﻿               SEQUENCE LISTING

<110> PAR’IMMUNE SAS
      CAPRON, Monique
      LACHGAR, Abderrahim

<120> 28 KDA GST PROTEINS FROM SCHISTOSOMA FOR THE TREATMENT OF VASCULITIS

<130> IBIO-1456/PCT

<150> EP20169888.3
<151> 2020-04-16

<160> 51

<170> BiSSAP 1.3.6

<210> 1
<211> 211
<212> PRT
<213> Schistosoma haematobium


<220> 
<223> Sh28GST

<400> 1
Met Thr Gly Asp His Ile Lys Val Ile Tyr Phe Asn Gly Arg Gly Arg 
1               5                   10                  15      
Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asn Tyr Glu 
            20                  25                  30          
Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro Thr Ile 
        35                  40                  45              
Pro Gly Gly Arg Leu Pro Ala Val Lys Ile Thr Asp Asn His Gly His 
    50                  55                  60                  
Val Lys Trp Met Val Glu Ser Leu Ala Ile Ala Arg Tyr Met Ala Lys 
65                  70                  75                  80  
Lys His His Met Met Gly Gly Thr Glu Glu Glu Tyr Tyr Asn Val Glu 
                85                  90                  95      
Lys Leu Ile Gly Gln Ala Glu Asp Leu Glu His Glu Tyr Tyr Lys Thr 
            100                 105                 110         
Leu Met Lys Pro Glu Glu Glu Lys Gln Lys Ile Ile Lys Glu Ile Leu 
        115                 120                 125             
Asn Gly Lys Val Pro Val Leu Leu Asp Ile Ile Cys Glu Ser Leu Lys 
    130                 135                 140                 
Ala Ser Thr Gly Lys Leu Ala Val Gly Asp Lys Val Thr Leu Ala Asp 
145                 150                 155                 160 
Leu Val Leu Ile Ala Val Ile Asp His Val Thr Asp Leu Asp Lys Glu 
                165                 170                 175     
Phe Leu Thr Gly Lys Tyr Pro Glu Ile His Lys His Arg Glu Asn Leu 
            180                 185                 190         
Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asp Arg Ala Ala 
        195                 200                 205             
Thr Pro Phe 
    210     

<210> 2
<211> 211
<212> PRT
<213> Schistosoma mansoni


<220> 
<223> Sm28GST

<400> 2
Met Ala Gly Glu His Ile Lys Val Ile Tyr Phe Asp Gly Arg Gly Arg 
1               5                   10                  15      
Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asp Tyr Glu 
            20                  25                  30          
Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro Thr Ile 
        35                  40                  45              
Pro Gly Gly Arg Leu Pro Ala Val Lys Val Thr Asp Asp His Gly His 
    50                  55                  60                  
Val Lys Trp Met Leu Glu Ser Leu Ala Ile Ala Arg Tyr Met Ala Lys 
65                  70                  75                  80  
Lys His His Met Met Gly Glu Thr Asp Glu Glu Tyr Tyr Ser Val Glu 
                85                  90                  95      
Lys Leu Ile Gly Gln Ala Glu Asp Val Glu His Glu Tyr His Lys Thr 
            100                 105                 110         
Leu Met Lys Pro Gln Glu Glu Lys Glu Lys Ile Thr Lys Glu Ile Leu 
        115                 120                 125             
Asn Gly Lys Val Pro Val Leu Leu Asn Met Ile Cys Glu Ser Leu Lys 
    130                 135                 140                 
Gly Ser Thr Gly Lys Leu Ala Val Gly Asp Lys Val Thr Leu Ala Asp 
145                 150                 155                 160 
Leu Val Leu Ile Ala Val Ile Asp His Val Thr Asp Leu Asp Lys Gly 
                165                 170                 175     
Phe Leu Thr Gly Lys Tyr Pro Glu Ile His Lys His Arg Glu Asn Leu 
            180                 185                 190         
Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asn Arg Pro Ala 
        195                 200                 205             
Thr Pro Phe 
    210     

<210> 3
<211> 211
<212> PRT
<213> Schistosoma bovis


<220> 
<223> Sb28GST

<400> 3
Met Thr Gly Asp His Ile Lys Val Ile Tyr Phe Asn Gly Arg Gly Arg 
1               5                   10                  15      
Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asn Tyr Glu 
            20                  25                  30          
Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro Thr Ile 
        35                  40                  45              
Pro Gly Gly Arg Leu Pro Ala Val Lys Ile Thr Asp Asn His Gly His 
    50                  55                  60                  
Val Lys Trp Met Leu Glu Ser Leu Ala Ile Ala Arg Tyr Met Ala Lys 
65                  70                  75                  80  
Lys His His Met Met Gly Glu Thr Asp Glu Glu Tyr Tyr Asn Val Glu 
                85                  90                  95      
Lys Leu Ile Gly Gln Val Glu Asp Leu Glu His Glu Tyr His Lys Thr 
            100                 105                 110         
Leu Met Lys Pro Glu Glu Glu Lys Gln Lys Ile Thr Lys Glu Ile Leu 
        115                 120                 125             
Asn Gly Lys Val Pro Val Leu Leu Asp Ile Ile Cys Glu Ser Leu Lys 
    130                 135                 140                 
Ala Ser Thr Gly Lys Leu Ala Val Gly Asp Lys Val Thr Leu Ala Asp 
145                 150                 155                 160 
Leu Val Leu Ile Ala Val Ile Asp His Val Thr Asp Leu Asp Lys Glu 
                165                 170                 175     
Phe Leu Thr Gly Lys Tyr Pro Glu Ile His Lys His Arg Glu Asn Leu 
            180                 185                 190         
Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asp Arg Ala Ala 
        195                 200                 205             
Thr Pro Phe 
    210     

<210> 4
<211> 792
<212> DNA
<213> Schistosoma haematobium


<220> 
<223> Sh28GST

<400> 4
tctgtctgac tgtatgatga ctggtgatca tatcaaggtt atctatttta acggacgcgg      60

acgagctgaa tcgatccgga tgacacttgt ggcagctggt gtgaactacg aagatgagag     120

aattagtttc caagattggc cgaaaatcaa accaactatt ccgggcggac gattgcctgc     180

agtgaaaatc accgataatc atgggcacgt gaaatggatg gtagagagtt tggctattgc     240

acggtatatg gcgaagaagc atcatatgat gggaggaaca gaagaggagt attataatgt     300

tgagaagttg attggtcagg ctgaagatct agaacatgaa tattacaaaa ctttgatgaa     360

gccagaagaa gagaaacaga agataatcaa agagatactg aacggcaaag taccagttct     420

tctcgatatt atctgcgaat ctctgaaagc gtccacaggc aagctggctg ttggggataa     480

agtgactcta gccgacttag ttctgattgc tgtcattgac catgtgactg atctggataa     540

agaatttcta actggcaagt atcctgagat ccataaacat agagaaaatc tactagccag     600

ttcaccgaga ttggcgaaat atttatcaga cagggctgca actcccttct agaactgtca     660

acagaatgct gggtgtgacg agattgaaga tactgatagt agtgcactgg tgcgaccttt     720

ttactaagac gtcatttgtt ttatggtatt ttttttcgca atcgttatta aaataaactt     780

agttttctgt tt                                                         792


<210> 5
<211> 211
<212> PRT
<213> Schistosoma japonicum


<220> 
<223> Sj28GST

<400> 5
Met Ala Cys Gly His Val Lys Leu Ile Tyr Phe Asn Gly Arg Gly Arg 
1               5                   10                  15      
Ala Glu Pro Ile Arg Met Ile Leu Val Ala Ala Gly Val Glu Phe Glu 
            20                  25                  30          
Asp Glu Arg Ile Glu Phe Gln Asp Trp Pro Lys Ile Lys Pro Thr Ile 
        35                  40                  45              
Pro Gly Gly Arg Leu Pro Ile Val Lys Ile Thr Asp Lys Arg Gly Asp 
    50                  55                  60                  
Val Lys Thr Met Ser Glu Ser Leu Ala Ile Ala Arg Phe Ile Ala Arg 
65                  70                  75                  80  
Lys His Asn Met Met Gly Asp Thr Asp Asp Glu Tyr Tyr Ile Ile Glu 
                85                  90                  95      
Lys Met Ile Gly Gln Val Glu Asp Val Glu Ser Glu Tyr His Lys Thr 
            100                 105                 110         
Leu Met Lys Pro Pro Glu Glu Lys Glu Lys Ile Ser Lys Glu Ile Leu 
        115                 120                 125             
Asn Gly Lys Val Pro Ile Leu Leu Gln Ala Ile Cys Glu Thr Leu Lys 
    130                 135                 140                 
Glu Ser Thr Gly Asn Leu Thr Val Gly Asp Lys Val Thr Leu Ala Asp 
145                 150                 155                 160 
Val Val Leu Ile Ala Ser Ile Asp His Ile Thr Asp Leu Asp Lys Glu 
                165                 170                 175     
Phe Leu Thr Gly Lys Tyr Pro Glu Ile His Lys His Arg Lys His Leu 
            180                 185                 190         
Leu Ala Thr Ser Pro Lys Leu Ala Lys Tyr Leu Ser Glu Arg His Ala 
        195                 200                 205             
Thr Ala Phe 
    210     

<210> 6
<211> 218
<212> PRT
<213> Schistosoma mansoni


<220> 
<223> Sm26GST isoform 1

<400> 6
Met Ala Pro Lys Phe Gly Tyr Trp Lys Val Lys Gly Leu Val Gln Pro 
1               5                   10                  15      
Thr Arg Leu Leu Leu Glu His Leu Glu Glu Thr Tyr Glu Glu Arg Ala 
            20                  25                  30          
Tyr Asp Arg Asn Glu Ile Asp Ala Trp Ser Asn Asp Lys Phe Lys Leu 
        35                  40                  45              
Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Phe Lys 
    50                  55                  60                  
Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  
Met Leu Gly Ala Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      
Gly Ala Val Leu Asp Ile Arg Met Gly Val Leu Arg Ile Ala Tyr Asn 
            100                 105                 110         
Lys Glu Tyr Glu Thr Leu Lys Val Asp Phe Leu Asn Lys Leu Pro Gly 
        115                 120                 125             
Arg Leu Lys Met Phe Glu Asp Arg Leu Ser Asn Lys Thr Tyr Leu Asn 
    130                 135                 140                 
Gly Asn Cys Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 
Val Val Leu Tyr Met Asp Ser Gln Cys Leu Asn Glu Phe Pro Lys Leu 
                165                 170                 175     
Val Ser Phe Lys Lys Cys Ile Glu Asp Leu Pro Gln Ile Lys Asn Tyr 
            180                 185                 190         
Leu Asn Ser Ser Arg Tyr Ile Lys Trp Pro Leu Gln Gly Trp Asp Ala 
        195                 200                 205             
Thr Phe Gly Gly Gly Asp Thr Pro Pro Lys 
    210                 215             

<210> 7
<211> 195
<212> PRT
<213> Schistosoma mansoni


<220> 
<223> Sm26GST isoform 2

<400> 7
Met Ala Pro Lys Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      
Thr Arg Leu Leu Leu Glu Tyr Leu Gly Glu Ala Tyr Glu Glu Arg Leu 
            20                  25                  30          
Tyr Asp Arg Asn Asp Gly Asp Val Trp Arg Asn Glu Lys Phe Lys Leu 
        35                  40                  45              
Gly Leu Asp Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  
Leu Thr Gln Ser Met Ala Ile Leu Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  
Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      
Gly Ala Ile Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Asn 
            100                 105                 110         
Lys Glu Phe Glu Thr Leu Lys Val Asp Phe Leu Asn Gln Leu Pro Gly 
        115                 120                 125             
Met Leu Lys Met Phe Glu Asp Arg Leu Ser His Asn Thr Tyr Leu Asn 
    130                 135                 140                 
Gly Asp Lys Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 
Val Asn Leu Pro Pro Ile Lys Asn Tyr Leu Asn Ser Asn Arg Tyr Ile 
                165                 170                 175     
Lys Trp Pro Leu Gln Gly Trp Ser Ala Thr Phe Gly Gly Gly Asp Ala 
            180                 185                 190         
Pro Pro Lys 
        195 

<210> 8
<211> 218
<212> PRT
<213> Schistosoma japonicum


<220> 
<223> Sj26GST

<400> 8
Met Ser Pro Ile Leu Gly Tyr Trp Lys Ile Lys Gly Leu Val Gln Pro 
1               5                   10                  15      
Thr Arg Leu Leu Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu 
            20                  25                  30          
Tyr Glu Arg Asp Glu Gly Asp Lys Trp Arg Asn Lys Lys Phe Glu Leu 
        35                  40                  45              
Gly Leu Glu Phe Pro Asn Leu Pro Tyr Tyr Ile Asp Gly Asp Val Lys 
    50                  55                  60                  
Leu Thr Gln Ser Met Ala Ile Ile Arg Tyr Ile Ala Asp Lys His Asn 
65                  70                  75                  80  
Met Leu Gly Gly Cys Pro Lys Glu Arg Ala Glu Ile Ser Met Leu Glu 
                85                  90                  95      
Gly Ala Val Leu Asp Ile Arg Tyr Gly Val Ser Arg Ile Ala Tyr Ser 
            100                 105                 110         
Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys Leu Pro Glu 
        115                 120                 125             
Met Leu Lys Met Phe Glu Asp Arg Leu Cys His Lys Thr Tyr Leu Asn 
    130                 135                 140                 
Gly Asp His Val Thr His Pro Asp Phe Met Leu Tyr Asp Ala Leu Asp 
145                 150                 155                 160 
Val Val Leu Tyr Met Asp Pro Met Cys Leu Asp Ala Phe Pro Lys Leu 
                165                 170                 175     
Val Cys Phe Lys Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr 
            180                 185                 190         
Leu Lys Ser Ser Lys Tyr Ile Ala Trp Pro Leu Gln Gly Trp Gln Ala 
        195                 200                 205             
Thr Phe Gly Gly Gly Asp His Pro Pro Lys 
    210                 215             

<210> 9
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> IL-1b forward primer

<400> 9
agctctccac ctcaatggac                                                20


<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> IL-1b reverse primer

<400> 10
aggccacagg tattttgtcg                                                20


<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> TNFa forward primer

<400> 11
cctgtagccc acgtcgtag                                                 19


<210> 12
<211> 22
<212> DNA
<213> Artificial Sequence


<220> 
<223> TNFa reverse primer

<400> 12
gggagtagac aaggtacaac cc                                             22


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> b-actin forward primer

<400> 13
ccttcttggg tatggaatcc t                                              21


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> b-actin reverse primer

<400> 14
ctttacggat gtcaacgtca c                                              21


<210> 15
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> iNOS forward primer

<400> 15
cagctgggct gtacaaacct t                                              21


<210> 16
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> iNOS reverse primer

<400> 16
cattggaagt gaagcgtttc a                                              21


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Arg1 forward primer

<400> 17
cagaagaatg gaagagtcag                                                20


<210> 18
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> Arg1 reverse primer

<400> 18
cagatatgca gggagtcacc                                                20


<210> 19
<211> 20
<212> PRT
<213> Schistosoma haematobium


<400> 19
Leu Val Ala Ala Gly Val Asn Tyr Glu Asp Glu Arg Ile Ser Phe Gln 
1               5                   10                  15      
Asp Trp Pro Lys 
            20  

<210> 20
<211> 20
<212> PRT
<213> Schistosoma mansoni


<400> 20
Leu Val Ala Ala Gly Val Asp Tyr Glu Asp Glu Arg Ile Ser Phe Gln 
1               5                   10                  15      
Asp Trp Pro Lys 
            20  

<210> 21
<211> 20
<212> PRT
<213> Schistosoma bovis


<400> 21
Leu Val Ala Ala Gly Val Asn Tyr Glu Asp Glu Arg Ile Ser Phe Gln 
1               5                   10                  15      
Asp Trp Pro Lys 
            20  

<210> 22
<211> 20
<212> PRT
<213> Schistosoma japonicum


<400> 22
Leu Val Ala Ala Gly Val Glu Phe Glu Asp Glu Arg Ile Glu Phe Gln 
1               5                   10                  15      
Asp Trp Pro Lys 
            20  

<210> 23
<211> 17
<212> PRT
<213> Schistosoma haematobium


<400> 23
Lys Pro Glu Glu Glu Lys Gln Lys Ile Ile Lys Glu Ile Leu Asn Gly 
1               5                   10                  15      
Lys 
    

<210> 24
<211> 17
<212> PRT
<213> Schistosoma mansoni


<400> 24
Lys Pro Gln Glu Glu Lys Glu Lys Ile Thr Lys Glu Ile Leu Asn Gly 
1               5                   10                  15      
Lys 
    

<210> 25
<211> 17
<212> PRT
<213> Schistosoma bovis


<400> 25
Lys Pro Glu Glu Glu Lys Gln Lys Ile Thr Lys Glu Ile Leu Asn Gly 
1               5                   10                  15      
Lys 
    

<210> 26
<211> 17
<212> PRT
<213> Schistosoma japonicum


<400> 26
Lys Pro Pro Glu Glu Lys Glu Lys Ile Ser Lys Glu Ile Leu Asn Gly 
1               5                   10                  15      
Lys 
    

<210> 27
<211> 22
<212> PRT
<213> Schistosoma haematobium


<400> 27
Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asp 
1               5                   10                  15      
Arg Ala Ala Thr Pro Phe 
            20          

<210> 28
<211> 22
<212> PRT
<213> Schistosoma mansoni


<400> 28
Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asn 
1               5                   10                  15      
Arg Pro Ala Thr Pro Phe 
            20          

<210> 29
<211> 22
<212> PRT
<213> Schistosoma bovis


<400> 29
Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys Tyr Leu Ser Asp 
1               5                   10                  15      
Arg Ala Ala Thr Pro Phe 
            20          

<210> 30
<211> 22
<212> PRT
<213> Schistosoma japonicum


<400> 30
Lys His Leu Leu Ala Thr Ser Pro Lys Leu Ala Lys Tyr Leu Ser Glu 
1               5                   10                  15      
Arg His Ala Thr Ala Phe 
            20          

<210> 31
<211> 46
<212> PRT
<213> Schistosoma haematobium


<400> 31
Gly Arg Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asn 
1               5                   10                  15      
Tyr Glu Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro 
            20                  25                  30          
Thr Ile Pro Gly Gly Arg Leu Pro Ala Val Lys Ile Thr Asp 
        35                  40                  45      

<210> 32
<211> 46
<212> PRT
<213> Schistosoma mansoni


<400> 32
Gly Arg Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asp 
1               5                   10                  15      
Tyr Glu Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro 
            20                  25                  30          
Thr Ile Pro Gly Gly Arg Leu Pro Ala Val Lys Val Thr Asp 
        35                  40                  45      

<210> 33
<211> 46
<212> PRT
<213> Schistosoma bovis


<400> 33
Gly Arg Ala Glu Ser Ile Arg Met Thr Leu Val Ala Ala Gly Val Asn 
1               5                   10                  15      
Tyr Glu Asp Glu Arg Ile Ser Phe Gln Asp Trp Pro Lys Ile Lys Pro 
            20                  25                  30          
Thr Ile Pro Gly Gly Arg Leu Pro Ala Val Lys Ile Thr Asp 
        35                  40                  45      

<210> 34
<211> 46
<212> PRT
<213> Schistosoma japonicum


<400> 34
Gly Arg Ala Glu Pro Ile Arg Met Ile Leu Val Ala Ala Gly Val Glu 
1               5                   10                  15      
Phe Glu Asp Glu Arg Ile Glu Phe Gln Asp Trp Pro Lys Ile Lys Pro 
            20                  25                  30          
Thr Ile Pro Gly Gly Arg Leu Pro Ile Val Lys Ile Thr Asp 
        35                  40                  45      

<210> 35
<211> 51
<212> PRT
<213> Schistosoma haematobium


<400> 35
Gly Gln Ala Glu Asp Leu Glu His Glu Tyr Tyr Lys Thr Leu Met Lys 
1               5                   10                  15      
Pro Glu Glu Glu Lys Gln Lys Ile Ile Lys Glu Ile Leu Asn Gly Lys 
            20                  25                  30          
Val Pro Val Leu Leu Asp Ile Ile Cys Glu Ser Leu Lys Ala Ser Thr 
        35                  40                  45              
Gly Lys Leu 
    50      

<210> 36
<211> 51
<212> PRT
<213> Schistosoma mansoni


<400> 36
Gly Gln Ala Glu Asp Val Glu His Glu Tyr His Lys Thr Leu Met Lys 
1               5                   10                  15      
Pro Gln Glu Glu Lys Glu Lys Ile Thr Lys Glu Ile Leu Asn Gly Lys 
            20                  25                  30          
Val Pro Val Leu Leu Asn Met Ile Cys Glu Ser Leu Lys Gly Ser Thr 
        35                  40                  45              
Gly Lys Leu 
    50      

<210> 37
<211> 51
<212> PRT
<213> Schistosoma bovis


<400> 37
Gly Gln Val Glu Asp Leu Glu His Glu Tyr His Lys Thr Leu Met Lys 
1               5                   10                  15      
Pro Glu Glu Glu Lys Gln Lys Ile Thr Lys Glu Ile Leu Asn Gly Lys 
            20                  25                  30          
Val Pro Val Leu Leu Asp Ile Ile Cys Glu Ser Leu Lys Ala Ser Thr 
        35                  40                  45              
Gly Lys Leu 
    50      

<210> 38
<211> 51
<212> PRT
<213> Schistosoma japonicum


<400> 38
Gly Gln Val Glu Asp Val Glu Ser Glu Tyr His Lys Thr Leu Met Lys 
1               5                   10                  15      
Pro Pro Glu Glu Lys Glu Lys Ile Ser Lys Glu Ile Leu Asn Gly Lys 
            20                  25                  30          
Val Pro Ile Leu Leu Gln Ala Ile Cys Glu Thr Leu Lys Glu Ser Thr 
        35                  40                  45              
Gly Asn Leu 
    50      

<210> 39
<211> 42
<212> PRT
<213> Schistosoma haematobium


<400> 39
Val Thr Asp Leu Asp Lys Glu Phe Leu Thr Gly Lys Tyr Pro Glu Ile 
1               5                   10                  15      
His Lys His Arg Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys 
            20                  25                  30          
Tyr Leu Ser Asp Arg Ala Ala Thr Pro Phe 
        35                  40          

<210> 40
<211> 42
<212> PRT
<213> Schistosoma mansoni


<400> 40
Val Thr Asp Leu Asp Lys Gly Phe Leu Thr Gly Lys Tyr Pro Glu Ile 
1               5                   10                  15      
His Lys His Arg Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys 
            20                  25                  30          
Tyr Leu Ser Asn Arg Pro Ala Thr Pro Phe 
        35                  40          

<210> 41
<211> 42
<212> PRT
<213> Schistosoma bovis


<400> 41
Val Thr Asp Leu Asp Lys Glu Phe Leu Thr Gly Lys Tyr Pro Glu Ile 
1               5                   10                  15      
His Lys His Arg Glu Asn Leu Leu Ala Ser Ser Pro Arg Leu Ala Lys 
            20                  25                  30          
Tyr Leu Ser Asp Arg Ala Ala Thr Pro Phe 
        35                  40          

<210> 42
<211> 42
<212> PRT
<213> Schistosoma japonicum


<400> 42
Ile Thr Asp Leu Asp Lys Glu Phe Leu Thr Gly Lys Tyr Pro Glu Ile 
1               5                   10                  15      
His Lys His Arg Lys His Leu Leu Ala Thr Ser Pro Lys Leu Ala Lys 
            20                  25                  30          
Tyr Leu Ser Glu Arg His Ala Thr Ala Phe 
        35                  40          

<210> 43
<211> 23
<212> PRT
<213> Schistosoma mansoni


<400> 43
Leu Glu His Leu Glu Glu Thr Tyr Glu Glu Arg Ala Tyr Asp Arg Asn 
1               5                   10                  15      
Glu Ile Asp Ala Trp Ser Asn 
            20              

<210> 44
<211> 23
<212> PRT
<213> Schistosoma mansoni


<400> 44
Leu Glu Tyr Leu Gly Glu Ala Tyr Glu Glu Arg Leu Tyr Asp Arg Asn 
1               5                   10                  15      
Asp Gly Asp Val Trp Arg Asn 
            20              

<210> 45
<211> 23
<212> PRT
<213> Schistosoma japonicum


<400> 45
Leu Glu Tyr Leu Glu Glu Lys Tyr Glu Glu His Leu Tyr Glu Arg Asp 
1               5                   10                  15      
Glu Gly Asp Lys Trp Arg Asn 
            20              

<210> 46
<211> 14
<212> PRT
<213> Schistosoma mansoni


<400> 46
Asn Lys Glu Tyr Glu Thr Leu Lys Val Asp Phe Leu Asn Lys 
1               5                   10                  

<210> 47
<211> 14
<212> PRT
<213> Schistosoma mansoni


<400> 47
Asn Lys Glu Phe Glu Thr Leu Lys Val Asp Phe Leu Asn Gln 
1               5                   10                  

<210> 48
<211> 14
<212> PRT
<213> Schistosoma japonicum


<400> 48
Ser Lys Asp Phe Glu Thr Leu Lys Val Asp Phe Leu Ser Lys 
1               5                   10                  

<210> 49
<211> 37
<212> PRT
<213> Schistosoma mansoni


<400> 49
Lys Cys Ile Glu Asp Leu Pro Gln Ile Lys Asn Tyr Leu Asn Ser Ser 
1               5                   10                  15      
Arg Tyr Ile Lys Trp Pro Leu Gln Gly Trp Asp Ala Thr Phe Gly Gly 
            20                  25                  30          
Gly Asp Thr Pro Pro 
        35          

<210> 50
<211> 16
<212> PRT
<213> Schistosoma mansoni


<400> 50
Ser Asn Arg Tyr Ile Lys Trp Pro Leu Gln Gly Trp Ser Ala Thr Phe 
1               5                   10                  15      



<210> 51
<211> 23
<212> PRT
<213> Schistosoma japonicum


<400> 51
Lys Arg Ile Glu Ala Ile Pro Gln Ile Asp Lys Tyr Leu Lys Ser Ser 
1               5                   10                  15      
Lys Tyr Ile Ala Trp Pro Leu 
            20              

