                         SEQUENCE LISTING

<110>  Ramot at Tel-Aviv University Ltd.
       B.G. Negev Technologies and Applications Ltd., at 
       Ben-Gurion University
 
<120>  MONOCLONAL ANTIBODY AND USES THEREOF FOR THE TREATMENT AND 
       DIAGNOSIS OF MULTIDRUG-RESISTANT PATHOGENIC BACTERIAL INFECTIONS

<130>  2776242-JDB

<150>  US 63/010,919
<151>  2020-04-16

<150>  US 63/118,358
<151>  2020-11-25

<160>  49    

<170>  PatentIn version 3.5

<210>  1
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH Full Sequence

<400>  1
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc cactatgcca tgaactgggt ccgccaggct      120

ccagggaagg ggctggagtg ggtttcagcc attaatagta atggtgatag cacctactat      180

ccagacactg tgaaggaccg attcaccatc tccagagaca attccaagaa cacgctgtat      240

ctgcaaatga acagcctgag agccgaggac acggccgtgt attactgtgc gagagatcgg      300

cgagcagggt actttgacta ctggggccag ggcaccctgg tcacagtctc ctca            354


<210>  2
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH  Full Sequence

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Asn Gly Asp Ser Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Arg Ala Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  3
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH FR1

<400>  3
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctct                                                        75


<210>  4
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH FR1

<400>  4

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  5
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH1

<400>  5
ggattcacct ttagccacta tgcc                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH1

<400>  6

Gly Phe Thr Phe Ser His Tyr Ala 
1               5               


<210>  7
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH FR2

<400>  7
atgaactggg tccgccaggc tccagggaag gggctggagt gggtttcagc c                51


<210>  8
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH FR2

<400>  8

Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15      


Ala 
    


<210>  9
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH2

<400>  9
attaatagta atggtgatag cacc                                              24


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH2

<400>  10

Ile Asn Ser Asn Gly Asp Ser Thr 
1               5               


<210>  11
<211>  114
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH FR3

<400>  11
tactatccag acactgtgaa ggaccgattc accatctcca gagacaattc caagaacacg       60

ctgtatctgc aaatgaacag cctgagagcc gaggacacgg ccgtgtatta ctgt            114


<210>  12
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH FR3

<400>  12

Tyr Tyr Pro Asp Thr Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            20                  25                  30          


Thr Ala Val Tyr Tyr Cys 
        35              


<210>  13
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH3

<400>  13
gcgagagatc ggcgagcagg gtactttgac tactgg                                 36


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH CDRH3

<400>  14

Ala Arg Asp Arg Arg Ala Gly Tyr Phe Asp Tyr Trp 
1               5                   10          


<210>  15
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7-VH J Region

<400>  15
ggccagggca ccctggtcac agtctcctca                                        30


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7-VH J Region

<400>  16

Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
1               5                   10  


<210>  17
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL (lambda) Full Sequence

<400>  17
gatatcgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgctctg gaagcaggga caacatcggg aagaattatg tgtcctggta ccagcagctt      120

ccaggaacag cccccaaact cctcatttat aggaataatc agcggccctc aggggtccct      180

gaccggttct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctgcgg      240

tccgaggatg aggctgatta ttactgctca gcgtgggaca ccagcctcaa tgcttatgtc      300

ttcgggcctg gcacccagct caccgtcctc                                       330


<210>  18
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL (lambda) Full Sequence

<400>  18

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Asp Asn Ile Gly Lys Asn 
            20                  25                  30          


Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ala Trp Asp Thr Ser Leu 
                85                  90                  95      


Asn Ala Tyr Val Phe Gly Pro Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110 


<210>  19
<211>  75
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL FR1

<400>  19
gatatcgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc       60

tcctgctctg gaagc                                                        75


<210>  20
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL FR1

<400>  20

Asp Ile Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser 
            20                  25  


<210>  21
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL1

<400>  21
agggacaaca tcgggaagaa ttat                                              24


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL1

<400>  22

Arg Asp Asn Ile Gly Lys Asn Tyr 
1               5               


<210>  23
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL FR2

<400>  23
gtgtcctggt accagcagct tccaggaaca gcccccaaac tcctcattta t                51


<210>  24
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL FR2

<400>  24

Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  25
<211>  10
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL2


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  n is null

<400>  25
aggaataatn                                                              10


<210>  26
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL2


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is null

<400>  26

Arg Asn Asn Xaa 
1               


<210>  27
<211>  108
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL FR3

<400>  27
cagcggccct caggggtccc tgaccggttc tctggctcca agtctggcac ctcagcctcc       60

ctggccatca gtgggctgcg gtccgaggat gaggctgatt attactgc                   108


<210>  28
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL FR3

<400>  28

Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly 
1               5                   10                  15      


Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg Ser Glu Asp Glu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  29
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL3

<400>  29
tcagcgtggg acaccagcct caatgct                                           27


<210>  30
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL CDRL3

<400>  30

Ser Ala Trp Asp Thr Ser Leu Asn Ala 
1               5                   


<210>  31
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  B7- VL J Region

<400>  31
tatgtcttcg ggcctggcac ccagctcacc gtcctc                                 36


<210>  32
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  B7- VL J Region

<400>  32

Tyr Val Phe Gly Pro Gly Thr Gln Leu Thr Val Leu 
1               5                   10          


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #49

<400>  33

Cys Thr Ser Ala Gln Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp 
1               5                   10                  15      


Cys 
    


<210>  34
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #49-SC

<400>  34

Cys Ser Ser Glu Val Gln Ala Ala Lys Ala Asp Thr Glu Ala Gln Ala 
1               5                   10                  15      


Cys 
    


<210>  35
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #50

<400>  35

Cys Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp Ala Ala Gln Glu 
1               5                   10                  15      


Cys 
    


<210>  36
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #50-SC

<400>  36

Cys Asp Glu Ala Val Ala Gln Ala Ala Ala Glu Lys Glu Ala Gln Ser 
1               5                   10                  15      


Cys 
    


<210>  37
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #49+50

<400>  37

Cys Thr Ser Ala Gln Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp 
1               5                   10                  15      


Ala Ala Gln Glu Cys 
            20      


<210>  38
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE #78

<400>  38

Cys Thr Asp Leu Ile Asn Arg Met Gly Gln Ala Ala Arg Leu Ala Gly 
1               5                   10                  15      


Cys 
    


<210>  39
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  EPITOPE OF B7

<400>  39

Thr Ser Ala Gln Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp Ala 
1               5                   10                  15      


Ala Gln 
        


<210>  40
<211>  321
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  EspB, EPEC

Accession number: WP_001091991.1

<400>  40

Met Asn Thr Ile Asp Asn Asn Asn Ala Ala Ile Ala Val Asn Ser Val 
1               5                   10                  15      


Leu Ser Ser Thr Thr Asp Ser Thr Ser Ser Thr Thr Thr Ser Thr Ser 
            20                  25                  30          


Ser Ile Ser Ser Ser Leu Leu Thr Asp Gly Arg Val Asp Ile Ser Lys 
        35                  40                  45              


Leu Leu Leu Glu Val Gln Lys Leu Leu Arg Glu Met Val Thr Thr Leu 
    50                  55                  60                  


Gln Asp Tyr Leu Gln Lys Gln Leu Ala Gln Ser Tyr Asp Ile Gln Lys 
65                  70                  75                  80  


Ala Val Phe Glu Ser Gln Asn Lys Ala Ile Asp Glu Lys Lys Ala Gly 
                85                  90                  95      


Ala Thr Ala Ala Leu Ile Gly Gly Ala Ile Ser Ser Val Leu Gly Ile 
            100                 105                 110         


Leu Gly Ser Phe Ala Ala Ile Asn Ser Ala Thr Lys Gly Ala Ser Asp 
        115                 120                 125             


Val Ala Gln Gln Ala Ala Ser Thr Ser Ala Lys Ser Ile Gly Thr Val 
    130                 135                 140                 


Ser Glu Ala Ser Thr Lys Ala Leu Ala Lys Ala Ser Glu Gly Ile Ala 
145                 150                 155                 160 


Asp Ala Ala Asp Asp Ala Ala Gly Ala Met Gln Gln Thr Ile Ala Thr 
                165                 170                 175     


Ala Ala Lys Ala Ala Ser Arg Thr Ser Gly Ile Thr Asp Asp Val Ala 
            180                 185                 190         


Thr Ser Ala Gln Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp Ala 
        195                 200                 205             


Ala Gln Glu Leu Ala Gln Lys Ala Gly Leu Leu Ser Arg Phe Thr Ala 
    210                 215                 220                 


Ala Ala Gly Arg Ile Ser Gly Ser Thr Pro Phe Ile Val Val Thr Ser 
225                 230                 235                 240 


Leu Ala Glu Gly Thr Lys Thr Leu Pro Thr Thr Ile Ser Glu Ser Val 
                245                 250                 255     


Lys Ser Asn His Asp Ile Asn Glu Gln Arg Ala Lys Ser Val Glu Asn 
            260                 265                 270         


Leu Gln Ala Ser Asn Leu Asp Thr Tyr Lys Gln Asp Val Arg Arg Ala 
        275                 280                 285             


Gln Asp Asp Ile Ser Ser Arg Leu Arg Asp Met Thr Thr Thr Ala Arg 
    290                 295                 300                 


Asp Leu Thr Asp Leu Ile Asn Arg Met Gly Gln Ala Ala Arg Leu Ala 
305                 310                 315                 320 


Gly 
    


<210>  41
<211>  945
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<223>  EspB, EPEC

Accession number: AAB69980.1

<400>  41
atgaatacta ttgattatac taatcaagta atgacggtta attctgtttc ggagaatact       60

accggctcta atgcaattac cgcatctgct attaattcat ctttgcttac cgatggtaag      120

gtcgatgttt ctaaactgat gctggaaatt caaaaactcc tgggcaagat ggtgcgtata      180

ttgcaggatt accaacagca acagttgtcg cagagctatc agatccaact ggccgttttt      240

gagagccaga ataaagccat tgatgaaaaa aaggccgctg caacagccgc tctggttggt      300

ggggctattt catcagtatt ggggatctta ggctcttttg cagcaattaa cagtgctacg      360

aaaggcgcga gtgatattgc tcaaaaaacc gcctctacat cttctaaggc tattgatgcg      420

gcttctgata ctgcgactaa aacgttgact aaggcaacgg aaagcgttgc tgatgctgtt      480

gaagatgcat ccagcgtgat gcagcaagcg atgactacag caacgagagc ggccagccgt      540

acatccgacg ttgctgatga cattgccgat tctgctcaga gagcttctca gctggctgaa      600

aacgctgcag atgccgctca gaaggcaagt cgggcaagcc gctttatggc tgcagtagat      660

aagattactg gctctacacc atttattgcc gttaccagtc ttgccgaagg cacgaagaca      720

ttgccaacaa cggtatctga atcagtcaaa tctaaccatg agattagcga acagcgttat      780

aagtctgtgg agaacttcca gcagggtaat ttggatctgt ataagcaaga agttcgcaga      840

gcgcaggatg atatcgctag ccgtctgcgt gatatgacaa cagccgctcg cgatctcact      900

gatcttcaga atcgtatggg tcaatcggtt cgcttagctg ggtaa                      945


<210>  42
<211>  380
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  EspD, EPEC

Accession number: WP_000935767.1

<400>  42

Met Leu Asn Val Asn Ser Asp Ile Gln Ser Met Arg Ser Gly Ala Ser 
1               5                   10                  15      


Ala Ala Thr Ala Thr Ser Gly Ile Asn Gln Pro Glu Val Thr Ser Ala 
            20                  25                  30          


Leu Asp Leu Gln Leu Val Lys Ser Thr Ala Pro Ser Ala Ser Trp Thr 
        35                  40                  45              


Glu Ser Thr Ala Leu Pro Thr Pro Pro Ala Gly His Ser Leu Val Thr 
    50                  55                  60                  


Pro Ser Ala Ala Glu Asp Val Leu Ser Lys Leu Phe Gly Gly Ile Ser 
65                  70                  75                  80  


Gly Glu Val Arg Ser Arg Thr Glu Gly Thr Glu Pro Gln Arg Ser Thr 
                85                  90                  95      


Gln Asn Ala Ser Ser Gly Tyr Pro Tyr Leu Ser Gln Val Asn Asn Val 
            100                 105                 110         


Asp Pro Gln Ala Met Met Met Met Val Thr Leu Leu Ser Leu Asp Ala 
        115                 120                 125             


Ser Ala Gln Lys Val Ala Ser Met Lys Asn Ser Asn Glu Ile Tyr Thr 
    130                 135                 140                 


Asp Gly Gln Asn Lys Ala Leu Asp Asn Lys Thr Leu Glu Phe Lys Lys 
145                 150                 155                 160 


Gln Leu Glu Glu Gln Gln Lys Ala Glu Glu Lys Ala Gln Lys Ser Lys 
                165                 170                 175     


Ile Val Gly Gln Val Phe Gly Trp Leu Gly Val Ala Val Thr Ala Ile 
            180                 185                 190         


Ala Ala Ile Phe Asn Pro Ala Leu Trp Ala Val Val Ala Val Ser Ala 
        195                 200                 205             


Thr Ala Met Ala Leu Gln Thr Ala Val Asp Val Met Gly Asp Lys Ala 
    210                 215                 220                 


Pro Gln Ala Leu Lys Thr Ala Ala Gln Val Phe Gly Gly Val Ser Ile 
225                 230                 235                 240 


Ala Ala Ser Ile Leu Thr Ala Gly Ile Gly Gly Val Ser Ser Leu Met 
                245                 250                 255     


Ser Lys Val Gly Asp Val Ala Asn Lys Val Gly Ser Asn Ile Val Lys 
            260                 265                 270         


Thr Val Thr Lys Leu Ala Asp Val Phe Val Glu Asn Val Val Ser Lys 
        275                 280                 285             


Val Ala Ala Thr Ala Asn Gly Phe Thr Thr Ser Ala Arg Ser Ile Gly 
    290                 295                 300                 


Thr Thr Val Leu Asn Asn Asp Ser Ala Gln Tyr Ser Ile Leu Ala Gln 
305                 310                 315                 320 


Leu Ser Ala Tyr Ala Val Gln Asn Leu Thr Arg Gln Ser Glu Asn Leu 
                325                 330                 335     


Gly Glu Ser Ala Lys Val Glu Leu Asp Lys Ala Ala Ala Glu Leu Arg 
            340                 345                 350         


Asn Gln Ala Ser Tyr Leu Gln Asn Ala Ser Gln Leu Ile Ser Asp Ser 
        355                 360                 365             


Ala Arg Val Asn Ser Arg Ile Val Ser Gly Arg Val 
    370                 375                 380 


<210>  43
<211>  1000
<212>  DNA
<213>  Escherichia coli


<220>
<221>  misc_feature
<223>  EspD, EPEC

Accession number: CAI43861.1

<400>  43
atgctcaatg taaatagcga tatccagtcg atgaggtctg gggccagcgc tgctacggct       60

acttcaggta ttaatcagcc tgaagtgact tccgcgctgg atttacaact ggttaaatcc      120

acggccccat cagcaagttg gacagaaagt accgctttac caacgccacc ggcaggccac      180

tcattagtga cgccctctgc tgctgaggat gtcctgagta aactgtttgg tggtattagt      240

ggtgaagtta ggagtcgaac agagggaacc gaaccacagc gcagcactca gaatgcaagc      300

tctggctatc cttatctttc tcaggtgaat aacgttgacc ctcaggccat gatgatgatg      360

gtcaccctgt tatccctgga tgcttcagcg cagaaagttg cgagtatgaa aaactccaac      420

gagatctaca cggatgggca aaataaggcg ctggataata aaacgctgga gtttaaaaag      480

cagctcgaag aacaacagaa agccgaagag aaagcacaaa aaagtaaaat tgttggtcag      540

gtctttggtt ggttgggcgt cgcggtaact gctattgcag ctatttttaa cccggcactc      600

tgggctgttg ttgccgttag cgcaacagca atggcactgc aaactgcagt tgatgtaatg      660

ggcgataagg ccccgcaggc gttaaagaca gcagcgcaag tctttggcgg agtatctatt      720

gctgcaagta ttctgacagc cggcattggc ggggtgtctt cacttatgtc taaagttggc      780

gatgtcgcta acaaagttgg ttcaaacatc gtgaaaacag ttactaaact ggccgatgta      840

tttgttgaga acgttgtttc aaaagttgcg gcaacggcaa atggatttac gacctctgca      900

cgttctattg ggacaactgt gctgaataat gattctgcgc aatacagcat attggctcag      960

ttatctgctt acgcggtgca aaacttaact cgacagagtg                           1000


<210>  44
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PEPTIDE 49-50 SC

<400>  44

Cys Ala Glu Ala Thr Gln Glu Ala Asp Val Ala Glu Gln Ala Ser Lys 
1               5                   10                  15      


Ala Ser Gln Ala Cys 
            20      


<210>  45
<211>  312
<212>  PRT
<213>  Escherichia coli


<220>
<221>  MISC_FEATURE
<223>  EHEC-EspB

<400>  45

Met Asn Thr Ile Asp Asn Thr Gln Val Thr Met Val Asn Ser Ala Ser 
1               5                   10                  15      


Glu Ser Thr Thr Gly Ala Ser Ser Ala Val Ala Ala Ser Ala Leu Ser 
            20                  25                  30          


Ile Asp Ser Ser Leu Leu Thr Asp Gly Lys Val Asp Ile Cys Lys Leu 
        35                  40                  45              


Met Leu Glu Ile Gln Lys Leu Leu Gly Lys Met Val Thr Leu Leu Gln 
    50                  55                  60                  


Asp Tyr Gln Gln Lys Gln Leu Ala Gln Ser Tyr Gln Ile Gln Gln Ala 
65                  70                  75                  80  


Val Phe Glu Ser Gln Asn Lys Ala Ile Glu Glu Lys Lys Ala Ala Ala 
                85                  90                  95      


Thr Ala Ala Leu Val Gly Gly Ile Ile Ser Ser Ala Leu Gly Ile Leu 
            100                 105                 110         


Gly Ser Phe Ala Ala Met Asn Asn Ala Ala Lys Gly Ala Gly Glu Ile 
        115                 120                 125             


Ala Glu Lys Ala Ser Ser Ala Ser Ser Lys Ala Ala Gly Ala Ala Ser 
    130                 135                 140                 


Glu Val Ala Asn Lys Ala Leu Val Lys Ala Thr Glu Ser Val Ala Asp 
145                 150                 155                 160 


Val Ala Glu Glu Ala Ser Ser Ala Met Gln Lys Ala Met Ala Thr Thr 
                165                 170                 175     


Thr Lys Ala Ala Ser Arg Ala Ser Gly Val Ala Asp Asp Val Ala Lys 
            180                 185                 190         


Ala Ser Asp Phe Ala Glu Asp Leu Ala Asp Ala Ala Glu Lys Thr Ser 
        195                 200                 205             


Arg Ile Asn Lys Leu Leu Asn Ser Val Asp Lys Leu Thr Asn Thr Thr 
    210                 215                 220                 


Ala Phe Val Ala Val Thr Ser Leu Ala Glu Gly Thr Lys Thr Leu Pro 
225                 230                 235                 240 


Thr Thr Ile Ser Glu Ser Val Lys Ser Thr His Glu Val Asn Glu Gln 
                245                 250                 255     


Arg Ala Lys Ser Leu Glu Asn Phe Gln Gln Gly Asn Leu Glu Leu Tyr 
            260                 265                 270         


Lys Gln Asp Val Arg Arg Thr Gln Asp Asp Ile Thr Thr Arg Leu Arg 
        275                 280                 285             


Asp Ile Thr Ser Ala Val Arg Asp Leu Leu Glu Val Gln Asn Arg Met 
    290                 295                 300                 


Gly Gln Ser Gly Arg Leu Ala Gly 
305                 310         


<210>  46
<211>  321
<212>  PRT
<213>  Citrobacter rodentium


<220>
<221>  MISC_FEATURE
<223>  C. rodentium (CR)-EspB

<400>  46

Met Asn Thr Ile Asp Tyr Asn Asn Ala Ala Ile Ala Val Asn Pro Val 
1               5                   10                  15      


Val Ser Ser Thr Thr Asp Ser Ala Ser Ser Thr Thr Thr Leu Thr Ser 
            20                  25                  30          


Ser Ser Ser Ser Ser Leu Leu Thr Ala Gly Lys Val Asp Ile Ser Lys 
        35                  40                  45              


Leu Leu Leu Glu Val Gln Lys Leu Met Arg Glu Met Val Thr Thr Leu 
    50                  55                  60                  


Gln Asp Tyr Leu Gln Arg Gln Leu Ala Gln Ser Tyr Asn Ile Gln Gln 
65                  70                  75                  80  


Ala Ile Phe Gln Ser Gln Asn Lys Ala Ile Glu Glu Lys Lys Ala Gly 
                85                  90                  95      


Ala Thr Ala Ala Leu Ile Gly Gly Ala Ile Ser Ser Val Leu Gly Ile 
            100                 105                 110         


Leu Gly Ser Phe Ala Ala Ile Asn Ser Ala Thr Lys Gly Ala Ser Asp 
        115                 120                 125             


Val Val Gln Lys Ala Thr Ser Ala Ser Ala Lys Ser Val Asn Thr Ala 
    130                 135                 140                 


Ser Glu Val Ser Thr Lys Ala Leu Val Lys Ala Ser Glu Ser Ile Ala 
145                 150                 155                 160 


Asp Ala Ala Asp Glu Thr Val Gly Thr Leu Gln Gln Gly Ile Ala Ala 
                165                 170                 175     


Ala Thr Lys Ala Ala Asn Arg Thr Ser Gly Ile Ala Asp Asp Val Thr 
            180                 185                 190         


Thr Ser Ala Gln Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp Ala 
        195                 200                 205             


Ala Gln Asp Leu Thr Arg Lys Ala Asn Leu Leu Ser Arg Phe Thr Ala 
    210                 215                 220                 


Ala Ala Gly Arg Ile Ser Gly Ser Thr Ala Phe Val Val Val Thr Ser 
225                 230                 235                 240 


Leu Ala Glu Gly Thr Lys Thr Leu Pro Thr Thr Ile Ser Glu Ser Val 
                245                 250                 255     


Lys Ser Asn His Asp Ile Asn Glu Gln Arg Ala Lys Ser Val Glu Asn 
            260                 265                 270         


Leu Gln Ala Ser Asn Leu Glu Thr Tyr Lys Gln Asp Val Arg Arg Ser 
        275                 280                 285             


Gln Asp Asp Ile Ala Ser Arg Leu Arg Asp Met Thr Ala Thr Ala Arg 
    290                 295                 300                 


Asp Leu Asn Asp Leu Ile Asn Arg Met Gly Gln Ser Ala Arg Leu Ala 
305                 310                 315                 320 


Gly 
    


<210>  47
<211>  409
<212>  PRT
<213>  Salmonella


<220>
<221>  MISC_FEATURE
<223>  Salmonella-EspB A

<400>  47

Met Leu Ile Ser Asn Val Gly Ile Asn Pro Ala Ala Tyr Leu Asn Asn 
1               5                   10                  15      


His Ser Val Glu Asn Ser Ser Gln Thr Ala Ser Gln Ser Val Ser Ala 
            20                  25                  30          


Lys Asp Ile Leu Asn Ser Ile Gly Ile Ser Ser Ser Lys Val Ser Asp 
        35                  40                  45              


Leu Gly Leu Ser Pro Thr Leu Ser Ala Pro Ala Pro Gly Val Leu Thr 
    50                  55                  60                  


Gln Thr Pro Gly Thr Ile Thr Ser Phe Leu Lys Ala Ser Ile Gln Asn 
65                  70                  75                  80  


Thr Asp Met Asn Gln Asp Leu Asn Ala Leu Ala Asn Asn Val Thr Thr 
                85                  90                  95      


Lys Ala Asn Glu Val Val Gln Thr Gln Leu Arg Glu Gln Gln Ala Glu 
            100                 105                 110         


Val Gly Lys Phe Phe Asp Ile Ser Gly Met Ser Ser Ser Ala Val Ala 
        115                 120                 125             


Leu Leu Ala Ala Ala Asn Thr Leu Met Leu Thr Leu Asn Gln Ala Asp 
    130                 135                 140                 


Ser Lys Leu Ser Gly Lys Leu Ser Leu Val Ser Phe Asp Ala Ala Lys 
145                 150                 155                 160 


Thr Thr Ala Ser Ser Met Met Arg Glu Gly Met Asn Ala Leu Ser Gly 
                165                 170                 175     


Ser Ile Ser Gln Ser Ala Leu Gln Leu Gly Ile Thr Gly Val Gly Ala 
            180                 185                 190         


Lys Leu Glu Tyr Lys Gly Leu Gln Asn Glu Arg Gly Ala Leu Lys His 
        195                 200                 205             


Asn Ala Ala Lys Ile Asp Lys Leu Thr Thr Glu Ser His Ser Ile Lys 
    210                 215                 220                 


Asn Val Leu Asn Gly Gln Asn Ser Val Lys Leu Gly Ala Glu Gly Val 
225                 230                 235                 240 


Asp Ser Leu Lys Ser Leu Asn Met Lys Lys Thr Gly Thr Asp Ala Thr 
                245                 250                 255     


Lys Asn Leu Asn Asp Ala Thr Leu Lys Ser Asn Ala Gly Thr Ser Ala 
            260                 265                 270         


Thr Glu Ser Leu Gly Ile Lys Asp Ser Asn Lys Gln Ile Ser Pro Glu 
        275                 280                 285             


His Gln Ala Ile Leu Ser Lys Arg Leu Glu Ser Val Glu Ser Asp Ile 
    290                 295                 300                 


Arg Leu Glu Gln Asn Thr Met Asp Met Thr Arg Ile Asp Ala Arg Lys 
305                 310                 315                 320 


Met Gln Met Thr Gly Asp Leu Ile Met Lys Asn Ser Val Thr Val Gly 
                325                 330                 335     


Gly Ile Ala Gly Ala Ser Gly Gln Tyr Ala Ala Thr Gln Glu Arg Ser 
            340                 345                 350         


Glu Gln Gln Ile Ser Gln Val Asn Asn Arg Val Ala Ser Thr Ala Ser 
        355                 360                 365             


Asp Glu Ala Arg Glu Ser Ser Arg Lys Ser Thr Ser Leu Ile Gln Glu 
    370                 375                 380                 


Met Leu Lys Thr Met Glu Ser Ile Asn Gln Ser Lys Ala Ser Ala Leu 
385                 390                 395                 400 


Ala Ala Ile Ala Gly Asn Ile Arg Ala 
                405                 


<210>  48
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide #9-12

<400>  48

Ser Ile Ser Ser Ser Leu Leu Thr Asp Gly Arg Val Asp Ile Ser Lys 
1               5                   10                  15      


Leu Leu Leu Glu Val Gln Lys Leu Leu Arg Glu 
            20                  25          


<210>  49
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Epitope peptide

<400>  49

Lys Ala Ser Gln Val Ala Glu Glu Ala Ala Asp 
1               5                   10      


