                               SEQUENCE LISTING

<110> MADDON ADVISORS LLC

<120> TMPRSS2-TARGETED COMPOSITIONS AND METHODS FOR TREATING COVID-19

<130> MADDON-5PCT

<140> PCT/US2021/026787
<141> 2021-04-12

<150> 63/029,772
<151> 2020-05-26

<150> 63/029,765
<151> 2020-05-26

<150> 63/028,639
<151> 2020-05-22

<150> 63/028,627
<151> 2020-05-22

<150> 63/017,159
<151> 2020-04-29

<150> 63/008,988
<151> 2020-04-13

<160> 9    

<170> PatentIn version 3.5

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Lys Gln Leu Arg 
1               


<210> 2
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Glx Gln Arg Arg Glx Lys 
1               5       


<210> 3
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 3
His His His His His His 
1               5       


<210> 4
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Val Arg Pro Arg 
1               


<210> 5
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Arg Lys Arg Arg 
1               


<210> 6
<211> 2479
<212> DNA
<213> Homo sapiens

<400> 6
gtcatattga acattccaga tacctatcat tactcgatgc tgttgataac agcaagatgg       60

ctttgaactc agggtcacca ccagctattg gaccttacta tgaaaaccat ggataccaac      120

cggaaaaccc ctatcccgca cagcccactg tggtccccac tgtctacgag gtgcatccgg      180

ctcagtacta cccgtccccc gtgccccagt acgccccgag ggtcctgacg caggcttcca      240

accccgtcgt ctgcacgcag cccaaatccc catccgggac agtgtgcacc tcaaagacta      300

agaaagcact gtgcatcacc ttgaccctgg ggaccttcct cgtgggagct gcgctggccg      360

ctggcctact ctggaagttc atgggcagca agtgctccaa ctctgggata gagtgcgact      420

cctcaggtac ctgcatcaac ccctctaact ggtgtgatgg cgtgtcacac tgccccggcg      480

gggaggacga gaatcggtgt gttcgcctct acggaccaaa cttcatcctt cagatgtact      540

catctcagag gaagtcctgg caccctgtgt gccaagacga ctggaacgag aactacgggc      600

gggcggcctg cagggacatg ggctataaga ataattttta ctctagccaa ggaatagtgg      660

atgacagcgg atccaccagc tttatgaaac tgaacacaag tgccggcaat gtcgatatct      720

ataaaaaact gtaccacagt gatgcctgtt cttcaaaagc agtggtttct ttacgctgtt      780

tagcctgcgg ggtcaacttg aactcaagcc gccagagcag gatcgtgggc ggtgagagcg      840

cgctcccggg ggcctggccc tggcaggtca gcctgcacgt ccagaacgtc cacgtgtgcg      900

gaggctccat catcaccccc gagtggatcg tgacagccgc ccactgcgtg gaaaaacctc      960

ttaacaatcc atggcattgg acggcatttg cggggatttt gagacaatct ttcatgttct     1020

atggagccgg ataccaagta caaaaagtga tttctcatcc aaattatgac tccaagacca     1080

agaacaatga cattgcgctg atgaagctgc agaagcctct gactttcaac gacctagtga     1140

aaccagtgtg tctgcccaac ccaggcatga tgctgcagcc agaacagctc tgctggattt     1200

ccgggtgggg ggccaccgag gagaaaggga agacctcaga agtgctgaac gctgccaagg     1260

tgcttctcat tgagacacag agatgcaaca gcagatatgt ctatgacaac ctgatcacac     1320

cagccatgat ctgtgccggc ttcctgcagg ggaacgtcga ttcttgccag ggtgacagtg     1380

gagggcctct ggtcacttcg aacaacaata tctggtggct gataggggat acaagctggg     1440

gttctggctg tgccaaagct tacagaccag gagtgtacgg gaatgtgatg gtattcacgg     1500

actggattta tcgacaaatg aaggcaaacg gctaatccac atggtcttcg tccttgacgt     1560

cgttttacaa gaaaacaatg gggctggttt tgcttccccg tgcatgattt actcttagag     1620

atgattcaga ggtcacttca tttttattaa acagtgaact tgtctggctt tggcactctc     1680

tgccatactg tgcaggctgc agtggctccc ctgcccagcc tgctctccct aaccccttgt     1740

ccgcaagggg tgatggccgg ctggttgtgg gcactggcgg tcaattgtgg aaggaagagg     1800

gttggaggct gcccccattg agatcttcct gctgagtcct ttccaggggc caattttgga     1860

tgagcatgga gctgtcactt ctcagctgct ggatgacttg agatgaaaaa ggagagacat     1920

ggaaagggag acagccaggt ggcacctgca gcggctgccc tctggggcca cttggtagtg     1980

tccccagcct acttcacaag gggattttgc tgatgggttc ttagagcctt agcagccctg     2040

gatggtggcc agaaataaag ggaccagccc ttcatgggtg gtgacgtggt agtcacttgt     2100

aaggggaaca gaaacatttt tgttcttatg gggtgagaat atagacagtg cccttggtgc     2160

gagggaagca attgaaaagg aacttgccct gagcactcct ggtgcaggtc tccacctgca     2220

cattgggtgg ggctcctggg agggagactc agccttcctc ctcatcctcc ctgaccctgc     2280

tcctagcacc ctggagagtg aatgcccctt ggtccctggc agggcgccaa gtttggcacc     2340

atgtcggcct cttcaggcct gatagtcatt ggaaattgag gtccatgggg gaaatcaagg     2400

atgctcagtt taaggtacac tgtttccatg ttatgtttct acacattgat ggtggtgacc     2460

ctgagttcaa agccatctt                                                  2479


<210> 7
<211> 492
<212> PRT
<213> Homo sapiens

<400> 7
Met Ala Leu Asn Ser Gly Ser Pro Pro Ala Ile Gly Pro Tyr Tyr Glu 
1               5                   10                  15      


Asn His Gly Tyr Gln Pro Glu Asn Pro Tyr Pro Ala Gln Pro Thr Val 
            20                  25                  30          


Val Pro Thr Val Tyr Glu Val His Pro Ala Gln Tyr Tyr Pro Ser Pro 
        35                  40                  45              


Val Pro Gln Tyr Ala Pro Arg Val Leu Thr Gln Ala Ser Asn Pro Val 
    50                  55                  60                  


Val Cys Thr Gln Pro Lys Ser Pro Ser Gly Thr Val Cys Thr Ser Lys 
65                  70                  75                  80  


Thr Lys Lys Ala Leu Cys Ile Thr Leu Thr Leu Gly Thr Phe Leu Val 
                85                  90                  95      


Gly Ala Ala Leu Ala Ala Gly Leu Leu Trp Lys Phe Met Gly Ser Lys 
            100                 105                 110         


Cys Ser Asn Ser Gly Ile Glu Cys Asp Ser Ser Gly Thr Cys Ile Asn 
        115                 120                 125             


Pro Ser Asn Trp Cys Asp Gly Val Ser His Cys Pro Gly Gly Glu Asp 
    130                 135                 140                 


Glu Asn Arg Cys Val Arg Leu Tyr Gly Pro Asn Phe Ile Leu Gln Met 
145                 150                 155                 160 


Tyr Ser Ser Gln Arg Lys Ser Trp His Pro Val Cys Gln Asp Asp Trp 
                165                 170                 175     


Asn Glu Asn Tyr Gly Arg Ala Ala Cys Arg Asp Met Gly Tyr Lys Asn 
            180                 185                 190         


Asn Phe Tyr Ser Ser Gln Gly Ile Val Asp Asp Ser Gly Ser Thr Ser 
        195                 200                 205             


Phe Met Lys Leu Asn Thr Ser Ala Gly Asn Val Asp Ile Tyr Lys Lys 
    210                 215                 220                 


Leu Tyr His Ser Asp Ala Cys Ser Ser Lys Ala Val Val Ser Leu Arg 
225                 230                 235                 240 


Cys Leu Ala Cys Gly Val Asn Leu Asn Ser Ser Arg Gln Ser Arg Ile 
                245                 250                 255     


Val Gly Gly Glu Ser Ala Leu Pro Gly Ala Trp Pro Trp Gln Val Ser 
            260                 265                 270         


Leu His Val Gln Asn Val His Val Cys Gly Gly Ser Ile Ile Thr Pro 
        275                 280                 285             


Glu Trp Ile Val Thr Ala Ala His Cys Val Glu Lys Pro Leu Asn Asn 
    290                 295                 300                 


Pro Trp His Trp Thr Ala Phe Ala Gly Ile Leu Arg Gln Ser Phe Met 
305                 310                 315                 320 


Phe Tyr Gly Ala Gly Tyr Gln Val Gln Lys Val Ile Ser His Pro Asn 
                325                 330                 335     


Tyr Asp Ser Lys Thr Lys Asn Asn Asp Ile Ala Leu Met Lys Leu Gln 
            340                 345                 350         


Lys Pro Leu Thr Phe Asn Asp Leu Val Lys Pro Val Cys Leu Pro Asn 
        355                 360                 365             


Pro Gly Met Met Leu Gln Pro Glu Gln Leu Cys Trp Ile Ser Gly Trp 
    370                 375                 380                 


Gly Ala Thr Glu Glu Lys Gly Lys Thr Ser Glu Val Leu Asn Ala Ala 
385                 390                 395                 400 


Lys Val Leu Leu Ile Glu Thr Gln Arg Cys Asn Ser Arg Tyr Val Tyr 
                405                 410                 415     


Asp Asn Leu Ile Thr Pro Ala Met Ile Cys Ala Gly Phe Leu Gln Gly 
            420                 425                 430         


Asn Val Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Thr Ser 
        435                 440                 445             


Asn Asn Asn Ile Trp Trp Leu Ile Gly Asp Thr Ser Trp Gly Ser Gly 
    450                 455                 460                 


Cys Ala Lys Ala Tyr Arg Pro Gly Val Tyr Gly Asn Val Met Val Phe 
465                 470                 475                 480 


Thr Asp Trp Ile Tyr Arg Gln Met Lys Ala Asn Gly 
                485                 490         


<210> 8
<211> 3405
<212> DNA
<213> Homo sapiens

<400> 8
cgcccaaccc aagttcaaag gctgataaga gagaaaatct catgaggagg ttttagtcta       60

gggaaagtca ttcagtggat gtgatcttgg ctcacagggg acgatgtcaa gctcttcctg      120

gctccttctc agccttgttg ctgtaactgc tgctcagtcc accattgagg aacaggccaa      180

gacatttttg gacaagttta accacgaagc cgaagacctg ttctatcaaa gttcacttgc      240

ttcttggaat tataacacca atattactga agagaatgtc caaaacatga ataatgctgg      300

ggacaaatgg tctgcctttt taaaggaaca gtccacactt gcccaaatgt atccactaca      360

agaaattcag aatctcacag tcaagcttca gctgcaggct cttcagcaaa atgggtcttc      420

agtgctctca gaagacaaga gcaaacggtt gaacacaatt ctaaatacaa tgagcaccat      480

ctacagtact ggaaaagttt gtaacccaga taatccacaa gaatgcttat tacttgaacc      540

aggtttgaat gaaataatgg caaacagttt agactacaat gagaggctct gggcttggga      600

aagctggaga tctgaggtcg gcaagcagct gaggccatta tatgaagagt atgtggtctt      660

gaaaaatgag atggcaagag caaatcatta tgaggactat ggggattatt ggagaggaga      720

ctatgaagta aatggggtag atggctatga ctacagccgc ggccagttga ttgaagatgt      780

ggaacatacc tttgaagaga ttaaaccatt atatgaacat cttcatgcct atgtgagggc      840

aaagttgatg aatgcctatc cttcctatat cagtccaatt ggatgcctcc ctgctcattt      900

gcttggtgat atgtggggta gattttggac aaatctgtac tctttgacag ttccctttgg      960

acagaaacca aacatagatg ttactgatgc aatggtggac caggcctggg atgcacagag     1020

aatattcaag gaggccgaga agttctttgt atctgttggt cttcctaata tgactcaagg     1080

attctgggaa aattccatgc taacggaccc aggaaatgtt cagaaagcag tctgccatcc     1140

cacagcttgg gacctgggga agggcgactt caggatcctt atgtgcacaa aggtgacaat     1200

ggacgacttc ctgacagctc atcatgagat ggggcatatc cagtatgata tggcatatgc     1260

tgcacaacct tttctgctaa gaaatggagc taatgaagga ttccatgaag ctgttgggga     1320

aatcatgtca ctttctgcag ccacacctaa gcatttaaaa tccattggtc ttctgtcacc     1380

cgattttcaa gaagacaatg aaacagaaat aaacttcctg ctcaaacaag cactcacgat     1440

tgttgggact ctgccattta cttacatgtt agagaagtgg aggtggatgg tctttaaagg     1500

ggaaattccc aaagaccagt ggatgaaaaa gtggtgggag atgaagcgag agatagttgg     1560

ggtggtggaa cctgtgcccc atgatgaaac atactgtgac cccgcatctc tgttccatgt     1620

ttctaatgat tactcattca ttcgatatta cacaaggacc ctttaccaat tccagtttca     1680

agaagcactt tgtcaagcag ctaaacatga aggccctctg cacaaatgtg acatctcaaa     1740

ctctacagaa gctggacaga aactgttcaa tatgctgagg cttggaaaat cagaaccctg     1800

gaccctagca ttggaaaatg ttgtaggagc aaagaacatg aatgtaaggc cactgctcaa     1860

ctactttgag cccttattta cctggctgaa agaccagaac aagaattctt ttgtgggatg     1920

gagtaccgac tggagtccat atgcagacca aagcatcaaa gtgaggataa gcctaaaatc     1980

agctcttgga gataaagcat atgaatggaa cgacaatgaa atgtacctgt tccgatcatc     2040

tgttgcatat gctatgaggc agtacttttt aaaagtaaaa aatcagatga ttctttttgg     2100

ggaggaggat gtgcgagtgg ctaatttgaa accaagaatc tcctttaatt tctttgtcac     2160

tgcacctaaa aatgtgtctg atatcattcc tagaactgaa gttgaaaagg ccatcaggat     2220

gtcccggagc cgtatcaatg atgctttccg tctgaatgac aacagcctag agtttctggg     2280

gatacagcca acacttggac ctcctaacca gccccctgtt tccatatggc tgattgtttt     2340

tggagttgtg atgggagtga tagtggttgg cattgtcatc ctgatcttca ctgggatcag     2400

agatcggaag aagaaaaata aagcaagaag tggagaaaat ccttatgcct ccatcgatat     2460

tagcaaagga gaaaataatc caggattcca aaacactgat gatgttcaga cctcctttta     2520

gaaaaatcta tgtttttcct cttgaggtga ttttgttgta tgtaaatgtt aatttcatgg     2580

tatagaaaat ataagatgat aaagatatca ttaaatgtca aaactatgac tctgttcaga     2640

aaaaaaattg tccaaagaca acatggccaa ggagagagca tcttcattga cattgctttc     2700

agtatttatt tctgtctctg gatttgactt ctgttctgtt tcttaataag gattttgtat     2760

tagagtatat tagggaaagt gtgtatttgg tctcacaggc tgttcaggga taatctaaat     2820

gtaaatgtct gttgaatttc tgaagttgaa aacaaggata tatcattgga gcaagtgttg     2880

gatcttgtat ggaatatgga tggatcactt gtaaggacag tgcctgggaa ctggtgtagc     2940

tgcaaggatt gagaatggca tgcattagct cactttcatt taatccattg tcaaggatga     3000

catgctttct tcacagtaac tcagttcaag tactatggtg atttgcctac agtgatgttt     3060

ggaatcgatc atgctttctt caaggtgaca ggtctaaaga gagaagaatc cagggaacag     3120

gtagaggaca ttgctttttc acttccaagg tgcttgatca acatctccct gacaacacaa     3180

aactagagcc aggggcctcc gtgaactccc agagcatgcc tgatagaaac tcatttctac     3240

tgttctctaa ctgtggagtg aatggaaatt ccaactgtat gttcaccctc tgaagtgggt     3300

acccagtctc ttaaatcttt tgtatttgct cacagtgttt gagcagtgct gagcacaaag     3360

cagacactca ataaatgcta gatttacaca ctcaaaaaaa aaaaa                     3405


<210> 9
<211> 805
<212> PRT
<213> Homo sapiens

<400> 9
Met Ser Ser Ser Ser Trp Leu Leu Leu Ser Leu Val Ala Val Thr Ala 
1               5                   10                  15      


Ala Gln Ser Thr Ile Glu Glu Gln Ala Lys Thr Phe Leu Asp Lys Phe 
            20                  25                  30          


Asn His Glu Ala Glu Asp Leu Phe Tyr Gln Ser Ser Leu Ala Ser Trp 
        35                  40                  45              


Asn Tyr Asn Thr Asn Ile Thr Glu Glu Asn Val Gln Asn Met Asn Asn 
    50                  55                  60                  


Ala Gly Asp Lys Trp Ser Ala Phe Leu Lys Glu Gln Ser Thr Leu Ala 
65                  70                  75                  80  


Gln Met Tyr Pro Leu Gln Glu Ile Gln Asn Leu Thr Val Lys Leu Gln 
                85                  90                  95      


Leu Gln Ala Leu Gln Gln Asn Gly Ser Ser Val Leu Ser Glu Asp Lys 
            100                 105                 110         


Ser Lys Arg Leu Asn Thr Ile Leu Asn Thr Met Ser Thr Ile Tyr Ser 
        115                 120                 125             


Thr Gly Lys Val Cys Asn Pro Asp Asn Pro Gln Glu Cys Leu Leu Leu 
    130                 135                 140                 


Glu Pro Gly Leu Asn Glu Ile Met Ala Asn Ser Leu Asp Tyr Asn Glu 
145                 150                 155                 160 


Arg Leu Trp Ala Trp Glu Ser Trp Arg Ser Glu Val Gly Lys Gln Leu 
                165                 170                 175     


Arg Pro Leu Tyr Glu Glu Tyr Val Val Leu Lys Asn Glu Met Ala Arg 
            180                 185                 190         


Ala Asn His Tyr Glu Asp Tyr Gly Asp Tyr Trp Arg Gly Asp Tyr Glu 
        195                 200                 205             


Val Asn Gly Val Asp Gly Tyr Asp Tyr Ser Arg Gly Gln Leu Ile Glu 
    210                 215                 220                 


Asp Val Glu His Thr Phe Glu Glu Ile Lys Pro Leu Tyr Glu His Leu 
225                 230                 235                 240 


His Ala Tyr Val Arg Ala Lys Leu Met Asn Ala Tyr Pro Ser Tyr Ile 
                245                 250                 255     


Ser Pro Ile Gly Cys Leu Pro Ala His Leu Leu Gly Asp Met Trp Gly 
            260                 265                 270         


Arg Phe Trp Thr Asn Leu Tyr Ser Leu Thr Val Pro Phe Gly Gln Lys 
        275                 280                 285             


Pro Asn Ile Asp Val Thr Asp Ala Met Val Asp Gln Ala Trp Asp Ala 
    290                 295                 300                 


Gln Arg Ile Phe Lys Glu Ala Glu Lys Phe Phe Val Ser Val Gly Leu 
305                 310                 315                 320 


Pro Asn Met Thr Gln Gly Phe Trp Glu Asn Ser Met Leu Thr Asp Pro 
                325                 330                 335     


Gly Asn Val Gln Lys Ala Val Cys His Pro Thr Ala Trp Asp Leu Gly 
            340                 345                 350         


Lys Gly Asp Phe Arg Ile Leu Met Cys Thr Lys Val Thr Met Asp Asp 
        355                 360                 365             


Phe Leu Thr Ala His His Glu Met Gly His Ile Gln Tyr Asp Met Ala 
    370                 375                 380                 


Tyr Ala Ala Gln Pro Phe Leu Leu Arg Asn Gly Ala Asn Glu Gly Phe 
385                 390                 395                 400 


His Glu Ala Val Gly Glu Ile Met Ser Leu Ser Ala Ala Thr Pro Lys 
                405                 410                 415     


His Leu Lys Ser Ile Gly Leu Leu Ser Pro Asp Phe Gln Glu Asp Asn 
            420                 425                 430         


Glu Thr Glu Ile Asn Phe Leu Leu Lys Gln Ala Leu Thr Ile Val Gly 
        435                 440                 445             


Thr Leu Pro Phe Thr Tyr Met Leu Glu Lys Trp Arg Trp Met Val Phe 
    450                 455                 460                 


Lys Gly Glu Ile Pro Lys Asp Gln Trp Met Lys Lys Trp Trp Glu Met 
465                 470                 475                 480 


Lys Arg Glu Ile Val Gly Val Val Glu Pro Val Pro His Asp Glu Thr 
                485                 490                 495     


Tyr Cys Asp Pro Ala Ser Leu Phe His Val Ser Asn Asp Tyr Ser Phe 
            500                 505                 510         


Ile Arg Tyr Tyr Thr Arg Thr Leu Tyr Gln Phe Gln Phe Gln Glu Ala 
        515                 520                 525             


Leu Cys Gln Ala Ala Lys His Glu Gly Pro Leu His Lys Cys Asp Ile 
    530                 535                 540                 


Ser Asn Ser Thr Glu Ala Gly Gln Lys Leu Phe Asn Met Leu Arg Leu 
545                 550                 555                 560 


Gly Lys Ser Glu Pro Trp Thr Leu Ala Leu Glu Asn Val Val Gly Ala 
                565                 570                 575     


Lys Asn Met Asn Val Arg Pro Leu Leu Asn Tyr Phe Glu Pro Leu Phe 
            580                 585                 590         


Thr Trp Leu Lys Asp Gln Asn Lys Asn Ser Phe Val Gly Trp Ser Thr 
        595                 600                 605             


Asp Trp Ser Pro Tyr Ala Asp Gln Ser Ile Lys Val Arg Ile Ser Leu 
    610                 615                 620                 


Lys Ser Ala Leu Gly Asp Lys Ala Tyr Glu Trp Asn Asp Asn Glu Met 
625                 630                 635                 640 


Tyr Leu Phe Arg Ser Ser Val Ala Tyr Ala Met Arg Gln Tyr Phe Leu 
                645                 650                 655     


Lys Val Lys Asn Gln Met Ile Leu Phe Gly Glu Glu Asp Val Arg Val 
            660                 665                 670         


Ala Asn Leu Lys Pro Arg Ile Ser Phe Asn Phe Phe Val Thr Ala Pro 
        675                 680                 685             


Lys Asn Val Ser Asp Ile Ile Pro Arg Thr Glu Val Glu Lys Ala Ile 
    690                 695                 700                 


Arg Met Ser Arg Ser Arg Ile Asn Asp Ala Phe Arg Leu Asn Asp Asn 
705                 710                 715                 720 


Ser Leu Glu Phe Leu Gly Ile Gln Pro Thr Leu Gly Pro Pro Asn Gln 
                725                 730                 735     


Pro Pro Val Ser Ile Trp Leu Ile Val Phe Gly Val Val Met Gly Val 
            740                 745                 750         


Ile Val Val Gly Ile Val Ile Leu Ile Phe Thr Gly Ile Arg Asp Arg 
        755                 760                 765             


Lys Lys Lys Asn Lys Ala Arg Ser Gly Glu Asn Pro Tyr Ala Ser Ile 
    770                 775                 780                 


Asp Ile Ser Lys Gly Glu Asn Asn Pro Gly Phe Gln Asn Thr Asp Asp 
785                 790                 795                 800 


Val Gln Thr Ser Phe 
                805 





