                               SEQUENCE LISTING

<110> ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
 
<120> CHIMERIC MYD88 RECEPTORS

<130> 243734.000147

<140>
<141>

<150> 63/059,534
<151> 2020-07-31

<150> 63/009,761
<151> 2020-04-14

<160> 45    

<170> PatentIn version 3.5

<210> 1
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser 
            


<210> 2
<211> 57
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
atggattgga tatggcgaat cttgttcctc gtcggtgccg cgaccggcgc tcactct          57


<210> 3
<211> 246
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 3
Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Gly Gly 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Asp Ser 
            20                  25                  30          


Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp Ala Leu Lys 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu 
    130                 135                 140                 


Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu 
145                 150                 155                 160 


Ser Val Asp Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr Gln Gln Lys 
                165                 170                 175     


Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu 
            180                 185                 190         


Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe 
        195                 200                 205             


Thr Leu Thr Ile Asp Pro Val Gln Ala Glu Asp Ala Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Gln Gln Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Glu Ile Lys Asp Leu 
                245     


<210> 4
<211> 738
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
gaggtgcaac ttaaagagag tggccctggt ctggtggctc ctggtggaag cttgtctatc       60

acgtgtacag tatccggatt tagcttgaca gacagttcaa tcaattgggt acgccaacct      120

ccgggtaaag gtctggagtg gctcggaatg atatggggtg acggtcggat agattacgct      180

gatgcattga aatctaggct cagcatatct aaggactcta gcaagagtca ggtttttctg      240

gagatgacga gtctccgcac ggacgacacc gcaacctact attgtgccag ggatggctat      300

tttccctatg cgatggactt ctggggccaa ggaacgagtg tcaccgtcag ttcaggaggt      360

ggcggctctg gaggtggagg cagtgggggc ggtggctctg acattgtgtt gacccaaagc      420

ccagcctcct tggcggttag ccttggacag agggcaacaa tctcttgtcg ggccagcgag      480

tccgtggaca gctacggaca gtcatatatg cattggtacc agcagaaggc gggtcaaccc      540

cccaagctcc tcatatactt ggcttctaat ttggagagtg gggttcctgc gagattttcc      600

ggatctggtt ctaggactga cttcacgttg acgatagatc ccgtacaggc agaagacgca      660

gcaacctact actgccaaca aaatgcggag gactcaagaa catttggggg cggtaccaag      720

cttgaaatta aggatctc                                                    738


<210> 5
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210> 6
<211> 45
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccg                       45


<210> 7
<211> 27
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210> 8
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ttttgggtgc tggtggtggt tggtggagtc ctggcttgct atagcttgct agtaacagtg       60

gcctttatta ttttctgggt g                                                 81


<210> 9
<211> 171
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser Thr 
1               5                   10                  15      


Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg Leu 
            20                  25                  30          


Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr Ala 
        35                  40                  45              


Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu Glu 
    50                  55                  60                  


Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly Arg 
65                  70                  75                  80  


Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu Gly 
                85                  90                  95      


Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp Cys 
            100                 105                 110         


Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro Leu 
        115                 120                 125             


Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu Ala 
    130                 135                 140                 


Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg Phe 
145                 150                 155                 160 


Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile 
                165                 170     


<210> 10
<211> 513
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
gctgctggcg gacctggcgc cggatctgct gctcctgtgt ctagcacaag cagcctgcct       60

ctggccgccc tgaacatgag agtgcggaga aggctgagcc tgttcctgaa cgtgcggaca      120

caggtggccg ccgattggac agccctggcc gaggaaatgg acttcgagta cctggaaatc      180

cggcagctgg aaacccaggc cgaccctaca ggcagactgc tggatgcttg gcagggcaga      240

ccaggcgctt ctgtgggaag gctgctggaa ctgctgacca agctgggcag ggacgacgtg      300

ctgctggaac tgggccctag catcgaagag gactgccaga agtacatcct gaagcagcag      360

caggaagagg ccgagaagcc tctgcaggtg gcagccgtgg atagcagcgt gccaagaaca      420

gccgagctgg ccggcatcac caccctggat gatcctctgg gccacatgcc cgagagattc      480

gacgccttca tctgctactg ccccagcgac atc                                   513


<210> 11
<211> 18
<212> PRT
<213> Thosea asigna virus

<400> 11
Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn Pro 
1               5                   10                  15      


Gly Pro 
        


<210> 12
<211> 54
<212> DNA
<213> Thosea asigna virus

<400> 12
gagggcagag gcagcctgct gacatgtggc gacgtggaag agaacccagg cccc             54


<210> 13
<211> 333
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu Thr Pro Met 
1               5                   10                  15      


Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu Glu Gly Asp 
            20                  25                  30          


Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly Pro Thr Gln 
        35                  40                  45              


Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe Leu Lys Leu 
    50                  55                  60                  


Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro Leu Ala Ile 
65                  70                  75                  80  


Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly Phe Tyr Leu 
                85                  90                  95      


Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro Gly Trp Thr 
            100                 105                 110         


Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn Val Ser Asp 
        115                 120                 125             


Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser Glu Gly Pro 
    130                 135                 140                 


Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr Val Trp Ala 
145                 150                 155                 160 


Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys Leu Pro Pro 
                165                 170                 175     


Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr Met Ala Pro 
            180                 185                 190         


Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp Ser Val Ser 
        195                 200                 205             


Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly Pro Lys Ser 
    210                 215                 220                 


Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg Asp Met Trp 
225                 230                 235                 240 


Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala Gln Asp Ala 
                245                 250                 255     


Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser Phe His Leu 
            260                 265                 270         


Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu Arg Thr Gly 
        275                 280                 285             


Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile Phe Cys Leu 
    290                 295                 300                 


Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu Val Leu Arg 
305                 310                 315                 320 


Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe 
                325                 330             


<210> 14
<211> 999
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
atgcctcccc ccagactgct gttcttcctg ctgttcctga cccctatgga agtgcggccc       60

gaggaacccc tggtcgtgaa agtggaagag ggcgacaacg ccgtgctgca gtgtctgaag      120

ggcacctccg atggccctac ccagcagctg acctggtcca gagagagccc cctgaagccc      180

ttcctgaagc tgtctctggg cctgcctggc ctgggcatcc atatgaggcc actggccatc      240

tggctgttca tcttcaacgt gtcccagcag atgggaggct tctacctgtg ccagcctggc      300

ccaccttctg agaaggcttg gcagcctggc tggaccgtga acgtggaagg atctggcgag      360

ctgttccggt ggaacgtgtc cgatctgggc ggcctgggat gcggcctgaa gaacagatct      420

agcgagggcc ccagcagccc cagcggcaaa ctgatgagcc ccaagctgta cgtgtgggcc      480

aaggacagac ccgagatttg ggagggcgag cccccttgcc tgccccctag agatagcctg      540

aaccagagcc tgagccagga cctgacaatg gcccctggca gcacactgtg gctgagctgt      600

ggcgtgccac ccgactctgt gtctagaggc cctctgagct ggacccacgt gcaccctaag      660

ggccctaaga gcctgctgtc cctggaactg aaggacgaca ggcccgccag agatatgtgg      720

gtcatggaaa ccggcctgct gctgcctaga gccacagccc aggatgccgg caagtactac      780

tgccacagag gcaacctgac catgagcttc cacctggaaa tcaccgccag acccgtgctg      840

tggcactggc tgctgagaac cggcggatgg aaagtgtccg ccgtgactct ggcctacctg      900

atcttctgcc tgtgctccct cgtgggcatc ctgcatctgc agagggctct ggtgctgcgg      960

cggaagcgga agagaatgac cgaccctacc cggcggttc                             999


<210> 15
<211> 481
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr 
            180                 185                 190         


Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
        195                 200                 205             


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln Ala Glu Asp Ala Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Asp Leu Glu Pro Lys Ser Cys Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala 
305                 310                 315                 320 


Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met 
                325                 330                 335     


Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val 
            340                 345                 350         


Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu 
        355                 360                 365             


Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu 
    370                 375                 380                 


Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu 
385                 390                 395                 400 


Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro 
                405                 410                 415     


Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu 
            420                 425                 430         


Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro 
        435                 440                 445             


Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
    450                 455                 460                 


His Met Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp 
465                 470                 475                 480 


Ile 
    


<210> 16
<211> 1443
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
atggattgga tatggcgaat cttgttcctc gtcggtgccg cgaccggcgc tcactctgag       60

gtgcaactta aagagagtgg ccctggtctg gtggctcctg gtggaagctt gtctatcacg      120

tgtacagtat ccggatttag cttgacagac agttcaatca attgggtacg ccaacctccg      180

ggtaaaggtc tggagtggct cggaatgata tggggtgacg gtcggataga ttacgctgat      240

gcattgaaat ctaggctcag catatctaag gactctagca agagtcaggt ttttctggag      300

atgacgagtc tccgcacgga cgacaccgca acctactatt gtgccaggga tggctatttt      360

ccctatgcga tggacttctg gggccaagga acgagtgtca ccgtcagttc aggaggtggc      420

ggctctggag gtggaggcag tgggggcggt ggctctgaca ttgtgttgac ccaaagccca      480

gcctccttgg cggttagcct tggacagagg gcaacaatct cttgtcgggc cagcgagtcc      540

gtggacagct acggacagtc atatatgcat tggtaccagc agaaggcggg tcaacccccc      600

aagctcctca tatacttggc ttctaatttg gagagtgggg ttcctgcgag attttccgga      660

tctggttcta ggactgactt cacgttgacg atagatcccg tacaggcaga agacgcagca      720

acctactact gccaacaaaa tgcggaggac tcaagaacat ttgggggcgg taccaagctt      780

gaaattaagg atctcgagcc caaatcttgt gacaaaactc acacatgccc accgtgcccg      840

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      900

gtaacagtgg cctttattat tttctgggtg gctgctggcg gacctggcgc cggatctgct      960

gctcctgtgt ctagcacaag cagcctgcct ctggccgccc tgaacatgag agtgcggaga     1020

aggctgagcc tgttcctgaa cgtgcggaca caggtggccg ccgattggac agccctggcc     1080

gaggaaatgg acttcgagta cctggaaatc cggcagctgg aaacccaggc cgaccctaca     1140

ggcagactgc tggatgcttg gcagggcaga ccaggcgctt ctgtgggaag gctgctggaa     1200

ctgctgacca agctgggcag ggacgacgtg ctgctggaac tgggccctag catcgaagag     1260

gactgccaga agtacatcct gaagcagcag caggaagagg ccgagaagcc tctgcaggtg     1320

gcagccgtgg atagcagcgt gccaagaaca gccgagctgg ccggcatcac caccctggat     1380

gatcctctgg gccacatgcc cgagagattc gacgccttca tctgctactg ccccagcgac     1440

atc                                                                   1443


<210> 17
<211> 832
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Asp Trp Ile Trp Arg Ile Leu Phe Leu Val Gly Ala Ala Thr Gly 
1               5                   10                  15      


Ala His Ser Glu Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala 
            20                  25                  30          


Pro Gly Gly Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              


Thr Asp Ser Ser Ile Asn Trp Val Arg Gln Pro Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Leu Gly Met Ile Trp Gly Asp Gly Arg Ile Asp Tyr Ala Asp 
65                  70                  75                  80  


Ala Leu Lys Ser Arg Leu Ser Ile Ser Lys Asp Ser Ser Lys Ser Gln 
                85                  90                  95      


Val Phe Leu Glu Met Thr Ser Leu Arg Thr Asp Asp Thr Ala Thr Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Asp Gly Tyr Phe Pro Tyr Ala Met Asp Phe Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
145                 150                 155                 160 


Ala Ser Leu Ala Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Arg 
                165                 170                 175     


Ala Ser Glu Ser Val Asp Ser Tyr Gly Gln Ser Tyr Met His Trp Tyr 
            180                 185                 190         


Gln Gln Lys Ala Gly Gln Pro Pro Lys Leu Leu Ile Tyr Leu Ala Ser 
        195                 200                 205             


Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg 
    210                 215                 220                 


Thr Asp Phe Thr Leu Thr Ile Asp Pro Val Gln Ala Glu Asp Ala Ala 
225                 230                 235                 240 


Thr Tyr Tyr Cys Gln Gln Asn Ala Glu Asp Ser Arg Thr Phe Gly Gly 
                245                 250                 255     


Gly Thr Lys Leu Glu Ile Lys Asp Leu Glu Pro Lys Ser Cys Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Asp Pro Lys Phe Trp Val Leu Val 
        275                 280                 285             


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
    290                 295                 300                 


Phe Ile Ile Phe Trp Val Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala 
305                 310                 315                 320 


Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met 
                325                 330                 335     


Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val 
            340                 345                 350         


Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu 
        355                 360                 365             


Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu 
    370                 375                 380                 


Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu 
385                 390                 395                 400 


Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro 
                405                 410                 415     


Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu 
            420                 425                 430         


Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro 
        435                 440                 445             


Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
    450                 455                 460                 


His Met Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp 
465                 470                 475                 480 


Ile Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu Glu Asn 
                485                 490                 495     


Pro Gly Pro Met Pro Pro Pro Arg Leu Leu Phe Phe Leu Leu Phe Leu 
            500                 505                 510         


Thr Pro Met Glu Val Arg Pro Glu Glu Pro Leu Val Val Lys Val Glu 
        515                 520                 525             


Glu Gly Asp Asn Ala Val Leu Gln Cys Leu Lys Gly Thr Ser Asp Gly 
    530                 535                 540                 


Pro Thr Gln Gln Leu Thr Trp Ser Arg Glu Ser Pro Leu Lys Pro Phe 
545                 550                 555                 560 


Leu Lys Leu Ser Leu Gly Leu Pro Gly Leu Gly Ile His Met Arg Pro 
                565                 570                 575     


Leu Ala Ile Trp Leu Phe Ile Phe Asn Val Ser Gln Gln Met Gly Gly 
            580                 585                 590         


Phe Tyr Leu Cys Gln Pro Gly Pro Pro Ser Glu Lys Ala Trp Gln Pro 
        595                 600                 605             


Gly Trp Thr Val Asn Val Glu Gly Ser Gly Glu Leu Phe Arg Trp Asn 
    610                 615                 620                 


Val Ser Asp Leu Gly Gly Leu Gly Cys Gly Leu Lys Asn Arg Ser Ser 
625                 630                 635                 640 


Glu Gly Pro Ser Ser Pro Ser Gly Lys Leu Met Ser Pro Lys Leu Tyr 
                645                 650                 655     


Val Trp Ala Lys Asp Arg Pro Glu Ile Trp Glu Gly Glu Pro Pro Cys 
            660                 665                 670         


Leu Pro Pro Arg Asp Ser Leu Asn Gln Ser Leu Ser Gln Asp Leu Thr 
        675                 680                 685             


Met Ala Pro Gly Ser Thr Leu Trp Leu Ser Cys Gly Val Pro Pro Asp 
    690                 695                 700                 


Ser Val Ser Arg Gly Pro Leu Ser Trp Thr His Val His Pro Lys Gly 
705                 710                 715                 720 


Pro Lys Ser Leu Leu Ser Leu Glu Leu Lys Asp Asp Arg Pro Ala Arg 
                725                 730                 735     


Asp Met Trp Val Met Glu Thr Gly Leu Leu Leu Pro Arg Ala Thr Ala 
            740                 745                 750         


Gln Asp Ala Gly Lys Tyr Tyr Cys His Arg Gly Asn Leu Thr Met Ser 
        755                 760                 765             


Phe His Leu Glu Ile Thr Ala Arg Pro Val Leu Trp His Trp Leu Leu 
    770                 775                 780                 


Arg Thr Gly Gly Trp Lys Val Ser Ala Val Thr Leu Ala Tyr Leu Ile 
785                 790                 795                 800 


Phe Cys Leu Cys Ser Leu Val Gly Ile Leu His Leu Gln Arg Ala Leu 
                805                 810                 815     


Val Leu Arg Arg Lys Arg Lys Arg Met Thr Asp Pro Thr Arg Arg Phe 
            820                 825                 830         


<210> 18
<211> 2499
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 18
atggattgga tatggcgaat cttgttcctc gtcggtgccg cgaccggcgc tcactctgag       60

gtgcaactta aagagagtgg ccctggtctg gtggctcctg gtggaagctt gtctatcacg      120

tgtacagtat ccggatttag cttgacagac agttcaatca attgggtacg ccaacctccg      180

ggtaaaggtc tggagtggct cggaatgata tggggtgacg gtcggataga ttacgctgat      240

gcattgaaat ctaggctcag catatctaag gactctagca agagtcaggt ttttctggag      300

atgacgagtc tccgcacgga cgacaccgca acctactatt gtgccaggga tggctatttt      360

ccctatgcga tggacttctg gggccaagga acgagtgtca ccgtcagttc aggaggtggc      420

ggctctggag gtggaggcag tgggggcggt ggctctgaca ttgtgttgac ccaaagccca      480

gcctccttgg cggttagcct tggacagagg gcaacaatct cttgtcgggc cagcgagtcc      540

gtggacagct acggacagtc atatatgcat tggtaccagc agaaggcggg tcaacccccc      600

aagctcctca tatacttggc ttctaatttg gagagtgggg ttcctgcgag attttccgga      660

tctggttcta ggactgactt cacgttgacg atagatcccg tacaggcaga agacgcagca      720

acctactact gccaacaaaa tgcggaggac tcaagaacat ttgggggcgg taccaagctt      780

gaaattaagg atctcgagcc caaatcttgt gacaaaactc acacatgccc accgtgcccg      840

gatcccaaat tttgggtgct ggtggtggtt ggtggagtcc tggcttgcta tagcttgcta      900

gtaacagtgg cctttattat tttctgggtg gctgctggcg gacctggcgc cggatctgct      960

gctcctgtgt ctagcacaag cagcctgcct ctggccgccc tgaacatgag agtgcggaga     1020

aggctgagcc tgttcctgaa cgtgcggaca caggtggccg ccgattggac agccctggcc     1080

gaggaaatgg acttcgagta cctggaaatc cggcagctgg aaacccaggc cgaccctaca     1140

ggcagactgc tggatgcttg gcagggcaga ccaggcgctt ctgtgggaag gctgctggaa     1200

ctgctgacca agctgggcag ggacgacgtg ctgctggaac tgggccctag catcgaagag     1260

gactgccaga agtacatcct gaagcagcag caggaagagg ccgagaagcc tctgcaggtg     1320

gcagccgtgg atagcagcgt gccaagaaca gccgagctgg ccggcatcac caccctggat     1380

gatcctctgg gccacatgcc cgagagattc gacgccttca tctgctactg ccccagcgac     1440

atcgagggca gaggcagcct gctgacatgt ggcgacgtgg aagagaaccc aggccccatg     1500

cctcccccca gactgctgtt cttcctgctg ttcctgaccc ctatggaagt gcggcccgag     1560

gaacccctgg tcgtgaaagt ggaagagggc gacaacgccg tgctgcagtg tctgaagggc     1620

acctccgatg gccctaccca gcagctgacc tggtccagag agagccccct gaagcccttc     1680

ctgaagctgt ctctgggcct gcctggcctg ggcatccata tgaggccact ggccatctgg     1740

ctgttcatct tcaacgtgtc ccagcagatg ggaggcttct acctgtgcca gcctggccca     1800

ccttctgaga aggcttggca gcctggctgg accgtgaacg tggaaggatc tggcgagctg     1860

ttccggtgga acgtgtccga tctgggcggc ctgggatgcg gcctgaagaa cagatctagc     1920

gagggcccca gcagccccag cggcaaactg atgagcccca agctgtacgt gtgggccaag     1980

gacagacccg agatttggga gggcgagccc ccttgcctgc cccctagaga tagcctgaac     2040

cagagcctga gccaggacct gacaatggcc cctggcagca cactgtggct gagctgtggc     2100

gtgccacccg actctgtgtc tagaggccct ctgagctgga cccacgtgca ccctaagggc     2160

cctaagagcc tgctgtccct ggaactgaag gacgacaggc ccgccagaga tatgtgggtc     2220

atggaaaccg gcctgctgct gcctagagcc acagcccagg atgccggcaa gtactactgc     2280

cacagaggca acctgaccat gagcttccac ctggaaatca ccgccagacc cgtgctgtgg     2340

cactggctgc tgagaaccgg cggatggaaa gtgtccgccg tgactctggc ctacctgatc     2400

ttctgcctgt gctccctcgt gggcatcctg catctgcaga gggctctggt gctgcggcgg     2460

aagcggaaga gaatgaccga ccctacccgg cggttctaa                            2499


<210> 19
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp 
            20              


<210> 20
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 20
atgcaaatac cgcaggctcc gtggccagta gtatgggcag tcctccagct tggctggaga       60

cctggttgg                                                               69


<210> 21
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe Val Leu Asn Trp Tyr Arg Met Ser 
        35                  40                  45              


Pro Ser Asn Gln Thr Asp Lys Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Leu Cys Gly Ala Ile Ser Leu Ala Pro Lys Ala Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Gly Ser 
    130                 


<210> 22
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 22
ttcttggaca gtcctgatcg accttggaat cctccaacat tctcccccgc tttgctggtt       60

gtgacggaag gcgacaatgc tacatttacc tgcagtttct ctaataccag cgaatctttt      120

gtactgaatt ggtaccgcat gagccctagc aaccagaccg acaaattggc ggcgtttccg      180

gaagatcgaa gccaaccagg acaagattgc cgatttagag ttactcaact gcccaacgga      240

cgcgactttc atatgtcagt agtacgcgcg aggaggaatg atagtggaac atatctgtgt      300

ggagccatta gcctggcccc taaagcgcaa attaaagaat ctctgcgggc agagctgcga      360

gttacagagc gcagagcaga ggtcccaacc gcacacggat cc                         402


<210> 23
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 23
Cys Pro Ser Pro Leu Phe Pro Gly Pro Ser Lys Pro 
1               5                   10          


<210> 24
<211> 36
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 24
tgcccaagtc ctttgtttcc gggtcctagc aagccg                                 36


<210> 25
<211> 81
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
ttctgggtcc tcgttgtcgt aggaggagtg cttgcgtgct atagtctcct tgtaacggtt       60

gctttcatta tcttttgggt a                                                 81


<210> 26
<211> 513
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 26
gcggctggag ggccaggagc tggctctgcc gcgccggtgt cttccaccag ttcactgcct       60

ttggcggctc ttaacatgcg ggtcaggcga agattgagtt tgtttctgaa tgttaggact      120

caagtagctg ccgactggac ggcccttgcg gaagaaatgg acttcgagta tctagagatt      180

cgccaacttg aaacccaggc agatcctaca ggcagactcc tcgatgcgtg gcagggtcgg      240

cctggagcat ctgtgggaag gttgctggaa ctgttgacta aacttggtcg agatgacgta      300

ctgctggaat tgggtccaag catcgaagaa gattgtcaaa aatacatcct caagcagcaa      360

caagaggaag cagagaaacc attgcaagta gcggcagtag actctagcgt accgcgcact      420

gctgagcttg ctggaatcac gacccttgac gatcctctcg ggcatatgcc agagcggttc      480

gacgcattca tatgttattg tccaagcgat atc                                   513


<210> 27
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 27
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe Val 
    50                  55                  60                  


Leu Asn Trp Tyr Arg Met Ser Pro Ser Asn Gln Thr Asp Lys Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Leu Cys Gly Ala Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ala Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Gly Ser Cys Pro Ser 
145                 150                 155                 160 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Leu Glu Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala 
        195                 200                 205             


Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met 
    210                 215                 220                 


Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val 
225                 230                 235                 240 


Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu 
                245                 250                 255     


Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu 
            260                 265                 270         


Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu 
        275                 280                 285             


Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro 
    290                 295                 300                 


Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu 
305                 310                 315                 320 


Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro 
                325                 330                 335     


Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
            340                 345                 350         


His Met Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp 
        355                 360                 365             


Ile 
    


<210> 28
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 28
atgcaaatac cgcaggctcc gtggccagta gtatgggcag tcctccagct tggctggaga       60

cctggttggt tcttggacag tcctgatcga ccttggaatc ctccaacatt ctcccccgct      120

ttgctggttg tgacggaagg cgacaatgct acatttacct gcagtttctc taataccagc      180

gaatcttttg tactgaattg gtaccgcatg agccctagca accagaccga caaattggcg      240

gcgtttccgg aagatcgaag ccaaccagga caagattgcc gatttagagt tactcaactg      300

cccaacggac gcgactttca tatgtcagta gtacgcgcga ggaggaatga tagtggaaca      360

tatctgtgtg gagccattag cctggcccct aaagcgcaaa ttaaagaatc tctgcgggca      420

gagctgcgag ttacagagcg cagagcagag gtcccaaccg cacacggatc ctgcccaagt      480

cctttgtttc cgggtcctag caagccgttc tgggtcctcg ttgtcgtagg aggagtgctt      540

gcgtgctata gtctccttgt aacggttgct ttcattatct tttgggtact cgaggcggct      600

ggagggccag gagctggctc tgccgcgccg gtgtcttcca ccagttcact gcctttggcg      660

gctcttaaca tgcgggtcag gcgaagattg agtttgtttc tgaatgttag gactcaagta      720

gctgccgact ggacggccct tgcggaagaa atggacttcg agtatctaga gattcgccaa      780

cttgaaaccc aggcagatcc tacaggcaga ctcctcgatg cgtggcaggg tcggcctgga      840

gcatctgtgg gaaggttgct ggaactgttg actaaacttg gtcgagatga cgtactgctg      900

gaattgggtc caagcatcga agaagattgt caaaaataca tcctcaagca gcaacaagag      960

gaagcagaga aaccattgca agtagcggca gtagactcta gcgtaccgcg cactgctgag     1020

cttgctggaa tcacgaccct tgacgatcct ctcgggcata tgccagagcg gttcgacgca     1080

ttcatatgtt attgtccaag cgatatctaa                                      1110


<210> 29
<211> 69
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 29
atgcagatac cgcaggcccc ctggccagta gtctgggcgg ttctccaact tggatggcga       60

cctggttgg                                                               69


<210> 30
<211> 134
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 30
Phe Leu Asp Ser Pro Asp Arg Pro Trp Asn Pro Pro Thr Phe Ser Pro 
1               5                   10                  15      


Ala Leu Leu Val Val Thr Glu Gly Asp Asn Ala Thr Phe Thr Cys Ser 
            20                  25                  30          


Phe Ser Asn Thr Ser Glu Ser Phe His Val Val Trp His Arg Glu Ser 
        35                  40                  45              


Pro Ser Gly Gln Thr Asp Thr Leu Ala Ala Phe Pro Glu Asp Arg Ser 
    50                  55                  60                  


Gln Pro Gly Gln Asp Cys Arg Phe Arg Val Thr Gln Leu Pro Asn Gly 
65                  70                  75                  80  


Arg Asp Phe His Met Ser Val Val Arg Ala Arg Arg Asn Asp Ser Gly 
                85                  90                  95      


Thr Tyr Val Cys Gly Val Ile Ser Leu Ala Pro Lys Ile Gln Ile Lys 
            100                 105                 110         


Glu Ser Leu Arg Ala Glu Leu Arg Val Thr Glu Arg Arg Ala Glu Val 
        115                 120                 125             


Pro Thr Ala His Gly Ser 
    130                 


<210> 31
<211> 402
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 31
ttcctcgatt cacccgatcg accctggaac ccaccaacat tctctccggc gttgttggtg       60

gtgactgagg gcgacaatgc gacctttacg tgcagcttct caaatacatc tgaaagtttc      120

catgttgtct ggcacagaga gtccccttct gggcagactg atacgctcgc cgctttccct      180

gaggatagga gccagcctgg ccaagactgc cggttccgcg ttacacagct cccgaatggc      240

cgcgactttc acatgagcgt cgttcgagct cggcgaaacg atagtggtac atacgtctgt      300

ggtgtcatct cccttgcccc aaaaatccag atcaaggaat cccttcgcgc cgaacttaga      360

gtgactgaac gacgggctga ggtgccaact gcccacggat cc                         402


<210> 32
<211> 369
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 32
Met Gln Ile Pro Gln Ala Pro Trp Pro Val Val Trp Ala Val Leu Gln 
1               5                   10                  15      


Leu Gly Trp Arg Pro Gly Trp Phe Leu Asp Ser Pro Asp Arg Pro Trp 
            20                  25                  30          


Asn Pro Pro Thr Phe Ser Pro Ala Leu Leu Val Val Thr Glu Gly Asp 
        35                  40                  45              


Asn Ala Thr Phe Thr Cys Ser Phe Ser Asn Thr Ser Glu Ser Phe His 
    50                  55                  60                  


Val Val Trp His Arg Glu Ser Pro Ser Gly Gln Thr Asp Thr Leu Ala 
65                  70                  75                  80  


Ala Phe Pro Glu Asp Arg Ser Gln Pro Gly Gln Asp Cys Arg Phe Arg 
                85                  90                  95      


Val Thr Gln Leu Pro Asn Gly Arg Asp Phe His Met Ser Val Val Arg 
            100                 105                 110         


Ala Arg Arg Asn Asp Ser Gly Thr Tyr Val Cys Gly Val Ile Ser Leu 
        115                 120                 125             


Ala Pro Lys Ile Gln Ile Lys Glu Ser Leu Arg Ala Glu Leu Arg Val 
    130                 135                 140                 


Thr Glu Arg Arg Ala Glu Val Pro Thr Ala His Gly Ser Cys Pro Ser 
145                 150                 155                 160 


Pro Leu Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val 
                165                 170                 175     


Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile 
            180                 185                 190         


Ile Phe Trp Val Leu Glu Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala 
        195                 200                 205             


Ala Pro Val Ser Ser Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met 
    210                 215                 220                 


Arg Val Arg Arg Arg Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val 
225                 230                 235                 240 


Ala Ala Asp Trp Thr Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu 
                245                 250                 255     


Glu Ile Arg Gln Leu Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu 
            260                 265                 270         


Asp Ala Trp Gln Gly Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu 
        275                 280                 285             


Leu Leu Thr Lys Leu Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro 
    290                 295                 300                 


Ser Ile Glu Glu Asp Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu 
305                 310                 315                 320 


Glu Ala Glu Lys Pro Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro 
                325                 330                 335     


Arg Thr Ala Glu Leu Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly 
            340                 345                 350         


His Met Pro Glu Arg Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp 
        355                 360                 365             


Ile 
    


<210> 33
<211> 1110
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 33
atgcagatac cgcaggcccc ctggccagta gtctgggcgg ttctccaact tggatggcga       60

cctggttggt tcctcgattc acccgatcga ccctggaacc caccaacatt ctctccggcg      120

ttgttggtgg tgactgaggg cgacaatgcg acctttacgt gcagcttctc aaatacatct      180

gaaagtttcc atgttgtctg gcacagagag tccccttctg ggcagactga tacgctcgcc      240

gctttccctg aggataggag ccagcctggc caagactgcc ggttccgcgt tacacagctc      300

ccgaatggcc gcgactttca catgagcgtc gttcgagctc ggcgaaacga tagtggtaca      360

tacgtctgtg gtgtcatctc ccttgcccca aaaatccaga tcaaggaatc ccttcgcgcc      420

gaacttagag tgactgaacg acgggctgag gtgccaactg cccacggatc ctgcccaagt      480

cctttgtttc cgggtcctag caagccgttc tgggtcctcg ttgtcgtagg aggagtgctt      540

gcgtgctata gtctccttgt aacggttgct ttcattatct tttgggtact cgaggcggct      600

ggagggccag gagctggctc tgccgcgccg gtgtcttcca ccagttcact gcctttggcg      660

gctcttaaca tgcgggtcag gcgaagattg agtttgtttc tgaatgttag gactcaagta      720

gctgccgact ggacggccct tgcggaagaa atggacttcg agtatctaga gattcgccaa      780

cttgaaaccc aggcagatcc tacaggcaga ctcctcgatg cgtggcaggg tcggcctgga      840

gcatctgtgg gaaggttgct ggaactgttg actaaacttg gtcgagatga cgtactgctg      900

gaattgggtc caagcatcga agaagattgt caaaaataca tcctcaagca gcaacaagag      960

gaagcagaga aaccattgca agtagcggca gtagactcta gcgtaccgcg cactgctgag     1020

cttgctggaa tcacgaccct tgacgatcct ctcgggcata tgccagagcg gttcgacgca     1080

ttcatatgtt attgtccaag cgatatctaa                                      1110


<210> 34
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Gly Ser Gly Glu Gly Arg Gly Ser Leu Leu Thr Cys Gly Asp Val Glu 
1               5                   10                  15      


Glu Asn Pro Gly Pro 
            20      


<210> 35
<211> 63
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 35
Gly Ser Gly Ser Arg Val Thr Glu Leu Leu Tyr Arg Met Lys Arg Ala 
1               5                   10                  15      


Glu Thr Tyr Cys Pro Arg Pro Leu Leu Ala Ile His Pro Thr Glu Ala 
            20                  25                  30          


Arg His Lys Gln Lys Ile Val Ala Pro Val Lys Gln Leu Leu Asn Phe 
        35                  40                  45              


Asp Leu Leu Lys Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro 
    50                  55                  60              


<210> 36
<211> 19
<212> PRT
<213> Amphimedon sp.

<400> 36
Leu Leu Cys Phe Leu Leu Leu Leu Leu Ser Gly Asp Val Glu Leu Asn 
1               5                   10                  15      


Pro Gly Pro 
            


<210> 37
<211> 20
<212> PRT
<213> Amphimedon sp.

<400> 37
His His Phe Met Phe Leu Leu Leu Leu Leu Ala Gly Asp Ile Glu Leu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 38
<211> 20
<212> PRT
<213> Saccoglossus kowalevskii

<400> 38
Trp Phe Leu Val Leu Leu Ser Phe Ile Leu Ser Gly Asp Ile Glu Val 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 39
<211> 20
<212> PRT
<213> Branchiostoma floridae

<400> 39
Lys Asn Cys Ala Met Tyr Met Leu Leu Leu Ser Gly Asp Val Glu Thr 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 40
<211> 20
<212> PRT
<213> Branchiostoma floridae

<400> 40
Met Val Ile Ser Gln Leu Met Leu Lys Leu Ala Gly Asp Val Glu Glu 
1               5                   10                  15      


Asn Pro Gly Pro 
            20  


<210> 41
<211> 22
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gly Ser Gly Ala Thr Asn Phe Ser Leu Leu Lys Gln Ala Gly Asp Val 
1               5                   10                  15      


Glu Glu Asn Pro Gly Pro 
            20          


<210> 42
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Gly Ser Gly Gln Cys Thr Asn Tyr Ala Leu Leu Lys Leu Ala Gly Asp 
1               5                   10                  15      


Val Glu Ser Asn Pro Gly Pro 
            20              


<210> 43
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (2)..(2)
<223> Any amino acid

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any amino acid

<400> 43
Asp Xaa Glu Xaa Asn Pro Gly Pro 
1               5               


<210> 44
<211> 296
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 44
Met Ala Ala Gly Gly Pro Gly Ala Gly Ser Ala Ala Pro Val Ser Ser 
1               5                   10                  15      


Thr Ser Ser Leu Pro Leu Ala Ala Leu Asn Met Arg Val Arg Arg Arg 
            20                  25                  30          


Leu Ser Leu Phe Leu Asn Val Arg Thr Gln Val Ala Ala Asp Trp Thr 
        35                  40                  45              


Ala Leu Ala Glu Glu Met Asp Phe Glu Tyr Leu Glu Ile Arg Gln Leu 
    50                  55                  60                  


Glu Thr Gln Ala Asp Pro Thr Gly Arg Leu Leu Asp Ala Trp Gln Gly 
65                  70                  75                  80  


Arg Pro Gly Ala Ser Val Gly Arg Leu Leu Glu Leu Leu Thr Lys Leu 
                85                  90                  95      


Gly Arg Asp Asp Val Leu Leu Glu Leu Gly Pro Ser Ile Glu Glu Asp 
            100                 105                 110         


Cys Gln Lys Tyr Ile Leu Lys Gln Gln Gln Glu Glu Ala Glu Lys Pro 
        115                 120                 125             


Leu Gln Val Ala Ala Val Asp Ser Ser Val Pro Arg Thr Ala Glu Leu 
    130                 135                 140                 


Ala Gly Ile Thr Thr Leu Asp Asp Pro Leu Gly His Met Pro Glu Arg 
145                 150                 155                 160 


Phe Asp Ala Phe Ile Cys Tyr Cys Pro Ser Asp Ile Gln Phe Val Gln 
                165                 170                 175     


Glu Met Ile Arg Gln Leu Glu Gln Thr Asn Tyr Arg Leu Lys Leu Cys 
            180                 185                 190         


Val Ser Asp Arg Asp Val Leu Pro Gly Thr Cys Val Trp Ser Ile Ala 
        195                 200                 205             


Ser Glu Leu Ile Glu Lys Arg Cys Arg Arg Met Val Val Val Val Ser 
    210                 215                 220                 


Asp Asp Tyr Leu Gln Ser Lys Glu Cys Asp Phe Gln Thr Lys Phe Ala 
225                 230                 235                 240 


Leu Ser Leu Ser Pro Gly Ala His Gln Lys Arg Leu Ile Pro Ile Lys 
                245                 250                 255     


Tyr Lys Ala Met Lys Lys Glu Phe Pro Ser Ile Leu Arg Phe Ile Thr 
            260                 265                 270         


Val Cys Asp Tyr Thr Asn Pro Cys Thr Lys Ser Trp Phe Trp Thr Arg 
        275                 280                 285             


Leu Ala Lys Ala Leu Ser Leu Pro 
    290                 295     


<210> 45
<211> 888
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 45
atggcggctg gagggccagg agctggctct gccgcgccgg tgtcttccac cagttcactg       60

cctttggcgg ctcttaacat gcgggtcagg cgaagattga gtttgtttct gaatgttagg      120

actcaagtag ctgccgactg gacggccctt gcggaagaaa tggacttcga gtatctagag      180

attcgccaac ttgaaaccca ggcagatcct acaggcagac tcctcgatgc gtggcagggt      240

cggcctggag catctgtggg aaggttgctg gaactgttga ctaaacttgg tcgagatgac      300

gtactgctgg aattgggtcc aagcatcgaa gaagattgtc aaaaatacat cctcaagcag      360

caacaagagg aagcagagaa accattgcaa gtagcggcag tagactctag cgtaccgcgc      420

actgctgagc ttgctggaat cacgaccctt gacgatcctc tcgggcatat gccagagcgg      480

ttcgacgcat tcatatgtta ttgtccaagc gatatccagt ttgtgcagga aatgattcga      540

cagcttgaac agaccaatta caggctgaaa ctgtgcgtgt cagaccgaga tgtgctgcca      600

ggaacttgcg tatggtctat cgcttccgaa ctgatcgaga aacgatgccg gcgcatggta      660

gtcgtcgtaa gtgacgatta tttgcaatcc aaagaatgtg attttcagac taaattcgca      720

ttgagtctgt ccccaggtgc ccatcaaaaa cggctcatac ccattaagta taaggcgatg      780

aagaaagaat ttccctccat cctcagattc ataactgtct gtgactatac caatccttgc      840

actaagagtt ggttttggac ccgattggca aaagcccttt ccctgccg                   888


