
<222> (1416)..(1417)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 601
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Gln Ala Lys His  Lys Gln Arg Lys Arg  Leu Lys Ser 
    1415                 1420                 1425             


Ser Cys  Lys Arg His Pro Leu  Tyr Val Asp Phe Ser  Asp Val Gly 
    1430                 1435                 1440             


Trp Asn  Asp Trp Ile Val Ala  Pro Pro Gly Tyr His  Ala Phe Tyr 
    1445                 1450                 1455             


Cys His  Gly Glu Cys Pro Phe  Pro Leu Ala Asp His  Leu Asn Ser 
    1460                 1465                 1470             


Thr Asn  His Ala Ile Val Gln  Thr Leu Val Asn Ser  Val Asn Ser 
    1475                 1480                 1485             


Lys Ile  Pro Lys Ala Cys Cys  Val Pro Thr Glu Leu  Ser Ala Ile 
    1490                 1495                 1500             


Ser Met  Leu Tyr Leu Asp Glu  Asn Glu Lys Val Val  Leu Lys Asn 
    1505                 1510                 1515             


Tyr Gln  Asp Met Val Val Glu  Gly Cys Gly Cys Arg  
    1520                 1525                 1530 


<210> 602
<211> 1568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 602
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Ala Ser Gly Ala  Gly Gly Ser Glu Gly  Gly Gly Ser 
    1415                 1420                 1425             


Glu Gly  Gly Thr Ser Gly Ala  Thr Gly Ala Gly Thr  Ser Thr Ser 
    1430                 1435                 1440             


Gly Gly  Gly Ala Ser Thr Gly  Gly Gly Thr Gly Gln  Ala Lys His 
    1445                 1450                 1455             


Lys Gln  Arg Lys Arg Leu Lys  Ser Ser Cys Lys Arg  His Pro Leu 
    1460                 1465                 1470             


Tyr Val  Asp Phe Ser Asp Val  Gly Trp Asn Asp Trp  Ile Val Ala 
    1475                 1480                 1485             


Pro Pro  Gly Tyr His Ala Phe  Tyr Cys His Gly Glu  Cys Pro Phe 
    1490                 1495                 1500             


Pro Leu  Ala Asp His Leu Asn  Ser Thr Asn His Ala  Ile Val Gln 
    1505                 1510                 1515             


Thr Leu  Val Asn Ser Val Asn  Ser Lys Ile Pro Lys  Ala Cys Cys 
    1520                 1525                 1530             


Val Pro  Thr Glu Leu Ser Ala  Ile Ser Met Leu Tyr  Leu Asp Glu 
    1535                 1540                 1545             


Asn Glu  Lys Val Val Leu Lys  Asn Tyr Gln Asp Met  Val Val Glu 
    1550                 1555                 1560             


Gly Cys  Gly Cys Arg 
    1565             


<210> 603
<211> 1530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220>
<221> NON_CONS
<222> (1416)..(1417)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 603
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Gln Ala Lys His  Lys Gln Arg Lys Arg  Leu Lys Ser 
    1415                 1420                 1425             


Ser Cys  Lys Arg His Pro Leu  Tyr Val Asp Phe Ser  Asp Val Gly 
    1430                 1435                 1440             


Trp Asn  Asp Trp Ile Val Ala  Pro Pro Gly Tyr His  Ala Phe Tyr 
    1445                 1450                 1455             


Cys His  Gly Glu Cys Pro Phe  Pro Leu Ala Asp His  Leu Asn Ser 
    1460                 1465                 1470             


Thr Asn  His Ala Ile Val Gln  Thr Leu Val Asn Ser  Val Asn Ser 
    1475                 1480                 1485             


Lys Ile  Pro Lys Ala Cys Cys  Val Pro Thr Glu Leu  Ser Ala Ile 
    1490                 1495                 1500             


Ser Met  Leu Tyr Leu Asp Glu  Asn Glu Lys Val Val  Leu Lys Asn 
    1505                 1510                 1515             


Tyr Gln  Asp Met Val Val Glu  Gly Cys Gly Cys Arg  
    1520                 1525                 1530 


<210> 604
<211> 1568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 604
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Ala Ser Gly Ala  Gly Gly Ser Glu Gly  Gly Gly Ser 
    1415                 1420                 1425             


Glu Gly  Gly Thr Ser Gly Ala  Thr Gly Ala Gly Thr  Ser Thr Ser 
    1430                 1435                 1440             


Gly Gly  Gly Ala Ser Thr Gly  Gly Gly Thr Gly Gln  Ala Lys His 
    1445                 1450                 1455             


Lys Gln  Arg Lys Arg Leu Lys  Ser Ser Cys Lys Arg  His Pro Leu 
    1460                 1465                 1470             


Tyr Val  Asp Phe Ser Asp Val  Gly Trp Asn Asp Trp  Ile Val Ala 
    1475                 1480                 1485             


Pro Pro  Gly Tyr His Ala Phe  Tyr Cys His Gly Glu  Cys Pro Phe 
    1490                 1495                 1500             


Pro Leu  Ala Asp His Leu Asn  Ser Thr Asn His Ala  Ile Val Gln 
    1505                 1510                 1515             


Thr Leu  Val Asn Ser Val Asn  Ser Lys Ile Pro Lys  Ala Cys Cys 
    1520                 1525                 1530             


Val Pro  Thr Glu Leu Ser Ala  Ile Ser Met Leu Tyr  Leu Asp Glu 
    1535                 1540                 1545             


Asn Glu  Lys Val Val Leu Lys  Asn Tyr Gln Asp Met  Val Val Glu 
    1550                 1555                 1560             


Gly Cys  Gly Cys Arg 
    1565             


<210> 605
<211> 1530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220>
<221> NON_CONS
<222> (1416)..(1417)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 605
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Gln Ala Lys His  Lys Gln Arg Lys Arg  Leu Lys Ser 
    1415                 1420                 1425             


Ser Cys  Lys Arg His Pro Leu  Tyr Val Asp Phe Ser  Asp Val Gly 
    1430                 1435                 1440             


Trp Asn  Asp Trp Ile Val Ala  Pro Pro Gly Tyr His  Ala Phe Tyr 
    1445                 1450                 1455             


Cys His  Gly Glu Cys Pro Phe  Pro Leu Ala Asp His  Leu Asn Ser 
    1460                 1465                 1470             


Thr Asn  His Ala Ile Val Gln  Thr Leu Val Asn Ser  Val Asn Ser 
    1475                 1480                 1485             


Lys Ile  Pro Lys Ala Cys Cys  Val Pro Thr Glu Leu  Ser Ala Ile 
    1490                 1495                 1500             


Ser Met  Leu Tyr Leu Asp Glu  Asn Glu Lys Val Val  Leu Lys Asn 
    1505                 1510                 1515             


Tyr Gln  Asp Met Val Val Glu  Gly Cys Gly Cys Arg  
    1520                 1525                 1530 


<210> 606
<211> 1568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 606
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Ala Ser Gly Ala  Gly Gly Ser Glu Gly  Gly Gly Ser 
    1415                 1420                 1425             


Glu Gly  Gly Thr Ser Gly Ala  Thr Gly Ala Gly Thr  Ser Thr Ser 
    1430                 1435                 1440             


Gly Gly  Gly Ala Ser Thr Gly  Gly Gly Thr Gly Gln  Ala Lys His 
    1445                 1450                 1455             


Lys Gln  Arg Lys Arg Leu Lys  Ser Ser Cys Lys Arg  His Pro Leu 
    1460                 1465                 1470             


Tyr Val  Asp Phe Ser Asp Val  Gly Trp Asn Asp Trp  Ile Val Ala 
    1475                 1480                 1485             


Pro Pro  Gly Tyr His Ala Phe  Tyr Cys His Gly Glu  Cys Pro Phe 
    1490                 1495                 1500             


Pro Leu  Ala Asp His Leu Asn  Ser Thr Asn His Ala  Ile Val Gln 
    1505                 1510                 1515             


Thr Leu  Val Asn Ser Val Asn  Ser Lys Ile Pro Lys  Ala Cys Cys 
    1520                 1525                 1530             


Val Pro  Thr Glu Leu Ser Ala  Ile Ser Met Leu Tyr  Leu Asp Glu 
    1535                 1540                 1545             


Asn Glu  Lys Val Val Leu Lys  Asn Tyr Gln Asp Met  Val Val Glu 
    1550                 1555                 1560             


Gly Cys  Gly Cys Arg 
    1565             


<210> 607
<211> 1530
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220>
<221> NON_CONS
<222> (1416)..(1417)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 607
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Gln Ala Lys His  Lys Gln Arg Lys Arg  Leu Lys Ser 
    1415                 1420                 1425             


Ser Cys  Lys Arg His Pro Leu  Tyr Val Asp Phe Ser  Asp Val Gly 
    1430                 1435                 1440             


Trp Asn  Asp Trp Ile Val Ala  Pro Pro Gly Tyr His  Ala Phe Tyr 
    1445                 1450                 1455             


Cys His  Gly Glu Cys Pro Phe  Pro Leu Ala Asp His  Leu Asn Ser 
    1460                 1465                 1470             


Thr Asn  His Ala Ile Val Gln  Thr Leu Val Asn Ser  Val Asn Ser 
    1475                 1480                 1485             


Lys Ile  Pro Lys Ala Cys Cys  Val Pro Thr Glu Leu  Ser Ala Ile 
    1490                 1495                 1500             


Ser Met  Leu Tyr Leu Asp Glu  Asn Glu Lys Val Val  Leu Lys Asn 
    1505                 1510                 1515             


Tyr Gln  Asp Met Val Val Glu  Gly Cys Gly Cys Arg  
    1520                 1525                 1530 


<210> 608
<211> 1568
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(1416)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "LIADSTHHSPWT" or 
      "ILAESTHHKPWT" or "ILAETTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG" or "VLGDTTHHKPWT" or "IVADSTHHRPWT" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "STADTSHHRPS" or "TSGGESTHHRPS" or 
      "TSGGESSHHKPS" or "TGSGDSSHHRPS" or "GSSGESTHHKPST" or 
      "VGADSTHHRPVT" or "GAADTTHHRPVT" or "AGADTTHHRPVT" or 
      "GGADTTHHRPAT" or "GGADTTHHRPGT" or "LLADTTHHRPWTVIGESTHHRPWS" 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFT" or 
      "LLADTTHHRPWTVIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAESTHHKPWT"
       or "LLADTTHHRPWTILAESTHHKPWT" or "LLADTTHHRPWTILAESTHHKPWTLLAD
       TTHHRPWTILAESTHHKPWTLLADTTHHRPWT" or "LLADTTHHRPWTGLGDTTHHRPWG"

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT" or 
      "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWT"
       or "LLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRPWTGLGDTTHHRPWGLLADTTHHRP
       WTGLGDTTHHRPWGLLADTTHHRPWT" or "STADTSHHRPSTSGGESTHHRPSTSGGESS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: HHKPSTGSGDSSHHRPSGSSGESTHHKPST" or "VGADSTHHR
      PVTGAADTTHHRPVTAGADTTHHRPVTGGADTTHHRPATGGADTTHHRPGT" or "STADTS
      HHRPSLLADTTHHRPWTTSGGESTHHRPSVGADSTHHRPVTTSGGESSHHKPSGAADTTHHRP
      VTTGSGDSSHHRPSGSSGESTHHKPSTGGADTTHHRPAT" or "XXXXXXXXXXXX" or 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: "AAADTTHHRPWT" or "AAADTTHHRPWTAAADTTHHRPWTAA
      ADTTHHRPWTAAADTTHHRPWTAAADTTHHRPWT" or "LLADAAHHRPWTLLADAAHHRPW
      TLLADAAHHRPWTLLADAAHHRPWTLLADAAHHRPWT" or "LLADTTAARPWTLLADTTAA
      RPWTLLADTTAARPWTLLADTTAARPWTLLADTTAARPWT" or "LLADTTHHRPWTLLADT

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: THHRPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHH
      RPWT" or "LLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADTTHHRPWTLLADT
      THHRPWT" or "STSGSTVIGESTHHRPWSLIADSTHHSPWTILAESTHHKPWTILAETTHH
      RPWSIIGESSHHKPFTGLGDTTHHRPWGVLGDTTHHKPWTIVADSTHHRPWTGQVLPTTTPSS

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: PSTTSGS" or "LLADTTHHRPWTVIGESTHHRPWSIIGESSHH
      KPFTGLGDTTHHRPWG" or "VIGESTHHRPWSIIGESSHHKPFTGLGDTTHHRPWGILAE
      STHHKPWT" and wherein X's respectively = V, L, I, G, S, T or A;
       I, L, V, Q, T, S, G or A; G, A, V or S; E, D, L or G; S, T, P 

<220>
<221> MOD_RES
<222> (13)..(1416)
<223> CONT. FROM ABOVE: T, E or D; T or S; H, T or S; H or T; R, S,
      K, P or H; P, S, R or K; W, F, S, P, V, A or G; and absent, S,
      T G, or A

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 608
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1010                 1015                 1020             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1025                 1030                 1035             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1040                 1045                 1050             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1055                 1060                 1065             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1160                 1165                 1170             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1175                 1180                 1185             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1190                 1195                 1200             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Ala Ser Gly Ala  Gly Gly Ser Glu Gly  Gly Gly Ser 
    1415                 1420                 1425             


Glu Gly  Gly Thr Ser Gly Ala  Thr Gly Ala Gly Thr  Ser Thr Ser 
    1430                 1435                 1440             


Gly Gly  Gly Ala Ser Thr Gly  Gly Gly Thr Gly Gln  Ala Lys His 
    1445                 1450                 1455             


Lys Gln  Arg Lys Arg Leu Lys  Ser Ser Cys Lys Arg  His Pro Leu 
    1460                 1465                 1470             


Tyr Val  Asp Phe Ser Asp Val  Gly Trp Asn Asp Trp  Ile Val Ala 
    1475                 1480                 1485             


Pro Pro  Gly Tyr His Ala Phe  Tyr Cys His Gly Glu  Cys Pro Phe 
    1490                 1495                 1500             


Pro Leu  Ala Asp His Leu Asn  Ser Thr Asn His Ala  Ile Val Gln 
    1505                 1510                 1515             


Thr Leu  Val Asn Ser Val Asn  Ser Lys Ile Pro Lys  Ala Cys Cys 
    1520                 1525                 1530             


Val Pro  Thr Glu Leu Ser Ala  Ile Ser Met Leu Tyr  Leu Asp Glu 
    1535                 1540                 1545             


Asn Glu  Lys Val Val Leu Lys  Asn Tyr Gln Asp Met  Val Val Glu 
    1550                 1555                 1560             


Gly Cys  Gly Cys Arg 
    1565             


<210> 609
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 609
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 610
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 610
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 611
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 611
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 612
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 612
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 613
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 613
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 614
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 614
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 615
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 615
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 616
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 616
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 617
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 617
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 618
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass one or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 618
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 619
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 619
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 620
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 620
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 621
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 621
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 622
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 622
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 623
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 623
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 624
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 624
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 625
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 625
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 626
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" or 
      "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 626
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 627
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 627
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 628
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass two or more of the following sequences:
      "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" or 
      "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 628
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 629
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT"
      or "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 629
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 630
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "VIGESTHHRPWS" or "ILAESTHHKPWT" or "IIGESSHHKPFT"
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 630
Leu Leu Ala Asp Thr Thr His His Arg Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 631
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 631
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 632
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 632
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 633
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 633
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 634
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "VIGESTHHRPWS" or "IIGESSHHKPFT" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 634
Ile Leu Ala Glu Ser Thr His His Lys Pro Trp Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 635
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" 
      or "GLGDTTHHRPWG"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 635
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 636
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "VIGESTHHRPWS" 
      or "GLGDTTHHRPWG"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 636
Ile Ile Gly Glu Ser Ser His His Lys Pro Phe Thr Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 637
<211> 174
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "VIGESTHHRPWS"

<220>
<221> NON_CONS
<222> (60)..(61)
<223> Residues at these positions can be separated by
      a linker of unknown length

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 637
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gln Ala Lys His 
    50                  55                  60                  


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
65                  70                  75                  80  


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
                85                  90                  95      


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
            100                 105                 110         


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
        115                 120                 125             


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
    130                 135                 140                 


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
145                 150                 155                 160 


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
                165                 170                 


<210> 638
<211> 212
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (13)..(60)
<223> This region may encompass three or more of the following 
      sequences: "LLADTTHHRPWT" or "ILAESTHHKPWT" or "IIGESSHHKPFT" 
      or "VIGESTHHRPWS"

<220> 
<223> See specification as filed for detailed description of
      substitutions and preferred embodiments

<400> 638
Gly Leu Gly Asp Thr Thr His His Arg Pro Trp Gly Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Ser Gly Ala 
    50                  55                  60                  


Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr Ser Gly Ala Thr 
65                  70                  75                  80  


Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser Thr Gly Gly Gly 
                85                  90                  95      


Thr Gly Gln Ala Lys His Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys 
            100                 105                 110         


Lys Arg His Pro Leu Tyr Val Asp Phe Ser Asp Val Gly Trp Asn Asp 
        115                 120                 125             


Trp Ile Val Ala Pro Pro Gly Tyr His Ala Phe Tyr Cys His Gly Glu 
    130                 135                 140                 


Cys Pro Phe Pro Leu Ala Asp His Leu Asn Ser Thr Asn His Ala Ile 
145                 150                 155                 160 


Val Gln Thr Leu Val Asn Ser Val Asn Ser Lys Ile Pro Lys Ala Cys 
                165                 170                 175     


Cys Val Pro Thr Glu Leu Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu 
            180                 185                 190         


Asn Glu Lys Val Val Leu Lys Asn Tyr Gln Asp Met Val Val Glu Gly 
        195                 200                 205             


Cys Gly Cys Arg 
    210         


<210> 639
<211> 126
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> NON_CONS
<222> (12)..(13)
<223> Residues at these positions can be separated by
      a linker of unknown length

<400> 639
Val Ile Gly Glu Ser Thr His His Arg Pro Trp Ser Gln Ala Lys His 
1               5                   10                  15      


Lys Gln Arg Lys Arg Leu Lys Ser Ser Cys Lys Arg His Pro Leu Tyr 
            20                  25                  30          


Val Asp Phe Ser Asp Val Gly Trp Asn Asp Trp Ile Val Ala Pro Pro 
        35                  40                  45              


Gly Tyr His Ala Phe Tyr Cys His Gly Glu Cys Pro Phe Pro Leu Ala 
    50                  55                  60                  


Asp His Leu Asn Ser Thr Asn His Ala Ile Val Gln Thr Leu Val Asn 
65                  70                  75                  80  


Ser Val Asn Ser Lys Ile Pro Lys Ala Cys Cys Val Pro Thr Glu Leu 
                85                  90                  95      


Ser Ala Ile Ser Met Leu Tyr Leu Asp Glu Asn Glu Lys Val Val Leu 
            100                 105                 110         


Lys Asn Tyr Gln Asp Met Val Val Glu Gly Cys Gly Cys Arg 
        115                 120                 125     


<210> 640

<400> 640
000


<210> 641

<400> 641
000


<210> 642

<400> 642
000


<210> 643

<400> 643
000


<210> 644

<400> 644
000


<210> 645

<400> 645
000


<210> 646

<400> 646
000


<210> 647

<400> 647
000


<210> 648

<400> 648
000


<210> 649

<400> 649
000


<210> 650

<400> 650
000


<210> 651

<400> 651
000


<210> 652

<400> 652
000


<210> 653

<400> 653
000


<210> 654

<400> 654
000


<210> 655

<400> 655
000


<210> 656

<400> 656
000


<210> 657

<400> 657
000


<210> 658

<400> 658
000


<210> 659

<400> 659
000


<210> 660

<400> 660
000


<210> 661

<400> 661
000


<210> 662

<400> 662
000


<210> 663

<400> 663
000


<210> 664

<400> 664
000


<210> 665

<400> 665
000


<210> 666

<400> 666
000


<210> 667

<400> 667
000


<210> 668

<400> 668
000


<210> 669

<400> 669
000


<210> 670

<400> 670
000


<210> 671

<400> 671
000


<210> 672

<400> 672
000


<210> 673

<400> 673
000


<210> 674

<400> 674
000


<210> 675

<400> 675
000


<210> 676

<400> 676
000


<210> 677

<400> 677
000


<210> 678

<400> 678
000


<210> 679

<400> 679
000


<210> 680

<400> 680
000


<210> 681

<400> 681
000


<210> 682

<400> 682
000


<210> 683

<400> 683
000


<210> 684

<400> 684
000


<210> 685

<400> 685
000


<210> 686

<400> 686
000


<210> 687

<400> 687
000


<210> 688

<400> 688
000


<210> 689

<400> 689
000


<210> 690

<400> 690
000


<210> 691

<400> 691
000


<210> 692

<400> 692
000


<210> 693

<400> 693
000


<210> 694

<400> 694
000


<210> 695

<400> 695
000


<210> 696

<400> 696
000


<210> 697

<400> 697
000


<210> 698

<400> 698
000


<210> 699

<400> 699
000


<210> 700

<400> 700
000


<210> 701
<211> 38
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 701
Ala Ser Gly Ala Gly Gly Ser Glu Gly Gly Gly Ser Glu Gly Gly Thr 
1               5                   10                  15      


Ser Gly Ala Thr Gly Ala Gly Thr Ser Thr Ser Gly Gly Gly Ala Ser 
            20                  25                  30          


Thr Gly Gly Gly Thr Gly 
        35              


<210> 702
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 702
Gly Ser Glu Gly 
1               


<210> 703
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 703
Ser Glu Gly Gly 
1               


<210> 704
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 704
Met Pro Ile Gly Ser 
1               5   


<210> 705
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 705
Gly Ser Gly Ser 
1               


<210> 706
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 706
Gly Ser Gly Ser Gly Ser 
1               5       


<210> 707
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 707
Ser Gly Ser Gly 
1               


<210> 708
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 708
Ser Gly Ser Gly Ser Gly 
1               5       


<210> 709
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 709
Gly Ser Ser Gly 
1               


<210> 710
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 710
Gly Gly Gly Gly Ser 
1               5   


<210> 711
<211> 17
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 711
aaataaaata cgaaatg                                                      17


