                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique
       Centre Hospitalier Universitaire de Montpellier
       Universit de Montpellier
 
<120>  Prognosis method of acute myeloid leukaemia

<130>  BR 107049

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  335
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ala Val Leu Gly Phe Glu Gly Ser Ala Asn Lys Ile Gly Val 
1               5                   10                  15      


Gly Val Val Arg Asp Gly Lys Val Leu Ala Asn Pro Arg Arg Thr Tyr 
            20                  25                  30          


Val Thr Pro Pro Gly Thr Gly Phe Leu Pro Gly Asp Thr Ala Arg His 
        35                  40                  45              


His Arg Ala Val Ile Leu Asp Leu Leu Gln Glu Ala Leu Thr Glu Ser 
    50                  55                  60                  


Gly Leu Thr Ser Gln Asp Ile Asp Cys Ile Ala Tyr Thr Lys Gly Pro 
65                  70                  75                  80  


Gly Met Gly Ala Pro Leu Val Ser Val Ala Val Val Ala Arg Thr Val 
                85                  90                  95      


Ala Gln Leu Trp Asn Lys Pro Leu Val Gly Val Asn His Cys Ile Gly 
            100                 105                 110         


His Ile Glu Met Gly Arg Leu Ile Thr Gly Ala Thr Ser Pro Thr Val 
        115                 120                 125             


Leu Tyr Val Ser Gly Gly Asn Thr Gln Val Ile Ala Tyr Ser Glu His 
    130                 135                 140                 


Arg Tyr Arg Ile Phe Gly Glu Thr Ile Asp Ile Ala Val Gly Asn Cys 
145                 150                 155                 160 


Leu Asp Arg Phe Ala Arg Val Leu Lys Ile Ser Asn Asp Pro Ser Pro 
                165                 170                 175     


Gly Tyr Asn Ile Glu Gln Met Ala Lys Arg Gly Lys Lys Leu Val Glu 
            180                 185                 190         


Leu Pro Tyr Thr Val Lys Gly Met Asp Val Ser Phe Ser Gly Ile Leu 
        195                 200                 205             


Ser Phe Ile Glu Asp Val Ala His Arg Met Leu Ala Thr Gly Glu Cys 
    210                 215                 220                 


Thr Pro Glu Asp Leu Cys Phe Ser Leu Gln Glu Thr Val Phe Ala Met 
225                 230                 235                 240 


Leu Val Glu Ile Thr Glu Arg Ala Met Ala His Cys Gly Ser Gln Glu 
                245                 250                 255     


Ala Leu Ile Val Gly Gly Val Gly Cys Asn Val Arg Leu Gln Glu Met 
            260                 265                 270         


Met Ala Thr Met Cys Gln Glu Arg Gly Ala Arg Leu Phe Ala Thr Asp 
        275                 280                 285             


Glu Arg Phe Cys Ile Asp Asn Gly Ala Met Ile Ala Gln Ala Gly Trp 
    290                 295                 300                 


Glu Met Phe Arg Ala Gly His Arg Thr Pro Leu Ser Asp Ser Gly Val 
305                 310                 315                 320 


Thr Gln Arg Tyr Arg Thr Asp Glu Val Glu Val Thr Trp Arg Asp 
                325                 330                 335 


<210>  2
<211>  1751
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Phe Ser Gly Ala Ser Trp Ser Thr Met Ala Lys Pro Thr 
1               5                   10                  15      


Ser Lys Asp Ser Gly Leu Lys Glu Lys Phe Lys Ile Leu Leu Gly Leu 
            20                  25                  30          


Gly Thr Pro Arg Pro Asn Pro Arg Ser Ala Glu Gly Lys Gln Thr Glu 
        35                  40                  45              


Phe Ile Ile Thr Ala Glu Ile Leu Arg Glu Leu Ser Met Glu Cys Gly 
    50                  55                  60                  


Leu Asn Asn Arg Ile Arg Met Ile Gly Gln Ile Cys Glu Val Ala Lys 
65                  70                  75                  80  


Thr Lys Lys Phe Glu Glu His Ala Val Glu Ala Leu Trp Lys Ala Val 
                85                  90                  95      


Ala Asp Leu Leu Gln Pro Glu Arg Pro Leu Glu Ala Arg His Ala Val 
            100                 105                 110         


Leu Ala Leu Leu Lys Ala Ile Val Gln Gly Gln Gly Glu Arg Leu Gly 
        115                 120                 125             


Val Leu Arg Ala Leu Phe Phe Lys Val Ile Lys Asp Tyr Pro Ser Asn 
    130                 135                 140                 


Glu Asp Leu His Glu Arg Leu Glu Val Phe Lys Ala Leu Thr Asp Asn 
145                 150                 155                 160 


Gly Arg His Ile Thr Tyr Leu Glu Glu Glu Leu Ala Asp Phe Val Leu 
                165                 170                 175     


Gln Trp Met Asp Val Gly Leu Ser Ser Glu Phe Leu Leu Val Leu Val 
            180                 185                 190         


Asn Leu Val Lys Phe Asn Ser Cys Tyr Leu Asp Glu Tyr Ile Ala Arg 
        195                 200                 205             


Met Val Gln Met Ile Cys Leu Leu Cys Val Arg Thr Ala Ser Ser Val 
    210                 215                 220                 


Asp Ile Glu Val Ser Leu Gln Val Leu Asp Ala Val Val Cys Tyr Asn 
225                 230                 235                 240 


Cys Leu Pro Ala Glu Ser Leu Pro Leu Phe Ile Val Thr Leu Cys Arg 
                245                 250                 255     


Thr Ile Asn Val Lys Glu Leu Cys Glu Pro Cys Trp Lys Leu Met Arg 
            260                 265                 270         


Asn Leu Leu Gly Thr His Leu Gly His Ser Ala Ile Tyr Asn Met Cys 
        275                 280                 285             


His Leu Met Glu Asp Arg Ala Tyr Met Glu Asp Ala Pro Leu Leu Arg 
    290                 295                 300                 


Gly Ala Val Phe Phe Val Gly Met Ala Leu Trp Gly Ala His Arg Leu 
305                 310                 315                 320 


Tyr Ser Leu Arg Asn Ser Pro Thr Ser Val Leu Pro Ser Phe Tyr Gln 
                325                 330                 335     


Ala Met Ala Cys Pro Asn Glu Val Val Ser Tyr Glu Ile Val Leu Ser 
            340                 345                 350         


Ile Thr Arg Leu Ile Lys Lys Tyr Arg Lys Glu Leu Gln Val Val Ala 
        355                 360                 365             


Trp Asp Ile Leu Leu Asn Ile Ile Glu Arg Leu Leu Gln Gln Leu Gln 
    370                 375                 380                 


Thr Leu Asp Ser Pro Glu Leu Arg Thr Ile Val His Asp Leu Leu Thr 
385                 390                 395                 400 


Thr Val Glu Glu Leu Cys Asp Gln Asn Glu Phe His Gly Ser Gln Glu 
                405                 410                 415     


Arg Tyr Phe Glu Leu Val Glu Arg Cys Ala Asp Gln Arg Pro Glu Ser 
            420                 425                 430         


Ser Leu Leu Asn Leu Ile Ser Tyr Arg Ala Gln Ser Ile His Pro Ala 
        435                 440                 445             


Lys Asp Gly Trp Ile Gln Asn Leu Gln Ala Leu Met Glu Arg Phe Phe 
    450                 455                 460                 


Arg Ser Glu Ser Arg Gly Ala Val Arg Ile Lys Val Leu Asp Val Leu 
465                 470                 475                 480 


Ser Phe Val Leu Leu Ile Asn Arg Gln Phe Tyr Glu Glu Glu Leu Ile 
                485                 490                 495     


Asn Ser Val Val Ile Ser Gln Leu Ser His Ile Pro Glu Asp Lys Asp 
            500                 505                 510         


His Gln Val Arg Lys Leu Ala Thr Gln Leu Leu Val Asp Leu Ala Glu 
        515                 520                 525             


Gly Cys His Thr His His Phe Asn Ser Leu Leu Asp Ile Ile Glu Lys 
    530                 535                 540                 


Val Met Ala Arg Ser Leu Ser Pro Pro Pro Glu Leu Glu Glu Arg Asp 
545                 550                 555                 560 


Val Ala Ala Tyr Ser Ala Ser Leu Glu Asp Val Lys Thr Ala Val Leu 
                565                 570                 575     


Gly Leu Leu Val Ile Leu Gln Thr Lys Leu Tyr Thr Leu Pro Ala Ser 
            580                 585                 590         


His Ala Thr Arg Val Tyr Glu Met Leu Val Ser His Ile Gln Leu His 
        595                 600                 605             


Tyr Lys His Ser Tyr Thr Leu Pro Ile Ala Ser Ser Ile Arg Leu Gln 
    610                 615                 620                 


Ala Phe Asp Phe Leu Leu Leu Leu Arg Ala Asp Ser Leu His Arg Leu 
625                 630                 635                 640 


Gly Leu Pro Asn Lys Asp Gly Val Val Arg Phe Ser Pro Tyr Cys Val 
                645                 650                 655     


Cys Asp Tyr Met Glu Pro Glu Arg Gly Ser Glu Lys Lys Thr Ser Gly 
            660                 665                 670         


Pro Leu Ser Pro Pro Thr Gly Pro Pro Gly Pro Ala Pro Ala Gly Pro 
        675                 680                 685             


Ala Val Arg Leu Gly Ser Val Pro Tyr Ser Leu Leu Phe Arg Val Leu 
    690                 695                 700                 


Leu Gln Cys Leu Lys Gln Glu Ser Asp Trp Lys Val Leu Lys Leu Val 
705                 710                 715                 720 


Leu Gly Arg Leu Pro Glu Ser Leu Arg Tyr Lys Val Leu Ile Phe Thr 
                725                 730                 735     


Ser Pro Cys Ser Val Asp Gln Leu Cys Ser Ala Leu Cys Ser Met Leu 
            740                 745                 750         


Ser Gly Pro Lys Thr Leu Glu Arg Leu Arg Gly Ala Pro Glu Gly Phe 
        755                 760                 765             


Ser Arg Thr Asp Leu His Leu Ala Val Val Pro Val Leu Thr Ala Leu 
    770                 775                 780                 


Ile Ser Tyr His Asn Tyr Leu Asp Lys Thr Lys Gln Arg Glu Met Val 
785                 790                 795                 800 


Tyr Cys Leu Glu Gln Gly Leu Ile His Arg Cys Ala Ser Gln Cys Val 
                805                 810                 815     


Val Ala Leu Ser Ile Cys Ser Val Glu Met Pro Asp Ile Ile Ile Lys 
            820                 825                 830         


Ala Leu Pro Val Leu Val Val Lys Leu Thr His Ile Ser Ala Thr Ala 
        835                 840                 845             


Ser Met Ala Val Pro Leu Leu Glu Phe Leu Ser Thr Leu Ala Arg Leu 
    850                 855                 860                 


Pro His Leu Tyr Arg Asn Phe Ala Ala Glu Gln Tyr Ala Ser Val Phe 
865                 870                 875                 880 


Ala Ile Ser Leu Pro Tyr Thr Asn Pro Ser Lys Phe Asn Gln Tyr Ile 
                885                 890                 895     


Val Cys Leu Ala His His Val Ile Ala Met Trp Phe Ile Arg Cys Arg 
            900                 905                 910         


Leu Pro Phe Arg Lys Asp Phe Val Pro Phe Ile Thr Lys Gly Leu Arg 
        915                 920                 925             


Ser Asn Val Leu Leu Ser Phe Asp Asp Thr Pro Glu Lys Asp Ser Phe 
    930                 935                 940                 


Arg Ala Arg Ser Thr Ser Leu Asn Glu Arg Pro Lys Arg Ile Gln Thr 
945                 950                 955                 960 


Ser Leu Thr Ser Ala Ser Leu Gly Ser Ala Asp Glu Asn Ser Val Ala 
                965                 970                 975     


Gln Ala Asp Asp Ser Leu Lys Asn Leu His Leu Glu Leu Thr Glu Thr 
            980                 985                 990         


Cys Leu Asp Met Met Ala Arg Tyr  Val Phe Ser Asn Phe  Thr Ala Val 
        995                 1000                 1005             


Pro Lys  Arg Ser Pro Val Gly  Glu Phe Leu Leu Ala  Gly Gly Arg 
    1010                 1015                 1020             


Thr Lys  Thr Trp Leu Val Gly  Asn Lys Leu Val Thr  Val Thr Thr 
    1025                 1030                 1035             


Ser Val  Gly Thr Gly Thr Arg  Ser Leu Leu Gly Leu  Asp Ser Gly 
    1040                 1045                 1050             


Glu Leu  Gln Ser Gly Pro Glu  Ser Ser Ser Ser Pro  Gly Val His 
    1055                 1060                 1065             


Val Arg  Gln Thr Lys Glu Ala  Pro Ala Lys Leu Glu  Ser Gln Ala 
    1070                 1075                 1080             


Gly Gln  Gln Val Ser Arg Gly  Ala Arg Asp Arg Val  Arg Ser Met 
    1085                 1090                 1095             


Ser Gly  Gly His Gly Leu Arg  Val Gly Ala Leu Asp  Val Pro Ala 
    1100                 1105                 1110             


Ser Gln  Phe Leu Gly Ser Ala  Thr Ser Pro Gly Pro  Arg Thr Ala 
    1115                 1120                 1125             


Pro Ala  Ala Lys Pro Glu Lys  Ala Ser Ala Gly Thr  Arg Val Pro 
    1130                 1135                 1140             


Val Gln  Glu Lys Thr Asn Leu  Ala Ala Tyr Val Pro  Leu Leu Thr 
    1145                 1150                 1155             


Gln Gly  Trp Ala Glu Ile Leu  Val Arg Arg Pro Thr  Gly Asn Thr 
    1160                 1165                 1170             


Ser Trp  Leu Met Ser Leu Glu  Asn Pro Leu Ser Pro  Phe Ser Ser 
    1175                 1180                 1185             


Asp Ile  Asn Asn Met Pro Leu  Gln Glu Leu Ser Asn  Ala Leu Met 
    1190                 1195                 1200             


Ala Ala  Glu Arg Phe Lys Glu  His Arg Asp Thr Ala  Leu Tyr Lys 
    1205                 1210                 1215             


Ser Leu  Ser Val Pro Ala Ala  Ser Thr Ala Lys Pro  Pro Pro Leu 
    1220                 1225                 1230             


Pro Arg  Ser Asn Thr Asp Ser  Ala Val Val Met Glu  Glu Gly Ser 
    1235                 1240                 1245             


Pro Gly  Glu Val Pro Val Leu  Val Glu Pro Pro Gly  Leu Glu Asp 
    1250                 1255                 1260             


Val Glu  Ala Ala Leu Gly Met  Asp Arg Arg Thr Asp  Ala Tyr Ser 
    1265                 1270                 1275             


Arg Ser  Ser Ser Val Ser Ser  Gln Glu Glu Lys Ser  Leu His Ala 
    1280                 1285                 1290             


Glu Glu  Leu Val Gly Arg Gly  Ile Pro Ile Glu Arg  Val Val Ser 
    1295                 1300                 1305             


Ser Glu  Gly Gly Arg Pro Ser  Val Asp Leu Ser Phe  Gln Pro Ser 
    1310                 1315                 1320             


Gln Pro  Leu Ser Lys Ser Ser  Ser Ser Pro Glu Leu  Gln Thr Leu 
    1325                 1330                 1335             


Gln Asp  Ile Leu Gly Asp Pro  Gly Asp Lys Ala Asp  Val Gly Arg 
    1340                 1345                 1350             


Leu Ser  Pro Glu Val Lys Ala  Arg Ser Gln Ser Gly  Thr Leu Asp 
    1355                 1360                 1365             


Gly Glu  Ser Ala Ala Trp Ser  Ala Ser Gly Glu Asp  Ser Arg Gly 
    1370                 1375                 1380             


Gln Pro  Glu Gly Pro Leu Pro  Ser Ser Ser Pro Arg  Ser Pro Ser 
    1385                 1390                 1395             


Gly Leu  Arg Pro Arg Gly Tyr  Thr Ile Ser Asp Ser  Ala Pro Ser 
    1400                 1405                 1410             


Arg Arg  Gly Lys Arg Val Glu  Arg Asp Ala Leu Lys  Ser Arg Ala 
    1415                 1420                 1425             


Thr Ala  Ser Asn Ala Glu Lys  Val Pro Gly Ile Asn  Pro Ser Phe 
    1430                 1435                 1440             


Val Phe  Leu Gln Leu Tyr His  Ser Pro Phe Phe Gly  Asp Glu Ser 
    1445                 1450                 1455             


Asn Lys  Pro Ile Leu Leu Pro  Asn Glu Ser Gln Ser  Phe Glu Arg 
    1460                 1465                 1470             


Ser Val  Gln Leu Leu Asp Gln  Ile Pro Ser Tyr Asp  Thr His Lys 
    1475                 1480                 1485             


Ile Ala  Val Leu Tyr Val Gly  Glu Gly Gln Ser Asn  Ser Glu Leu 
    1490                 1495                 1500             


Ala Ile  Leu Ser Asn Glu His  Gly Ser Tyr Arg Tyr  Thr Glu Phe 
    1505                 1510                 1515             


Leu Thr  Gly Leu Gly Arg Leu  Ile Glu Leu Lys Asp  Cys Gln Pro 
    1520                 1525                 1530             


Asp Lys  Val Tyr Leu Gly Gly  Leu Asp Val Cys Gly  Glu Asp Gly 
    1535                 1540                 1545             


Gln Phe  Thr Tyr Cys Trp His  Asp Asp Ile Met Gln  Ala Val Phe 
    1550                 1555                 1560             


His Ile  Ala Thr Leu Met Pro  Thr Lys Asp Val Asp  Lys His Arg 
    1565                 1570                 1575             


Cys Asp  Lys Lys Arg His Leu  Gly Asn Asp Phe Val  Ser Ile Val 
    1580                 1585                 1590             


Tyr Asn  Asp Ser Gly Glu Asp  Phe Lys Leu Gly Thr  Ile Lys Gly 
    1595                 1600                 1605             


Gln Phe  Asn Phe Val His Val  Ile Val Thr Pro Leu  Asp Tyr Glu 
    1610                 1615                 1620             


Cys Asn  Leu Val Ser Leu Gln  Cys Arg Lys Asp Met  Glu Gly Leu 
    1625                 1630                 1635             


Val Asp  Thr Ser Val Ala Lys  Ile Val Ser Asp Arg  Asn Leu Pro 
    1640                 1645                 1650             


Phe Val  Ala Arg Gln Met Ala  Leu His Ala Asn Met  Ala Ser Gln 
    1655                 1660                 1665             


Val His  His Ser Arg Ser Asn  Pro Thr Asp Ile Tyr  Pro Ser Lys 
    1670                 1675                 1680             


Trp Ile  Ala Arg Leu Arg His  Ile Lys Arg Leu Arg  Gln Arg Ile 
    1685                 1690                 1695             


Cys Glu  Glu Ala Ala Tyr Ser  Asn Pro Ser Leu Pro  Leu Val His 
    1700                 1705                 1710             


Pro Pro  Ser His Ser Lys Ala  Pro Ala Gln Thr Pro  Ala Glu Pro 
    1715                 1720                 1725             


Thr Pro  Gly Tyr Glu Val Gly  Gln Arg Lys Arg Leu  Ile Ser Ser 
    1730                 1735                 1740             


Val Glu  Asp Phe Thr Glu Phe  Val 
    1745                 1750     


<210>  3
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ile Gly Gln Lys Thr Leu Tyr Ser Phe Phe Ser Pro Ser Pro Ala 
1               5                   10                  15      


Arg Lys Arg His Ala Pro Ser Pro Glu Pro Ala Val Gln Gly Thr Gly 
            20                  25                  30          


Val Ala Gly Val Pro Glu Glu Ser Gly Asp Ala Ala Ala Ile Pro Ala 
        35                  40                  45              


Lys Lys Ala Pro Ala Gly Gln Glu Glu Pro Gly Thr Pro Pro Ser Ser 
    50                  55                  60                  


Pro Leu Ser Ala Glu Gln Leu Asp Arg Ile Gln Arg Asn Lys Ala Ala 
65                  70                  75                  80  


Ala Leu Leu Arg Leu Ala Ala Arg Asn Val Pro Val Gly Phe Gly Glu 
                85                  90                  95      


Ser Trp Lys Lys His Leu Ser Gly Glu Phe Gly Lys Pro Tyr Phe Ile 
            100                 105                 110         


Lys Leu Met Gly Phe Val Ala Glu Glu Arg Lys His Tyr Thr Val Tyr 
        115                 120                 125             


Pro Pro Pro His Gln Val Phe Thr Trp Thr Gln Met Cys Asp Ile Lys 
    130                 135                 140                 


Asp Val Lys Val Val Ile Leu Gly Gln Asp Pro Tyr His Gly Pro Asn 
145                 150                 155                 160 


Gln Ala His Gly Leu Cys Phe Ser Val Gln Arg Pro Val Pro Pro Pro 
                165                 170                 175     


Pro Ser Leu Glu Asn Ile Tyr Lys Glu Leu Ser Thr Asp Ile Glu Asp 
            180                 185                 190         


Phe Val His Pro Gly His Gly Asp Leu Ser Gly Trp Ala Lys Gln Gly 
        195                 200                 205             


Val Leu Leu Leu Asn Ala Val Leu Thr Val Arg Ala His Gln Ala Asn 
    210                 215                 220                 


Ser His Lys Glu Arg Gly Trp Glu Gln Phe Thr Asp Ala Val Val Ser 
225                 230                 235                 240 


Trp Leu Asn Gln Asn Ser Asn Gly Leu Val Phe Leu Leu Trp Gly Ser 
                245                 250                 255     


Tyr Ala Gln Lys Lys Gly Ser Ala Ile Asp Arg Lys Arg His His Val 
            260                 265                 270         


Leu Gln Thr Ala His Pro Ser Pro Leu Ser Val Tyr Arg Gly Phe Phe 
        275                 280                 285             


Gly Cys Arg His Phe Ser Lys Thr Asn Glu Leu Leu Gln Lys Ser Gly 
    290                 295                 300                 


Lys Lys Pro Ile Asp Trp Lys Glu Leu 
305                 310             


<210>  4
<211>  633
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Glu Ile Arg Leu Arg His Val Val Ser Cys Ser Ser Gln Asp 
1               5                   10                  15      


Ser Thr His Cys Ala Glu Asn Leu Leu Lys Ala Asp Thr Tyr Arg Lys 
            20                  25                  30          


Trp Arg Ala Ala Lys Ala Gly Glu Lys Thr Ile Ser Val Val Leu Gln 
        35                  40                  45              


Leu Glu Lys Glu Glu Gln Ile His Ser Val Asp Ile Gly Asn Asp Gly 
    50                  55                  60                  


Ser Ala Phe Val Glu Val Leu Val Gly Ser Ser Ala Gly Gly Ala Gly 
65                  70                  75                  80  


Glu Gln Asp Tyr Glu Val Leu Leu Val Thr Ser Ser Phe Met Ser Pro 
                85                  90                  95      


Ser Glu Ser Arg Ser Gly Ser Asn Pro Asn Arg Val Arg Met Phe Gly 
            100                 105                 110         


Pro Asp Lys Leu Val Arg Ala Ala Ala Glu Lys Arg Trp Asp Arg Val 
        115                 120                 125             


Lys Ile Val Cys Ser Gln Pro Tyr Ser Lys Asp Ser Pro Phe Gly Leu 
    130                 135                 140                 


Ser Phe Val Arg Phe His Ser Pro Pro Asp Lys Asp Glu Ala Glu Ala 
145                 150                 155                 160 


Pro Ser Gln Lys Val Thr Val Thr Lys Leu Gly Gln Phe Arg Val Lys 
                165                 170                 175     


Glu Glu Asp Glu Ser Ala Asn Ser Leu Arg Pro Gly Ala Leu Phe Phe 
            180                 185                 190         


Ser Arg Ile Asn Lys Thr Ser Pro Val Thr Ala Ser Asp Pro Ala Gly 
        195                 200                 205             


Pro Ser Tyr Ala Ala Ala Thr Leu Gln Ala Ser Ser Ala Ala Ser Ser 
    210                 215                 220                 


Ala Ser Pro Val Ser Arg Ala Ile Gly Ser Thr Ser Lys Pro Gln Glu 
225                 230                 235                 240 


Ser Pro Lys Gly Lys Arg Lys Leu Asp Leu Asn Gln Glu Glu Lys Lys 
                245                 250                 255     


Thr Pro Ser Lys Pro Pro Ala Gln Leu Ser Pro Ser Val Pro Lys Arg 
            260                 265                 270         


Pro Lys Leu Pro Ala Pro Thr Arg Thr Pro Ala Thr Ala Pro Val Pro 
        275                 280                 285             


Ala Arg Ala Gln Gly Ala Val Thr Gly Lys Pro Arg Gly Glu Gly Thr 
    290                 295                 300                 


Glu Pro Arg Arg Pro Arg Ala Gly Pro Glu Glu Leu Gly Lys Ile Leu 
305                 310                 315                 320 


Gln Gly Val Val Val Val Leu Ser Gly Phe Gln Asn Pro Phe Arg Ser 
                325                 330                 335     


Glu Leu Arg Asp Lys Ala Leu Glu Leu Gly Ala Lys Tyr Arg Pro Asp 
            340                 345                 350         


Trp Thr Arg Asp Ser Thr His Leu Ile Cys Ala Phe Ala Asn Thr Pro 
        355                 360                 365             


Lys Tyr Ser Gln Val Leu Gly Leu Gly Gly Arg Ile Val Arg Lys Glu 
    370                 375                 380                 


Trp Val Leu Asp Cys His Arg Met Arg Arg Arg Leu Pro Ser Gln Arg 
385                 390                 395                 400 


Tyr Leu Met Ala Gly Pro Gly Ser Ser Ser Glu Glu Asp Glu Ala Ser 
                405                 410                 415     


His Ser Gly Gly Ser Gly Asp Glu Ala Pro Lys Leu Pro Gln Lys Gln 
            420                 425                 430         


Pro Gln Thr Lys Thr Lys Pro Thr Gln Ala Ala Gly Pro Ser Ser Pro 
        435                 440                 445             


Gln Lys Pro Pro Thr Pro Glu Glu Thr Lys Ala Ala Ser Pro Val Leu 
    450                 455                 460                 


Gln Glu Asp Ile Asp Ile Glu Gly Val Gln Ser Glu Gly Gln Asp Asn 
465                 470                 475                 480 


Gly Ala Glu Asp Ser Gly Asp Thr Glu Asp Glu Leu Arg Arg Val Ala 
                485                 490                 495     


Glu Gln Lys Glu His Arg Leu Pro Pro Gly Gln Glu Glu Asn Gly Glu 
            500                 505                 510         


Asp Pro Tyr Ala Gly Ser Thr Asp Glu Asn Thr Asp Ser Glu Glu His 
        515                 520                 525             


Gln Glu Pro Pro Asp Leu Pro Val Pro Glu Leu Pro Asp Phe Phe Gln 
    530                 535                 540                 


Gly Lys His Phe Phe Leu Tyr Gly Glu Phe Pro Gly Asp Glu Arg Arg 
545                 550                 555                 560 


Lys Leu Ile Arg Tyr Val Thr Ala Phe Asn Gly Glu Leu Glu Asp Tyr 
                565                 570                 575     


Met Ser Asp Arg Val Gln Phe Val Ile Thr Ala Gln Glu Trp Asp Pro 
            580                 585                 590         


Ser Phe Glu Glu Ala Leu Met Asp Asn Pro Ser Leu Ala Phe Val Arg 
        595                 600                 605             


Pro Arg Trp Ile Tyr Ser Cys Asn Glu Lys Gln Lys Leu Leu Pro His 
    610                 615                 620                 


Gln Leu Tyr Gly Val Val Pro Gln Ala 
625                 630             


<210>  5
<211>  2644
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Gly Glu His Gly Leu Glu Leu Ala Ser Met Ile Pro Ala Leu Arg 
1               5                   10                  15      


Glu Leu Gly Ser Ala Thr Pro Glu Glu Tyr Asn Thr Val Val Gln Lys 
            20                  25                  30          


Pro Arg Gln Ile Leu Cys Gln Phe Ile Asp Arg Ile Leu Thr Asp Val 
        35                  40                  45              


Asn Val Val Ala Val Glu Leu Val Lys Lys Thr Asp Ser Gln Pro Thr 
    50                  55                  60                  


Ser Val Met Leu Leu Asp Phe Ile Gln His Ile Met Lys Ser Ser Pro 
65                  70                  75                  80  


Leu Met Phe Val Asn Val Ser Gly Ser His Glu Ala Lys Gly Ser Cys 
                85                  90                  95      


Ile Glu Phe Ser Asn Trp Ile Ile Thr Arg Leu Leu Arg Ile Ala Ala 
            100                 105                 110         


Thr Pro Ser Cys His Leu Leu His Lys Lys Ile Cys Glu Val Ile Cys 
        115                 120                 125             


Ser Leu Leu Phe Leu Phe Lys Ser Lys Ser Pro Ala Ile Phe Gly Val 
    130                 135                 140                 


Leu Thr Lys Glu Leu Leu Gln Leu Phe Glu Asp Leu Val Tyr Leu His 
145                 150                 155                 160 


Arg Arg Asn Val Met Gly His Ala Val Glu Trp Pro Val Val Met Ser 
                165                 170                 175     


Arg Phe Leu Ser Gln Leu Asp Glu His Met Gly Tyr Leu Gln Ser Ala 
            180                 185                 190         


Pro Leu Gln Leu Met Ser Met Gln Asn Leu Glu Phe Ile Glu Val Thr 
        195                 200                 205             


Leu Leu Met Val Leu Thr Arg Ile Ile Ala Ile Val Phe Phe Arg Arg 
    210                 215                 220                 


Gln Glu Leu Leu Leu Trp Gln Ile Gly Cys Val Leu Leu Glu Tyr Gly 
225                 230                 235                 240 


Ser Pro Lys Ile Lys Ser Leu Ala Ile Ser Phe Leu Thr Glu Leu Phe 
                245                 250                 255     


Gln Leu Gly Gly Leu Pro Ala Gln Pro Ala Ser Thr Phe Phe Ser Ser 
            260                 265                 270         


Phe Leu Glu Leu Leu Lys His Leu Val Glu Met Asp Thr Asp Gln Leu 
        275                 280                 285             


Lys Leu Tyr Glu Glu Pro Leu Ser Lys Leu Ile Lys Thr Leu Phe Pro 
    290                 295                 300                 


Phe Glu Ala Glu Ala Tyr Arg Asn Ile Glu Pro Val Tyr Leu Asn Met 
305                 310                 315                 320 


Leu Leu Glu Lys Leu Cys Val Met Phe Glu Asp Gly Val Leu Met Arg 
                325                 330                 335     


Leu Lys Ser Asp Leu Leu Lys Ala Ala Leu Cys His Leu Leu Gln Tyr 
            340                 345                 350         


Phe Leu Lys Phe Val Pro Ala Gly Tyr Glu Ser Ala Leu Gln Val Arg 
        355                 360                 365             


Lys Val Tyr Val Arg Asn Ile Cys Lys Ala Leu Leu Asp Val Leu Gly 
    370                 375                 380                 


Ile Glu Val Asp Ala Glu Tyr Leu Leu Gly Pro Leu Tyr Ala Ala Leu 
385                 390                 395                 400 


Lys Met Glu Ser Met Glu Ile Ile Glu Glu Ile Gln Cys Gln Thr Gln 
                405                 410                 415     


Gln Glu Asn Leu Ser Ser Asn Ser Asp Gly Ile Ser Pro Lys Arg Arg 
            420                 425                 430         


Arg Leu Ser Ser Ser Leu Asn Pro Ser Lys Arg Ala Pro Lys Gln Thr 
        435                 440                 445             


Glu Glu Ile Lys His Val Asp Met Asn Gln Lys Ser Ile Leu Trp Ser 
    450                 455                 460                 


Ala Leu Lys Gln Lys Ala Glu Ser Leu Gln Ile Ser Leu Glu Tyr Ser 
465                 470                 475                 480 


Gly Leu Lys Asn Pro Val Ile Glu Met Leu Glu Gly Ile Ala Val Val 
                485                 490                 495     


Leu Gln Leu Thr Ala Leu Cys Thr Val His Cys Ser His Gln Asn Met 
            500                 505                 510         


Asn Cys Arg Thr Phe Lys Asp Cys Gln His Lys Ser Lys Lys Lys Pro 
        515                 520                 525             


Ser Val Val Ile Thr Trp Met Ser Leu Asp Phe Tyr Thr Lys Val Leu 
    530                 535                 540                 


Lys Ser Cys Arg Ser Leu Leu Glu Ser Val Gln Lys Leu Asp Leu Glu 
545                 550                 555                 560 


Ala Thr Ile Asp Lys Val Val Lys Ile Tyr Asp Ala Leu Ile Tyr Met 
                565                 570                 575     


Gln Val Asn Ser Ser Phe Glu Asp His Ile Leu Glu Asp Leu Cys Gly 
            580                 585                 590         


Met Leu Ser Leu Pro Trp Ile Tyr Ser His Ser Asp Asp Gly Cys Leu 
        595                 600                 605             


Lys Leu Thr Thr Phe Ala Ala Asn Leu Leu Thr Leu Ser Cys Arg Ile 
    610                 615                 620                 


Ser Asp Ser Tyr Ser Pro Gln Ala Gln Ser Arg Cys Val Phe Leu Leu 
625                 630                 635                 640 


Thr Leu Phe Pro Arg Arg Ile Phe Leu Glu Trp Arg Thr Ala Val Tyr 
                645                 650                 655     


Asn Trp Ala Leu Gln Ser Ser His Glu Val Ile Arg Ala Ser Cys Val 
            660                 665                 670         


Ser Gly Phe Phe Ile Leu Leu Gln Gln Gln Asn Ser Cys Asn Arg Val 
        675                 680                 685             


Pro Lys Ile Leu Ile Asp Lys Val Lys Asp Asp Ser Asp Ile Val Lys 
    690                 695                 700                 


Lys Glu Phe Ala Ser Ile Leu Gly Gln Leu Val Cys Thr Leu His Gly 
705                 710                 715                 720 


Met Phe Tyr Leu Thr Ser Ser Leu Thr Glu Pro Phe Ser Glu His Gly 
                725                 730                 735     


His Val Asp Leu Phe Cys Arg Asn Leu Lys Ala Thr Ser Gln His Glu 
            740                 745                 750         


Cys Ser Ser Ser Gln Leu Lys Ala Ser Val Cys Lys Pro Phe Leu Phe 
        755                 760                 765             


Leu Leu Lys Lys Lys Ile Pro Ser Pro Val Lys Leu Ala Phe Ile Asp 
    770                 775                 780                 


Asn Leu His His Leu Cys Lys His Leu Asp Phe Arg Glu Asp Glu Thr 
785                 790                 795                 800 


Asp Val Lys Ala Val Leu Gly Thr Leu Leu Asn Leu Met Glu Asp Pro 
                805                 810                 815     


Asp Lys Asp Val Arg Val Ala Phe Ser Gly Asn Ile Lys His Ile Leu 
            820                 825                 830         


Glu Ser Leu Asp Ser Glu Asp Gly Phe Ile Lys Glu Leu Phe Val Leu 
        835                 840                 845             


Arg Met Lys Glu Ala Tyr Thr His Ala Gln Ile Ser Arg Asn Asn Glu 
    850                 855                 860                 


Leu Lys Asp Thr Leu Ile Leu Thr Thr Gly Asp Ile Gly Arg Ala Ala 
865                 870                 875                 880 


Lys Gly Asp Leu Val Pro Phe Ala Leu Leu His Leu Leu His Cys Leu 
                885                 890                 895     


Leu Ser Lys Ser Ala Ser Val Ser Gly Ala Ala Tyr Thr Glu Ile Arg 
            900                 905                 910         


Ala Leu Val Ala Ala Lys Ser Val Lys Leu Gln Ser Phe Phe Ser Gln 
        915                 920                 925             


Tyr Lys Lys Pro Ile Cys Gln Phe Leu Val Glu Ser Leu His Ser Ser 
    930                 935                 940                 


Gln Met Thr Ala Leu Pro Asn Thr Pro Cys Gln Asn Ala Asp Val Arg 
945                 950                 955                 960 


Lys Gln Asp Val Ala His Gln Arg Glu Met Ala Leu Asn Thr Leu Ser 
                965                 970                 975     


Glu Ile Ala Asn Val Phe Asp Phe Pro Asp Leu Asn Arg Phe Leu Thr 
            980                 985                 990         


Arg Thr Leu Gln Val Leu Leu Pro  Asp Leu Ala Ala Lys  Ala Ser Pro 
        995                 1000                 1005             


Ala Ala  Ser Ala Leu Ile Arg  Thr Leu Gly Lys Gln  Leu Asn Val 
    1010                 1015                 1020             


Asn Arg  Arg Glu Ile Leu Ile  Asn Asn Phe Lys Tyr  Ile Phe Ser 
    1025                 1030                 1035             


His Leu  Val Cys Ser Cys Ser  Lys Asp Glu Leu Glu  Arg Ala Leu 
    1040                 1045                 1050             


His Tyr  Leu Lys Asn Glu Thr  Glu Ile Glu Leu Gly  Ser Leu Leu 
    1055                 1060                 1065             


Arg Gln  Asp Phe Gln Gly Leu  His Asn Glu Leu Leu  Leu Arg Ile 
    1070                 1075                 1080             


Gly Glu  His Tyr Gln Gln Val  Phe Asn Gly Leu Ser  Ile Leu Ala 
    1085                 1090                 1095             


Ser Phe  Ala Ser Ser Asp Asp  Pro Tyr Gln Gly Pro  Arg Asp Ile 
    1100                 1105                 1110             


Ile Ser  Pro Glu Leu Met Ala  Asp Tyr Leu Gln Pro  Lys Leu Leu 
    1115                 1120                 1125             


Gly Ile  Leu Ala Phe Phe Asn  Met Gln Leu Leu Ser  Ser Ser Val 
    1130                 1135                 1140             


Gly Ile  Glu Asp Lys Lys Met  Ala Leu Asn Ser Leu  Met Ser Leu 
    1145                 1150                 1155             


Met Lys  Leu Met Gly Pro Lys  His Val Ser Ser Val  Arg Val Lys 
    1160                 1165                 1170             


Met Met  Thr Thr Leu Arg Thr  Gly Leu Arg Phe Lys  Asp Asp Phe 
    1175                 1180                 1185             


Pro Glu  Leu Cys Cys Arg Ala  Trp Asp Cys Phe Val  Arg Cys Leu 
    1190                 1195                 1200             


Asp His  Ala Cys Leu Gly Ser  Leu Leu Ser His Val  Ile Val Ala 
    1205                 1210                 1215             


Leu Leu  Pro Leu Ile His Ile  Gln Pro Lys Glu Thr  Ala Ala Ile 
    1220                 1225                 1230             


Phe His  Tyr Leu Ile Ile Glu  Asn Arg Asp Ala Val  Gln Asp Phe 
    1235                 1240                 1245             


Leu His  Glu Ile Tyr Phe Leu  Pro Asp His Pro Glu  Leu Lys Lys 
    1250                 1255                 1260             


Ile Lys  Ala Val Leu Gln Glu  Tyr Arg Lys Glu Thr  Ser Glu Ser 
    1265                 1270                 1275             


Thr Asp  Leu Gln Thr Thr Leu  Gln Leu Ser Met Lys  Ala Ile Gln 
    1280                 1285                 1290             


His Glu  Asn Val Asp Val Arg  Ile His Ala Leu Thr  Ser Leu Lys 
    1295                 1300                 1305             


Glu Thr  Leu Tyr Lys Asn Gln  Glu Lys Leu Ile Lys  Tyr Ala Thr 
    1310                 1315                 1320             


Asp Ser  Glu Thr Val Glu Pro  Ile Ile Ser Gln Leu  Val Thr Val 
    1325                 1330                 1335             


Leu Leu  Lys Gly Cys Gln Asp  Ala Asn Ser Gln Ala  Arg Leu Leu 
    1340                 1345                 1350             


Cys Gly  Glu Cys Leu Gly Glu  Leu Gly Ala Ile Asp  Pro Gly Arg 
    1355                 1360                 1365             


Leu Asp  Phe Ser Thr Thr Glu  Thr Gln Gly Lys Asp  Phe Thr Phe 
    1370                 1375                 1380             


Val Thr  Gly Val Glu Asp Ser  Ser Phe Ala Tyr Gly  Leu Leu Met 
    1385                 1390                 1395             


Glu Leu  Thr Arg Ala Tyr Leu  Ala Tyr Ala Asp Asn  Ser Arg Ala 
    1400                 1405                 1410             


Gln Asp  Ser Ala Ala Tyr Ala  Ile Gln Glu Leu Leu  Ser Ile Tyr 
    1415                 1420                 1425             


Asp Cys  Arg Glu Met Glu Thr  Asn Gly Pro Gly His  Gln Leu Trp 
    1430                 1435                 1440             


Arg Arg  Phe Pro Glu His Val  Arg Glu Ile Leu Glu  Pro His Leu 
    1445                 1450                 1455             


Asn Thr  Arg Tyr Lys Ser Ser  Gln Lys Ser Thr Asp  Trp Ser Gly 
    1460                 1465                 1470             


Val Lys  Lys Pro Ile Tyr Leu  Ser Lys Leu Gly Ser  Asn Phe Ala 
    1475                 1480                 1485             


Glu Trp  Ser Ala Ser Trp Ala  Gly Tyr Leu Ile Thr  Lys Val Arg 
    1490                 1495                 1500             


His Asp  Leu Ala Ser Lys Ile  Phe Thr Cys Cys Ser  Ile Met Met 
    1505                 1510                 1515             


Lys His  Asp Phe Lys Val Thr  Ile Tyr Leu Leu Pro  His Ile Leu 
    1520                 1525                 1530             


Val Tyr  Val Leu Leu Gly Cys  Asn Gln Glu Asp Gln  Gln Glu Val 
    1535                 1540                 1545             


Tyr Ala  Glu Ile Met Ala Val  Leu Lys His Asp Asp  Gln His Thr 
    1550                 1555                 1560             


Ile Asn  Thr Gln Asp Ile Ala  Ser Asp Leu Cys Gln  Leu Ser Thr 
    1565                 1570                 1575             


Gln Thr  Val Phe Ser Met Leu  Asp His Leu Thr Gln  Trp Ala Arg 
    1580                 1585                 1590             


His Lys  Phe Gln Ala Leu Lys  Ala Glu Lys Cys Pro  His Ser Lys 
    1595                 1600                 1605             


Ser Asn  Arg Asn Lys Val Asp  Ser Met Val Ser Thr  Val Asp Tyr 
    1610                 1615                 1620             


Glu Asp  Tyr Gln Ser Val Thr  Arg Phe Leu Asp Leu  Ile Pro Gln 
    1625                 1630                 1635             


Asp Thr  Leu Ala Val Ala Ser  Phe Arg Ser Lys Ala  Tyr Thr Arg 
    1640                 1645                 1650             


Ala Val  Met His Phe Glu Ser  Phe Ile Thr Glu Lys  Lys Gln Asn 
    1655                 1660                 1665             


Ile Gln  Glu His Leu Gly Phe  Leu Gln Lys Leu Tyr  Ala Ala Met 
    1670                 1675                 1680             


His Glu  Pro Asp Gly Val Ala  Gly Val Ser Ala Ile  Arg Lys Ala 
    1685                 1690                 1695             


Glu Pro  Ser Leu Lys Glu Gln  Ile Leu Glu His Glu  Ser Leu Gly 
    1700                 1705                 1710             


Leu Leu  Arg Asp Ala Thr Ala  Cys Tyr Asp Arg Ala  Ile Gln Leu 
    1715                 1720                 1725             


Glu Pro  Asp Gln Ile Ile His  Tyr His Gly Val Val  Lys Ser Met 
    1730                 1735                 1740             


Leu Gly  Leu Gly Gln Leu Ser  Thr Val Ile Thr Gln  Val Asn Gly 
    1745                 1750                 1755             


Val His  Ala Asn Arg Ser Glu  Trp Thr Asp Glu Leu  Asn Thr Tyr 
    1760                 1765                 1770             


Arg Val  Glu Ala Ala Trp Lys  Leu Ser Gln Trp Asp  Leu Val Glu 
    1775                 1780                 1785             


Asn Tyr  Leu Ala Ala Asp Gly  Lys Ser Thr Thr Trp  Ser Val Arg 
    1790                 1795                 1800             


Leu Gly  Gln Leu Leu Leu Ser  Ala Lys Lys Arg Asp  Ile Thr Ala 
    1805                 1810                 1815             


Phe Tyr  Asp Ser Leu Lys Leu  Val Arg Ala Glu Gln  Ile Val Pro 
    1820                 1825                 1830             


Leu Ser  Ala Ala Ser Phe Glu  Arg Gly Ser Tyr Gln  Arg Gly Tyr 
    1835                 1840                 1845             


Glu Tyr  Ile Val Arg Leu His  Met Leu Cys Glu Leu  Glu His Ser 
    1850                 1855                 1860             


Ile Lys  Pro Leu Phe Gln His  Ser Pro Gly Asp Ser  Ser Gln Glu 
    1865                 1870                 1875             


Asp Ser  Leu Asn Trp Val Ala  Arg Leu Glu Met Thr  Gln Asn Ser 
    1880                 1885                 1890             


Tyr Arg  Ala Lys Glu Pro Ile  Leu Ala Leu Arg Arg  Ala Leu Leu 
    1895                 1900                 1905             


Ser Leu  Asn Lys Arg Pro Asp  Tyr Asn Glu Met Val  Gly Glu Cys 
    1910                 1915                 1920             


Trp Leu  Gln Ser Ala Arg Val  Ala Arg Lys Ala Gly  His His Gln 
    1925                 1930                 1935             


Thr Ala  Tyr Asn Ala Leu Leu  Asn Ala Gly Glu Ser  Arg Leu Ala 
    1940                 1945                 1950             


Glu Leu  Tyr Val Glu Arg Ala  Lys Trp Leu Trp Ser  Lys Gly Asp 
    1955                 1960                 1965             


Val His  Gln Ala Leu Ile Val  Leu Gln Lys Gly Val  Glu Leu Cys 
    1970                 1975                 1980             


Phe Pro  Glu Asn Glu Thr Pro  Pro Glu Gly Lys Asn  Met Leu Ile 
    1985                 1990                 1995             


His Gly  Arg Ala Met Leu Leu  Val Gly Arg Phe Met  Glu Glu Thr 
    2000                 2005                 2010             


Ala Asn  Phe Glu Ser Asn Ala  Ile Met Lys Lys Tyr  Lys Asp Val 
    2015                 2020                 2025             


Thr Ala  Cys Leu Pro Glu Trp  Glu Asp Gly His Phe  Tyr Leu Ala 
    2030                 2035                 2040             


Lys Tyr  Tyr Asp Lys Leu Met  Pro Met Val Thr Asp  Asn Lys Met 
    2045                 2050                 2055             


Glu Lys  Gln Gly Asp Leu Ile  Arg Tyr Ile Val Leu  His Phe Gly 
    2060                 2065                 2070             


Arg Ser  Leu Gln Tyr Gly Asn  Gln Phe Ile Tyr Gln  Ser Met Pro 
    2075                 2080                 2085             


Arg Met  Leu Thr Leu Trp Leu  Asp Tyr Gly Thr Lys  Ala Tyr Glu 
    2090                 2095                 2100             


Trp Glu  Lys Ala Gly Arg Ser  Asp Arg Val Gln Met  Arg Asn Asp 
    2105                 2110                 2115             


Leu Gly  Lys Ile Asn Lys Val  Ile Thr Glu His Thr  Asn Tyr Leu 
    2120                 2125                 2130             


Ala Pro  Tyr Gln Phe Leu Thr  Ala Phe Ser Gln Leu  Ile Ser Arg 
    2135                 2140                 2145             


Ile Cys  His Ser His Asp Glu  Val Phe Val Val Leu  Met Glu Ile 
    2150                 2155                 2160             


Ile Ala  Lys Val Phe Leu Ala  Tyr Pro Gln Gln Ala  Met Trp Met 
    2165                 2170                 2175             


Met Thr  Ala Val Ser Lys Ser  Ser Tyr Pro Met Arg  Val Asn Arg 
    2180                 2185                 2190             


Cys Lys  Glu Ile Leu Asn Lys  Ala Ile His Met Lys  Lys Ser Leu 
    2195                 2200                 2205             


Glu Lys  Phe Val Gly Asp Ala  Thr Arg Leu Thr Asp  Lys Leu Leu 
    2210                 2215                 2220             


Glu Leu  Cys Asn Lys Pro Val  Asp Gly Ser Ser Ser  Thr Leu Ser 
    2225                 2230                 2235             


Met Ser  Thr His Phe Lys Met  Leu Lys Lys Leu Val  Glu Glu Ala 
    2240                 2245                 2250             


Thr Phe  Ser Glu Ile Leu Ile  Pro Leu Gln Ser Val  Met Ile Pro 
    2255                 2260                 2265             


Thr Leu  Pro Ser Ile Leu Gly  Thr His Ala Asn His  Ala Ser His 
    2270                 2275                 2280             


Glu Pro  Phe Pro Gly His Trp  Ala Tyr Ile Ala Gly  Phe Asp Asp 
    2285                 2290                 2295             


Met Val  Glu Ile Leu Ala Ser  Leu Gln Lys Pro Lys  Lys Ile Ser 
    2300                 2305                 2310             


Leu Lys  Gly Ser Asp Gly Lys  Phe Tyr Ile Met Met  Cys Lys Pro 
    2315                 2320                 2325             


Lys Asp  Asp Leu Arg Lys Asp  Cys Arg Leu Met Glu  Phe Asn Ser 
    2330                 2335                 2340             


Leu Ile  Asn Lys Cys Leu Arg  Lys Asp Ala Glu Ser  Arg Arg Arg 
    2345                 2350                 2355             


Glu Leu  His Ile Arg Thr Tyr  Ala Val Ile Pro Leu  Asn Asp Glu 
    2360                 2365                 2370             


Cys Gly  Ile Ile Glu Trp Val  Asn Asn Thr Ala Gly  Leu Arg Pro 
    2375                 2380                 2385             


Ile Leu  Thr Lys Leu Tyr Lys  Glu Lys Gly Val Tyr  Met Thr Gly 
    2390                 2395                 2400             


Lys Glu  Leu Arg Gln Cys Met  Leu Pro Lys Ser Ala  Ala Leu Ser 
    2405                 2410                 2415             


Glu Lys  Leu Lys Val Phe Arg  Glu Phe Leu Leu Pro  Arg His Pro 
    2420                 2425                 2430             


Pro Ile  Phe His Glu Trp Phe  Leu Arg Thr Phe Pro  Asp Pro Thr 
    2435                 2440                 2445             


Ser Trp  Tyr Ser Ser Arg Ser  Ala Tyr Cys Arg Ser  Thr Ala Val 
    2450                 2455                 2460             


Met Ser  Met Val Gly Tyr Ile  Leu Gly Leu Gly Asp  Arg His Gly 
    2465                 2470                 2475             


Glu Asn  Ile Leu Phe Asp Ser  Leu Thr Gly Glu Cys  Val His Val 
    2480                 2485                 2490             


Asp Phe  Asn Cys Leu Phe Asn  Lys Gly Glu Thr Phe  Glu Val Pro 
    2495                 2500                 2505             


Glu Ile  Val Pro Phe Arg Leu  Thr His Asn Met Val  Asn Gly Met 
    2510                 2515                 2520             


Gly Pro  Met Gly Thr Glu Gly  Leu Phe Arg Arg Ala  Cys Glu Val 
    2525                 2530                 2535             


Thr Met  Arg Leu Met Arg Asp  Gln Arg Glu Pro Leu  Met Ser Val 
    2540                 2545                 2550             


Leu Lys  Thr Phe Leu His Asp  Pro Leu Val Glu Trp  Ser Lys Pro 
    2555                 2560                 2565             


Val Lys  Gly His Ser Lys Ala  Pro Leu Asn Glu Thr  Gly Glu Val 
    2570                 2575                 2580             


Val Asn  Glu Lys Ala Lys Thr  His Val Leu Asp Ile  Glu Gln Arg 
    2585                 2590                 2595             


Leu Gln  Gly Val Ile Lys Thr  Arg Asn Arg Val Thr  Gly Leu Pro 
    2600                 2605                 2610             


Leu Ser  Ile Glu Gly His Val  His Tyr Leu Ile Gln  Glu Ala Thr 
    2615                 2620                 2625             


Asp Glu  Asn Leu Leu Cys Gln  Met Tyr Leu Gly Trp  Thr Pro Tyr 
    2630                 2635                 2640             


Met 
    


<210>  6
<211>  3418
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ile Gly Ser Lys Glu Arg Pro Thr Phe Phe Glu Ile Phe Lys 
1               5                   10                  15      


Thr Arg Cys Asn Lys Ala Asp Leu Gly Pro Ile Ser Leu Asn Trp Phe 
            20                  25                  30          


Glu Glu Leu Ser Ser Glu Ala Pro Pro Tyr Asn Ser Glu Pro Ala Glu 
        35                  40                  45              


Glu Ser Glu His Lys Asn Asn Asn Tyr Glu Pro Asn Leu Phe Lys Thr 
    50                  55                  60                  


Pro Gln Arg Lys Pro Ser Tyr Asn Gln Leu Ala Ser Thr Pro Ile Ile 
65                  70                  75                  80  


Phe Lys Glu Gln Gly Leu Thr Leu Pro Leu Tyr Gln Ser Pro Val Lys 
                85                  90                  95      


Glu Leu Asp Lys Phe Lys Leu Asp Leu Gly Arg Asn Val Pro Asn Ser 
            100                 105                 110         


Arg His Lys Ser Leu Arg Thr Val Lys Thr Lys Met Asp Gln Ala Asp 
        115                 120                 125             


Asp Val Ser Cys Pro Leu Leu Asn Ser Cys Leu Ser Glu Ser Pro Val 
    130                 135                 140                 


Val Leu Gln Cys Thr His Val Thr Pro Gln Arg Asp Lys Ser Val Val 
145                 150                 155                 160 


Cys Gly Ser Leu Phe His Thr Pro Lys Phe Val Lys Gly Arg Gln Thr 
                165                 170                 175     


Pro Lys His Ile Ser Glu Ser Leu Gly Ala Glu Val Asp Pro Asp Met 
            180                 185                 190         


Ser Trp Ser Ser Ser Leu Ala Thr Pro Pro Thr Leu Ser Ser Thr Val 
        195                 200                 205             


Leu Ile Val Arg Asn Glu Glu Ala Ser Glu Thr Val Phe Pro His Asp 
    210                 215                 220                 


Thr Thr Ala Asn Val Lys Ser Tyr Phe Ser Asn His Asp Glu Ser Leu 
225                 230                 235                 240 


Lys Lys Asn Asp Arg Phe Ile Ala Ser Val Thr Asp Ser Glu Asn Thr 
                245                 250                 255     


Asn Gln Arg Glu Ala Ala Ser His Gly Phe Gly Lys Thr Ser Gly Asn 
            260                 265                 270         


Ser Phe Lys Val Asn Ser Cys Lys Asp His Ile Gly Lys Ser Met Pro 
        275                 280                 285             


Asn Val Leu Glu Asp Glu Val Tyr Glu Thr Val Val Asp Thr Ser Glu 
    290                 295                 300                 


Glu Asp Ser Phe Ser Leu Cys Phe Ser Lys Cys Arg Thr Lys Asn Leu 
305                 310                 315                 320 


Gln Lys Val Arg Thr Ser Lys Thr Arg Lys Lys Ile Phe His Glu Ala 
                325                 330                 335     


Asn Ala Asp Glu Cys Glu Lys Ser Lys Asn Gln Val Lys Glu Lys Tyr 
            340                 345                 350         


Ser Phe Val Ser Glu Val Glu Pro Asn Asp Thr Asp Pro Leu Asp Ser 
        355                 360                 365             


Asn Val Ala Asn Gln Lys Pro Phe Glu Ser Gly Ser Asp Lys Ile Ser 
    370                 375                 380                 


Lys Glu Val Val Pro Ser Leu Ala Cys Glu Trp Ser Gln Leu Thr Leu 
385                 390                 395                 400 


Ser Gly Leu Asn Gly Ala Gln Met Glu Lys Ile Pro Leu Leu His Ile 
                405                 410                 415     


Ser Ser Cys Asp Gln Asn Ile Ser Glu Lys Asp Leu Leu Asp Thr Glu 
            420                 425                 430         


Asn Lys Arg Lys Lys Asp Phe Leu Thr Ser Glu Asn Ser Leu Pro Arg 
        435                 440                 445             


Ile Ser Ser Leu Pro Lys Ser Glu Lys Pro Leu Asn Glu Glu Thr Val 
    450                 455                 460                 


Val Asn Lys Arg Asp Glu Glu Gln His Leu Glu Ser His Thr Asp Cys 
465                 470                 475                 480 


Ile Leu Ala Val Lys Gln Ala Ile Ser Gly Thr Ser Pro Val Ala Ser 
                485                 490                 495     


Ser Phe Gln Gly Ile Lys Lys Ser Ile Phe Arg Ile Arg Glu Ser Pro 
            500                 505                 510         


Lys Glu Thr Phe Asn Ala Ser Phe Ser Gly His Met Thr Asp Pro Asn 
        515                 520                 525             


Phe Lys Lys Glu Thr Glu Ala Ser Glu Ser Gly Leu Glu Ile His Thr 
    530                 535                 540                 


Val Cys Ser Gln Lys Glu Asp Ser Leu Cys Pro Asn Leu Ile Asp Asn 
545                 550                 555                 560 


Gly Ser Trp Pro Ala Thr Thr Thr Gln Asn Ser Val Ala Leu Lys Asn 
                565                 570                 575     


Ala Gly Leu Ile Ser Thr Leu Lys Lys Lys Thr Asn Lys Phe Ile Tyr 
            580                 585                 590         


Ala Ile His Asp Glu Thr Ser Tyr Lys Gly Lys Lys Ile Pro Lys Asp 
        595                 600                 605             


Gln Lys Ser Glu Leu Ile Asn Cys Ser Ala Gln Phe Glu Ala Asn Ala 
    610                 615                 620                 


Phe Glu Ala Pro Leu Thr Phe Ala Asn Ala Asp Ser Gly Leu Leu His 
625                 630                 635                 640 


Ser Ser Val Lys Arg Ser Cys Ser Gln Asn Asp Ser Glu Glu Pro Thr 
                645                 650                 655     


Leu Ser Leu Thr Ser Ser Phe Gly Thr Ile Leu Arg Lys Cys Ser Arg 
            660                 665                 670         


Asn Glu Thr Cys Ser Asn Asn Thr Val Ile Ser Gln Asp Leu Asp Tyr 
        675                 680                 685             


Lys Glu Ala Lys Cys Asn Lys Glu Lys Leu Gln Leu Phe Ile Thr Pro 
    690                 695                 700                 


Glu Ala Asp Ser Leu Ser Cys Leu Gln Glu Gly Gln Cys Glu Asn Asp 
705                 710                 715                 720 


Pro Lys Ser Lys Lys Val Ser Asp Ile Lys Glu Glu Val Leu Ala Ala 
                725                 730                 735     


Ala Cys His Pro Val Gln His Ser Lys Val Glu Tyr Ser Asp Thr Asp 
            740                 745                 750         


Phe Gln Ser Gln Lys Ser Leu Leu Tyr Asp His Glu Asn Ala Ser Thr 
        755                 760                 765             


Leu Ile Leu Thr Pro Thr Ser Lys Asp Val Leu Ser Asn Leu Val Met 
    770                 775                 780                 


Ile Ser Arg Gly Lys Glu Ser Tyr Lys Met Ser Asp Lys Leu Lys Gly 
785                 790                 795                 800 


Asn Asn Tyr Glu Ser Asp Val Glu Leu Thr Lys Asn Ile Pro Met Glu 
                805                 810                 815     


Lys Asn Gln Asp Val Cys Ala Leu Asn Glu Asn Tyr Lys Asn Val Glu 
            820                 825                 830         


Leu Leu Pro Pro Glu Lys Tyr Met Arg Val Ala Ser Pro Ser Arg Lys 
        835                 840                 845             


Val Gln Phe Asn Gln Asn Thr Asn Leu Arg Val Ile Gln Lys Asn Gln 
    850                 855                 860                 


Glu Glu Thr Thr Ser Ile Ser Lys Ile Thr Val Asn Pro Asp Ser Glu 
865                 870                 875                 880 


Glu Leu Phe Ser Asp Asn Glu Asn Asn Phe Val Phe Gln Val Ala Asn 
                885                 890                 895     


Glu Arg Asn Asn Leu Ala Leu Gly Asn Thr Lys Glu Leu His Glu Thr 
            900                 905                 910         


Asp Leu Thr Cys Val Asn Glu Pro Ile Phe Lys Asn Ser Thr Met Val 
        915                 920                 925             


Leu Tyr Gly Asp Thr Gly Asp Lys Gln Ala Thr Gln Val Ser Ile Lys 
    930                 935                 940                 


Lys Asp Leu Val Tyr Val Leu Ala Glu Glu Asn Lys Asn Ser Val Lys 
945                 950                 955                 960 


Gln His Ile Lys Met Thr Leu Gly Gln Asp Leu Lys Ser Asp Ile Ser 
                965                 970                 975     


Leu Asn Ile Asp Lys Ile Pro Glu Lys Asn Asn Asp Tyr Met Asn Lys 
            980                 985                 990         


Trp Ala Gly Leu Leu Gly Pro Ile  Ser Asn His Ser Phe  Gly Gly Ser 
        995                 1000                 1005             


Phe Arg  Thr Ala Ser Asn Lys  Glu Ile Lys Leu Ser  Glu His Asn 
    1010                 1015                 1020             


Ile Lys  Lys Ser Lys Met Phe  Phe Lys Asp Ile Glu  Glu Gln Tyr 
    1025                 1030                 1035             


Pro Thr  Ser Leu Ala Cys Val  Glu Ile Val Asn Thr  Leu Ala Leu 
    1040                 1045                 1050             


Asp Asn  Gln Lys Lys Leu Ser  Lys Pro Gln Ser Ile  Asn Thr Val 
    1055                 1060                 1065             


Ser Ala  His Leu Gln Ser Ser  Val Val Val Ser Asp  Cys Lys Asn 
    1070                 1075                 1080             


Ser His  Ile Thr Pro Gln Met  Leu Phe Ser Lys Gln  Asp Phe Asn 
    1085                 1090                 1095             


Ser Asn  His Asn Leu Thr Pro  Ser Gln Lys Ala Glu  Ile Thr Glu 
    1100                 1105                 1110             


Leu Ser  Thr Ile Leu Glu Glu  Ser Gly Ser Gln Phe  Glu Phe Thr 
    1115                 1120                 1125             


Gln Phe  Arg Lys Pro Ser Tyr  Ile Leu Gln Lys Ser  Thr Phe Glu 
    1130                 1135                 1140             


Val Pro  Glu Asn Gln Met Thr  Ile Leu Lys Thr Thr  Ser Glu Glu 
    1145                 1150                 1155             


Cys Arg  Asp Ala Asp Leu His  Val Ile Met Asn Ala  Pro Ser Ile 
    1160                 1165                 1170             


Gly Gln  Val Asp Ser Ser Lys  Gln Phe Glu Gly Thr  Val Glu Ile 
    1175                 1180                 1185             


Lys Arg  Lys Phe Ala Gly Leu  Leu Lys Asn Asp Cys  Asn Lys Ser 
    1190                 1195                 1200             


Ala Ser  Gly Tyr Leu Thr Asp  Glu Asn Glu Val Gly  Phe Arg Gly 
    1205                 1210                 1215             


Phe Tyr  Ser Ala His Gly Thr  Lys Leu Asn Val Ser  Thr Glu Ala 
    1220                 1225                 1230             


Leu Gln  Lys Ala Val Lys Leu  Phe Ser Asp Ile Glu  Asn Ile Ser 
    1235                 1240                 1245             


Glu Glu  Thr Ser Ala Glu Val  His Pro Ile Ser Leu  Ser Ser Ser 
    1250                 1255                 1260             


Lys Cys  His Asp Ser Val Val  Ser Met Phe Lys Ile  Glu Asn His 
    1265                 1270                 1275             


Asn Asp  Lys Thr Val Ser Glu  Lys Asn Asn Lys Cys  Gln Leu Ile 
    1280                 1285                 1290             


Leu Gln  Asn Asn Ile Glu Met  Thr Thr Gly Thr Phe  Val Glu Glu 
    1295                 1300                 1305             


Ile Thr  Glu Asn Tyr Lys Arg  Asn Thr Glu Asn Glu  Asp Asn Lys 
    1310                 1315                 1320             


Tyr Thr  Ala Ala Ser Arg Asn  Ser His Asn Leu Glu  Phe Asp Gly 
    1325                 1330                 1335             


Ser Asp  Ser Ser Lys Asn Asp  Thr Val Cys Ile His  Lys Asp Glu 
    1340                 1345                 1350             


Thr Asp  Leu Leu Phe Thr Asp  Gln His Asn Ile Cys  Leu Lys Leu 
    1355                 1360                 1365             


Ser Gly  Gln Phe Met Lys Glu  Gly Asn Thr Gln Ile  Lys Glu Asp 
    1370                 1375                 1380             


Leu Ser  Asp Leu Thr Phe Leu  Glu Val Ala Lys Ala  Gln Glu Ala 
    1385                 1390                 1395             


Cys His  Gly Asn Thr Ser Asn  Lys Glu Gln Leu Thr  Ala Thr Lys 
    1400                 1405                 1410             


Thr Glu  Gln Asn Ile Lys Asp  Phe Glu Thr Ser Asp  Thr Phe Phe 
    1415                 1420                 1425             


Gln Thr  Ala Ser Gly Lys Asn  Ile Ser Val Ala Lys  Glu Ser Phe 
    1430                 1435                 1440             


Asn Lys  Ile Val Asn Phe Phe  Asp Gln Lys Pro Glu  Glu Leu His 
    1445                 1450                 1455             


Asn Phe  Ser Leu Asn Ser Glu  Leu His Ser Asp Ile  Arg Lys Asn 
    1460                 1465                 1470             


Lys Met  Asp Ile Leu Ser Tyr  Glu Glu Thr Asp Ile  Val Lys His 
    1475                 1480                 1485             


Lys Ile  Leu Lys Glu Ser Val  Pro Val Gly Thr Gly  Asn Gln Leu 
    1490                 1495                 1500             


Val Thr  Phe Gln Gly Gln Pro  Glu Arg Asp Glu Lys  Ile Lys Glu 
    1505                 1510                 1515             


Pro Thr  Leu Leu Gly Phe His  Thr Ala Ser Gly Lys  Lys Val Lys 
    1520                 1525                 1530             


Ile Ala  Lys Glu Ser Leu Asp  Lys Val Lys Asn Leu  Phe Asp Glu 
    1535                 1540                 1545             


Lys Glu  Gln Gly Thr Ser Glu  Ile Thr Ser Phe Ser  His Gln Trp 
    1550                 1555                 1560             


Ala Lys  Thr Leu Lys Tyr Arg  Glu Ala Cys Lys Asp  Leu Glu Leu 
    1565                 1570                 1575             


Ala Cys  Glu Thr Ile Glu Ile  Thr Ala Ala Pro Lys  Cys Lys Glu 
    1580                 1585                 1590             


Met Gln  Asn Ser Leu Asn Asn  Asp Lys Asn Leu Val  Ser Ile Glu 
    1595                 1600                 1605             


Thr Val  Val Pro Pro Lys Leu  Leu Ser Asp Asn Leu  Cys Arg Gln 
    1610                 1615                 1620             


Thr Glu  Asn Leu Lys Thr Ser  Lys Ser Ile Phe Leu  Lys Val Lys 
    1625                 1630                 1635             


Val His  Glu Asn Val Glu Lys  Glu Thr Ala Lys Ser  Pro Ala Thr 
    1640                 1645                 1650             


Cys Tyr  Thr Asn Gln Ser Pro  Tyr Ser Val Ile Glu  Asn Ser Ala 
    1655                 1660                 1665             


Leu Ala  Phe Tyr Thr Ser Cys  Ser Arg Lys Thr Ser  Val Ser Gln 
    1670                 1675                 1680             


Thr Ser  Leu Leu Glu Ala Lys  Lys Trp Leu Arg Glu  Gly Ile Phe 
    1685                 1690                 1695             


Asp Gly  Gln Pro Glu Arg Ile  Asn Thr Ala Asp Tyr  Val Gly Asn 
    1700                 1705                 1710             


Tyr Leu  Tyr Glu Asn Asn Ser  Asn Ser Thr Ile Ala  Glu Asn Asp 
    1715                 1720                 1725             


Lys Asn  His Leu Ser Glu Lys  Gln Asp Thr Tyr Leu  Ser Asn Ser 
    1730                 1735                 1740             


Ser Met  Ser Asn Ser Tyr Ser  Tyr His Ser Asp Glu  Val Tyr Asn 
    1745                 1750                 1755             


Asp Ser  Gly Tyr Leu Ser Lys  Asn Lys Leu Asp Ser  Gly Ile Glu 
    1760                 1765                 1770             


Pro Val  Leu Lys Asn Val Glu  Asp Gln Lys Asn Thr  Ser Phe Ser 
    1775                 1780                 1785             


Lys Val  Ile Ser Asn Val Lys  Asp Ala Asn Ala Tyr  Pro Gln Thr 
    1790                 1795                 1800             


Val Asn  Glu Asp Ile Cys Val  Glu Glu Leu Val Thr  Ser Ser Ser 
    1805                 1810                 1815             


Pro Cys  Lys Asn Lys Asn Ala  Ala Ile Lys Leu Ser  Ile Ser Asn 
    1820                 1825                 1830             


Ser Asn  Asn Phe Glu Val Gly  Pro Pro Ala Phe Arg  Ile Ala Ser 
    1835                 1840                 1845             


Gly Lys  Ile Val Cys Val Ser  His Glu Thr Ile Lys  Lys Val Lys 
    1850                 1855                 1860             


Asp Ile  Phe Thr Asp Ser Phe  Ser Lys Val Ile Lys  Glu Asn Asn 
    1865                 1870                 1875             


Glu Asn  Lys Ser Lys Ile Cys  Gln Thr Lys Ile Met  Ala Gly Cys 
    1880                 1885                 1890             


Tyr Glu  Ala Leu Asp Asp Ser  Glu Asp Ile Leu His  Asn Ser Leu 
    1895                 1900                 1905             


Asp Asn  Asp Glu Cys Ser Thr  His Ser His Lys Val  Phe Ala Asp 
    1910                 1915                 1920             


Ile Gln  Ser Glu Glu Ile Leu  Gln His Asn Gln Asn  Met Ser Gly 
    1925                 1930                 1935             


Leu Glu  Lys Val Ser Lys Ile  Ser Pro Cys Asp Val  Ser Leu Glu 
    1940                 1945                 1950             


Thr Ser  Asp Ile Cys Lys Cys  Ser Ile Gly Lys Leu  His Lys Ser 
    1955                 1960                 1965             


Val Ser  Ser Ala Asn Thr Cys  Gly Ile Phe Ser Thr  Ala Ser Gly 
    1970                 1975                 1980             


Lys Ser  Val Gln Val Ser Asp  Ala Ser Leu Gln Asn  Ala Arg Gln 
    1985                 1990                 1995             


Val Phe  Ser Glu Ile Glu Asp  Ser Thr Lys Gln Val  Phe Ser Lys 
    2000                 2005                 2010             


Val Leu  Phe Lys Ser Asn Glu  His Ser Asp Gln Leu  Thr Arg Glu 
    2015                 2020                 2025             


Glu Asn  Thr Ala Ile Arg Thr  Pro Glu His Leu Ile  Ser Gln Lys 
    2030                 2035                 2040             


Gly Phe  Ser Tyr Asn Val Val  Asn Ser Ser Ala Phe  Ser Gly Phe 
    2045                 2050                 2055             


Ser Thr  Ala Ser Gly Lys Gln  Val Ser Ile Leu Glu  Ser Ser Leu 
    2060                 2065                 2070             


His Lys  Val Lys Gly Val Leu  Glu Glu Phe Asp Leu  Ile Arg Thr 
    2075                 2080                 2085             


Glu His  Ser Leu His Tyr Ser  Pro Thr Ser Arg Gln  Asn Val Ser 
    2090                 2095                 2100             


Lys Ile  Leu Pro Arg Val Asp  Lys Arg Asn Pro Glu  His Cys Val 
    2105                 2110                 2115             


Asn Ser  Glu Met Glu Lys Thr  Cys Ser Lys Glu Phe  Lys Leu Ser 
    2120                 2125                 2130             


Asn Asn  Leu Asn Val Glu Gly  Gly Ser Ser Glu Asn  Asn His Ser 
    2135                 2140                 2145             


Ile Lys  Val Ser Pro Tyr Leu  Ser Gln Phe Gln Gln  Asp Lys Gln 
    2150                 2155                 2160             


Gln Leu  Val Leu Gly Thr Lys  Val Ser Leu Val Glu  Asn Ile His 
    2165                 2170                 2175             


Val Leu  Gly Lys Glu Gln Ala  Ser Pro Lys Asn Val  Lys Met Glu 
    2180                 2185                 2190             


Ile Gly  Lys Thr Glu Thr Phe  Ser Asp Val Pro Val  Lys Thr Asn 
    2195                 2200                 2205             


Ile Glu  Val Cys Ser Thr Tyr  Ser Lys Asp Ser Glu  Asn Tyr Phe 
    2210                 2215                 2220             


Glu Thr  Glu Ala Val Glu Ile  Ala Lys Ala Phe Met  Glu Asp Asp 
    2225                 2230                 2235             


Glu Leu  Thr Asp Ser Lys Leu  Pro Ser His Ala Thr  His Ser Leu 
    2240                 2245                 2250             


Phe Thr  Cys Pro Glu Asn Glu  Glu Met Val Leu Ser  Asn Ser Arg 
    2255                 2260                 2265             


Ile Gly  Lys Arg Arg Gly Glu  Pro Leu Ile Leu Val  Gly Glu Pro 
    2270                 2275                 2280             


Ser Ile  Lys Arg Asn Leu Leu  Asn Glu Phe Asp Arg  Ile Ile Glu 
    2285                 2290                 2295             


Asn Gln  Glu Lys Ser Leu Lys  Ala Ser Lys Ser Thr  Pro Asp Gly 
    2300                 2305                 2310             


Thr Ile  Lys Asp Arg Arg Leu  Phe Met His His Val  Ser Leu Glu 
    2315                 2320                 2325             


Pro Ile  Thr Cys Val Pro Phe  Arg Thr Thr Lys Glu  Arg Gln Glu 
    2330                 2335                 2340             


Ile Gln  Asn Pro Asn Phe Thr  Ala Pro Gly Gln Glu  Phe Leu Ser 
    2345                 2350                 2355             


Lys Ser  His Leu Tyr Glu His  Leu Thr Leu Glu Lys  Ser Ser Ser 
    2360                 2365                 2370             


Asn Leu  Ala Val Ser Gly His  Pro Phe Tyr Gln Val  Ser Ala Thr 
    2375                 2380                 2385             


Arg Asn  Glu Lys Met Arg His  Leu Ile Thr Thr Gly  Arg Pro Thr 
    2390                 2395                 2400             


Lys Val  Phe Val Pro Pro Phe  Lys Thr Lys Ser His  Phe His Arg 
    2405                 2410                 2415             


Val Glu  Gln Cys Val Arg Asn  Ile Asn Leu Glu Glu  Asn Arg Gln 
    2420                 2425                 2430             


Lys Gln  Asn Ile Asp Gly His  Gly Ser Asp Asp Ser  Lys Asn Lys 
    2435                 2440                 2445             


Ile Asn  Asp Asn Glu Ile His  Gln Phe Asn Lys Asn  Asn Ser Asn 
    2450                 2455                 2460             


Gln Ala  Ala Ala Val Thr Phe  Thr Lys Cys Glu Glu  Glu Pro Leu 
    2465                 2470                 2475             


Asp Leu  Ile Thr Ser Leu Gln  Asn Ala Arg Asp Ile  Gln Asp Met 
    2480                 2485                 2490             


Arg Ile  Lys Lys Lys Gln Arg  Gln Arg Val Phe Pro  Gln Pro Gly 
    2495                 2500                 2505             


Ser Leu  Tyr Leu Ala Lys Thr  Ser Thr Leu Pro Arg  Ile Ser Leu 
    2510                 2515                 2520             


Lys Ala  Ala Val Gly Gly Gln  Val Pro Ser Ala Cys  Ser His Lys 
    2525                 2530                 2535             


Gln Leu  Tyr Thr Tyr Gly Val  Ser Lys His Cys Ile  Lys Ile Asn 
    2540                 2545                 2550             


Ser Lys  Asn Ala Glu Ser Phe  Gln Phe His Thr Glu  Asp Tyr Phe 
    2555                 2560                 2565             


Gly Lys  Glu Ser Leu Trp Thr  Gly Lys Gly Ile Gln  Leu Ala Asp 
    2570                 2575                 2580             


Gly Gly  Trp Leu Ile Pro Ser  Asn Asp Gly Lys Ala  Gly Lys Glu 
    2585                 2590                 2595             


Glu Phe  Tyr Arg Ala Leu Cys  Asp Thr Pro Gly Val  Asp Pro Lys 
    2600                 2605                 2610             


Leu Ile  Ser Arg Ile Trp Val  Tyr Asn His Tyr Arg  Trp Ile Ile 
    2615                 2620                 2625             


Trp Lys  Leu Ala Ala Met Glu  Cys Ala Phe Pro Lys  Glu Phe Ala 
    2630                 2635                 2640             


Asn Arg  Cys Leu Ser Pro Glu  Arg Val Leu Leu Gln  Leu Lys Tyr 
    2645                 2650                 2655             


Arg Tyr  Asp Thr Glu Ile Asp  Arg Ser Arg Arg Ser  Ala Ile Lys 
    2660                 2665                 2670             


Lys Ile  Met Glu Arg Asp Asp  Thr Ala Ala Lys Thr  Leu Val Leu 
    2675                 2680                 2685             


Cys Val  Ser Asp Ile Ile Ser  Leu Ser Ala Asn Ile  Ser Glu Thr 
    2690                 2695                 2700             


Ser Ser  Asn Lys Thr Ser Ser  Ala Asp Thr Gln Lys  Val Ala Ile 
    2705                 2710                 2715             


Ile Glu  Leu Thr Asp Gly Trp  Tyr Ala Val Lys Ala  Gln Leu Asp 
    2720                 2725                 2730             


Pro Pro  Leu Leu Ala Val Leu  Lys Asn Gly Arg Leu  Thr Val Gly 
    2735                 2740                 2745             


Gln Lys  Ile Ile Leu His Gly  Ala Glu Leu Val Gly  Ser Pro Asp 
    2750                 2755                 2760             


Ala Cys  Thr Pro Leu Glu Ala  Pro Glu Ser Leu Met  Leu Lys Ile 
    2765                 2770                 2775             


Ser Ala  Asn Ser Thr Arg Pro  Ala Arg Trp Tyr Thr  Lys Leu Gly 
    2780                 2785                 2790             


Phe Phe  Pro Asp Pro Arg Pro  Phe Pro Leu Pro Leu  Ser Ser Leu 
    2795                 2800                 2805             


Phe Ser  Asp Gly Gly Asn Val  Gly Cys Val Asp Val  Ile Ile Gln 
    2810                 2815                 2820             


Arg Ala  Tyr Pro Ile Gln Trp  Met Glu Lys Thr Ser  Ser Gly Leu 
    2825                 2830                 2835             


Tyr Ile  Phe Arg Asn Glu Arg  Glu Glu Glu Lys Glu  Ala Ala Lys 
    2840                 2845                 2850             


Tyr Val  Glu Ala Gln Gln Lys  Arg Leu Glu Ala Leu  Phe Thr Lys 
    2855                 2860                 2865             


Ile Gln  Glu Glu Phe Glu Glu  His Glu Glu Asn Thr  Thr Lys Pro 
    2870                 2875                 2880             


Tyr Leu  Pro Ser Arg Ala Leu  Thr Arg Gln Gln Val  Arg Ala Leu 
    2885                 2890                 2895             


Gln Asp  Gly Ala Glu Leu Tyr  Glu Ala Val Lys Asn  Ala Ala Asp 
    2900                 2905                 2910             


Pro Ala  Tyr Leu Glu Gly Tyr  Phe Ser Glu Glu Gln  Leu Arg Ala 
    2915                 2920                 2925             


Leu Asn  Asn His Arg Gln Met  Leu Asn Asp Lys Lys  Gln Ala Gln 
    2930                 2935                 2940             


Ile Gln  Leu Glu Ile Arg Lys  Ala Met Glu Ser Ala  Glu Gln Lys 
    2945                 2950                 2955             


Glu Gln  Gly Leu Ser Arg Asp  Val Thr Thr Val Trp  Lys Leu Arg 
    2960                 2965                 2970             


Ile Val  Ser Tyr Ser Lys Lys  Glu Lys Asp Ser Val  Ile Leu Ser 
    2975                 2980                 2985             


Ile Trp  Arg Pro Ser Ser Asp  Leu Tyr Ser Leu Leu  Thr Glu Gly 
    2990                 2995                 3000             


Lys Arg  Tyr Arg Ile Tyr His  Leu Ala Thr Ser Lys  Ser Lys Ser 
    3005                 3010                 3015             


Lys Ser  Glu Arg Ala Asn Ile  Gln Leu Ala Ala Thr  Lys Lys Thr 
    3020                 3025                 3030             


Gln Tyr  Gln Gln Leu Pro Val  Ser Asp Glu Ile Leu  Phe Gln Ile 
    3035                 3040                 3045             


Tyr Gln  Pro Arg Glu Pro Leu  His Phe Ser Lys Phe  Leu Asp Pro 
    3050                 3055                 3060             


Asp Phe  Gln Pro Ser Cys Ser  Glu Val Asp Leu Ile  Gly Phe Val 
    3065                 3070                 3075             


Val Ser  Val Val Lys Lys Thr  Gly Leu Ala Pro Phe  Val Tyr Leu 
    3080                 3085                 3090             


Ser Asp  Glu Cys Tyr Asn Leu  Leu Ala Ile Lys Phe  Trp Ile Asp 
    3095                 3100                 3105             


Leu Asn  Glu Asp Ile Ile Lys  Pro His Met Leu Ile  Ala Ala Ser 
    3110                 3115                 3120             


Asn Leu  Gln Trp Arg Pro Glu  Ser Lys Ser Gly Leu  Leu Thr Leu 
    3125                 3130                 3135             


Phe Ala  Gly Asp Phe Ser Val  Phe Ser Ala Ser Pro  Lys Glu Gly 
    3140                 3145                 3150             


His Phe  Gln Glu Thr Phe Asn  Lys Met Lys Asn Thr  Val Glu Asn 
    3155                 3160                 3165             


Ile Asp  Ile Leu Cys Asn Glu  Ala Glu Asn Lys Leu  Met His Ile 
    3170                 3175                 3180             


Leu His  Ala Asn Asp Pro Lys  Trp Ser Thr Pro Thr  Lys Asp Cys 
    3185                 3190                 3195             


Thr Ser  Gly Pro Tyr Thr Ala  Gln Ile Ile Pro Gly  Thr Gly Asn 
    3200                 3205                 3210             


Lys Leu  Leu Met Ser Ser Pro  Asn Cys Glu Ile Tyr  Tyr Gln Ser 
    3215                 3220                 3225             


Pro Leu  Ser Leu Cys Met Ala  Lys Arg Lys Ser Val  Ser Thr Pro 
    3230                 3235                 3240             


Val Ser  Ala Gln Met Thr Ser  Lys Ser Cys Lys Gly  Glu Lys Glu 
    3245                 3250                 3255             


Ile Asp  Asp Gln Lys Asn Cys  Lys Lys Arg Arg Ala  Leu Asp Phe 
    3260                 3265                 3270             


Leu Ser  Arg Leu Pro Leu Pro  Pro Pro Val Ser Pro  Ile Cys Thr 
    3275                 3280                 3285             


Phe Val  Ser Pro Ala Ala Gln  Lys Ala Phe Gln Pro  Pro Arg Ser 
    3290                 3295                 3300             


Cys Gly  Thr Lys Tyr Glu Thr  Pro Ile Lys Lys Lys  Glu Leu Asn 
    3305                 3310                 3315             


Ser Pro  Gln Met Thr Pro Phe  Lys Lys Phe Asn Glu  Ile Ser Leu 
    3320                 3325                 3330             


Leu Glu  Ser Asn Ser Ile Ala  Asp Glu Glu Leu Ala  Leu Ile Asn 
    3335                 3340                 3345             


Thr Gln  Ala Leu Leu Ser Gly  Ser Thr Gly Glu Lys  Gln Phe Ile 
    3350                 3355                 3360             


Ser Val  Ser Glu Ser Thr Arg  Thr Ala Pro Thr Ser  Ser Glu Asp 
    3365                 3370                 3375             


Tyr Leu  Arg Leu Lys Arg Arg  Cys Thr Thr Ser Leu  Ile Lys Glu 
    3380                 3385                 3390             


Gln Glu  Ser Ser Gln Ala Ser  Thr Glu Glu Cys Glu  Lys Asn Lys 
    3395                 3400                 3405             


Gln Asp  Thr Ile Thr Thr Lys  Lys Tyr Ile 
    3410                 3415             


<210>  7
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 


Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     


Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         


Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 
        275                 280                 285             


Leu His Glu Pro Phe Leu Lys Val Pro 
    290                 295         


<210>  8
<211>  1017
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Met Ser Glu Gly Lys Pro Pro Asp Lys Lys Arg Pro Arg Arg Ser 
1               5                   10                  15      


Leu Ser Ile Ser Lys Asn Lys Lys Lys Ala Ser Asn Ser Ile Ile Ser 
            20                  25                  30          


Cys Phe Asn Asn Ala Pro Pro Ala Lys Leu Ala Cys Pro Val Cys Ser 
        35                  40                  45              


Lys Met Val Pro Arg Tyr Asp Leu Asn Arg His Leu Asp Glu Met Cys 
    50                  55                  60                  


Ala Asn Asn Asp Phe Val Gln Val Asp Pro Gly Gln Val Gly Leu Ile 
65                  70                  75                  80  


Asn Ser Asn Val Ser Met Val Asp Leu Thr Ser Val Thr Leu Glu Asp 
                85                  90                  95      


Val Thr Pro Lys Lys Ser Pro Pro Pro Lys Thr Asn Leu Thr Pro Gly 
            100                 105                 110         


Gln Ser Asp Ser Ala Lys Arg Glu Val Lys Gln Lys Ile Ser Pro Tyr 
        115                 120                 125             


Phe Lys Ser Asn Asp Val Val Cys Lys Asn Gln Asp Glu Leu Arg Asn 
    130                 135                 140                 


Arg Ser Val Lys Val Ile Cys Leu Gly Ser Leu Ala Ser Lys Leu Ser 
145                 150                 155                 160 


Arg Lys Tyr Val Lys Ala Lys Lys Ser Ile Asp Lys Asp Glu Glu Phe 
                165                 170                 175     


Ala Gly Ser Ser Pro Gln Ser Ser Lys Ser Thr Val Val Lys Ser Leu 
            180                 185                 190         


Ile Asp Asn Ser Ser Glu Ile Glu Asp Glu Asp Gln Ile Leu Glu Asn 
        195                 200                 205             


Ser Ser Gln Lys Glu Asn Val Phe Lys Cys Asp Ser Leu Lys Glu Glu 
    210                 215                 220                 


Cys Ile Pro Glu His Met Val Arg Gly Ser Lys Ile Met Glu Ala Glu 
225                 230                 235                 240 


Ser Gln Lys Ala Thr Arg Glu Cys Glu Lys Ser Ala Leu Thr Pro Gly 
                245                 250                 255     


Phe Ser Asp Asn Ala Ile Met Leu Phe Ser Pro Asp Phe Thr Leu Arg 
            260                 265                 270         


Asn Thr Leu Lys Ser Thr Ser Glu Asp Ser Leu Val Lys Gln Glu Cys 
        275                 280                 285             


Ile Lys Glu Val Val Glu Lys Arg Glu Ala Cys His Cys Glu Glu Val 
    290                 295                 300                 


Lys Met Thr Val Ala Ser Glu Ala Lys Ile Gln Leu Ser Asp Ser Glu 
305                 310                 315                 320 


Ala Lys Ser His Ser Ser Ala Asp Asp Ala Ser Ala Trp Ser Asn Ile 
                325                 330                 335     


Gln Glu Ala Pro Leu Gln Asp Asp Ser Cys Leu Asn Asn Asp Ile Pro 
            340                 345                 350         


His Ser Ile Pro Leu Glu Gln Gly Ser Ser Cys Asn Gly Pro Gly Gln 
        355                 360                 365             


Thr Thr Gly His Pro Tyr Tyr Leu Arg Ser Phe Leu Val Val Leu Lys 
    370                 375                 380                 


Thr Val Leu Glu Asn Glu Asp Asp Met Leu Leu Phe Asp Glu Gln Glu 
385                 390                 395                 400 


Lys Gly Ile Val Thr Lys Phe Tyr Gln Leu Ser Ala Thr Gly Gln Lys 
                405                 410                 415     


Leu Tyr Val Arg Leu Phe Gln Arg Lys Leu Ser Trp Ile Lys Met Thr 
            420                 425                 430         


Lys Leu Glu Tyr Glu Glu Ile Ala Leu Asp Leu Thr Pro Val Ile Glu 
        435                 440                 445             


Glu Leu Thr Asn Ala Gly Phe Leu Gln Thr Glu Ser Glu Leu Gln Glu 
    450                 455                 460                 


Leu Ser Glu Val Leu Glu Leu Leu Ser Ala Pro Glu Leu Lys Ser Leu 
465                 470                 475                 480 


Ala Lys Thr Phe His Leu Val Asn Pro Asn Gly Gln Lys Gln Gln Leu 
                485                 490                 495     


Val Asp Ala Phe Leu Lys Leu Ala Lys Gln Arg Ser Val Cys Thr Trp 
            500                 505                 510         


Gly Lys Asn Lys Pro Gly Ile Gly Ala Val Ile Leu Lys Arg Ala Lys 
        515                 520                 525             


Ala Leu Ala Gly Gln Ser Val Arg Ile Cys Lys Gly Pro Arg Ala Val 
    530                 535                 540                 


Phe Ser Arg Ile Leu Leu Leu Phe Ser Leu Thr Asp Ser Met Glu Asp 
545                 550                 555                 560 


Glu Asp Ala Ala Cys Gly Gly Gln Gly Gln Leu Ser Thr Val Leu Leu 
                565                 570                 575     


Val Asn Leu Gly Arg Met Glu Phe Pro Ser Tyr Thr Ile Asn Arg Lys 
            580                 585                 590         


Thr His Ile Phe Gln Asp Arg Asp Asp Leu Ile Arg Tyr Ala Ala Ala 
        595                 600                 605             


Thr His Met Leu Ser Asp Ile Ser Ser Ala Met Ala Asn Gly Asn Trp 
    610                 615                 620                 


Glu Glu Ala Lys Glu Leu Ala Gln Cys Ala Lys Arg Asp Trp Asn Arg 
625                 630                 635                 640 


Leu Lys Asn His Pro Ser Leu Arg Cys His Glu Asp Leu Pro Leu Phe 
                645                 650                 655     


Leu Arg Cys Phe Thr Val Gly Trp Ile Tyr Thr Arg Ile Leu Ser Arg 
            660                 665                 670         


Phe Val Glu Ile Leu Gln Arg Leu His Met Tyr Glu Glu Ala Val Arg 
        675                 680                 685             


Glu Leu Glu Ser Leu Leu Ser Gln Arg Ile Tyr Cys Pro Asp Ser Arg 
    690                 695                 700                 


Gly Arg Trp Trp Asp Arg Leu Ala Leu Asn Leu His Gln His Leu Lys 
705                 710                 715                 720 


Arg Leu Glu Pro Thr Ile Lys Cys Ile Thr Glu Gly Leu Ala Asp Pro 
                725                 730                 735     


Glu Val Arg Thr Gly His Arg Leu Ser Leu Tyr Gln Arg Ala Val Arg 
            740                 745                 750         


Leu Arg Glu Ser Pro Ser Cys Lys Lys Phe Lys His Leu Phe Gln Gln 
        755                 760                 765             


Leu Pro Glu Met Ala Val Gln Asp Val Lys His Val Thr Ile Thr Gly 
    770                 775                 780                 


Arg Leu Cys Pro Gln Arg Gly Met Cys Lys Ser Val Phe Val Met Glu 
785                 790                 795                 800 


Ala Gly Glu Ala Ala Asp Pro Thr Thr Val Leu Cys Ser Val Glu Glu 
                805                 810                 815     


Leu Ala Leu Ala His Tyr Arg Arg Ser Gly Phe Asp Gln Gly Ile His 
            820                 825                 830         


Gly Glu Gly Ser Thr Phe Ser Thr Leu Tyr Gly Leu Leu Leu Trp Asp 
        835                 840                 845             


Ile Ile Phe Met Asp Gly Ile Pro Asp Val Phe Arg Asn Ala Cys Gln 
    850                 855                 860                 


Ala Phe Pro Leu Asp Leu Cys Thr Asp Ser Phe Phe Thr Ser Arg Arg 
865                 870                 875                 880 


Pro Ala Leu Glu Ala Arg Leu Gln Leu Ile His Asp Ala Pro Glu Glu 
                885                 890                 895     


Ser Leu Arg Ala Trp Val Ala Ala Thr Trp His Glu Gln Glu Gly Arg 
            900                 905                 910         


Val Ala Ser Leu Val Ser Trp Asp Arg Phe Thr Ser Leu Gln Gln Ala 
        915                 920                 925             


Gln Asp Leu Val Ser Cys Leu Gly Gly Pro Val Leu Ser Gly Val Cys 
    930                 935                 940                 


Arg His Leu Ala Ala Asp Phe Arg His Cys Arg Gly Gly Leu Pro Asp 
945                 950                 955                 960 


Leu Val Val Trp Asn Ser Gln Ser Arg His Phe Lys Leu Val Glu Val 
                965                 970                 975     


Lys Gly Pro Asn Asp Arg Leu Ser His Lys Gln Met Ile Trp Leu Ala 
            980                 985                 990         


Glu Leu Gln Lys Leu Gly Ala Glu  Val Glu Val Cys His  Val Val Ala 
        995                 1000                 1005             


Val Gly  Ala Lys Ser Gln Ser  Leu Ser 
    1010                 1015         


<210>  9
<211>  862
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Arg Ala Glu Ser Ser Ser Thr Glu Pro Ala Lys Ala Ile Lys 
1               5                   10                  15      


Pro Ile Asp Arg Lys Ser Val His Gln Ile Cys Ser Gly Gln Val Val 
            20                  25                  30          


Leu Ser Leu Ser Thr Ala Val Lys Glu Leu Val Glu Asn Ser Leu Asp 
        35                  40                  45              


Ala Gly Ala Thr Asn Ile Asp Leu Lys Leu Lys Asp Tyr Gly Val Asp 
    50                  55                  60                  


Leu Ile Glu Val Ser Asp Asn Gly Cys Gly Val Glu Glu Glu Asn Phe 
65                  70                  75                  80  


Glu Gly Leu Thr Leu Lys His His Thr Ser Lys Ile Gln Glu Phe Ala 
                85                  90                  95      


Asp Leu Thr Gln Val Glu Thr Phe Gly Phe Arg Gly Glu Ala Leu Ser 
            100                 105                 110         


Ser Leu Cys Ala Leu Ser Asp Val Thr Ile Ser Thr Cys His Ala Ser 
        115                 120                 125             


Ala Lys Val Gly Thr Arg Leu Met Phe Asp His Asn Gly Lys Ile Ile 
    130                 135                 140                 


Gln Lys Thr Pro Tyr Pro Arg Pro Arg Gly Thr Thr Val Ser Val Gln 
145                 150                 155                 160 


Gln Leu Phe Ser Thr Leu Pro Val Arg His Lys Glu Phe Gln Arg Asn 
                165                 170                 175     


Ile Lys Lys Glu Tyr Ala Lys Met Val Gln Val Leu His Ala Tyr Cys 
            180                 185                 190         


Ile Ile Ser Ala Gly Ile Arg Val Ser Cys Thr Asn Gln Leu Gly Gln 
        195                 200                 205             


Gly Lys Arg Gln Pro Val Val Cys Thr Gly Gly Ser Pro Ser Ile Lys 
    210                 215                 220                 


Glu Asn Ile Gly Ser Val Phe Gly Gln Lys Gln Leu Gln Ser Leu Ile 
225                 230                 235                 240 


Pro Phe Val Gln Leu Pro Pro Ser Asp Ser Val Cys Glu Glu Tyr Gly 
                245                 250                 255     


Leu Ser Cys Ser Asp Ala Leu His Asn Leu Phe Tyr Ile Ser Gly Phe 
            260                 265                 270         


Ile Ser Gln Cys Thr His Gly Val Gly Arg Ser Ser Thr Asp Arg Gln 
        275                 280                 285             


Phe Phe Phe Ile Asn Arg Arg Pro Cys Asp Pro Ala Lys Val Cys Arg 
    290                 295                 300                 


Leu Val Asn Glu Val Tyr His Met Tyr Asn Arg His Gln Tyr Pro Phe 
305                 310                 315                 320 


Val Val Leu Asn Ile Ser Val Asp Ser Glu Cys Val Asp Ile Asn Val 
                325                 330                 335     


Thr Pro Asp Lys Arg Gln Ile Leu Leu Gln Glu Glu Lys Leu Leu Leu 
            340                 345                 350         


Ala Val Leu Lys Thr Ser Leu Ile Gly Met Phe Asp Ser Asp Val Asn 
        355                 360                 365             


Lys Leu Asn Val Ser Gln Gln Pro Leu Leu Asp Val Glu Gly Asn Leu 
    370                 375                 380                 


Ile Lys Met His Ala Ala Asp Leu Glu Lys Pro Met Val Glu Lys Gln 
385                 390                 395                 400 


Asp Gln Ser Pro Ser Leu Arg Thr Gly Glu Glu Lys Lys Asp Val Ser 
                405                 410                 415     


Ile Ser Arg Leu Arg Glu Ala Phe Ser Leu Arg His Thr Thr Glu Asn 
            420                 425                 430         


Lys Pro His Ser Pro Lys Thr Pro Glu Pro Arg Arg Ser Pro Leu Gly 
        435                 440                 445             


Gln Lys Arg Gly Met Leu Ser Ser Ser Thr Ser Gly Ala Ile Ser Asp 
    450                 455                 460                 


Lys Gly Val Leu Arg Pro Gln Lys Glu Ala Val Ser Ser Ser His Gly 
465                 470                 475                 480 


Pro Ser Asp Pro Thr Asp Arg Ala Glu Val Glu Lys Asp Ser Gly His 
                485                 490                 495     


Gly Ser Thr Ser Val Asp Ser Glu Gly Phe Ser Ile Pro Asp Thr Gly 
            500                 505                 510         


Ser His Cys Ser Ser Glu Tyr Ala Ala Ser Ser Pro Gly Asp Arg Gly 
        515                 520                 525             


Ser Gln Glu His Val Asp Ser Gln Glu Lys Ala Pro Glu Thr Asp Asp 
    530                 535                 540                 


Ser Phe Ser Asp Val Asp Cys His Ser Asn Gln Glu Asp Thr Gly Cys 
545                 550                 555                 560 


Lys Phe Arg Val Leu Pro Gln Pro Thr Asn Leu Ala Thr Pro Asn Thr 
                565                 570                 575     


Lys Arg Phe Lys Lys Glu Glu Ile Leu Ser Ser Ser Asp Ile Cys Gln 
            580                 585                 590         


Lys Leu Val Asn Thr Gln Asp Met Ser Ala Ser Gln Val Asp Val Ala 
        595                 600                 605             


Val Lys Ile Asn Lys Lys Val Val Pro Leu Asp Phe Ser Met Ser Ser 
    610                 615                 620                 


Leu Ala Lys Arg Ile Lys Gln Leu His His Glu Ala Gln Gln Ser Glu 
625                 630                 635                 640 


Gly Glu Gln Asn Tyr Arg Lys Phe Arg Ala Lys Ile Cys Pro Gly Glu 
                645                 650                 655     


Asn Gln Ala Ala Glu Asp Glu Leu Arg Lys Glu Ile Ser Lys Thr Met 
            660                 665                 670         


Phe Ala Glu Met Glu Ile Ile Gly Gln Phe Asn Leu Gly Phe Ile Ile 
        675                 680                 685             


Thr Lys Leu Asn Glu Asp Ile Phe Ile Val Asp Gln His Ala Thr Asp 
    690                 695                 700                 


Glu Lys Tyr Asn Phe Glu Met Leu Gln Gln His Thr Val Leu Gln Gly 
705                 710                 715                 720 


Gln Arg Leu Ile Ala Pro Gln Thr Leu Asn Leu Thr Ala Val Asn Glu 
                725                 730                 735     


Ala Val Leu Ile Glu Asn Leu Glu Ile Phe Arg Lys Asn Gly Phe Asp 
            740                 745                 750         


Phe Val Ile Asp Glu Asn Ala Pro Val Thr Glu Arg Ala Lys Leu Ile 
        755                 760                 765             


Ser Leu Pro Thr Ser Lys Asn Trp Thr Phe Gly Pro Gln Asp Val Asp 
    770                 775                 780                 


Glu Leu Ile Phe Met Leu Ser Asp Ser Pro Gly Val Met Cys Arg Pro 
785                 790                 795                 800 


Ser Arg Val Lys Gln Met Phe Ala Ser Arg Ala Cys Arg Lys Ser Val 
                805                 810                 815     


Met Ile Gly Thr Ala Leu Asn Thr Ser Glu Met Lys Lys Leu Ile Thr 
            820                 825                 830         


His Met Gly Glu Met Asp His Pro Trp Asn Cys Pro His Gly Arg Pro 
        835                 840                 845             


Thr Met Arg His Ile Ala Asn Leu Gly Val Ile Ser Gln Asn 
    850                 855                 860         


<210>  10
<211>  740
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Lys Leu Gly Val Glu Pro Glu Glu Glu Gly Gly Gly Asp Asp 
1               5                   10                  15      


Asp Glu Glu Asp Ala Glu Ala Trp Ala Met Glu Leu Ala Asp Val Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Gln Gly Val His Asp Gln Val Leu Pro Thr Pro 
        35                  40                  45              


Asn Ala Ser Ser Arg Val Ile Val His Val Asp Leu Asp Cys Phe Tyr 
    50                  55                  60                  


Ala Gln Val Glu Met Ile Ser Asn Pro Glu Leu Lys Asp Lys Pro Leu 
65                  70                  75                  80  


Gly Val Gln Gln Lys Tyr Leu Val Val Thr Cys Asn Tyr Glu Ala Arg 
                85                  90                  95      


Lys Leu Gly Val Lys Lys Leu Met Asn Val Arg Asp Ala Lys Glu Lys 
            100                 105                 110         


Cys Pro Gln Leu Val Leu Val Asn Gly Glu Asp Leu Thr Arg Tyr Arg 
        115                 120                 125             


Glu Met Ser Tyr Lys Val Thr Glu Leu Leu Glu Glu Phe Ser Pro Val 
    130                 135                 140                 


Val Glu Arg Leu Gly Phe Asp Glu Asn Phe Val Asp Leu Thr Glu Met 
145                 150                 155                 160 


Val Glu Lys Arg Leu Gln Gln Leu Gln Ser Asp Glu Leu Ser Ala Val 
                165                 170                 175     


Thr Val Ser Gly His Val Tyr Asn Asn Gln Ser Ile Asn Leu Leu Asp 
            180                 185                 190         


Val Leu His Ile Arg Leu Leu Val Gly Ser Gln Ile Ala Ala Glu Met 
        195                 200                 205             


Arg Glu Ala Met Tyr Asn Gln Leu Gly Leu Thr Gly Cys Ala Gly Val 
    210                 215                 220                 


Ala Ser Asn Lys Leu Leu Ala Lys Leu Val Ser Gly Val Phe Lys Pro 
225                 230                 235                 240 


Asn Gln Gln Thr Val Leu Leu Pro Glu Ser Cys Gln His Leu Ile His 
                245                 250                 255     


Ser Leu Asn His Ile Lys Glu Ile Pro Gly Ile Gly Tyr Lys Thr Ala 
            260                 265                 270         


Lys Cys Leu Glu Ala Leu Gly Ile Asn Ser Val Arg Asp Leu Gln Thr 
        275                 280                 285             


Phe Ser Pro Lys Ile Leu Glu Lys Glu Leu Gly Ile Ser Val Ala Gln 
    290                 295                 300                 


Arg Ile Gln Lys Leu Ser Phe Gly Glu Asp Asn Ser Pro Val Ile Leu 
305                 310                 315                 320 


Ser Gly Pro Pro Gln Ser Phe Ser Glu Glu Asp Ser Phe Lys Lys Cys 
                325                 330                 335     


Ser Ser Glu Val Glu Ala Lys Asn Lys Ile Glu Glu Leu Leu Ala Ser 
            340                 345                 350         


Leu Leu Asn Arg Val Cys Gln Asp Gly Arg Lys Pro His Thr Val Arg 
        355                 360                 365             


Leu Ile Ile Arg Arg Tyr Ser Ser Glu Lys His Tyr Gly Arg Glu Ser 
    370                 375                 380                 


Arg Gln Cys Pro Ile Pro Ser His Val Ile Gln Lys Leu Gly Thr Gly 
385                 390                 395                 400 


Asn Tyr Asp Val Met Thr Pro Met Val Asp Ile Leu Met Lys Leu Phe 
                405                 410                 415     


Arg Asn Met Val Asn Val Lys Met Pro Phe His Leu Thr Leu Leu Ser 
            420                 425                 430         


Val Cys Phe Cys Asn Leu Lys Ala Leu Asn Thr Ala Lys Lys Gly Leu 
        435                 440                 445             


Ile Asp Tyr Tyr Leu Met Pro Ser Leu Ser Thr Thr Ser Arg Ser Gly 
    450                 455                 460                 


Lys His Ser Phe Lys Met Lys Asp Thr His Met Glu Asp Phe Pro Lys 
465                 470                 475                 480 


Asp Lys Glu Thr Asn Arg Asp Phe Leu Pro Ser Gly Arg Ile Glu Ser 
                485                 490                 495     


Thr Arg Thr Arg Glu Ser Pro Leu Asp Thr Thr Asn Phe Ser Lys Glu 
            500                 505                 510         


Lys Asp Ile Asn Glu Phe Pro Leu Cys Ser Leu Pro Glu Gly Val Asp 
        515                 520                 525             


Gln Glu Val Phe Lys Gln Leu Pro Val Asp Ile Gln Glu Glu Ile Leu 
    530                 535                 540                 


Ser Gly Lys Ser Arg Glu Lys Phe Gln Gly Lys Gly Ser Val Ser Cys 
545                 550                 555                 560 


Pro Leu His Ala Ser Arg Gly Val Leu Ser Phe Phe Ser Lys Lys Gln 
                565                 570                 575     


Met Gln Asp Ile Pro Ile Asn Pro Arg Asp His Leu Ser Ser Ser Lys 
            580                 585                 590         


Gln Val Ser Ser Val Ser Pro Cys Glu Pro Gly Thr Ser Gly Phe Asn 
        595                 600                 605             


Ser Ser Ser Ser Ser Tyr Met Ser Ser Gln Lys Asp Tyr Ser Tyr Tyr 
    610                 615                 620                 


Leu Asp Asn Arg Leu Lys Asp Glu Arg Ile Ser Gln Gly Pro Lys Glu 
625                 630                 635                 640 


Pro Gln Gly Phe His Phe Thr Asn Ser Asn Pro Ala Val Ser Ala Phe 
                645                 650                 655     


His Ser Phe Pro Asn Leu Gln Ser Glu Gln Leu Phe Ser Arg Asn His 
            660                 665                 670         


Thr Thr Asp Ser His Lys Gln Thr Val Ala Thr Asp Ser His Glu Gly 
        675                 680                 685             


Leu Thr Glu Asn Arg Glu Pro Asp Ser Val Asp Glu Lys Ile Thr Phe 
    690                 695                 700                 


Pro Ser Asp Ile Asp Pro Gln Val Phe Tyr Glu Leu Pro Glu Ala Val 
705                 710                 715                 720 


Gln Lys Glu Leu Leu Ala Glu Trp Lys Arg Ala Gly Ser Asp Phe His 
                725                 730                 735     


Ile Gly His Lys 
            740 


<210>  11
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Ser Thr Ala Asp Ala Leu Asp Asp Glu Asn Thr Phe Lys Ile Leu 
1               5                   10                  15      


Val Ala Thr Asp Ile His Leu Gly Phe Met Glu Lys Asp Ala Val Arg 
            20                  25                  30          


Gly Asn Asp Thr Phe Val Thr Leu Asp Glu Ile Leu Arg Leu Ala Gln 
        35                  40                  45              


Glu Asn Glu Val Asp Phe Ile Leu Leu Gly Gly Asp Leu Phe His Glu 
    50                  55                  60                  


Asn Lys Pro Ser Arg Lys Thr Leu His Thr Cys Leu Glu Leu Leu Arg 
65                  70                  75                  80  


Lys Tyr Cys Met Gly Asp Arg Pro Val Gln Phe Glu Ile Leu Ser Asp 
                85                  90                  95      


Gln Ser Val Asn Phe Gly Phe Ser Lys Phe Pro Trp Val Asn Tyr Gln 
            100                 105                 110         


Asp Gly Asn Leu Asn Ile Ser Ile Pro Val Phe Ser Ile His Gly Asn 
        115                 120                 125             


His Asp Asp Pro Thr Gly Ala Asp Ala Leu Cys Ala Leu Asp Ile Leu 
    130                 135                 140                 


Ser Cys Ala Gly Phe Val Asn His Phe Gly Arg Ser Met Ser Val Glu 
145                 150                 155                 160 


Lys Ile Asp Ile Ser Pro Val Leu Leu Gln Lys Gly Ser Thr Lys Ile 
                165                 170                 175     


Ala Leu Tyr Gly Leu Gly Ser Ile Pro Asp Glu Arg Leu Tyr Arg Met 
            180                 185                 190         


Phe Val Asn Lys Lys Val Thr Met Leu Arg Pro Lys Glu Asp Glu Asn 
        195                 200                 205             


Ser Trp Phe Asn Leu Phe Val Ile His Gln Asn Arg Ser Lys His Gly 
    210                 215                 220                 


Ser Thr Asn Phe Ile Pro Glu Gln Phe Leu Asp Asp Phe Ile Asp Leu 
225                 230                 235                 240 


Val Ile Trp Gly His Glu His Glu Cys Lys Ile Ala Pro Thr Lys Asn 
                245                 250                 255     


Glu Gln Gln Leu Phe Tyr Ile Ser Gln Pro Gly Ser Ser Val Val Thr 
            260                 265                 270         


Ser Leu Ser Pro Gly Glu Ala Val Lys Lys His Val Gly Leu Leu Arg 
        275                 280                 285             


Ile Lys Gly Arg Lys Met Asn Met His Lys Ile Pro Leu His Thr Val 
    290                 295                 300                 


Arg Gln Phe Phe Met Glu Asp Ile Val Leu Ala Asn His Pro Asp Ile 
305                 310                 315                 320 


Phe Asn Pro Asp Asn Pro Lys Val Thr Gln Ala Ile Gln Ser Phe Cys 
                325                 330                 335     


Leu Glu Lys Ile Glu Glu Met Leu Glu Asn Ala Glu Arg Glu Arg Leu 
            340                 345                 350         


Gly Asn Ser His Gln Pro Glu Lys Pro Leu Val Arg Leu Arg Val Asp 
        355                 360                 365             


Tyr Ser Gly Gly Phe Glu Pro Phe Ser Val Leu Arg Phe Ser Gln Lys 
    370                 375                 380                 


Phe Val Asp Arg Val Ala Asn Pro Lys Asp Ile Ile His Phe Phe Arg 
385                 390                 395                 400 


His Arg Glu Gln Lys Glu Lys Thr Gly Glu Glu Ile Asn Phe Gly Lys 
                405                 410                 415     


Leu Ile Thr Lys Pro Ser Glu Gly Thr Thr Leu Arg Val Glu Asp Leu 
            420                 425                 430         


Val Lys Gln Tyr Phe Gln Thr Ala Glu Lys Asn Val Gln Leu Ser Leu 
        435                 440                 445             


Leu Thr Glu Arg Gly Met Gly Glu Ala Val Gln Glu Phe Val Asp Lys 
    450                 455                 460                 


Glu Glu Lys Asp Ala Ile Glu Glu Leu Val Lys Tyr Gln Leu Glu Lys 
465                 470                 475                 480 


Thr Gln Arg Phe Leu Lys Glu Arg His Ile Asp Ala Leu Glu Asp Lys 
                485                 490                 495     


Ile Asp Glu Glu Val Arg Arg Phe Arg Glu Thr Arg Gln Lys Asn Thr 
            500                 505                 510         


Asn Glu Glu Asp Asp Glu Val Arg Glu Ala Met Thr Arg Ala Arg Ala 
        515                 520                 525             


Leu Arg Ser Gln Ser Glu Glu Ser Ala Ser Ala Phe Ser Ala Asp Asp 
    530                 535                 540                 


Leu Met Ser Ile Asp Leu Ala Glu Gln Met Ala Asn Asp Ser Asp Asp 
545                 550                 555                 560 


Ser Ile Ser Ala Ala Thr Asn Lys Gly Arg Gly Arg Gly Arg Gly Arg 
                565                 570                 575     


Arg Gly Gly Arg Gly Gln Asn Ser Ala Ser Arg Gly Gly Ser Gln Arg 
            580                 585                 590         


Gly Arg Ala Asp Thr Gly Leu Glu Thr Ser Thr Arg Ser Arg Asn Ser 
        595                 600                 605             


Lys Thr Ala Val Ser Ala Ser Arg Asn Met Ser Ile Ile Asp Ala Phe 
    610                 615                 620                 


Lys Ser Thr Arg Gln Gln Pro Ser Arg Asn Val Thr Thr Lys Asn Tyr 
625                 630                 635                 640 


Ser Glu Val Ile Glu Val Asp Glu Ser Asp Val Glu Glu Asp Ile Phe 
                645                 650                 655     


Pro Thr Thr Ser Lys Thr Asp Gln Arg Trp Ser Ser Thr Ser Ser Ser 
            660                 665                 670         


Lys Ile Met Ser Gln Ser Gln Val Ser Lys Gly Val Asp Phe Glu Ser 
        675                 680                 685             


Ser Glu Asp Asp Asp Asp Asp Pro Phe Met Asn Thr Ser Ser Leu Arg 
    690                 695                 700                 


Arg Asn Arg Arg 
705             


<210>  12
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Gly Thr Glu Glu Ala Ile Leu Gly Gly Arg Asp Ser His Pro 
1               5                   10                  15      


Ala Ala Gly Gly Gly Ser Val Leu Cys Phe Gly Gln Cys Gln Tyr Thr 
            20                  25                  30          


Ala Glu Glu Tyr Gln Ala Ile Gln Lys Ala Leu Arg Gln Arg Leu Gly 
        35                  40                  45              


Pro Glu Tyr Ile Ser Ser Arg Met Ala Gly Gly Gly Gln Lys Val Cys 
    50                  55                  60                  


Tyr Ile Glu Gly His Arg Val Ile Asn Leu Ala Asn Glu Met Phe Gly 
65                  70                  75                  80  


Tyr Asn Gly Trp Ala His Ser Ile Thr Gln Gln Asn Val Asp Phe Val 
                85                  90                  95      


Asp Leu Asn Asn Gly Lys Phe Tyr Val Gly Val Cys Ala Phe Val Arg 
            100                 105                 110         


Val Gln Leu Lys Asp Gly Ser Tyr His Glu Asp Val Gly Tyr Gly Val 
        115                 120                 125             


Ser Glu Gly Leu Lys Ser Lys Ala Leu Ser Leu Glu Lys Ala Arg Lys 
    130                 135                 140                 


Glu Ala Val Thr Asp Gly Leu Lys Arg Ala Leu Arg Ser Phe Gly Asn 
145                 150                 155                 160 


Ala Leu Gly Asn Cys Ile Leu Asp Lys Asp Tyr Leu Arg Ser Leu Asn 
                165                 170                 175     


Lys Leu Pro Arg Gln Leu Pro Leu Glu Val Asp Leu Thr Lys Ala Lys 
            180                 185                 190         


Arg Gln Asp Leu Glu Pro Ser Val Glu Glu Ala Arg Tyr Asn Ser Cys 
        195                 200                 205             


Arg Pro Asn Met Ala Leu Gly His Pro Gln Leu Gln Gln Val Thr Ser 
    210                 215                 220                 


Pro Ser Arg Pro Ser His Ala Val Ile Pro Ala Asp Gln Asp Cys Ser 
225                 230                 235                 240 


Ser Arg Ser Leu Ser Ser Ser Ala Val Glu Ser Glu Ala Thr His Gln 
                245                 250                 255     


Arg Lys Leu Arg Gln Lys Gln Leu Gln Gln Gln Phe Arg Glu Arg Met 
            260                 265                 270         


Glu Lys Gln Gln Val Arg Val Ser Thr Pro Ser Ala Glu Lys Ser Glu 
        275                 280                 285             


Ala Ala Pro Pro Ala Pro Pro Val Thr His Ser Thr Pro Val Thr Val 
    290                 295                 300                 


Ser Glu Pro Leu Leu Glu Lys Asp Phe Leu Ala Gly Val Thr Gln Glu 
305                 310                 315                 320 


Leu Ile Lys Thr Leu Glu Asp Asn Ser Glu Lys Trp Ala Val Thr Pro 
                325                 330                 335     


Asp Ala Gly Asp Gly Val Val Lys Pro Ser Ser Arg Ala Asp Pro Ala 
            340                 345                 350         


Gln Thr Ser Asp Thr Leu Ala Leu Asn Asn Gln Met Val Thr Gln Asn 
        355                 360                 365             


Arg Thr Pro His Ser Val Cys His Gln Lys Pro Gln Ala Lys Ser Gly 
    370                 375                 380                 


Ser Trp Asp Leu Gln Thr Tyr Ser Ala Asp Gln Arg Thr Thr Gly Asn 
385                 390                 395                 400 


Trp Glu Ser His Arg Lys Ser Gln Asp Met Lys Lys Arg Lys Tyr Asp 
                405                 410                 415     


Pro Ser 
        


<210>  13
<211>  1300
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Pro Lys Ile Val Leu Asn Gly Val Thr Val Asp Phe Pro Phe Gln 
1               5                   10                  15      


Pro Tyr Lys Cys Gln Gln Glu Tyr Met Thr Lys Val Leu Glu Cys Leu 
            20                  25                  30          


Gln Gln Lys Val Asn Gly Ile Leu Glu Ser Pro Thr Gly Thr Gly Lys 
        35                  40                  45              


Thr Leu Cys Leu Leu Cys Thr Thr Leu Ala Trp Arg Glu His Leu Arg 
    50                  55                  60                  


Asp Gly Ile Ser Ala Arg Lys Ile Ala Glu Arg Ala Gln Gly Glu Leu 
65                  70                  75                  80  


Phe Pro Asp Arg Ala Leu Ser Ser Trp Gly Asn Ala Ala Ala Ala Ala 
                85                  90                  95      


Gly Asp Pro Ile Ala Cys Tyr Thr Asp Ile Pro Lys Ile Ile Tyr Ala 
            100                 105                 110         


Ser Arg Thr His Ser Gln Leu Thr Gln Val Ile Asn Glu Leu Arg Asn 
        115                 120                 125             


Thr Ser Tyr Arg Pro Lys Val Cys Val Leu Gly Ser Arg Glu Gln Leu 
    130                 135                 140                 


Cys Ile His Pro Glu Val Lys Lys Gln Glu Ser Asn His Leu Gln Ile 
145                 150                 155                 160 


His Leu Cys Arg Lys Lys Val Ala Ser Arg Ser Cys His Phe Tyr Asn 
                165                 170                 175     


Asn Val Glu Glu Lys Ser Leu Glu Gln Glu Leu Ala Ser Pro Ile Leu 
            180                 185                 190         


Asp Ile Glu Asp Leu Val Lys Ser Gly Ser Lys His Arg Val Cys Pro 
        195                 200                 205             


Tyr Tyr Leu Ser Arg Asn Leu Lys Gln Gln Ala Asp Ile Ile Phe Met 
    210                 215                 220                 


Pro Tyr Asn Tyr Leu Leu Asp Ala Lys Ser Arg Arg Ala His Asn Ile 
225                 230                 235                 240 


Asp Leu Lys Gly Thr Val Val Ile Phe Asp Glu Ala His Asn Val Glu 
                245                 250                 255     


Lys Met Cys Glu Glu Ser Ala Ser Phe Asp Leu Thr Pro His Asp Leu 
            260                 265                 270         


Ala Ser Gly Leu Asp Val Ile Asp Gln Val Leu Glu Glu Gln Thr Lys 
        275                 280                 285             


Ala Ala Gln Gln Gly Glu Pro His Pro Glu Phe Ser Ala Asp Ser Pro 
    290                 295                 300                 


Ser Pro Gly Leu Asn Met Glu Leu Glu Asp Ile Ala Lys Leu Lys Met 
305                 310                 315                 320 


Ile Leu Leu Arg Leu Glu Gly Ala Ile Asp Ala Val Glu Leu Pro Gly 
                325                 330                 335     


Asp Asp Ser Gly Val Thr Lys Pro Gly Ser Tyr Ile Phe Glu Leu Phe 
            340                 345                 350         


Ala Glu Ala Gln Ile Thr Phe Gln Thr Lys Gly Cys Ile Leu Asp Ser 
        355                 360                 365             


Leu Asp Gln Ile Ile Gln His Leu Ala Gly Arg Ala Gly Val Phe Thr 
    370                 375                 380                 


Asn Thr Ala Gly Leu Gln Lys Leu Ala Asp Ile Ile Gln Ile Val Phe 
385                 390                 395                 400 


Ser Val Asp Pro Ser Glu Gly Ser Pro Gly Ser Pro Ala Gly Leu Gly 
                405                 410                 415     


Ala Leu Gln Ser Tyr Lys Val His Ile His Pro Asp Ala Gly His Arg 
            420                 425                 430         


Arg Thr Ala Gln Arg Ser Asp Ala Trp Ser Thr Thr Ala Ala Arg Lys 
        435                 440                 445             


Arg Gly Lys Val Leu Ser Tyr Trp Cys Phe Ser Pro Gly His Ser Met 
    450                 455                 460                 


His Glu Leu Val Arg Gln Gly Val Arg Ser Leu Ile Leu Thr Ser Gly 
465                 470                 475                 480 


Thr Leu Ala Pro Val Ser Ser Phe Ala Leu Glu Met Gln Ile Pro Phe 
                485                 490                 495     


Pro Val Cys Leu Glu Asn Pro His Ile Ile Asp Lys His Gln Ile Trp 
            500                 505                 510         


Val Gly Val Val Pro Arg Gly Pro Asp Gly Ala Gln Leu Ser Ser Ala 
        515                 520                 525             


Phe Asp Arg Arg Phe Ser Glu Glu Cys Leu Ser Ser Leu Gly Lys Ala 
    530                 535                 540                 


Leu Gly Asn Ile Ala Arg Val Val Pro Tyr Gly Leu Leu Ile Phe Phe 
545                 550                 555                 560 


Pro Ser Tyr Pro Val Met Glu Lys Ser Leu Glu Phe Trp Arg Ala Arg 
                565                 570                 575     


Asp Leu Ala Arg Lys Met Glu Ala Leu Lys Pro Leu Phe Val Glu Pro 
            580                 585                 590         


Arg Ser Lys Gly Ser Phe Ser Glu Thr Ile Ser Ala Tyr Tyr Ala Arg 
        595                 600                 605             


Val Ala Ala Pro Gly Ser Thr Gly Ala Thr Phe Leu Ala Val Cys Arg 
    610                 615                 620                 


Gly Lys Ala Ser Glu Gly Leu Asp Phe Ser Asp Thr Asn Gly Arg Gly 
625                 630                 635                 640 


Val Ile Val Thr Gly Leu Pro Tyr Pro Pro Arg Met Asp Pro Arg Val 
                645                 650                 655     


Val Leu Lys Met Gln Phe Leu Asp Glu Met Lys Gly Gln Gly Gly Ala 
            660                 665                 670         


Gly Gly Gln Phe Leu Ser Gly Gln Glu Trp Tyr Arg Gln Gln Ala Ser 
        675                 680                 685             


Arg Ala Val Asn Gln Ala Ile Gly Arg Val Ile Arg His Arg Gln Asp 
    690                 695                 700                 


Tyr Gly Ala Val Phe Leu Cys Asp His Arg Phe Ala Phe Ala Asp Ala 
705                 710                 715                 720 


Arg Ala Gln Leu Pro Ser Trp Val Arg Pro His Val Arg Val Tyr Asp 
                725                 730                 735     


Asn Phe Gly His Val Ile Arg Asp Val Ala Gln Phe Phe Arg Val Ala 
            740                 745                 750         


Glu Arg Thr Met Pro Ala Pro Ala Pro Arg Ala Thr Ala Pro Ser Val 
        755                 760                 765             


Arg Gly Glu Asp Ala Val Ser Glu Ala Lys Ser Pro Gly Pro Phe Phe 
    770                 775                 780                 


Ser Thr Arg Lys Ala Lys Ser Leu Asp Leu His Val Pro Ser Leu Lys 
785                 790                 795                 800 


Gln Arg Ser Ser Gly Ser Pro Ala Ala Gly Asp Pro Glu Ser Ser Leu 
                805                 810                 815     


Cys Val Glu Tyr Glu Gln Glu Pro Val Pro Ala Arg Gln Arg Pro Arg 
            820                 825                 830         


Gly Leu Leu Ala Ala Leu Glu His Ser Glu Gln Arg Ala Gly Ser Pro 
        835                 840                 845             


Gly Glu Glu Gln Ala His Ser Cys Ser Thr Leu Ser Leu Leu Ser Glu 
    850                 855                 860                 


Lys Arg Pro Ala Glu Glu Pro Arg Gly Gly Arg Lys Lys Ile Arg Leu 
865                 870                 875                 880 


Val Ser His Pro Glu Glu Pro Val Ala Gly Ala Gln Thr Asp Arg Ala 
                885                 890                 895     


Lys Leu Phe Met Val Ala Val Lys Gln Glu Leu Ser Gln Ala Asn Phe 
            900                 905                 910         


Ala Thr Phe Thr Gln Ala Leu Gln Asp Tyr Lys Gly Ser Asp Asp Phe 
        915                 920                 925             


Ala Ala Leu Ala Ala Cys Leu Gly Pro Leu Phe Ala Glu Asp Pro Lys 
    930                 935                 940                 


Lys His Asn Leu Leu Gln Gly Phe Tyr Gln Phe Val Arg Pro His His 
945                 950                 955                 960 


Lys Gln Gln Phe Glu Glu Val Cys Ile Gln Leu Thr Gly Arg Gly Cys 
                965                 970                 975     


Gly Tyr Arg Pro Glu His Ser Ile Pro Arg Arg Gln Arg Ala Gln Pro 
            980                 985                 990         


Val Leu Asp Pro Thr Gly Arg Thr  Ala Pro Asp Pro Lys  Leu Thr Val 
        995                 1000                 1005             


Ser Thr  Ala Ala Ala Gln Gln  Leu Asp Pro Gln Glu  His Leu Asn 
    1010                 1015                 1020             


Gln Gly  Arg Pro His Leu Ser  Pro Arg Pro Pro Pro  Thr Gly Asp 
    1025                 1030                 1035             


Pro Gly  Ser Gln Pro Gln Trp  Gly Ser Gly Val Pro  Arg Ala Gly 
    1040                 1045                 1050             


Lys Gln  Gly Gln His Ala Val  Ser Ala Tyr Leu Ala  Asp Ala Arg 
    1055                 1060                 1065             


Arg Ala  Leu Gly Ser Ala Gly  Cys Ser Gln Leu Leu  Ala Ala Leu 
    1070                 1075                 1080             


Thr Ala  Tyr Lys Gln Asp Asp  Asp Leu Asp Lys Val  Leu Ala Val 
    1085                 1090                 1095             


Leu Ala  Ala Leu Thr Thr Ala  Lys Pro Glu Asp Phe  Pro Leu Leu 
    1100                 1105                 1110             


His Arg  Phe Ser Met Phe Val  Arg Pro His His Lys  Gln Arg Phe 
    1115                 1120                 1125             


Ser Gln  Thr Cys Thr Asp Leu  Thr Gly Arg Pro Tyr  Pro Gly Met 
    1130                 1135                 1140             


Glu Pro  Pro Gly Pro Gln Glu  Glu Arg Leu Ala Val  Pro Pro Val 
    1145                 1150                 1155             


Leu Thr  His Arg Ala Pro Gln  Pro Gly Pro Ser Arg  Ser Glu Lys 
    1160                 1165                 1170             


Thr Gly  Lys Thr Gln Ser Lys  Ile Ser Ser Phe Leu  Arg Gln Arg 
    1175                 1180                 1185             


Pro Ala  Gly Thr Val Gly Ala  Gly Gly Glu Asp Ala  Gly Pro Ser 
    1190                 1195                 1200             


Gln Ser  Ser Gly Pro Pro His  Gly Pro Ala Ala Ser  Glu Trp Gly 
    1205                 1210                 1215             


Glu Pro  His Gly Arg Asp Ile  Ala Gly Gln Gln Ala  Thr Gly Ala 
    1220                 1225                 1230             


Pro Gly  Gly Pro Leu Ser Ala  Gly Cys Val Cys Gln  Gly Cys Gly 
    1235                 1240                 1245             


Ala Glu  Asp Val Val Pro Phe  Gln Cys Pro Ala Cys  Asp Phe Gln 
    1250                 1255                 1260             


Arg Cys  Gln Ala Cys Trp Gln  Arg His Leu Gln Ala  Ser Arg Met 
    1265                 1270                 1275             


Cys Pro  Ala Cys His Thr Ala  Ser Arg Lys Gln Ser  Val Met Gln 
    1280                 1285                 1290             


Val Phe  Trp Pro Glu Pro Gln  
    1295                 1300 


<210>  14
<211>  3230
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gln Ser Ser Pro Ser Pro Ala His Pro Gln Leu Pro Val Leu Gln 
1               5                   10                  15      


Thr Gln Met Val Ser Asp Gly Met Thr Gly Ser Asn Pro Val Ser Pro 
            20                  25                  30          


Ala Ser Ser Ser Ser Pro Ala Ser Ser Gly Ala Gly Gly Ile Ser Pro 
        35                  40                  45              


Gln His Ile Ala Gln Asp Ser Ser Leu Asp Gly Pro Pro Gly Pro Pro 
    50                  55                  60                  


Asp Gly Ala Thr Val Pro Leu Glu Gly Phe Ser Leu Ser Gln Ala Ala 
65                  70                  75                  80  


Asp Leu Ala Asn Lys Gly Pro Lys Trp Glu Lys Ser His Ala Glu Ile 
                85                  90                  95      


Ala Glu Gln Ala Lys His Glu Ala Glu Ile Glu Thr Arg Ile Ala Glu 
            100                 105                 110         


Leu Arg Lys Glu Gly Phe Trp Ser Leu Lys Arg Leu Pro Lys Val Pro 
        115                 120                 125             


Glu Pro Pro Arg Pro Lys Gly His Trp Asp Tyr Leu Cys Glu Glu Met 
    130                 135                 140                 


Gln Trp Leu Ser Ala Asp Phe Ala Gln Glu Arg Arg Trp Lys Arg Gly 
145                 150                 155                 160 


Val Ala Arg Lys Val Val Arg Met Val Ile Arg His His Glu Glu Gln 
                165                 170                 175     


Arg Gln Lys Glu Glu Arg Ala Arg Arg Glu Glu Gln Ala Lys Leu Arg 
            180                 185                 190         


Arg Ile Ala Ser Thr Met Ala Lys Asp Val Arg Gln Phe Trp Ser Asn 
        195                 200                 205             


Val Glu Lys Val Val Gln Phe Lys Gln Gln Ser Arg Leu Glu Glu Lys 
    210                 215                 220                 


Arg Lys Lys Ala Leu Asp Leu His Leu Asp Phe Ile Val Gly Gln Thr 
225                 230                 235                 240 


Glu Lys Tyr Ser Asp Leu Leu Ser Gln Ser Leu Asn Gln Pro Leu Thr 
                245                 250                 255     


Ser Ser Lys Ala Gly Ser Ser Pro Cys Leu Gly Ser Ser Ser Ala Ala 
            260                 265                 270         


Ser Ser Pro Pro Pro Pro Ala Ser Arg Leu Asp Asp Glu Asp Gly Asp 
        275                 280                 285             


Phe Gln Pro Gln Glu Asp Glu Glu Glu Asp Asp Glu Glu Thr Ile Glu 
    290                 295                 300                 


Val Glu Glu Gln Gln Glu Gly Asn Asp Ala Glu Ala Gln Arg Arg Glu 
305                 310                 315                 320 


Ile Glu Leu Leu Arg Arg Glu Gly Glu Leu Pro Leu Glu Glu Leu Leu 
                325                 330                 335     


Arg Ser Leu Pro Pro Gln Leu Leu Glu Gly Pro Ser Ser Pro Ser Gln 
            340                 345                 350         


Thr Pro Ser Ser His Asp Ser Asp Thr Arg Asp Gly Pro Glu Glu Gly 
        355                 360                 365             


Ala Glu Glu Glu Pro Pro Gln Val Leu Glu Ile Lys Pro Pro Pro Ser 
    370                 375                 380                 


Ala Val Thr Gln Arg Asn Lys Gln Pro Trp His Pro Asp Glu Asp Asp 
385                 390                 395                 400 


Glu Glu Phe Thr Ala Asn Glu Glu Glu Ala Glu Asp Glu Glu Asp Thr 
                405                 410                 415     


Ile Ala Ala Glu Glu Gln Leu Glu Gly Glu Val Asp His Ala Met Glu 
            420                 425                 430         


Leu Ser Glu Leu Ala Arg Glu Gly Glu Leu Ser Met Glu Glu Leu Leu 
        435                 440                 445             


Gln Gln Tyr Ala Gly Ala Tyr Ala Pro Gly Ser Gly Ser Ser Glu Asp 
    450                 455                 460                 


Glu Asp Glu Asp Glu Val Asp Ala Asn Ser Ser Asp Cys Glu Pro Glu 
465                 470                 475                 480 


Gly Pro Val Glu Ala Glu Glu Pro Pro Gln Glu Asp Ser Ser Ser Gln 
                485                 490                 495     


Ser Asp Ser Val Glu Asp Arg Ser Glu Asp Glu Glu Asp Glu His Ser 
            500                 505                 510         


Glu Glu Glu Glu Thr Ser Gly Ser Ser Ala Ser Glu Glu Ser Glu Ser 
        515                 520                 525             


Glu Glu Ser Glu Asp Ala Gln Ser Gln Ser Gln Ala Asp Glu Glu Glu 
    530                 535                 540                 


Glu Asp Asp Asp Phe Gly Val Glu Tyr Leu Leu Ala Arg Asp Glu Glu 
545                 550                 555                 560 


Gln Ser Glu Ala Asp Ala Gly Ser Gly Pro Pro Thr Pro Gly Pro Thr 
                565                 570                 575     


Thr Leu Gly Pro Lys Lys Glu Ile Thr Asp Ile Ala Ala Ala Ala Glu 
            580                 585                 590         


Ser Leu Gln Pro Lys Gly Tyr Thr Leu Ala Thr Thr Gln Val Lys Thr 
        595                 600                 605             


Pro Ile Pro Leu Leu Leu Arg Gly Gln Leu Arg Glu Tyr Gln His Ile 
    610                 615                 620                 


Gly Leu Asp Trp Leu Val Thr Met Tyr Glu Lys Lys Leu Asn Gly Ile 
625                 630                 635                 640 


Leu Ala Asp Glu Met Gly Leu Gly Lys Thr Ile Gln Thr Ile Ser Leu 
                645                 650                 655     


Leu Ala His Leu Ala Cys Glu Lys Gly Asn Trp Gly Pro His Leu Ile 
            660                 665                 670         


Ile Val Pro Thr Ser Val Met Leu Asn Trp Glu Met Glu Leu Lys Arg 
        675                 680                 685             


Trp Cys Pro Ser Phe Lys Ile Leu Thr Tyr Tyr Gly Ala Gln Lys Glu 
    690                 695                 700                 


Arg Lys Leu Lys Arg Gln Gly Trp Thr Lys Pro Asn Ala Phe His Val 
705                 710                 715                 720 


Cys Ile Thr Ser Tyr Lys Leu Val Leu Gln Asp His Gln Ala Phe Arg 
                725                 730                 735     


Arg Lys Asn Trp Arg Tyr Leu Ile Leu Asp Glu Ala Gln Asn Ile Lys 
            740                 745                 750         


Asn Phe Lys Ser Gln Arg Trp Gln Ser Leu Leu Asn Phe Asn Ser Gln 
        755                 760                 765             


Arg Arg Leu Leu Leu Thr Gly Thr Pro Leu Gln Asn Ser Leu Met Glu 
    770                 775                 780                 


Leu Trp Ser Leu Met His Phe Leu Met Pro His Val Phe Gln Ser His 
785                 790                 795                 800 


Arg Glu Phe Lys Glu Trp Phe Ser Asn Pro Leu Thr Gly Met Ile Glu 
                805                 810                 815     


Gly Ser Gln Glu Tyr Asn Glu Gly Leu Val Lys Arg Leu His Lys Val 
            820                 825                 830         


Leu Arg Pro Phe Leu Leu Arg Arg Val Lys Val Asp Val Glu Lys Gln 
        835                 840                 845             


Met Pro Lys Lys Tyr Glu His Val Ile Arg Cys Arg Leu Ser Lys Arg 
    850                 855                 860                 


Gln Arg Cys Leu Tyr Asp Asp Phe Met Ala Gln Thr Thr Thr Lys Glu 
865                 870                 875                 880 


Thr Leu Ala Thr Gly His Phe Met Ser Val Ile Asn Ile Leu Met Gln 
                885                 890                 895     


Leu Arg Lys Val Cys Asn His Pro Asn Leu Phe Asp Pro Arg Pro Val 
            900                 905                 910         


Thr Ser Pro Phe Ile Thr Pro Gly Ile Cys Phe Ser Thr Ala Ser Leu 
        915                 920                 925             


Val Leu Arg Ala Thr Asp Val His Pro Leu Gln Arg Ile Asp Met Gly 
    930                 935                 940                 


Arg Phe Asp Leu Ile Gly Leu Glu Gly Arg Val Ser Arg Tyr Glu Ala 
945                 950                 955                 960 


Asp Thr Phe Leu Pro Arg His Arg Leu Ser Arg Arg Val Leu Leu Glu 
                965                 970                 975     


Val Ala Thr Ala Pro Asp Pro Pro Pro Arg Pro Lys Pro Val Lys Met 
            980                 985                 990         


Lys Val Asn Arg Met Leu Gln Pro  Val Pro Lys Gln Glu  Gly Arg Thr 
        995                 1000                 1005             


Val Val  Val Val Asn Asn Pro  Arg Ala Pro Leu Gly  Pro Val Pro 
    1010                 1015                 1020             


Val Arg  Pro Pro Pro Gly Pro  Glu Leu Ser Ala Gln  Pro Thr Pro 
    1025                 1030                 1035             


Gly Pro  Val Pro Gln Val Leu  Pro Ala Ser Leu Met  Val Ser Ala 
    1040                 1045                 1050             


Ser Pro  Ala Gly Pro Pro Leu  Ile Pro Ala Ser Arg  Pro Pro Gly 
    1055                 1060                 1065             


Pro Val  Leu Leu Pro Pro Leu  Gln Pro Asn Ser Gly  Ser Leu Pro 
    1070                 1075                 1080             


Gln Val  Leu Pro Ser Pro Leu  Gly Val Leu Ser Gly  Thr Ser Arg 
    1085                 1090                 1095             


Pro Pro  Thr Pro Thr Leu Ser  Leu Lys Pro Thr Pro  Pro Ala Pro 
    1100                 1105                 1110             


Val Arg  Leu Ser Pro Ala Pro  Pro Pro Gly Ser Ser  Ser Leu Leu 
    1115                 1120                 1125             


Lys Pro  Leu Thr Val Pro Pro  Gly Tyr Thr Phe Pro  Pro Ala Ala 
    1130                 1135                 1140             


Ala Thr  Thr Thr Ser Thr Thr  Thr Ala Thr Ala Thr  Thr Thr Ala 
    1145                 1150                 1155             


Val Pro  Ala Pro Thr Pro Ala  Pro Gln Arg Leu Ile  Leu Ser Pro 
    1160                 1165                 1170             


Asp Met  Gln Ala Arg Leu Pro  Ser Gly Glu Val Val  Ser Ile Gly 
    1175                 1180                 1185             


Gln Leu  Ala Ser Leu Ala Gln  Arg Pro Val Ala Asn  Ala Gly Gly 
    1190                 1195                 1200             


Ser Lys  Pro Leu Thr Phe Gln  Ile Gln Gly Asn Lys  Leu Thr Leu 
    1205                 1210                 1215             


Thr Gly  Ala Gln Val Arg Gln  Leu Ala Val Gly Gln  Pro Arg Pro 
    1220                 1225                 1230             


Leu Gln  Arg Asn Val Val His  Leu Val Ser Ala Gly  Gly Gln His 
    1235                 1240                 1245             


His Leu  Ile Ser Gln Pro Ala  His Val Ala Leu Ile  Gln Ala Val 
    1250                 1255                 1260             


Ala Pro  Thr Pro Gly Pro Thr  Pro Val Ser Val Leu  Pro Ser Ser 
    1265                 1270                 1275             


Thr Pro  Ser Thr Thr Pro Ala  Pro Thr Gly Leu Ser  Leu Pro Leu 
    1280                 1285                 1290             


Ala Ala  Asn Gln Val Pro Pro  Thr Met Val Asn Asn  Thr Gly Val 
    1295                 1300                 1305             


Val Lys  Ile Val Val Arg Gln  Ala Pro Arg Asp Gly  Leu Thr Pro 
    1310                 1315                 1320             


Val Pro  Pro Leu Ala Pro Ala  Pro Arg Pro Pro Ser  Ser Gly Leu 
    1325                 1330                 1335             


Pro Ala  Val Leu Asn Pro Arg  Pro Thr Leu Thr Pro  Gly Arg Leu 
    1340                 1345                 1350             


Pro Thr  Pro Thr Leu Gly Thr  Ala Arg Ala Pro Met  Pro Thr Pro 
    1355                 1360                 1365             


Thr Leu  Val Arg Pro Leu Leu  Lys Leu Val His Ser  Pro Ser Pro 
    1370                 1375                 1380             


Glu Val  Ser Ala Ser Ala Pro  Gly Ala Ala Pro Leu  Thr Ile Ser 
    1385                 1390                 1395             


Ser Pro  Leu His Val Pro Ser  Ser Leu Pro Gly Pro  Ala Ser Ser 
    1400                 1405                 1410             


Pro Met  Pro Ile Pro Asn Ser  Ser Pro Leu Ala Ser  Pro Val Ser 
    1415                 1420                 1425             


Ser Thr  Val Ser Val Pro Leu  Ser Ser Ser Leu Pro  Ile Ser Val 
    1430                 1435                 1440             


Pro Thr  Thr Leu Pro Ala Pro  Ala Ser Ala Pro Leu  Thr Ile Pro 
    1445                 1450                 1455             


Ile Ser  Ala Pro Leu Thr Val  Ser Ala Ser Gly Pro  Ala Leu Leu 
    1460                 1465                 1470             


Thr Ser  Val Thr Pro Pro Leu  Ala Pro Val Val Pro  Ala Ala Pro 
    1475                 1480                 1485             


Gly Pro  Pro Ser Leu Ala Pro  Ser Gly Ala Ser Pro  Ser Ala Ser 
    1490                 1495                 1500             


Ala Leu  Thr Leu Gly Leu Ala  Thr Ala Pro Ser Leu  Ser Ser Ser 
    1505                 1510                 1515             


Gln Thr  Pro Gly His Pro Leu  Leu Leu Ala Pro Thr  Ser Ser His 
    1520                 1525                 1530             


Val Pro  Gly Leu Asn Ser Thr  Val Ala Pro Ala Cys  Ser Pro Val 
    1535                 1540                 1545             


Leu Val  Pro Ala Ser Ala Leu  Ala Ser Pro Phe Pro  Ser Ala Pro 
    1550                 1555                 1560             


Asn Pro  Ala Pro Ala Gln Ala  Ser Leu Leu Ala Pro  Ala Ser Ser 
    1565                 1570                 1575             


Ala Ser  Gln Ala Leu Ala Thr  Pro Leu Ala Pro Met  Ala Ala Pro 
    1580                 1585                 1590             


Gln Thr  Ala Ile Leu Ala Pro  Ser Pro Ala Pro Pro  Leu Ala Pro 
    1595                 1600                 1605             


Leu Pro  Val Leu Ala Pro Ser  Pro Gly Ala Ala Pro  Val Leu Ala 
    1610                 1615                 1620             


Ser Ser  Gln Thr Pro Val Pro  Val Met Ala Pro Ser  Ser Thr Pro 
    1625                 1630                 1635             


Gly Thr  Ser Leu Ala Ser Ala  Ser Pro Val Pro Ala  Pro Thr Pro 
    1640                 1645                 1650             


Val Leu  Ala Pro Ser Ser Thr  Gln Thr Met Leu Pro  Ala Pro Val 
    1655                 1660                 1665             


Pro Ser  Pro Leu Pro Ser Pro  Ala Ser Thr Gln Thr  Leu Ala Leu 
    1670                 1675                 1680             


Ala Pro  Ala Leu Ala Pro Thr  Leu Gly Gly Ser Ser  Pro Ser Gln 
    1685                 1690                 1695             


Thr Leu  Ser Leu Gly Thr Gly  Asn Pro Gln Gly Pro  Phe Pro Thr 
    1700                 1705                 1710             


Gln Thr  Leu Ser Leu Thr Pro  Ala Ser Ser Leu Val  Pro Thr Pro 
    1715                 1720                 1725             


Ala Gln  Thr Leu Ser Leu Ala  Pro Gly Pro Pro Leu  Gly Pro Thr 
    1730                 1735                 1740             


Gln Thr  Leu Ser Leu Ala Pro  Ala Pro Pro Leu Ala  Pro Ala Ser 
    1745                 1750                 1755             


Pro Val  Gly Pro Ala Pro Ala  His Thr Leu Thr Leu  Ala Pro Ala 
    1760                 1765                 1770             


Ser Ser  Ser Ala Ser Leu Leu  Ala Pro Ala Ser Val  Gln Thr Leu 
    1775                 1780                 1785             


Thr Leu  Ser Pro Ala Pro Val  Pro Thr Leu Gly Pro  Ala Ala Ala 
    1790                 1795                 1800             


Gln Thr  Leu Ala Leu Ala Pro  Ala Ser Thr Gln Ser  Pro Ala Ser 
    1805                 1810                 1815             


Gln Ala  Ser Ser Leu Val Val  Ser Ala Ser Gly Ala  Ala Pro Leu 
    1820                 1825                 1830             


Pro Val  Thr Met Val Ser Arg  Leu Pro Val Ser Lys  Asp Glu Pro 
    1835                 1840                 1845             


Asp Thr  Leu Thr Leu Arg Ser  Gly Pro Pro Ser Pro  Pro Ser Thr 
    1850                 1855                 1860             


Ala Thr  Ser Phe Gly Gly Pro  Arg Pro Arg Arg Gln  Pro Pro Pro 
    1865                 1870                 1875             


Pro Pro  Arg Ser Pro Phe Tyr  Leu Asp Ser Leu Glu  Glu Lys Arg 
    1880                 1885                 1890             


Lys Arg  Gln Arg Ser Glu Arg  Leu Glu Arg Ile Phe  Gln Leu Ser 
    1895                 1900                 1905             


Glu Ala  His Gly Ala Leu Ala  Pro Val Tyr Gly Thr  Glu Val Leu 
    1910                 1915                 1920             


Asp Phe  Cys Thr Leu Pro Gln  Pro Val Ala Ser Pro  Ile Gly Pro 
    1925                 1930                 1935             


Arg Ser  Pro Gly Pro Ser His  Pro Thr Phe Trp Thr  Tyr Thr Glu 
    1940                 1945                 1950             


Ala Ala  His Arg Ala Val Leu  Phe Pro Gln Gln Arg  Leu Asp Gln 
    1955                 1960                 1965             


Leu Ser  Glu Ile Ile Glu Arg  Phe Ile Phe Val Met  Pro Pro Val 
    1970                 1975                 1980             


Glu Ala  Pro Pro Pro Ser Leu  His Ala Cys His Pro  Pro Pro Trp 
    1985                 1990                 1995             


Leu Ala  Pro Arg Gln Ala Ala  Phe Gln Glu Gln Leu  Ala Ser Glu 
    2000                 2005                 2010             


Leu Trp  Pro Arg Ala Arg Pro  Leu His Arg Ile Val  Cys Asn Met 
    2015                 2020                 2025             


Arg Thr  Gln Phe Pro Asp Leu  Arg Leu Ile Gln Tyr  Asp Cys Gly 
    2030                 2035                 2040             


Lys Leu  Gln Thr Leu Ala Val  Leu Leu Arg Gln Leu  Lys Ala Glu 
    2045                 2050                 2055             


Gly His  Arg Val Leu Ile Phe  Thr Gln Met Thr Arg  Met Leu Asp 
    2060                 2065                 2070             


Val Leu  Glu Gln Phe Leu Thr  Tyr His Gly His Leu  Tyr Leu Arg 
    2075                 2080                 2085             


Leu Asp  Gly Ser Thr Arg Val  Glu Gln Arg Gln Ala  Leu Met Glu 
    2090                 2095                 2100             


Arg Phe  Asn Ala Asp Lys Arg  Ile Phe Cys Phe Ile  Leu Ser Thr 
    2105                 2110                 2115             


Arg Ser  Gly Gly Val Gly Val  Asn Leu Thr Gly Ala  Asp Thr Val 
    2120                 2125                 2130             


Val Phe  Tyr Asp Ser Asp Trp  Asn Pro Thr Met Asp  Ala Gln Ala 
    2135                 2140                 2145             


Gln Asp  Arg Cys His Arg Ile  Gly Gln Thr Arg Asp  Val His Ile 
    2150                 2155                 2160             


Tyr Arg  Leu Ile Ser Glu Arg  Thr Val Glu Glu Asn  Ile Leu Lys 
    2165                 2170                 2175             


Lys Ala  Asn Gln Lys Arg Met  Leu Gly Asp Met Ala  Ile Glu Gly 
    2180                 2185                 2190             


Gly Asn  Phe Thr Thr Ala Tyr  Phe Lys Gln Gln Thr  Ile Arg Glu 
    2195                 2200                 2205             


Leu Phe  Asp Met Pro Leu Glu  Glu Pro Ser Ser Ser  Ser Val Pro 
    2210                 2215                 2220             


Ser Ala  Pro Glu Glu Glu Glu  Glu Thr Val Ala Ser  Lys Gln Thr 
    2225                 2230                 2235             


His Ile  Leu Glu Gln Ala Leu  Cys Arg Ala Glu Asp  Glu Glu Asp 
    2240                 2245                 2250             


Ile Arg  Ala Ala Thr Gln Ala  Lys Ala Glu Gln Val  Ala Glu Leu 
    2255                 2260                 2265             


Ala Glu  Phe Asn Glu Asn Asp  Gly Phe Pro Ala Gly  Glu Gly Glu 
    2270                 2275                 2280             


Glu Ala  Gly Arg Pro Gly Ala  Glu Asp Glu Glu Met  Ser Arg Ala 
    2285                 2290                 2295             


Glu Gln  Glu Ile Ala Ala Leu  Val Glu Gln Leu Thr  Pro Ile Glu 
    2300                 2305                 2310             


Arg Tyr  Ala Met Lys Phe Leu  Glu Ala Ser Leu Glu  Glu Val Ser 
    2315                 2320                 2325             


Arg Glu  Glu Leu Lys Gln Ala  Glu Glu Gln Val Glu  Ala Ala Arg 
    2330                 2335                 2340             


Lys Asp  Leu Asp Gln Ala Lys  Glu Glu Val Phe Arg  Leu Pro Gln 
    2345                 2350                 2355             


Glu Glu  Glu Glu Gly Pro Gly  Ala Gly Asp Glu Ser  Ser Cys Gly 
    2360                 2365                 2370             


Thr Gly  Gly Gly Thr His Arg  Arg Ser Lys Lys Ala  Lys Ala Pro 
    2375                 2380                 2385             


Glu Arg  Pro Gly Thr Arg Val  Ser Glu Arg Leu Arg  Gly Ala Arg 
    2390                 2395                 2400             


Ala Glu  Thr Gln Gly Ala Asn  His Thr Pro Val Ile  Ser Ala His 
    2405                 2410                 2415             


Gln Thr  Arg Ser Thr Thr Thr  Pro Pro Arg Cys Ser  Pro Ala Arg 
    2420                 2425                 2430             


Glu Arg  Val Pro Arg Pro Ala  Pro Arg Pro Arg Pro  Thr Pro Ala 
    2435                 2440                 2445             


Ser Ala  Pro Ala Ala Ile Pro  Ala Leu Val Pro Val  Pro Val Ser 
    2450                 2455                 2460             


Ala Pro  Val Pro Ile Ser Ala  Pro Asn Pro Ile Thr  Ile Leu Pro 
    2465                 2470                 2475             


Val His  Ile Leu Pro Ser Pro  Pro Pro Pro Ser Gln  Ile Pro Pro 
    2480                 2485                 2490             


Cys Ser  Ser Pro Ala Cys Thr  Pro Pro Pro Ala Cys  Thr Pro Pro 
    2495                 2500                 2505             


Pro Ala  His Thr Pro Pro Pro  Ala Gln Thr Cys Leu  Val Thr Pro 
    2510                 2515                 2520             


Ser Ser  Pro Leu Leu Leu Gly  Pro Pro Ser Val Pro  Ile Ser Ala 
    2525                 2530                 2535             


Ser Val  Thr Asn Leu Pro Leu  Gly Leu Arg Pro Glu  Ala Glu Leu 
    2540                 2545                 2550             


Cys Ala  Gln Ala Leu Ala Ser  Pro Glu Ser Leu Glu  Leu Ala Ser 
    2555                 2560                 2565             


Val Ala  Ser Ser Glu Thr Ser  Ser Leu Ser Leu Val  Pro Pro Lys 
    2570                 2575                 2580             


Asp Leu  Leu Pro Val Ala Val  Glu Ile Leu Pro Val  Ser Glu Lys 
    2585                 2590                 2595             


Asn Leu  Ser Leu Thr Pro Ser  Ala Pro Ser Leu Thr  Leu Glu Ala 
    2600                 2605                 2610             


Gly Ser  Ile Pro Asn Gly Gln  Glu Gln Glu Ala Pro  Asp Ser Ala 
    2615                 2620                 2625             


Glu Gly  Thr Thr Leu Thr Val  Leu Pro Glu Gly Glu  Glu Leu Pro 
    2630                 2635                 2640             


Leu Cys  Val Ser Glu Ser Asn  Gly Leu Glu Leu Pro  Pro Ser Ala 
    2645                 2650                 2655             


Ala Ser  Asp Glu Pro Leu Gln  Glu Pro Leu Glu Ala  Asp Arg Thr 
    2660                 2665                 2670             


Ser Glu  Glu Leu Thr Glu Ala  Lys Thr Pro Thr Ser  Ser Pro Glu 
    2675                 2680                 2685             


Lys Pro  Gln Glu Leu Val Thr  Ala Glu Val Ala Ala  Pro Ser Thr 
    2690                 2695                 2700             


Ser Ser  Ser Ala Thr Ser Ser  Pro Glu Gly Pro Ser  Pro Ala Arg 
    2705                 2710                 2715             


Pro Pro  Arg Arg Arg Thr Ser  Ala Asp Val Glu Ile  Arg Gly Gln 
    2720                 2725                 2730             


Gly Thr  Gly Arg Pro Gly Gln  Pro Pro Gly Pro Lys  Val Leu Arg 
    2735                 2740                 2745             


Lys Leu  Pro Gly Arg Leu Val  Thr Val Val Glu Glu  Lys Glu Leu 
    2750                 2755                 2760             


Val Arg  Arg Arg Arg Gln Gln  Arg Gly Ala Ala Ser  Thr Leu Val 
    2765                 2770                 2775             


Pro Gly  Val Ser Glu Thr Ser  Ala Ser Pro Gly Ser  Pro Ser Val 
    2780                 2785                 2790             


Arg Ser  Met Ser Gly Pro Glu  Ser Ser Pro Pro Ile  Gly Gly Pro 
    2795                 2800                 2805             


Cys Glu  Ala Ala Pro Ser Ser  Ser Leu Pro Thr Pro  Pro Gln Gln 
    2810                 2815                 2820             


Pro Phe  Ile Ala Arg Arg His  Ile Glu Leu Gly Val  Thr Gly Gly 
    2825                 2830                 2835             


Gly Ser  Pro Glu Asn Gly Asp  Gly Ala Leu Leu Ala  Ile Thr Pro 
    2840                 2845                 2850             


Pro Ala  Val Lys Arg Arg Arg  Gly Arg Pro Pro Lys  Lys Asn Arg 
    2855                 2860                 2865             


Ser Pro  Ala Asp Ala Gly Arg  Gly Val Asp Glu Ala  Pro Ser Ser 
    2870                 2875                 2880             


Thr Leu  Lys Gly Lys Thr Asn  Gly Ala Asp Pro Val  Pro Gly Pro 
    2885                 2890                 2895             


Glu Thr  Leu Ile Val Ala Asp  Pro Val Leu Glu Pro  Gln Leu Ile 
    2900                 2905                 2910             


Pro Gly  Pro Gln Pro Leu Gly  Pro Gln Pro Val His  Arg Pro Asn 
    2915                 2920                 2925             


Pro Leu  Leu Ser Pro Val Glu  Lys Arg Arg Arg Gly  Arg Pro Pro 
    2930                 2935                 2940             


Lys Ala  Arg Asp Leu Pro Ile  Pro Gly Thr Ile Ser  Ser Ala Gly 
    2945                 2950                 2955             


Asp Gly  Asn Ser Glu Ser Arg  Thr Gln Pro Pro Pro  His Pro Ser 
    2960                 2965                 2970             


Pro Leu  Thr Pro Leu Pro Pro  Leu Leu Val Cys Pro  Thr Ala Thr 
    2975                 2980                 2985             


Val Ala  Asn Thr Val Thr Thr  Val Thr Ile Ser Thr  Ser Pro Pro 
    2990                 2995                 3000             


Lys Arg  Lys Arg Gly Arg Pro  Pro Lys Asn Pro Pro  Ser Pro Arg 
    3005                 3010                 3015             


Pro Ser  Gln Leu Pro Val Leu  Asp Arg Asp Ser Thr  Ser Val Leu 
    3020                 3025                 3030             


Glu Ser  Cys Gly Leu Gly Arg  Arg Arg Gln Pro Gln  Gly Gln Gly 
    3035                 3040                 3045             


Glu Ser  Glu Gly Ser Ser Ser  Asp Glu Asp Gly Ser  Arg Pro Leu 
    3050                 3055                 3060             


Thr Arg  Leu Ala Arg Leu Arg  Leu Glu Ala Glu Gly  Met Arg Gly 
    3065                 3070                 3075             


Arg Lys  Ser Gly Gly Ser Met  Val Val Ala Val Ile  Gln Asp Asp 
    3080                 3085                 3090             


Leu Asp  Leu Ala Asp Ser Gly  Pro Gly Gly Leu Glu  Leu Thr Pro 
    3095                 3100                 3105             


Pro Val  Val Ser Leu Thr Pro  Lys Leu Arg Ser Thr  Arg Leu Arg 
    3110                 3115                 3120             


Pro Gly  Ser Leu Val Pro Pro  Leu Glu Thr Glu Lys  Leu Pro Arg 
    3125                 3130                 3135             


Lys Arg  Ala Gly Ala Pro Val  Gly Gly Ser Pro Gly  Leu Ala Lys 
    3140                 3145                 3150             


Arg Gly  Arg Leu Gln Pro Pro  Ser Pro Leu Gly Pro  Glu Gly Ser 
    3155                 3160                 3165             


Val Glu  Glu Ser Glu Ala Glu  Ala Ser Gly Glu Glu  Glu Glu Gly 
    3170                 3175                 3180             


Asp Gly  Thr Pro Arg Arg Arg  Pro Gly Pro Arg Arg  Leu Val Gly 
    3185                 3190                 3195             


Thr Thr  Asn Gln Gly Asp Gln  Arg Ile Leu Arg Ser  Ser Ala Pro 
    3200                 3205                 3210             


Pro Ser  Leu Ala Gly Pro Ala  Val Ser His Arg Gly  Arg Lys Ala 
    3215                 3220                 3225             


Lys Thr  
    3230 


<210>  15
<211>  280
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Cys Ser Ala Phe His Arg Ala Glu Ser Gly Thr Glu Leu Leu Ala 
1               5                   10                  15      


Arg Leu Glu Gly Arg Ser Ser Leu Lys Glu Ile Glu Pro Asn Leu Phe 
            20                  25                  30          


Ala Asp Glu Asp Ser Pro Val His Gly Asp Ile Leu Glu Phe His Gly 
        35                  40                  45              


Pro Glu Gly Thr Gly Lys Thr Glu Met Leu Tyr His Leu Thr Ala Arg 
    50                  55                  60                  


Cys Ile Leu Pro Lys Ser Glu Gly Gly Leu Glu Val Glu Val Leu Phe 
65                  70                  75                  80  


Ile Asp Thr Asp Tyr His Phe Asp Met Leu Arg Leu Val Thr Ile Leu 
                85                  90                  95      


Glu His Arg Leu Ser Gln Ser Ser Glu Glu Ile Ile Lys Tyr Cys Leu 
            100                 105                 110         


Gly Arg Phe Phe Leu Val Tyr Cys Ser Ser Ser Thr His Leu Leu Leu 
        115                 120                 125             


Thr Leu Tyr Ser Leu Glu Ser Met Phe Cys Ser His Pro Ser Leu Cys 
    130                 135                 140                 


Leu Leu Ile Leu Asp Ser Leu Ser Ala Phe Tyr Trp Ile Asp Arg Val 
145                 150                 155                 160 


Asn Gly Gly Glu Ser Val Asn Leu Gln Glu Ser Thr Leu Arg Lys Cys 
                165                 170                 175     


Ser Gln Cys Leu Glu Lys Leu Val Asn Asp Tyr Arg Leu Val Leu Phe 
            180                 185                 190         


Ala Thr Thr Gln Thr Ile Met Gln Lys Ala Ser Ser Ser Ser Glu Glu 
        195                 200                 205             


Pro Ser His Ala Ser Arg Arg Leu Cys Asp Val Asp Ile Asp Tyr Arg 
    210                 215                 220                 


Pro Tyr Leu Cys Lys Ala Trp Gln Gln Leu Val Lys His Arg Met Phe 
225                 230                 235                 240 


Phe Ser Lys Gln Asp Asp Ser Gln Ser Ser Asn Gln Phe Ser Leu Val 
                245                 250                 255     


Ser Arg Cys Leu Lys Ser Asn Ser Leu Lys Lys His Phe Phe Ile Ile 
            260                 265                 270         


Gly Glu Ser Gly Val Glu Phe Cys 
        275                 280 


<210>  16
<211>  1137
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Ser Arg Arg Lys Pro Ala Ser Gly Gly Leu Ala Ala Ser Ser Ser 
1               5                   10                  15      


Ala Pro Ala Arg Gln Ala Val Leu Ser Arg Phe Phe Gln Ser Thr Gly 
            20                  25                  30          


Ser Leu Lys Ser Thr Ser Ser Ser Thr Gly Ala Ala Asp Gln Val Asp 
        35                  40                  45              


Pro Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Pro Pro 
    50                  55                  60                  


Ala Pro Pro Ala Pro Ala Phe Pro Pro Gln Leu Pro Pro His Ile Ala 
65                  70                  75                  80  


Thr Glu Ile Asp Arg Arg Lys Lys Arg Pro Leu Glu Asn Asp Gly Pro 
                85                  90                  95      


Val Lys Lys Lys Val Lys Lys Val Gln Gln Lys Glu Gly Gly Ser Asp 
            100                 105                 110         


Leu Gly Met Ser Gly Asn Ser Glu Pro Lys Lys Cys Leu Arg Thr Arg 
        115                 120                 125             


Asn Val Ser Lys Ser Leu Glu Lys Leu Lys Glu Phe Cys Cys Asp Ser 
    130                 135                 140                 


Ala Leu Pro Gln Ser Arg Val Gln Thr Glu Ser Leu Gln Glu Arg Phe 
145                 150                 155                 160 


Ala Val Leu Pro Lys Cys Thr Asp Phe Asp Asp Ile Ser Leu Leu His 
                165                 170                 175     


Ala Lys Asn Ala Val Ser Ser Glu Asp Ser Lys Arg Gln Ile Asn Gln 
            180                 185                 190         


Lys Asp Thr Thr Leu Phe Asp Leu Ser Gln Phe Gly Ser Ser Asn Thr 
        195                 200                 205             


Ser His Glu Asn Leu Gln Lys Thr Ala Ser Lys Ser Ala Asn Lys Arg 
    210                 215                 220                 


Ser Lys Ser Ile Tyr Thr Pro Leu Glu Leu Gln Tyr Ile Glu Met Lys 
225                 230                 235                 240 


Gln Gln His Lys Asp Ala Val Leu Cys Val Glu Cys Gly Tyr Lys Tyr 
                245                 250                 255     


Arg Phe Phe Gly Glu Asp Ala Glu Ile Ala Ala Arg Glu Leu Asn Ile 
            260                 265                 270         


Tyr Cys His Leu Asp His Asn Phe Met Thr Ala Ser Ile Pro Thr His 
        275                 280                 285             


Arg Leu Phe Val His Val Arg Arg Leu Val Ala Lys Gly Tyr Lys Val 
    290                 295                 300                 


Gly Val Val Lys Gln Thr Glu Thr Ala Ala Leu Lys Ala Ile Gly Asp 
305                 310                 315                 320 


Asn Arg Ser Ser Leu Phe Ser Arg Lys Leu Thr Ala Leu Tyr Thr Lys 
                325                 330                 335     


Ser Thr Leu Ile Gly Glu Asp Val Asn Pro Leu Ile Lys Leu Asp Asp 
            340                 345                 350         


Ala Val Asn Val Asp Glu Ile Met Thr Asp Thr Ser Thr Ser Tyr Leu 
        355                 360                 365             


Leu Cys Ile Ser Glu Asn Lys Glu Asn Val Arg Asp Lys Lys Lys Gly 
    370                 375                 380                 


Asn Ile Phe Ile Gly Ile Val Gly Val Gln Pro Ala Thr Gly Glu Val 
385                 390                 395                 400 


Val Phe Asp Ser Phe Gln Asp Ser Ala Ser Arg Ser Glu Leu Glu Thr 
                405                 410                 415     


Arg Met Ser Ser Leu Gln Pro Val Glu Leu Leu Leu Pro Ser Ala Leu 
            420                 425                 430         


Ser Glu Gln Thr Glu Ala Leu Ile His Arg Ala Thr Ser Val Ser Val 
        435                 440                 445             


Gln Asp Asp Arg Ile Arg Val Glu Arg Met Asp Asn Ile Tyr Phe Glu 
    450                 455                 460                 


Tyr Ser His Ala Phe Gln Ala Val Thr Glu Phe Tyr Ala Lys Asp Thr 
465                 470                 475                 480 


Val Asp Ile Lys Gly Ser Gln Ile Ile Ser Gly Ile Val Asn Leu Glu 
                485                 490                 495     


Lys Pro Val Ile Cys Ser Leu Ala Ala Ile Ile Lys Tyr Leu Lys Glu 
            500                 505                 510         


Phe Asn Leu Glu Lys Met Leu Ser Lys Pro Glu Asn Phe Lys Gln Leu 
        515                 520                 525             


Ser Ser Lys Met Glu Phe Met Thr Ile Asn Gly Thr Thr Leu Arg Asn 
    530                 535                 540                 


Leu Glu Ile Leu Gln Asn Gln Thr Asp Met Lys Thr Lys Gly Ser Leu 
545                 550                 555                 560 


Leu Trp Val Leu Asp His Thr Lys Thr Ser Phe Gly Arg Arg Lys Leu 
                565                 570                 575     


Lys Lys Trp Val Thr Gln Pro Leu Leu Lys Leu Arg Glu Ile Asn Ala 
            580                 585                 590         


Arg Leu Asp Ala Val Ser Glu Val Leu His Ser Glu Ser Ser Val Phe 
        595                 600                 605             


Gly Gln Ile Glu Asn His Leu Arg Lys Leu Pro Asp Ile Glu Arg Gly 
    610                 615                 620                 


Leu Cys Ser Ile Tyr His Lys Lys Cys Ser Thr Gln Glu Phe Phe Leu 
625                 630                 635                 640 


Ile Val Lys Thr Leu Tyr His Leu Lys Ser Glu Phe Gln Ala Ile Ile 
                645                 650                 655     


Pro Ala Val Asn Ser His Ile Gln Ser Asp Leu Leu Arg Thr Val Ile 
            660                 665                 670         


Leu Glu Ile Pro Glu Leu Leu Ser Pro Val Glu His Tyr Leu Lys Ile 
        675                 680                 685             


Leu Asn Glu Gln Ala Ala Lys Val Gly Asp Lys Thr Glu Leu Phe Lys 
    690                 695                 700                 


Asp Leu Ser Asp Phe Pro Leu Ile Lys Lys Arg Lys Asp Glu Ile Gln 
705                 710                 715                 720 


Gly Val Ile Asp Glu Ile Arg Met His Leu Gln Glu Ile Arg Lys Ile 
                725                 730                 735     


Leu Lys Asn Pro Ser Ala Gln Tyr Val Thr Val Ser Gly Gln Glu Phe 
            740                 745                 750         


Met Ile Glu Ile Lys Asn Ser Ala Val Ser Cys Ile Pro Thr Asp Trp 
        755                 760                 765             


Val Lys Val Gly Ser Thr Lys Ala Val Ser Arg Phe His Ser Pro Phe 
    770                 775                 780                 


Ile Val Glu Asn Tyr Arg His Leu Asn Gln Leu Arg Glu Gln Leu Val 
785                 790                 795                 800 


Leu Asp Cys Ser Ala Glu Trp Leu Asp Phe Leu Glu Lys Phe Ser Glu 
                805                 810                 815     


His Tyr His Ser Leu Cys Lys Ala Val His His Leu Ala Thr Val Asp 
            820                 825                 830         


Cys Ile Phe Ser Leu Ala Lys Val Ala Lys Gln Gly Asp Tyr Cys Arg 
        835                 840                 845             


Pro Thr Val Gln Glu Glu Arg Lys Ile Val Ile Lys Asn Gly Arg His 
    850                 855                 860                 


Pro Val Ile Asp Val Leu Leu Gly Glu Gln Asp Gln Tyr Val Pro Asn 
865                 870                 875                 880 


Asn Thr Asp Leu Ser Glu Asp Ser Glu Arg Val Met Ile Ile Thr Gly 
                885                 890                 895     


Pro Asn Met Gly Gly Lys Ser Ser Tyr Ile Lys Gln Val Ala Leu Ile 
            900                 905                 910         


Thr Ile Met Ala Gln Ile Gly Ser Tyr Val Pro Ala Glu Glu Ala Thr 
        915                 920                 925             


Ile Gly Ile Val Asp Gly Ile Phe Thr Arg Met Gly Ala Ala Asp Asn 
    930                 935                 940                 


Ile Tyr Lys Gly Gln Ser Thr Phe Met Glu Glu Leu Thr Asp Thr Ala 
945                 950                 955                 960 


Glu Ile Ile Arg Lys Ala Thr Ser Gln Ser Leu Val Ile Leu Asp Glu 
                965                 970                 975     


Leu Gly Arg Gly Thr Ser Thr His Asp Gly Ile Ala Ile Ala Tyr Ala 
            980                 985                 990         


Thr Leu Glu Tyr Phe Ile Arg Asp  Val Lys Ser Leu Thr  Leu Phe Val 
        995                 1000                 1005             


Thr His  Tyr Pro Pro Val Cys  Glu Leu Glu Lys Asn  Tyr Ser His 
    1010                 1015                 1020             


Gln Val  Gly Asn Tyr His Met  Gly Phe Leu Val Ser  Glu Asp Glu 
    1025                 1030                 1035             


Ser Lys  Leu Asp Pro Gly Ala  Ala Glu Gln Val Pro  Asp Phe Val 
    1040                 1045                 1050             


Thr Phe  Leu Tyr Gln Ile Thr  Arg Gly Ile Ala Ala  Arg Ser Tyr 
    1055                 1060                 1065             


Gly Leu  Asn Val Ala Lys Leu  Ala Asp Val Pro Gly  Glu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Ala Ala His Lys Ser  Lys Glu Leu Glu Gly  Leu Ile Asn 
    1085                 1090                 1095             


Thr Lys  Arg Lys Arg Leu Lys  Tyr Phe Ala Lys Leu  Trp Thr Met 
    1100                 1105                 1110             


His Asn  Ala Gln Asp Leu Gln  Lys Trp Thr Glu Glu  Phe Asn Met 
    1115                 1120                 1125             


Glu Glu  Thr Gln Thr Ser Leu  Leu His 
    1130                 1135         


<210>  17
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Glu Val Glu Ala Val Cys Gly Gly Ala Gly Glu Val Glu Ala Gln 
1               5                   10                  15      


Asp Ser Asp Pro Ala Pro Ala Phe Ser Lys Ala Pro Gly Ser Ala Gly 
            20                  25                  30          


His Tyr Glu Leu Pro Trp Val Glu Lys Tyr Arg Pro Val Lys Leu Asn 
        35                  40                  45              


Glu Ile Val Gly Asn Glu Asp Thr Val Ser Arg Leu Glu Val Phe Ala 
    50                  55                  60                  


Arg Glu Gly Asn Val Pro Asn Ile Ile Ile Ala Gly Pro Pro Gly Thr 
65                  70                  75                  80  


Gly Lys Thr Thr Ser Ile Leu Cys Leu Ala Arg Ala Leu Leu Gly Pro 
                85                  90                  95      


Ala Leu Lys Asp Ala Met Leu Glu Leu Asn Ala Ser Asn Asp Arg Gly 
            100                 105                 110         


Ile Asp Val Val Arg Asn Lys Ile Lys Met Phe Ala Gln Gln Lys Val 
        115                 120                 125             


Thr Leu Pro Lys Gly Arg His Lys Ile Ile Ile Leu Asp Glu Ala Asp 
    130                 135                 140                 


Ser Met Thr Asp Gly Ala Gln Gln Ala Leu Arg Arg Thr Met Glu Ile 
145                 150                 155                 160 


Tyr Ser Lys Thr Thr Arg Phe Ala Leu Ala Cys Asn Ala Ser Asp Lys 
                165                 170                 175     


Ile Ile Glu Pro Ile Gln Ser Arg Cys Ala Val Leu Arg Tyr Thr Lys 
            180                 185                 190         


Leu Thr Asp Ala Gln Ile Leu Thr Arg Leu Met Asn Val Ile Glu Lys 
        195                 200                 205             


Glu Arg Val Pro Tyr Thr Asp Asp Gly Leu Glu Ala Ile Ile Phe Thr 
    210                 215                 220                 


Ala Gln Gly Asp Met Arg Gln Ala Leu Asn Asn Leu Gln Ser Thr Phe 
225                 230                 235                 240 


Ser Gly Phe Gly Phe Ile Asn Ser Glu Asn Val Phe Lys Val Cys Asp 
                245                 250                 255     


Glu Pro His Pro Leu Leu Val Lys Glu Met Ile Gln His Cys Val Asn 
            260                 265                 270         


Ala Asn Ile Asp Glu Ala Tyr Lys Ile Leu Ala His Leu Trp His Leu 
        275                 280                 285             


Gly Tyr Ser Pro Glu Asp Ile Ile Gly Asn Ile Phe Arg Val Cys Lys 
    290                 295                 300                 


Thr Phe Gln Met Ala Glu Tyr Leu Lys Leu Glu Phe Ile Lys Glu Ile 
305                 310                 315                 320 


Gly Tyr Thr His Met Lys Ile Ala Glu Gly Val Asn Ser Leu Leu Gln 
                325                 330                 335     


Met Ala Gly Leu Leu Ala Arg Leu Cys Gln Lys Thr Met Ala Pro Val 
            340                 345                 350         


Ala Ser 
        


<210>  18
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Ala Ala Ala Ala Ala Ala Ala Ala Thr Asn Gly Thr Gly Gly 
1               5                   10                  15      


Ser Ser Gly Met Glu Val Asp Ala Ala Val Val Pro Ser Val Met Ala 
            20                  25                  30          


Cys Gly Val Thr Gly Ser Val Ser Val Ala Leu His Pro Leu Val Ile 
        35                  40                  45              


Leu Asn Ile Ser Asp His Trp Ile Arg Met Arg Ser Gln Glu Gly Arg 
    50                  55                  60                  


Pro Val Gln Val Ile Gly Ala Leu Ile Gly Lys Gln Glu Gly Arg Asn 
65                  70                  75                  80  


Ile Glu Val Met Asn Ser Phe Glu Leu Leu Ser His Thr Val Glu Glu 
                85                  90                  95      


Lys Ile Ile Ile Asp Lys Glu Tyr Tyr Tyr Thr Lys Glu Glu Gln Phe 
            100                 105                 110         


Lys Gln Val Phe Lys Glu Leu Glu Phe Leu Gly Trp Tyr Thr Thr Gly 
        115                 120                 125             


Gly Pro Pro Asp Pro Ser Asp Ile His Val His Lys Gln Val Cys Glu 
    130                 135                 140                 


Ile Ile Glu Ser Pro Leu Phe Leu Lys Leu Asn Pro Met Thr Lys His 
145                 150                 155                 160 


Thr Asp Leu Pro Val Ser Val Phe Glu Ser Val Ile Asp Ile Ile Asn 
                165                 170                 175     


Gly Glu Ala Thr Met Leu Phe Ala Glu Leu Thr Tyr Thr Leu Ala Thr 
            180                 185                 190         


Glu Glu Ala Glu Arg Ile Gly Val Asp His Val Ala Arg Met Thr Ala 
        195                 200                 205             


Thr Gly Ser Gly Glu Asn Ser Thr Val Ala Glu His Leu Ile Ala Gln 
    210                 215                 220                 


His Ser Ala Ile Lys Met Leu His Ser Arg Val Lys Leu Ile Leu Glu 
225                 230                 235                 240 


Tyr Val Lys Ala Ser Glu Ala Gly Glu Val Pro Phe Asn His Glu Ile 
                245                 250                 255     


Leu Arg Glu Ala Tyr Ala Leu Cys His Cys Leu Pro Val Leu Ser Thr 
            260                 265                 270         


Asp Lys Phe Lys Thr Asp Phe Tyr Asp Gln Cys Asn Asp Val Gly Leu 
        275                 280                 285             


Met Ala Tyr Leu Gly Thr Ile Thr Lys Thr Cys Asn Thr Met Asn Gln 
    290                 295                 300                 


Phe Val Asn Lys Phe Asn Val Leu Tyr Asp Arg Gln Gly Ile Gly Arg 
305                 310                 315                 320 


Arg Met Arg Gly Leu Phe Phe 
                325         


<210>  19
<211>  2414
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Glu Asn Val Val Glu Pro Gly Pro Pro Ser Ala Lys Arg Pro 
1               5                   10                  15      


Lys Leu Ser Ser Pro Ala Leu Ser Ala Ser Ala Ser Asp Gly Thr Asp 
            20                  25                  30          


Phe Gly Ser Leu Phe Asp Leu Glu His Asp Leu Pro Asp Glu Leu Ile 
        35                  40                  45              


Asn Ser Thr Glu Leu Gly Leu Thr Asn Gly Gly Asp Ile Asn Gln Leu 
    50                  55                  60                  


Gln Thr Ser Leu Gly Met Val Gln Asp Ala Ala Ser Lys His Lys Gln 
65                  70                  75                  80  


Leu Ser Glu Leu Leu Arg Ser Gly Ser Ser Pro Asn Leu Asn Met Gly 
                85                  90                  95      


Val Gly Gly Pro Gly Gln Val Met Ala Ser Gln Ala Gln Gln Ser Ser 
            100                 105                 110         


Pro Gly Leu Gly Leu Ile Asn Ser Met Val Lys Ser Pro Met Thr Gln 
        115                 120                 125             


Ala Gly Leu Thr Ser Pro Asn Met Gly Met Gly Thr Ser Gly Pro Asn 
    130                 135                 140                 


Gln Gly Pro Thr Gln Ser Thr Gly Met Met Asn Ser Pro Val Asn Gln 
145                 150                 155                 160 


Pro Ala Met Gly Met Asn Thr Gly Met Asn Ala Gly Met Asn Pro Gly 
                165                 170                 175     


Met Leu Ala Ala Gly Asn Gly Gln Gly Ile Met Pro Asn Gln Val Met 
            180                 185                 190         


Asn Gly Ser Ile Gly Ala Gly Arg Gly Arg Gln Asn Met Gln Tyr Pro 
        195                 200                 205             


Asn Pro Gly Met Gly Ser Ala Gly Asn Leu Leu Thr Glu Pro Leu Gln 
    210                 215                 220                 


Gln Gly Ser Pro Gln Met Gly Gly Gln Thr Gly Leu Arg Gly Pro Gln 
225                 230                 235                 240 


Pro Leu Lys Met Gly Met Met Asn Asn Pro Asn Pro Tyr Gly Ser Pro 
                245                 250                 255     


Tyr Thr Gln Asn Pro Gly Gln Gln Ile Gly Ala Ser Gly Leu Gly Leu 
            260                 265                 270         


Gln Ile Gln Thr Lys Thr Val Leu Ser Asn Asn Leu Ser Pro Phe Ala 
        275                 280                 285             


Met Asp Lys Lys Ala Val Pro Gly Gly Gly Met Pro Asn Met Gly Gln 
    290                 295                 300                 


Gln Pro Ala Pro Gln Val Gln Gln Pro Gly Leu Val Thr Pro Val Ala 
305                 310                 315                 320 


Gln Gly Met Gly Ser Gly Ala His Thr Ala Asp Pro Glu Lys Arg Lys 
                325                 330                 335     


Leu Ile Gln Gln Gln Leu Val Leu Leu Leu His Ala His Lys Cys Gln 
            340                 345                 350         


Arg Arg Glu Gln Ala Asn Gly Glu Val Arg Gln Cys Asn Leu Pro His 
        355                 360                 365             


Cys Arg Thr Met Lys Asn Val Leu Asn His Met Thr His Cys Gln Ser 
    370                 375                 380                 


Gly Lys Ser Cys Gln Val Ala His Cys Ala Ser Ser Arg Gln Ile Ile 
385                 390                 395                 400 


Ser His Trp Lys Asn Cys Thr Arg His Asp Cys Pro Val Cys Leu Pro 
                405                 410                 415     


Leu Lys Asn Ala Gly Asp Lys Arg Asn Gln Gln Pro Ile Leu Thr Gly 
            420                 425                 430         


Ala Pro Val Gly Leu Gly Asn Pro Ser Ser Leu Gly Val Gly Gln Gln 
        435                 440                 445             


Ser Ala Pro Asn Leu Ser Thr Val Ser Gln Ile Asp Pro Ser Ser Ile 
    450                 455                 460                 


Glu Arg Ala Tyr Ala Ala Leu Gly Leu Pro Tyr Gln Val Asn Gln Met 
465                 470                 475                 480 


Pro Thr Gln Pro Gln Val Gln Ala Lys Asn Gln Gln Asn Gln Gln Pro 
                485                 490                 495     


Gly Gln Ser Pro Gln Gly Met Arg Pro Met Ser Asn Met Ser Ala Ser 
            500                 505                 510         


Pro Met Gly Val Asn Gly Gly Val Gly Val Gln Thr Pro Ser Leu Leu 
        515                 520                 525             


Ser Asp Ser Met Leu His Ser Ala Ile Asn Ser Gln Asn Pro Met Met 
    530                 535                 540                 


Ser Glu Asn Ala Ser Val Pro Ser Leu Gly Pro Met Pro Thr Ala Ala 
545                 550                 555                 560 


Gln Pro Ser Thr Thr Gly Ile Arg Lys Gln Trp His Glu Asp Ile Thr 
                565                 570                 575     


Gln Asp Leu Arg Asn His Leu Val His Lys Leu Val Gln Ala Ile Phe 
            580                 585                 590         


Pro Thr Pro Asp Pro Ala Ala Leu Lys Asp Arg Arg Met Glu Asn Leu 
        595                 600                 605             


Val Ala Tyr Ala Arg Lys Val Glu Gly Asp Met Tyr Glu Ser Ala Asn 
    610                 615                 620                 


Asn Arg Ala Glu Tyr Tyr His Leu Leu Ala Glu Lys Ile Tyr Lys Ile 
625                 630                 635                 640 


Gln Lys Glu Leu Glu Glu Lys Arg Arg Thr Arg Leu Gln Lys Gln Asn 
                645                 650                 655     


Met Leu Pro Asn Ala Ala Gly Met Val Pro Val Ser Met Asn Pro Gly 
            660                 665                 670         


Pro Asn Met Gly Gln Pro Gln Pro Gly Met Thr Ser Asn Gly Pro Leu 
        675                 680                 685             


Pro Asp Pro Ser Met Ile Arg Gly Ser Val Pro Asn Gln Met Met Pro 
    690                 695                 700                 


Arg Ile Thr Pro Gln Ser Gly Leu Asn Gln Phe Gly Gln Met Ser Met 
705                 710                 715                 720 


Ala Gln Pro Pro Ile Val Pro Arg Gln Thr Pro Pro Leu Gln His His 
                725                 730                 735     


Gly Gln Leu Ala Gln Pro Gly Ala Leu Asn Pro Pro Met Gly Tyr Gly 
            740                 745                 750         


Pro Arg Met Gln Gln Pro Ser Asn Gln Gly Gln Phe Leu Pro Gln Thr 
        755                 760                 765             


Gln Phe Pro Ser Gln Gly Met Asn Val Thr Asn Ile Pro Leu Ala Pro 
    770                 775                 780                 


Ser Ser Gly Gln Ala Pro Val Ser Gln Ala Gln Met Ser Ser Ser Ser 
785                 790                 795                 800 


Cys Pro Val Asn Ser Pro Ile Met Pro Pro Gly Ser Gln Gly Ser His 
                805                 810                 815     


Ile His Cys Pro Gln Leu Pro Gln Pro Ala Leu His Gln Asn Ser Pro 
            820                 825                 830         


Ser Pro Val Pro Ser Arg Thr Pro Thr Pro His His Thr Pro Pro Ser 
        835                 840                 845             


Ile Gly Ala Gln Gln Pro Pro Ala Thr Thr Ile Pro Ala Pro Val Pro 
    850                 855                 860                 


Thr Pro Pro Ala Met Pro Pro Gly Pro Gln Ser Gln Ala Leu His Pro 
865                 870                 875                 880 


Pro Pro Arg Gln Thr Pro Thr Pro Pro Thr Thr Gln Leu Pro Gln Gln 
                885                 890                 895     


Val Gln Pro Ser Leu Pro Ala Ala Pro Ser Ala Asp Gln Pro Gln Gln 
            900                 905                 910         


Gln Pro Arg Ser Gln Gln Ser Thr Ala Ala Ser Val Pro Thr Pro Thr 
        915                 920                 925             


Ala Pro Leu Leu Pro Pro Gln Pro Ala Thr Pro Leu Ser Gln Pro Ala 
    930                 935                 940                 


Val Ser Ile Glu Gly Gln Val Ser Asn Pro Pro Ser Thr Ser Ser Thr 
945                 950                 955                 960 


Glu Val Asn Ser Gln Ala Ile Ala Glu Lys Gln Pro Ser Gln Glu Val 
                965                 970                 975     


Lys Met Glu Ala Lys Met Glu Val Asp Gln Pro Glu Pro Ala Asp Thr 
            980                 985                 990         


Gln Pro Glu Asp Ile Ser Glu Ser  Lys Val Glu Asp Cys  Lys Met Glu 
        995                 1000                 1005             


Ser Thr  Glu Thr Glu Glu Arg  Ser Thr Glu Leu Lys  Thr Glu Ile 
    1010                 1015                 1020             


Lys Glu  Glu Glu Asp Gln Pro  Ser Thr Ser Ala Thr  Gln Ser Ser 
    1025                 1030                 1035             


Pro Ala  Pro Gly Gln Ser Lys  Lys Lys Ile Phe Lys  Pro Glu Glu 
    1040                 1045                 1050             


Leu Arg  Gln Ala Leu Met Pro  Thr Leu Glu Ala Leu  Tyr Arg Gln 
    1055                 1060                 1065             


Asp Pro  Glu Ser Leu Pro Phe  Arg Gln Pro Val Asp  Pro Gln Leu 
    1070                 1075                 1080             


Leu Gly  Ile Pro Asp Tyr Phe  Asp Ile Val Lys Ser  Pro Met Asp 
    1085                 1090                 1095             


Leu Ser  Thr Ile Lys Arg Lys  Leu Asp Thr Gly Gln  Tyr Gln Glu 
    1100                 1105                 1110             


Pro Trp  Gln Tyr Val Asp Asp  Ile Trp Leu Met Phe  Asn Asn Ala 
    1115                 1120                 1125             


Trp Leu  Tyr Asn Arg Lys Thr  Ser Arg Val Tyr Lys  Tyr Cys Ser 
    1130                 1135                 1140             


Lys Leu  Ser Glu Val Phe Glu  Gln Glu Ile Asp Pro  Val Met Gln 
    1145                 1150                 1155             


Ser Leu  Gly Tyr Cys Cys Gly  Arg Lys Leu Glu Phe  Ser Pro Gln 
    1160                 1165                 1170             


Thr Leu  Cys Cys Tyr Gly Lys  Gln Leu Cys Thr Ile  Pro Arg Asp 
    1175                 1180                 1185             


Ala Thr  Tyr Tyr Ser Tyr Gln  Asn Arg Tyr His Phe  Cys Glu Lys 
    1190                 1195                 1200             


Cys Phe  Asn Glu Ile Gln Gly  Glu Ser Val Ser Leu  Gly Asp Asp 
    1205                 1210                 1215             


Pro Ser  Gln Pro Gln Thr Thr  Ile Asn Lys Glu Gln  Phe Ser Lys 
    1220                 1225                 1230             


Arg Lys  Asn Asp Thr Leu Asp  Pro Glu Leu Phe Val  Glu Cys Thr 
    1235                 1240                 1245             


Glu Cys  Gly Arg Lys Met His  Gln Ile Cys Val Leu  His His Glu 
    1250                 1255                 1260             


Ile Ile  Trp Pro Ala Gly Phe  Val Cys Asp Gly Cys  Leu Lys Lys 
    1265                 1270                 1275             


Ser Ala  Arg Thr Arg Lys Glu  Asn Lys Phe Ser Ala  Lys Arg Leu 
    1280                 1285                 1290             


Pro Ser  Thr Arg Leu Gly Thr  Phe Leu Glu Asn Arg  Val Asn Asp 
    1295                 1300                 1305             


Phe Leu  Arg Arg Gln Asn His  Pro Glu Ser Gly Glu  Val Thr Val 
    1310                 1315                 1320             


Arg Val  Val His Ala Ser Asp  Lys Thr Val Glu Val  Lys Pro Gly 
    1325                 1330                 1335             


Met Lys  Ala Arg Phe Val Asp  Ser Gly Glu Met Ala  Glu Ser Phe 
    1340                 1345                 1350             


Pro Tyr  Arg Thr Lys Ala Leu  Phe Ala Phe Glu Glu  Ile Asp Gly 
    1355                 1360                 1365             


Val Asp  Leu Cys Phe Phe Gly  Met His Val Gln Glu  Tyr Gly Ser 
    1370                 1375                 1380             


Asp Cys  Pro Pro Pro Asn Gln  Arg Arg Val Tyr Ile  Ser Tyr Leu 
    1385                 1390                 1395             


Asp Ser  Val His Phe Phe Arg  Pro Lys Cys Leu Arg  Thr Ala Val 
    1400                 1405                 1410             


Tyr His  Glu Ile Leu Ile Gly  Tyr Leu Glu Tyr Val  Lys Lys Leu 
    1415                 1420                 1425             


Gly Tyr  Thr Thr Gly His Ile  Trp Ala Cys Pro Pro  Ser Glu Gly 
    1430                 1435                 1440             


Asp Asp  Tyr Ile Phe His Cys  His Pro Pro Asp Gln  Lys Ile Pro 
    1445                 1450                 1455             


Lys Pro  Lys Arg Leu Gln Glu  Trp Tyr Lys Lys Met  Leu Asp Lys 
    1460                 1465                 1470             


Ala Val  Ser Glu Arg Ile Val  His Asp Tyr Lys Asp  Ile Phe Lys 
    1475                 1480                 1485             


Gln Ala  Thr Glu Asp Arg Leu  Thr Ser Ala Lys Glu  Leu Pro Tyr 
    1490                 1495                 1500             


Phe Glu  Gly Asp Phe Trp Pro  Asn Val Leu Glu Glu  Ser Ile Lys 
    1505                 1510                 1515             


Glu Leu  Glu Gln Glu Glu Glu  Glu Arg Lys Arg Glu  Glu Asn Thr 
    1520                 1525                 1530             


Ser Asn  Glu Ser Thr Asp Val  Thr Lys Gly Asp Ser  Lys Asn Ala 
    1535                 1540                 1545             


Lys Lys  Lys Asn Asn Lys Lys  Thr Ser Lys Asn Lys  Ser Ser Leu 
    1550                 1555                 1560             


Ser Arg  Gly Asn Lys Lys Lys  Pro Gly Met Pro Asn  Val Ser Asn 
    1565                 1570                 1575             


Asp Leu  Ser Gln Lys Leu Tyr  Ala Thr Met Glu Lys  His Lys Glu 
    1580                 1585                 1590             


Val Phe  Phe Val Ile Arg Leu  Ile Ala Gly Pro Ala  Ala Asn Ser 
    1595                 1600                 1605             


Leu Pro  Pro Ile Val Asp Pro  Asp Pro Leu Ile Pro  Cys Asp Leu 
    1610                 1615                 1620             


Met Asp  Gly Arg Asp Ala Phe  Leu Thr Leu Ala Arg  Asp Lys His 
    1625                 1630                 1635             


Leu Glu  Phe Ser Ser Leu Arg  Arg Ala Gln Trp Ser  Thr Met Cys 
    1640                 1645                 1650             


Met Leu  Val Glu Leu His Thr  Gln Ser Gln Asp Arg  Phe Val Tyr 
    1655                 1660                 1665             


Thr Cys  Asn Glu Cys Lys His  His Val Glu Thr Arg  Trp His Cys 
    1670                 1675                 1680             


Thr Val  Cys Glu Asp Tyr Asp  Leu Cys Ile Thr Cys  Tyr Asn Thr 
    1685                 1690                 1695             


Lys Asn  His Asp His Lys Met  Glu Lys Leu Gly Leu  Gly Leu Asp 
    1700                 1705                 1710             


Asp Glu  Ser Asn Asn Gln Gln  Ala Ala Ala Thr Gln  Ser Pro Gly 
    1715                 1720                 1725             


Asp Ser  Arg Arg Leu Ser Ile  Gln Arg Cys Ile Gln  Ser Leu Val 
    1730                 1735                 1740             


His Ala  Cys Gln Cys Arg Asn  Ala Asn Cys Ser Leu  Pro Ser Cys 
    1745                 1750                 1755             


Gln Lys  Met Lys Arg Val Val  Gln His Thr Lys Gly  Cys Lys Arg 
    1760                 1765                 1770             


Lys Thr  Asn Gly Gly Cys Pro  Ile Cys Lys Gln Leu  Ile Ala Leu 
    1775                 1780                 1785             


Cys Cys  Tyr His Ala Lys His  Cys Gln Glu Asn Lys  Cys Pro Val 
    1790                 1795                 1800             


Pro Phe  Cys Leu Asn Ile Lys  Gln Lys Leu Arg Gln  Gln Gln Leu 
    1805                 1810                 1815             


Gln His  Arg Leu Gln Gln Ala  Gln Met Leu Arg Arg  Arg Met Ala 
    1820                 1825                 1830             


Ser Met  Gln Arg Thr Gly Val  Val Gly Gln Gln Gln  Gly Leu Pro 
    1835                 1840                 1845             


Ser Pro  Thr Pro Ala Thr Pro  Thr Thr Pro Thr Gly  Gln Gln Pro 
    1850                 1855                 1860             


Thr Thr  Pro Gln Thr Pro Gln  Pro Thr Ser Gln Pro  Gln Pro Thr 
    1865                 1870                 1875             


Pro Pro  Asn Ser Met Pro Pro  Tyr Leu Pro Arg Thr  Gln Ala Ala 
    1880                 1885                 1890             


Gly Pro  Val Ser Gln Gly Lys  Ala Ala Gly Gln Val  Thr Pro Pro 
    1895                 1900                 1905             


Thr Pro  Pro Gln Thr Ala Gln  Pro Pro Leu Pro Gly  Pro Pro Pro 
    1910                 1915                 1920             


Ala Ala  Val Glu Met Ala Met  Gln Ile Gln Arg Ala  Ala Glu Thr 
    1925                 1930                 1935             


Gln Arg  Gln Met Ala His Val  Gln Ile Phe Gln Arg  Pro Ile Gln 
    1940                 1945                 1950             


His Gln  Met Pro Pro Met Thr  Pro Met Ala Pro Met  Gly Met Asn 
    1955                 1960                 1965             


Pro Pro  Pro Met Thr Arg Gly  Pro Ser Gly His Leu  Glu Pro Gly 
    1970                 1975                 1980             


Met Gly  Pro Thr Gly Met Gln  Gln Gln Pro Pro Trp  Ser Gln Gly 
    1985                 1990                 1995             


Gly Leu  Pro Gln Pro Gln Gln  Leu Gln Ser Gly Met  Pro Arg Pro 
    2000                 2005                 2010             


Ala Met  Met Ser Val Ala Gln  His Gly Gln Pro Leu  Asn Met Ala 
    2015                 2020                 2025             


Pro Gln  Pro Gly Leu Gly Gln  Val Gly Ile Ser Pro  Leu Lys Pro 
    2030                 2035                 2040             


Gly Thr  Val Ser Gln Gln Ala  Leu Gln Asn Leu Leu  Arg Thr Leu 
    2045                 2050                 2055             


Arg Ser  Pro Ser Ser Pro Leu  Gln Gln Gln Gln Val  Leu Ser Ile 
    2060                 2065                 2070             


Leu His  Ala Asn Pro Gln Leu  Leu Ala Ala Phe Ile  Lys Gln Arg 
    2075                 2080                 2085             


Ala Ala  Lys Tyr Ala Asn Ser  Asn Pro Gln Pro Ile  Pro Gly Gln 
    2090                 2095                 2100             


Pro Gly  Met Pro Gln Gly Gln  Pro Gly Leu Gln Pro  Pro Thr Met 
    2105                 2110                 2115             


Pro Gly  Gln Gln Gly Val His  Ser Asn Pro Ala Met  Gln Asn Met 
    2120                 2125                 2130             


Asn Pro  Met Gln Ala Gly Val  Gln Arg Ala Gly Leu  Pro Gln Gln 
    2135                 2140                 2145             


Gln Pro  Gln Gln Gln Leu Gln  Pro Pro Met Gly Gly  Met Ser Pro 
    2150                 2155                 2160             


Gln Ala  Gln Gln Met Asn Met  Asn His Asn Thr Met  Pro Ser Gln 
    2165                 2170                 2175             


Phe Arg  Asp Ile Leu Arg Arg  Gln Gln Met Met Gln  Gln Gln Gln 
    2180                 2185                 2190             


Gln Gln  Gly Ala Gly Pro Gly  Ile Gly Pro Gly Met  Ala Asn His 
    2195                 2200                 2205             


Asn Gln  Phe Gln Gln Pro Gln  Gly Val Gly Tyr Pro  Pro Gln Gln 
    2210                 2215                 2220             


Gln Gln  Arg Met Gln His His  Met Gln Gln Met Gln  Gln Gly Asn 
    2225                 2230                 2235             


Met Gly  Gln Ile Gly Gln Leu  Pro Gln Ala Leu Gly  Ala Glu Ala 
    2240                 2245                 2250             


Gly Ala  Ser Leu Gln Ala Tyr  Gln Gln Arg Leu Leu  Gln Gln Gln 
    2255                 2260                 2265             


Met Gly  Ser Pro Val Gln Pro  Asn Pro Met Ser Pro  Gln Gln His 
    2270                 2275                 2280             


Met Leu  Pro Asn Gln Ala Gln  Ser Pro His Leu Gln  Gly Gln Gln 
    2285                 2290                 2295             


Ile Pro  Asn Ser Leu Ser Asn  Gln Val Arg Ser Pro  Gln Pro Val 
    2300                 2305                 2310             


Pro Ser  Pro Arg Pro Gln Ser  Gln Pro Pro His Ser  Ser Pro Ser 
    2315                 2320                 2325             


Pro Arg  Met Gln Pro Gln Pro  Ser Pro His His Val  Ser Pro Gln 
    2330                 2335                 2340             


Thr Ser  Ser Pro His Pro Gly  Leu Val Ala Ala Gln  Ala Asn Pro 
    2345                 2350                 2355             


Met Glu  Gln Gly His Phe Ala  Ser Pro Asp Gln Asn  Ser Met Leu 
    2360                 2365                 2370             


Ser Gln  Leu Ala Ser Asn Pro  Gly Met Ala Asn Leu  His Gly Ala 
    2375                 2380                 2385             


Ser Ala  Thr Asp Leu Gly Leu  Ser Thr Asp Asn Ser  Asp Leu Asn 
    2390                 2395                 2400             


Ser Asn  Leu Ser Gln Ser Thr  Leu Asp Ile His 
    2405                 2410                 


<210>  20
<211>  396
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Gly Phe Leu Ser Ala Arg Gln Thr Gly Leu Glu Asp Pro Leu 
1               5                   10                  15      


Arg Leu Arg Arg Ala Glu Ser Thr Arg Arg Val Leu Gly Leu Glu Leu 
            20                  25                  30          


Asn Lys Asp Arg Asp Val Glu Arg Ile His Gly Gly Gly Ile Asn Thr 
        35                  40                  45              


Leu Asp Ile Glu Pro Val Glu Gly Arg Tyr Met Leu Ser Gly Gly Ser 
    50                  55                  60                  


Asp Gly Val Ile Val Leu Tyr Asp Leu Glu Asn Ser Ser Arg Gln Ser 
65                  70                  75                  80  


Tyr Tyr Thr Cys Lys Ala Val Cys Ser Ile Gly Arg Asp His Pro Asp 
                85                  90                  95      


Val His Arg Tyr Ser Val Glu Thr Val Gln Trp Tyr Pro His Asp Thr 
            100                 105                 110         


Gly Met Phe Thr Ser Ser Ser Phe Asp Lys Thr Leu Lys Val Trp Asp 
        115                 120                 125             


Thr Asn Thr Leu Gln Thr Ala Asp Val Phe Asn Phe Glu Glu Thr Val 
    130                 135                 140                 


Tyr Ser His His Met Ser Pro Val Ser Thr Lys His Cys Leu Val Ala 
145                 150                 155                 160 


Val Gly Thr Arg Gly Pro Lys Val Gln Leu Cys Asp Leu Lys Ser Gly 
                165                 170                 175     


Ser Cys Ser His Ile Leu Gln Gly His Arg Gln Glu Ile Leu Ala Val 
            180                 185                 190         


Ser Trp Ser Pro Arg Tyr Asp Tyr Ile Leu Ala Thr Ala Ser Ala Asp 
        195                 200                 205             


Ser Arg Val Lys Leu Trp Asp Val Arg Arg Ala Ser Gly Cys Leu Ile 
    210                 215                 220                 


Thr Leu Asp Gln His Asn Gly Lys Lys Ser Gln Ala Val Glu Ser Ala 
225                 230                 235                 240 


Asn Thr Ala His Asn Gly Lys Val Asn Gly Leu Cys Phe Thr Ser Asp 
                245                 250                 255     


Gly Leu His Leu Leu Thr Val Gly Thr Asp Asn Arg Met Arg Leu Trp 
            260                 265                 270         


Asn Ser Ser Asn Gly Glu Asn Thr Leu Val Asn Tyr Gly Lys Val Cys 
        275                 280                 285             


Asn Asn Ser Lys Lys Gly Leu Lys Phe Thr Val Ser Cys Gly Cys Ser 
    290                 295                 300                 


Ser Glu Phe Val Phe Val Pro Tyr Gly Ser Thr Ile Ala Val Tyr Thr 
305                 310                 315                 320 


Val Tyr Ser Gly Glu Gln Ile Thr Met Leu Lys Gly His Tyr Lys Thr 
                325                 330                 335     


Val Asp Cys Cys Val Phe Gln Ser Asn Phe Gln Glu Leu Tyr Ser Gly 
            340                 345                 350         


Ser Arg Asp Cys Asn Ile Leu Ala Trp Val Pro Ser Leu Tyr Glu Pro 
        355                 360                 365             


Val Pro Asp Asp Asp Glu Thr Thr Thr Lys Ser Gln Leu Asn Pro Ala 
    370                 375                 380                 


Phe Glu Asp Ala Trp Ser Ser Ser Asp Glu Glu Gly 
385                 390                 395     


<210>  21
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Asp Glu Glu Pro Glu Arg Thr Lys Arg Trp Glu Gly Gly Tyr Glu 
1               5                   10                  15      


Arg Thr Trp Glu Ile Leu Lys Glu Asp Glu Ser Gly Ser Leu Lys Ala 
            20                  25                  30          


Thr Ile Glu Asp Ile Leu Phe Lys Ala Lys Arg Lys Arg Val Phe Glu 
        35                  40                  45              


His His Gly Gln Val Arg Leu Gly Met Met Arg His Leu Tyr Val Val 
    50                  55                  60                  


Val Asp Gly Ser Arg Thr Met Glu Asp Gln Asp Leu Lys Pro Asn Arg 
65                  70                  75                  80  


Leu Thr Cys Thr Leu Lys Leu Leu Glu Tyr Phe Val Glu Glu Tyr Phe 
                85                  90                  95      


Asp Gln Asn Pro Ile Ser Gln Ile Gly Ile Ile Val Thr Lys Ser Lys 
            100                 105                 110         


Arg Ala Glu Lys Leu Thr Glu Leu Ser Gly Asn Pro Arg Lys His Ile 
        115                 120                 125             


Thr Ser Leu Lys Lys Ala Val Asp Met Thr Cys His Gly Glu Pro Ser 
    130                 135                 140                 


Leu Tyr Asn Ser Leu Ser Ile Ala Met Gln Thr Leu Lys His Met Pro 
145                 150                 155                 160 


Gly His Thr Ser Arg Glu Val Leu Ile Ile Phe Ser Ser Leu Thr Thr 
                165                 170                 175     


Cys Asp Pro Ser Asn Ile Tyr Asp Leu Ile Lys Thr Leu Lys Ala Ala 
            180                 185                 190         


Lys Ile Arg Val Ser Val Ile Gly Leu Ser Ala Glu Val Arg Val Cys 
        195                 200                 205             


Thr Val Leu Ala Arg Glu Thr Gly Gly Thr Tyr His Val Ile Leu Asp 
    210                 215                 220                 


Glu Ser His Tyr Lys Glu Leu Leu Thr His His Val Ser Pro Pro Pro 
225                 230                 235                 240 


Ala Ser Ser Ser Ser Glu Cys Ser Leu Ile Arg Met Gly Phe Pro Gln 
                245                 250                 255     


His Thr Ile Ala Ser Leu Ser Asp Gln Asp Ala Lys Pro Ser Phe Ser 
            260                 265                 270         


Met Ala His Leu Asp Gly Asn Thr Glu Pro Gly Leu Thr Leu Gly Gly 
        275                 280                 285             


Tyr Phe Cys Pro Gln Cys Arg Ala Lys Tyr Cys Glu Leu Pro Val Glu 
    290                 295                 300                 


Cys Lys Ile Cys Gly Leu Thr Leu Val Ser Ala Pro His Leu Ala Arg 
305                 310                 315                 320 


Ser Tyr His His Leu Phe Pro Leu Asp Ala Phe Gln Glu Ile Pro Leu 
                325                 330                 335     


Glu Glu Tyr Asn Gly Glu Arg Phe Cys Tyr Gly Cys Gln Gly Glu Leu 
            340                 345                 350         


Lys Asp Gln His Val Tyr Val Cys Ala Val Cys Gln Asn Val Phe Cys 
        355                 360                 365             


Val Asp Cys Asp Val Phe Val His Asp Ser Leu His Cys Cys Pro Gly 
    370                 375                 380                 


Cys Ile His Lys Ile Pro Ala Pro Ser Gly Val 
385                 390                 395 


<210>  22
<211>  363
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Val Thr Ile Thr Leu Lys Thr Leu Gln Gln Gln Thr Phe Lys 
1               5                   10                  15      


Ile Arg Met Glu Pro Asp Glu Thr Val Lys Val Leu Lys Glu Lys Ile 
            20                  25                  30          


Glu Ala Glu Lys Gly Arg Asp Ala Phe Pro Val Ala Gly Gln Lys Leu 
        35                  40                  45              


Ile Tyr Ala Gly Lys Ile Leu Ser Asp Asp Val Pro Ile Arg Asp Tyr 
    50                  55                  60                  


Arg Ile Asp Glu Lys Asn Phe Val Val Val Met Val Thr Lys Thr Lys 
65                  70                  75                  80  


Ala Gly Gln Gly Thr Ser Ala Pro Pro Glu Ala Ser Pro Thr Ala Ala 
                85                  90                  95      


Pro Glu Ser Ser Thr Ser Phe Pro Pro Ala Pro Thr Ser Gly Met Ser 
            100                 105                 110         


His Pro Pro Pro Ala Ala Arg Glu Asp Lys Ser Pro Ser Glu Glu Ser 
        115                 120                 125             


Ala Pro Thr Thr Ser Pro Glu Ser Val Ser Gly Ser Val Pro Ser Ser 
    130                 135                 140                 


Gly Ser Ser Gly Arg Glu Glu Asp Ala Ala Ser Thr Leu Val Thr Gly 
145                 150                 155                 160 


Ser Glu Tyr Glu Thr Met Leu Thr Glu Ile Met Ser Met Gly Tyr Glu 
                165                 170                 175     


Arg Glu Arg Val Val Ala Ala Leu Arg Ala Ser Tyr Asn Asn Pro His 
            180                 185                 190         


Arg Ala Val Glu Tyr Leu Leu Thr Gly Ile Pro Gly Ser Pro Glu Pro 
        195                 200                 205             


Glu His Gly Ser Val Gln Glu Ser Gln Val Ser Glu Gln Pro Ala Thr 
    210                 215                 220                 


Glu Ala Ala Gly Glu Asn Pro Leu Glu Phe Leu Arg Asp Gln Pro Gln 
225                 230                 235                 240 


Phe Gln Asn Met Arg Gln Val Ile Gln Gln Asn Pro Ala Leu Leu Pro 
                245                 250                 255     


Ala Leu Leu Gln Gln Leu Gly Gln Glu Asn Pro Gln Leu Leu Gln Gln 
            260                 265                 270         


Ile Ser Arg His Gln Glu Gln Phe Ile Gln Met Leu Asn Glu Pro Pro 
        275                 280                 285             


Gly Glu Leu Ala Asp Ile Ser Asp Val Glu Gly Glu Val Gly Ala Ile 
    290                 295                 300                 


Gly Glu Glu Ala Pro Gln Met Asn Tyr Ile Gln Val Thr Pro Gln Glu 
305                 310                 315                 320 


Lys Glu Ala Ile Glu Arg Leu Lys Ala Leu Gly Phe Pro Glu Ser Leu 
                325                 330                 335     


Val Ile Gln Ala Tyr Phe Ala Cys Glu Lys Asn Glu Asn Leu Ala Ala 
            340                 345                 350         


Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu 
        355                 360             


<210>  23
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Ala Ala Asp Gly Ala Leu Pro Glu Ala Ala Ala Leu Glu Gln 
1               5                   10                  15      


Pro Ala Glu Leu Pro Ala Ser Val Arg Ala Ser Ile Glu Arg Lys Arg 
            20                  25                  30          


Gln Arg Ala Leu Met Leu Arg Gln Ala Arg Leu Ala Ala Arg Pro Tyr 
        35                  40                  45              


Ser Ala Thr Ala Ala Ala Ala Thr Gly Gly Met Ala Asn Val Lys Ala 
    50                  55                  60                  


Ala Pro Lys Ile Ile Asp Thr Gly Gly Gly Phe Ile Leu Glu Glu Glu 
65                  70                  75                  80  


Glu Glu Glu Glu Gln Lys Ile Gly Lys Val Val His Gln Pro Gly Pro 
                85                  90                  95      


Val Met Glu Phe Asp Tyr Val Ile Cys Glu Glu Cys Gly Lys Glu Phe 
            100                 105                 110         


Met Asp Ser Tyr Leu Met Asn His Phe Asp Leu Pro Thr Cys Asp Asn 
        115                 120                 125             


Cys Arg Asp Ala Asp Asp Lys His Lys Leu Ile Thr Lys Thr Glu Ala 
    130                 135                 140                 


Lys Gln Glu Tyr Leu Leu Lys Asp Cys Asp Leu Glu Lys Arg Glu Pro 
145                 150                 155                 160 


Pro Leu Lys Phe Ile Val Lys Lys Asn Pro His His Ser Gln Trp Gly 
                165                 170                 175     


Asp Met Lys Leu Tyr Leu Lys Leu Gln Ile Val Lys Arg Ser Leu Glu 
            180                 185                 190         


Val Trp Gly Ser Gln Glu Ala Leu Glu Glu Ala Lys Glu Val Arg Gln 
        195                 200                 205             


Glu Asn Arg Glu Lys Met Lys Gln Lys Lys Phe Asp Lys Lys Val Lys 
    210                 215                 220                 


Glu Leu Arg Arg Ala Val Arg Ser Ser Val Trp Lys Arg Glu Thr Ile 
225                 230                 235                 240 


Val His Gln His Glu Tyr Gly Pro Glu Glu Asn Leu Glu Asp Asp Met 
                245                 250                 255     


Tyr Arg Lys Thr Cys Thr Met Cys Gly His Glu Leu Thr Tyr Glu Lys 
            260                 265                 270         


Met 
    


<210>  24
<211>  294
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Asp Ser Met Asp Met Asp Met Ser Pro Leu Arg Pro Gln Asn 
1               5                   10                  15      


Tyr Leu Phe Gly Cys Glu Leu Lys Ala Asp Lys Asp Tyr His Phe Lys 
            20                  25                  30          


Val Asp Asn Asp Glu Asn Glu His Gln Leu Ser Leu Arg Thr Val Ser 
        35                  40                  45              


Leu Gly Ala Gly Ala Lys Asp Glu Leu His Ile Val Glu Ala Glu Ala 
    50                  55                  60                  


Met Asn Tyr Glu Gly Ser Pro Ile Lys Val Thr Leu Ala Thr Leu Lys 
65                  70                  75                  80  


Met Ser Val Gln Pro Thr Val Ser Leu Gly Gly Phe Glu Ile Thr Pro 
                85                  90                  95      


Pro Val Val Leu Arg Leu Lys Cys Gly Ser Gly Pro Val His Ile Ser 
            100                 105                 110         


Gly Gln His Leu Val Ala Val Glu Glu Asp Ala Glu Ser Glu Asp Glu 
        115                 120                 125             


Glu Glu Glu Asp Val Lys Leu Leu Ser Ile Ser Gly Lys Arg Ser Ala 
    130                 135                 140                 


Pro Gly Gly Gly Ser Lys Val Pro Gln Lys Lys Val Lys Leu Ala Ala 
145                 150                 155                 160 


Asp Glu Asp Asp Asp Asp Asp Asp Glu Glu Asp Asp Asp Glu Asp Asp 
                165                 170                 175     


Asp Asp Asp Asp Phe Asp Asp Glu Glu Ala Glu Glu Lys Ala Pro Val 
            180                 185                 190         


Lys Lys Ser Ile Arg Asp Thr Pro Ala Lys Asn Ala Gln Lys Ser Asn 
        195                 200                 205             


Gln Asn Gly Lys Asp Ser Lys Pro Ser Ser Thr Pro Arg Ser Lys Gly 
    210                 215                 220                 


Gln Glu Ser Phe Lys Lys Gln Glu Lys Thr Pro Lys Thr Pro Lys Gly 
225                 230                 235                 240 


Pro Ser Ser Val Glu Asp Ile Lys Ala Lys Met Gln Ala Ser Ile Glu 
                245                 250                 255     


Lys Gly Gly Ser Leu Pro Lys Val Glu Ala Lys Phe Ile Asn Tyr Val 
            260                 265                 270         


Lys Asn Cys Phe Arg Met Thr Asp Gln Glu Ala Ile Gln Asp Leu Trp 
        275                 280                 285             


Gln Trp Arg Lys Ser Leu 
    290                 


<210>  25
<211>  993
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Pro Ala Leu Ala Arg Asp Gly Gly Gln Leu Pro Leu Leu Val Val 
1               5                   10                  15      


Phe Ser Ala Met Ile Phe Gly Thr Ile Thr Asn Gln Asp Leu Pro Val 
            20                  25                  30          


Ile Lys Cys Val Leu Ile Asn His Lys Asn Asn Asp Ser Ser Val Gly 
        35                  40                  45              


Lys Ser Ser Ser Tyr Pro Met Val Ser Glu Ser Pro Glu Asp Leu Gly 
    50                  55                  60                  


Cys Ala Leu Arg Pro Gln Ser Ser Gly Thr Val Tyr Glu Ala Ala Ala 
65                  70                  75                  80  


Val Glu Val Asp Val Ser Ala Ser Ile Thr Leu Gln Val Leu Val Asp 
                85                  90                  95      


Ala Pro Gly Asn Ile Ser Cys Leu Trp Val Phe Lys His Ser Ser Leu 
            100                 105                 110         


Asn Cys Gln Pro His Phe Asp Leu Gln Asn Arg Gly Val Val Ser Met 
        115                 120                 125             


Val Ile Leu Lys Met Thr Glu Thr Gln Ala Gly Glu Tyr Leu Leu Phe 
    130                 135                 140                 


Ile Gln Ser Glu Ala Thr Asn Tyr Thr Ile Leu Phe Thr Val Ser Ile 
145                 150                 155                 160 


Arg Asn Thr Leu Leu Tyr Thr Leu Arg Arg Pro Tyr Phe Arg Lys Met 
                165                 170                 175     


Glu Asn Gln Asp Ala Leu Val Cys Ile Ser Glu Ser Val Pro Glu Pro 
            180                 185                 190         


Ile Val Glu Trp Val Leu Cys Asp Ser Gln Gly Glu Ser Cys Lys Glu 
        195                 200                 205             


Glu Ser Pro Ala Val Val Lys Lys Glu Glu Lys Val Leu His Glu Leu 
    210                 215                 220                 


Phe Gly Thr Asp Ile Arg Cys Cys Ala Arg Asn Glu Leu Gly Arg Glu 
225                 230                 235                 240 


Cys Thr Arg Leu Phe Thr Ile Asp Leu Asn Gln Thr Pro Gln Thr Thr 
                245                 250                 255     


Leu Pro Gln Leu Phe Leu Lys Val Gly Glu Pro Leu Trp Ile Arg Cys 
            260                 265                 270         


Lys Ala Val His Val Asn His Gly Phe Gly Leu Thr Trp Glu Leu Glu 
        275                 280                 285             


Asn Lys Ala Leu Glu Glu Gly Asn Tyr Phe Glu Met Ser Thr Tyr Ser 
    290                 295                 300                 


Thr Asn Arg Thr Met Ile Arg Ile Leu Phe Ala Phe Val Ser Ser Val 
305                 310                 315                 320 


Ala Arg Asn Asp Thr Gly Tyr Tyr Thr Cys Ser Ser Ser Lys His Pro 
                325                 330                 335     


Ser Gln Ser Ala Leu Val Thr Ile Val Glu Lys Gly Phe Ile Asn Ala 
            340                 345                 350         


Thr Asn Ser Ser Glu Asp Tyr Glu Ile Asp Gln Tyr Glu Glu Phe Cys 
        355                 360                 365             


Phe Ser Val Arg Phe Lys Ala Tyr Pro Gln Ile Arg Cys Thr Trp Thr 
    370                 375                 380                 


Phe Ser Arg Lys Ser Phe Pro Cys Glu Gln Lys Gly Leu Asp Asn Gly 
385                 390                 395                 400 


Tyr Ser Ile Ser Lys Phe Cys Asn His Lys His Gln Pro Gly Glu Tyr 
                405                 410                 415     


Ile Phe His Ala Glu Asn Asp Asp Ala Gln Phe Thr Lys Met Phe Thr 
            420                 425                 430         


Leu Asn Ile Arg Arg Lys Pro Gln Val Leu Ala Glu Ala Ser Ala Ser 
        435                 440                 445             


Gln Ala Ser Cys Phe Ser Asp Gly Tyr Pro Leu Pro Ser Trp Thr Trp 
    450                 455                 460                 


Lys Lys Cys Ser Asp Lys Ser Pro Asn Cys Thr Glu Glu Ile Thr Glu 
465                 470                 475                 480 


Gly Val Trp Asn Arg Lys Ala Asn Arg Lys Val Phe Gly Gln Trp Val 
                485                 490                 495     


Ser Ser Ser Thr Leu Asn Met Ser Glu Ala Ile Lys Gly Phe Leu Val 
            500                 505                 510         


Lys Cys Cys Ala Tyr Asn Ser Leu Gly Thr Ser Cys Glu Thr Ile Leu 
        515                 520                 525             


Leu Asn Ser Pro Gly Pro Phe Pro Phe Ile Gln Asp Asn Ile Ser Phe 
    530                 535                 540                 


Tyr Ala Thr Ile Gly Val Cys Leu Leu Phe Ile Val Val Leu Thr Leu 
545                 550                 555                 560 


Leu Ile Cys His Lys Tyr Lys Lys Gln Phe Arg Tyr Glu Ser Gln Leu 
                565                 570                 575     


Gln Met Val Gln Val Thr Gly Ser Ser Asp Asn Glu Tyr Phe Tyr Val 
            580                 585                 590         


Asp Phe Arg Glu Tyr Glu Tyr Asp Leu Lys Trp Glu Phe Pro Arg Glu 
        595                 600                 605             


Asn Leu Glu Phe Gly Lys Val Leu Gly Ser Gly Ala Phe Gly Lys Val 
    610                 615                 620                 


Met Asn Ala Thr Ala Tyr Gly Ile Ser Lys Thr Gly Val Ser Ile Gln 
625                 630                 635                 640 


Val Ala Val Lys Met Leu Lys Glu Lys Ala Asp Ser Ser Glu Arg Glu 
                645                 650                 655     


Ala Leu Met Ser Glu Leu Lys Met Met Thr Gln Leu Gly Ser His Glu 
            660                 665                 670         


Asn Ile Val Asn Leu Leu Gly Ala Cys Thr Leu Ser Gly Pro Ile Tyr 
        675                 680                 685             


Leu Ile Phe Glu Tyr Cys Cys Tyr Gly Asp Leu Leu Asn Tyr Leu Arg 
    690                 695                 700                 


Ser Lys Arg Glu Lys Phe His Arg Thr Trp Thr Glu Ile Phe Lys Glu 
705                 710                 715                 720 


His Asn Phe Ser Phe Tyr Pro Thr Phe Gln Ser His Pro Asn Ser Ser 
                725                 730                 735     


Met Pro Gly Ser Arg Glu Val Gln Ile His Pro Asp Ser Asp Gln Ile 
            740                 745                 750         


Ser Gly Leu His Gly Asn Ser Phe His Ser Glu Asp Glu Ile Glu Tyr 
        755                 760                 765             


Glu Asn Gln Lys Arg Leu Glu Glu Glu Glu Asp Leu Asn Val Leu Thr 
    770                 775                 780                 


Phe Glu Asp Leu Leu Cys Phe Ala Tyr Gln Val Ala Lys Gly Met Glu 
785                 790                 795                 800 


Phe Leu Glu Phe Lys Ser Cys Val His Arg Asp Leu Ala Ala Arg Asn 
                805                 810                 815     


Val Leu Val Thr His Gly Lys Val Val Lys Ile Cys Asp Phe Gly Leu 
            820                 825                 830         


Ala Arg Asp Ile Met Ser Asp Ser Asn Tyr Val Val Arg Gly Asn Ala 
        835                 840                 845             


Arg Leu Pro Val Lys Trp Met Ala Pro Glu Ser Leu Phe Glu Gly Ile 
    850                 855                 860                 


Tyr Thr Ile Lys Ser Asp Val Trp Ser Tyr Gly Ile Leu Leu Trp Glu 
865                 870                 875                 880 


Ile Phe Ser Leu Gly Val Asn Pro Tyr Pro Gly Ile Pro Val Asp Ala 
                885                 890                 895     


Asn Phe Tyr Lys Leu Ile Gln Asn Gly Phe Lys Met Asp Gln Pro Phe 
            900                 905                 910         


Tyr Ala Thr Glu Glu Ile Tyr Ile Ile Met Gln Ser Cys Trp Ala Phe 
        915                 920                 925             


Asp Ser Arg Lys Arg Pro Ser Phe Pro Asn Leu Thr Ser Phe Leu Gly 
    930                 935                 940                 


Cys Gln Leu Ala Asp Ala Glu Glu Ala Met Tyr Gln Asn Val Asp Gly 
945                 950                 955                 960 


Arg Val Ser Glu Cys Pro His Thr Tyr Gln Asn Arg Arg Pro Phe Ser 
                965                 970                 975     


Arg Glu Met Asp Leu Gly Leu Leu Ser Pro Gln Ala Gln Val Glu Asp 
            980                 985                 990         


Ser 
    


