                         SEQUENCE LISTING

<110>  HUTCHISON MEDIPHARMA LIMITED
 
<120>  ANTI-OX40 ANTIBODY AND USES THEREOF

<130>  PF210196PCT

<160>  22    

<170>  PatentIn version 3.3

<210>  1
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  1

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ser 
1               5                   10                  15      


Ser Val Gln Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asp Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Gln Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  2
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  4
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  5
<211>  120
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  5

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Val Asp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Val Thr Leu Thr Val Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  6
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  6

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Ala Thr Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ser Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  8

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ser Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  9
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  9

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ser Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  10
<211>  111
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  10

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Glu Ser Val Asp Ser Ser 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Arg Ala Ser Asn Leu Glu Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Val Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Ser Asn 
                85                  90                  95      


Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  11
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  11

Ser Tyr Trp Val Asp 
1               5   


<210>  12
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  12

Asn Ile Tyr Pro Ser Asp Ser Glu Thr His Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  13
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  13

Ser Tyr Gly Tyr Tyr Gly Thr Trp Phe Ala Tyr 
1               5                   10      


<210>  14
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  14

Arg Ala Ser Glu Ser Val Asp Ser Ser Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  15
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  15

Arg Ala Ser Asn Leu Glu Ser 
1               5           


<210>  16
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  16

Gln Gln Ser Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  17
<211>  360
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  17

Cys Ala Gly Gly Thr Cys Cys Ala Ala Cys Thr Gly Cys Ala Gly Cys 
1               5                   10                  15      


Ala Gly Cys Cys Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Ala Gly Gly Cys Cys Thr Gly Gly Gly Thr Cys Thr 
        35                  40                  45              


Thr Cys Ala Gly Thr Gly Cys Ala Gly Thr Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Thr Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Cys Cys Ala Gly Cys Thr Ala Cys 
                85                  90                  95      


Thr Gly Gly Gly Thr Gly Gly Ala Thr Thr Gly Gly Gly Thr Gly Ala 
            100                 105                 110         


Ala Gly Cys Ala Gly Ala Gly Gly Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Cys Cys Thr Thr Cys Ala Ala Thr Gly Gly Ala Thr Thr 
    130                 135                 140                 


Gly Gly Thr Ala Ala Cys Ala Thr Thr Thr Ala Cys Cys Cys Thr Thr 
145                 150                 155                 160 


Cys Thr Gly Ala Thr Ala Gly Thr Gly Ala Ala Ala Cys Thr Cys Ala 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Thr Cys Ala Ala Ala Ala Gly Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Cys Ala Ala Gly Gly Cys Cys Ala Cys Ala Thr 
        195                 200                 205             


Thr Gly Ala Cys Thr Gly Thr Ala Gly Ala Cys Ala Ala Ala Thr Cys 
    210                 215                 220                 


Cys Thr Cys Cys Ala Gly Cys Ala Cys Ala Gly Cys Cys Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Cys Ala Gly Cys Thr Cys Ala Gly Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Cys Ala Thr Cys Thr Gly Ala Ala Gly Ala Cys Thr Cys 
            260                 265                 270         


Thr Gly Cys Gly Gly Thr Cys Thr Ala Thr Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Ala Ala Gly Ala Thr Cys Thr Thr Ala Thr Gly Gly Thr Thr 
    290                 295                 300                 


Ala Cys Thr Ala Cys Gly Gly Gly Ala Cys Cys Thr Gly Gly Thr Thr 
305                 310                 315                 320 


Thr Gly Cys Thr Thr Ala Cys Thr Gly Gly Gly Gly Cys Cys Ala Ala 
                325                 330                 335     


Gly Gly Gly Ala Cys Thr Cys Thr Gly Gly Thr Cys Ala Cys Thr Gly 
            340                 345                 350         


Thr Cys Thr Cys Thr Gly Cys Ala 
        355                 360 


<210>  18
<211>  360
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  18

Cys Ala Gly Gly Thr Thr Cys Ala Gly Thr Thr Gly Gly Thr Thr Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Cys Gly Cys Cys Gly Ala Ala Gly Thr 
            20                  25                  30          


Gly Ala Ala Gly Ala Ala Ala Cys Cys Thr Gly Gly Cys Gly Cys Cys 
        35                  40                  45              


Thr Cys Thr Gly Thr Gly Ala Ala Gly Gly Thr Gly Thr Cys Cys Thr 
    50                  55                  60                  


Gly Cys Ala Ala Gly Gly Cys Thr Thr Cys Cys Gly Gly Cys Thr Ala 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Thr Ala Cys Cys Ala Gly Cys Thr Ala Cys 
                85                  90                  95      


Thr Gly Gly Gly Thr Cys Gly Ala Cys Thr Gly Gly Gly Thr Cys Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Thr Cys Cys Thr Gly Gly Ala Cys Ala 
        115                 120                 125             


Ala Gly Gly Ala Cys Thr Gly Gly Ala Ala Thr Gly Gly Ala Thr Gly 
    130                 135                 140                 


Gly Gly Cys Ala Ala Cys Ala Thr Cys Thr Ala Cys Cys Cys Cys Thr 
145                 150                 155                 160 


Cys Cys Gly Ala Cys Thr Cys Cys Gly Ala Gly Ala Cys Ala Cys Ala 
                165                 170                 175     


Cys Thr Ala Cys Ala Ala Cys Cys Ala Gly Ala Ala Ala Thr Thr Cys 
            180                 185                 190         


Ala Ala Gly Gly Ala Cys Cys Gly Cys Gly Thr Gly Ala Cys Cys Ala 
        195                 200                 205             


Thr Gly Ala Cys Cys Ala Gly Ala Gly Ala Cys Ala Cys Cys Thr Cys 
    210                 215                 220                 


Cys Ala Cys Cys Ala Gly Cys Ala Cys Cys Gly Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Ala Thr Gly Gly Ala Ala Cys Thr Gly Thr Cys Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Thr Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Cys 
        275                 280                 285             


Gly Cys Cys Ala Gly Ala Thr Cys Cys Thr Ala Cys Gly Gly Cys Thr 
    290                 295                 300                 


Ala Cys Thr Ala Cys Gly Gly Cys Ala Cys Thr Thr Gly Gly Thr Thr 
305                 310                 315                 320 


Thr Gly Cys Cys Thr Ala Thr Thr Gly Gly Gly Gly Cys Cys Ala Gly 
                325                 330                 335     


Gly Gly Cys Ala Cys Ala Cys Thr Gly Gly Thr Cys Ala Cys Cys Gly 
            340                 345                 350         


Thr Thr Thr Cys Thr Thr Cys Cys 
        355                 360 


<210>  19
<211>  333
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  19

Gly Ala Cys Ala Thr Thr Gly Thr Gly Cys Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Ala Thr Cys Thr Cys Cys Ala Gly Cys Thr Thr Cys Thr Thr Thr 
            20                  25                  30          


Gly Gly Cys Thr Gly Thr Gly Thr Cys Thr Cys Thr Ala Gly Gly Gly 
        35                  40                  45              


Cys Ala Gly Ala Gly Gly Gly Cys Cys Ala Cys Cys Ala Thr Ala Thr 
    50                  55                  60                  


Cys Cys Thr Gly Cys Ala Gly Ala Gly Cys Cys Ala Gly Thr Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Thr Gly Thr Thr Gly Ala Thr Ala Gly Thr Thr Cys Thr 
                85                  90                  95      


Gly Gly Cys Ala Ala Thr Ala Gly Thr Thr Thr Thr Ala Thr Gly Cys 
            100                 105                 110         


Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Gly Cys Ala Gly Ala Ala 
        115                 120                 125             


Ala Cys Cys Ala Gly Gly Ala Cys Ala Gly Cys Cys Ala Cys Cys Cys 
    130                 135                 140                 


Ala Ala Ala Cys Thr Cys Cys Thr Cys Ala Thr Cys Thr Ala Thr Cys 
145                 150                 155                 160 


Gly Thr Gly Cys Ala Thr Cys Cys Ala Ala Cys Cys Thr Ala Gly Ala 
                165                 170                 175     


Ala Thr Cys Thr Gly Gly Gly Ala Thr Cys Cys Cys Thr Gly Cys Cys 
            180                 185                 190         


Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Ala Gly Thr Gly 
        195                 200                 205             


Gly Gly Thr Cys Thr Ala Gly Gly Ala Cys Ala Gly Ala Cys Thr Thr 
    210                 215                 220                 


Cys Ala Cys Cys Cys Thr Cys Ala Cys Cys Ala Thr Thr Ala Ala Thr 
225                 230                 235                 240 


Cys Cys Thr Gly Thr Gly Gly Ala Gly Gly Cys Thr Gly Ala Thr Gly 
                245                 250                 255     


Ala Thr Gly Thr Thr Gly Cys Ala Ala Cys Cys Thr Ala Thr Thr Ala 
            260                 265                 270         


Cys Thr Gly Thr Cys Ala Gly Cys Ala Ala Ala Gly Thr Ala Ala Thr 
        275                 280                 285             


Gly Ala Gly Gly Ala Thr Cys Cys Gly Thr Gly Gly Ala Cys Gly Thr 
    290                 295                 300                 


Thr Cys Gly Gly Thr Gly Gly Ala Gly Gly Cys Ala Cys Cys Ala Ala 
305                 310                 315                 320 


Ala Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Ala 
                325                 330             


<210>  20
<211>  333
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  20

Gly Ala Thr Ala Thr Cys Gly Thr Gly Ala Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Thr Cys Thr Cys Cys Thr Gly Ala Cys Ala Gly Cys Cys Thr 
            20                  25                  30          


Gly Gly Cys Thr Gly Thr Gly Thr Cys Thr Cys Thr Gly Gly Gly Cys 
        35                  40                  45              


Gly Ala Gly Ala Gly Ala Gly Cys Cys Ala Cys Cys Ala Thr Cys Ala 
    50                  55                  60                  


Ala Cys Thr Gly Cys Ala Gly Ala Gly Cys Cys Thr Cys Thr Gly Ala 
65                  70                  75                  80  


Gly Thr Cys Cys Gly Thr Gly Gly Ala Cys Thr Cys Cys Thr Cys Cys 
                85                  90                  95      


Gly Gly Cys Ala Ala Cys Thr Cys Thr Thr Thr Cys Ala Thr Gly Cys 
            100                 105                 110         


Ala Cys Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala Ala 
        115                 120                 125             


Gly Cys Cys Cys Gly Gly Cys Cys Ala Gly Cys Cys Thr Cys Cys Thr 
    130                 135                 140                 


Ala Ala Gly Cys Thr Gly Cys Thr Gly Ala Thr Cys Thr Ala Cys Ala 
145                 150                 155                 160 


Gly Ala Gly Cys Cys Thr Cys Cys Ala Ala Cys Cys Thr Gly Gly Ala 
                165                 170                 175     


Ala Thr Cys Thr Gly Gly Cys Gly Thr Gly Cys Cys Cys Gly Ala Cys 
            180                 185                 190         


Ala Gly Ala Thr Thr Cys Thr Cys Cys Gly Gly Cys Thr Cys Thr Gly 
        195                 200                 205             


Gly Cys Thr Cys Thr Gly Gly Cys Ala Cys Ala Gly Ala Cys Thr Thr 
    210                 215                 220                 


Thr Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Cys Ala Gly Cys 
225                 230                 235                 240 


Thr Cys Cys Cys Thr Gly Cys Ala Gly Gly Cys Cys Gly Ala Gly Gly 
                245                 250                 255     


Ala Thr Gly Thr Gly Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala 
            260                 265                 270         


Cys Thr Gly Cys Cys Ala Gly Cys Ala Gly Thr Cys Cys Ala Ala Cys 
        275                 280                 285             


Gly Ala Gly Gly Ala Cys Cys Cys Cys Thr Gly Gly Ala Cys Ala Thr 
    290                 295                 300                 


Thr Thr Gly Gly Cys Gly Gly Cys Gly Gly Ala Ala Cys Ala Ala Ala 
305                 310                 315                 320 


Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala Ala Gly 
                325                 330             


<210>  21
<211>  330
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  21

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  22
<211>  326
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  22

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


