               SEQUENCE LISTING

<110> Nordic Bioscience A/S
      Karsdal Morten
      Mortensen Joachim Høg
      Pehrsson Martin
      Leeming Diana Julie
      Fisker Mette Juul
      Manon-Jensen Tina

<120> BIOMARKER OF FIBROSIS

<130> P21111WO

<150> GB2017987.5
<151> 2020-11-16
<150> GB2005564.6
<151> 2020-04-16

<160> 23

<170> BiSSAP 1.3.6

<210> 1
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 1
Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly 
1               5                   10  

<210> 2
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT
<222> 11
<223> Wherein X represents any amino acid

<400> 2
Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly Xaa 
1               5                   10      

<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<220> 
<221> VARIANT
<222> 12
<223> wherein X represents one or more amino acids of the sequence of
      collagen type III or wherein X is absent

<400> 3
Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly Asp Xaa 
1               5                   10          

<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 4
Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly Asp 
1               5                   10      

<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 5
Lys Ala Gly Gly Phe Ala Pro Tyr Tyr 
1               5                   

<210> 6
<211> 16
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 6
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      



<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 7
Arg Met Ser Asn Leu Ala Ser 
1               5           

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 8
Met Gln His Leu Glu Phe Pro Leu Thr 
1               5                   

<210> 9
<211> 5
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 9
Asp His Gly Met His 
1               5   

<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 10
Val Ile Ser Thr Tyr Tyr Gly Asp Ala Thr Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      
Gly 
    

<210> 11
<211> 13
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 11
Ser Met Gly Gly Asn Tyr Val Gly Thr Gly Phe Ala Tyr 
1               5                   10              

<210> 12
<211> 79
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 12
Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr 
1               5                   10                  15      
Trp Phe Leu Gln Arg Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg 
            20                  25                  30          
Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        35                  40                  45              
Ser Gly Thr Ala Phe Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp 
    50                  55                  60                  
Val Gly Val Tyr Tyr Cys Met Gln His Leu Glu Phe Pro Leu Thr 
65                  70                  75                  

<210> 13
<211> 81
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 13
Asp His Gly Met His Trp Val Lys Gln Ser Gln Ala Lys Ser Leu Glu 
1               5                   10                  15      
Trp Ile Gly Val Ile Ser Thr Tyr Tyr Gly Asp Ala Thr Tyr Asn Gln 
            20                  25                  30          
Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr 
        35                  40                  45              
Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr 
    50                  55                  60                  
Tyr Cys Ala Arg Ser Met Gly Gly Asn Tyr Val Gly Thr Gly Phe Ala 
65                  70                  75                  80  
Tyr 
    

<210> 14
<211> 112
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 14
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         



<210> 15
<211> 122
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 15
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly His Thr Phe Thr Asp His 
            20                  25                  30          
Gly Met His Trp Val Lys Gln Ser Gln Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Ser Thr Tyr Tyr Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Met Gly Gly Asn Tyr Val Gly Thr Gly Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120         

<210> 16
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<221> CROSSLNK
<222> 1
<223> Peptide is homodimerised by a N-terminal disulphide bridge

<220> 
<223> Synthetic Peptide

<400> 16
Cys Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly 
1               5                   10      

<210> 17
<211> 12
<212> PRT
<213> Artificial Sequence


<220> 
<221> CROSSLNK
<222> 1
<223> Peptide is homodimerised by a N-terminal disulphide bridge

<220> 
<223> Synthetic Peptide

<400> 17
Cys Lys Ala Gly Gly Phe Ala Pro Tyr Tyr Gly Asp 
1               5                   10          

<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<221> CROSSLNK
<222> 1
<223> Peptide is homodimerised by a N-terminal disulphide bridge

<220> 
<223> Synthetic Peptide

<400> 18
Cys Lys Ala Gly Gly Phe Ala Pro Tyr Tyr 
1               5                   10  

<210> 19
<211> 452
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 19
Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Val 
1               5                   10                  15      
Ser Val Lys Ile Ser Cys Lys Gly Ser Gly His Thr Phe Thr Asp His 
            20                  25                  30          
Gly Met His Trp Val Lys Gln Ser Gln Ala Lys Ser Leu Glu Trp Ile 
        35                  40                  45              
Gly Val Ile Ser Thr Tyr Tyr Gly Asp Ala Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  
Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  
Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Ser Met Gly Gly Asn Tyr Val Gly Thr Gly Phe Ala Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro 
        115                 120                 125             
Ser Val Tyr Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser 
    130                 135                 140                 
Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 
Leu Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro 
                165                 170                 175     
Ala Val Leu Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val 
            180                 185                 190         
Thr Ser Ser Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His 
        195                 200                 205             
Pro Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro 
    210                 215                 220                 
Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu 
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu 
                245                 250                 255     
Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         
Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu 
        275                 280                 285             
Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr 
    290                 295                 300                 
Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser 
305                 310                 315                 320 
Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro 
                325                 330                 335     
Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln 
            340                 345                 350         
Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val 
        355                 360                 365             
Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val 
    370                 375                 380                 
Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu 
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg 
                405                 410                 415     
Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val 
            420                 425                 430         
Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg 
        435                 440                 445             
Thr Pro Gly Lys 
    450         

<210> 20
<211> 218
<212> PRT
<213> Artificial Sequence


<220> 
<223> Synthetic Peptide

<400> 20
Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro Val Thr Pro Gly 
1               5                   10                  15      
Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 
            20                  25                  30          
Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              
Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro 
    50                  55                  60                  
Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  
Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln His 
                85                  90                  95      
Leu Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105                 110         
Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             
Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 
Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 
Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     
Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         
Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             
Pro Ile Val Lys Ser Phe Asn Arg Asn Glu 
    210                 215             

<210> 21
<211> 48
<212> PRT
<213> Rattus


<400> 21
Gly Ala Ala Ile Ala Gly Val Gly Gly Glu Lys Ser Gly Gly Phe Ser 
1               5                   10                  15      
Pro Tyr Tyr Gly Asp Asp Pro Met Asp Phe Lys Ile Asn Thr Glu Glu 
            20                  25                  30          
Ile Met Ser Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu Ile 
        35                  40                  45              



<210> 22
<211> 49
<212> PRT
<213> Muridae


<400> 22
Gly Ala Ala Ala Ile Ala Gly Val Gly Gly Glu Lys Ser Gly Gly Phe 
1               5                   10                  15      
Ser Pro Tyr Tyr Gly Asp Asp Pro Met Asp Phe Lys Ile Asn Thr Glu 
            20                  25                  30          
Glu Ile Met Ser Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser Leu 
        35                  40                  45              
Ile 
    

<210> 23
<211> 50
<212> PRT
<213> Homo sapiens


<400> 23
Val Gly Ala Ala Ala Ile Ala Gly Ile Gly Gly Glu Lys Ala Gly Gly 
1               5                   10                  15      
Phe Ala Pro Tyr Tyr Gly Asp Glu Pro Met Asp Phe Lys Ile Asn Thr 
            20                  25                  30          
Asp Glu Ile Met Thr Ser Leu Lys Ser Val Asn Gly Gln Ile Glu Ser 
        35                  40                  45              
Leu Ile 
    50  

